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California Stem Cell Report: Former CEO of California Stem …

Posted: September 27, 2014 at 8:53 am

Alan Trounson, the former president of the $3 billion California stem cell agency, today was named to the board of a company that hasreceived $19.4 million from the agency, raising fresh and serious questions about conflicts of interest at the state-funded research program. Announcement of the appointment came only seven days after Trounson left state employment. Trounson has been dogged for some time with questions about his relationship to the company, StemCells, Inc., of Newark, Ca., and its co-founder, eminent Stanford researcher Irv Weissman, who sits on the companys six-man board and is chairman of its scientific advisory board. StemCells, Inc., announced Trounsons appointment in a press release this morning. The publicly traded firm said it was thrilled to have Trounson on its board. The first sentence of its press release noted that he had served as head of the largest scientific funding body for stem cell research in the world. Weissman is director of the Institute of Stem Cell Biology and Regenerative Medicine at Stanford. He has received $34.7 million from the agency. Stanford overall has received $281 million from the stem cell agency, formally known as the California Institute for Regenerative Medicine (CIRM). It is the No. 1 recipient of cash from the agency.

One California stem cell researcher, who asked to remain anonymous, said in an email,

StemCells, Inc., Weissman and the stem cell agency did not immediately respond to requests for comment. Trounson, who announced last fall he was leaving the agency to return to Australia, could not be reached. The California Stem Cell Report will carry the full text of their remarks when they are received.

As the California Stem Cell Report has previously noted,,

Under CIRM's procedures, Trounson does not vote on applications during the review process. But beginning last year the board gave him and his staff new authority to make recommendations on applications after they were acted on by reviewers.

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Stem Cell Treatments – What options do I have?

Posted: September 27, 2014 at 8:53 am

Most everyone has heard about the controversy surrounding stem cell research and treatment. It seems like just about every media outletmagazines, newspapers, televisionhas played host to the debate regarding whether stem cell research and treatment are moral and/or ethical.

Because stem cells have the potential to generate cells designed to replace or repair cells damaged by spinal cord injury, advocates of stem cell research and treatment believe that the benefits far outweigh the negative aspects. Opponents of this research and treatment, however, typically bring up the issue of embryonic stem cells, which are harvested from embryos and fetal tissue. Accordingly, they feel the use of these embryonic stem cells is not moral or ethical. Because stem cells are harvested from embryos and fetal tissue, they feel it is not moral or ethical. Secondly, opponents are concerned about the health and safety of the participants in human stem cell research trials. It is important to note that non-embryonic stem cells, called somatic or adult stem cells, have recently been identified in various body tissues including brain, bone marrow, blood vessels, and various organ tissues.

Lets talk about how stem cell research could possibly impact spinal cord injury. Stem cell research came on the scene in 1998, when a group of scientists isolated pluripotent stem cells from human embryos and grew them in a culture. Since then, specialists have discovered that stem cells can become any of the 200 specialized cells in the body, giving them the ability to repair or replace damaged cells and tissues. While not yet known to have the diversification potential of embryonic stem cells, adult somatic cells act similarly and are generating excitement in the research and medical community.

When all is said and done, could stem cell treatment be the miracle cure for spinal cord injury and paralysis? Well, we dont really know. Because of all of the controversy, much of the evidence that shows stem cells can be turned into specific cells for transplantation involves only mice, whose cells are significantly different than human cells. Nevertheless, some initial research points to promising results. One hurdle that remains to be cleared is whether an immune response would reject a cellular transplant.

Ultimately, no one yet knows the extent to which stem cell treatment could help spinal cord injury and paralysis. Scientists remain hopeful, but currently there just hasnt been enough research done to substantiate any particular result. Additional research needs to be done before we have more definitive answers.

Again, we just dont know. Much of the answer depends upon whether the political process and moral debate continues to limitand put the hold onthe amount of research done. At this point its impossible to say for sure whenor even ifstem cells will be useful in the treatment of paralysis.

