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Eastday-Rejected by donor, leukemia patient saved by mother

Posted: March 31, 2012 at 6:11 am

A leukemia patient who was twice turned down by a Shanghai stem cell donor recovered from the disease after receiving her mother's half-match stem cells and a unit of umbilical cord blood from Shanghai.

Jiang Jing, a 23-year-old Jiangsu Province native, left the transplant cabin at No. 1 Hospital affiliated with Suzhou University yesterday, fully recovered.

Jiang's saga was dramatic. She was diagnosed with acute leukemia on April 1 last year and was informed by the hospital that a full match donor was found in September. The transplant was scheduled for March 6 this year.

Jiang started to undergo therapy for stem cell transplant on February 24 to suppress her immune system, paving the way for the healthy stem cells from the donor, a Shanghai university student.

However the donor backed out on March 1. She agreed a second time to give a donation on March 5 but again backed away, this time leaving the hospital secretly at midnight after receiving an injection as preparation for the donation. There were reports that the would-be donor, who was not named, faced pressure from her family to forego the procedure.

Since medication had stopped Jiang's blood-forming function on March 6, she could survive for only seven days if not undergoing transplant. Doctors decided to transplant her mother's half-match stem cells and a unit of umbilical cord blood from the Shanghai Cord Blood Bank.

The umbilical cord blood, which had an 80 percent match to Jiang, was used to reduce rejection and streamline the transplant.

Though the incident had a happy ending, it has stirred wide discussion online as some web users accused the student of putting the patient's life in danger through her actions.

But health insiders said people must have the right to change their minds.

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Your child’s milk tooth can save her life

Posted: March 31, 2012 at 6:11 am

Is your child about to lose her milk tooth? Instead of throwing it away, you can now opt to use it to harvest stem cells in a dental stem cell bank for future use in the face of serious ailments. Now thats a tooth fairy story coming to life.

Still relatively new in India, dental stem cell banking is fast gaining popularity as a more viable option over umbilical cord blood banking.

Stem cell therapy involves a kind of intervention strategy in which healthy, new cells are introduced into a damaged tissue to treat a disease or an injury.

The umbilical cord is a good source for blood-related cells, or hemaotopoietic cells, which can be used for blood-related diseases, like leukaemia (blood cancer). Having said that, blood-related disorders constitute only four percent of all diseases, Shailesh Gadre, founder and managing director of the company Stemade Biotech, said.

For the rest of the 96 percent tissue-related diseases, the tooth is a good source of mesenchymal (tissue-related) stem cells. These cells have potential application in all other tissues of the body, for instance, the brain, in case of diseases like Alzheimers and Parkinsons; the eye (corneal reconstruction), liver (cirrhosis), pancreas (diabetes), bone (fractures, reconstruction), skin and the like, he said.

Mesenchymal cells can also be used to regenerate cardiac cells.

Dental stem cell banking also has an advantage when it comes to the process of obtaining stem cells.

Obtaining stem cells from the tooth is a non-invasive procedure that requires no surgery, with little or no pain. A child, in the age group of 5-12, is any way going to lose his milk tooth. So when its a little shaky, it can be collected with hardly any discomfort, Savita Menon, a pedodontist, said.

Moreover, in a number of cases, when an adolescent needs braces, the doctor recommends that his pre-molars be removed. These can also be used as a source for stem cells. And over and above that, an adults wisdom tooth can also be used for the same purpose, Gadre added.

Therefore, unlike umbilical cord blood banking which gives one just one chance - during birth - the window of opportunity in dental stem cell banking is much bigger.

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Panel seeks funding cut over stem cell research, health insurance

Posted: March 31, 2012 at 6:11 am

Left, Michigan State University's Beaumont Tower; Right, the Michigan Union on the campus of the University of Michigan. / Courtesy MSU & JARRAD HENDERSON/Detroit Free Press

(Detroit Free Press)- Republican members of the Michigan House higher education committee flexed their muscles Friday, passing a budget recommendation that would strip state aid from Michigan's two most prominent universities over disagreements on stem cell research and mandatory student health insurance.

