03-24-2012, 13h30

CHICAGO (AFP)

Patients with advanced heart disease who received an experimental stem cell therapy showed slight improvements in blood pumping but no change in most of their symptoms, US researchers said Saturday.

Study authors described the trial as the largest to date to examine stem cell therapy as a route to repairing the heart in patients with chronic ischemic heart disease and left ventricular dysfunction.

Previous studies have established that the approach is safe in human patients, but none had examined how well it worked on a variety of heart ailments.

The clinical trial involved 92 patients, with an average age of 63, who were picked at random to get either a placebo or a series of injections of their own stem cells, taken from their bone marrow, into damaged areas of their hearts.

The patients -- 82 of whom were men -- all had chronic heart disease, along with either heart failure or angina or both, and their left ventricles were pumping at less than 45 percent of capacity.

None of the participants in the study were eligible for revascularization surgery, such as coronary bypass to restore blood flow, because their heart disease was so advanced.

Those who received the stem cell therapy saw a small but significant boost in the heart's ability to pump blood, measuring the increase from the heart's main pumping chamber at 2.7 percent more than placebo patients.

The treatment worked best in the youngest patients, those under 62, according to the analysis which was done after six months of treatment.

More here:
Stem cell treatment could repair heart damage

The departure of three University of Nebraska regents this year and the re-election campaign of a fourth is reviving debate over a controversial issue some believe should be laid to rest.

Two of the three departing regents, Chuck Hassebrook of Lyons and Jim McClurg of Lincoln, opposed a proposal considered by the Board of Regents in November 2009 that would have limited embryonic stem cell research at the University of Nebraska Medical Center to only cell lines approved under former President George W. Bush. Expansion had become a possibility since President Barack Obama relaxed the Bush guidelines.

Hassebrook and McClurg joined two other regents in killing the proposal by voting against the four who supported it. Pro-life activists believe embryonic stem cell research is morally wrong because harvesting the stem cells requires destroying an embryo.

Regent Randy Ferlic of Omaha, who supported the proposal to limit the research, also will leave the Board of Regents after this year. Bob Whitehouse of Papillion, who opposed the measure, is seeking re-election. Ten candidates are seeking the three retiring regents' seats, and candidate, Larry Bradley, is challenging Whitehouse.

Pro-life advocates said they see opportunity in the departure of two of the regents who opposed limiting stem cell research, but they aren't ready to say they'll ask like-minded regents to reintroduce a proposal to limit the research.

"That would be a place we could stand to gain if we had pro-lifers in the race who we're willing to endorse," said Julie Schmit-Albin, executive director of Nebraska Right to Life.

Nebraska Right to Life endorsed McClurg during his regents campaign, and Schmit-Albin said she believed he would have supported limiting embryonic stem cell research. When he voted against the proposal, however, Nebraska Right to Life ended its support of him, she said.

The group has become more careful in choosing candidates to endorse, Schmit-Albin said, sending out surveys to candidates and incumbents seeking re-election before the primary. It has yet to receive responses from those surveys, she said, so Nebraska Right to Life has yet to endorse any candidates this year.

Schmit-Albin said some regents candidates have contacted the group seeking endorsement, but she declined to name them. She said the group wouldn't endorse Whitehouse because he voted against the stem cell proposal in November 2009.

"He already has a record," she said.

Read more from the original source:
Stem cell controversy could see new life with regent election shuffle

SATURDAY, March 24 (HealthDay News) -- An innovative approach using patients' own bone marrow cells to treat chronic heart failure came up short in terms of effectiveness, researchers report.

Use of stem cell therapy to repair the slow, steady damage done to heart muscle and improve heart function is safe, but has not been shown to improve most measures of heart function, the study authors said.

"For the measures we paid most attention to, we saw no effect, there is no question about that," said researcher Dr. Lemuel Moye, a professor of biostatistics at the University of Texas School of Public Health in Houston.

"Ultimately, this is going to pay off handsomely for individuals and for public health in general, but it's going to take years of work," Moye said. "We are the vanguard looking for new promising lines of research."

While the hoped-for results didn't materialize, there appeared to be a small improvement in some patients, he said. "When we looked at another commonly used measure of heart function called ejection fraction, or the strength of the heart's pumping, that's where all the action was," Moye noted.

It's hard to know which measures of heart function to look at, Moye explained. "We have had some difficulty with that," he said.

Future research will look at other measures of heart function, pay more attention to the characteristics of the cells that are injected and determine which cells are best, he added.

Cardiac cells and other types of specially prepared cells are available now that were not accessible when this study started in 2009, Moye pointed out.

The results of the trial, which was sponsored by the U.S. National Heart, Lung, and Blood Institute, were to be presented Saturday at the American College of Cardiology's annual meeting in Chicago. The report was also published online March 24 in the Journal of the American Medical Association.

For the study, Moye and colleagues worked with 92 patients, average age 63 and mostly male, who had heart failure with and without chest pain. They were randomly assigned to receive either an injection of 100 million bone marrow cells from their own bone marrow, or an inactive placebo. Patients in both groups also received aggressive medical therapy.

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Stem-Cell Trial Failed to Treat Heart Failure