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01 Cells and cell division 09 Embryonic stem cells – Video

Posted: September 24, 2014 at 12:40 am


01 Cells and cell division 09 Embryonic stem cells

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New Treatment May Prevent Diabetes After Pancreatitis Surgery

Posted: September 22, 2014 at 10:58 pm

New York, NY (PRWEB) September 22, 2014

Video: Preventing Diabetes After Pancreatectomy - Dr. Beth Schrope

NewYork-Presbyterian/Columbia University Medical Center now offers autologous islet cell transplantation, or auto islet surgery, to prevent diabetes in patients who require a total pancreatectomy. The hospital is the first center in the New York metropolitan area to offer this treatment.

Every year, roughly 87,000 people in the United States receive surgical treatment for pancreatitis, a debilitating condition that causes intense abdominal pain and, potentially, diabetes. Pancreatitis can be so painful that, in some cases, patients must have the entire pancreas removed. While surgery relieves pain in 90 percent of cases, patients are left without the ability to produce insulin, causing a difficult-to-treat form of Type 1 diabetes known as brittle diabetes.

In auto islet surgery, the patient's islet cells, which produce hormones that regulate the endocrine system, are extracted from the pancreas after it is removed. The cells are then processed and reinfused into the patients liver. When auto islet surgery is successful, the reinfused cells produce insulin, acting in place of the pancreas to regulate blood sugar.

The most recent findings show that about one third of patients require no insulin therapy after autologous islet transplantation, another third require some insulin therapy after the procedure, and the procedure is unsuccessful in preventing diabetes in the remaining third.

"The goal of pancreatectomy is to relieve pain," says Dr. Beth Schrope, gastrointestinal surgeon and assistant professor of surgery, NewYork-Presbyterian/Columbia University Medical Center, who specializes in the treatment of pancreatitis. Returning to normal activities and living without pain is a tremendous improvement in patients' quality of life. Now with islet transplantation, theres an added bonusthe possible prevention of diabetes."

NewYork-Presbyterian/Columbia University Medical Center is currently accepting patients for auto islet surgery, through a joint effort of NewYork-Presbyterian/Columbia's Pancreas Center and the Stem Cell Processing and Cell Therapy Laboratory of the Department of Pathology. Patients who need a total pancreatectomy for benign diseases (such as chronic pancreatitis) may be eligible for this procedure to avoid Type 1 diabetes.

NewYork-Presbyterian Hospital/Columbia University Medical Center

NewYork-Presbyterian Hospital/Columbia University Medical Center, located in New York City, is one of the leading academic medical centers in the world, comprising the teaching hospital NewYork-Presbyterian and its academic partner, Columbia University College of Physicians and Surgeons. NewYork-Presbyterian/Columbia provides state-of-the-art inpatient, ambulatory and preventive care in all areas of medicine, and is committed to excellence in patient care, research, education and community service. NewYork-Presbyterian Hospital also comprises NewYork-Presbyterian Hospital/Weill Cornell Medical Center, NewYork-Presbyterian/Morgan Stanley Childrens Hospital, NewYork-Presbyterian Hospital/Westchester Division, NewYork-Presbyterian/The Allen Hospital and NewYork-Presbyterian/Lower Manhattan Hospital. The hospital is also closely affiliated with NewYork-Presbyterian/Lawrence Hospital in Bronxville. NewYork-Presbyterian is the #1 hospital in the New York metropolitan area, according to U.S. News & World Report, and consistently named to the magazines Honor Roll of best hospitals in the nation. For more information, visit http://www.nyp.org.

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Program predicts placement of chemical tags that control gene activity

Posted: September 22, 2014 at 10:54 pm

PUBLIC RELEASE DATE:

21-Sep-2014

Contact: Susan Brown scinews@ucsd.edu 858-246-0161 University of California - San Diego @UCSanDiego

Biochemists working at the University of California, San Diego, have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. They describe their analysis and report results from its application to human embryonic cells in a paper published in Nature Methods online September 21.

"All of our cells have the same blueprint, the same DNA, although they serve separate functions," said John Whitaker, lead author of the report. "Skin cells protect, nerve cells send signals, and these differences emerge because different subsets of genes are active or silent within particular kinds of cells."

These patterns of activity are controlled by modifications of the DNA that do not alter its sequencechemical tags that influence which genes are read and which are skipped within a particular cell.