The Republicans have been feuding with both the University of Michigan and Michigan State University in the past year over the two social issues and has threatened to pull state aid over it.

But neither MSU or U-M blinked at the move.

"We believe there are elements in this proposal that are intended to be punitive in nature and that it would force us to raise tuition more than anticipated," said Heather Swain, MSU's vice president for university relations.

This budget recommendation, which would still have to be passed by the full committee, the full House, the Senate and eventually signed by the governor, would make good on the previous threats.

At risk is U-M's and MSU's share of nearly $40 million in performance funding, which, under the House plan, would be doled out to those universities meeting a number of criteria.

"We are, of course, disappointed that the House higher-education budget proposal restricts funding for U-M over the way the university reported its stem cell research," said U-M spokesman Rick Fitzgerald in a written statement. "The university provided a detailed report on the breadth and depth of this critical research being done on our campus. But in the weeks and months ahead we'll be focused on getting the best possible outcome for the University of Michigan."

The GOP legislators are mad at MSU because of a provision passed this year that mandates all incoming students have health insurance. If students don't certify with the university they have health insurance, they are automatically enrolled in a university-picked plan and the cost added to a student's bill.

The same legislators are upset with U-M over reporting on stem cells. In this year's state aid budget, legislators mandated that universities report on several aspects of universities embroyonic stem cell research. The only university that would have had to report that this school year would have been U-M.

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Stem cell, health insurance stances may cost U-M, MSU state aid

Posted: March 31, 2012 at 6:11 am

Republican members of the Michigan House higher education committee flexed their muscles Friday, passing a budget recommendation that would strip state aid from Michigans two most prominent universities over disagreements on stem cell research and mandatory student health insurance.

The Republicans have been feuding with both the University of Michigan and Michigan State University in the past year over the two social issues and has threatened to pull state aid over it.

But neither MSU or U-M blinked at the move.

We believe there are elements in this proposal that are intended to be punitive in nature and that it would force us to raise tuition more than anticipated, said Heather Swain, MSUs vice president for university relations.

This budget recommendation, which would still have to be passed by the full committee, the full House, the Senate and eventually signed by the governor, would make good on the previous threats.

At risk is U-Ms and MSUs share of nearly $40 million in performance funding, which, under the House plan, would be doled out to those universities meeting a number of criteria.

We are, of course, disappointed that the House higher-education budget proposal restricts funding for U-M over the way the university reported its stem cell research, said U-M spokesman Rick Fitzgerald in a written statement. The university provided a detailed report on the breadth and depth of this critical research being done on our campus. But in the weeks and months ahead well be focused on getting the best possible outcome for the University of Michigan.

The GOP legislators are mad at MSU because of a provision passed this year that mandates all incoming students have health insurance. If students dont certify with the university they have health insurance, they are automatically enrolled in a university-picked plan and the cost added to a students bill.

The same legislators are upset with U-M over reporting on stem cells. In this years state aid budget, legislators mandated that universities report on several aspects of universities embroyonic stem cell research. The only university that would have had to report that this school year would have been U-M.

U-M sent in what legislators called more than 50 pages of news releases about its stem cell research. Legislators said the numbers they wanted werent included. That led to a testy exchange earlier this month between GOP lawmakers and U-M President Mary Sue Coleman.

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Eastday-Rejected by donor, leukemia patient saved by mother

Posted: March 31, 2012 at 4:11 am

A leukemia patient who was twice turned down by a Shanghai stem cell donor recovered from the disease after receiving her mother's half-match stem cells and a unit of umbilical cord blood from Shanghai.

Jiang Jing, a 23-year-old Jiangsu Province native, left the transplant cabin at No. 1 Hospital affiliated with Suzhou University yesterday, fully recovered.

Jiang's saga was dramatic. She was diagnosed with acute leukemia on April 1 last year and was informed by the hospital that a full match donor was found in September. The transplant was scheduled for March 6 this year.

