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BHERC Presents Its First Health Matters Film Screening and Panel Focused on Mental Health During The 28th Annual African American Film Marketplace and…

Posted: August 30, 2022 at 2:54 am

LOS ANGELES, Calif., Aug. 25, 2022 (SEND2PRESS NEWSWIRE) The Black Hollywood Education Resource Center is proud to welcome an incredible lineup of Films, Filmmakers and Healthcare Professionals to the stage of speakers for our 28th Annual Film Festival and First Annual Health Conference: SUPLLEMENTALLY: Mastering Mental and Brain Health After the Pandemic Across the Globe: Recovery, Healing, Hope, Reimage, taking place August 27, 2022, Cinemark 18 & XD, 6081 Center Drive, Los Angeles, CA., 90045 and virtually.

Image Caption: Event poster, 28th Annual Film Festival and First Annual Health Conference.

Just-announced special experts:

historical, intergenerational, interpersonal and community trauma. She also hosts the

podcast Healing is the Revolution in which her guests share and explore their healing journey through their traumas.

During the Black Hollywood Education Resource Centers Annual film festival, we will bring together a distinguished group of mental health experts, affiliates, peers, providers, government officials, media, and key stakeholders to talk about what it means to recover mentally from the COVID-19 pandemic. We continue to see the increasing number of people experiencing anxiety, depression, psychosis, loneliness, suicide, mass shootings and other mental health concerns these past two years, in addition to the largest number of opioid deaths in our history.

The historical landscape and experience of mental health among the African American Community has and remains to be characterized by current and unresolved trauma and violence. To address the impact of mental and brain health in diverse and marginalized communities across the globe, the Black Hollywood Education and Resource Center will also present its first Health Matters Film Block, featuring films focused on mental health.

This years films will help us reimage therapeutic treatments and models of mental health care and to determine ways that we can adequately address the complex challenges of mental illness in marginalized communities, which accounts for approximately one-third of mental illness globally, stated Dr. Shirley Evers-Manly, Dean and Professor, Alcorn State University, who will moderate the session.

During the festival and beyond, participants will discuss alternative ways to heal from trauma and explore the intersecting equity issues that exist. These events unequally affect many African Americans, communities of color and marginalized communities the most, placing them more at risk of a mental health crisis.

These circumstances call for radical change in the paradigm and practices of mental health care, including improving standards of clinician training, and revisioning current models of mental health care delivery. Upon completion of this conference, participants will enhance their knowledge of evidence-based practices to improve the behavioral and clinical skills of nurses, social workers, and other health care professionals who care for persons and families of all ages and cultural / socioeconomic status living with mental illness across the globe through the lens of film and the sound of music.

REGISTRATION AND TICKETS

Event registration is available online at https://bherc.org/bherc-health-matters/

In Person Registration

$50.00- General Admission (4 CEU Credits & Breakfast) | $20.00- Student / Senior(Breakfast)

Live Virtual Attendance

$30.00- General Admission (4 CEU Credits) | $25.00- General Admission | $20.00- Student/Senior

Virtual Attendance

$30.00- General Admission (4 CEU Credits) | $25.00- General Admission | $20.00- Student/Senior

About Black Hollywood Education & Resource Center

Founded in 1996, by Sandra Evers-Manly, BHERC is a 501(c)(3) nonprofit, public benefit organization designed to advocate, educate, research, develop, and preserve the history and future of African Americans in film and television. BHERC programs include film festivals, mentoring, book signings, script readings, film and animation contests, scholarships, and other programs and special events. BHERC recognizes the contributions of African American men and women in front of and behind the scenes in the entertainment industry.

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SPEAKER BIOS

:: Shirley Evers-Manly, PhD, RN, FAAN is the founder and President of All Health Care, Imanis in Oakland, California and Interim Dean Alcorn State University School of Nursing, in Natchez, Mississippi.

She earned a PhD from the University of California, San Francisco, Bachelor of Science Nursing degree and a Master of Science Nursing degree from Samuel Merritt University in Oakland, California. Dr. Shirley Evers-Manly, has more than 35 years of experience developing and implementing clinical, academic, and community-based health promotion and prevention programs; as well as working with vulnerable populations and speaking about diversity locally and abroad. She served as the Principal Investigator for the Aim 2 Care Multiple Chronic Conditions training grant, Bridges to the Doctorate and Song Brown Student Success grants.

She has won numerous prestigious awards for her accomplishments and contributions to improve clinical practices, inpatient and community health outcomes, and academia success and was awarded Congressional Recognition for Outstanding Community Service by the California State Senate and United States Congress. In 2014, she was given the prestigious honor of induction into the Inaugural Leadership Hall of Fame, Sigma Theta Tau International, Honor Society of Nursing, Alpha Eta Chapter (UCSF).

:: Dr. Evers-Manly is an internationally recognized expert in oncology and health disparities throughout the life span. She has made significant contributions in advocating to eliminate health disparities and inequities throughout the world. She gives voice to those who feel they have no voice.

Dr. Evers-Manlys understanding of underserved populations brings a humanistic approach to strategic, safe, high quality and cost-effective healthcareshe has leadership assets and skills from which the health care arena will benefit.

For her significant contributions in the areas of service, scholarship, community, and leadership, she was inducted as a fellow in the American Academy of Nursing, which was established to serve the general public and nursing profession by advancing health policy and practice through the generation, synthesis and dissemination of nursing knowledge. Dr. Evers-Manly is on faculty at the University of California, San Francisco, School of Nursing, is a former Regional Chair for Sigma Theta Tau International Nursing Honor society where 26 nursing honor society chapters reported to her. Currently she serves as member of the National Black Nurses Association and is the Chair of the Associations Ad hoc Committee on the Global Health.

:: Dr. Denese Shervington has an intersectional career in public health and academic psychiatry. She is the Chair of Psychiatry and Professor at Charles R. Drew University. Dr. Shervington has held Clinical Professorships in the Departments of Psychiatry at Columbia University and Tulane University. A graduate of New York University School of Medicine, she also received a Masters of Public Health in Population Studies and Family Planning from Tulane University School of Public Health. She completed her residency in Psychiatry at the University of California San Francisco and is certified by the American Board of Psychiatry and Neurology. A Fellow of the American Psychiatry Association (APA) she is a recipient of the APAs Award for Excellence in Service and Advocacy; prior to which she received the Jeanne Spurlock Minority award. Dr. Shervington is also a member of the American College of Psychiatrists and serves on the Psychiatry Resident-In-Training Commission. Dr. Shervington has testified before the United States Congress on Childhood Trauma and co-chaired the New Orleans City Council Taskforce on Childhood Trauma. She is a member of the Scientific Board of the Centre for Society and Mental Health at Kings College, London. Dr. Shervington has authored several papers in peer-reviewed journals addressing health disparities, the social determinants of health and resilience in underserved communities.

