Page 264«..1020..263264265266..270280..»

Brigham and Womens researchers say diabetes drug helps reduce heart failure – The Boston Globe

Posted: August 30, 2022 at 2:58 am

A blockbuster diabetes drug significantly reduced the risk of hospitalization and death in people with all types of heart failure, according to a large international study led by a researcher at Brigham and Womens Hospital.

The clinical trial found that AstraZenecas drug Farxiga reduced cardiovascular death or worsening heart failure by 18 percent when compared with a placebo in 6,000 patients followed for a median of 2.3 years in 20 countries. Farxiga was first approved in 2014 for the treatment of type 2 diabetes and generated $1 billion in quarterly sales in the first three months of 2022.

Dr. Scott D. Solomon, a professor of medicine at Harvard Medical School and Brigham and Womens, and principal investigator for the study, said a separate meta-analysis he helped conduct of more than 12,000 patients confirmed that Farxiga and a rival drug called Jardiance, sold by Boehringer Ingelheim and Eli Lilly and Co., decreases the number deaths, as well as urgent trips to hospitals.

Get Innovation Beat

Boston Globe tech reporters tell the story of the region's technology and innovation industry, highlighting key players, trends, and why they matter.

We now have really very definitive evidence that regardless of what type of heart failure a patient has, they would benefit from being on this class of drugs, said Solomon. The studies were published in the New England Journal of Medicine, The Lancet, and Nature Medicine. Solomon helped present the findings at the European Society of Cardiology Congress in Barcelona over the weekend.

Heart failure, sometimes known as congestive heart failure, occurs when the heart muscle doesnt pump blood as well as it should. Blood often backs up, and fluid can build up in the lungs, causing shortness of breath, fatigue, and swelling in the legs. The condition, which becomes more common with age, is the leading cause of hospitalization in people over 65 years old, according to the US Food and Drug Administration. It affects more than 650,000 in the United States each year.

Both Farxiga and Jardiance are known as SGLT2 inhibitors and cause the body to excrete sugar in urine. For reasons not entirely understood by scientists, Solomon said, the drugs also appear to slow the progression of heart failure. And thats true for the two main groups of patients: those whose heart muscles dont contract properly, and those whose muscles contract properly but whose chambers dont relax. Both forms of the disease can diminish blood flow.

In February, the FDA allowed Jardiance, which had previously been approved for those patients whose heart muscles dont contract properly, to be prescribed to all of them. Solomon said AstraZeneca has requested similar approval for Farxiga, which is only cleared for the first subset of heart failure patients. He expected the FDA to make a decision in the first half of 2023.

Heart failure remains one of the leading causes of death worldwide with high unmet need for some 64 million people, Mene Pangalos, AstraZenecas executive vice president overseeing research and development of biopharmaceuticals, said in a statement.

Jonathan Saltzman can be reached at jonathan.saltzman@globe.com.

More here:
Brigham and Womens researchers say diabetes drug helps reduce heart failure - The Boston Globe

Posted in Diabetes | Comments Off on Brigham and Womens researchers say diabetes drug helps reduce heart failure – The Boston Globe

Diabetes Mellitus, HCC Linked to Liver-Related Mortality in HCV Patients – MD Magazine

Posted: August 30, 2022 at 2:58 am

Investigators have identified at least 2 new risk factors for liver-related mortality in patients with hepatitis C virus (HCV).

A team, led by Nobuhiro Hattori, Department of Internal Medicine, Division of Gastroenterology and Hepatology, St. Marianna University School of Medicine, identified the risk factors linked to liver-related and non-liver-related mortality in patients with HCV following sustained virologic response to direct-acting antiviral agents.

In the retrospective, single-center cohort, the investigators examined 330 patients with HCV cured by DAAs. There was a median follow-up of 3.38 years. Each patient was administered IFN-free DAA treatment between September 2014 and January 2021 at the St. Marianna University Hospital. In addition, the patients with a history of hepatocellular carcinoma (HCC) did not have active HCC at the time of initiation of their final DAA therapy.

The study included 1481 person-years of follow-up, with 25 patients dying during the course of the study.

The investigators also collected data on age, sex, HCV genotype, history of HCC, previous DAA treatment, diabetes mellitus (DM), and hypertension history.

The team also collected laboratory test results, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total bilirubin, platelet, alpha-fetoprotein (AFP), and mac-2 binding protein glycan isomer (M2BPGi) before the final DAA treatment and at 12weeks after the end of treatment.

The investigators sought primary outcomes of the incidence and predictors of liver-related and non-liver-related deaths of patients with HCV cured by IFN-free DAA treatment.

They also identified the cumulative all-cause, liver-related, and non-liver-related mortality using Kaplan-Meier methods and univariate and multivariate Cox proportional hazard models to identify the predictors of liver-related and non-liver-related deaths.

The results show a cumulative liver-related or non-liver-related mortality rate of 0.00 or 1.29% at year 1, compared to 2.87 or 3.60% at year 3 and 5.10 or 9.46% at year 5.

For liver-related deaths, 90% (n = 9) were from liver cancer, while the most common cause of non-liver-related deaths was malignancy.

After conducting a multivariate analysis using the Cox proportional hazard model, the investigators found diabetes mellitus (HR, 13.1; 95% CI, 2.8161.3) and a history of hepatocellular carcinoma (HR, 12.8; 95% CI, 2.7659.2), independently predicted liver-related death. There were no variables linked to non-liver-related death.

