Posted: December 22, 2013 at 11:42 pm
10. Treat Cerebral Palsy and Epilepsy with Stem Cells (after)
Cerebral palsy is a non-progressive disease, that is, it will be steady as the growth of children. However, epilepsy is a progressive disease. It will be wor...
By: Cells Center China
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10. Treat Cerebral Palsy and Epilepsy with Stem Cells (after) - Video
Posted: December 22, 2013 at 11:42 pm
The Role of Mesenchymal Stem Cells in treatment of Transverse Myelitis
Barbara Krynska, MS, PhD | Shriners Hospitals Pediatric Research Center and Temple University 2013 Rare Neuro-Immunologic Disorders Symposium Repair and Recovery, Today and in the Future...
By: transversemyelitis
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The Role of Mesenchymal Stem Cells in treatment of Transverse Myelitis - Video
Posted: December 22, 2013 at 7:45 pm
Heart disease: Progress toward stem cell therapies
Join us for this live Google Hangout and learn about recent progress in developing stem cell therapies for heart disease. Hear from stem cell clinical trial ...
By: California Institute for Regenerative Medicine
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Heart disease: Progress toward stem cell therapies - Video
Posted: December 22, 2013 at 7:41 pm
Los Angeles, Dec 21 : Researchers at UCLA's (University of California, Los Angeles') Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during their dormant phase an understanding that could be exploited for better cancer-prevention strategies.
The study, which was led by UCLA postdoctoral fellow Andrew White and William Lowry, an associate professor of molecular, cell and developmental biology who holds the Maria Rowena Ross Term Chair in Cell Biology in the UCLA College of Letters and Science, was published online Dec. 15 in the journal Nature Cell Biology.
Hair follicle stem cells, the tissue-specific adult stem cells that generate the hair follicles, are also the cells of origin for cutaneous squamous cell carcinoma, a common skin cancer. These stem cells cycle between periods of activation (during which they can grow) and quiescence (when they remain dormant).
Using mouse models, White and Lowry applied known cancer-causing genes to hair follicle stem cells and found that during their dormant phase, the cells could not be made to initiate skin cancer. Once they were in their active period, however, they began growing cancer.
"We found that this tumor suppression via adult stem cell quiescence was mediated by PTEN, a gene important in regulating the cell's response to signaling pathways," White said.
"Therefore, stem cell quiescence is a novel form of tumor suppression in hair follicle stem cells, and PTEN must be present for the suppression to work."
Understanding cancer suppression through quiescence could better inform preventative strategies for certain patients, such as organ transplant recipients, who are particularly susceptible to squamous cell carcinoma, and for those taking the drug vemurafenib for melanoma, another type of skin cancer.
The study also may reveal parallels between squamous cell carcinoma and other cancers in which stem cells have a quiescent phase.
The research was supported by the California Institute of Regenerative Medicine, the University of California Cancer Research Coordinating Committee and the National Institutes of Health.
--IBNS (Posted on 21-12-2013)
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Adult stem cells suppress cancer while dormant
Posted: December 21, 2013 at 7:46 pm
From Embryo to Brain Cell: Stem Cells go to School
What are embryonic stem cells? How do scientists grow them in the laboratory, and transform them into different types of cell? What is needed to turn them in...
By: EuroStemCell
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From Embryo to Brain Cell: Stem Cells go to School - Video
Posted: December 21, 2013 at 7:46 pm
10. Treat Cerebral Palsy and Epilepsy with Stem Cells (before)
Cerebral palsy is a non-progressive disease, that is, it will be steady as the growth of children. However, epilepsy is a progressive disease. It will be wor...
By: Cells Center China
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10. Treat Cerebral Palsy and Epilepsy with Stem Cells (before) - Video
Posted: December 21, 2013 at 7:46 pm
Speakiing better and feeling stronger since stem cells
Just proving to myself I am speaking better lol.
By: Jayne Thomas
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Speakiing better and feeling stronger since stem cells - Video
Posted: December 21, 2013 at 7:46 pm
2013 MGOCSM Thanksgiving Conference - Ethical Issues - Homosexuality, Abortion, Stem-Cell Research
2013 MGOCSM Thanksgiving Conference - Session 2. The speaker is Fr. Andrew Stephen Damick Topic: Ethical Issues - Homosexuality, Abortion, Stem-Cell Research...
By: NE Diocese MOSC
Posted: December 21, 2013 at 9:41 am
(PRWEB) December 21, 2013
Stem cell therapy has a tremendous potential to cure various illnesses and injuries. Recent news items have highlighted possibilities that it could treat damaged spinal cords or revitalize hip joints. Scientists are working on stem cell remedies for dementia, heart disease and diabetes. Doctors in some countries have begun using this therapy to grow replacement body tissue and treat leukemia.
However, stem cell treatments remain controversial. Some people object to them on ethical or religious grounds. Others express concern about the safety of these newfound cures. Animal testing has revealed that minor mistakes can result in impurities that cause cells to produce tumors and other ill effects. Some patients have died after receiving experimental therapies that weren't adequately tested.
The producers of the "Leading Edge" TV series plan to release a new segment that examines this fascinating yet contentious health topic. Presenter Jimmy Johnson will offer an update on important facts and recent developments in the world of stem cell research. Viewers can benefit from the program's concise and unbiased perspective on an issue that many people have yet to learn about.
"Leading Edge" is independently distributed to local public TV broadcasters across the U.S. The national Public Broadcasting Service does not act as its distributor. To learn more about this informational series, please browse http://www.leadingedgeseries.com or send an email message to the program's producers. They can be reached at info(at)leadingedgeseries(dot)com.
