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Lifesaving stem cell treatments must be offered in Ireland, says expert

Posted: April 19, 2012 at 12:11 pm

Lifesaving stem cell treatments must be offered in Ireland, says expert

By Sen McCrthaigh

Thursday, April 19, 2012

Ireland is seriously lagging behind most other countries in offering live-saving treatments provided by the use of adult stem cells, a leading international medical expert has warned.

Colin McGuckin called on the Government and health authorities to facilitate the wider collection and storage of stem cells from umbilical cord blood in Ireland.

Prof McGuckin who is advisor to the Vatican on stem cells and a director of the Cell Therapy Research Institute in Lyon, France is director of the Adult Stem Cell Foundation of Ireland, which was formally launched yesterday.

"Treatments which are available in other countries must come to Ireland," said Mr McGuckin. He also expressed fears the lack of stem cell therapies here could force people to seek unregulated care abroad.

Presently, none of Irelands three main maternity hospitals allow for the collection of adult stem cells from umbilical cords except in high-risk cases.

The only facility which allows the practice is Mount Carmel Hospital in Dublin. All adult stem cells collected are sent abroad for storage.

Mr McGuckin said adult stem cells could be used in the treatment of over 70 diseases including leukaemia and heart disease. Advances are also being made in their use for neurological diseases such as Alzheimers.

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Baldness Cure: Japanese Study Finds Stem Cells Induce Hair Regrowth for Bald Heads on Mouse [PHOTO & VIDEO]

Posted: April 19, 2012 at 12:10 pm

From Rogaine to hair plugs, there have been many strides made to induce hair regrowth for bald or balding heads, but a new Japanese study found a possible cure to baldness by using stem cells.

Using stem cell therapy, scientists at the Tokyo University of Science in Japan led by Takashi Tsuki gave a hairless mouse a Mohawk by regenerating hair follicles.

Researchers used follicles from a normal mouse, namely adult epithelial stem cells and dermal papilla cell found in the skin, to create a "seed" of a hair follicle. Then, they implanted the newly-created "seed" using intracutaneous transplantation into the hairless mouse and -- Voila! -- hair.

According to the research published in Nature Communications, functional hair follicles grew on the hairless mouse properly on the skin in the epidermis, arrector pili muscle and nerve fibers. The newly regrown hair also went through a standard hair cycle of shedding and regrowth.

"Our current study thus demonstrates the potential for not only hair regeneration therapy but also the realisation of bioengineered organ replacement using adult somatic stem cells," the report said.

The baldness cure that worked on the hairless mice, however, has not yet been tested on humans, but the researchers hope to introduce the idea soon.

"We would like to start clinical research within three to five years, so that an actual treatment to general patients can start within a decade," researcher Koh-ei Toyoshima said in a statement.

However, even if it does work on people, the issue is raised about the cost, as stem cell therapy practices can be quite costly.

View the video of the hairless mouse with hair regrowth below.

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Baldness Cure: Japanese Study Finds Stem Cells Induce Hair Regrowth for Bald Heads on Mouse [PHOTO & VIDEO]

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State: Grekos extracted tissue from stem cell patient who died, damaged patient's abdomen

Posted: April 19, 2012 at 12:10 pm

Photo by Allie Garza

Dr. Zannos Grekos, a cardiologist whose practice is in Bonita Springs, speaks with a seminar attendant after one of his educational seminars about stem cell treatment, using one's own stem cells, for treating heart disease and other medical conditions, on Monday, March 14, 2011, at the Collier County Library. Allie Garza/Staff

K.K.Yankopolus

In a case involving a criminal investigation into the recent death of a 77-year-old man after stem cell treatment, state health authorities say Dr. Zannos Grekos extracted tissue from the patient while a second doctor later injected the patient with his own concentrated stem cells.

But when Grekos, a Bonita Springs cardiologist, initially harvested fatty tissue from Richard Poling's stomach on March 2, he unknowingly damaged the patient's abdomen which led to bleeding, according to a state Department of Health complaint.

New documents obtained by the Daily News shed more light on the case of Grekos and Dr. Konstantine Yankopolus, a Fort Myers obstetrician who assisted Grekos. They face potential disciplinary action from the state Board of Medicine for doing a stem cell treatment that the state says was experimental and dangerous.

The state issued separate administrative complaints against them in late March and early April, a few weeks after Poling died the same day of the treatment. He suffered a cardiac arrest in Grekos' practice on Bonita Beach Road and was pronounced dead at NCH North Naples Hospital.

The Lee County Sheriff's Office launched a criminal investigation in early March and it is ongoing, agency spokesman Larry King said.

Grekos also faces potential discipline when the state restricted his license in February, 2011 in connection to the death of a 69-year-old woman who went to him in 2010 for stem cell therapy.