Our findings suggest that DM and a history of HCC are risk factors for liver-related mortality of HCV patients cured by DAAs, the authors wrote. These results indicate that early management of HCV and HCC surveillance of diabetic patients after SVR are important to increase the chance of survival. Further studies are needed to confirm the association of DM and HCC history with survival.

The study, Risk factors for liver-related mortality of patients with hepatitis C virus after sustained virologic response to direct-acting antiviral agents, was published online in JGH Open.

Follow this link:
Diabetes Mellitus, HCC Linked to Liver-Related Mortality in HCV Patients - MD Magazine

Posted in Diabetes | Comments Off on Diabetes Mellitus, HCC Linked to Liver-Related Mortality in HCV Patients – MD Magazine

Diabetes: Signs that your blood glucose levels are too low – Hindustan Times

Posted: August 30, 2022 at 2:58 am

Controlling blood sugar levels is important for people with diabetes to avoid health complications. While persistent high blood sugar levels (hyperglycaemia) can affect your heart, nerves, kidney over a period of time, low glucose levels (hypoglycaemia) on the other hand can cause confusion, dizziness and even coma or death. If your blood sugar is lower that 70 mg/dl, then you must immediately take steps to correct it. If your blood glucose levels fall too low, there will be telltale signs from intense hunger, feeling of anxiety, mood changes, difficulty in concentration and clumsiness. (Also read: Are you at risk of diabetes? Factors that increase your chances of getting the disease)

In case you are experiencing low sugar levels, you can quickly have a simple sugar source, such as glucose tablets, hard candy or fruit juice. If you are feeling confusion or dizziness, you must immediately inform your friends or family members.

"As a person living with diabetes, you know how important it is to reduce blood sugar when it is too high, a phenomenon called hyperglycaemia. But blood sugar that is too low, or hypoglycaemias, is equally critical to avoid This decrease in blood sugar levels can cause both short-term complications, like confusion and dizziness, as well as more serious issues, including seizures, coma," writes Karishma Shah, nutritionist and wellness expert in her recent Instagram post.

Shah also talked about signs of low blood sugar levels in her post.

1. Ravenous hunger

If you suddenly, inexplicably feel as if you are starving your body is signalling that it's experiencing a blood sugar drop. A good starting point is to eat between 15 & 20 grams (g) of carbohydrates with each snack and between 40 and 65 gm at each meal.

2. Feeling of anxiety

When glucose levels fall too low your body releases the hormones epinephrine (also called adrenaline) and cortisol which signals the liver to release more sugar into the blood. This can lead to anxiety and its associated symptoms.

3. Emotional instability

Mood swings and sudden emotional episodes not typical of your normal behaviour are among the neurological symptoms of hypoglycaemia and can include irritability, stubbornness, and feelings of depression.

4. Difficulty concentrating

The brain relies on blood sugar for energy, so if there's a drop in glucose, your brain may not function properly. That can make it difficult to concentrate on one thing at a time.

5. Slurred speech and clumsiness

Your sugar-starved brain may change the way your sound. Slurred speech is a common symptom associated with blood sugar levels that drop below 40mg/dL.

Follow more stories on Facebook & Twitter

See the original post:
Diabetes: Signs that your blood glucose levels are too low - Hindustan Times

Posted in Diabetes | Comments Off on Diabetes: Signs that your blood glucose levels are too low – Hindustan Times

Touched by Type 1 Annual Conference – Educate, Encourage, and Empower all lives Touched by Type 1 Diabetes – PR Newswire

Posted: August 30, 2022 at 2:58 am

ORLANDO, Fla., Aug. 29, 2022 /PRNewswire/ -- Touched by Type 1 hosted its 5th Annual Conference on Saturday, August 27, 2022 to over 400 individuals Touched by Type 1 Diabetes at the Portofino Bay Hotel at Universal. This milestone is a major move for Touched by Type 1 on its mission to elevate awareness of Type 1 Diabetes.

"To have the ability to host a FREE, high quality day of education to those that need it most in the diabetes community, is simply a dream come true," says Elizabeth Forrest, Founder of Touched by Type 1. "For the first time ever, we provided an entire track in Spanish - something you will not find elsewhere in the type 1 diabetes world."

The 2022 Conference Featured:

The Touched by Type 1 Annual Conference is a conference for individuals of all ages and backgrounds. The goal is to educate, encourage, and empower all lives touched by Type 1 diabeteswhether they have Type 1 or a connection to someone who does. The annual conference provides the unique opportunity to be surrounded by the nation's top experts related to thriving despite diabetes.

Touched by Type 1: Elevates awareness of Type 1 Diabetes, raises funds to find a cure and inspires those with diabetes to thrive. For more information: http://www.TouchedbyType1.org.

Elizabeth ForrestTouched by Type 1407-474-4686[emailprotected]

SOURCE Touched by Type 1

Original post:
Touched by Type 1 Annual Conference - Educate, Encourage, and Empower all lives Touched by Type 1 Diabetes - PR Newswire

Posted in Diabetes | Comments Off on Touched by Type 1 Annual Conference – Educate, Encourage, and Empower all lives Touched by Type 1 Diabetes – PR Newswire

Nonprofit Blue Circle Health Partners With FQHCs on Type 1 Diabetes – Healthcare Innovation

Posted: August 30, 2022 at 2:58 am

On Sept. 1, the nonprofit Blue Circle Health will partner with up to 15 Federally Qualified Health Centers across the state of Florida to launch diabetes support coaching services while it continues to build a team and infrastructure to offer more support and care focused on Type 1 Diabetes (T1D).