Dr. Shervington is the author of Healing Is the Revolution, a guide to healing from historical, intergenerational, interpersonal and community trauma. She also hosts the podcast Healing is the Revolution in which her guests share and explore their healing journey through their traumas. She is the proud parent of two amazing children Iman and Kaleb, and three grandchildren Ayelet, Haddassah, and Yoav.

:: Dr. Clyde E. Glenn is a native of Cleveland, MS. He graduated from Alcorn State University and completed his medical school education at The University of Iowa College of Medicine in 1990. He completed residency training in Psychiatry at The Ohio State University in 1994 and is Board Certified in Psychiatry and Neurology. Dr. Glenn is the founder and proprietor of Rehoboth Psychiatric Services in Ridgeland, MS. He has over 30 years of experience of psychiatric practice in both outpatient and inpatient settings and treats children and adults across the spectrum of psychiatric disorders. He is president of the Essie B. and William Earl Glenn Family Foundation and the ACEs (Adverse Childhood Experiences) Awareness Foundation of Mississippi.

:: Dr. Stephanie A. Patterson, JD, DNP, MBA, MPA, MSN, RN-BC, PMHNP-BC, FNP-BC, PHN, is a Lifetime Member of the Council of Black Nurses-Los Angeles, a chapter of the National Black Nurses Association (NBNA), Inc. She is a practicing healthcare provider in California and a nurse scholar with a passion for providing high-quality, appropriate, patient-centered psychiatric care to clients who are from traditionally underserved and/or historically marginalized communities.

As a nurse leader, Dr. Patterson serves on the NBNA Ad Hoc Collaborative Committee on Mentorship, a program aimed at helping NBNA nurses/student nurses at various levels of their development. She enjoys mentoring nursing students through the NBNA Collaborative Mentorship Program, for the purpose of increasing the number of BIPOC nurses in the workforce.

Her long history of academic achievements, community-based accomplishments, as well as a demonstrated history of excellence in the clinical setting while improving client outcomes, makes her stand out. A highlight of some of the awards Dr. Patterson has received in the recent past include the 2022 Nurse Practitioner of the Year Award (San Francisco Bay Area), 2017 Millennial Nurse of the Year Award, 2016 NBNA Under 40 Award, and the 2015 NBNA Student Nurse of the Year Award. She also served as a Student Board Representative while enrolled in nursing school.

:: Tia Delaney, MSN-Ed, RN, CCM Born in Boston, MA, Tia currently holds a masters degree in nursing with an emphasis in education and

is a certified clinical case manager. As a registered nurse, with over 28 years in the healthcare industry, and having previous roles within those organizations as Director of Patient Care Services, Chief Operating Officer, and Administrator, Tia has overseen the various facets required to deliver quality and competent clinical care to thousands of home health, palliative, hospice, and hospital-based clients. With a focus on the baby-boom and geriatric population, she understands the current healthcare plight America is facing and remains a passionate and dedicated advocate for the enhancement of healthcare services to the frail, vulnerable, and elderly members within the community.

Her direct observation of the healthcare inequities, social determinants of health, and lack of clinician diversity within the Los Angeles population that she served, has led her to collaborate with various organizations to design policies, procedures, regulations, and resources, to improve the health-related outcomes of the marginalized and underserved. Innovation, leadership, and initiative are just a few of the qualities that define her work-ethic.

As Director of Diversity, Equity, and Inclusion for the Alzheimers Association, her goals are to cultivate relationships with diverse communities which includes sharing time, talent, resources, and exchanging ideas to ensure neutrally fair access to opportunities, resources, and fiscal support. Additionally, she oversees the organizations mission of creating and maintaining a culture of inclusivity to its diverse constituents and ensure interests and needs are welcomed and fully considered within its multiple communication platforms, mission activities, and business practices. As a commitment to paying it forward, Tia is a clinical instructor teaching both theory and clinical skills to our nations future nurses. Additionally, she volunteers her time providing community-based health & wellness seminars which focus on providing education and resources to empower others in areas such as chronic disease management, preventative care, and holistic-health awareness.

:: Dr. Pedro E. Morante DNP, LNC, PMHNP-BC, FNP-BC, NP-C, GERO-BC, MEDSURG-BC, PMH-BC, is a mental health advocate and a dual board certified as Family and Psychiatric Nurse Practitioner at Brain Health USA and Assistant Professor in the School of Nursing. He holds a Doctorate of Nursing Practice with subspecialty of PMHNP from Brandman University. He graduated from Charles R. Drew University with his MSN focusing on Family Nurse Practitioner track. He is also a dual board certified through AANP and American Nurses Credentialing Center as a FNP as well as a Psychiatric Mental Health Nurse Practitioner (PMHNP) through ANCC.

Dr. Morante has cared for adolescent and adult patients in a variety of settings, including in-patient hospitals, community group homes, and out-patient practices. He has dedicated much of her nursing career to working with individuals with geriatric and psychiatry across lifespan.

Dr. Morantespecializes in behavioral health and treating adults with i complex medical and behavioral conditions. In addition, he is the CEO of Morante and Associates Training Center. As both a clinical practitioner and professor, he has gained extensive experience delivering telehealth services to patients and educating nurse practitioners on using telehealth to improve access to care.

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Caption: Event poster.

News Source: Black Hollywood Education and Resource Center

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The Antitumor Effects of Quercetin – The Epoch Times

Posted: August 30, 2022 at 2:54 am

This remarkable compound is racking up an impressive list of research-backed therapeutic credentials

Quercetin has a wide range of benefits, which has made it useful for a variety of different health conditions. In the past two years, the antiviral benefits of quercetin have been the focus of many studies. However, there are other, lesser-known benefits, including the effects as a senolytic agent against senescence-mediated cancer growth.

Cells become senescent as we age. They stop dividing and enter a kind of stasis. Instead of dying off as cells normally do, senescent cells persist but change shape and size and secrete inflammatory molecules that cause other nearby cells to become senescent. This process is one of the hallmarks of human aging and senolytic agents used to induce the death of senescent cells.

Quercetin is perhaps most well-known as a strong antioxidant and antiviral. For example, Elderflower extract, which is rich in quercetin, is a traditional tonic used to boost immunity. In supplement form, quercetin has been used to prevent and treat the common cold and influenza.

According to Mount Sinai, quercetin should be used with caution as it may interact with certain antibiotics by reducing the effectiveness of the drug. It may also enhance the effect of some blood thinners, which can increase your risk of bleeding. In addition to these, it may interact with corticosteroids, digoxin, cyclosporine, and fluoroquinolones.

A paper published in August 2022 in Nutrition Research analyzed the pro-apoptotic effect that quercetin has on aging cells. Apoptosis is the normal, healthy way cells are supposed to die. The paper reviewed preclinical and early phase data using quercetin as a senolytic agent and found the data showed it was effective in preventing or alleviating cancer formation.

