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Maya Varma – High School Stem Cell Research Intern – Summer 2013, Video Project 2 – Video

Posted: July 29, 2013 at 11:42 am


Maya Varma - High School Stem Cell Research Intern - Summer 2013, Video Project 2
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Maya Varma is ...

By: California Institute for Regenerative Medicine

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Maya Varma - High School Stem Cell Research Intern - Summer 2013, Video Project 2 - Video

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Alfonso Barraza – High School Stem Cell Research Intern – Summer 2013 – Video

Posted: July 29, 2013 at 11:42 am


Alfonso Barraza - High School Stem Cell Research Intern - Summer 2013
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Alfonso Barraz...

By: California Institute for Regenerative Medicine

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Alfonso Barraza - High School Stem Cell Research Intern - Summer 2013 - Video

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Hamburger made of test tube-grown beef from stem cells of slaughtered cow to be cooked and eaten this week

Posted: July 28, 2013 at 7:43 pm

The artificial burger will be cooked and served for the first time this week It cost in the region of 250,000 to produce the prototype The 5oz beef burger is grown from the stem cells of one cow Creator Professor Mark Post believes the development could help solve problems in the meat industry

By Jaymi Mccann and Sophie Borland

PUBLISHED: 04:44 EST, 28 July 2013 | UPDATED: 18:38 EST, 28 July 2013

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The worlds first test-tube burger will be served in London next week. It is made from meat grown in a laboratory, rather than cattle raised in pastures.

And its developers hope it will show how the soaring global demand for protein can be met without the need for vast herds of cattle.

The 5oz Frankenburger, which cost 250,000 to produce, is made from 3,000 tiny strips of meat grown from the stem cells of a cow.

The raw meat is said to be grey with a slippery texture similar to squid or scallop.

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Hamburger made of test tube-grown beef from stem cells of slaughtered cow to be cooked and eaten this week

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Human stem cells help regenerate liver function in mice

Posted: July 28, 2013 at 7:43 pm

Washington, July 28 (ANI): Researchers transplanted derived functional hepatocytes from human stem cells into mice suffering from acute liver injury, and found that these liver cells functioned normally and raised survival of the treated animals.

Massoud Vosough and co-authors demonstrate a large-scale, integrated manufacturing strategy for generating functional hepatocytes in a single suspension culture grown in a scalable stirred bioreactor.

In the article 'Generation of Functional Hepatocyte-Like Cells from Human Pluripotent Stem Cells in a Scalable Suspension Culture' the authors describe the method used for scale-up, differentiation of the pluripotent stem cells into liver cells, and characterization and purification of the hepatocytes based on their physiological properties and the expression of liver cell biomarkers.

David C. Hay, MRC Centre for Regenerative Medicine, University of Edinburgh, U.K., comments on the importance of Vosough et al.'s contribution to the scientific literature in his editorial in Stem Cells and Development entitled 'Rapid and Scalable Human Stem Cell Differentiation: Now in 3D.'

The researchers 'developed a system for mass manufacture of stem cell derived hepatocytes in numbers that would be useful for clinical application,' creating possibilities for future 'immune matched cell based therapies,' Hays said.

Such approaches could be used to correct mutated genes in stem cell populations prior to differentiation and transplantation, he adds.

The findings have been published in Stem Cells and Development. (ANI)

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Human stem cells help regenerate liver function in mice

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Bioethicist: Failed search for controversial form of stem cells shows danger of mixing science, religion

Posted: July 28, 2013 at 7:43 pm

Stem cells

Arthur Caplan, Ph.D NBC News contributor

5 hours ago

What should we think when a scientist claims to have found a cell in the human body with miraculous powers that no one before has ever seen and almost no one else can even find trying to follow his directions of where to look?

The small number of scientific proponents of the miraculous healing powers of a controversial form of stem cells called VSELSvery small embryonic-like stem cells -- are facing this very question. The usual answer is that, at best, the claim must be the product of wishful thinking, or at worst, fraud.

A just published study by the distinguished stem cell biologist Irving Weissman of Stanford Universitys School of Medicine says he and his team could not find VSELS or corroborate their alleged regenerative power. The Catholic Church, because of its opposition to embryo destruction to obtain stem cells for research, gave its blessings and money to VSELS therapy so it also now finds itself up to its miters in controversy.

