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RoosterBio Inc, a Frederick Maryland Biotech Startup, Achieves Rapid Traction with Product Launch and Fundraising …

Posted: February 25, 2014 at 1:44 pm

Frederick, MD (PRWEB) February 25, 2014

RoosterBio Inc is a new biotech start-up supplying human bone marrow-derived Mesenchymal Stem Cells (hBM-MSC) for tissue engineering research and stem cell-based product development into the high growth Synthetic Biology and Regenerative Medicine fields. RoosterBio, Inc. initiated laboratory operations in October, 2013, and has achieved the critical milestone of first product shipment to paying customers in just four short months. In addition to the early validation of their business model and rapidly generating revenue, Roosterbio has raised over 250K in seed investment and are actively seeking funds via AngelList (https://angel.co/roosterbio).

RoosterBio credits their quick-to-market accomplishments to hyper-efficient operations and the passion that the RoosterBio team shares in their desire to assist tissue engineers and cell therapists to accelerate life-saving technologies into the clinic. Our laser focus coupled with operational excellence has enabled us to reach these milestones; we will delight our customers with our product offering, says Chief Operating Officer, Dr. Uplaksh Kumar. The RoosterBio teams extensive experience sourcing raw materials, manufacturing stem cell products, and controlling for high quality with best-in-class characterization techniques has allowed them to successfully launch their flagship hBM-MSC product quickly and efficiently.

Dr. Jon Rowley, RoosterBios Chief Executive said I cant express how proud I am of our small, highly dedicated team that worked tirelessly to get our first products designed, manufactured, quality tested, released, and just as importantly sold and shipped to our first paying customers. This was truly a team effort that couldnt have been done without each and every person at RoosterBio.

Having spent years as cell and tissue technologists, the RoosterBio team has an intimate understanding of the pain points surrounding the generation of large numbers of robust, reproducible, standardized cells for research and product development purposes. RoosterBio products are designed to solve this problem and they believe that high volume and affordable cellular raw materials will kick-start the cell-based medical product revolution.

Dr. Sarah Griffiths, a Researcher at Georgia Tech in Atlanta, believes that RoosterBios MSCs will do exactly that, and was anxiously awaiting receipt of the product. "We are excited to receive the first shipment of RoosterBios product. The potential to generate large stocks of MSCs in a short period of time will be a tremendous advantage to the progress of our research."

Researchers in the fields of Synthetic Biology and Regenerative Medicine, such as Dr. Griffiths, will use RoosterBios MSCs to develop new medical therapies to provide treatments for degenerative diseases such as Parkinsons and Alzheimers diseases, or to repair or replace tissue after a catastrophic injury such as traumatic bone and cartilage injury, spinal cord damage, heart attack, or significant burns.

RoosterBios current focus is to supply high volume research-grade cells manufactured with processes consistent with current Good Manufacturing Practices (cGMP). They are rapidly approaching their next milestones by laying the groundwork for initiating production of clinical-grade cells to be used in translational R&D and clinical studies.

About RoosterBio RoosterBio is focused on building a robust and sustainable Regenerative Medicine industry. Our products are affordable and standardized primary cells and media, manufactured and delivered with highest quality and in formats that simplify product development efforts. RoosterBio products are made with care in Frederick, MD, and will accelerate the translation of cell therapy and tissue engineering technologies into the clinic.

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Medeniyet Konferansn "nsan Kanser Kk Hcreleri (Human Cancer Stem Cells: Fact or Fiction)" – Video

Posted: February 25, 2014 at 3:43 am


Medeniyet Konferansn "nsan Kanser Kk Hcreleri (Human Cancer Stem Cells: Fact or Fiction)"
12 ubat 2014 tarihinde niversitemiz Gztepe-Kuzey Yerlekesinde gerekleen konferansta Dr. James A. Radosevich #39;in, "nsan Kanser Kk Hcreleri (Human Canc...