The authors reviewed the importance of cellular aging in the development of cancer cells and the effect that quercetin may have on the suppression of cancer cell proliferation. Research has found that cellular aging can suppress tumor development, but paradoxically can also enhance cancer development.

Cellular senescence is a dynamic and multi-step process that is associated with alterations in metabolic activity and gene expression. This can compromise tissue regeneration and contribute to aging. On the other hand, by removing senescent cells, age-related dysfunction can be attenuated and potentially extend the lifespan.

One mini review published in Cancer Letters in 2008 looked at previous research and found that animal studies had demonstrated quercetin could prevent chemically induced cancer growth and epidemiological studies found it was associated with preventing lung cancer. One study focused on the effect that physiologically attainable doses of quercetin had on the inhibition of cancer cell proliferation. The researchers believed their study demonstrated quercetin had chemopreventive properties.

Lab studies have also demonstrated that quercetin is a strong antioxidant and has pro-apoptotic effects on tumor cells, with the ability to block growth at different phases of the cell cycle. Research has also demonstrated that quercetin can promote the loss of cell viability and autophagy through several pathways, including those involving mitochondrial function and glucose metabolism.

Data indicate that quercetin could play a role in cancer treatment as it reportedly has synergistic effects in combination with chemotherapy agents or radiation therapy. Quercetin also has shown promising results with chemoprotective and radioprotective properties, by protecting normal cells against the effects of chemotherapy and radiation therapy.

One paper identified some of the anti-inflammatory, antioxidant and antiproliferative properties quercetin has that enhances breast cancer treatment, while another18 evaluated its effect on the treatment of ovarian cancer, which is a serious cancer growth and threat to womens health.

The strength of the antioxidant properties of quercetin is likely one factor in the ability to improve mood-related behaviors in animal studies in which the subjects underwent sleep deprivation. A study published in 2022 used a sleep deprivation model using 30 male albino mice. The mice were split into five groups.

The intervention groups received either astaxanthin or one of two doses of quercetin. Their activities were monitored, and brain samples were later collected. Researchers found that during persistent wakefulness, the animals experienced anxiety and depression-like behavior. In the sleep-deprived group, brain samples showed increased prooxidant activity. Prooxidants induce oxidative stress.

In the group pretreated with quercetin, these behaviors were reversed. The researchers found that quercetin could reduce anxiety caused by sleep deprivation in the animals. The structure of this study was similar to another published in 2021, in which the researchers split the animals into five groups that received the same intervention and sleep deprivation just described.

The researchers hypothesized, and the data showed, that quercetin ameliorated the effects of sleep deprivation on memory performance, depression-like behavior, and against the loss of prefrontal cortex neurons. Researchers have been interested in how the powerful antioxidant effects of quercetin might mitigate the damage and impairment commonly found following sleep disruption.

In one study published in 2016, the researchers hypothesized that quercetin could reduce the manic-like behavior induced by 24 hours of paradoxical sleep deprivation in mice. Paradoxical sleep is another name given to rapid eye movement (REM) sleep, the deprivation of which has led to chronic conditions such as obesity and stress disorders in people.

In the animal study, the researchers found that quercetin blocked hyperactivity that was induced by sleep deprivation. In another study, researchers hypothesized that the deficits in the hippocampal area associated with sleep deprivation could be ameliorated with a preparation of grape seed polyphenol extract, concord grape juice, and resveratrol.

They found the preparation improved sleep deprivation-induced memory deficits and quercetin, found in grape seed extract and grape juice, was an important factor in attenuating cognitive impairment caused by acute sleep deprivation.

Quercetin has been studied for its antiviral effect and has proven to inhibit the early stages of a flu infection. It is also a promising agent against the Epstein-Barr virus, Zika virus, Hepatitis B, and rhinovirus, the virus most often responsible for the common cold.

It was only logical then, as the COVID-19 pandemic emerged, that researchers would investigate the efficacy of quercetin against the SARS-CoV-2 virus. In the early months of the declared pandemic, a review was published that found the administration of bromelain, quercetin, vitamin C, and zinc showed promising results in improving clinical outcomes among COVID-19 patients.

In this paper, the researchers identified the antioxidants ability to inhibit proinflammatory cytokines and to clinically block human mast cell cytokine release as an important property in the fight against severe COVID-19 disease, which is associated with increased levels of cytokine production. They also identified the independent actions that bromelain has in activating a healthy immune system.

However, bromelain and vitamin C play another role in the administration of quercetin. Because quercetin generally isnt soluble in water, it can be poorly absorbed. When administered with bromelain or vitamin C, it increases the absorption and bioavailability of the antioxidant.

Bromelain is a proteolytic enzyme found in the stem of the pineapple plant. Independently, it has been used as a supplement to help reduce swelling after surgery or injury, or in the nose and sinuses. Its also applied topically to help treat burns.

The combination of quercetin with bromelain or vitamin C has also been a part of several successful protocols used to treat COVID-19. Quercetin is a zinc ionophore, which helps improve the cells ability to absorb zinc where it is effective as an antiviral.

Dr. Vladimir Zelenko was among the first physicians to discover and implement a treatment that has been credited with saving millions of lives around the world. His early protocol used hydroxychloroquine, another zinc ionophore. However, as research data showed that quercetin was as effective as hydroxychloroquine, his early treatment options for low-risk patients included quercetin with vitamin C and zinc.

Sadly, Zelenko died on June 30, at the age of 48 after a long battle with cancer. While treating patients, he oversaw the treatment of roughly 7,500 people using his protocol, during which time only three patients died.

The antioxidant and anti-inflammatory health benefits of quercetin likely contribute to the other lesser-known benefits of this supplement. The anti-inflammatory effects of quercetin are crucial since inflammation is at the root of many diseases, including autoimmune disorders, heart disease, and cancer.

One review of the literature found quercetin is a strong anti-inflammatory weapon that may be used in the fight against inflammatory diseases, such as obesity and type 2 diabetes. Another revealed that supplementation could reduce systolic blood pressure, and a third animal study demonstrated that supplementation with quercetin and exercise could reduce atherosclerotic plaque formation.

Quercetin has also shown promise in relieving the symptoms of allergies. It works by inhibiting histamine release and decreasing proinflammatory cytokine production and leukotrienes creation. The combination of quercetin and bromelain or vitamin C has also been promoted to help improve athletic performance based on the antioxidant potential of both flavonoids.

Quercetin has also been studied for the positive health benefits it has on:

Considering the wide-ranging benefits that quercetin has on human health, it could be a useful supplement for many, whether its used to treat an acute or chronic condition or as a long-term preventative measure. Its one of the supplements I recommend keeping in your medicine chest for times when you may be feeling as if youre getting an upper respiratory infection. If youre prone to colds and flu, consider taking it for a couple of months before the cold and flu season hits to support your immune system.