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Stem Cell Treatments - What options do I have?

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Stem Cell Therapy – Frequently Asked Questions

Posted: September 27, 2014 at 8:52 am

Our Technology

Mississsippi Stem Cell Treatment Center uses adipose derived stem cells for deployment & clinical research. Early stem cell research has traditionally been associated with the controversial use of embryonic stem cells. The new focus is on non-embryonic adult mesenchymal stem cells which are found in a persons own blood, bone marrow, and fat. Most stem cell treatment centers in the world are currently using stem cells derived from bone marrow.

A recent technological breakthrough enables us to now use adipose (fat) derived stem cells. Autologous stem cells from a persons own fat are easy to harvest safely under local anesthesia and are abundant in quantities up to 2500 times those seen in bone marrow.

Clinical success and favorable outcomes appear to be related directly to the quantity of stem cells deployed. Once these adipose derived stem cells are administered back in to the patient, they have the potential to repair human tissue by forming new cells of mesenchymal origin, such as cartilage, bone, ligaments, tendons, nerve, fat, muscle, blood vessels, and certain internal organs. Stem cells ability to form cartilage and bone makes them potentially highly effective in the treatment of degenerative orthopedic conditions. Their ability to form new blood vessels and smooth muscle makes them potentially very useful in the treatment of peyronies disease and impotence. Stem cells are used extensively in Europe and Asia to treat these conditions.

We have anecdotal and experimental evidence that stem cell therapy is effective in healing and regeneration. Stem cells seek out damaged tissues in order to repair the body naturally. The literature and internet is full of successful testimonials but we are still awaiting definitive studies demonstrating efficacy of stem cell therapy. Such data may take five or ten years to accumulate. In an effort to provide relief for patients suffering from certain degenerative diseases that have been resistant to common modalities of treatment, we are initiating pilot studies as experimental tests of treatment effectiveness with very high numbers of adipose derived stem cells obtained from fat. Adipose fat is an abundant and reliable source of stem cells.

Mississsippi Stem Cell Treatment Centers cell harvesting and isolation techniques are based on technology from Korea. This new technological breakthrough allows patients to safely receive their own autologous stem cells in extremely large quantities. Our treatments and research are patient funded and we have endeavored successfully to make it affordable. All of our sterile procedures are non-invasive and done under local anesthesia. Patients who are looking for non-surgical alternatives to their degenerative disorders can participate in our trials by filling out our treatment application to determine if they are candidates. Mississsippi Stem Cell Treatment Center is proud to be state of the art in the new field of Regenerative Medicine. RETURN TO TOP

We are currently in the process of setting up FDA approved protocols for stem cell banking in collaboration with a reputable cryo-technology company. This enables a person to receive autologous stem cells at any time in the future without having to undergo liposuction which may be inconvenient or contraindicated. Having your own stem cells available for medical immediate use is a valuable medical asset.

Provisions are nearly in place for this option and storage of your own stem cells obtained by liposuction at MSCTC or from fat obtained from cosmetic procedures performed elsewhere should be possible in the near future. RETURN TO TOP

Adult (NonEmbryonic) Mesenchymal Stem Cells are undifferentiated cells that have the ability to replace dying cells and regenerate damaged tissue. These special cells seek out areas of injury, disease and destruction where they are capable of regenerating healthy cells and enabling a persons natural healing processes to be accelerated. As we gain a deeper understanding of their medical function and apply this knowledge, we are realizing their enormous therapeutic potential to help the body heal itself. Adult stem cells have been used for a variety of medical treatments to repair and regenerate acute and chronicially damaged tissues in humans and animals. The use of stem cells is not FDA approved for the treatment of any specific disease in the United States at this time and their use is therefore investigational. Many reputable international centers have been using stem cell therapy to treat various chronic degenerative conditions as diverse as severe neurologic diseases, renal failure, erectile dysfunction, degenerative orthopedic problems, and even cardiac and pulmonary diseases to name a few. Adult stem cells appear to be particularly effective at repairing cartilage in degenerated joints. RETURN TO TOP