In a recent blog post, Leonard DAvolio, Ph.D., Blue Circles CEO, described how in the fall of 2021, a group of T1D experts was gathered by the Leona M. and Harry B. Helmsley Charitable Trust for a two-day meeting to begin answering the question: If we could create a healthcare delivery system for people with T1D unconstrained by tradition or reimbursement concerns what would it look like? In other words, how exactly should T1D care be designed? It was the first meeting for what would become Blue Circle Health, a healthcare delivery system for people with T1D living in under-resourced communities. It is funded by the Helmsley Charitable Trust.

DAvolio said the organizations goal is to build a St. Judes-like program specifically for T1D that cares for patients regardless of their ability to pay. But he added that how exactly to do that what services to offer, where, when, and to whom introduces an enormous number of decisions, each one of which carries consequences.

He explained the decision to partner with FQHCs by mentioning that they typically focus on primary care but do not have T1D specialists on staff. Working with FQHCs will allow us to connect to the people we hope to serve while also ensuring that they have access to critically important primary care, he said.

DAvolio also noted that to become a model, one needs to be able to demonstrate not just improved outcomes but the ability to do so cost efficiently. Of all of the things we will measure, the ratio of improved outcomes to the cost of achieving improvement is among the most important, he wrote.

Blue Circle Health stresses that an important foundation for trust is a single, accessible point of contact. For this reason, our care model centers on trained diabetes support coaches. The coach serves as the primary point of contact the guide for those we serve throughout their journey. They can be accessed when theyre needed in whatever modality makes the most sense for the individual with T1D, DAvolio wrote.

Its a model learned from the ECHO Diabetes program led by Drs. Michael Haller, Ashby Walker, David Maahs and others and also informed by Dr. Michael Harris of OHSU and his NICHE program. Both proved the importance of a trained peer as a friend, mentor, and guide for supporting people with chronic conditions.

In fact, he added, the first wave of coaches will be transitioned from the Diabetes ECHO program at the University of Florida as that research project draws to a conclusion. Each of the coaches hired are from the same communities as the people Blue Circle serves, speaks the same language, and lives with T1D.

DAvolio said care would escalate from coaches to members of a multidisciplinary team that includes nurses, advanced practice nurses, registered dietitians, pharmacists, insurance navigators, behavioral health specialists, social workers, and endocrinologists with experience supporting people with T1D. In addition, connections will be made with ancillary providers through the patients primary care group to include podiatrists, optometrists and ophthalmologists, nephrologists, cardiologists, ob/gyns and others.

He also said one of the top priorities is to build an infrastructure that allows Blue Circle to gather data and learn without placing undue burden on the care team or patients. Progress to date includes access to feeds of continuous glucose monitor data from several manufacturers and validated predictive models able to anticipate dangerous situations before they become acute (e.g., rising A1c and diabetic ketoacidosis), he noted. However, there is much work to be done as todays electronic health records are designed more for billing than for learning, and few useful population health tools for people with T1D exist.

The organizations chief medical officer is Anne Peters, M.D., professor of medicine at the Keck School of Medicine of University of Southern California and director of the USC Clinical Diabetes Programs. Her research has focused on testing new approaches for diagnosing and treating diabetes and developing systems of care to improve outcomes in diabetic populations.

Prior to Blue Circle, DAvolio was the co-founder of Cyft, a company dedicated to helping serious illness care providers succeed in value-based care. He is also an assistant professor at Brigham and Womens Hospital and Harvard Medical School. He is an advisor to several healthcare startups. Prior to founding Cyft, he led informatics at Ariadne Labs where he helped improve childbirth across 70 clinics in India. Prior to that he created the infrastructure for the worlds largest genomic medicine cohort and embedded the first clinical trial within an electronic medical record system for the Department of Veterans Affairs.

Go here to see the original:
Nonprofit Blue Circle Health Partners With FQHCs on Type 1 Diabetes - Healthcare Innovation

Posted in Diabetes | Comments Off on Nonprofit Blue Circle Health Partners With FQHCs on Type 1 Diabetes – Healthcare Innovation

A Study of the Peripheral Vessels in Patients With Type 2 Diabetes Mellitus With or Without Foot Involvement – Cureus

Posted: August 30, 2022 at 2:58 am

Peripheral vascular disease (PVD) is chronic limb ischemia caused by atherosclerosis of the peripheral arteries. Diabetes mellitus (DM) is a risk factor for this disease. The probability of a diabetic foot ulcer (DFU) is higher in a patient with DM and PVD than in a patient without DM. Ankle-brachial-pressure index (ABPI) allows the measurement of blood flow towards the distal extremities, which could help timely diagnosis, initiate brief therapy, and minimize the risk of critical limb ischemia and loss. This study aims to determine the prevalence of peripheral vascular disease and assess its association with intima-media thickness (IMT) in diabetic patients with and without foot ulcers in India. In the present study, we included all type 2 DM patients. The assessment was conducted clinically by measuring Ankle Brachial Pressure Index (ABPI) radiologically by Duplex Ultrasonography (Samsung HS 70A machine), and Doppler (Linear probe- LA3 - 12A) and IMT were detected. In healthy adults, IMT ranges from 0.25 to 1.5mm, and values above 1.0mm are often considered abnormal and linked with atherosclerosis and significantly increased cardiovascular disease (CVD). In this study, 72 patients with DM were enrolled over the study period; 52 patients presented with DFU, and 20 presented without DFU. The prevalence of PVD was higher in males compared to females; 40% of the patient population in the age range of 40-49 years was with PVD, and 62.5% of patients with PVD showed an IMT value more than 1.0mm, whereas only 5% patients without PVD shows IMT value more than 1.0mm. In conclusion, among type 2 diabetic subjects, the prevalence of PVD is 72.2%, and IMT is strongly associated with PVD.

