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Phio Pharmaceuticals Announces Preclinical Data Demonstrating PH-762 Enhances Persistence of T cells for Tumor Cell Killing as Presented by Helmholtz…

Posted: September 25, 2022 at 2:14 am

MARLBOROUGH, Mass., Sept. 22, 2022 /PRNewswire/ -- Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a clinical stage biotechnology company developing the next generation of therapeutics based on its proprietary self-delivering RNAi (INTASYL) therapeutic platform, today announced that its research partner, Helmholtz Munich, presented preclinical data showing that Phio's lead clinicalproduct PH-762, an INTASYL compound targeting PD-1, increases the T cell population expressing stem cell-like characteristics, which in doing so, is expected to improve T cell persistence in vivo, therefore, resulting in enhanced duration of anti-tumor activity. These data were presented at the 9th Immunotherapy of Cancer Conference (ITOC) annual meeting, which is being held September 22 to 24, 2022 in Munich, Germany.

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"A well-known hurdle in adoptive cell therapy (ACT) with T cells is the poor persistence of effector T cells in patients, which are key players in killing tumor cells. These data demonstrate that PH-762 enhances the population of T cells that have more stem-like characteristics. As has been reported in literature, stem-like T cells are more resilient and result in an ACT product with prolonged tumor killing activity," said Dr. Simon Fricker, Phio's VP of Research and Development. "Increasing the frequency of this cell population by downregulating PD-1 using our PH-762 INTASYL compound is expected to enhance the population of T cells that fight cancer by increasing their proliferative activity, persistence, responsiveness and cell differentiation characteristics that are believed to improve the immune system's capacity to kill cancer cells."

"These new data complement the robust data set we've generated over the past several years for PH-762 in the treatment of melanoma by reducing the expression of PD-1, a clinically validated target for immunotherapy. Currently, Phio is conducting a first-in-human clinical trial of PH-762 to treat patients with advanced melanoma," concluded Dr. Fricker.

This preclinical study assessed the potential of PH-762 to downregulate PD-1 to increase the frequency of a CD8 T cell population with a stem-like associated marker profile. T cells were incubated with PH-762 and co-cultured with an autologous renal cell carcinoma tumor cell line. Results showed that PH-762 treatment reduced PD-1 surface expression in T cells compared to control and PH-762 mediated PD-1 silencing increased the population of T cells that expressed stem-like markers, including higher expression levels of certain surface markers that identify stem cell memory T cells.

ITOC is a European meeting providing a global platform for translational research in the field of immuno-oncology as well as a forum for discussion of early clinical translation and to address its unique challenges. The presentation detailing these data is titled, "RNAi mediated PD-1 knockdown induces a TCF-1 positive population in activated human CD8 T cells with stem-like associated marker profile."

About PH-762

PH-762 activates immune cells to better recognize and kill cancer cells by reducing the expression of PD-1, a clinically validated target for immunotherapy. PD-1 is expressed by T cells and prevents them from killing cancer cells. When PH-762 reduces PD-1 expression, the "brakes" on the immune system are released and T cells are activated to kill the cancer cells. PH-762 is being developed as a standalone drug therapy with local intratumoral administration. In addition, it is also being developed as a critical component of cellular immunotherapy, more specifically, to improve tumor cell killing capability of adoptively transferred tumor infiltrating lymphocyte (TIL) therapy.

AboutPhio Pharmaceuticals Corp.

Phio Pharmaceuticals Corp. (Nasdaq: PHIO) is a clinical stage biotechnology company developing the next generation of immuno-oncology therapeutics based on its self-delivering RNAi (INTASYL) therapeutic platform. The Company's efforts are focused on silencing tumor-induced suppression of the immune system through its proprietary INTASYL platform with utility in immune cells and the tumor microenvironment. The Company's goal is to develop powerful INTASYL therapeutic compounds that can weaponize immune effector cells to overcome tumor immune escape, thereby providing patients a powerful new treatment option that goes beyond current treatment modalities. For additional information, visit the Company's website, http://www.phiopharma.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as "intends," "believes," "anticipates," "indicates," "plans," "expects," "suggests," "may," "would," "should," "potential," "designed to," "will," "ongoing," "estimate," "forecast," "target," "predict," "could" and similar references, although not all forward-looking statements contain these words. Forward-looking statements are neither historical facts nor assurances of future performance. These statements are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements as a result of a number of important factors, including, but not limited to, the impact to our business and operations by the ongoing coronavirus pandemic, the development of our product candidates, results from our preclinical and clinical activities, our ability to execute on business strategies, our ability to develop our product candidates with collaboration partners, and the success of any such collaborations, the timeline and duration for advancing our product candidates into clinical development, the timing or likelihood of regulatory filings and approvals, the success of our efforts to commercialize our product candidates if approved, our ability to manufacture and supply our product candidates for clinical activities, and for commercial use if approved, the scope of protection we are able to establish and maintain for intellectual property rights covering our technology platform, our ability to obtain future financing, market and other conditions and those identified in our Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q under the caption "Risk Factors" and in other filings the Company periodically makes with the SEC. Readers are urged to review these risk factors and to not act in reliance on any forward-looking statements, as actual results may differ from those contemplated by our forward-looking statements. Phio does not undertake to update forward-looking statements to reflect a change in its views, events or circumstances that occur after the date of this release, except as required by law.

Contact Phio Pharmaceuticals Corp.[emailprotected]

Investor ContactAshley R. RobinsonLifeSci Advisors[emailprotected]

SOURCE Phio Pharmaceuticals Corp.

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Here Is Why You Heal Slower As You Age – Health Digest

Posted: September 25, 2022 at 2:14 am

You probably know what hormones are, and you may have at least heard about stem cells, but what is a growth factor? According to Britannica, it is a protein that stimulates growth in specific tissues. There are many types of growth factors, each with the job of repairing certain body parts. Some growth factors include epidermal growth factor (responsible for skin repair), platelet-derived growth factor (responsible for repairing muscles and connective tissues), and nerve growth factor (responsible for stimulating brain cell growth and repair).

According to a 2020 mini-review in Frontiers in Bioengineering and Biotechnology, growth factors are critical for tissue repair and regeneration. In short, growth factors help maintain skin health and heal wounds. As you age and fewer growth factors are available to help with repair and regeneration, injuries take longer to heal. Stem cells factor in because they release growth factors to instigate wound healing, according to a 2010 study in theInternational Journal of Stem Cells.

