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On the way to quantum sensors – EurekAlert

Posted: August 14, 2022 at 2:32 am

image:Schematic of a quantum sensor in which a biomolecule (pink) is anchored to a surface of hexagonal boron nitride on which the spin defect (red) is located. The latter operates as a sensitive probe for the environment. view more

Credit: Andreas Gottscholl / University of Wuerzburg

The new research project IQ-Sense - Integrated Spin Systems for Quantum Sensors aims to measure physical quantities such as temperature, pressure, magnetic or electric fields with unprecedented precision. Such measurements using quantum sensors are of fundamental importance in the natural and engineering sciences, but also in the life sciences and medicine.

The project brings together research groups from Julius-Maximilians-Universitt Wrzburg (JMU) and Technische Universitt Mnchen (TUM), both in Bavaria, Germany. The complementary expertise represented in the project includes physics, chemistry, life sciences and medicine.

On the one hand, the synergistically linked groups from the two universities aim to explore the fundamentals of advanced quantum sensor technology using several identified solid-state platforms. On the other hand, they are going to develop and demonstrate integrated quantum sensors for spectroscopic and imaging applications in biomolecular and biomedical settings.

The project is coordinated by the Wrzburg Professor Vladimir Dyakonov, head of the JMU Chair of Experimental Physics 6. Other JMU participants come from the Institute of Physics, the Biocentre and the Rudolf Virchow Centre for Integrative and Translational Imaging.

Free State promotes lighthouse projects

The Bavarian State Ministry of Science and the Arts is funding IQ-Sense as part of the initiative "Lighthouse Projects for Research, Development and Applications in Quantum Sciences and Quantum Technologies". Around three million euros have been approved for the project over three years. Half of the sum will go to Wrzburg.

Minister of Science Markus Blume: "We want to specifically support interdisciplinary and cross-university projects that can lay the foundations for groundbreaking innovations. Innovations that we can't even imagine exist today."

New quantum professorship for Wrzburg

As part of this Bavarian funding initiative, JMU will also receive a new quantum professorship for Computational Quantum Materials. The Ministry already announced this in June 2022; the appointment procedure for the professorship is underway. The new professorship was applied for by JMU physics professors Bjrn Trauzettel and Ralph Claessen.

The Free State is funding the establishment of the new professorship at JMU with around 1.5 million euros over five years.

Both successful applications will strengthen the Wrzburg-Dresden Cluster of Excellence "ct.qmat - Complexity and Topology in Quantum Matter".

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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New Five Points Venue Will Showcase Denver Music, Art, Food and Wellness – Westword

Posted: August 14, 2022 at 2:32 am

Three longtime local creatives are coming together to make some magic in the Mile High City. And if Iman Haidar, Crystal Wiggins and Corey Jacobs hit their mark, Society Denvercould be one of Denver's best venues when it opens early next year at 3090 Downing Street, a big building on the edge of Five Points that got its start as a church. The lineup of offerings they propose for the place is enticing and seemingly endless, including live music from local, national and international acts; yoga and meditation classes; body work; workshops; galleries for artists; healthy, soulful food; and even an apothecary and elixir bar.

Our goal with Society is to set a precedent of what is possible in a community space in Denver, says Haidar. We are driven to offer more than just a physical space, but to fill it with purpose and inspiration for our community to flourish in. Keeping the synergy of the mind, body and soul as a guiding principle, we are committed to creating an inclusive space that fosters creativity, celebration and connection."

Denver Society has been a long time coming, though.

"The concept came around for me personally around May of 2019," Haidar recalls. "I realized having the intersection of art and music and wellness and healthy food and community is what really has helped me thrive, and I thought it'd be really cool to have a space that has all of it under one roof."

A rendering of the Alive space.

Society Denver

But not without its challenges. The trio found the building almost three years ago; it had been vacant since the Wrangler moved out in 2018.Before it became a bear bar, it was a members-only swingers' club, and before that, a slew of restaurants, from the Kiva all the way back to the Hacienda, which the MacIntosh family opened after converting the former church into an eatery.