Diabetes Mellitus (DM) is a chronic, metabolic disease characterized by increased levels of blood glucose, which result from absolute or relative insulin deficiency in circumstances with -cell dysfunction, insulin resistance, or both[1]. It is one of the most usual and rapidly growing diseases worldwide. Diabetes is fast becoming a potential epidemic in India, with 77 million patients[2]and the vast majority still undiagnosed.

Diabetic footis a condition in which foot ulcers form in patients with DM[3]. It is a frightening disorder with extended hospitalization and expensive with chances of an amputated extremity[4]. However, it is possible to prevent amputation using educational and care strategies[5]. Diabetic foot is characterized by a classical triad of neuropathy, ischemia, and infection[4]. The risk of a person with DM having a DFU has been reported to be as high as 25%. Diabetic foot is the most frequent cause (about 30%) of hospitalization in patients with DM[2]. 15-20% of patients with such DFU require an amputation. Nearly 85% of the amputations are preceded due to DFU. Several elements for developing DFU have been proposed, the significant being peripheral sensory neuropathy followed by peripheral vascular disease (PVD).

PVD is chronic limb ischemia which is always generated by atherosclerosis of the peripheral veins. PVD is one of Type II DM's most common macrovascular complications[6]. Prevalence increases with age, about 3% in people below 60 years of age, and rises to over 20% in people over 75. Only a quarter of people with PVD are symptomatic. Apart from age, other risk factors include smoking, diabetes mellitus, hypertension, physical inactivity, and obesity. PVD is a disease affecting the veins supplying the legs, feet, kidneys, and intestines. PVD is typically more severe in patients with diabetes than in comparable nondiabetic individuals and is associated with a worse prognosis[7,8]. Patients with PVD risk myocardial infarction, stroke, and mortality[9,10]. Early detection of vascular changes helps effectively handle DM and DM complications.

The diagnosis technique further affects the magnitude of PVD[7]. A more precise assessment of PVD in DM must depend on a validated and reproducible diagnosis technique. Such a test includes the ankle-brachial index (ABI). The ABPI is the ratio of the ankle to systolic brachial pressure. It is suggested to be calculated by dividing the higher systolic pressure of the dorsalis pedis and tibialis posterior vessels at the ankle by the higher systolic pressures measured in the brachial vein[11]. ABPI is a simple and noninvasive technique. The ABPI showed to be more accurate and verified against angiographically confirmed disease and found to be 95% sensitive and nearly 100% specific[12].

There is a need for a structured evaluation of PVD in all DM patients. The information can help prepare protocols for the effective management of DM patients to limit morbidity. The present study aims to determine the prevalence of peripheral vascular disease and assess its association with ankle-brachial index in diabetic patients with and without foot ulcers in India.

A retrospective study was carried out on 72 consecutive patients with type 2 DM attending the medicine outpatient department/ward. Endocrine outpatient department/ward and diabetic foot clinic of SCB Medical College and Hospital, Bhubhaneshwar, between 2011 to 2012, as the patients were monitored for changes observed under the same categories for 10 years. All patients with type 2 diabetes mellitus were included in the study, and the patients with trauma, Buerger disease, fibromuscular dysplasia, or vasculitis were excluded. Ethical approval was obtained from the SCB Medical College Ethics Committee (1536/IEC/ SCBMCH/2022).

A detailed general, systemic, and foot examination of patients was done. The body mass index (BMI) was calculated using the formula: weight (kg)/height (m2). A fasting blood sugar (FBS), postprandial blood sugar (PPBS), hemoglobin [R1] (HB), cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and IMT were measured. Intima medial thickness of the popliteal vein is predictive of peripheral vascular disease, which can be detected using ABPI. ABPI was measured radiologically by Duplex Ultrasonography using an ACUSON 128 P/10 machine with a 7.5 MHz linear superficial array probe in B- mode. B-scan was used for detecting IMT, pulse wave signal for flow velocity, and color flow for site determination.

The statistical analysis of all mentioned clinical parameters was performed. The continuous variables are expressed as mean standard deviation (SD). A comparison of variables was performed using ANOVA tests. Variables with a P-value < 0.05 was considered as the level of significance.

Table1shows the demographic factors of patients (n=72) enrolled in this study. Of the total patients, it was found that 73.1% are males and 26.9% are females with PVD, whereas 60% are males and 40% are females without PVD. Age distribution was shown in table1, and here we found 40.4% of patients falling in the 40-49 years of age group are found with PVD, and 45% of patients in the age group of 50-59 years are found without PVD. In the case of the distribution of BMI, 73.1% are in the range of 18.5- 22.9 with PVD, and 70% are in the range of 18.5- 22.9 without PVD.