A few years ago in early November 2011, I was lucky enough to be asked to attend a meeting on stem cell research at the Vatican. Key officials there had decided that worldwide battles over the ethics of using of embryonic stem cells merited a gathering of scientists and prominent Catholic theologians. To no ones surprise including mine, the meeting was designed as a celebration of the power of adult stem cellsnaturally occurring cells in your body that can regenerate damaged tissue or grow new cells including bone marrow, hair follicle cells and the lining of the gut and liver cells. The Vatican wanted these and only these kinds of cells to be used to cure now intractable diseases such as spinal cord injury, diabetes and heart disease. Those doctors and scientists who favored studying cells taken from human embryos, which meant their destruction, which also can regenerate many different kinds of cells, got little airtime and no ethical traction.

One of the strangest moments at the conference came when Polish-born researcher Mariusz Z. Ratajczak, now on the faculty at the University of Louisville, stood up and told the enthralled bishops, priests, monsignors, cardinals, theologians and the few other odd ducks like me that he had found very tiny cells residing in adult cells that behaved just like embryos. Ratajczak said they could develop into all manner of other cells, thereby acting as natural repair kits, given the right conditions and genetic tweaking.

The theologians were delighted. They were so excited that they took the unprecedented step of investing the churchs money in a company, Neostem, to help develop Ratajczaks discovery. His VSELS would provide an ethical way to use stem cells to cure disease while getting the Church out of a horrible bindcondemning embryo destruction for obtaining stem cells while so many worldwide suffered premature death and serious disability.

Weissman thinks VSELS are nothing more than cell debris and fragments from dying cells. He does not believe "that VSELs have the potentials claimed, he wrote in the study, and doubts that these cells have potential for clinical application in humans. Weissman study is now the fourth to fail to find the miracle VSELS or to be able to show any evidence of their regenerative healing power.

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Bioethicist: Failed search for controversial form of stem cells shows danger of mixing science, religion

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Lesly Ann Llarena – High School Stem Cell Research Intern – Summer 2013 – Video

Posted: July 28, 2013 at 7:41 am


Lesly Ann Llarena - High School Stem Cell Research Intern - Summer 2013
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Lesly Ann Llar...

By: California Institute for Regenerative Medicine

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Lesly Ann Llarena - High School Stem Cell Research Intern - Summer 2013 - Video

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Li Juan Chen – High School Stem Cell Research Intern – Summer 2013 – Video

Posted: July 28, 2013 at 7:41 am


Li Juan Chen - High School Stem Cell Research Intern - Summer 2013
Visit our Through Their Lens page for photos and more videos from students and grantees: http://www.cirm.ca.gov/instagram-CIRMStemCellLab-feed Li Juan Chen i...

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Li Juan Chen - High School Stem Cell Research Intern - Summer 2013 - Video

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California Stem Cell Official Duane Roth in Improving Condition

Posted: July 28, 2013 at 3:04 am

Duane Roth, the co-vice chairman of the
California stem cell agency, is improving after he was hospitalized
for treatment of a serious brain injury sustained in a bicycle accident Sunday in
the mountains east of San Diego.
According to a report on Xconomy.com,
Roth's brother, Ted, said yesterday, 

“Were certainly moving in the
right direction. We're now looking at the recovery phase.”

The article by Bruce Bigelow said Roth
has passed through the most critical period following surgery at the
UC San Diego hospital.
Roth, the 63-year-old CEO of the San
Diego technology organization, Connect, is in serious condition in a
medically induced coma.
The governing board of the California
stem cell agency yesterday took special note of Roth at its meeting and sent its best wishes to him and his family.  

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/nmnYkisG6MU/california-stem-cell-official-duane.html

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Another $23 Million to Recruit Star Stem Cell Scientists to California

Posted: July 28, 2013 at 3:04 am

California's $46 million effort to lure
stem cell research stars to the Golden State was expanded today by
another $23 million.
Directors of the stem cell agency
approved the funds on a 14-4-1 vote. CIRM directors Jeff Sheehy and
Francisco Prieto were among those opposing the move. Prieto declared,

“We are coming up against finite resources. We have better ways to spend
our money."

 Sheehy said that CIRM is contributing to inflation in stem cell science with its lucrative recruitment grants. 