"The building is now owned by GHC Housing Partners, which is normally involved with developing affordable housing. Weve been working directly with Alex Berbit, and a commercial space like this took some creativity and patience," says Haidar. "They didnt want to just sign a lease with any business they could; they wanted a business that aligned with their values. Overall, they have showed up with such support for our success and truly believe in our concept and the value that we will be giving back to the neighborhood and community. Theyve been amazing to work with, and we feel really grateful to be in their building.

"The pandemic hit right before we signed the lease," she recalls. "So we kind of had some ups and downs with that, but ultimately, that place has always felt like where it's meant to be. It just fits so well. It flows so well. It has sectioned-off areas, but they all feel so symbiotic with each other. And now when I walk in, I can't imagine it being anywhere else."

The founders' ideas are backed up by years of experience. Jacobs opened Thrive in Boulder in 2015, and the popular vegan eatery was named a top ten Colorado restaurant by National Elite in 2018. He also has an audio engineering degree and is a reiki master and massage therapist. Wiggins had a background in music festival production, artist management and as an agent when she moved to Denver twelve years ago; she established herself here working with Beatport, Sonic Bloom, Sub.mission, Cervantes', UMS and Yeah Baby, a disco pop-up in RiNo."I have been a talent buyer at multiple different events and festivals globally and in Colorado," Wiggins says. "I'm really looking forward to implementing the skills that I have."

Haidar also has a music background, having worked at Black Box and large-scale festivals from Tomorrowland to Burning Man. "I came out here around 2014 for school. I double-majored in biochemistry and integrative medicine, so I come from a strong science background. And then after that, I also went to the Colorado School of Clinical Herbalism and completed the medical herbalism program, so I'm definitely gonna be infusing that into a lot of the stuff and [wellness space] Alive and the apothecary," she explains. "I'm also an avid yogi, and I help to co-run a performance company and an event company called Pyroglyphics. We do all kinds of performance art, such as fire dancing, aerial arts, belly dance, burlesque, contortion, all kinds of circus stuff. We perform internationally, and that's still running right now."

A rendering of Thrive.

Society Denver

Each floor will showcase a different aspect of the creative hub. Society Denver's first floor will be a second location of Thrive; the space will be filled with greenery and have enough room to allow for performances at dinner. "We'll have Iman coordinating aerials and different types of shows like belly dancing, and we'll have music theater events and different dinner and theater experiences...for a full sensory experience," Wiggins says.

Performance art will also happen on the next floor, labeled Vibe. This will be Wiggins's arena, a sprawling space with VIP booths and a capacity of 600. "No one wants to be shoulder to shoulder at a concert," Wiggins says. Those concerts will include all genres of music."We want to have local artists, we want to support the community," she adds. "We're so tied in with so many different communities with the music as it is, too, that we already have a ton of people ready to support us that are on an international, massive level."

During the day, the first floor will house pop-up galleries and be used as a general gathering and workspace, as well.

The third floor, Alive, will showcase Haidar's expertise. The wellness space will host many holistic offerings, such as energy and body work, sound baths, masseuses, yoga and more.

The building will also house a major mural project headed by Allie Grimm, aka A.L. Grime, named the Best Influential Muralist in the Best of Denver 2022. The project will involve twenty artists, who will paint both the interior and exterior of the space. Grimm's mural will be outside Alive, and will be created during the mural festival she is coordinating, Denver Walls.

"Allie's a longtime friend of mine," Haidar says. "She's also just an inspiring, badass woman powerhouse in her industry. We've worked together for years, and she's already curated a bunch of the murals that are up at the building."

A rendering of Vibe's daytime look.

Society Denver

But first, the partners need to finish and staff the space. They are hiring for more than sixty positions and have created an IndieGoGo to reach a $50,000 goal, which will be used for purchasing more equipment, furnishing, employee training and renovations. Donors will receive perks ranging from yoga classes to food and membership deals.

"Society Denver is open to everybody. You don't need to be a member to access any aspect of it at any point in the day except for some select private events," Wiggins notes.

"We're very connected in the art world," she continues. "We have a friend who's going to be making us a custom chandelier. He's a glassblower here. There are so many cool little things like that, but we're just so excited to bring attention to these people at Society Denver. They deserve it."