Jiang started to undergo therapy for stem cell transplant on February 24 to suppress her immune system, paving the way for the healthy stem cells from the donor, a Shanghai university student.

However the donor backed out on March 1. She agreed a second time to give a donation on March 5 but again backed away, this time leaving the hospital secretly at midnight after receiving an injection as preparation for the donation. There were reports that the would-be donor, who was not named, faced pressure from her family to forego the procedure.

Since medication had stopped Jiang's blood-forming function on March 6, she could survive for only seven days if not undergoing transplant. Doctors decided to transplant her mother's half-match stem cells and a unit of umbilical cord blood from the Shanghai Cord Blood Bank.

The umbilical cord blood, which had an 80 percent match to Jiang, was used to reduce rejection and streamline the transplant.

Though the incident had a happy ending, it has stirred wide discussion online as some web users accused the student of putting the patient's life in danger through her actions.

But health insiders said people must have the right to change their minds.

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Research and Markets: Strategic Development of Neural Stem & Progenitor Cell Products

Posted: March 31, 2012 at 4:11 am

Dublin - Research and Markets (http://www.researchandmarkets.com/research/bac5f5c5/strategic_developm) has announced the addition of the "Strategic Development of Neural Stem & Progenitor Cell Products" report to their offering.

Overview: Neurogenesis is the process by which neurons are created. This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system. These cell types include neurons, astrocytes, and oligodendrocytes. Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo.

The terms neuronal and neural also need to be defined. Technically speaking, neuronal means pertaining to neurons, and neural means pertaining to nerves, which are the cordlike bundles of fibers made up of neurons. Since both terms ultimately are descriptive of neurons, the scientific community uses the terms "neuronal" and "neural" interchangeably. The complexity of this issue is explored from a marketing perspective within this report.

In 1992, Reynolds and Weiss were the first to isolate neural stem cells from the striatal tissue of adult mice brain tissue, including the subventricular zone, which is a neurogenic area. Since then, neural progenitor and stem cells have been isolated from various areas of the adult brain, including non-neurogenic areas like the spinal cord, and from other species, including humans. During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate.

This market report focuses on recent advances in NSC research applications, explores research priorities by market segment, highlights individual labs and end-users of neuronal stem cell research products, explores the competitive environment for NSC research products, and provides 5-year growth and trend analysis. It provides detailed guidance for companies that wish to offer strategically positioned NSC research products, including cells, kits, assays, and related media and reagents.

This Market Report Includes:

- Recent advances in NSC research applications

- Research priorities by market segment

- Competitive analysis of NSC research supply companies

- Segmentation of existing NSC products

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Your child’s milk tooth can save her life

Posted: March 30, 2012 at 9:27 am

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Calcutta News.Net Friday 30th March, 2012 (IANS)

Is your child about to lose her milk tooth? Instead of throwing it away, you can now opt to use it to harvest stem cells in a dental stem cell bank for future use in the face of serious ailments. Now that's a tooth fairy story coming to life.

Still relatively new in India, dental stem cell banking is fast gaining popularity as a more viable option over umbilical cord blood banking.

Stem cell therapy involves a kind of intervention strategy in which healthy, new cells are introduced into a damaged tissue to treat a disease or an injury.

"The umbilical cord is a good source for blood-related cells, or hemaotopoietic cells, which can be used for blood-related diseases, like leukaemia (blood cancer). Having said that, blood-related disorders constitute only four percent of all diseases," Shailesh Gadre, founder and managing director of the company Stemade Biotech, told IANS.

"For the rest of the 96 percent tissue-related diseases, the tooth is a good source of mesenchymal (tissue-related) stem cells. These cells have potential application in all other tissues of the body, for instance, the brain, in case of diseases like Alzheimer's and Parkinson's; the eye (corneal reconstruction), liver (cirrhosis), pancreas (diabetes), bone (fractures, reconstruction), skin and the like," he said.

Mesenchymal cells can also be used to regenerate cardiac cells.

Dental stem cell banking also has an advantage when it comes to the process of obtaining stem cells.