By comparing sequences with and without epigenomic modification, the researchers identified DNA patterns associated with the changes. They call this novel analysis pipeline Epigram and have made both the program and the DNA motifs they identified openly available to other scientists.

"The interplay between genetic and epigenomic regulation has only begun to be deciphered," said Wei Wang, professor of chemistry and biochemistry who directed the work. "This study revealed that there are specific DNA sequences that are recognized by DNA-binding proteins," which specify exactly where other enzymes place epigenomic marks.

The epigenome guides the development of complex organisms from single fertilized eggs. The researchers analyzed epigenomic patterns in human embryonic stem cells and four cell lineages derived from them to catalogue genetic elements that shape the epigenome during development.

Damage to the epigenome not only disrupts development, but can happen at any point in our lives and sometimes leads to illness. Identification of the DNA sequences that guide the placement of epigenomic could guide experimental analysis, the authors say. By editing DNA sequences that control epigenomic modifications, scientists could probe their functions and perhaps in the future mend epigenomic mistakes that cause harm. Susan Brown

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Germantown's Next Healthcare pairs with NFL player

Posted: September 22, 2014 at 10:54 pm

Company plans for the future of stem cell use

by Samantha Schmieder

Staff Writer

Next Healthcare Inc. of Germantown recently launched a partnership with Arizona Cardinals wide reciever Larry Fitzgerald to promote its newest venture, CelBank Pro to other professional athletes.

Next Healthcares CelBank is the collection of cell samples and storage of their blood, skin or stem cells to be used in the future. Stem cells are unspecialized cells that are able to renew themselves through cell division and can be scientifically manipulated to become another type of cell with a more specialized function. They offer hope to provide new ways to fight disease or injuries, according to the National Institutes of Health.

Essentially we are in the business of banking cells for people, Vin Singh, the founder and CEO of Next Healthcare, said.

While CelBank is geared toward anyone interested in using their own cells later in their life, CelBank Pro is geared toward sports players who are very likely to get injured or just worn down during their career.

Skin cells and stem cells are stored at a healthy time at someones life for later use in regenerative medicine, Singh said.

In 2006 and 2007, Singh, who lives in Boyds, heard about a method in Japan that was able to turn adult skin cells into stem cells. Singh decided to build Next Healthcare around these induced pluripotent stem cells, or iPS cells.

For me that was the real spark. I heard about that and thought, Wow, this is an amazing, revolutionary breakthrough, Singh said. Thats where the idea came from, what can we do with that technology. There has to be something that I can do for consumers to give them an advantage.

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Beat tennis elbow with stem cell injections: Patients are receiving jabs to heal hard-to-treat tendon injuries

Posted: September 22, 2014 at 9:49 pm

By Roger Dobson for the Daily Mail

Published: 18:06 EST, 22 September 2014 | Updated: 18:06 EST, 22 September 2014

Scientists believe stem cells will provide a more effective solution fortendon injuries

Patients are receiving jabs of their own cells in an attempt to heal hard-to-treat tendon injuries, such as tennis elbow.

The treatment, which has previously been used on injured racehorses, uses a patient's stem cells to super-charge the body's natural repair mechanisms.

Millions of Britons suffer tendon injuries. Tendons are the tough bands of tissue that connect muscle to bone. They can become damaged through wear and tear or injury, causing inflammation or tears.

Such damage is notoriously difficult to treat because tendons have a very poor blood supply, so healing compounds cannot reach the injury site. As a result, tough scar tissue often forms around the tendon, significantly hampering movement and flexibility.

Treatments include non-steroidal anti-inflammatory drugs (NSAIDs), steroid injections and physiotherapy, but experts say they have limited success. Scientists believe stem cells - which have the ability to turn into different types of cells in the body - will provide a more effective solution.

Early-stage laboratory studies, as well as reports from treating racehorses, have shown that, over several weeks, the stem cells encourage the growth of new tendon tissue and reduce scar tissue.

This may be because stem cells can recruit compounds called growth factors that help regenerate damaged tissue.

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Inflammatory Bowel Disease (IBD) & Stem Cell Research: Ophir Klein, UCSF – Video

Posted: September 22, 2014 at 9:48 pm


Inflammatory Bowel Disease (IBD) Stem Cell Research: Ophir Klein, UCSF
In his presentation to the California Stem Cell Agency (CIRM) governing Board, Dr. Ophir Klein, a CIRM grantee and UCSF researcher, detailed his lab #39;s work to understand how stem cells regulate...

