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Newswise DALLAS Sept. 4, 2014 Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.

Researchers studying infertility in mouse models found that, unlike similar types of cells that develop into sperm, the stem cells that express PAX7 can survive treatment with toxic drugs and radiation. If the findings hold true in people, they eventually could lead to new strategies to restore or protect fertility in men undergoing cancer treatment.

Unfortunately, many cancer treatments negatively impact fertility, and men who receive such treatments are at high risk of losing their fertility. This is of great concern among cancer patients, said Dr. Diego H. Castrillon, Associate Professor of Pathology and Director of Investigative Pathology. The PAX7 stem cells we identified proved highly resistant to cancer treatments, suggesting that they may be the cells responsible for the recovery of fertility following such treatments.

Infertility, which the Centers for Disease Control estimates affects as many as 4.7 million men in the United States, is a key complication of cancer treatments, such as chemotherapy and radiation therapy.

The new findings, presented in the Journal of Clinical Investigation, provide valuable insight into the process of sperm development. Known as spermatogenesis, sperm development is driven by a population of immature stem cells called progenitors in the testes. These cells gradually mature into fully differentiated sperm cells. Dr. Castrillon and his team tracked progenitor cells that express the protein PAX7 in mouse testes, and found that these cells gradually give rise to mature sperm.

We have long known that male fertility is driven by rare stem cells within the testes, but the precise identity of these stem cells has been disputed, said Dr. Castrillon, who holds the John H. Childers, M.D. Professorship in Pathology. Our findings suggest that these rare PAX7 cells are the key cells within the testes that are ultimately responsible for male fertility.

Importantly, even after exposure to toxic chemotherapy or radiation treatments, the PAX7-expressing cells continued to divide and thus could contribute to restoring sperm development.

First author Gina Aloisio, a student in UT Southwesterns Medical Scientist Training Program, is the recipient of a Fellowship Award from the UT Southwestern Cecil H. and Ida Green Center for Reproductive Biology Sciences. Other UT Southwestern researchers involved in the work include Dr. Kent Hamra, Assistant Professor of Pharmacology; Dr. James Amatruda, Associate Professor of Pediatrics, Internal Medicine, and Molecular Biology, the Horchow Family Scholar in Pediatrics and holder of the Nearburg Family Professorship in Pediatric Oncology Research; Dr. Anita Sengupta, Assistant Professor of Pathology; Dr. Ileana Cuevas, Instructor of Pathology; Dr. Yuji Nakada, Instructor of Pathology; Abhijit Bugde, Department of Cell Biology; graduate student researchers Hatice Saatcioglu, Christopher Pea, and Hema Manjunath; and former UT Southwestern researchers Dr. Michael Baker, Dr. Edward Tarnawa, and Jishnu Mukherjee.

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UT Southwestern Scientists Identify Rare Stem Cells in Testis That Hold Potential for Infertility Treatments

By Daniella Walsh on September 04th, 2014

By Daniella Walsh | LB Indy

Leslies stem cell

Janet Dreyer earned a doctorate in molecular biology, but in her 50s enrolled at the Pasadena College of Art and Design and became hooked on art. After a hiatus from both science and art for travel, shes back to art, creating a work that combines her training in both fields, The Stem Cell Scientist.

Dreyers computer generated work came to life at the request of Laguna Beach glass and multi-media artist Leslie Davis, who organized The Art of Stem Cells. The show features conceptual works by 29 artists. Their themes address debilitating diseases and injuries and the work of scientists trying to find cures. The month-long exhibition opens Saturday, Sept. 6, at the Orange County Center for Contemporary Art in Santa Ana.

Dreyer delved into history when she built a mosaic for the show. The work includes references to the regenerating powers of the Egyptian scarab god Khepri, showing him rolling a cell instead of the sun, among other images. I chose the mosaic format because the tiles create a sense of motion reminding me of developing cells, Dreyer said.

The exhibitions opening and closing receptions will not only showcase what results when artists interact with 23 scientists, but also introduce art patrons to researchers and examples of their state-of-the art stem cell pursuits. Half of all proceeds will benefit research at the center, led for the past eight years by Dr. Peter Donovan, to whom the show is dedicated.