And the sex hormones estrogen and testosterone play a part in wound healing too. Low estrogen levels or high amounts of testosterone can slow healing. For women, estrogen levels drop after menopause, resulting in slowed healing time (via Wounds).

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September: er-blood | News and features – University of Bristol

Posted: September 25, 2022 at 2:14 am

Scientists from the University of Bristol and NHS Blood & Transplant (NHSBT) have discovered a rare new blood group system. The findings, published in Blood, the journal of the American Society of Hematology, also solve a 30-year mystery.

A persons blood type is determined by the presence or absence of proteins known as blood groups that are present on the surface of red blood cells. Although most people are familiar with the concept of blood groups such as ABO or Rh (the plus or minus), there are many other important blood groups. Where mismatch exists between one persons blood and that of another, the possibility of alloimmunisation (the process by which a person generates an antibody against a blood group antigen that they do not carry) arises. The presence of alloantibodies can have clinical consequences in transfusion or pregnancy by triggering an attack by the immune system

Researchers from Bristols School of Biochemstry and NHSBTs International Blood Group Reference Laboratory (IBGRL) spearheaded an international collaboration which sought to investigate a 30-year mystery surrounding the basis of three known, but genetically uncharacterised, antigens that did not fit into any known blood group system.

In this study, individuals with alloantibodies against a collection of antigens termed Er, that were first observed more than 30-years ago, were investigated by applying a powerful technique allowing simultaneous analysis of all their gene coding DNA sequences. Specific changes were identified in the gene coding for the Piezo1 protein, which would result in the production of an altered protein on the cell surface of these individuals. Using gene editing in an immortalised cell-line developed in Bristol, the Piezo1 protein was first removed and then reintroduced to definitively prove that alloantibodies to Er antigens (including two never before reported) bind to Piezo1, and that Piezo1 is required for Er antigen expression.

Using a combination of cutting-edge DNA sequencing and gene-editing techniques, the team were able to conclusively show that Piezo1, a protein of widespread biological interest, is the carrier for these sites (and more) and, in so doing, establish Er as a new blood group system.

Sadly, alloantibodies found in two pregnant women to two newly discovered Er antigens reported in this work were associated with tragic loss of their babies. Discovering the genetic basis of blood groups allows scientists to develop new tests to identify those with uncommon blood groups, with the aim of providing the best possible care for patients with even the rarest of blood types. Piezo1 is known to have important roles in both health and disease and, although there is still much for us to understand, the teams breakthrough further enhances our knowledge and represents another new milestone in blood sciences.

Dr Tim Satchwell, one of the studys lead authors at the University of Bristol, said: This study is a great example of how new technologies can combine with more traditional approaches to address long-standing questions that would have been impossible to answer not that many years ago. The fact that Er turned out to be Piezo1, a protein with such widespread interest makes it even more intriguing.

Professor Ash Toye, Professor of Cell Biology at the University of Bristol and Director of the NIHR Blood and Transplant Research Unit, said: This work demonstrates that even after all the research conducted to date, the simple red blood cell can still surprise us. Piezo proteins are mechanosensory proteins that are used by the red cell to sense when its being squeezed. The protein is present at only a few hundred copies in the membrane of each cell. This study really highlights the potential antigenicity of even very lowly expressed proteins and their relevance for transfusion medicine.

About NHS Blood and Transplant

NHS Blood and Transplant is a joint England and Wales Special Health Authority. We provide the blood and plasma donation service for England and the organ donation service for the UK. We also provide donated tissues, stem cells, and cord blood. NHSBT delivers specialist services to hospitals and carries out world leading research. We are an essential part of the NHS, saving and improving lives through public donation.

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Global Single Cell Analysis Market is Projected to Grow at a CAGR of 15.1% By 2032: Visiongain Reports Ltd – Yahoo Finance UK

Posted: September 25, 2022 at 2:14 am

Visiongain Reports Ltd

Visiongain has published a new report entitled the Single Cell Analysis 2022-2032. It includes profiles of Single Cell Analysis and Forecasts Market Segment by Type (Consumables, Instruments) Market Segment by Application, (Cancer, Immunology, Neurology, Stem Cell, Non-invasive Prenatal Diagnosis, In-vitro Fertilization, Others) Market Segment by Technique, (Flow Cytometry, Next Generation Sequencing, Polymerase Chain Reaction (PCR), Microscopy, Mass Spectrometry, Other Techniques) Market Segment by Cell Type, (Human Cells, Animal Cells, Microbial Cells) Market Segment by End Use, (Academic & Research Laboratories, Biotechnology and Pharmaceutical Companies, Hospitals and Diagnostic Laboratories, Others) PLUS COVID-19 Impact Analysis and Recovery Pattern Analysis (V-shaped, W-shaped, U-shaped, L-shaped) Profiles of Leading Companies, Region and Country.

The global single cell analysis market was valued at US$3,255.0 million in 2022 and is projected to grow at a CAGR of 15.1% during the forecast period 2022-2032.

Integration of Microfluidics in Single-Cell AnalysisSingle-cell analyses of various types are increasingly widely employed to solve a wide range of biological problems, and as their popularity grows, potential downsides to these methods become more evident. Workflows can be time-consuming, low-throughput, and prone to contamination, depending on the application.

Microfluidic designs have been widely used to enhance single-cell workflows in all major stages of single-cell applications, right from cell sorting to lysis, sample processing, and readout, owing to their advantages of high throughput, low reaction volume, and compatibility with bio-inert materials. However, creating an integrated microfluidic device that covers the complete single-cell operation from start to end remains difficult in the global market. In biology and chemistry, microfluidics has known to be a great tool for analysis of single cells in various end uses.

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How this Report Will Benefit You?Visiongains 570 page report provides 389 tables and 399 charts/graphs. Our new study is suitable for anyone requiring commercial, in-depth analyses for the global single cell analysis market, along with detailed segment analysis in the market. Our new study will help you evaluate the overall global and regional market for single cell analysis. Get the financial analysis of the overall market and different segments including type, application, technique, cell type, end use and capture higher market share. We believe that high opportunity remains in this fast-growing single cell analysis market. See how to use the existing and upcoming opportunities in this market to gain revenue benefits in the near future. Moreover, the report would help you to improve your strategic decision-making, allowing you to frame growth strategies, reinforce the analysis of other market players, and maximise the productivity of the company.

What are the Current Market Drivers?