Out of the total patient population, 40% was in the age range of 40-49 years for patients with PVD, whereas 45% was in the age range of 50-59 years for patients without PVD. A graphical representation of the age distribution is shown in Figures1, 2.

The result of statistical analysis data, i.e., mean, standard deviation, and range for demographic, clinical, and biochemical factors for patients (n= 52) with PVD, are shown in table2.

The result of statistical analysis data, i.e., mean, standard deviation, and range for demographic, clinical, and biochemical factors for patients (n= 20) without PVD, is shown in table3.

The statistical comparison of clinical and biochemical characteristics of the study groups with PVD (n = 52) and without PVD (n =20) are shown in Table 4.

As per table4, the mean IMT in subjects with PVD (n = 52) was 1.12 .19mm (right) and 1.09 .18mm (left) whereas in subjects without PVD (n = 20), it 0.70 0.17mm (right) and 0.71 0.17mm (left). Values of HBA1c (p-value = 0.0001), Cholesterol (p value= 0.004), VLDL (p value= 0.0031) and IMT (p value=0.001) show significance. The distribution of IMT results in patients with PVD and without PVD is shown in table5.

The true magnitude of PVD in DM patients is challenging to measure as many patients can be asymptomatic, and some do not report their symptoms. ABPI is an excellent initial screening tool for the assessment of PVD. This study aimed to determine the prevalence of peripheral vascular disease and assess its association with ankle-brachial index in diabetic patients with and without foot ulcers in India. It was reported that DM patients with evidence of systemic atherosclerosis were found to be at risk for PVD. The prevalence of diabetes mellitus in India is 8.8% (among people between 20-79 years of age). The actual prevalence of PVD in people with DM is challenging to calculate, as most cases are asymptomatic and many cases refrain from reporting the symptoms. DFUs were found in 4.54% of patients newly diagnosed with type 2 diabetes mellitus in India[2]. Earlier estimations for the magnitude of PVD among DM subjects in the United States and Europe vary from 9.5-42%. In contrast, for the Asian region, the magnitude of DM populations has been reported to be lower than that in the western community[10].

In the present study, 72 persons with diabetes were enrolled over the study period; 52 patients presented with DFUs, and 20 patients were without DFUs. In this study, the prevalence of PVD in DM subjects was found to be 72.22%, with 52 out of 72 patients showing the presence of PVD. As reported earlier by Pradeepa R et al.[10], the prevalence of PVD is higher in DM subjects than in non-DM subjects in population-based and clinic-based studies.

The prevalence of PVD, symptomatic and asymptomatic, is higher in males than in females in this study. It was found in this study that gender-wise distribution indicates 73% of males and 27% of females with PVD, whereas 60% was male and 40% was female without PVD. Thus the magnitude of PVD in DM patients was higher in males than in females. These results contrast with Pradeepa R et al.[10], where female subjects were more likely to have PVD than male subjects.

The age-wise distribution shows that 40% of the patient population was in the age range of 40-49 years for patients with PVD, whereas 45% was in the age range of 50-59 years for patients without PVD. Like Ikem R et al.[7], age showed statistical significance in PVD risk in the present study.

The ABPI assessment was done radiologically by Duplex Ultrasonography which determines IMT. The normal IMT value ranges from 0.25 to 1.5mm in healthy adults, and values above 1.0mm are often considered abnormal[13]and are linked with atherosclerosis and increased cardiovascular disease. In present study, 62.5% patients with PVD shows IMT value more than 1.0mm, 36.5% patients shows IMT value in between 0.7- 1.0mm and 1.9% patients show IMT value below 0.7mm. In this study, 5% of patients without PVD showed an IMT value of more than 1.0mm, 60% of patients showed an IMT value between 0.7- 1.0mm, and 35% of patients showed an IMT value below 0.7mm. That means IMT is strongly associated with PVD.

The PVD prevalence is symptomatic and asymptomatic, and it is more in males than in females in this study. It is thus essential to investigate the presence of PVD in asymptomatic cases to manage the risk elements as early as possible and minimize mortality. We recommend screening for PVD while on the time of detection of DM for both timely detection and to prevent the disease.

This study concluded that type 2 diabetes patients with IMT of more than 1.0mm, increased CVD, and diabetic foot ulcers were prone to more risks of peripheral vascular disease. It also revealed that these risks increased gradually with the increase of age. This study revealed that males tend to have more risk of PVD than females. Detection of peripheral vascular disease in diabetic foot patients using Duplex Ultrasonography and ABPI together with regular clinical analysis will help to assist timely detection of critical extremities. The patients may not all be symptomatic or show clear signs of PVD though they need to be examined for the presence of PVD. The current and earlier studies have repeatedly manifested the need and advantages of investigating DM for peripheral ischemia to give better care. The care of DM subjects must be initiated with preventive actions, which is the key to avoiding further complications.

More here:
A Study of the Peripheral Vessels in Patients With Type 2 Diabetes Mellitus With or Without Foot Involvement - Cureus

Posted in Diabetes | Comments Off on A Study of the Peripheral Vessels in Patients With Type 2 Diabetes Mellitus With or Without Foot Involvement – Cureus

Men at The Emeline: how preventative medical care can help keep you on track – Australian Jewish News

Posted: August 30, 2022 at 2:55 am

Men make up a little less than half of the population but are overrepresented when it comes to health issues. While this is a consequence of environmental factors such as work stress or lifestyle factors such as diet and alcohol consumption, theres an additional stigma that men are often busy and dont always prioritise their own health.

