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Stem cells from fatty tissue show potential for bone repair

Posted: January 16, 2014 at 6:52 pm

BRUSSELS - Belgian medical researchers have succeeded in repairing bones using stem cells from fatty tissue, with a new technique they believe could become a benchmark for treating a range of bone disorders.

The team at the Saint Luc university clinic hospital in Brussels have treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair, and a spin-off is seeking investors to commercialise the discovery.

Doctors have for years harvested stem cells from bone marrow at the top of the pelvis and injected them back into the body to repair bone.

The ground-breaking technique of Saint Luc's centre for tissue and cellular therapy is to remove a sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.

The stem cells are then isolated and used to grow bone in the laboratory. Unlike some technologies, they are also not attached to a solid and separate 'scaffold'.

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Stem cells from fatty tissue show potential for bone repair

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Belgian researchers use groundbreaking surgery to repair bones

Posted: January 16, 2014 at 6:52 pm

Belgian medical researchers have succeeded in repairing bones using stem cells from fatty tissue, with a new technique they believe could become a benchmark for treating a range of bone disorders.

The team at the Saint Luc university clinic hospital in Brussels have treated 11 patients, eight of them children, with fractures or bone defects that their bodies could not repair, and a spin-off is seeking investors to commercialize the discovery.

Doctors have for years harvested stem cells from bone marrow at the top of the pelvis and injected them back into the body to repair bone.

The ground-breaking technique of Saint Luc's centre for tissue and cellular therapy is to remove a sugar cube sized piece of fatty tissue from the patient, a less invasive process than pushing a needle into the pelvis and with a stem cell concentration they say is some 500 times higher.

The stem cells are then isolated and used to grow bone in the laboratory. Unlike some technologies, they are also not attached to a solid and separate 'scaffold'.

"Normally you transplant only cells and you cross your fingers that it functions," the centre's coordinator Denis Dufrane told Reuters television.

His work has been published in Biomaterials journal and was presented at an annual meeting of the International Federation for Adipose Therapeutics and Science (IFATS) in New York in November.

BONE FORMATION

"It is complete bone tissue that we recreate in the bottle and therefore when we do transplants in a bone defect or a bone hole...you have a higher chance of bone formation."

The new material in a lab dish resembles more plasticine than bone, but can be molded to fill a fracture, rather like a dentist's filling in a tooth, hardening in the body.

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Quitting top medical researcher lambasted by authorities

Posted: January 16, 2014 at 6:52 pm

Both the Catalan and central governments have vigorously defended their commitment to the Barcelona Regenerative Medicine Center (CMRB) in the wake of the decision of its director, Juan Carlos Izpisa, to resign.

Izpisa, one of the worlds pre-eminent stem cell researchers, handed in his notice due to government cutbacks in the sciences - the CMRB has lost 16.8 percent of its budget in the last four years. But the Catalonia regional economy chief, Andreu Mas-Colell, told EL PAS that the budget, which is 1.7 million euros annually, will be maintained in 2014 and for the foreseeable future.

Both administrations coincided in accusing Izpisa of lacking dedication to the CMRB in favor of his post at the Salk Institute in California, where all the researchers patents are held.

Government lawyers have been mobilized to examine the intellectual property of the CMRB. Izpisa intends to take 18 of the 21 projects running at the CMRB with him to California, as he considers them his own ideas and initiatives. The administrations will play all their legal cards to prevent this emptying of the Barcelona center, which will, in any case, remain open.

Mas-Colell, who was one of the prime movers in setting up the CMRB, admitted that Izpisa was a great scientist and a key figure in the beginnings of regenerative medicine in Spain. But he underlined two reasons that led the board to withdraw its support. It is not quite correct to say that Spain has lost a great scientist, because the truth is he wasnt in Spain very much; Izipisa first link was with the Salk and the Barcelona center was a research group linked to the Salk.

In the current circumstances a research center in Spain requires a commitment of 100 percent from the director, with both feet rooted in the center, he continued.

The board has chosen ngel Raya, a former postdoctoral researcher for Izpisa, to replace the outgoing director. Raya is a notable researcher in the field [and] he is going to fulfill the condition we require, Mas-Colell said.