If you feel as if you have a cold or flu, consider using quercetin with bromelain or vitamin C in addition to zinc. Over-the-counter zinc lozenges make it easy to consume zinc for the short time its needed when youre feeling ill. Be sure to eat before taking zinc as it can make you nauseous.

On a long-term basis, quercetin has been useful for those with metabolic syndrome. However, it is much better to address fundamental issues to deal with metabolic syndrome, such as fixing a poor diet or getting enough exercise, and use a supplement only as an adjunctive therapy. If you have one or more conditions that make up metabolic syndrome, you would be wise to limit your total sugar intake to 15 grams per day.

For comparison, the American Heart Association61 reports that the average adult consumes 77 grams of sugar each day, which is more than three times the recommended amount for women. The number for children is even worse, with the average American child consuming 81 grams of sugar per day. Sugar-laden beverages are the leading source of added sugars in the diet.

Quercetin can function in several pathways to help reduce your risk of cancer. In addition to reducing the inflammatory response in your body and thus your risk of obesity and obesity-related cancer, it also promotes apoptosis at the cellular level to prevent cancer. When combined with exercise and reduced sugar consumption, you are making strong steps toward taking control of your health.

Sources and References

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Boosting Neuron Formation To Restore Memory in Alzheimers Disease – SciTechDaily

Posted: August 30, 2022 at 2:53 am

Researchers have discovered that boosting neuron formation restores memory in mice with Alzheimers disease.

Scientists have discovered that increasing the production of new neurons in mice with Alzheimers disease (AD) rescues the animals memory defects. The study shows that new neurons can incorporate into the neural circuits that store memories and restore their normal function. This suggests that boosting neuron production could be a viable strategy to treat AD patients. The study, which was published on August 19 in the Journal of Experimental Medicine (JEM), was done by researchers at the University of Illinois Chicago.

New neurons are created from neural stem cells via a process known as neurogenesis. Previous studies have shown that neurogenesis is impaired in both AD patients and laboratory mice carrying genetic mutations linked to AD. This impairment is especially serious in a region of the brain called the hippocampus, which is crucial for memory acquisition and retrieval.

However, the role of newly formed neurons in memory formation, and whether defects in neurogenesis contribute to the cognitive impairments associated with AD, is unclear, says Professor Orly Lazarov of the Department of Anatomy and Cell Biology at the University of Illinois Chicago College of Medicine.

The new study shows that boosting neurogenesis increases the number of newly formed neurons involved in storing and retrieving memories (arrows) in the hippocampus of mice with AD. Credit: 2022 Mishra et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20220391

In the new JEM study, Lazarov and his colleagues boosted neurogenesis in AD mice by genetically enhancing the survival of neuronal stem cells. The scientists deleted the gene Bax, which plays a major role in neuronal stem cell death, ultimately leading to the maturation of more new neurons. Increasing the production of new neurons in this manner restored the animals cognitive performance, as demonstrated in two different tests measuring spatial recognition and contextual memory.

By fluorescently labeling neurons activated during memory acquisition and retrieval, the scientists discovered that, in the brains of healthy mice, the neural circuits involved in storing memories include many newly formed neurons alongside older, more mature neurons. These memory-storing circuits contain fewer new neurons in AD mice, but the integration of newly formed neurons was restored when neurogenesis was increased.

Further analyses of the neurons forming the memory-storing circuits revealed that boosting neurogenesis also increases the number of dendritic spines. These are structures in synapses known to be critical for memory formation. Plus, boosting neurogenesis also restores a normal pattern of neuronal gene expression.

Lazarov and colleagues confirmed the importance of newly formed neurons for memory formation by specifically inactivating them in the brains of AD mice. This reversed the benefits of boosting neurogenesis, preventing any improvement in the animals memory.

Our study is the first to show that impairments in hippocampal neurogenesis play a role in the memory deficits associated with AD by decreasing the availability of immature neurons for memory formation, Lazarov says. Taken together, our results suggest that augmenting neurogenesis may be of therapeutic value in AD patients.

Reference: Augmenting neurogenesis rescues memory impairments in Alzheimers disease by restoring the memory-storing neurons by Rachana Mishra, Trongha Phan, Pavan Kumar, Zachery Morrissey, Muskan Gupta, Carolyn Hollands, Aashutosh Shetti, Kyra Lauren Lopez, Mark Maienschein-Cline, Hoonkyo Suh, Rene Hen and Orly Lazarov, 19 August 2022, Journal of Experimental Medicine.DOI: 10.1084/jem.20220391

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Reebok Nano X2 Adventure Review: A Wild Way to Log Your Workouts – Gear Patrol

Posted: August 30, 2022 at 2:52 am

Outdoor workouts have plenty of positives. No confined spaces. Fresh air. Plenty of Vitamin D from the sun. But sometimes, our normal gym attire isn't suited for these open spaces. For example, while gym shoes can be great for providing support under the squat bar or moving across rubberized floors, the outsoles and uppers might not be the best for tackling tougher or grassier terrain.

To bridge the gap between indoor and outdoor training, Reebok has unveiled an all-new training sneaker for those looking for more wild workouts. The Nano X2 Adventure builds off the already-impressive Nano X2, boasting a durable nylon ripstop upper, updated outsole and outdoor-inspired screen prints and reflective style notes.

But is this hybrid trainer capable of tackling any training scenario? Do the updated specs make this silhouette a true adventurer or simply a weekend tourist? To find out, I strapped up in these wild gym shoes for a number of disciplines, ranging from the typical gym session, to outdoor agility drills, plyometrics, short trail runs and more. Here's what I discovered.

Reebok

Reebok Nano X2 Adventure

One of the first things I noticed about the new Nano X2 edition outside of the eye-catching colorway was the deeper, more rugged outsole. The tread pattern is designed for optimal outdoor traction, and believe me, it's grippy enough for any outdoor fitness regimen. I had no issues finding my footing when performing agility drills on grassed or turf fields, and felt supported when swinging steel maces or throwing medicine balls, too. I even ventured out to a few short packed walkways and hiking trails to see how these kicks would fare, and found no issues staying upright through my treks.

You could best think of the Nano X2 Adventure as the all-terrain version of the traditional Nano X2. While you can get by with normal tread, these updated sneakers just make it a much easier, more enjoyable experience.

I was already a fan of the breathable Flexweave knit upper of the Nano X2, but I wouldn't necessarily consider it to be an outdoor-ready build. The nylon ripstop upper of the X2 Adventure, however, is more than capable of taking on the wild. The material easily defended against branches and overgrown trailways when hiking through some less-than-stellar routes. Additionally, I never noticed any scarring or deterioration when scraping across turf or grass. The synthetic overlays across the toe box were also nice additions to help maintain that impressive, clean silhouette.