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Spontaneously contracting former stem cells – Video

Posted: February 25, 2014 at 3:43 am


Spontaneously contracting former stem cells

By: Michelle Sener

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Spontaneously contracting former stem cells - Video

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Are stem cells from osteoarthritis patients able to differentiate – Video

Posted: February 25, 2014 at 3:43 am


Are stem cells from osteoarthritis patients able to differentiate
http://www.arthritistreatmentcenter.com Are stem cells in patients with osteoarthritis less able to differentiate? J Mary Murphy and colleagues published an ...

By: Nathan Wei

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Are stem cells from osteoarthritis patients able to differentiate - Video

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Stem Cells Autism Ethan 02/2014 – Video

Posted: February 25, 2014 at 3:43 am


Stem Cells Autism Ethan 02/2014
Here is Ethan riding bike with neighbors. It #39;s great to see him recover from a fall with humor. Before, he would have had a meltdown and we would have had to...

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Stem Cells Autism Ethan 02/2014 - Video

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Obama Lifts Ban On Federal Funding For Stem Cell Research – Video

Posted: February 25, 2014 at 3:43 am


Obama Lifts Ban On Federal Funding For Stem Cell Research
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Scientists Transform Skin Cells Into Functioning Liver Cells

Posted: February 25, 2014 at 1:46 am

Gladstone Institutes

Joint Gladstone-UCSF study highlights novel reprogramming method; offers new hope for treating liver failure

SAN FRANCISCO, CAFebruary 23, 2014 The power of regenerative medicine now allows scientists to transform skin cells into cells that closely resemble heart cells, pancreas cells and even neurons. However, a method to generate cells that are fully maturea crucial prerequisite for life-saving therapieshas proven far more difficult. But now, scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF), have made an important breakthrough: they have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own, even after being transplanted into laboratory animals modified to mimic liver failure.

In previous studies on liver-cell reprogramming, scientists had difficulty getting stem cell-derived liver cells to survive once being transplanted into existing liver tissue. But the Gladstone-UCSF team figured out a way to solve this problem. Writing in the latest issue of the journal Nature, researchers in the laboratories of Gladstone Senior Investigator Sheng Ding, PhD, and UCSF Associate Professor Holger Willenbring, MD, PhD, reveal a new cellular reprogramming method that transforms human skin cells into liver cells that are virtually indistinguishable from the cells that make up native liver tissue.

These results offer new hope for the millions of people suffering from, or at risk of developing, liver failurean increasingly common condition that results in progressive and irreversible loss of liver function. At present, the only option is a costly liver transplant. So, scientists have long looked to stem cell technology as a potential alternative. But thus far they have come up largely empty-handed.

Earlier studies tried to reprogram skin cells back into a pluripotent, stem cell-like state in order to then grow liver cells, explained Dr. Ding, one of the papers senior authors, who is also a professor of pharmaceutical chemistry at UCSF, with which Gladstone is affiliated. However, generating these so-called induced pluripotent stem cells, or iPS cells, and then transforming them into liver cells wasnt always resulting in complete transformation. So we thought that, rather than taking these skin cells all the way back to a pluripotent, stem cell-like state, perhaps we could take them to an intermediate phase.

This research, which was performed jointly at the Roddenberry Center for Stem Cell Research at Gladstone and the Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, involved using a cocktail of reprogramming genes and chemical compounds to transform human skin cells into cells that resembled the endoderm. Endoderm cells are cells that eventually mature into many of the bodys major organsincluding the liver.

Instead of taking the skin cells back to the beginning, we took them only part way, creating endoderm-like cells, added Gladstone and CIRM Postdoctoral Scholar Saiyong Zhu, PhD, one of the papers lead authors. This step allowed us to generate a large reservoir of cells that could more readily be coaxed into becoming liver cells.

Next, the researchers discovered a set of genes and compounds that can transform these cells into functioning liver cells. And after just a few weeks, the team began to notice a transformation.