She sought a remedy for neurological damage after chemotherapy for breast cancer. She fell in her home after the treatment, suffered a brain injury and later was taken off life support.

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State: Grekos extracted tissue from stem cell patient who died, damaged patient's abdomen

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Hair regeneration from adult stem cells

Posted: April 18, 2012 at 7:11 pm

ScienceDaily (Apr. 18, 2012) Research group headed by Professor Takashi Tsuji demonstrates regenerating "functional hair regeneration from adult stem cells" Substantial advance in the development of next-generation of "organ replacement regenerative therapies"

Organ replacement regenerative therapy is purported to enable the replacement of organs damaged by disease, injury or aging in the foreseeable future. A research group led by Professor Takashi Tsuji (Professor in the Research Institute for Science and Technology, Tokyo University of Science, and Director of Organ Technologies Inc.) has provided a proof-of-concept for bioengineered organ replacement as a next stage of regenerative therapy.

Reporting in Nature Communications the group demonstrate that bioengineered hair follicle germ reconstructed from adult epithelial stem cells and dermal papilla cells can regenerate fully functional hair follicle and hair growth. Their bioengineered follicles showed restored hair cycles and piloerection through the rearrangement of follicular stem cells and their niches. The bioengineered hair follicle also developed the correct structures and formed proper connections with surrounding host tissues such as the epidermis, arrector pili muscle and nerve fibers.

This study thus reveals the potential applications of adult tissue-derived follicular stem cells as a bioengineered organ replacement therapy.

This was collaborative research with Lecturer Tarou Iri and Professor emertius Tetsuhiko Tachikawa (Department of Oral Pathology, Showa University School of Dentistry, Japan), Professor Akio Sato (Department Regenerative Medicine, Plastic and Reconstructive Surgery, Kitasato University School of Medicine, Japan) and Associate Professor Akira Takeda (Department of Plastic and Aesthetic Surgery, Kitasato University School of Medicine, Japan).

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Hair regeneration from adult stem cells

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Stem Cell Therapy – T6 Spinal Cord Injury (complete) at Stem Cell Institute Panama City, Panama – Video

Posted: April 18, 2012 at 7:11 pm

16-04-2012 16:52 Spinal cord injury patient, Chris Niles, discusses his improvements after undergoing stem cell therapy at the the Stem Cell Institute in Panama City, Panama. Chris now has sensation down to about a T10 level and has regained movement in his feet.

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Stem Cell Therapy - T6 Spinal Cord Injury (complete) at Stem Cell Institute Panama City, Panama - Video

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State: Grekos extracted tissue from stem cell patient who died, damaged patient's abdomen

Posted: April 18, 2012 at 7:11 pm

Photo by Allie Garza

Dr. Zannos Grekos, a cardiologist whose practice is in Bonita Springs, speaks with a seminar attendant after one of his educational seminars about stem cell treatment, using one's own stem cells, for treating heart disease and other medical conditions, on Monday, March 14, 2011, at the Collier County Library. Allie Garza/Staff

K.K.Yankopolus

In a case involving a criminal investigation into the recent death of a 77-year-old man after stem cell treatment, state health authorities say Dr. Zannos Grekos extracted tissue from the patient while a second doctor later injected the patient with his own concentrated stem cells.

But when Grekos, a Bonita Springs cardiologist, initially harvested fatty tissue from Richard Poling's stomach on March 2, he unknowingly damaged the patient's abdomen which led to bleeding, according to a state Department of Health complaint.

New documents obtained by the Daily News shed more light on the case of Grekos and Dr. Konstantine Yankopolus, a Fort Myers obstetrician who assisted Grekos. They face potential disciplinary action from the state Board of Medicine for doing a stem cell treatment that the state says was experimental and dangerous.

The state issued separate administrative complaints against them in late March and early April, a few weeks after Poling died the same day of the treatment. He suffered a cardiac arrest in Grekos' practice on Bonita Beach Road and was pronounced dead at NCH North Naples Hospital.

The Lee County Sheriff's Office launched a criminal investigation in early March and it is ongoing, agency spokesman Larry King said.

Grekos also faces potential discipline when the state restricted his license in February, 2011 in connection to the death of a 69-year-old woman who went to him in 2010 for stem cell therapy.

She sought a remedy for neurological damage after chemotherapy for breast cancer. She fell in her home after the treatment, suffered a brain injury and later was taken off life support.

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State: Grekos extracted tissue from stem cell patient who died, damaged patient's abdomen

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Cell Surface Markers 2012: US, Europe, Japan Forecasts by Test, Market Segment and Country

Posted: April 18, 2012 at 7:11 pm

NEW YORK, April 18, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

Cell Surface Markers 2012: US, Europe, Japan Forecasts by Test, Market Segment and Country

http://www.reportlinker.com/p0365379/Cell-Surface-Markers-2012-US-Europe-Japan-Forecasts-by-Test-Market-Segment-and-Country.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic

The use of surface marker identification and classification of cells is spreading beyond lymphocytes to the identification of monocytes, macrophages, myeloid stem cells, and tumor cells. A synergistic combination of the hybridoma technology with flow cytometry is further expanding the applications of both technologies. During the next ten years, the main trend in cell surface marker analysis will be further simplification of the sample preparation and the analysis itself.