By: California Institute for Regenerative Medicine

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BioKidz: the Children of the Stem Cell Revolution to go Global

Posted: September 22, 2014 at 9:44 pm

(PRWEB UK) 22 September 2014

BioKidz is a simple concept which aims to engage children in the importance of stem cell medicine. Aimed at an audience of 4-9 year olds, the company now aims to use it in the 21 countries in which it operates.

BioEden has been invited to speak with parents and teachers later this month, as the BioKidz site aims to be a good source of scientific information for primary school teachers.

The BioEden proposition is very simple one: harvest the stem cells from a naturally shed baby tooth, store the viable cells for future therapeutic use, and guarantee that the cells will be available when needed.

As stem cell medicine is now becoming commonplace, it is important that there is a stem cell match when needed. The easiest way to do this is by harvesting and storing one's own cells, and there is no easier way than from naturally shed teeth.

The company admits that they could be putting the ordinary tooth fairy out of business, but they hasten to add that BioKidz have their own hero in the form of a Super Tooth Fairy who works within their own stem cell laboratories.

Children can meet BioEden the Super Tooth Fairy by visiting http://www.bioeden.com.

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Mystery donor of $1 million for stem cell research in …

Posted: September 21, 2014 at 11:56 pm

BIRMINGHAM, Alabama -- It's a secret no more.

The donor who gave $1 million last spring to the newly formed Alabama Institute of Medicine has been revealed: Chris Drummond. (Think coal).

He's the youngest of seven children of coal magnate, Garry Neal Drummond, CEO of Drummond Company, one of the world's largest private companies.

His name was revealed to AL.com just ahead of a big fund-raising gala this evening at WorkPlay.

The big reveal was inevitable as it is disclosed in a new book by Tory Williams, co-founder of the private, nonprofit company which received the donation. She was unpacking boxes of the book at WorkPlay today to give away to the 176 guests at the sold-out event. The gala features entertainer Taylor Hicks. The moderator is Peter Wilderotter, president and CEO of the Christopher & Dana Reeve Foundation.

The 28-year-old Drummond is introverted and has reluctantly agreed to be named, Williams said.

But she said Drummond is excited about the potential that stem cell research both medically and economically for Alabama and hopes his donation will inspire others to give.

Willilams met Drummond through her husband, Ron Williams, a medical sales manager with Stryker Orthopaedics. The couple invited Drummond to go with them, along with AIM co-founder Roman Reed, to the 2013 World Stem Cell Summit in California.

"He [Drummond] was blown away," Williams said.

Drummond's million-dollar donation last March kick-started the Alabama nonprofit, which immediately funded three projects at the University of Alabama at Birmingham. For details go here.

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Fibroblast Growth Factor FGF & Stem Cells 360p – Video

Posted: September 21, 2014 at 2:45 pm


Fibroblast Growth Factor FGF Stem Cells 360p
to order your Laminine Pls txt/call Ronald Torrefiel +63 932 919 3383 Phils.

By: Ronald Torrefiel

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Bone paste could provide treatment for ostoeporosis

Posted: September 21, 2014 at 2:45 pm

About three million Briton currently suffer osteoporosis which is affected by a number factors such as genes, a lack of exercise and poor diet and results in about 60,000 hip, 50,000 wrist and 120,000 spinal fractures every year, according to the National Osteoporosis Society, costing about 1.7 billion in health and social care.

Dr Ifty Ahmed, a researcher at Nottingham University, said his team wanted to provide a preventative treatment, strengthening the bones of those at risk before they suffered a fracture.

Speaking at the Regener8 conference on regenerative medicine, in Leeds last week, he said: Our aim would be to use screening to spot people who are at risk, then strengthen their bones before they get fractures.

It means that rather than waiting until people have a fall and break something, we would try to stop that ever happening, along with the consequences, loss of independence, surgery and secondary illnesses.

Previous attempts have been made to find ways of strengthening thinning bones but the difficulties of protecting the fragile stem cells has meant no such treatments have yet been developed.

Dr Ahmeds team hope to overcome this problem by puncturing the tiny hollow spheres of calcium phosphate allowing the stem cells to migrate inside them where they are protected.

The experimental treatment has not yet been trialled on humans.

It would involve extracting stem cells from a patients bone marrow and mixing them with the microspheres before injecting the paste into the vulnerable bones.

Dr Ahmed said: "If it works, this kind of treatment could be done in a day.

Until now the team have been funded by the Engineering and Physical Sciences Research Council but they are now looking for a commercial partner.

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