Technological Advancements in Single-Cell Analysis ProductsThe advancement in the single cell amplification and manipulation techniques has resulted in the utilization of high output technologies in assays, resulting in augmented revenue. The implementation of single cell genomic or transcriptomic process for analysis in biomedical research has also increased due to the quick expansion of microfluidic equipment. Also, due to the technological innovations in sequencing techniques, the landscape of single-cell omics research, comprising transcriptomic, genomics, and epigenomics is changing. The ability to process a maximum number of samples has been assisted by substantial developments in sequencing repeatability together with reducing prices.

Growth in Stem Cell ResearchWith their self-renewal and plan potent differentiation potential, stem cells show great promise for therapeutic applications to some refractory diseases. such as myocardial infarction, stroke, and diabetes Owing to the heterogeneity of single cells, gene expression is highly diverse between cells even within a single tissue, making precise identification and analysis of biological properties difficult This hinders their further research and applications. However, single-cell analysis assists in characterizing and analyzing stem cells.

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Single-Cell Analysis Market Report 2022-2032

Where are the Market Opportunities?

High Growth Potential of Single-Cell SequencingRising growth of sequencing of individual cells is likely to exhibit huge potential opportunity for the market growth. It is a valuable technology for the identification of biomarkers, which are used to diagnose and track the onset and progression of a disease, as well as the patient's response to treatment. Companies are working on producing instruments and reagents that are suitable for single-cell sequencers since SCS technology delivers extensive details about genetic alterations.

Several sophisticated SCS instruments are projected to be developed and launched in the market in the future years, owing to the significant growth potential of this area.

Emergence of Asia Pacific Market

Rising investment in biology research across the global market along with the rising emphasis of key market players to expand their footprint in lucrative Asia Pacific region are the major factors propelling the market growth. Various economies in the region such as India, Japan, South Korea, and Southeast Asia in the region is anticipated to become driving force for expansion of single cell analysis market over the forecast period.

Several market players are investing in the development of cell based research facilities in emerging Asian countries. primarily due to the increasing prevalence of chronic diseases, improvements in infrastructural facilities for research, and favourable legislation for cell-based research. For instance, in June 2018, Agilent opened its new logistics hub in Shanghai to enable the faster delivery of supplies, consumables, and parts to laboratories in China.

Competitive LandscapeThe major players operating in the Single Cell Analysis market are Agilent Technologies, Inc., Beckman Coulter Inc., Becton, Dickinson and Company, Bio-Rad Laboratories Inc., Fluidigm Corporation, GE Healthcare, Illumina Inc., Merck KGaA, Qiagen NV, Thermo Fisher Scientific, Inc., Promega Corporation, Cytek Biosciences, Tecan Group Ltd., Sartorius AG, and Luminex Corporation. These major players operating in this market have adopted various strategies comprising M&A, investment in R&D, collaborations, partnerships, regional business expansion, and new product launch.

Recent Developments

2nd March 2021, Agilent entered into a definitive agreement to acquire Resolution Bioscience Inc. The acquisition helped to expand Agilents capabilities in NGS-based cancer diagnostics and provide with innovative technology to further accommodate the needs of the fast-growing precision medicine industry.

7th February 2021, Beckman Coulter Life Sciences Partners with Fry Laboratories and BioID Genomics on Next Generation DNA Sequencing

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Do you have any custom requirements we can help you with? Any need for a specific country, geo region, market segment or specific company information? Contact us today, we can discuss your needs and see how we can help: dev.visavadia@visiongain.com

About Visiongain

Visiongain is one of the fastest-growing and most innovative independent market intelligence around, the company publishes hundreds of market research reports which it adds to its extensive portfolio each year. These reports offer in-depth analysis across 18 industries worldwide. The reports cover a 10 year forecasts, are hundreds of pages long, with in depth market analysis and valuable competitive intelligence data. Visiongain works across a range of vertical markets, which currently can influence one another, these markets include automotive, aviation, chemicals, cyber, defence, energy, food & drink, materials, packaging, pharmaceutical and utilities sectors. Our customized and syndicatedmarket research reportsmean that you can have a bespoke piece of market intelligence customized to your very own business needs.

Contact:Dev VisavadiaPR at Visiongain Reports LimitedTel: + 44 0207 336 6100Email: dev.visavadia@visiongain.com

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Findings explain exceptional auditory abilities in Williams-Beuren Syndrome – EurekAlert

Posted: September 25, 2022 at 2:14 am

image:Brett Teubner Ph.D., Mary Patton Ph.D. and Christopher Davenport Ph.D., St. Jude Department of Developmental Neurobiology. view more

Credit: St. Jude Children's Research Hospital

Williams-Beuren syndrome (WBS) is a rare disorder that causes neurocognitive and developmental deficits. However, musical and auditory abilities are preserved or even enhanced in WBS patients. Scientists at St. Jude Childrens Research Hospital have identified the mechanism responsible for this ability in models of the disease. The findings were published today in Cell.

Understanding what causes the superior auditory ability in WBS patients may provide a target for treating the disease in addition to helping advance research on the ability to discriminate between sounds. WBS offers insight into the mechanisms that underlie enhanced auditory abilities. For instance, some people with WBS have perfect pitch, which is the ability to differentiate between notes or frequencies without a reference guide.

WBS stands out among neurodevelopmental disorders because children with the disorder, despite profound learning disabilities, can have a higher prevalence of superior musical and linguistic abilities than children in the general population, said corresponding author Stanislav Zakharenko, M.D., Ph.D., St. Jude Department of Developmental Neurobiology. We were fascinated by that and wanted to know more about how a disorder that is caused by a loss of 27 genes could help individuals gain a better than normal ability for auditory processing.

Excited neurons in the auditory cortex

Mouse models of WBS have an enhanced ability to discriminate between sound frequencies. These mice also have improved frequency coding in the auditory cortex, the part of the brain that processes sound. The researchers showed that the enhanced ability to discriminate between frequencies is caused by hyperexcitable interneurons in the auditory cortex.

To understand the cellular biology that underlies enhanced auditory abilities in WBS patients, the researchers conducted an RNAseq experiment. The data led the researchers to a neuropeptide receptor called VIPR1, which is reduced in the auditory cortex of individuals with WBS. The reduction in VIPR1 was also found in cerebral organoids, advanced models made in the laboratory using human induced pluripotent stem cells.

The scientists found that the transcription factor Gtf2ird1, encoded by one of the 27 genes lost in those with WBS, regulates VIPR1. Deleting or overexpressing VIPR1 in the auditory cortex can mimic or reverse the auditory effects seen in WBS. Thus, it is Gtf2ird1 downregulating VIPR1 that is responsible for the impact of WBS on auditory ability.