"Obtaining stem cells from the tooth is a non-invasive procedure that requires no surgery, with little or no pain. A child, in the age group of 5-12, is any way going to lose his milk tooth. So when it's a little shaky, it can be collected with hardly any discomfort," Savita Menon, a pedodontist, said.

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Newly identified stem cells may hold clues to colon cancer

Posted: March 30, 2012 at 5:14 am

Public release date: 29-Mar-2012 [ | E-mail | Share ]

Contact: Melissa Marino melissa.marino@vanderbilt.edu 615-322-4747 Vanderbilt University Medical Center

Vanderbilt-Ingram Cancer Center researchers have identified a new population of intestinal stem cells that may hold clues to the origin of colorectal cancer.

This new stem cell population, reported March 30 in the journal Cell, appears to be relatively quiescent (inactive) in contrast to the recent discovery of intestinal stem cells that multiply rapidly and is marked by a protein, Lrig1, that may act as a "brake" on cell growth and proliferation.

The researchers have also developed a new and clinically relevant mouse model of colorectal cancer that investigators can now use to better understand where and how the disease arises, as well as for probing new therapeutic targets.

Colorectal cancer is the second leading cause of cancer deaths in the United States. These tumors are thought to arise from a series of mutations in intestinal stem cells, which are long-lived, self-renewing cells that gives rise to all cell types in the intestinal tract.

For more than 30 years, scientists believed that intestinal stem cells were primarily quiescent, proliferating only rarely in order to protect the tissue against cancer. Then, in 2007, researchers reported finding a population of intestinal stem cells (marked by the molecule Lgr5) that were highly proliferative.

Those findings "really changed the way we think about intestinal stem cells," said Robert Coffey, Jr., M.D., Ingram Professor of Cancer Research, co-chair of Vanderbilt's Epithelial Biology Center and senior author on the study.

"It came to so dominate the field that it raised the question about whether quiescent stem cells even existand that's where we enter into the picture."

Coffey's lab studies the epidermal growth factor (EGF) signaling pathway which includes a family of receptors known as ErbBs and its role in cancers of epithelial tissues, like the intestinal tract.

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Motor Neurone Disease Sees Stem Cell Breakthrough

Posted: March 30, 2012 at 5:14 am

Featured Article Academic Journal Main Category: Muscular Dystrophy / ALS Also Included In: Neurology / Neuroscience;Stem Cell Research Article Date: 29 Mar 2012 - 4:00 PDT

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An international team led by the UK's University of Edinburgh and King's College London, and Columbia University in New York, has for the first time made living human motor neurones that feature key properties of MND/ALS. They made the diseased nerve cells using stem cells derived from adult skin.

Having such a laboratory model of a disease to hand vastly improves the speed with which potential new drugs can be screened, and helps expand understanding of the disease.

Programme leader Dr Siddharthan Chandran, Professor of Neurology at the University of Edinburgh, and colleagues, write about this key milestone in the 26 March online, ahead of print, issue of PNAS.

Chandran said in a statement:

"Using patient stem cells to model MND in a dish offers untold possibilities for how we study the cause of this terrible disease as well as accelerating drug discovery by providing a cost effective way to test many thousands of potential treatments."

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Vatican’s Stem-Cell Censorship Sham

Posted: March 30, 2012 at 5:14 am

The Catholic Church has never had a particularly easy relationship with science. After all, this is the institution that sentenced Galileo Galilei as a heretic for his theories on the universe during the Roman Inquisition. Two thousand years later, the church forgave Galileo and called the whole misunderstanding a tragic mutual incomprehension but it remains safe to say the Vatican doesnt have a great track record when it comes to empirical open-mindedness.

So onlookers were surprised when the Vatican announced it would be hosting a global conference on the highly controversial issue of stem-cell research in Rome over four days in late April. The church held a similar conference in 2010 and 2011, which focused on its recommendation that stem-cell research should be limited to adult cells that can be harvested from live donors, not embryonic cells that destroy the source. But this years conference schedule featured some of the worlds foremost experts in embryonic research as keynote speakersleading some scientists to think that the Vatican might actually be looking for enlightenment on the topic.

