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Hope for future treatment of thousands of stroke sufferers from stem cells

Posted: August 10, 2014 at 1:48 pm

"So we said what about the other 90 per cent?"

The team targeted patients who had suffered massive strokes involving a blood clot in the blood vessel in the middle of the brain. Typically there is a high mortality rate in these patients and those who survive are often severely disabled, are unable to walk, talk, feed or dress themselves.

The experimental procedure was carried out on five patients aged between 40 and 70, all of whom showed improvement over the following six months and three were living independently.

More than 152,000 people suffer a stroke in England per year and the research team said that the new procedure could eventually help most of them.

Dr Madina Kara, a neuroscientist at The Stroke Association, said: Previous studies have shown that a type of stem cell, called CD34+ cells, shows promise to aid stroke recovery. These latest results suggest that this type of treatment could be administered safely and were looking forward to seeing the outcomes of further studies to see exactly how they are aiding recovery.

This is one of the most exciting recent developments in stroke research; however, its still early days in stem cell research but the findings could lead to new treatments for stroke patients in the future.

"In the UK, someone has a stroke every three and half minutes, and around 58 per cenrt of stroke survivors are left with a disability.

"One of the few existing treatments which can limit brain damage caused by stroke is thrombolysis. However, this drug can only be used to treat strokes caused by blood clots and must be administered within the first 4.5 hours after a stroke. There is an urgent need for alternative treatments to help prevent the debilitating impact of stroke."

The experimental procedure involves several stages, first the patient's own bone marrow is harvested, which was then sent to a specialist laboratory so the specific stem cells, called CD34+ can be selected.

Then the patient undergoes a procedure in which a wire is inserted into a vein in the neck and up into the area of brain damage. Once there the stem cells are released and the wire retracted.

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Stem cell hope for stroke victims

Posted: August 10, 2014 at 1:48 pm

Brain damage caused by strokes could be repaired through the use of stem cells in a discovery that may revolutionise treatment, a study has suggested.

Researchers at Imperial College London found that injecting a patient's stem cells into their brain may be able to change the lives of the tens of thousands of people who suffer strokes each year.

Their results have been called "one of the most exciting recent developments in stroke research".

Doctors said the procedure could become routine in 10 years after larger trials are conducted to examine its effectiveness.

Researcher Dr Paul Bentley, from the college's Department of Medicine, said: "Currently, the main form of treatment is an unblocking of the blood vessel, and that only helps one-third of the patients who are treated and only 10 per cent are eligible anyway. So we said, 'What about the other 90 per cent?' "

The team targeted patients who had suffered severe strokes involving a clot in a blood vessel in the middle of the brain. Typically, there is a high mortality rate in these patients and those who survive are often severely disabled, unable to walk, talk, feed or dress themselves. The experimental procedure was carried out on five such patients, aged 40 to 70, all of whom showed improvement over the following six months, and three were living independently.

Dr Madina Kara, a neuroscientist at the Stroke Association, said: "This is one of the most exciting recent developments in stroke research. However, it's still early days in stem cell research, but the findings could lead to new treatments for stroke patients in the future.

"In the UK, someone has a stroke every three and a half minutes, and around 58 per cent of stroke survivors are left with a disability."

The experimental procedure involved harvesting the patient's own bone marrow, which was then sent to a specialist laboratory so specific stem cells, called CD34+, could be selected. The patient then has a wire inserted into the area of the brain damage. Once there, the stem cells are released and the wire retracted. During the trials the whole process took half a day, but it is hoped that with refinement it could be reduced.

It is thought the cells work in two ways: by growing into small blood vessels that allow the brain to grow new nerves and brain tissue surrounding them, and by releasing anti-inflammatory chemicals that encourage tissue repair.

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Stem cell hope for stroke victims

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Global Stem Cells Group and Regenestem Announce Launch of Stem Cell Treatment Center in Cozumel, Mexico

Posted: August 10, 2014 at 1:43 pm

Miami (PRWEB) August 10, 2014

Regenestem, a division of the Global Stem Cells Group, Inc., has announced the launch of a new stem cell treatment center in Cozumel, Mexico, offering the most advanced protocols and techniques in cellular medicine to patients from around the world.