I didnt know a lot about VIPR1 before it popped up in our data because the role of this family of receptors in the brain is under-appreciated compared to other neuromodulator or neurotransmitter receptors, said first-author Christopher Davenport, St. Jude Department of Developmental Neurobiology. Our findings show that they can strongly impact information processing and behavior and are likely relevant for other behaviors and diseases as well.

This work suggests that reducing neuronal hyperexcitability might be a general mechanism for treating WBS through targeting VIPR1, Zakharenko said. It also opens up new directions to learn about musicality and how our brain differentiates sounds based on these findings in models of WBS.

Authors and funding

The studys other authors are Brett Teubner, Seung Baek Han, Mary Patton, Tae-Yeon Eom, Dusan Garic, Benjamin Lansdell, Abbas Shirinifard, Ti-Cheng Chang, Jonathon Klein, Shondra Pruett-Miller and Jay Blundon all of St. Jude.

The study was supported by grants from the National Institutes of Health (R01MH097742, R01DC012833), the Stanford Maternal and Child Health Research Institute Uytengsu-Hamilton 22q11 Neuropsychiatry Research Program and ALSAC, the fundraising and awareness organization of St. Jude.

St. JudeChildren's Research Hospital

St. JudeChildren's Research Hospital is leading the way the world understands, treats and cures childhood cancer and other life-threatening diseases. It is the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children. Treatments developed atSt. Judehave helped push the overall childhood cancer survival rate from 20% to 80% since the hospital opened 60 years ago.St. Judefreely shares the breakthroughs it makes, and every child saved atSt. Judemeans doctors and scientists worldwide can use that knowledge to save thousands more children. Families never receive a bill fromSt. Judefor treatment, travel, housing and food so families can focus on helping their child live. To learn more, visitstjude.orgorfollowSt. Judeon social media at@stjuderesearch.

Experimental study

Animals

Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice

23-Sep-2022

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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How Menopause Affects Cholesterol And What to Do About It – TIME

Posted: September 25, 2022 at 2:13 am

Kelly Officer, 49, eats a vegan diet and shuns most processed foods. So, after a recent routine blood test revealed that she had high cholesterol, I was shocked and upset, she says, since it never has been [high] in the past.

Officer is not alone. As women enter menopause, cholestrol levels jumpby an average of 10-15%, or about 10 to 20 milligrams per deciliter. (A healthy adult cholesterol range is 125-200 milligrams per deciliter, according to the National Library of Medicine.)

This change often goes unnoticed amidst physical symptoms and the general busyness of those years. But, says Dr. Erin Michos, director of womens cardiovascular health at Johns Hopkins Medicine, we need women to get screened and know their numbers. High cholesterol is a leading risk factor for heart disease, which kills more women in the U.S. than any other cause, including all forms of cancer combined. And the longer someone lives with high cholesterol, the greater the odds that it will build up in their arteries and cause a heart attack or stroke.

Many factors around midlife conspire to push cholesterol levels up, such as a sedentary lifestyle, less healthful diet, and weight gain. But the one that stands out as a clear driver of this shift is the sudden, unavoidable drop in estrogen levels at menopause. Unlike other issues that begin in perimenopausemood changes, hot flashes, fatiguethe rise in cholesterol tends to happen fairly suddenly, typically in the year before through the year after menopause.

Researchers are learning more about how and why this change happens, how better to screen for it, and the best treatments for women. But the first step is to acknowledge it. This is a normal transition, Michos says. And menopause marks an essential time for women to check in on their health.

Read More: How to Lower Your Cholesterol Naturally

Before women go through menopause, which typically arrives around age 51 in the U.S., they tend to have healthier cholesterol profiles and lower rates of cardiovascular disease than their male counterparts. But with the onset of menopause, that advantage drops off. By the time people reach their 60s and 70s, the rates of cardiovascular disease are almost even between sexes, with women surpassing men in this risk by their 80s. And women who go through menopause early are at an even higher risk sooner.

Estrogens protective effect on cholesterol is apparent even before menopause, as cholestrol levels rise and fall slightly with estrogen level fluctuations throughout each menstrual cycle. Researchers are still teasing out the details about how estrogen influences cholesterol, but much of it can be traced back to the liver, where estrogen receptors help to dictate a persons lipid profile.

The resulting patterns are clear: Once the body stops making as much estrogen, overall lipid profiles turn more harmful. Levels of bad cholesterol (low-density lipoproteins, or LDL) and triglycerides rise, and good cholesterol (high-density lipoproteins, or HDL) falters.

Even the remaining HDL might become less protective, says Samar El Khoudary, an associate professor at the University of Pittsburgh School of Public Health. Her research has shown that although HDL is a marker of decreased risk for heart disease before menopause, the opposite might be true after menopause. So its not just the quantity and balance of these particles, but also that the quality of these particles changes as women transition through menopause, she says.

The only way to determine cholesterol levels around menopause is to test for them. But predicting the timing is difficult. Menopause is usually only apparent once its over and a person has already gone a year without a period.

Current recommendations suggest most people at low risk for cardiovascular disease have their cholesterol checked every five years, starting at age 20. (Even children and adolescents should have baseline cholesterol screenings.) Experts advise additional testing if there is a family history of high cholesterol or there has been a substantial health change, such as abdominal weight gain, periods of high stress, or menopause.

Regular tests are important because heart disease risk goes up the longer high cholesterol remains untreated. And cholesterol can be a quiet killer: If you dont check, you dont know, says Dr. Samia Mora, a cardiovascular specialist and director of the Center for Lipid Metabolomics at Brigham and Womens Hospital and associate professor at Harvard Medical School.

Of course, not all women who go through menopause develop high cholesterol. If someones baseline cholesterol has been healthy, and if their other risk factors for heart disease are low, an average rise in cholesterol levels is usually not immediately worrying.

But additional testing might be warranted if cholesterol levels or other cardiovascular disease risk factors (such as family history, high blood pressure, diabetes, obesity, and smoking) are high. Other tests that doctors might recommend include a coronary calcium scan that measures the amount of plaque buildup in the arteries around the heart or a check of lipoprotein (a), which is a form of LDL that can reveal more about cardiovascular risks.