Those supporting the expansion said that the grants have had a great impact on the field, not only bringing in individual scientists, but accompanying researchers in their labs along with grants from other sources.
The additional funds will go to
institutions that have not already benefited from one of the earlier
grants in the program. Up to four awards are expected to be made.
The CIRM staff proposal on the plan
said,

“A number of California institutions
have not yet been able to secure a confirmed Research Leadership
award but would benefit greatly from the recruitment of emerging or
established leaders in stem cell biology. Participation in the CIRM
program could bring additional, exceptional researchers to
California, strengthen and synergize with other efforts to build up
local sustained research communities in stem cell biology and
medicine and provide ongoing leadership at the cutting edge of
California regenerative medicine.”

All of the California institutions
involved with the winning researchers have representatives on the
governing board of the stem cell agency. They are not allowed, however, to vote
on grants to their institutions or researchers -- only on proposals such as today's $23 expansion.
Applications are due in January with
final approval scheduled for next May. The program is not open to
businesses.

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California Stem Cell Agency Launches $70 Million Alpha Stem Cell Clinic Project

Posted: July 28, 2013 at 3:04 am

The California stem cell agency today approved
a $70 million plan to create a network of “Alpha” stem cell
clinics that is aimed at making the Golden State one of the leading
purveyors and developers of stem cell therapies in the world.

The 29-member governing board of the California
Institute for Regenerative Medicine (CIRM)
adopted the plan on a 19-1 vote. The negative vote came from Joan Samuelson, who questioned
whether the plan was premature and whether existing scientific research justified development of the clinics. 
Sherry Lansing, a patient advocate board member and
former head of a Hollywood studio, said the proposal is “one of the
most exciting proposals that we have ever had in front of us.” She
said it was the “beginning of this dream coming true.”
Under the far-reaching proposal, which
CIRM President Alan Trounson has been promoting for two years, the
agency will finance five stem cell clinics at established
institutions in California with grants of up to $11 million. Another
$15 million will be allotted for a stem cell information and
coordination center. Major matching contributions will be expected
from award winners over the five-year terms of the grants.
The effort is aimed at drawing in
clinical trials and patients from the around the world and creating a
central bank of knowledge, know-how and regulatory expertise. It
will also guide efforts to build profits into stem cell therapies
and to develop strategies to attract investors and philanthropists.
(For more information on the plan, see here, here, here, here and
here.)
Trounson said in a statement,

“These clinics have the potential to
revolutionize how we deliver stem cell therapies to patients. Stem
cell therapies are a completely new way of treating diseases and
disorders so we need a completely new way of delivering those in a
safe and effective manner. These clinics will help us do just that
and the clinical trials carried out in this network will fulfill the
agency’s promise of bringing new therapies to patients who need
them.” 

The journal Nature Medicine has
reported that the Alpha clinics would be the first-ever “clinical
trials network focused around a broad therapeutic platform.”
The CIRM board heard no negative
comment on the plan other than the remarks by Samuelson. . However,
not everyone sees a need for it. Mahendra Rao, director of the Center
for Regenerative Medicine
 at the National Institutes of
Health(NIH)
, says its surveys of researchers have not shown a demand
for such centers. In May, a researcher at institution that likely
would be an applicant filed a blistering, anonymous comment on the
California Stem Cell Report, describing it as a "boondoggle" and "irresponsible." The scientist said,

“Another boondoggle for some medical
schools but made to order for private operators like for-profit
cancer, dialysis, and laser eye specialty clinics that do one
procedure.  I can see each of the medical schools gifted with
one as they each were gifted with about 25 million dollars for stem
cell institute buildings.”

The researcher continued,

“The NIH at various times has tried
to organize clinical trials groups with infrastructure, like quick
reaction forces, ready to gear up for a new trial at the drop of a
hat. They mainly did nothing but suck money, kept staff employed,
because there are generally few drugs ready for early human trials
and each treatment that is brought along requires a unique contract,
ethics reviews, and different facilities, equipment and staff than
planned for.  The latest incarnation are CTSAs or CTSIs,
clinical and translational science centers funded by the federal NIH
that most if not all California medical schools already have.”

The RFA for the proposal is expected to
go out in October and approval of funding coming one year from now. Here is the link to today's CIRM press release on the plan. 

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/EBbBzLL9dQQ/california-stem-cell-launches-70.html

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