This report presents a detailed overview of the CD4, CD8 and CD34 Cell Surface Marker testing in the US, Europe (France, Germany, Italy, Spain, UK) and Japan, including clinical significance and current laboratory practice, as well as 5- and 10-year test volume forecasts by country and market segment.

The report examines market applications of monoclonal antibodies, IT, DNA probes, biochips/microarrays, and other technologies; reviews features and operating characteristics of automated analyzers; profiles leading suppliers and recent market entrants developing innovative technologies and products; and identifies alternative market penetration strategies and entry barriers/risks.

Contains 120 pages and 15 tables

Table of Contents

I. Introduction

II. Worldwide Market and Technology Overview

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Cell Surface Markers 2012: US, Europe, Japan Forecasts by Test, Market Segment and Country

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Stemlogix Selects Butler Schein Animal Health to Distribute Versatile In-Clinic Stem Cell Therapy System to …

Posted: April 18, 2012 at 7:11 pm

WESTON, Fla., April 17, 2012 (GLOBE NEWSWIRE) -- Stemlogix, a regenerative medicine company offering premier in-clinic stem cell therapy solutions to veterinarians, announced today that it has selected Butler Schein Animal Health(TM) to distribute its regenerative medicine system, stem cell therapy kits and other biological therapies. Butler Schein Animal Health(TM) - a Henry Schein Company - is the largest companion animal health distribution company in the U.S.

Based in the U.S., Stemlogix is an innovative leader in the rapidly emerging field of veterinary regenerative medicine. The Company develops and manufactures stem cell therapy kits and platelet rich plasma kits domestically according to FDA cGMP regulations. Stemlogix offers scientifically validated technologies and protocols that will enable veterinarians to provide their patients with affordable, versatile regenerative medicine solutions including adipose (fat) and bone marrow derived stem cells, platelet rich plasma (PRP) and cytokine therapies at the point-of-care, all in less than 90 minutes. The Company also offers stem cell banking and stem cell expansion services to veterinarians around the country.

Butler Schein Animal Health(TM) will now offer the Stemlogix regenerative medicine system to its network of over 26,000 veterinary clinics in the U.S., helping Stemlogix to expand its market presence across North America. "We are excited to be working with Butler Schein to offer the Stemlogix in-clinic regenerative medicine system to their vast network of veterinarians," said Kristin Comella, CEO of Stemlogix. "This partnership will enable Stemlogix to help standardize and advance the field of regenerative medicine."

Clinical research has shown that regenerative stem cell therapies have been safely and effectively used to treat degenerative diseases and acute tissue injuries including arthritis, laminitis, tendon injuries and ligament injuries. Stemlogix has developed an array of convenient, affordable, same-day regenerative therapies designed to achieve reproducible and superior clinical outcomes. Stemlogix also has developed an innovative technique to remove stem cell rich fat tissue from horses in a minimally invasive, scar-free method, called Equine VetLipo(TM).

About Stemlogix, LLC

Stemlogix is an innovative veterinary regenerative medicine company committed to providing veterinarians with the ability to deliver the best possible stem cell therapy to dogs, cats and horses at the point-of-care. Stemlogix provides veterinarians the ability to produce PRP and isolate regenerative stem cells from a patient's own fat tissue or bone marrow in their own clinic. Stemlogix is the first company to provide veterinarians with the ability to produce multiple cellular therapies using the same system and the company offers the most versatile regenerative medicine system available. Stemlogix has a full scale cGMP stem cell manufacturing facility and a scientific team with expertise in developing stem cell products, FDA compliance and clinical research. For more information about veterinary regenerative medicine please visit http://www.stemlogix.com.

About Butler Schein Animal Health(TM)

Butler Schein Animal Health (Butler Schein) -- the veterinary division of Henry Schein (Nasdaq: HSIC - News) is the leading companion animal health distribution company in the United States headquartered in Dublin, Ohio. Butler Schein employs approximately 900 team members including 300 field sales representatives and 200 telesales and customer support representatives. With 15 strategically positioned, state-of-the-art distribution facilities and 10 inside sales centers nationwide, we maintain 98%+ order-fill ratio, accomplishing our mission of providing the right product at the right place and at the right time.

Partnering with over 400 leading animal health manufacturers in the world, Butler Schein is positioned to bring the broadest selection of veterinary products and strategic solutions to veterinary professionals nationwide, including:

1.