Regenerative Medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to damage, or congenital defects. This field holds the promise of regenerating damaged tissues and organs in the body by stimulating previously irreparable organs to heal themselves. (Wikipedia) RETURN TO TOP

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Stem Cell Treatment for Rheumatoid Arthritis | eHow

Posted: September 27, 2014 at 8:52 am

Daniel Cobalt

Daniel Cobalt lives in Georgia and has been writing online for over five years. He has a technical certificate in printing from the Philadelphia Printing School. His areas of expertise include fitness, home schooling, parenting, personal relationships, small business ownership and pet topics including breeding, training and responsible ownership.

Rheumatoid arthritis (RA) is a painful and potentially crippling disease. Stem cells are a type of cells that continue to grow and divide as long as the person or animal is alive and may be turned into other specific types of cells. Stem cell treatments are being used for many disorders, including RA. The stem cells can replace damaged cells and provide healthy growing cells free of the disease.

While stem cell treatments are a fairly new science, they can have life-saving effects. ... osteoarthritis, rheumatoid arthritis, spinal injuries and type...

Treatment includes anti-thyroid ... such as lupus and rheumatoid arthritis. ... blood cells, skin, heart and lungs. Rheumatoid arthritis is a inflammatory...

Dog owners now have the option of lessening the effects of arthritis on their dog's hip, elbow, knee or shoulder joints through...

Stem cell therapy has the potential to ... heart disease, diabetes and arthritis," according to the ... Stem cell research is a...

Stem Cell Treatment for Rheumatoid Arthritis. Rheumatoid arthritis (RA) is a painful and potentially crippling disease. Stem cells are a type of...

Parkinson's Stem Cell Treatment. ... How rheumatoid arthritis affects your spine can depend on the area of your spine that is affected--thoracic,...

Stem cell research originated in the 1980s within the field of biotechnology. ... rheumatoid arthritis Parkinson's disease spinal cord...

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New heart built with stem cells – YouTube

Posted: September 27, 2014 at 8:52 am

An entire functional heart was created using a heart 'shell' and stem cells. This has been done in the rat & pig, with hopes of using a pig's heart 'shell' for people. Livers, kidneys, and pancreas (much harder) are in the works.

They "injected the empty sac with heart cells from newborn rats. Within days, the cells had multiplied to flesh out the heart, which began beating on its own.

"We've taken organs from cadavers, removed all the cells, put cells back in and been able to reanimate what was previously a dead organ," said molecular biologist Doris Taylor, director of the Center for Cardiovascular Repair at the University of Minnesota.

"What that means, we hope, is that one day if you need a new organ, we'll be able to take your cells, transplant them into this framework or scaffold and build you an organ that works for you," she said. Read more at: http://www.thestar.com/sciencetech/Sc...

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New heart built with stem cells - YouTube

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University of Michigan Stem Cell Research | Frequently …

Posted: September 27, 2014 at 8:52 am

Frequently Asked Questions Michigan Law and President Obamas Executive Order Embryonic, Adult, and IPS (induced Pluripotent) Stem Cells Benefits of Stem Cell Research Embryo and Fetus Definitions Cloning Public Opinions Ethics Federally Approved Stem Cell Lines Stem Cells: Myth Vs. Fact

On Nov. 4, 2008, Michigan voters approved Proposal 2 by a margin of 53 percent to 47 percent. The ballot measure amended the state constitution, overturning a 1978 Michigan law that prohibited the use of human embryos for research, even if those embryos were to be discarded.

The law change enables Michigan researchers to derive new embryonic stem lines, using procedures already employed in laboratories around the world. The new state law allows the use of human embryos for research that is already permitted under federal law, provided that the embryos:

The new law makes Michigan one of just three states that protect stem cell research in the state constitution, while also enshrining specific restrictions. In addition to the restrictions listed above, the new law prohibits the buying or selling of embryos, as well as removing stem cells from embryos more than 14 days after cell division begins. It also requires the informed, written consent of embryo donors.