El Khoudary and others say that doctors should also start looking beyond standard lipid panels for more details about a persons cholesterol, including particles size, shape, and composition. Research has found that, for example, smaller particles of LDL are more harmful than larger ones. Such tests existEl Khoudary and others use them in researchbut they are harder to get through standard clinician visits. She says incorporating these details into care could be even more helpful for women as they transition through menopause and shape their health for the next decades of life.

Read More: Only 7% of Americans Have Optimal Heart Health, Study Says

For women whose cholesterol rises to unhealthy levels during menopause, lifestyle adjustments are usually the first recommendation. We cant avoid aging, we cannot avoid our genetics, but we can change our lifestyle to counteract these effects, Mora says.

Diet alone can impact cholesterol by 20 to 30 milligrams per deciliter. Even when diet alone cannot get someone into a healthy range, Michos likes to remind patients that their cholesterol would likely be even more harmful without the extra effort. And she sees plenty of women going through menopause who, even with vegan diets, ultimately need cholesterol-reducing medication.

Statins are the standard pharmaceutical treatment for people with high cholesterol, including those in menopause. But women are less likely to go on statins, due to a combination of health care providers being less likely to recommend them and women being less likely to agree to take them. This trend is unfortunate because women can get a greater benefit from statins than men do, says Dr. Patricia Best, a cardiologist at Mayo Clinic and the Womens Heart Clinic and an associate professor at Mayo Clinic College of Medicine and Science.

Best sees people get discouraged when their lifestyle efforts fail to generate healthy cholesterol levelsand many then avoid medications because taking them makes them feel like theyve failed. Its really important to understand that sometimes even if you do everything right, youre still going to end up needing a medication, Best says. That is not failure, she says. Starting on medication to manage high cholesterol is a success: The most important thing is to keep yourself healthy over the long haul.

Experts also warn that the way many doctors calculate the need for statins or other cholesterol treatment is based on a 10-year risk of a major event like a heart attack or stroke. But, particularly for women in midlife, these risk-scoring systems do not capture the lifetime risk and the years of accumulating risk leading up to that point. You dont want to wait until 65 to start instituting all of these preventive [measures] that are going to help for quality of life throughout the rest of her years, Mora says.

If a drop in estrogen prompts an increase in cholesterol, what about adding estrogen back into the body, such as with hormone replacement therapy? Typically taken as synthetic estrogen pills, hormone replacement therapy is frequently prescribed for hot flashes and other menopause symptoms. And many women who do take it see an improvement in cholesterol levels. However, its not recommended solely as a cholesterol drug, in part because estrogen also increases the risk for blood clots.

As with much of health, the best bet is prevention, which includes having a healthy lifestyle for as many years as possible. Its not just how high your cholesterol is now, but how long it has been high, Mora says. All of the years exposed to high cholesterol are cumulative. On the plus side, lifestyle interventions are also cumulative.

Read More: What to Know About High Cholesterol in Kids

Menopause often coincides with a potentially stressful and busy time in womens lives, when their careers are still in full swing, and they may be providing care for their offspring as well as their parents. Amid these pressures, women often put their own health aside, foregoing exercise and healthy foodand missing routine health care, including cholesterol checks.

But healthy habits during this period are particularly important, Best says. A little bit more exercise, a little bit more thoughtfulness [about] diet can really make a huge differencebecause its during the next decade that women are at a marked increased risk of heart disease.

The hard truth is that with the inevitable metabolic shifts during middle age, what used to work to stay healthy might not cut it anymore, Best says. Your body is changing, so you have to adapt.

When a shift in hormones is coupled with weight gain, thats your one-two punch that can lead to a high cholesterol readingoften for the first time in a womans life, Best says. This pattern has become even more familiar in the past couple of years. For example, although Officer used to exercise regularly, since the pandemic disrupted her previous routines, she says that healthy habit fell by the wayside, and she has now put on extra weight.

To help combat menopause-related cholesterol shifts, women dont need to start running marathons or even going fully vegan, Mora says. She recommends a heart-healthy diet, such as a Mediterranean diet, with plenty of fruits, vegetables, and whole grains and low amounts of processed foods and refined carbohydrates. Other often-overlooked lifestyle adjustments, she says, including getting enough sleep and managing stresswhich can help not just cholesterol but overall cardiovascular and metabolic health.

Mora, who is around menopause age herself, tries to follow smart lifestyle habits about 80-90% of the time. This means she eats lots of fruits and nuts and takes the stairs instead of the elevatorbut still eats the occasional dark chocolate bar. We get overwhelmed with trying to change everything at once, Mora says. All you need to do is institute a moderate amount of healthful lifestyle behaviors that you do consistently most of the time.

Best agrees that trying to make healthy decisions all the time can be daunting. Shes 53, the mother of two children, and married, and she holds multiple positions at the Mayo Clinic as well as with other professional groups. So I fully understand my patients when theyre like, Are you kidding me? How am I going to fit that in?

Best has been folding healthy activities into her daily life, such as cooking as a family or walking with her husband. Not only are these good for her own health, she says, but its good for everyone else in the family.

Despite these effortsand her own clinical expertiseeven Bests cholesterol went up during menopause. Its always disappointing, she says. She didnt lose her resolve though. Gaining weight and having worse cholesterol are expected, but you can also fight through all of those things.

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Stroke symptoms in men & women – Times of India

Posted: September 25, 2022 at 2:13 am

When the blood supply to the brain is interrupted or slowed, it results in a reduction in nutrients and oxygen, which causes a stroke. Within minutes, brain cells begin to degenerate. Another possible explanation is that the brains blood vessels burst, causing blood to accumulate and pressure to build up inside the brain.

Stroke symptoms like face drooping, arm weakness, and speech difficulty are frequently experienced by both men and women. Other common symptoms include balance or coordination issues as well as issues with one or both eyes vision. Additionally, a patient may occasionally experience symptoms of a mini-stroke or TIA (transient ischemic attack) that last only briefly. The majority of patients ignore these symptoms because they are brief and go away quickly, but if prompt medical attention is not received, a serious stroke may result.

However, some stroke symptoms in women can be undetectable or dismissed due to their subtlety.

Common symptoms of Stroke in Men and Women

Why are women more likely than men to have a stroke?

The risk of stroke rises with age. Women have a higher lifetime risk of developing stroke because they typically live longer than men do. A headache, difficulty walking, difficulty speaking and understanding what others are saying, paralysis or numbness of the face, arm, or leg are among the symptoms. Stroke symptoms are similar in men and women, but women are at higher risk for stroke because of pregnancy, preeclampsia, high blood pressure during pregnancy, birth control pills, hormone replacement therapy, aura-producing migraines, and irregular heartbeat in women over 75. (atrial fibrillation).

