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KS3:4 Science – Stem Cell Research- The Issue – Video

Posted: February 25, 2013 at 12:41 am


KS3:4 Science - Stem Cell Research- The Issue
Crown Copyright. Provided by Arts College Limited. artsuk.org Further resources available on http Licensed to Arts College Limited. Licence information available at: artsuk.org Embryonic stem cells and the future of Parkinson #39;s Disease. Stephen Cuff is only 39, but he suffers from Parkinson #39;s Disease and it has turned his life upside down. He can no longer look after his two children and basic day-to-day activities like shaving, takes him a long time. Conventional drugs have not been successful for Stephen, leaving him no option but to undergo brain surgery. Stephen #39;s operation is successful, but it doesn #39;t cure him. One potential future cure is embryonic stem (ES) cell therapy. This is being pioneered by the likes of Professor Ian Wilmut, who became famous when he cloned Dolly the sheep. Professor Wilmut introduces us to the concept of stem cells and the science behind them, whilst presenting his opinion of the technology. Alison Davies, the chair of No Less Human, is a wheelchair user who would refuse ES cell therapy if it were available. She offers a different ethical perspective as to why the use of ES cells should not be permitted. We also hear the differing opinions of leading cell biologists at a recent stem cell conference.

By: ACLChannel0

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KS3:4 Science - Stem Cell Research- The Issue - Video

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California Stem Cell Agency Bonds On Sale in March

Posted: February 24, 2013 at 9:48 pm

Early next month, the state of
California will sell $2.7 billion in bonds, a tiny fraction of which will go
towards the California stem cell agency.

It is all part of an arrangement that
currently involves short-term borrowing as well to keep the cash
pipeline at CIRM properly filled.
To refresh some of you, the agency
subsists off money that the state borrows (bonds) instead of going to
the legislature annually for financial support. While that avoids
competing against school children, the poor, the University of
California, state colleges, parks, highways and other interests
seeking state funding, it also means that the cost of a $20 million
grant is something closer to $40 million because of the interest
expense.
The California Stem Cell Report last
week asked the state treasurer's office about the bond sale March
12-13 and what it means for the stem cell agency. Here is what Tom
Dresslar
, spokesman for the treasurer, replied in an email.

“CIRM’s funding needs now are met
via the issuance of commercial paper (CP).  They’re authorized
a certain amount of CP periodically.  Then we work with them on
a regular basis to issue the commercial paper on an as-needed basis. 
Last fall, they were authorized $160 million of CP.  We will
issue the first $27 million under that authorization (this) week. 
This spring, CIRM is scheduled to receive another $100 million
authorization. The Department of Finance , consulting with CIRM
officials, determined the $100 million would be needed to meet CIRM’s
funding requirements through the end of 2013.

“Now, here’s where it gets a little
complicated.  The state pays down the CP with bond proceeds. 
The March ....bond sale includes $60 million of stem
cell bonds.  Those proceeds won’t provide new money for CIRM,
but will pay down the CP proceeds CIRM already has used.”

Proposition 71, which created the stem
cell agency in 2004, authorized bond sales for stem cell research for
only 10 years. CIRM's financial timekeepers say the clock started
running when the first bonds were sold. The upshot is that the agency
will run out of money for new grants in less than four years.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/GGDUJVY45VQ/california-stem-cell-agency-bonds-on.html

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City of Hope Exec Will Leave California Stem Cell Agency Board

Posted: February 24, 2013 at 3:04 am

Michael Friedman
City of Hope photo
The governing board of the $3 billion
California stem cell agency will lose another one of its veteran
members this year – Michael Friedman, the CEO of the City of Hope
in the Los Angeles area.
He will join Claire Pomeroy in leaving
the board. Pomeroy is resigning as vice chancellor of Human Health
Services at UC Davis this spring to become president of the Lasker Foundation in New York.. Friedman is retiring at the end of this year.
Both have been on the CIRM board since
its first meeting in December 2004. Pomeroy was appointed by the UC
Davis chancellor. Friedman was appointed by the state treasurer.
No names have surfaced concerning
likely successors. However, the UC Davis chancellor is required by
law to appoint an executive officer from the campus. The new dean at
the UCD medical school would seem to be the most likely candidate.
To fill Friedman's seat, Treasurer Bill
Lockyer
must appoint an executive officer from a California research
institute. The tradition on the board has been for particular
institutes to hold particular seats on the board. The major exception
is the Salk Institute, which lost a seat on the board a few years
back.
Both UC Davis and the City of Hope have
benefited enormously from CIRM largess. UC Davis has received $131
million and the City of Hope $51 million. Although Friedman and
Pomeroy have not been allowed to vote on grants to their
institutions, their presence and the presence on the board of other executives
from beneficiary institutions has triggered calls for sweeping changes at the agency.
A blue-ribbon report by the Institute
of Medicine
said “far too many” board members are linked to
institutions that receive money from CIRM. The institute recommended
that a new majority of independent members be created on the board.
According to compilations by the
California Stem Cell Report, about 90 percent of the $1.8 billion the
board has awarded has gone to institutions with ties to past and
present board members. Fifteen of the 29 members of the board, which
has no independent members along the lines suggested by the IOM, are
linked to recipient institutions.
The agency has $700 million remaining
before money for new awards runs out in less than four years.  