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Stemlogix Selects Butler Schein Animal Health to Distribute Versatile In-Clinic Stem Cell Therapy System to ...

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Neural stem cell transplants for spinal cord injury maximized by combined, complimentary therapies

Posted: April 18, 2012 at 7:11 pm

Public release date: 17-Apr-2012 [ | E-mail | Share ]

Contact: David Eve celltransplantation@gmail.com Cell Transplantation Center of Excellence for Aging and Brain Repair

Tampa, Fla. (April. 17, 2012) Combined, complimentary therapies have the ability to maximize the benefits of neural stem cell (NSC) transplantation for spinal cord repair in rat models, according to a study carried out by a team of Korean researchers who published in a recent issue of Cell Transplantation (20:9), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"When transplanted, neural stem cells have demonstrated their therapeutic potential to reverse complex pathological processes following spinal cord injury," said study corresponding author Dr. Byung G. Kim of the Ajou University School of Medicine's Brain Disease Research Center and Department of Neurology, Republic of Korea. "However, many obstacles cannot be overcome by NSC transplant alone."

Their study demonstrated that a combination of treatment strategies - a polymer scaffold, neurotrophin-3 (NT3) and chondroitinase (an enzyme which helps digest the glial scar that formed after a spinal cord injury) - provided added therapeutic benefits to NSC transplantation. The implantation of a polymer scaffold designed to bridge lesion cavities, created a favorable tissue environment for nerve growth. Incorporating the NT3 gene into the transplanted cells improved cell survival and migration while the addition of chondroitinase positively affected neural activity between the scaffold and the spinal cord.

"The poly (-caprolactone) [PCL] scaffold in our study appeared to function like a reservoir supplying migratory NSCs to the spinal cord," said Dr. Kim. "The NSCs grafted with the scaffolds survived the transplantation and migrated to the host spinal cord."

The study included four animal groups, only one of which received the full combination of therapies. Rats in the full combination therapy group were found to have some restored neuroplasticity and enhanced remyelation of contralateral white matter. All four groups subsequently underwent functional testing for locomotor recovery.

"Rats in the full combination group attained well-coordinated plantar stepping accompanied by improved ankle positioning and toe clearance and reduced paw placement errors," explained Dr. Kim. "Furthermore, animals with the full complement of combination strategies responded to transcranial magnetic stimulation."

The researchers concluded that, given their success, similar treatment for humans should be carried out in a chronic injury setting.

"We believe that our results have important clinical implications regarding the future design of NSC-based therapeutic strategies for human victims of traumatic spinal cord injury," concluded Dr. Kim and co-authors.

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ETEX Corporation to Present at GTC Stem Cell Summit

Posted: April 18, 2012 at 7:11 pm

CAMBRIDGE, Mass., April 17, 2012 /PRNewswire/ --ETEX Corporation, an advanced biomaterials company, today announced two presentations at the upcoming Global Technology Community 8th Stem Cell Summit, April 19-20, 2012 at the Hyatt Harborside Hotel in Boston, MA. ETEX will highlight their cell carrier development program in two concurrent tracks: Stem Cell Commercialization & Partnering as well as Stem Cell Research & Regenerative Medicine.

(Logo: http://photos.prnewswire.com/prnh/20080424/NETH117LOGO )

Brian Ennis, President and CEO of ETEX Corporation, will deliver an oral presentation entitled "Orthobiologic Market Dynamics, Vision of the Future" during the Stem Cell Commercialization & Partnering session. Mr. Ennis will highlight key elements of a product lifecycle / replacement technology business model, outlining a new approach to skeletal repair and orthopedic innovation. This approach incorporates the combination of biomaterials and hardware, localized bone treatment with systemic therapy and stem cell delivery.

Dr. David Kaplan, Tufts University and Dr. Jerry Chang, ETEX Corporation scientific team will showcase recent advancements in their Stem Cell Carrier program during the Stem Cell Research & Regenerative Medicine session. The poster & power point presentation is entitled "Calcium Phosphate Combination Biomaterials as Human Mesenchymal Stem Cell (hMSC) Delivery Vehicles for Bone Repair".

Brian Ennis comments, "As a pioneer in growth factor and cell delivery technology, ETEX is excited to participate in this important event. We believe a cell carrier/scaffold is a grossly underestimated critical element for the successful execution of cell therapy in skeletal repair and soft tissue regeneration."

Questions regarding ETEX's participation may be directed to Jerry Chang, PhD., jchang@etexcorp.com or 617-577-7270.

About ETEX Corporation Established in 1989, ETEX Corporation develops, manufactures and commercializes calcium phosphate-based biomaterials for improved orthopedic clinical outcomes. A leader in bioresorbable bone substitute materials, ETEX focuses on expanding applications through combinations with cells, biologics, or therapeutic agents delivered in minimally invasive and easy to use systems. For more information, visit http://www.etexcorp.com.

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