The following factors contribute to women having a higher risk of stroke:

Pregnancy: Pregnant women have a comparatively higher risk of stroke, with the third trimester and the postpartum period having the highest risk. People with high blood pressure should receive medication treatment and close observation.

Preeclampsia: Preeclampsia is a pregnancy complication that results in high blood pressure, proteinuria, which is an indication of kidney damage, or other symptoms of organ damage. Additionally, it raises the danger of a stroke later in life.

Birth Control Pills: Despite the fact that birth control pills have become significantly safer over time, women who are already at risk for stroke should still exercise extra caution. Before prescribing the medication, it is advised to have your blood pressure checked.

Hormone Replacement Therapy: In postmenopausal women, hormone replacement therapy should never be used to lower the risk of stroke. People who are taking hormone replacement therapy should exercise extra caution to avoid smoking, especially if they are female migraine patients who are most at risk of having a stroke.

Migraines with Aura: Younger women who suffer from migraine with aura are more likely to have an ischemic stroke, especially if they smoke or use oral contraceptives. Smokers who experience migraines with an aura should stop doing so right away.

Atrial fibrillation: Stroke risk among women over 75 is boosted by atrial fibrillation by 20%.

How to Identify Stroke?

The identification of the stroke can help patients to act F.A.S.T in receiving the therapy/ treatment they require. The most effective stroke treatments are only accessible if the stroke is noticed and diagnosed within three hours of the onset of symptoms. If patients do not arrive at the hospital on time, they may be ineligible for these services.

The main features helping in stroke identification are FAST

Treatment and diagnosis of Stroke

Every part of the body is controlled by the brain, so a brain injury can leave a person permanently disabled and bedridden. It is not just a disability to the patient but a burden to caregivers also as it causes financial and emotional burdens. Since treatment for stroke is usually started within the first 34.5 hours, it is crucial for patient attendants to record the time of stroke onset whenever possible. Depending on the type of stroke, a clot buster injection could be given during the first 3-4.5 hours to relieve the symptoms. In some cases, mechanical thrombectomy (clot retrieval with minimally invasive surgery) can now be performed to lessen the symptoms of a stroke even after the window period has passed.

When a patient is outside the window period, the most common forms of treatment for stroke are antiplatelet medications and statins (drugs that lower cholesterol).

Some of the test may include:

Physical Exam: The physical examination will involve a number of procedures, such as blood pressure monitoring, a neurological examination, and heart and blood vessel listening tests to determine the health of your cardiovascular and nervous systems.

Blood tests: Blood tests will check your bloods ability to clot quickly, your blood sugar levels (both high and low), and your infection status.

CT Scan. Using a series of X-rays, a CT scan can produce a detailed image of your brains that can reveal conditions like tumours, ischemic strokes, bleeding in the brain, and more.

MRI: A magnetic field and strong radio waves are used in an MRI to produce a precise image of the brain. Brain haemorrhages and ischemic stroke damage can both be found on an MRI.

Carotid ultrasound: In this test, sound waves produce precise images of the interior of the necks carotid arteries. This test reveals blood flow and the accumulation of fatty deposits (plaques) in the carotid arteries.

Cerebral angiogram: Through a tiny incision, typically in the groin, a thin, flexible tube (catheter) is inserted for this test, which involves guiding it through the major arteries and into the carotid or vertebral artery.

Echocardiogram: Sound waves are used in an echocardiogram to produce fine-grained images of the heart. An echocardiogram can identify the origin of any heart clots that may have caused a stroke by moving from the heart to the brain.

How to Prevent Stroke?

The good news is that approximately 4 out of 5 strokes can be avoided. Maintaining a healthy lifestyle is important to preventing stroke like regular exercise keeps the heart and blood vessels healthy and aids in maintaining a healthy weight. By regularly taking medications and leading a healthy lifestyle, blood pressure can be managed. Dietary cholesterol and saturated fat levels should be controlled and kept as low as possible. To control blood pressure, it is advised to increase the amount of fibre in your diet and reduce your salt intake. Its crucial to stop using tobacco and to stay away from secondhand smoke.

Rehabilitation is crucial during the recovery process after a stroke and typically begins within a day or two in the hospital. Rehabilitation eases the transition from the hospital to the patients home and can help stop further strokes. Everyone recovers from a stroke differently, and it can take anywhere from a few days to several months.

Views expressed above are the author's own.

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Turn back the clock with collaborative care solutions Peace Arch News – Peace Arch News

Posted: September 25, 2022 at 2:13 am

With our ever-increasing levels of stress, lack of sleep, poor diet and pollutants in our environment, our bodies are experiencing increasing strain.

The good news is that by bringing together traditional medicine and groundbreaking wellness therapies through programs such as biohacking, health weight management, hormone balancing and skin rejuvenation, it is possible to address the effects of age-related issues.

These various stressors can increase overall levels of stress hormones like cortisol, says Dr. Jean Paul Lim, from Ageless Living, with locations in Langley, Victoria and coming soon to Kelowna. This has a negative impact on the body by suppressing certain functions required for optimum health and wellness and can lead to weight gain, acne, inflammation, decreased sexual function, low energy, brain fog and a variety of diseases.

One of the various Biohacking treatments at Ageless Living is their hyperbaric oxygen chamber.

What is Biohacking?

The term biohacking refers to making small incremental changes that can have big effects on the bodys ability to optimally perform, Dr. Lim explores, pointing to tools such as their infrared sauna, hyperbaric oxygen chamber, pulsed electromagnetic field therapy and other therapies designed to encourage rejuvenation and increase performance.

What is Hormone Balancing?

Unlike earlier therapies like Hormone Replacement Therapy (HRT) that used animal hormones, our hormone balancing treatments use bio-identical hormone restoration, Dr. Lim says. This means they look chemically identical to our own natural hormones, and besides helping to boost our natural levels, may help reduce the risk of some chronic health conditions.

With physicians board-certified in anti-aging and regenerative medicine, Ageless Livings MD-directed hormone balancing and health weight programs can help both men and women of all ages achieve optimal health and function.

The team of professionals offer traditional medicine and groundbreaking wellness therapies as a collaborative care solution.

Initial consultation what to expect

Your Ageless Living physician will review your medical history and hormone cascade, and run some tests which may include serum, saliva and/or urine. You may also have a nutritionist do a full nutritional history review, review test results with your physician, and then theyll create your treatment plan.