While the nylon ripstop upper kept plenty of obstacles out of the shoe, it didn't do too much in letting in refreshing air. When on-pavement workouts lasted more than an hour, or when my trail runs crossed the 3-mile mark, I began to feel my feet clamoring for some much-needed ventilation. For this reason, I'd often find myself packing an extra pair of sandals to wear post-training, just to give my feet some time to breathe.

While I don't think this is an absolute dealbreaker for the Nano X2 Adventure they do provide some breathability I do think its worth mentioning, especially for individuals that favor longer outdoor training sessions.

The Nano X2 Adventure also showcases a different boot design than its X2 predecessor, with an updated heel collar for enhanced comfort. This feature adds some plush and coziness when you're out and about, but there's an added seam at the ankle, which can create a crease and opening when running. I noticed this most when traversing downhill trails, as I began to see a slight space between the shoe's boot and my ankle.

While this design isn't uncomfortable, it does leave room for errant rocks and debris to get inside your sneaker. If you're running or hiking on looser terrain, this could lead to some inconveniences underfoot.

These outdoor-ready training shoes are exceptional for taking your agility training, plyometrics and strength workouts outside. The Nano X2 Adventures are also capable footwear options for light hikes and short trail runs, but outside of these disciplines, I wouldn't recommend them for pushing the absolute limits of fitness. They're suitable for a variety of modalities, but not necessarily a master at one particular style.

Starting today, the Nano X2 Adventure is available online for $140, just $5 more than the traditional Nano X2. If you're looking for a trainer with a little more bite and little more durability, these could be a great option. Will they help you conquer the most technical trail runs? No. Can they be an enjoyable hybrid giving your workouts some room to roam outdoors? Resoundingly, yes.

Reebok

Reebok Nano X2 Adventure

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PhD within Particle Engineering job with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY – NTNU | 306487 – Times Higher Education

Posted: August 30, 2022 at 2:52 am

About the position

The Particle Engineering Centre (https://www.ntnu.edu/web/chemeng/particle-engineering-centre) at the Department of Chemical Engineering has a vacancy for a PhD student within the broader thematic area of nanoparticles in biomedicine with special focus on particle design and characterization. The earliest start date for the position will be November 2022.

The appointment has a duration of 4 years including 25% teaching duties in agreement with the department.

For a position asaPhD Candidate,the goal is acompleted doctoral education up toan obtaineddoctoral degree.

Nano-technology is a strategic research area at NTNU. The application of nanotechnology to medicine has shown great promise in diagnostics, imaging, therapy among others. The Particle Engineering Centre at the Department of Chemical Engineering at NTNU was established in early 2021.

The basis for the research in the Centre is an extensive experience at the department within particle synthesis and characterization, which quite recently was put into practical application as part of the COVID-19 test method developed at NTNU (https://www.ntnu.edu/ntnu-covid-19-test). The objective of the Centre is to advance the scientific knowledge within fundamental and applied particle engineering. Ongoing research activities focus on synthesis, characterization and tailoring of particles for use in nanomedicine and environmental applications.

Project Description

This is an open PhD position where the candidate is expected to submit a research proposal that fits within the nanomedicine thematic research area of the Centre. The proposal should emphasize on particle design and characterization and target one or more of the applications - biosensing, diagnostics, imaging and/or drug delivery.

In the proposal, the candidate is expected to:

Some general guidelines for the proposal that must be followed.

Evaluation criteria for the proposal.

Duties of the position

Required selection criteria

The PhD-position's main objective is to qualify for work in research positions

Essential Qualifications

The appointment is to be made in accordance with Regulations concerning the degrees ofPhilosophiaeDoctor (PhD)andPhilosodophiaeDoctor (PhD) in artistic researchnational guidelines for appointment as PhD, post doctor and research assistant

Personal characteristics

In the evaluation of which candidate is best qualified, emphasis will be placed on education, experience and personal suitability.

We offer

Salary and conditions

As a PhD candidate (code 1017) you are normally paid from gross NOK 501 200 per annum before tax, depending on qualifications and seniority. From the salary, 2% is deducted as a contribution to the Norwegian Public Service Pension Fund.

The period of employment is 4 years including 25% teaching duties in agreement with the department.

Appointment to a PhD position requires that you are admitted to the PhD programme in Chemical Engineering (https://www.ntnu.edu/chemeng) withinthree months of employment, and that you participate in an organized PhD programme during the employment period.

The engagement is to be made in accordance with the regulations in force concerningState Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. Candidates who by assessment of the application and attachment are seen to conflict with the criteria in the latter law will be prohibited from recruitment to NTNU. After the appointment you must assume that there may be changes in the area of work.

The position is subject to external funding.

It is a prerequisite you can be present at and accessible to the institution daily.

About the application

The application and supporting documentation to be used as the basis for the assessment must be in English.

Publications and other scientific work must follow the application. Please note that your application will be considered based solely on information submitted by the application deadline. You must therefore ensure that your application clearly demonstrates how your skills and experience fulfil the criteria specified above.

The application must include:

If all,or parts,of your education has been taken abroad, we also ask you to attach documentation of the scope and quality of your entire education, both bachelor's and master's education, in addition to other higher education. Description of the documentation required can befoundhere. If you already have a statement fromNOKUT,pleaseattachthisas well.

We will take joint work into account. If it is difficult to identify your efforts in the joint work, you must enclose a short description of your participation.

The position requires spoken and written fluency in the English language. Applicants from non-English-speaking countries outside Europe must document English skills by an approved test. Approved tests are TOEFL, IELTS and Cambridge Certificate in Advanced English (CAE) or Cambridge Certificate of Proficiency in English (CPE).

In the evaluation of which candidate is best qualified, emphasis will be placed on education,experienceand personal and interpersonalqualities.Motivation,ambitions,and potential will also countin the assessment ofthe candidates.

NTNU is committed to following evaluation criteria for research quality according toThe San Francisco Declaration on Research Assessment - DORA.

General information

Working at NTNU

NTNU believes that inclusion and diversity is our strength. We want to recruit people with different competencies, educational backgrounds, life experiences and perspectives to contribute to solving our social responsibilities within education and research. We will facilitate for our employees needs.

The city of Trondheimis a modern European city with a rich cultural scene. Trondheim is the innovation capital of Norway with a population of 200,000. The Norwegian welfare state, including healthcare, schools, kindergartens and overall equality, is probably the best of its kind in the world. Professional subsidized day-care for children is easily available. Furthermore, Trondheim offers great opportunities for education (including international schools) and possibilities to enjoy nature, culture and family life and has low crime rates and clean air quality.

As an employeeatNTNU, you must at all times adhere to the changes that the development in the subject entails and the organizational changes that are adopted.

A public list of applicants with name, age, job title and municipality of residence is prepared after the application deadline. If you want to reserve yourself from entry on the public applicant list, this must be justified. Assessment will be made in accordance withcurrent legislation. You will be notified if the reservation is not accepted.