The cells began to take on the shape of liver cells, and even started to perform regular liver-cell functions, said UCSF Postdoctoral Scholar Milad Rezvani, MD, the papers other lead author. They werent fully mature cells yetbut they were on their way.

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Can we cure heart disease using human stem cells? – Video

Posted: February 24, 2014 at 1:46 pm


Can we cure heart disease using human stem cells?
Our lab reprograms patient skin cells into stem cells so that we can study each patient #39;s individual disease. This video is part of a promotion attached to o...

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Medeniyet Konferansn "nsan Kanser Kk Hcreleri (Human Cancer Stem Cells: Fact or Fiction)" – Video

Posted: February 24, 2014 at 1:46 pm


Medeniyet Konferansn "nsan Kanser Kk Hcreleri (Human Cancer Stem Cells: Fact or Fiction)"
12 ubat 2014 tarihinde niversitemiz Gztepe-Kuzey Yerlekesinde gerekleen konferansta Dr. James A. Radosevich #39;in, "nsan Kanser Kk Hcreleri (Human Canc...

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Medeniyet Konferansn "nsan Kanser Kk Hcreleri (Human Cancer Stem Cells: Fact or Fiction)" - Video

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STAP stem cell doubts keep proliferating

Posted: February 24, 2014 at 1:46 pm

Doubts keep growing about the stunning discovery that super stem cells could be created merely by placing white blood cells from young mice in acid or otherwise stressing them, says Paul Knoepfler, a stem cell researcher at UC Davis.

Among other inconsistencies, Knoepfler referred to several unexplained anomalies in images of these STAP cells in two papers, published by the prestigious journal Nature on Jan. 29. One image appears to suggest signs that virtually all cells treated with an acid bath were being reprogrammed, a result that would be extraordinary. Stem cell reprogramming to date has been inefficient, with a low percentage of treated cells being reprogrammed.

"The more I look at these two STAP papers, the more concerned I get ... The bottom line for me now is that some level a part of me still clings to a tiny and receding hope this has all been overblown due to simple misunderstandings, but that seems increasingly unlikely," Knoepfler wrote Sunday on his blog, IPS Cell.

This undated image made available by the journal Nature shows a mouse embryo formed with specially-treated cells from a newborn mouse that had been transformed into stem cells. Researchers in Boston and Japan say they created stem cells from various tissues of newborn mice. If the same technique works for humans, it may provide a new way to grow tissue for treating illnesses like diabetes and Parkinson's disease. The report was published online on Wednesday, Jan. 29, 2014 in the journal Nature. (AP Photo/RIKEN Center for Developmental Biology, Haruko Obokata)

Nature is conducting its own investigation, Knoepfler noted. But in addition, the journal should release "unmodified, original versions" of the images and data in the papers, Knoepfler wrote.

The images contained "minor errors" that didn't change the basic findings, said Charles Vacanti, a Harvard University professor who is part of the scientific team reporting the discovery, according to a Feb. 22 article in a Japanese newspaper, the Asahi Shimbun.

Controversy is normal for any major scientific advance. Skeptics must be converted, and the only way to do that is to show the data. The 1997 announcement of the first mammalian clone, Dolly the sheep, was greeted with considerable doubt because it was believed that genetic imprinting made such cloning impossible. But others were eventually able to confirm the finding.

In this case, doubters say such an apparently easy method of reprogramming cells would generate pluripotent stem cells far too easily, because stress is common in animals. Such stem cells are known to cause tumors, so evolution should have selected against such a response.

Nature's own role has been criticized. The journal was taken to task for its handling of online journalism Feb. 20 by another stem cell blogger, Alexey Bersenev. He chided Nature for not linking to sources.

"In scientific journalism, every claim must be linked to appropriate original source," Berseney wrote. "Nature consistently refuses to acknowledge bloggers, online discussions and other web resources with valid credible information. This is not acceptable for sci journalism."

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