The highly skilled and experienced medical team at The Emeline want to transform the notion of a doctors visit being an unpleasant experience that men dread, into a positive and pleasant experience that they almost look forward to.

A new medical practice in Malvern, The Emeline not only focuses on diverse and high-quality medical care for patients, but also the power of preventative and individually tailored medical care in ensuring ones happy and healthy future.

Dr Ion Pop, a specialist general practitioner at The Emeline, has observed changes in mens attitude towards healthcare following the COVID-19 pandemic, thanks to the opportunities for reflection throughout Melbournes lockdowns.

We have actually seen a stronger focus on men being proactive when it comes to implementing positive changes in their lives in line with their goals, Dr Pop said.

Whether its losing weight, improving body strength, exercising more, eating better, drinking less alcohol or smoking less, many men have been more motivated to look after their bodies so that they can continue to do all of the things that they value, he said.

Mens health services at The Emeline are delivered by a caring and professional team who weaves evidence-based medicine with their clinical experience and patient priorities to make health decisions and implement management plans.

Among other services, gastroenterologists Dr Michael Braude and Dr Ashley Bloom consult on site to support male gut and liver health; dietitian Mr Jordan Psomopoulos has over 20 years of experience; a range of amazing psychologists in partnership with Catalyst Psychology are on offer; and Dr Pop has previously worked at a large industrial facility managing a range of occupational health concerns including asthma, COPD, musculoskeletal injuries, hearing loss, mental health concerns and WorkCover.

For specialist general practitioner Dr Daniel Lichtblau, former cricketer Shane Warnes recent passing highlighted not just the importance of heart health, but also encouraging men to feel confident in taking charge of their health.

Our bodies are in many ways like very complicated machines, and much like with our cars, if you dont service it as often as recommended it might keep working but then you could end up with a more serious problem down the track, Dr Lichtblau believes.

Simply monitoring ones health regularly and maintaining a good relationship with a doctor who knows you well can take the friction out of the process, helps to prevent medical issues from materialising and increase the chances of detecting medical conditions sooner and initiating treatment earlier.

For more information, visit emeline.com.au

Promotional feature

Get The AJN Newsletter by email and never miss our top storiesFree Sign Up

View post:
Men at The Emeline: how preventative medical care can help keep you on track - Australian Jewish News

Posted in Preventative Medicine | Comments Off on Men at The Emeline: how preventative medical care can help keep you on track – Australian Jewish News

Study: PCPs Need 26.7 Hours Per Day to Provide Recommended Care – Healthcare Innovation

Posted: August 30, 2022 at 2:55 am

According to a UChicago Medicine article from earlier this month by Devon McPhee, if primary care physicians followed national recommendation guidelines for preventative care, chronic disease care, and acute care, it would take them 26.7 hours per day to see an average number of patients, according to a new study. The study is entitled Revisiting the Time Needed to Provide Adult Primary Care, and is published in the Journal of General Internal Medicine.

The article says that The research, conducted by the University of Chicago, Johns Hopkins University, and Imperial College London, used a simulation study to compute time per patient based on data from the National Health and Nutrition Examination Survey.

The breakdown of the 26.7 hours, according to the article, is 14.1 hours/day for preventive care, 7.2 hours/day for chronic disease care, 2.2 hours/day for acute care, and 3.2 hours/day for documentation and inbox management.

Justin Porter, M.D., assistant professor of medicine at the University of Chicago and lead author of the paper was quoted in the article saying that There is this sort of disconnect between the care weve been trained to give and the constraints of a clinic workday. We have an ever-increasing set of guidelines, but clinic slots have not increased proportionately.

Further, The study also looked at physician time as part of a team, where nurses, physician assistants, counselors and others help to deliver recommended care.

It found that team-based care reduced the time a physician needed to deliver care to 9.3 hours/day, broken into 2.0 hours/day for preventive care, 3.6 hours/day for chronic disease care, 1.1 hours/day for acute care, and 2.6 hours/day for documentation and inbox management.

The article adds that a 2003 study from Duke University estimated it would take a primary care physician 7.4 hours a day to provide preventative care for an average-sized patient population. In a 2005 study from Mount Sinai, the estimated time per day was 8.6 hours.

The new study went one step further by including all types of care a primary care physician providespreventive, acute, and chronicas well as administrative tasks, and accounted for changes to the guidelines that have occurred since the earlier studies were published, the article adds. It also used a different methodology, employing real patient data from an annual national survey to calculate its results. The earlier studies used hypothetical patient populations based on the U.S. population.

Moreover, The researchers used the Comprehensive Primary Care Plus (CPC+) model to develop the estimates for team-based care. The model allows physicians to focus on advanced care and brings in specialized medical professionals to take over other areas. Dietitians, for instance, would handle nutritional counseling for patients with diabetes or obesity, a time-intensive task. Overall, the researchers determined that 65% of primary care services could be handled by other team members.

The article concludes by explaining that time constraints are a major factor in physician burnout and a main reason that medical students are leaving the field.

Read the original post:
Study: PCPs Need 26.7 Hours Per Day to Provide Recommended Care - Healthcare Innovation

Posted in Preventative Medicine | Comments Off on Study: PCPs Need 26.7 Hours Per Day to Provide Recommended Care – Healthcare Innovation

New Guidelines Target Preventing Obesity In Midlife Women, But The Conclusion Is Somewhat Controversial – Suggest

Posted: August 30, 2022 at 2:55 am

Midlife is a time of enormous change in a womans life, both good and bad. Its a time for reaching professional peaks, gaining confidence, and discovering new passions. But midlife also brings about many less-than-savory hormonal shifts, which can lead to changes in our skin, hair, and weight.