If you have any questions about the position, please contact Associate Professor Sulalit Bandyopadhyay (Department of Chemical Engineering) telephone +47 4507 1041, email sulalit.bandyopadhyay@ntnu.no

If you have any questions about the recruitment process, please contact HR Advisor Nina Sandberg (Department of Chemical Engineering), e-mail: nina.sandberg@ntnu.no

If you think this looks interesting and in line with your qualifications, please submit your application electronically via jobbnorge.no with your CV, diplomas and certificates attached. Applications submitted elsewhere will not be considered. Upon request, you must be able to obtain certified copies of your documentation.

Application deadline: 16.09.22

NTNU - knowledge for a better world

The Norwegian University of Science and Technology (NTNU) creates knowledge for a better world and solutions that can change everyday life.

Department of Chemical Engineering

We take chemistry from laboratory scale to industrial production. This demands a wide range of knowledge, from molecular processes and nanotechnology to building and operation of large processing plants. We educate graduates for some of Norway's most important industries. The Department of Chemical Engineering is one of eight departments in the Faculty of Natural Sciences.

Deadline16th September 2022EmployerNTNU - Norwegian University of Science and TechnologyMunicipalityTrondheimScopeFulltimeDuration TemporaryPlace of service Trondheim

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PhD within Particle Engineering job with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY - NTNU | 306487 - Times Higher Education

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Scientists convert kidney to universal O blood type – Freethink

Posted: August 30, 2022 at 2:50 am

For transplant candidates from ethnic minorities, the wait for an acceptable organ can be even more grueling than for others.

Type B blood is more common in minority communities, making type A organs incompatible.

But a breakthrough by Cambridge researchers could dramatically change the rules for transplant compatibility.

In a recent experiment, they changed a kidneys blood type from A to the universal type O making it theoretically available for any patient, including those with type B blood.

Type B blood is more common in minority communities, making type A organs incompatible.

We know that people from minority ethnic groups can wait much longer for a transplant as they are less likely to be a blood-type match with the organs available, Aisling McMahon, the executive director of research at charity Kidney Research UK, which funded the work, said.

This research offers a glimmer of hope to over 1,000 people from minority ethnic groups who are waiting for a kidney.

I feel sad at the thought of waiting so long: Ayesha was diagnosed with stage 3 kidney disease in 1998, and lived with the disease until the pandemic, when her kidneys began to deteriorate quickly.

Put on the transplant list, she was told she may need to wait twice or even three times as long as a white patient.

They explained that because of my ethnicity my wait for a deceased donor will be longer than for a white person, she told Cambridge.

In the UKs Muslim commnuity, kidney disease is common but not talked about, says Ayesha, who recently began volunteering for Kidney Research UK.

I feel sad at the thought of waiting so long for a transplant, I understand a transplant isnt a cure, but it would make my body a lot stronger and give me a second chance at a healthy life.

The Cambridge work, led by professor of transplant surgeon Mike Nicholson and PhD student Serena MacMillan, may help patients like Ayesha become eligible for kidneys much faster, if it is proven safe and effective in the clinic.

To your body, transplanted organs need to be attacked like viruses or tumors, and non-matching blood types exacerbate the issue.

Changing types: To your body, a transplanted organ is something alien that needs to be attacked just like bacteria, viruses, tumors, and parasites.

Non-matching blood types exacerbate this issue.

One of the biggest restrictions to who a donated kidney can be transplanted to is the fact that you have to be blood group compatible, Nicholson said.

The reason for this is that you have antigens and markers on your cells that can be either A or B. Your body naturally produces antibodies against the ones you dont have.

To change a kidney to type O which can be universally accepted the team took aim at those antigens.

Using a machine called a normothermic perfusion machine, they flushed three deceased donor kidneys with blood containing an enzyme that works like a pair of molecular scissors, slicing out those A or B antigen blood markers.

With those markers stripped away, the kidneys became type O in just a few hours.

Our confidence was really boosted after we applied the enzyme to a piece of human kidney tissue and saw very quickly that the antigens were removed, MacMillan said, referring to an earlier experiment.

After this, we knew that the process is feasible, and we just had to scale up the project to apply the enzyme to full-size human kidneys.

The teams research is scheduled to be published in coming months in the British Journal of Surgery. Similar work has previously been performed in lungs.

The great hurdle: In my previous reporting on the field, Ive been told that rejection of organs is, essentially, the only limit to transplant surgery, according to top-flight transplant surgeons at Massachusetts General, Johns Hopkins, and South Africas Stellenbosch University.

The immune systems attack on alien tissue can be defeated in various ways, including the standard approach: lifetime immunosuppression. While this often works, it also leaves the body highly vulnerable to infection and still does not guarantee the organ wont be rejected eventually.

The team flushed the kidneys with special enzymes to convert them to blood type O the universal donor.

Researchers are racing to find other ways to prevent organ rejection, including transplanting bone marrow tissue at the same time, to fool the body into thinking the organ is natural known as mixed chimerism and, more rarely, essentially transplanting a whole new immune system via stem cells.

The Cambridge researchers hope their technique may join that growing toolbox, although it is important to note the research is still ongoing.

Using the same machine they used to change the kidneys blood type, the team will now test how the freshly christened type O kidneys react to blood of different types, a simulation of what will happen when introduced to a patient.

From there, they will begin figuring out how to test the technique with transplant patients.

The research will offer so much hope to minority groups still waiting for a transplant and could help to save many lives, Ayesha said.

Wed love to hear from you! If you have a comment about this article or if you have a tip for a future Freethink story, please email us at [emailprotected]

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McDermott: Pinner may have been crackers, but in today’s GOP, she was practically normal – St. Louis Post-Dispatch

Posted: August 30, 2022 at 2:48 am

St. Louis County Republicans last week surely feel they dodged a bullet with the exit from the November ballot of Katherine Pinner, who was briefly the partys nominee for St. Louis County executive. Whatever issues shed hoped to focus on in her campaign, the real issue would have been the lawsuit she filed against her former employer alleging that its mask mandate was satanic and that getting vaccinated displeases God.

Pinner thus took her place among a long line of loons in elective politics these days. Not all, but most, hail from the rightward side of the political spectrum. Which invites some legitimate questions about what has happened to the once-sober conservative movement.

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Pinner is the 55-year-old political novice who emerged from out of nowhere this month to win the Republican nomination for the countys top political post. Online, she had voiced beliefs consistent with QAnon, the culty crowd that thinks a dark world of all-encompassing conspiracies hums just beyond plain sight a good-versus-evil epic that casts Donald Trump, improbably, as the former.

Pinners posts pointed out that if you replaced each B in President Bidens Build Back Better legislation with 6, youd end up with the mark of the devil. As voters started catching onto this plan of 6uild 6ack 6etter, the democrats quickly changed their slogan, she wrote. (Shes right. I remember the memo from headquarters.)

She suggested that coronavirus vaccines were laced with nanotechnology designed to bar code nine billion people in order to inventory them.