With a keen interest in science and particularly stem cell therapy, Davis has forged a connection to UC Irvines Sue & Bill Gross Stem Cell Research Center. But since 2005, Davis twin interests have yielded three other medical related art exhibitions, including one for Mission Hospital.

It was her brainpower that led to pairing center researchers with artists selected on the strength and nature of their work.

Read more from the original source:
Stem Cells Star in Marriage of Art and Science

Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells -- and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.

Researchers studying infertility in mouse models found that, unlike similar types of cells that develop into sperm, the stem cells that express PAX7 can survive treatment with toxic drugs and radiation. If the findings hold true in people, they eventually could lead to new strategies to restore or protect fertility in men undergoing cancer treatment.

"Unfortunately, many cancer treatments negatively impact fertility, and men who receive such treatments are at high risk of losing their fertility. This is of great concern among cancer patients," said Dr. Diego H. Castrillon, Associate Professor of Pathology and Director of Investigative Pathology. "The PAX7 stem cells we identified proved highly resistant to cancer treatments, suggesting that they may be the cells responsible for the recovery of fertility following such treatments."

Infertility, which the Centers for Disease Control estimates affects as many as 4.7 million men in the United States, is a key complication of cancer treatments, such as chemotherapy and radiation therapy.

The new findings, presented in the Journal of Clinical Investigation, provide valuable insight into the process of sperm development. Known as spermatogenesis, sperm development is driven by a population of "immature" stem cells called progenitors in the testes. These cells gradually "mature" into fully differentiated sperm cells. Dr. Castrillon and his team tracked progenitor cells that express the protein PAX7 in mouse testes, and found that these cells gradually give rise to mature sperm.

"We have long known that male fertility is driven by rare stem cells within the testes, but the precise identity of these stem cells has been disputed," said Dr. Castrillon, who holds the John H. Childers, M.D. Professorship in Pathology. "Our findings suggest that these rare PAX7 cells are the key cells within the testes that are ultimately responsible for male fertility."

Importantly, even after exposure to toxic chemotherapy or radiation treatments, the PAX7-expressing cells continued to divide and thus could contribute to restoring sperm development.

Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.

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Rare stem cells hold potential for infertility treatments

PUBLIC RELEASE DATE:

4-Sep-2014

Contact: Russell Rian russell.rian@utsouthwestern.edu 214-648-3404 UT Southwestern Medical Center

DALLAS Sept. 4, 2014 Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.

Researchers studying infertility in mouse models found that, unlike similar types of cells that develop into sperm, the stem cells that express PAX7 can survive treatment with toxic drugs and radiation. If the findings hold true in people, they eventually could lead to new strategies to restore or protect fertility in men undergoing cancer treatment.

"Unfortunately, many cancer treatments negatively impact fertility, and men who receive such treatments are at high risk of losing their fertility. This is of great concern among cancer patients," said Dr. Diego H. Castrillon, Associate Professor of Pathology and Director of Investigative Pathology. "The PAX7 stem cells we identified proved highly resistant to cancer treatments, suggesting that they may be the cells responsible for the recovery of fertility following such treatments."

Infertility, which the Centers for Disease Control estimates affects as many as 4.7 million men in the United States, is a key complication of cancer treatments, such as chemotherapy and radiation therapy.

The new findings, presented in the Journal of Clinical Investigation, provide valuable insight into the process of sperm development. Known as spermatogenesis, sperm development is driven by a population of "immature" stem cells called progenitors in the testes. These cells gradually "mature" into fully differentiated sperm cells. Dr. Castrillon and his team tracked progenitor cells that express the protein PAX7 in mouse testes, and found that these cells gradually give rise to mature sperm.

"We have long known that male fertility is driven by rare stem cells within the testes, but the precise identity of these stem cells has been disputed," said Dr. Castrillon, who holds the John H. Childers, M.D. Professorship in Pathology. "Our findings suggest that these rare PAX7 cells are the key cells within the testes that are ultimately responsible for male fertility." Importantly, even after exposure to toxic chemotherapy or radiation treatments, the PAX7-expressing cells continued to divide and thus could contribute to restoring sperm development.

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Original post:
Scientists identify rare stem cells that hold potential for infertility treatments