Changes to the skin and hair can be frustrating, but theyre not particularly dangerous. Weight gain, however, does pose a notable risk to a womans overall health. Obesity can increase the risk of disorders and diseases including hypertension and type 2 diabetes. It can also lead to heart disease, stroke, and all-cause mortality. Obesity has even been linked to ovarian, breast, and endometrium cancers.

A recent study published in the Annals of Internal Medicine by the Cedars-Sinai Medical Center sought to formulate new guidelines with the aim of preventing obesity in midlife. According to Kimberly D. Gregory, MD, MPH, the corresponding author of the clinical guidelines, more than two-thirds of middle-aged women are overweight or obese. Given womens increased risk for weight gain in midlife, there is a critical need for intervention aimed at preventing obesity and the host of serious health outcomes associated with it.

While the research suggests its time we start shifting the national weight guidelines, how the study reached its conclusion is somewhat controversial.

The Womens Preventive Services Initiative (WPSI) created the new obesity guidelines, which strongly encourage healthcare providers to begin addressing the issue of weight with their patients early. The WPSI guidelines suggest discussing these risks with all middle-aged women, even those who might be at a healthy weight.

This preventative treatment would involve behavioral counseling for women aged 40 to 60, which includes speaking to women about healthy eating and physical activity. These interventions, and the study itself, refer to the traditional BMI, or body mass index (more on that later).

The study included seven randomized clinical trials with over 50,000 patients aged 40 to 60. Participants went through various behavioral and counseling interventions. According to the study, trials indicated favorable weight changed with interventions that were statistically different from the control groups.

Interventions varied in intensity, frequency, and approach and, in turn, had varying degrees of effectiveness. The WPSI recognized that research studies might not answer all of the clinical questions regarding the efficacy of prevention rather than treatment. Nevertheless, this shift in perspective could be extremely positive.

RELATED: The 5 Key Health Appointments To Start Scheduling In Your 40s

Western medicine has often approached healthcare from a treatment standpoint instead of prevention. These reactive measures have made great strides in the biomedical world, including the eradication of smallpox. But after the Affordable Care Act passed in 2010, the medical world shifted toward preventative health care.

Still, its difficult to provide preventative health care when youre unsure of what, exactly, youre preventingor why. Popular health care often overlooks midlife women. Many doctors arent trained to understand perimenopause and menopause and other health issues that arise in this phase of life. If they dont fully understand females changing hormones, then how can they counter, let alone prevent, its adverse side effects?

RELATED: The Brain Drain In Real: How Women Over 40 Can Fight Brain Fog Caused By Perimenopause

This creates a cycle of frustration: a woman assumes her doctor wont understand her needs and so doesnt bother to share them. The doctor, none the wiser, continues to not treat her menopausal symptoms, either out of ignorance or lack of experience.

A shift toward preventative care could flip this narrative. Preventive care promotes research and proactive thinking instead of problem-solving and troubleshooting. According to the Mayo Clinic, there can be many contributing factors to midlife weight gain, both lifestyle and genetic. A preventative approach to treatment seeks to mitigate these causal factors before they do significant damage.

In theory, the study sounds positive. However, many critics hesitate to use BMI to measure health. Not only was BMI originally used to describe entire populations, not individuals, but its based on a white European man as the average, which is decidedly unhelpful for American women of all races and ethnicities.

Consequently, the inaccuracies of BMI can put people at risk of being over or underdiagnosed for certain conditions. Today, traditional BMI classifies anything between 18.5 and 25 as a healthy weight. The index considers 25-30 as overweight and over 30 as obese.

But depending on your genetics and ethnicity, BMI will not always capture an accurate picture of your health. This can lead to distortion of health assessments and increases the risk of developing a negative body image. Moreover, BMI-specific treatment could produce little to no significant results.

Therefore, its critical to find an OBGYN or PCP who takes your personal history into account. Preventative treatment for obesity can certainly be beneficial to all body types and sizes, not just those who are currently overweight, but until western healthcare starts acknowledging each patients unique background, we still have a long way to go.

Original post:
New Guidelines Target Preventing Obesity In Midlife Women, But The Conclusion Is Somewhat Controversial - Suggest

Posted in Preventative Medicine | Comments Off on New Guidelines Target Preventing Obesity In Midlife Women, But The Conclusion Is Somewhat Controversial – Suggest

Colleges need to prepare for monkeypox to spread among students, infectious disease experts say – PhillyVoice.com

Posted: August 30, 2022 at 2:54 am

College students are heading back to campus for the first time since the monkeypox outbreak gained traction in the United States, and many health experts say their schools need to develop plans for handling potential cases.

Several schools, including West Chester and Bucknell universities in Pennsylvania, experienced cases earlier this summer. More monkeypox infectionsare a possibility given that college students commonly engage in many activities that involve skin-to-skin contact, including sex, dancing and contact sports, experts say.

Schools need to prepare strategies similar to those they implemented in response to COVID-19, experts say. That includes testing, contact tracing and clear communication on preventive measures and how students should respond if they become symptomatic.