A team of stem cell medical professionals led by Rafael Moguel, M.D., an advocate and pioneer in the use of stem cell therapies to treat a range of medical conditions, will provide cutting edge therapies and follow-up treatment under the Regenestem brand.

In June, Global Stem Cells Group opened the Regenestem Asia Clinic in Manila, Philippines, adding a new state-of-the-art regenerative medicine facility to the company's growing global presence that includes clinics in Miami, New York, Los Angeles, and Dubai. Regenestem Asia facility marks the first Regenestem brand clinic in the Philippines.

Regenestem provides stem cell treatments for a variety of diseases and conditions, including arthritis, autism, chronic obstructive pulmonary disease (COPD), diabetes, and multiple sclerosis at various facilities worldwide. Regenestem Mexico will have an international staff experienced in administering the leading cellular therapies available.

Regenestem Mexico is certified for the medical tourism market, and staff physicians are board-certified or board-eligible. Regenestem clinics provide services in more than 10 specialties, attracting patients from the United States and around the world.

The Global Stem Cells Group and Regenestem are committed to the highest of standards in service and technology, expert and compassionate care, and a philosophy of exceeding the expectations of their international patients.

For more information, visit the Regenestem website, email info(at)regenstem(dot)com, or call 305-224-1858.

About Regenestem:

Regenestem, a division of the Global Stem Cells Group, Inc., is an international medical practice association committed to researching and producing comprehensive stem cell treatments for patients worldwide. Having assembled a highly qualified staff of medical specialistsprofessionals trained in the latest cutting-edge techniques in cellular medicineRegenestem continues to be a leader in delivering the latest protocols in the adult stem cell arena.

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Global Stem Cells Group and Regenestem Announce Launch of Stem Cell Treatment Center in Cozumel, Mexico

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Stem cell treatment holds hope for better stroke recovery

Posted: August 10, 2014 at 1:43 pm

A new first-of-its kind pilot study has revealed that stem cell treatment can significantly improve recovery from stroke in humans.

The therapy uses a type of cell called CD34+ cells, a set of stem cells in the bone marrow that give rise to blood cells and blood vessel lining cells. Rather than developing into brain cells themselves, the cells are thought to release chemicals that trigger the growth of new brain tissue and new blood vessels in the area damaged by stroke.

The patients were treated within seven days of a severe stroke, in contrast to several other stem cell trials, most of which have treated patients after six months or later. The Imperial researchers believe early treatment might improve the chances of a better recovery.

Dr Soma Banerjee, Consultant in Stroke Medicine at Imperial College Healthcare NHS Trust, said that the treatment appeared to be safe and that it's feasible to treat patients early when they might be more likely to benefit.

However, it's too early to draw definitive conclusions about the effectiveness of the therapy and more tests to work out the best dose and timescale for treatment before starting larger trials, she further added.

The study is published in the journal Stem Cells Translational Medicine.

(Posted on 09-08-2014)

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Stem cell treatment holds hope for better stroke recovery

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Orthopedic Stem Cell Therapy – Video

Posted: August 9, 2014 at 5:47 pm


Orthopedic Stem Cell Therapy

By: Dave Locke

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Orthopedic Stem Cell Therapy - Video

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Lorna Tolentino reveals the secret to her youthful looks

Posted: August 9, 2014 at 5:47 pm

Kasi kaka-quit ko lang ng smoking, Lorna Tolentino proudly announces.

The 52-year-old actress also adds, Mag-wa-one month na sa August 14.

Asked whether shes having a hard time adjusting her lifestyle, she says, Ay no, hindi naman talaga ako ganun Im not really talaga sobrang sobrang smoker.

Right now, Lorna is taking supplements such as vitamin B1, B complex, glutathione, and mangosteen and malunggay capsules.

Siyempre nung nag-50 ako, mas iniisip ko na mas tumagal pa.

Kasi siyempre, 'di ba, gone too soon si Rudy [Fernandez], kaya siyempre kailangan mas mahaba pa, lalo na because of my apo, yun ang nag-i-inspire sa akin, she confesses.