The goal is not only to increase longevity, but also quality of life, allowing you to live your life to the fullest, Dr. Lim says.

Other clinics offer just aesthetics or hormone balancing, he says. We stand apart because we offer team-based, integrated solutions that bring all these tools and technologies together as a collaborative care solution.

Find out more on Facebook and Instagram, or book a treatment online.

Health and wellness

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Health benefits of flaxseed – Punch Newspapers

Posted: September 25, 2022 at 2:13 am

I ate plantain peels for the first time and I can now say that the taste is not bad at all. I was lucky to have it from a freshly cut plantain bunch. It was crispy and I love the crunchy sound it gave while I chewed. How did it feel when you tasted it?

This week, I will be talking about flaxseed. It is also called linseed and also spelt flax seeds. They are small edible seeds from the North American flax plant known as Linum usitatissimum (the specific epithet in its species name, usitatissimum, means most useful. It is in the family Linaceae. It occurs in two basic varieties/colours- brown and yellow (golden). It produces a vegetable oil which is one of the oldest commercial oils. Both the seed and oil are chock-full of protein. Not only do these seeds add a nutty flavour to dishes, they are also bursting with nutrients such as heart-healthy fats and fiber. The seed also contains phytoestrogens called lignans which are similar to the hormone estrogen.

It is used as egg replacement in recipes. A gel which can be applied on the skin and hair is made by boiling the seed. It is used as a dietary supplement to prevent constipation, diabetes, high cholesterol, heart disease, cancer, and several other conditions. It has possible anti-cancer compounds which are polyphenols that may help manage certain types of cancer including breast cancer. It may be able to help with your weight loss efforts because of its fiber content. It boosts the chances of conception by supporting normal ovulation and restoration of hormonal balance. It is good for post-menopausal women as it protects them from cardiovascular issues.

Let us see some of the benefits

Loaded with nutrients: Flaxseed is a good source of many nutrients including protein, fiber and omega-3 fatty acids. It is particularly high in thiamine, a B vitamin that plays a key role in energy metabolism as well as cell function. It is also a great source of copper which is involved in brain development, immune health and iron metabolism.

High in omega-3 fatty acids: Flaxseed is an excellent source of alpha-linolenic acid (ALA), a type of omega-3 fatty acid that is important for heart health. ALA is one of the two essential fatty acids that you must obtain from the food you eat since your body does not produce them. Animal studies suggest that the ALA in flaxseed may help reduce inflammation and prevent cholesterol from being deposited in your hearts blood vessels. A recent study in 8,866 people tied increased ALA intake to decreased cholesterol levels and a lower risk of ischemic heart disease which is related to narrowed arteries and type 2 diabetes.

May help protect against cancer: Flaxseed is rich in lignans which are plant compounds that have been studied for their potent cancer-fighting properties. Interestingly, this seed boasts 75800 times more lignans than other plant foods. Some studies associate flaxseed intake with a lower risk of breast cancer, particularly for postmenopausal women. Animal and test-tube studies also show flaxseed to protect against colorectal, skin, blood and lung cancer.

Rich in fiber: One tablespoon (7 grams) of ground flaxseed packs two grams of fiber which is around five per cent and eight per cent of the daily recommended intake for men and women respectively. It contains two types of fiber soluble and insoluble which get fermented by the bacteria in your intestines to support gut health and improve bowel regularity.

May lower cholesterol levels: According to a one-month study in people with peripheral artery disease, eating four tablespoons (30 grams) of milled flaxseed per day decreased levels of LDL (bad) cholesterol by 15 per cent. A 12-week study in 112 people with high blood pressure had similar findings, reporting that four tablespoons (30 grams) of flaxseed per day led to significant reductions in body mass index (BMI), total cholesterol and blood pressure.

May reduce blood pressure: Flaxseed is renowned for its ability to decrease blood pressure levels. A review of 15 studies found that supplementing with flaxseed products, including flaxseed powder, may significantly lower levels of both systolic and diastolic blood pressure.

May stabilise your blood sugar levels: According to a review of 25 studies, whole flaxseed may decrease blood sugar and prevent insulin resistance, a condition that impairs the bodys ability to regulate blood sugar levels effectively. This blood-sugar-lowering effect may be due to this seeds soluble fiber content. Research shows that soluble fiber slows the absorption of sugar in the blood which may reduce blood sugar levels.

May help you manage your weight: Several studies suggest that flaxseed may aid weight management. One older study found that a drink with flax fiber tablets containing 2.5 grams of soluble fiber reduced feelings of hunger and overall appetite. This is likely because soluble fiber slows digestion and increases feelings of fullness which may be especially useful if you are trying to lose weight. In fact, a large review of 45 studies found that supplementing with flaxseed resulted in significant reductions in body weight, BMI and belly fat.

Scientific studies

In a study titled, Treatment with flaxseed oil induces apoptosis in cultured malignant cells, by

Alison L. Buckner et al, these results indicated that flaxseed oil can specifically inhibit cancer cell growth and induce apoptosis in some cancer cells and suggests it has further potential in anti-cancer therapy.

In a study titled, Long-term consumption of flaxseed enriched diet decreased ovarian cancer incidence and prostaglandin Ein hens, by Erfan Eilati et al, the results demonstrated that there was a reduction in ovarian cancer severity and incidence in hens fed flaxseed diet.

In a study titled, Flaxseed lignans and polyphenols enhanced activity in streptozotocin-induced diabetic rats, by Dan Draganescu et al, the results displayed that flaxseed extract can serve as a promising additional therapy approach in managing diabetes.

Roast your seeds and grind them. Grinding will allow good nutrient absorption. Use all ground seeds at once. While there are no specific recommendations for flaxseed intake, 1-2 tablespoons a day is considered a healthy amount. Do not exceed four ground tablespoons. My favourite way of eating it is adding it to my smoothies. You can add it to your baked goods, add to your cereals and sprinkle on top of yoghurt. However, flaxseeds too have side effects if not consumed in moderation! There are conflicting answers to the question whether it is safe during pregnancy and lactation, the best is to avoid it if you are in these categories. Due to its high fiber content, it is important to drink plenty of fluid while taking it. Since it has blood sugar and blood pressure lowering effect, taking it while on medications for these conditions might lower blood sugar and blood pressure too much (this does not mean diabetics and people with high blood pressure should not take it).Due to its high omega-3 fatty acid, It may increase the effects of blood thinning medications. Taking flaxseed might decrease the effects of oral contraceptive drugs and estrogen replacement therapy.

