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Stem Cell Agency Plan Falls Far Short of Solving IOM Concerns

Posted: January 30, 2013 at 2:18 am

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Data From SGEN on Cancer Candidate

Posted: January 30, 2013 at 1:44 am

Seattle Genetics, Inc. (SGEN) recently presented interim results from a phase I study which is evaluating ASG-5ME for the treatment of metastatic pancreatic ductal adenocarcinoma (:PDA).

Seattle Genetics is developing ASG-5ME, an antibody-drug conjugate (ADC) which targets the SLC44A4 antigen, for the treatment of solid tumors. The candidate is being developed in collaboration with Agensys, Inc., an affiliate of Tokyo-based Astellas Pharma Inc. (ALPMY).

The trial is being conducted to evaluate the safety and activity along with identifying the maximum tolerated dose (MTD) of ASG-5ME in patients suffering from metastatic PDA. Approximately 35 patients with metastatic PDA and a median age of 63 were administered doses ranging from 0.3 milligrams per kilogram (mg/kg) to 1.5 mg/kg administered weekly for three of every four weeks. Data from the study, apart from providing preliminary evidence for antitumor activity, revealed that the candidate was well tolerated.

We note that Seattle Genetics is also evaluating ASG-5ME in the prostate and gastric cancer indications. Seattle Genetics focuses on the development and commercialization of monoclonal antibody-based therapies for cancer.

We remind investors that Seattle Genetics leading drug, Adcetris, is currently approved in the US for the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplant (:ASCT) or after failure of at least two prior multi-agent chemotherapy regimens in patients, who are not suitable for ASCT and the treatment of sALCL in treatment-experienced patients. Adcetris is approved in the EU as well.

Seattle Genetics carries a Zacks Rank #3 (Hold). Pharma stocks, which currently appear to be more attractive include Valeant Pharmaceuticals (VRX) and Salix Pharmaceuticals (SLXP). Both companies carry a Zacks Rank #1 (Strong Buy).

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Data From SGEN on Cancer Candidate

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Vichy Expert interview – What is the interest of stem cells ? – Video

Posted: January 29, 2013 at 9:49 pm


Vichy Expert interview - What is the interest of stem cells ?

By: VichyMiddleEast

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Vichy Expert interview - What is the interest of stem cells ? - Video

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Gwyneth Paltrow use stem cells cosmetics 00 – Video

Posted: January 29, 2013 at 9:49 pm


Gwyneth Paltrow use stem cells cosmetics 00
Gwineth Palthrow and Sonya Dakar presenting Apple Stem Cell Cosmetics on Extra TV at CNBC Get yourself the Hollywood Stars facial treatment on http://www.laduchesse.ro and stay in touch with our beauty news on http://www.laduchessecosmetics.com

By: Isabelle d #39;Envie

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Gwyneth Paltrow use stem cells cosmetics 00 - Video

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Blood Stem Cells – immune-mediated keratitis – Video

Posted: January 29, 2013 at 9:49 pm


Blood Stem Cells - immune-mediated keratitis
At present many eye pathologies have the alteration of the eye #39;s privileged immune system in common. The eye #39;s privileged immune system has the objective of protecting the eye from infections, minimizing inflammation and activating a process of complex interrelations, making it complicated ,if not impossible, to fully understand . The more we investigate micro-organisms, innate immunity, adaptive immunity, receptors,substances produced by involved cells, etc..., the more this process #39;s evolution appears to be so structured and interconnected that we have to continually revaluate it. Today #39;s treatment for immunomediate illnesses of the eye is the immunosuppression through drugs such as glucocorticoids, cyclosporine A, tacrolimus, doxycycline , etc.... As an alternative we propose immunoregulation using blood stem cells that know the organism and are able to make decisions, acting by orchestrating the healing of the eye behaving like a small pharmaceutical company that produces the right drug at the right time in these complex interrelations. IMMUNE-MEDIATED KERATITIS Immune-mediated keratitis is a non ulcerative corneal disease characterized by some of the following clinical symptoms: vascularization, edema and inflammatory cell response within the cornea and absence of uveal pathology. In the pathological process there may be temporary painful erosions, but normally the pain is minimal with respect to the dramatic symptoms. This is a pathology with unknown causes but ...

By: Marco Polettini

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Blood Stem Cells - immune-mediated keratitis - Video

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Biotech Showcase 2012_ReNeuron – Video

Posted: January 29, 2013 at 9:49 pm


Biotech Showcase 2012_ReNeuron
ReNeuron is a leading, clinical-stage stem cell business. Our primary objective is the development of novel stem cell therapies targeting areas of significant unmet or poorly met medical need. We have used our unique stem cell technologies to develop cell-based therapies for significant disease conditions where the cells can be readily administered "off-the-shelf" to any eligible patient without the need for additional drug treatments. Our lead therapeutic candidate is our ReN001 stem cell therapy for the treatment of patients left disabled by the effects of a stroke. This treatment is currently in clinical development. We are also developing stem cell therapies for other conditions such as critical limb ischaemia, a serious and common side effect of diabetes, and blindness-causing diseases of the retina. http://www.reneuron.com View ReNeuron #39;s Alliance for Regenerative Medicine member profile at alliancerm.org

By: AllianceRegenMed

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Biotech Showcase 2012_ReNeuron - Video

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Dr Xanya Weiss on Signaling Technology and Stem Cells – Video

Posted: January 29, 2013 at 9:49 pm


Dr Xanya Weiss on Signaling Technology and Stem Cells
Impressive Lecture was offered by Dr Xanya Weiss on Signaling Technology and Stem Cells in ICAD medical conference on Anti-aging Medicine

By: Isabelle Devon

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Dr Xanya Weiss on Signaling Technology and Stem Cells - Video

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Stem Cell Lecture – Video

Posted: January 29, 2013 at 9:49 pm


Stem Cell Lecture
Honors lecture over stem cells and cell differentiation. More like a guide through some cool links than a lecture.

By: MrsShawBiology

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Stem Cell Lecture - Video

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A cardiomyocyte derived from induced pluripotent stem cells.ogv – Video

Posted: January 29, 2013 at 9:49 pm


A cardiomyocyte derived from induced pluripotent stem cells.ogv
Short clip showing a cardiomyocyte (heart muscle cell) derived from induced pluripotent stemcells (iPSCs). Visit http://www.stemcellsfreak.com for more info on iPSCs

By: Nikos Korompos

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A cardiomyocyte derived from induced pluripotent stem cells.ogv - Video

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Mesenchymal stem cells – Video

Posted: January 29, 2013 at 9:49 pm


Mesenchymal stem cells
Just some mesenchymal stem cells, check out http://www.stemcellsfreak.com for more information about them

By: Nikos Korompos

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Mesenchymal stem cells - Video

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