Dr. Brett C. Gilbert, chief of the Division of Infectious Diseases and Preventative Medicine at Main Line Health, said it's possible that monkeypox could spread on college campuses this fall.

"The prevalence and severity are unknown at this time," he cautioned. "There should be appropriate infection control policies put in place at college infirmaries."

Dr. Martin Topiel, chief of infectious disease prevention at Virtua Health, said he doesn't think monkeypox will be a major problem on college campuses, but he said people who are sexually active need to take precautions.

Monkeypox is not a sexually transmitted disease, but it primarily spreads through close skin-to-skin contact, including during sex, hugging and kissing. It also can spread through contact with an infected person's bedding and other fabrics.

People should alert their sexual partners about any lesions or rashes they may have and avoid intimate contact with anyone who has them, Topiel said. And though this monkeypox outbreak has mostly spread among men who have sex with men, transmission is possible among anyone.

Though monkeypox also can spread through respiratory secretions, that's not viewed as a common source of transmission unlike more airborne-dependent illnesses, like COVID-19.

"While there is some concern about respiratory secretions, it appears it takes a long duration about 3 hours or more for someone to be infected," Topiel said.

Colleges need to focus on public health awareness, Topiel said. That includes educating students about how to protect themselves from infection and promoting vaccination for people considered at high risk.

Philadelphia health officials "expect there to be some level of spread to colleges and universities," said Matthew Rankin, a spokesperson for the Department of Public Health.Through Monday,Phillyhad recorded 257 monkeypox cases since the outbreak began.

"Currently, the monkeypox virus seems to have been limited to specific social networks," Rankin said. "At this time, we have not seen advancement of spread to the city at large. However, we do expect to see spread outside of these communities and possibly into colleges and universities," Rankin said.

Rankin said college students should take the same precautions as everyday residents:

"We know that this particular virus spreads in a couple specific ways," Rankin said. "It is important to know this disease does not spread through casual contact. It is spread through direct skin-to-skin contact or prolonged face-to-face interaction."

The U.S. Centers for Disease Control and Prevention has not released any specific monkeypox guidelines for college campuses. However, it has issued recommendations for congregate settings. They include:

The American College Health Associationreportedlyis working on drafting best practices for preventing and containing monkeypox infections on college campuses. Many schools in the Philadelphia region have begun preparing for potential cases, including the possibility that infected students will need to isolate.

West Chester University is finalizing its monkeypox protocols for the fall semester with the help of the Chester County Health Department and the CDC, spokesperson Nancy Santos Gainer said.

The university's student health services has monkeypox test kits on hand and is prepared to answer students' questions and provide testing, if needed, Gainer said. Comprehensive educational information, including FAQs, will be included on its website. The Chester County Health Department also will be conducting collaborative training with student health services and different on-campus groups.

"When the vaccine becomes available for the university to access, there has been talk with the Chester County Health Department about the university's willingness to provide the vaccine on a voluntary basis," Gainer added. "The university is committed to following the guidance of the Chester County Health Department and the CDC, and have students self-isolate should they contract monkeypox."

Temple University is focused on educating students, testing people with symptoms and helping high-risk people get vaccinated.Thomas Trojian, assistant clinical director at Temple's Student Health Services, emphasized that monkeypox can be spread as soon as a person develops a fever, feels unwell or has a rash or lesions. Infected people can continue to spread monkeypox until the lesions have scabbed over, fallen off and new skin has grown back.

The University of Pennsylvania is working with health agencies to "continually assess" the risk monkeypox poses to the university community and access to vaccines and treatments, spokesperson Mary Kate Coghlan said. "Risk on campus remains extremely low," Coghlan added.

AtLa Salle University, Assistant Vice President of Student Wellness Scott Cook sent out a message linking to campus resources and preventative information.

Holy Family University is "preparing an education and awareness campaign to ensure that students and the broader community are armed with the information they need to prepare, prevent, and stay safe," spokesperson Sherrie A. Madia said.

The U.S. declared monkeypox a public health emergency earlier this month. As of Tuesday, there were 15,433 confirmed cases in U.S., including 422 in Pennsylvania and 420 in New Jersey, according to theCDC.

In previous monkeypox outbreaks, the spread of the virus was very limited. Scientists are trying to determine why it has spread more broadly during this outbreak. They believe the virus hasn't changed, nor has the way it moves from host to host.

In West and Central Africa, where the virus has been endemic for decades, a single case or small cluster occasionally occur, primarily among hunters and people who handle or are bitten by infected animals. But it rarely spread widely within communities. In this outbreak, scientists believe the social networks the virus has found may be helping it spread more widely.

The good news, infectious disease experts say, is that monkeypox is not good at infecting humans, so it requires high amounts of the virus for a person to become infected. The three most common ways to contract the virus are direct skin-to-skin contact with a lesion, touching contaminated objects and close contact with respiratory secretions, like saliva from a person with lesions in the mouth or throat.

It remains unclear whether urine, feces, blood, semen or vaginal fluids can spread the virus and whether asymptomatic people can still infect others. It is also not clear how big a role inhaled respiratory particles may be playing in the latest outbreak.

Go here to read the rest:
Colleges need to prepare for monkeypox to spread among students, infectious disease experts say - PhillyVoice.com

Posted in Preventative Medicine | Comments Off on Colleges need to prepare for monkeypox to spread among students, infectious disease experts say – PhillyVoice.com

Page 264«..1020..263264265266..270280..»