Its all connected, she warned.

Because, yknow, its always all connected.

After winning the Aug. 2 primary, Pinner apparently got some good advice and did some online house cleaning to remove indications that she is, well, crackers. But it seems she couldnt rein in her demons for long. The $1.2 million lawsuit Pinner filed last week against her former employer, the American Association of Orthodontists, for its pandemic policies, alleges that vaccines prompt transhumanism changes in the body that can lead to being barred from Gods graces. And it claims mask-wearing is associated with dehumanization and satanic ritual abuse.

In the latest head-spinning twist, Pinner late Thursday told the county Republican chair she plans to drop out of the race, without explaining why. Its a welcome if undeserved reprieve for the party, which can now put someone less demonstrably loopy on the ballot.

But the question remains: Why do Republicans, here and around America, keep nominating candidates who, if they approached them on the sidewalk, would prompt them to cross the street?

The poster-child for this phenomenon, of course, is Rep. Marjorie Taylor Greene, R-Georgia. Evidence of her psychosis is too voluminous to detail here, so lets leave it at her suggestion that Californias wildfires were caused by space-based lasers controlled by a cabal of Jewish overlords.

Rep. Lauren Boebert, R-Colorado, hasnt achieved quite that level of bonkers, but its not for lack of effort. Among her litany of lunacy was a speech in June declaring, The church is supposed to direct the government Im tired of this separation of church and state junk thats not in the Constitution. (Narrator: Except in the very first words of the very first amendment in the Bill of Rights.)

Republican candidates coming up through this years congressional primaries promise more of this derangement. Even Senate Minority Leader Mitch McConnell who has more motive than anyone to get Republicans seated, no matter the details recently worried aloud that his party might fail to take back the Senate because of what he diplomatically called candidate quality issues.

Dr. Mehmet Oz, Pennsylvanias Republican Senate nominee, has pushed such quack remedies that it prompted an essay in the normally staid Scientific American headlined: Dr. Oz Shouldnt Be a Senator or a Doctor. Arizona Republicans have nominated to the Senate 36-year-old Blake Masters, who has praised the anti-tech manifesto of Ted Unabomber Kaczynski. In Georgia, GOP Senate nominee Herschel Walker the former NFL star who has already been in the politically awkward position of having to issue clarifications to the media regarding how many children he has fathered by how many women bashed Bidens new climate law last week by asking, Dont we have enough trees around here?

Then (as always) theres Florida Gov. Ron DeSantis, who last week lambasted Dr. Anthony Fauci at a fundraising event. Fauci, the federal governments top infectious-disease expert, is retiring in the face of conservative fury over his allegiance to science instead of Trump. But thats not good enough for DeSantis, who told the crowd that someone needs to grab that little elf and chuck him across the Potomac. Its worth noting that this elevated rhetoric comes from the man who many Republicans view as the more-sane alternative to Trump for the GOPs 2024 presidential nomination.

Despite the controversy surrounding Pinners brief presence on the St. Louis County ballot, she perhaps shouldnt completely discount a future in the GOP. At the rate its going, todays Republican Party will likely have a place for people like her for a long time to come.

Kevin McDermott is a Post-Dispatch columnist and Editorial Board member. On Twitter: @kevinmcdermott Email: kmcdermott@post-dispatch.com

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Stray – A simple and focused game in a world of games that go astray – Flayrah

Posted: August 30, 2022 at 2:48 am

Okay, this one may not technically be a furry game. If the late Fred Patten were to start this review off, he may have asked something along the lines that if you as a player moves around the world as a cat with a robot companion augmenting their ability to interpret the society around them, is that game actually anthropomorphic? Perhaps its more in line with transhumanism, but in this case more transfelinism, where your feline character is augmented by their technological companion.

And like Adam Jensen of Deus Ex: Human Revolution, the cat you play certainly didnt ask for this.

The opening of the game reminded me of Milo and Otis, an old movie of a dog and a cat that end up getting lost in the woods and need to make their way back home. Basically it was the predecessor of Homeward Bound: The Incredible Journey. In this case, the unnamed feline protagonist you play as is just catting around with other cats when you find yourself in trouble and are separated from your companions and fall down into a strange lost society of automatons.

You go on your own heros journey through this strange world that has established itself under what appears to be a giant blast shield facility. In order to return to the surface youll need to help your new robot friends, while avoiding the perils of an invasive species that has taken root in the darkness of this underworld.

While the game has been noted to be on the shorter side, it is very much a complete and contained experience. It has moments of tension and balances it well with a cathartic sense of discovery and exploration. I noted while playing that the designer definitely took inspiration from Valve works, and this includes their understanding of Battle Fatigue.

Things can work their way to a bit of an intensity when dealing with the headcrab like creatures that want to chew on your cat hide, but your moments of fleeing and fighting are spaced out where it doesnt become fatiguing.

The world is fun and immersive and the robot characters are interesting. There are certain embellishments that were fun, such as a fully functioning pool table in the bars that you can bat the ball around with your paws. Desks are littered with items to knock down, though disappointingly it doesnt cause frustrations if the owner of said desk watches you knock things off like the true feline you are.

I would recommend this game if you are a curious sort, you know, like a cat. You like to explore places and enjoy the story of a exotic society. If youre the kind that likes a more visceral or reaction based game of skill, you may not enjoy it so much. Take your time and take in the environment around you and youll get the most out of it. Talk to as many folks as you can and do the tasks they ask of you to get the most out of it. Heck, you can even nap around and take in the world as the camera pans out. Because cats like their naps.

Not much to say, its a short game and its mostly the story which I cant go into without spoiling things. Its a nice and contained experience that should you enjoy its premise enough, youll come back to experience it again like a film or a book. Its sometimes refreshing to experience a game that is a contained experience rather than one that expects to be a service it sells to you for the next decade.

To me, I would rather pay 30 bucks for a complete and enjoyable experience even if it is short, then to get it for free and go through a bunch of immersion breaking microtransactions. If that is too pricey for you for a seven hour experience, then you can feel free to wait for the price point to come down.

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Stray - A simple and focused game in a world of games that go astray - Flayrah

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Could Stem-Cell Based Therapy Treat Type-1 Diabetes? A New Study Demonstrates the Treatments Potential – SciTechDaily

Posted: August 30, 2022 at 2:46 am

The findings suggest stem cell-based replacement therapy has the potential to manage blood sugar levels and may eventually replace the requirement for external insulin injections or dosing.

A clinical study presented at ENDO 2022, the Endocrine Societys annual meeting in Atlanta, Georgia, suggests that an investigational stem cell-based therapy called PEC-Direct, intended to function as a replacement pancreas, has the potential to provide blood sugar control in patients with high-risk type 1 diabetes.