Enjoy your flaxseed.

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Progesterone Market Size to Grow by USD 1.23 Billion, Rise in Research and Development of Progesterone Drugs -Technavio – Yahoo Finance

Posted: September 25, 2022 at 2:13 am

NEW YORK, Sept. 23, 2022 /PRNewswire/ -- One of the key trends in the progesterone market is the rise in research and development of progesterone drugs. Various players are expanding their research to develop new formulations of the existing female infertility drugs due to the significant unmet demand. For instance, MVT-602 targets the kisspeptin system to stimulate reproductive hormones. It can effectively treat many reproductive disorders such as PCOS and hypothalamic amenorrhea (HA).

Technavio has announced its latest market research report titled Global Progesterone Market 2022-2026

The progesterone market size is expected to grow by USD 1.23 billion. In addition, the growth momentum of the market will accelerate at a CAGR of 12.96% during the forecast period, according to Technavio.

Get a comprehensive report summary describing the market size and forecast along with research methodology. The FREE sample reportis available in PDF format

The increasing prevalence of breast cancer is driving the progesterone market growth. However, factors such as stringent regulations may challenge the market growth during the forecast period.

Progesterone Market: Type Landscape

By type, the market has been segmented into synthetic progesterone and natural progesterone. The synthetic progesterone segment will be the largest contributor to market growth during the forecast period. Synthetic progesterone drugs help regulate the monthly menstrual cycle. Therefore, the advantages of synthetic progesterone will accelerate the market growth during the forecast period.

Progesterone Market: Geographic Landscape

By geography, the market has been segmented into North America, Europe, Asia, and Rest of World (ROW). North America is going to have lucrative growth during the forecast period. About 43% of the market's overall growth is expected to originate from North America. The US and Canada are the key countries for the progesteronemarket in North America. The growth of the region is attributed to factors such as the rising prevalence of kidney, breast, or uterine cancer types and the rising population of menopausal women.

Story continues

Some Key Companies and their Offerings

AbbVie Inc., Alkem Laboratories Ltd., Aquatic Group, Bionpharma Inc., Blubell Pharma Group, Cadila Pharmaceuticals Ltd., Caesar and Loretz GmbH, Cipla Ltd., Dr. Reddys Laboratories Ltd., Estrellas Life Sciences Pvt. Ltd., Fagron NV, Glenmark Pharmaceuticals Ltd, Hikma Pharmaceuticals Plc, Intas Pharmaceuticals Ltd., Kiama Lifesciences, Lupin Ltd., Organon and Co., PROCAPS S.A, Teva Pharmaceutical Industries Ltd., Virtus Pharmaceuticals LLC, among others, are the main players in the market. The key offerings of some of these vendors are listed below:

Alkem Laboratories Ltd. -The company offers ULTIGEST SR 200MG TAB as medication for a hormone prescribed for replacement therapy in women who have passed menopause.

Aquatic Group - The company offers injection I.P Luteum Depot as progesterone drugs.

Bionpharma Inc. - The company manufactures progesterone drugs.

Blubell Pharma Group -The company offers BELGEST 500 and BELGEST N under the injection section as progesterone.

Cadila Pharmaceuticals Ltd. -The company offers ALGEST SR 400MG tab as progesterone drugs, which are made using milk-making glands to help in the menstrual cycle.

This report provides a full list of key vendors, their strategies, and the latest developments. Request a FREE PDF Sample Now

What our Reports Offer

Market share assessments for the regional-level and country-level segments

Strategic recommendations for the new entrants

Covers market data for 2021, 2022, until 2026

Market trends (opportunities, drivers, threats, challenges, investment opportunities, and recommendations)

Strategic recommendations in key business segments based on the market estimations

Competitive landscaping mapping the key common trends

Company profiling with financials, detailed strategies, and recent developments

Supply chain trends mapping the latest technological advancements

Related Reports

Women's Health Therapeutics Marketby Type and Geography - Forecast and Analysis 2022-2026: The women's health therapeutics market share is expected to increase by USD 30.35 billion from 2021 to 2026.

Stem Cell Umbilical Cord Blood (UCB) Marketby End-user and Geography - Forecast and Analysis 2022-2026: The stem cell umbilical cord blood (UCB) market share is expected to increase by USD 1.47 bn from 2021 to 2026.

Progesterone Market Scope

Report Coverage

Details

Page number

120

Base year

2021

Forecast period

2022-2026

Growth momentum & CAGR

Accelerate at a CAGR of 12.96%

Market growth 2022-2026

USD 1.23 billion

Market structure

Fragmented

YoY growth (%)

12.45

Regional analysis

North America, Europe, Asia, and Rest of World (ROW)

Performing market contribution

North America at 43%

Key consumer countries

US, Canada, Germany, UK, and France

Competitive landscape

Leading companies, competitive strategies, consumer engagement scope

Companies profiled

AbbVie Inc., Alkem Laboratories Ltd., Aquatic Group, Bionpharma Inc., Blubell Pharma Group, Cadila Pharmaceuticals Ltd., Caesar and Loretz GmbH, Cipla Ltd., Dr. Reddys Laboratories Ltd., Estrellas Life Sciences Pvt. Ltd., Fagron NV, Glenmark Pharmaceuticals Ltd, Hikma Pharmaceuticals Plc, Intas Pharmaceuticals Ltd., Kiama Lifesciences, Lupin Ltd., Organon and Co., PROCAPS S.A, Teva Pharmaceutical Industries Ltd., and Virtus Pharmaceuticals LLC

Market Dynamics

Parent market analysis, market growth inducers and obstacles, fast-growing and slow-growing segment analysis, COVID-19 impact and future consumer dynamics, and market condition analysis for the forecast period.

Customization purview

If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized.

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Table of Contents

1 Executive Summary

2 Market Landscape

3 Market Sizing

4 Five Forces Analysis

5 Market Segmentation by Type

6 Customer Landscape

7 Geographic Landscape

8 Drivers, Challenges, and Trends

9 Vendor Landscape

10 Vendor Analysis

11 Appendix

About Us

Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provide actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

ContactTechnavio ResearchJesse MaidaMedia & Marketing ExecutiveUS: +1 844 364 1100UK: +44 203 893 3200Email: media@technavio.comWebsite: http://www.technavio.com/

Global Teeth Whitening Market 2022-2026 (PRNewsfoto/Technavio)

Cision

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