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"Leading Edge" Set to Produce New Content Featuring Stem Cell Therapy, with Host Jimmy Johnson
Posted: December 21, 2013 at 9:41 am
Florida Hospital Pepin Heart Institute is First in West & Central Florida to Perform a Groundbreaking Stem Cell Clinical Trial for Heart Failure Patients
The first patient has been treated as part of The ATHENA Trial, which derives stem cells from the patientsown adipose (fat) tissue and injects extracted cells into damaged parts of the heart.
TAMPA, Florida (December 20, 2013) Florida Hospital Pepin Heart Institute and Dr. Kiran C. Patel Research Institute announced the first patient, a 59 year old Clearwater man, has been treated as part of the ATHENA clinical trial. The trial, sponsored by San Diego-based Cytori Therapeutics, derives stem cells from the patients own fat tissue and injects extracted cells into damaged parts of the heart. The ATHENA trial is a treatment for chronic heart failure due to coronary heart disease. Dr. Charles Lambert, Medical Director of Florida Hospital Pepin Heart Institute, is leading the way for the first U.S. FDA approved clinical trial using adipose-derived regenerative cells, known as ADRCs, in chronic heart failure patients. I am pleased to report that all procedures went well. The patient is doing well, he was released and is recovering at home. We look forward to following his progress over the coming months, said Dr. Charles Lambert. Heart failure (HF) can occur when the muscles of the heart become weakened and cannot pump blood sufficiently throughout the body. The injury is most often caused by inadequate blood flow to the heart resulting from chronic or acute cardiovascular disease, including heart attacks. The ATHENA clinical trial procedure is a three step process. First, the trial involves the collection of fat from the patients body by liposuction. Then the fat sample is filtered through a machine that extracts out the stem cells. Finally, the stem cells are injected into the damaged part of the patients heart. During this first case at Florida Hospital Pepin Heart Institute, Dr. Paul Smith performed the liposuction to obtain the fat sample, a team at the Dr. Kiran C. Patel Research Institute isolated stem cells from the fat sample and then Dr. Charles Lambert performed the cell therapy by direct injection into the patients heart. Pepin Heart and Dr. Kiran C. Patel Research Institute is exploring and conducting leading-edge research to develop break-through treatments long before they are even available in other facilities. Stem cells have the unique ability to develop into many different cell types, and in many tissues serve as an internal repair system, dividing essentially without limit to replenish other cells, said Dr. Lambert.
The Pepin Heart Institute has a history of cardiovascular stem cell research as part of the NIH sponsored Cardiac Cell Therapy Research Network (CCTRN) as well as other active cell therapy trials. The trial is a double blind, randomized, placebo controlled study designed to study the use of a patients own Adipose-Derived Regenerative Cells (ADRCs) to treat chronic heart failure from coronary heart disease in patients who are on maximal therapy and still have heart failure symptoms. All trial participants undergo a minor liposuction procedure to remove fat (adipose) tissue. Following the liposuction, trial participants may have their tissue processed with Cytoris proprietary Celution System to separate and concentrate cells, and prepare them for therapeutic use. Trial participants will then have either their own cells or a placebo injected back into their damaged heart tissue. To test whether ADRCs will improve heart function, several measurements will be made, including peak oxygen consumption (VO2max), which measures how much physical exercise (gentle walking on a treadmill) a patient can perform, blood flow to the heart (perfusion), the amount of blood in the left ventricle at the end of contraction and relaxation (end-systolic and end-diastolic volumes), and the fraction of blood that is pumped during each contraction (ejection fraction). After the injection procedure, patients are seen in the clinic for follow-up visits over the first 12 months; they are then contacted by phone once a year for up to five years after the procedure.
There are approximately 5.1 million Americans currently living with heart failure, according to the American Heart Association. Chronic heart failure due to coronary heart disease is a severe, debilitating condition caused by restriction of blood flow to the heart muscle, reducing the hearts oxygen supply and limiting its pumping function. Individuals interested in participating in the ATHENA clinical research trial or learning more can visit http://www.theathenatrial.com or call Brian Nordgren, Florida Hospital Pepin Heart Institute Physician Assistant & Stem Cell Program Lead at (813) 615-7527.
About Florida Hospital Tampa Florida Hospital Tampa is a not-for-profit 475-bed tertiary hospital specializing in cardiovascular medicine, neuroscience, orthopaedics, womens services, pediatrics, oncology, endocrinology, bariatrics, wound healing, sleep medicine and general surgery including minimally invasive and robotic-assisted procedures. Also located at Florida Hospital Tampa is the renowned Florida Hospital Pepin Heart Institute, a recognized leader in cardiovascular disease prevention, diagnosis, treatment and leading-edge research. Part of the Adventist Health System, Florida Hospital is a leading health network comprised of 22 hospitals throughout the state. For more information, visit http://www.FHTampa.org.
About Florida Hospital Pepin Heart Institute and Dr. Kiran C. Patel Research Institute Florida Hospital Pepin Heart Institute is a free-standing cardiovascular institute providing comprehensive cardiovascular care with over 76,000 angioplasty procedures and 11,000 open-heart surgeries in the Tampa Bay region. Leading the way with the first accredited chest pain emergency room in Tampa Bay, the institute is among an elite few in the state of Florida chosen to perform the ground breaking Transcatheter Aortic Valve Replacement (TAVR) procedure. It is also a HeartCaring designated provider and a Larry King Cardiac Foundation Hospital. Florida Hospital Pepin Heart Institute and the Dr. Kiran C. Patel Research Institute, affiliated with the University of South Florida (USF), are exploring and conducting leading-edge research to develop break-through treatments long before they are available in most other hospitals. To learn more, visit http://www.FHPepin.org.
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Groundbreaking Stem Cell Clinical Trial