Michigans ban on human cloning was not altered by Proposal 2 and remains in full effect.

All human embryonic stem cell research at the University of Michigan will fully conform to the provisions of the new state constitutional amendment. In addition, U-M scientists will strictly adhere to the guidelines for the conduct of human embryonic stem cell research issued by the International Society for Stem Cell Research.

All stem cell research involving human subjects, including research in which embryos are donated for the derivation of stem cell lines, must be reviewed and approved by the University of Michigans Institutional Review Board. The board is a committee of ethicists, physicians, scientists and attorneys who review all aspects of the proposed research to ensure that is beneficial and ethically conducted.

All stem cell research must also be reviewed by the U-M Pluripotent Stem Cell Research Oversight Committee to independently ensure that all stem cell research projects are performed ethically.

On March 9, 2009, President Obama signed an executive order lifting the Bush administrations strict limits on federal funding for embryonic stem cell research. As a result, the federal government is expected to invest millions of dollars in new embryonic stem cell research.

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Pancreatic Cancer Stem Cell Research | University of …

Posted: September 27, 2014 at 8:52 am

Pancreatic cancer is one of the deadliest types of cancer. It is the fourth most common cause of cancer deaths in the United States. More than 43,000 people are diagnosed with pancreatic cancer each year and about the same number die each year from the disease. Only about 3% of people with pancreatic cancer live more than five years after diagnosis.

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There are several reasons why this type of cancer is so lethal

Scientists at the U-M Comprehensive Cancer Center are studying pancreatic cancer in an effort to find new and more effective treatments for patients with this deadly disease. In 2007, Cancer Center scientists were the first to identify a small group of cells, called cancer stem cells, in tumors from patients with pancreatic cancer. Researchers believe these stem cells are the key to finding an effective treatment and possibly someday a cure for pancreatic cancer.

U-M research shows that just a few cancer stem cells are responsible for the growth and spread of pancreatic cancer. Unless these stem cells are destroyed, the cancer will return. The goal of U-M scientists is to develop a new therapy targeted directly at cancer stem cells. If successful, it will be a major step forward in the treatment of pancreatic cancer.

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Since pancreatic cancer is resistant to chemotherapy and radiation, new treatments are needed that can kill the small number of cancer stem cells within the tumor. Studying pancreatic cancer stem cells will help researchers identify targets for new drugs or therapies, which can then be tested in animals and eventually in human clinical trials.

For more information about clinical trials, please contact our Cancer Answerline at 800-865-1125.

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Mass production of placenta stem cells gets FDA approval …

Posted: September 27, 2014 at 8:52 am

Published time: March 10, 2014 22:34

Reuters/Wolfgang Rattay

The US Food and Drug Administration has granted approval to Pluristem Therapeutics to mass produce therapeutic human-placenta-derived stem cell products within its commercial-scale manufacturing facility in Haifa, Israel.

Pluristems Placental Expanded (PLX) products are mesenchymal-like adherent stromal cells connective tissue cells in an organ from human placentas, which are lush with hormones and proteins. The FDA has cleared PLX for use in studies on treating injuries, one step closer to full approval of PLX cells in treatments.

PLX products are made via Pluristems automated 3D cell expansion manufacturing platform that uses its patented high-throughput culturing technologies, 3D bioreactors, and downstream equipment.

The PLX cells are grown using the companys proprietary 3D micro-environmental technology and are an off-the-shelf product that requires no tissue matching prior to administration, according to Pluristem.

Pluristem operates out of a high-output facility in northern Israel that can produce about 150,000 doses of PLX products a year.

"We believe we have the largest, scalable, most efficient, most consistent and controlled process for manufacturing cell therapies," Zami Aberman, chairman and CEO of Pluristem, said in a statement. "Knowing that the 'Process is the Product' in cell therapy, we have established our leadership position in the industry by focusing on our 3D commercial scale cell manufacturing processes.