That was not exactly case. Instead, the Vatican seems to have hoped that by including embryonic researchers in the program, it would appear that these scientists actually endorsed the Vaticans stance.

It might have worked to some extent, but after some of the speakers declined to censor their speeches, the Vatican abruptly canceled the conference altogether. According to the conference website, the event was canceled due to serious economic and logistic-organizational reasons that have completely jeopardized the success of the 3rd International Congress on Responsible Stem Cell Research. The scientists who were planning to attend say they are being stifled instead. I think the only interpretation is that we are being censored, Alan Trounson, president of the California Institute for Regenerative Medicine in San Francisco, said in a statement. It is very disappointing that they are unwilling to hear the truth.

Just what was the Vatican thinking? Inviting embryonic stem-cell researchers to a conference and then denying them the right to talk about their field of expertise was a major gamble. Had the speakers agreed to avoid reference to embryonic research, it would have given the disingenuous impression that they endorse the Holy Sees recommendation on adult stem-cell research only. Did the Vatican really think they could control the scientific community? Apparently so. Father Scott Borgman of the Pontifical Academy for Life, which co-organized the conference, had reportedly asked the speakers to limit their discussions to adult stem-cell research only. George Daly, a leading embryonic researcher with the Childrens Hospital in Boston, says he was actually told not to make embryonic researchhis field of expertisea focal point of his talk. When he told Borgman that he would still be touching on the topic in a historical context, higher-ups in the Vatican reportedly panicked. I had been encouraged to think that the Congress would be a forum for discussion of many areas of common interest to the Vatican and stem cell scientists, regardless of the disagreements over embryonic stem cells, Daly told The Daily Beast. We should all agree that clinical trials of new medical treatments based on stem cells should proceed according to rigorous principles to ensure patients are kept as safe as possible and free from exploitation. And we should all agree that premature claims of therapeutic efficacy and direct marketing of unproven interventions to vulnerable patients is a threat to legitimate attempts to develop experimental stem cell medicines.

Pope Benedict looks on during the mass in solemnity of the chair of St. Peter with new Cardinals in St. Peter's basilica at the Vatican on February 19, 2012. The Vatican stands by its decision to cancel the controversial conference as having a purely business motive. , Alberto Pizzoli, AFP / Getty Images

With the cancelation of the event, discourse between the two diverse entities will not have a venue. One Vatican official told the Catholic News Service that many of the Vaticans leaders were secretly glad the conference failed. I am infinitely relieved that the church has avoided a major blunder which would have confused the faithful for decades to come, the unnamed source said. The Holy Spirit has certainly shown to be present through those faithful members who drew attention to the ambiguity of the choice of speakers. I hope and pray that a review will be affected of the basis on which these congresses are planned.

Some stem-cell researchers are also relieved the conference wont go on. I personally am very uncomfortable with a scientific meeting run by a church, and one at which only certain types of science and scientists are allowed to attend, blogged Paul Knoepfler, an associate professor of Cell Biology and Human Anatomy at UC Davis School of Medicine who blogs about stem cell research at IPCell.com. Also I cant help but wonder, what would be the reaction if someone like Daley spent a few minutes of his talk discussing his embryonic cell research in a very nonconfrontational way? Would he be tasered or drop through some trap door straight to Hell?

Still, Knoepfler was hopeful. I view the canceled Vatican stem-cell meeting as a missed opportunity for a very much needed, open dialogue about stem cells, he told The Daily Beast. More specifically, I believe the reasons for the cancellation reflect an anti-scientific attitude by the highest level of Vatican leaders. More simply put, the attitude might be summed up by the phrase If you do not think like us, you are not welcome at our meeting, and well go so far as to cancel the whole thing to avoid your presence.

Inviting embryonic stem-cell researchers to a conference and then denying them the right to talk about their field of expertise was a major gamble.

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