Source:
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Monitoring the Cash and IP at the California Stem Cell Agency

Posted: February 24, 2013 at 3:04 am

The $3 billion California stem cell
agency appears unlikely to make any changes in who gets the cash from
any commercial products that its research grants help finance despite
recommendations from the Institute of Medicine(IOM).

The subject will come up next Wednesday
during a meeting of the intellectual property subcommittee of the
governing board of the stem cell agency. Intellectual property (IP) simply
determines ownership rights and the share of any revenue from
therapies that result from research.
CIRM staff has prepared a briefing paper with recommendations for next week's meeting, which has
teleconference locations in La Jolla, Los Angeles, two in Irvine
along with the main site in San Francisco.
The document summarized two key IOM
recommendations in this fashion:

“Because CIRM is a new institution
without a track record to reassure stakeholders, and because its
finite funding timeline means as yet unknown agencies will be
enforcing these policies years down the road, CIRM should “propose
regulations that specify who will have the power and authority to
assert and enforce in the future rights retained by the state” in
CIRM IP, specifically referring to march-in rights, access plans and
revenue sharing....

“Second, as other sources of funding
become more prevalent, the agency should “reconsider whether its
goal of developing cures would be better served by harmonizing CIRM’s
IP policies wherever possible with the more familiar policies of the
BayhDole Act.

Here are the CIRM staff
recommendations.

“CIRM staff has engaged in
preliminary discussions several years ago with other agencies
regarding future enforcement of CIRM’s regulations and agreements.
Staff proposes to restart those discussions and return to the
Subcommittee (or the Board) with a formal proposal to address future
enforcement of CIRM’s IP regulations.”

“In light of the IOM’s own
recognition that it may be premature to assess whether CIRM’s
regulations will act as a deterrence to future investment, the fact
that a number of CIRM’s regulations have been codified in statutes
and CIRM’s positive progress in its industry engagement efforts to
date, although quite early, CIRM staff proposes to continue to
monitor this area and not to pursue any changes at this time.”

The director's subcommittee is unlikely
to diverge significantly from the staff proposal, which was dated
Feb. 14 but not posted on the CIRM website until Feb. 20.   

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/xvosTob7Zo0/monitoring-cash-and-ip-at-california.html

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Half-full, Half-empty Editorial on California Stem Cell Agency

Posted: February 24, 2013 at 3:04 am

The California stem cell agency's
editorial road show paid off a bit again this week with a mildly
approving editorial in the Oakland Tribune.

The Feb.18 piece said that the presence
of Jonathan Thomas, a Los Angeles bond financier, as chairman of the
$3 billion agency has improved things, compared to the reign of Bob
Klein
, who “built a protective shield” around the agency's
governing board and prevented action to deal with obvious
conflict-of-interest problems.
The newspaper also said that “to some
extent” the agency has brought “cutting edge” scientists to the
state and helped boost the stem cell field.
That was the half-full side of the
editorial. The half-empty side included the headline.

“California
must get its stem cell house in order”

The editorial continued:

“...{T)he agency must prove that it
understands how to properly handle the public's money. …. If
the stem cell agency can establish a record as a good steward of
public dollars to finance brilliant science, it can continue to play
a useful role in stimulating and guiding research to bring the
potential cures from stem cell research to fruition.

“If it cannot do that, it will be
just another expensive Tyrannosaurus rex.”

Thomas and company are knocking on
editorial doors around the state in hopes of building support for the
board's modest – some might say inadequate – response to
recommendations for sweeping changes at the agency.  

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/tMt6gs55Yvs/half-full-half-empty-editorial-on.html

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Time For Public Disclosure of Financial Interests of Stem Cell Agency Reviewers

Posted: February 24, 2013 at 3:04 am

Should the scientists who evaluate
and score the applications for $3 billion in taxpayer funds be
required to publicly disclose their financial interests?