When asked whether shes ok with Lyla Victoria, Raphael's (Lorna's eldest son) daughter, entering showbiz, Lorna answers, Commercial kung meron, oo tatangapin ko.

Lorna enthusiastically talks about her two-year-old apo, whom she refers to as still being in her makulit stage, Shes ok, actually yung kanya intellectual [maturity] ano, something na pinapaano sa mga doctor, for four years old na.

She also complements Leana, Lylas mother, for teaching her grandchild, Talagang kinu-congratulate ko si Leana, because shes a teacher, talagang mas kaya niya i-guide.

STEM CELL THERAPY.Lorna Tolentino, who has undergone stem cell therapy, narrates how the procedure helped her health concerns.

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Lorna Tolentino reveals the secret to her youthful looks

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3 methods for passaging of pluripotent stem cells – Video

Posted: August 9, 2014 at 1:42 pm


3 methods for passaging of pluripotent stem cells
Here are 3 methods for passaging of pluripotent stem cells, or PSCs, including our recommended method using StemMACS iPS-Brew XF, for minimal stress to cells and less hands-on time. Learn more...

By: Miltenyi Biotec

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3 methods for passaging of pluripotent stem cells - Video

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Experiment at Fred Hutch raises hopes in battling brain tumors

Posted: August 9, 2014 at 12:48 pm

A gene-therapy experiment at Fred Hutchinson Cancer Research Center only involved a handful of brain-tumor patients, and on average, extended their lives by months, not years.

Even so, it was the first real progress in 30 years for patients with glioblastoma, the most common and most aggressive type of primary brain tumor the type that killed U.S. Sen. Edward Kennedy within 15 months of diagnosis.

I think this is actually one of those proof-of-concept milestones, said Dr. Stanton Gerson, director of the Case Comprehensive Cancer Center at Case Western Reserve University in Cleveland, who was not involved in the study. This is the very first clinical validation that all that science made sense.

The new approach, led by Dr. Hans-Peter Kiem and Dr. Jennifer Adair at Fred Hutch in Seattle, was published Friday in The Journal of Clinical Investigation.

It began with the usual therapy for such tumors powerful chemotherapy combined with a drug that disables a protein that makes some of these tumors particularly resistant to chemotherapy. More than half the patients with glioblastomas, including all seven patients enrolled in the study, have such a protein, Kiem said.

The protein-disabling drug, benzylguanine, is critically important because it allows chemotherapy to attack the tumor. But the drug also damages bone marrow, killing blood cells so people are left vulnerable to infection and bleeding, he said. For that reason, patients typically can receive only one or two cycles of chemotherapy.

The gene-therapy approach involved taking the patients stem cells and engineering them to become resistant to benzylguanine, so their blood cells werent damaged by the drug. When the stem cells were returned to the patients, their blood was protected but their tumors were left vulnerable to the chemotherapy.

Better protected against infection and bleeding, the seven patients in the study were able to receive more cycles of chemotherapy.

We can sensitize the tumor, while the blood cells are resistant, Kiem said. That is the trick.

Typical median survival for glioblastoma patients with the tumor-protecting protein is less than 13 months. The patients in this study, on average, survived 20 months, and all survived beyond one year. This is quite remarkable, he said.

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ARTAS FUE Hair Transplant and Stem Cell Therapy – Video

Posted: August 9, 2014 at 12:44 pm


ARTAS FUE Hair Transplant and Stem Cell Therapy
Dr. William Yates speaks with another happy patient showing great results after a 2000 graft hair transplant utilizing the ARTAS FUE Robotic Hair Transplant ...

By: William Yates

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ARTAS FUE Hair Transplant and Stem Cell Therapy - Video

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Stem Cell Therapy – Am I A Candidate – Video

Posted: August 9, 2014 at 12:44 pm


Stem Cell Therapy - Am I A Candidate
Farhan Saddiqi, MD discusses the process of determining whether you are a candidate for Stem Cell Therapy at the Trinity Stem Cell Institute.

By: SMU Productions - Tampa Video Production

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