The research discovered that numerous individuals receiving the new treatment showed clinically significant increases in C-peptide, a substance produced in the pancreas alongside insulin. Measuring C-peptide can reveal how much insulin the body is producing since they are both released from the pancreas at the same time and insimilar quantities.

This research represents the first instance in multiple patients of clinically relevant increases in C-peptide, indicative of insulin production, with a stem cell-based therapy delivered in a device, according to Manasi Sinha Jaiman, M.D., M.P.H., Chief Medical Officer of ViaCyte, Inc., in San Diego, Calif., the company that makes PEC-Direct.

People with type 1 diabetes gradually lose the ability to produce insulin on their own, which is necessary for blood sugar regulation. Patients must check those levels on a regular basis using finger sticks, administer repeated insulin injections, or carry around cumbersome devices. Additionally, there is a chance that the insulin injection can inadvertently drop blood sugar to unsafe levels.

The PEC-Direct device is intended to provide a consistent, long-term sourceof insulin to control blood sugar levels. The system consists of a pouch containing pancreatic cells produced from stem cells that, when implanted in the body, develop into cells that produce insulin. The devices open membrane enables blood vessels to grow into it to contact the cells. Patients use immunosuppressive drugs to prevent an immune reaction.

The treatment is meant for patients with high-risk type 1 diabetes, who may be especially vulnerable to acute complications due to factors such as recurrent severe low blood sugar, or frequent and extreme blood sugar fluctuations that are difficult to control.

The study included 10 adults with type 1 diabetes who had received their diagnosis at least 5 years prior to the start of the study and were not able to tell when their blood sugar went too low (called hypoglycemia unawareness). Initial data from one patient showed clinically relevant levels of stimulated C-peptide and corresponding improvements in blood glucose control within six months after implantation of PEC-Direct.

Since then, increased C-peptide levels were seen in multiple patients, along with decreases in HbA1C (a blood test that measures average blood sugar levels over the past three months) by as much as 1.5%, and decreases in the amount of insulin patients needed to administer by as much as 70%.

The results suggest stem cell-based replacement therapy has the potential to provide blood glucose control and could one day eliminate the need for injecting or dosing insulin externally, Jaiman said. The study provides further proof-of-concept that continued optimization of PEC-Direct has promise as a functional cure for type 1 diabetes.

Meeting: ENDO 2022

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Orchard Therapeutics Announces Multiple Presentations at 2022 SSIEM Annual Symposium Highlighting Neurometabolic Disease Portfolio – GlobeNewswire

Posted: August 30, 2022 at 2:46 am

BOSTON and LONDON, Aug. 29, 2022 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX), a global gene therapy leader, today announced seven presentations from across its neurometabolic portfolio will be featured at the Society for the Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium, taking place from August 30 to September 2, 2022, in Freiburg, Germany.

Featured presentations include an oral presentation on Libmeldy (atidarsagene autotemcel) from clinical development through approval by the European Commission and treatment of the first patients in a commercial setting in Europe, several accepted abstracts highlighting newborn screening efforts to support the timely and accurate diagnosis of metachromatic leukodystrophy (MLD), as well as an encore clinical data presentation from the companys investigational hematopoietic stem cell (HSC) gene therapy OTL-203 for MPS-IH.

The oral presentation details are as follows:

The poster presentation details are as follows:

About Libmeldy / OTL-200Libmeldy (atidarsagene autotemcel), also known as OTL-200, has been approved by the European Commission for the treatment of MLD in eligible early-onset patients characterized by biallelic mutations in the ARSA gene leading to a reduction of the ARSA enzymatic activity in children with i) late infantile or early juvenile forms, without clinical manifestations of the disease, or ii) the early juvenile form, with early clinical manifestations of the disease, who still have the ability to walk independently and before the onset of cognitive decline. Libmeldy is the first therapy approved for eligible patients with early-onset MLD.

The most common adverse reaction attributed to treatment with Libmeldy was the occurrence of anti-ARSA antibodies. In addition to the risks associated with the gene therapy, treatment with Libmeldy is preceded by other medical interventions, namely bone marrow harvest or peripheral blood mobilization and apheresis, followed by myeloablative conditioning, which carry their own risks. During the clinical studies of Libmeldy, the safety profiles of these interventions were consistent with their known safety and tolerability.

For more information about Libmeldy, please see the Summary of Product Characteristics (SmPC) available on the EMA website.

Libmeldy is approved in the European Union, UK, Iceland, Liechtenstein and Norway. OTL-200 is an investigational therapy in the U.S.

Libmeldy was developed in partnership with the San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget) in Milan, Italy.

About Orchard TherapeuticsAt Orchard Therapeutics, our vision is to end the devastation caused by genetic and other severe diseases. We aim to do this by discovering, developing and commercializing new treatments that tap into the curative potential of hematopoietic stem cell (HSC) gene therapy. In this approach, a patients own blood stem cells are genetically modified outside of the body and then reinserted, with the goal of correcting the underlying cause of disease in a single treatment.

In 2018, the company acquired GSKs rare disease gene therapy portfolio, which originated from a pioneering collaboration between GSK and the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy. Today, Orchard is advancing a pipeline spanning pre-clinical, clinical and commercial stage HSC gene therapies designed to address serious diseases where the burden is immense for patients, families and society and current treatment options are limited or do not exist.

Orchard has its global headquarters inLondonandU.S. headquarters inBoston. For more information, please visitwww.orchard-tx.com, and follow us onTwitterandLinkedIn.

Availability of Other Information About OrchardInvestors and others should note that Orchard communicates with its investors and the public using the company website (www.orchard-tx.com), the investor relations website (ir.orchard-tx.com), and on social media (TwitterandLinkedIn), including but not limited to investor presentations and investor fact sheets,U.S. Securities and Exchange Commissionfilings, press releases, public conference calls and webcasts. The information that Orchard posts on these channels and websites could be deemed to be material information. As a result, Orchard encourages investors, the media, and others interested in Orchard to review the information that is posted on these channels, including the investor relations website, on a regular basis. This list of channels may be updated from time to time on Orchards investor relations website and may include additional social media channels. The contents of Orchards website or these channels, or any other website that may be accessed from its website or these channels, shall not be deemed incorporated by reference in any filing under the Securities Act of 1933.

Forward-looking StatementsThis press release contains forward-looking statements, which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. These statements are neither promises nor guarantees and are subject to a variety of risks and uncertainties, many of which are beyond Orchards control, which could cause actual results to differ materially from those contemplated in these forward-looking statements. Given these uncertainties, the reader is advised not to place any undue reliance on such forward-looking statements.

Other risks and uncertainties faced by Orchard include those identified under the heading "Risk Factors" in Orchards most recent annual or quarterly report filed with the U.S. Securities and Exchange Commission (SEC), as well as subsequent filings and reports filed with the SEC. The forward-looking statements contained in this press release reflect Orchards views as of the date hereof, and Orchard does not assume and specifically disclaims any obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as may be required by law.

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