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Adtalem Global Education Medical Schools Partner with Southern California University to Expand Pipeline of Physicians – Business Wire

Posted: August 14, 2022 at 2:32 am

CHICAGO--(BUSINESS WIRE)--Adtalem Global Education (NYSE: ATGE), a leading educator and provider of professional talent to the healthcare industry, has established a partnership between its two medical schools, American University of the Caribbean School of Medicine (AUC) and Ross University School of Medicine (RUSM), and Southern California University of Health Services (SCU) to expand access to education for aspiring physicians looking to earn a Doctor of Medicine (MD) degree. Through this partnership, SCU students who graduate from the Master of Science in Medical Science (MSMS) program and get accepted to either AUC or RUSM, can receive up to $10,000 in scholarships or additional funding. The three-year agreement began in July 2022.

Adtalem and its leading medical institutions, AUC and RUSM, are committed to expanding access to education and supporting students to pursue medical education, said John Danaher, M.D., president of Adtalem Medical and Veterinary. This partnership will provide needed funding to a diverse group of students who have the talent but may not have access or opportunity to pursue their education and career path in the health sciences.

SCUs post-baccalaureate MSMS degree can be completed in as little as one year and seeks to strengthen students academic skills and credentials for entry into medical, dental, physician assistant, veterinarian, or other professional health care programs.

"This new agreement is excellent news for SCU MSMS students with dreams of becoming medical doctors, said Raheleh Khorsan, Ph.D., program director, MSMS Program at SCU. SCU is proud to have been educating medical science students since our MSMS Program began in 2020. This agreement creates the opportunity to increase the number of both medical sciences students, and future medical students at AUC and RUSM. It is through institutional agreements such as this that our common goal can be reachedto increase health sciences and medical students to fill the need for additional healthcare professionals for communities."

AUC and RUSM are part of the Adtalem family of institutions dedicated to healthcare workforce solutions and actively partner with mission-driven organizations to reduce educational barriers and empower career development. AUC and RUSM are committed to superior student outcomes and achieved strong residency placements with a combined 95% first-time eligible residency attainment rate for 2021-22 graduates and expected graduates (as of April 5, 2022).

To learn more about the agreement, please visit: https://www.scuhs.edu/wp-content/uploads/RUSM-and-AUC-Interview-and-Scholarship-Details.pdf.

About Adtalem Global

Adtalem Global Education (NYSE: ATGE) is a leading healthcare educator and provider of professional talent to the healthcare industry. With a dedicated focus on driving strong outcomes that increase workforce preparedness, Adtalem empowers a diverse learner population to achieve their goals and make inspiring contributions to their communities. Adtalem is the parent organization of American University of the Caribbean School of Medicine, Chamberlain University, Ross University School of Medicine, Ross University School of Veterinary Medicine and Walden University. Adtalem and its institutions have more than 10,000 employees and a network of more than 275,000 alumni. Adtalem was named one of Americas Most Responsible Companies 2021 by Newsweek, and one of Americas Best Employers for Diversity in 2021 and 2022 by Forbes. Follow Adtalem on Twitter @adtalemglobal, LinkedIn or visit Adtalem.com for more information.

About American University of the Caribbean School of Medicine

American University of the Caribbean School of Medicine (AUC) is an institution of Adtalem Global Education, a global education provider headquartered in the United States. Founded in 1978, AUC School of Medicine has more than 7,000 alumni, many of whom work in primary care or underserved areas. With a campus in Sint Maarten, affiliated teaching hospitals in the United States and the United Kingdom, and internationally recognized faculty, AUC School of Medicine has a diverse medical education program for todays globally minded physician. For more information visit aucmed.edu, follow AUC School of Medicine on Twitter (@aucmed), Instagram (@aucmed_edu) and Facebook (@aucmed).

About Ross University School of Medicine

Ross University School of Medicine (RUSM) is an institution of Adtalem Global Education, a global education provider headquartered in the United States. Founded in 1978 and located in Barbados, RUSM has more than 14,000 alumni and is committed to educating a diverse group of skilled physicians. RUSM is accredited by the Caribbean Accreditation Authority for Education in Medicine and Other Health Professions (CAAM-HP). For more information, please visit medical.rossu.edu and follow RUSM on Twitter (@RossMedSchool), Instagram (@rossmedschool) and Facebook (@RossMedSchool).