No, says the California stem cell
agency, despite concerns by the state auditor and the state's Fair
Political Practices Commission (FPPC)
that date back at least six
years. The agency says that its governing board makes the decisions
on the applications – not the grant reviewers – and that the
members of the board fully disclose their economic interests.
However, last month the agency produced
a document that sheds new light on the issue. The document confirms
that the board rubber-stamps virtually all the reviewers' decisions,
going along with their actions 98 percent of the time. The board
exercised independent judgment on 28 out of 1,355 applications.
Why is this important? Here is what the state auditor said in 2007,

“(T)he FPPC believes that, under
state regulations, working group members (including grant reviewers)
may act as decision makers if they make substantive recommendations
that are, over an extended period, regularly approved without
significant amendment or modification by the committee. Thus, as
decision makers, working group members would need to be subject to
the conflict-of-interest code. This would mean that working groups
would be subject not only to the (public) financial disclosure requirements of
the Political Reform Act but also to the prohibition against a member
participating in a government decision in which that member has a
disqualifying financial interest and may be subject to the penalties
that may be imposed on individuals who violate that act.”

The auditor recommended that the stem
cell agency seek an attorney general's opinion on the matter, a
recommendation the agency agency summarily dismissed seven months later..
Then interim CIRM
President Richard Murphy, a former member of the agency's board and
former president of the Salk Institute, replied to the auditor:

"We have given careful
consideration to your recommendation and have decided it is not
appropriate to implement at this time. In almost three years of
operation and approval of four rounds of grants, the recommendations
of the CIRM working groups have never been routinely and/or regularly
adopted by the ICOC. Until the time that such a pattern is detected,
the question you suggest we raise with the attorney general is
entirely hypothetical, and is therefore not appropriate for
submission. We will, however, continue to monitor approvals for such
a pattern and will reconsider our decision if one emerges."

In the four rounds mentioned in
Murphy's response, 100 percent of reviewer decisions were
rubber-stamped by the board. In the other two rounds, the percentage
was 95 and 96 percent.
Currently, scientific grant reviewers at the stem cell agency, all of whom are from out-of-state, disclose financial and professional conflicts
of interest in private to selected CIRM officials. (See policy here.)
From time to time, grant reviewers are excused from evaluating
specific applications.
The CIRM governing board has resisted
requiring public disclosure of the interests of reviewers. The subject
has come up several times, but board members have been concerned
about losing reviewers who would not be pleased about disclosing
their financial interests.  Nonetheless, disclosure of interests among researchers is becoming routine in scientific research articles. Many universities, including
Stanford, also require public disclosure of financial interests of
their researchers. Stanford says,

“No matter what the circumstances --
if an independent observer might reasonably question whether the
individual's professional actions or decisions are determined by
considerations of personal financial gain, the relationship should be
disclosed to the public during presentations, in publications,
teaching or other public venues.”

The latest version of CIRM's conflict
of interest rules are under review by the FPPC. They do not include
any changes in public disclosure for grant reviewers. In view of the
new information that confirms that reviewers are making 98 percent of
the decisions on who gets the taxpayers' dollars, it would seem that it is long past due for public disclosure of both financial and professional
interests of reviewers. Indeed, given the nature of scientific
research and the tiny size of the stem cell community, disclosure of
professional interests may be more important than financial
disclosures.

"The public trust in what we do is
just essential, and we cannot afford to take any chances with the
integrity of the research process."

Here is the CIRM document concerning
reviewers' decisions and governing board action. The table has not
been posted on the CIRM website, but it was prepared for last month's
meeting dealing with the Institute of Medicine's recommendations for
sweeping changes at the agency, especially related to conflicts of
interest.

Source:
http://feedproxy.google.com/~r/blogspot/uqpFc/~3/oma-MLcANoY/time-for-public-disclosure-of-financial.html

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Experts claim, babies source of stem cells

Posted: February 24, 2013 at 12:57 am

BEAUTY at the expense of babies.

With this, the Philippine Society for Stem Cell Medicine (PSSCM) gave another reason for Filipinos to stop patronizing the emerging stem cell therapy in the country revealing that some of them are actually sourced from human babies.

In a statement, PSSCM Spokesman Dr. Leo Olarte disclosed that it has come to their knowledge that there are a number of cases, where the stem cells used for several anti-aging procedures and other medical treatments are actually acquired from babies, with some even from elective abortion abroad.

With this in mind and realizing that we can consider this as exploitation of other human beings for personal benefit, we ask ourselves if this is an ethical and moral medical procedure, Olarte said.

We cannot stand by and merely watch how they exploit people in poverty just to profit while allowing others who are economically well off to benefit from this, he furthered.

He said the information came after they attended a scientific forum in the United States that tackled the issue of human commoditization for commercial and economic purposes.

The Philippine Medical Association (PMA) noted how human fetus harvesting for stem cell transplant, also known as allogenic sourced-out stem cells, has become prevalent in countries like the Ukraine, Switzerland, Russia, and Malaysia.

Last month, the PSSCM had already raised concerns over the risks of complications, and possibly death, from stem cell treatments.

The PSSCM had said that stem cell patients run the risk of graft-versus-host disease (allogeneic transplant only), stem cell (graft) failure, organ injury, infections, cataracts, infertility, new cancers, and death.