The second issue concerns the intellectual property rights relating to the investigations. The mere fact that Izipisa is going to take 18 of the 21 research projects at the CMRB reveals what I said before: that this was not a strong center for Spanish science.

Regarding the patents, Izipisa said: They insinuated that I was benefiting the Salk, but it was more like the other way around, since the Salk had to do all the administration work and pay for the management and the application for the patents, and even like that it shares them with the CMRB in proportion to the scientific contribution of each center. So where is the benefit for the Salk?

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Quitting top medical researcher lambasted by authorities

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Gene therapy improves vision for some with rare disease

Posted: January 16, 2014 at 6:50 pm

Two adults with a rare disease that causes gradual loss of eyesight had their vision improved after being treated with a new gene therapy, according to preliminary results from a new study.

The study involved six patients ages 35 to 63 with choroideremia, an inherited condition with no cure that causes vision problems early in life, and eventually leads to blindness. Patients have a mutation in a gene called CHM, which causes light-sensitive cells in the eye to slowly stop working.

The goal behind the new gene therapy is to use a safe virus to deliver a working copy of the gene to the right part of the eye to prevent the cells from degenerating. [7 Diseases You Can Learn About From a Genetic Test]

The new study was an early test of the therapy in which the researchers aimed to carry out the treatment without causing damage to the eye. (Patients must have an eye surgery so that the virus can be injected under the retina with a fine needle).

The result showed that the treatment did not cause harm, and in fact, improved vision in a few of the patients.

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Six months after the treatment, four patients recovered the visual acuity (clearness or acuteness of vision) that they had before the surgery, and developed increased sensitivity to light. And two patients had improvements in vision: They were able to read two to four more lines on a sight chart.

"We did not expect to see such dramatic improvements in visual acuity," study researcher Robert MacLaren, of the Nuffield Laboratory of Ophthalmology at the University of Oxford in the U.K., said in a statement. It is still too early to know if the improvements will last, but they have so far been maintained for as long as two years, MacLaren said.

The study is the first to test gene therapy in patients before they'd experienced significant thinning of the retinal cells, MacLaren said.

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23. Stem Cells – Video

Posted: January 16, 2014 at 9:42 am


23. Stem Cells
MIT 7.013 Introductory Biology, Spring 2011 View the complete course: http://ocw.mit.edu/7-013S11 Instructor: Hazel Sive Professor Sive discusses cell fate a...

By: MIT

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23. Stem Cells - Video

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Annamaria Mocciaro on future research avenues for stem cell research – Video

Posted: January 16, 2014 at 9:42 am


Annamaria Mocciaro on future research avenues for stem cell research
This interview with Annamaria Mocciaro on the Future of stem cell research is part of the Futurium Talking Futures interview series. More information is avai...

By: DigitalFutures2050

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From stem cells to a possible treatment for Graft-versus-host disease – Video

Posted: January 15, 2014 at 5:40 pm


From stem cells to a possible treatment for Graft-versus-host disease
Xellbiogene #39;s laboratories will test a new pathway for treating Graft-versus-host disease.

By: Xellbiogene

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From stem cells to a possible treatment for Graft-versus-host disease - Video

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Fat stem cells regenerate cartilage in osteoarthritis – Video

Posted: January 15, 2014 at 5:40 pm


Fat stem cells regenerate cartilage in osteoarthritis
http://www.stemcellsarthritistreatment.com http://www.arthritistreatmentcenter.com Dr. Bui Hong Thien Khanh, head of orthopedics at the Ho Chi Minh City Medi...

By: Nathan Wei

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Fat stem cells regenerate cartilage in osteoarthritis - Video

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HealthWACH – Banking baby’s stem cells – Video

Posted: January 15, 2014 at 5:40 pm


HealthWACH - Banking baby #39;s stem cells
For the latest news weather and sports visit: http://www.wach.com Like WACH Fox on Facebook: http://www.facebook.com/wachfox Follow WACH Fox on Twitter: http...

By: WACH FOX

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HealthWACH - Banking baby's stem cells - Video

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ISSCR Board of Directors Discusses Membership – Video

Posted: January 15, 2014 at 5:40 pm


ISSCR Board of Directors Discusses Membership
Board members discuss what ISSCR membership and their visions for the future.

By: International Society for Stem Cell Research (ISSCR)

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ISSCR Board of Directors Discusses Membership - Video

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