About Southern California University of Health Sciences (SCU)

Over a century after Los Angeles College of Chiropractic (LACC), Californias first chiropractic school was established in 1911, it grew into Southern California University of Health Sciences (SCU), an expanded, multi-program university that is transforming and redefining health and healthcare education. SCU is committed to providing an academic community imbued with kindness, integrity, humor, and determination; and a culture of diversity and inclusion. SCU specializes in integrative whole-person healthcare education that goes beyond the diagnosis - and that treats the whole person. Since 1911, SCU has trained more than 18,000 future healthcare providers. For more information, visit scuhs.edu/.

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Advanced Methods in Alternative Cancer Treatment – The Epoch Times

Posted: August 14, 2022 at 2:32 am

Suppose youve received the dreaded diagnosis and youre evaluating your options for treatment. While friends and family may be urging you to go the conventional route, you believe there must be a better, less toxic way than destroy to heal. Heres a glimpse into that other, often hidden world.

Dr. Nathan Goodyear started out as a gynecologist and pelvic floor surgeon. Once out of residency, however, he noticed that a lot of what he had been taught in medical school didnt work. Then, in 2006, he developed pheochromocytoma, a rare type of tumor that develops in the adrenal gland, causing it to excrete high amounts of norepinephrine, which, in turn, causes extremely high blood pressure and heart rate.

That experience pushed him to make the transition into the field of cancer research. For the past 5 1/2 years, hes been working with Brio-Medical, a holistic cancer clinic in Scottsdale, Arizona, and for the past six months, he has served as its medical director. He works with four other physicianstwo medical doctors and two naturopathic physicians.

Goodyear is a firm believer in the benefits of vitamin C in cancer treatment. Coincidentally, were both scheduled speakers at the Vitamin C International Consortium Institutes annual conference in Tampa, Florida, on Sept. 9 and 10.

He says the current approach to cancer has some significant limitations. Places like Brio-Medical are working to find better approaches.

The conventional approach seems to follow the logic destroy to heal, and I just dont know where that really occurs in nature outside conventional cancer treatment. Healing has to be your focus and goal to achieve healing. You have to heal to heal. Our healing strategy focus in cancer is to tap into the bodys designed capacity to heal itself through the targeting of the root causes, Goodyear said.

When you look at holistic natural therapies, theres this assumption by many, including conventional medicine, that we are just throwing darts up on the wall and hope they stick.

But in actuality, were following the science of genomics, epigenomics, transcriptomics, metabolomics, and immunomodulomics. This is the future of medicine thats here now, and were being incredibly specific and targeted for the dysfunction within the cancer, but with natural holistic or integrated therapy.

Examples of holistic therapies used for cancer include vitamin C in combination with artemisinin or artesunate (a primary malaria medication). This combo is very good for prostate and breast cancer in particular. Curcumin and melatonin both also have significant anticancer effects. Goodyear likes to combine hyperthermia with high-dose vitamin C and curcumin.

Studies have shown that when you give vitamin C with whole-body hyperthermia, you actually achieve a higher plasma ascorbic acid concentration. So thats going to impact the fight against cancer more, he said.

Mistletoe is another excellent cancer treatment.

One key point to be made about holistic oncology is that the earlier you start this kind of treatment, the better. Unfortunately, most patients who seek alternative strategies have already done tremendous damage to their bodies, particularly the immune system, with one, two, or even three rounds of chemo, which really impairs your bodys ability to heal naturally.

If we can get them earlier in the process before they get conventional chemo and/or radiation, the impact is huge, Goodyear said.

Before you destroy the immune system, one can actually heal with the immune system. I cant tell you how many ladies with breast cancer have been able to preserve their breasts with this cancer healing strategy. You can actually heal the body, not destroy it. That is a novel concept because when you destroy the immune system through conventional therapy, youre going to see cancer recur and spread.

Typically, its not the initial cancer that kills you. What kills is when the cancer spreads (metastasizes) to other areas of your body. This kind of cancer is typically treated with whole-body therapies, some of which, such as chemotherapy, can have devastating and fatal effects.