Stem cell therapy is a type of intervention strategy that introduces new adult stem cells into damaged tissue in order to treat disease or injury.

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Experts claim, babies source of stem cells

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PH stem cell society warns: Stem cells in some anti-aging procedures came from aborted babies abroad

Posted: February 24, 2013 at 12:57 am

By: Jet Villa, InterAksyon.com February 24, 2013 9:10 AM

Stem cell tray. AFP/GETTY IMAGES FILE PHOTO

InterAksyon.com The online news portal of TV5

MANILA The stem cells used in some anti-aging medical procedures here were harvested not from recipients themselves or donors but from elective abortion of human babies abroad, the Philippine Society for Stem Cell Medicine (PSSCM) warned.

PSSCM spokesperson Dr. Leo Olarte said that in some procedures, the sources of the stem cells are babies and even the egg cells of women.

This practice poses ethical and moral questions, he said.

With this in mind and realizing that we can consider this as exploitation of other human beings for personal benefit, we ask ourselves if this is an ethical and moral medical procedure, he said.

Olarte said the entry of these stem cells in the country must be stopped.

We cannot stand by and merely watch how they exploit people in poverty just to profit while allowing others who are economically well off to benefit from this, he added.

In countries like the Ukraine, Switzerland, Russia, and even Malaysia, harvesting human fetuses for stem cell transplant has become so prevalent that even normal healthy babies are being used to generate the cells that are supposed to make older people look and feel younger, he said.

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PH stem cell society warns: Stem cells in some anti-aging procedures came from aborted babies abroad

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Authorities Warn Against Anti-Aging Procedures Using Human Stem Cells

Posted: February 24, 2013 at 12:57 am

MANILA, Philippines --- The Philippine Society for Stem Cell Medicine (PSSCM) yesterday warned against anti-aging procedures and medical treatments that use stem cell harvested from human fetuses and even from egg cells of women.

Dr. Leo Olarte, PSSCM spokesperson, released a statement over the weekend to address some "alarming number of cases" in which stem cells used for anti-aging and medical treatments were actually gathered from babies and egg cells.

Olarte said the local medical community was alarmed when he reported what he learned from a recent scientific forum in the United States that centered on the issue of exploitation of humans for "commercial and economic purposes."

The PSSCM official, who is also the vice president of the Philippine Medical Association (PMA), said that in countries like Ukraine, Switzerland, Russia and even Malaysia, harvesting stem cells from human fetuses has become quite common that even normal and healthy babies are being used for harvesting.

This practice is known as allogenic sourced-out stem cells or cells that come from a matched related or unrelated donor.

Olarte called on the Department of Health (DOH) to check whether or not this practice is already prevalent in the country especially hearing reports that a Malaysian pharmaceutical group has already begun offering human-derived allogenic stem cells to several local doctors, including dermatologists and cosmetologists.

The stem cells were said to be sourced from Ukraine and Russia.

"With this in mind and realizing that we can consider this as exploitation of other human beings for personal benefit, we ask ourselves if this is an ethical and moral medical procedure," Olarte said.

"I am also calling on the Catholic Church to unite with us. We must put an end to this once and for all before it overwhelms us. We should prevent the entry of human-derived allogenic stem cells from aborted fetuses which are being exported to the Philippines today," he added.

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Authorities Warn Against Anti-Aging Procedures Using Human Stem Cells

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Stem cells used in some anti-aging procedures here from aborted babies abroad – PSSCM

Posted: February 24, 2013 at 12:57 am

By: Jet Villa, InterAksyon.com February 24, 2013 9:10 AM

Stem cell tray. AFP/GETTY IMAGES FILE PHOTO

InterAksyon.com The online news portal of TV5

MANILA The stem cells used in some anti-aging medical procedures here were harvested not from recipients themselves or donors but from elective abortion of human babies abroad, the Philippine Society for Stem Cell Medicine (PSSCM) warned.

PSSCM spokesperson Dr. Leo Olarte said that in some procedures, the sources of the stem cells are babies and even the egg cells of women.

This practice poses ethical and moral questions, he said.

With this in mind and realizing that we can consider this as exploitation of other human beings for personal benefit, we ask ourselves if this is an ethical and moral medical procedure, he said.

Olarte said the entry of these stem cells in the country must be stopped.

We cannot stand by and merely watch how they exploit people in poverty just to profit while allowing others who are economically well off to benefit from this, he added.

In countries like the Ukraine, Switzerland, Russia, and even Malaysia, harvesting human fetuses for stem cell transplant has become so prevalent that even normal healthy babies are being used to generate the cells that are supposed to make older people look and feel younger, he said.

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Stem cells used in some anti-aging procedures here from aborted babies abroad - PSSCM

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