Pluristems use of human placenta to boost cell repair involves a drug delivery platform that releases a cocktail of therapeutic proteins in response to a host of local and systemic inflammatory and ischemic diseases.

Though animal placenta, especially from horses, has been a popular form of treatment for cell repair, human placenta offers a naturally compatible genome.

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Inner Cell Mass – Embryonic Development & Stem Cells …

Posted: September 27, 2014 at 8:52 am

Embryonic Development of the Inner Cell Mass:

The fourth cleavage event of the developing embryo results in a nonpolarizedinner cell mass(ICM, pluriblast,embryoblast), enveloped by the outer, polarizedtrophoblastlayer of cells. The trophoblast cells form an inner cavity (blastocoele), whose formation indicates the bastocyst stage. While the trophoblast will ultimately form the outerchorionicsac and the fetal component of theplacenta, the inner cell mass, will give rise to all embryonic tissues and to some of the extraembryonic membranes.

The ICM segregates into abilaminar embryonic disc(bilaminar blastoderm) which consists of two epithelial layers, each of a distinct lineage: the external (dorsal)epiblastand the internal (ventral)hypoblast. The next developmental stage is gastrulation, in which waves of migrating cells convert the ICM into a trilaminar embryonic disc, which is comprised of three germ layers (ectoderm, mesoderm and endoderm) that contribute to the formation of many organs, often with contributions of two or all three of the germ layers.

The ectoderm forms the central andperipheral nervous systemsandepidermis, and contributes to theadiposeandheartas well as to numerous other organs. The ectoderm forms many of thesensory organs(eye, ear, nose), and is also the source of Rathke's pouch, an invaginating diverticulum of the stomodeal roof which ultimately detaches from the stomodeum and becomes the adenohypophysis of the pituitary gland.

The mesoderm produces and contributes to theblood,endothelium,heart,kidney,reproductive system,bones,skeletal, smooth muscleand connective tissues. The mesoderm also contributes totendons,ligaments,dermisandcartilage.

The endoderm produces thegut tubeand its derived organs, including the cecum, intestine, stomach, thymus, liver,pancreas,lungs,thyroidandprostate.

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Eye transplants and stem cells. – Artificial Eyes …

Posted: September 27, 2014 at 8:51 am

Science is slowly catching up with science fiction. Doctors can transplant the heart, lung, liver, kidneys and more recently hand transplants. Parts of the eye such as corneal transplants are also available.

The holy grail would be an eye transplant or the ability to regrow an eye with the help of stem cells. While there is no real prospect of achieving this in the near future there is continuing research working towards this end.

The three main impediments to transplanting a human eye are maintenance of donor eye viability, optic-nerve regeneration and restoration of topographic organisation, and avoidance of immunological rejection.

Reattaching the millions of nerves of the optic nerve to allow transfer of the information from the eye to the brain is the greatest impediment to achieving a viable eye transplant. If we are able to achieve this we still have the complications of restoring the circulation to the eye, balancing pressure of the transplanted eye and maintaining corneal health.

The earliest record of an eye transplant dates back to 1885 when a rabbit eye was transplanted into a human orbit. Since then there has been numerous attempts to transplant a mammalian eye. Although some of the studies establish success in other capacities, no visual function was recovered following transplantation.

There has been some success with eye transplantation performed in cold-blooded vertebrate.

A frog with the transplanted artificial eye on the left.

Professor Makoto Asashima of Tokyo University in Japan has used stem cell-like cells from a frog embryo to grow complete eyes which were then successfully transplanted into tadpoles.

Professor Asashima believes that his groundbreaking research could pave the way for the same procedure to be used to restore vision in humans.

So far, Professor Asashima and his team have transplanted new eyes into about 60 tadpoles, of which nearly three-quarters could then see. And 7 of the transplanted eyes have survived the metamorphosis from tadpole to frog.

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