The literature is very clearespecially in the last five to 10 yearsthat 90 percent of morbidity and mortality associated with cancer is when it spreads, Goodyear said. Thankfully, research has provided a good understanding of how this chemotherapy and radiation-induced metastasis process occurs.

Maximum tolerated chemotherapy actually induces the mechanisms to spread the cancer. In breast cancer, maximum tolerated chemotherapy will reduce the primary tumor, yet at the same time, cause it to spread to distant locations in the body.

Other cancer therapies, such as radiation therapy, can also cause cancer. Sometimes even the surgeries to remove cancer and even biopsies to test for it can lead cancer to metastasize.

A lot of people that come to us, theyre so surprised. They ask, Why didnt I know about this? Why didnt I know that surgery can cause metastasis? Why didnt I know chemotherapy and radiation can cause metastasis?

The story of vitamin C demonstrates that the devil is in the details. Roughly 50 years ago, Linus Pauling demonstrated that intravenous (IV) vitamin C (10 grams per day for 10 days) improved cancer survival. Later, researchers at the Mayo Clinic tried to reproduce the results but didnt use IV vitamin C. They instead gave 10 grams orally and found no benefit.

In the academic battle that followed, Mayo won and for the next several decades, the conventional thought was that vitamin C doesnt work. That began to change in about the year 2000, when Dr. Ping Chen, a conventional oncologist, started looking into vitamin C and publishing papers on its pharmacokinetics.

Since then, there has been a combination of pushback against the idea that vitamin C works on the one hand and, on the other, growing research that points to vitamin Cs effects being as powerful as any drug.

Vitamin C does have drug-like effects, and I like to refer to it as a pharmaco-mimetic, but its still a natural biological molecule that cant be patented and hence cant be a drug. Also, to be clear, there are distinct differences between whole food vitamin C and ascorbic acid.

They really have two very different purposes. Whole food vitamin C isnt suitable for the treatment of cancer, but does wonders for general health support, as it interacts favorably with copper and iron in your cells and mitochondria. I only recommend and use high-dose IV vitamin C in cases of acute infection or illness, as it does have very potent drug-like effects.

Its actually inducing metabolic changes and epigenetics, Goodyear said. Thats the great thing about natural therapies. Conventional medicine will take an approach to kind of throw a monkey wrench into the bodys physiology to shut everything down without a holistic perspective of how that affects the whole body. Its a very compartmentalized approach.

A holistic approach is like a pebble thrown into a calm pool in the morning. Its effects ripple throughout the physiology of the body. That is the beauty of natural therapies.

Now in cancer and sepsis when were dealing with the major dysfunction found in cancer, where things have metabolically, genetically, immunologically gone off the rails, we have to come in and really work to turn the tide. Thats where the intravenous vitamin C delivery is required. Thats where the sodium ascorbate comes in because thats the only way were going to be able to change that tide.

When treating cancer, IV needs to be used because you simply cant take the high dosages required orally. Doses of more than 10 to 20 grams of ascorbic acid will cause loose stools when taken orally, but IV administration bypasses the limitation of the gut. It also allows the vitamin C to get directly into the blood to the extracellular fluid, into the tumor microenvironment, to penetrate the tumor and saturate the entirety of the tumor.

If you feel like youre coming down with an infection, such as a flu or cold, oral vitamin C is plenty adequate. Oral dosing of vitamin C, using a non-liposomal product, can double your blood level of vitamin C. Using liposomal vitamin Cwhich is what Ive been recommending for yearscan increase it threefold to fivefoldup to about 300 micromolar. So, liposomal vitamin C can make a big difference.

However, when youre dealing with cancer, you need a minimum of 1,000 micromolar, or 1 millimolar, in the extracellular fluid to kill cancer cells, which is why you really need to use IV. In the case of large tumors or significant cancer spread, much higher plasma concentrations are required.

While the dosage is highly individual to each patient, as a general benchmark, Goodyear typically starts at 1.5 grams per kilogram, which for the average person would be somewhere between 100 and 200 grams per dose, three times a week.

So to be clear, I dont advise taking ascorbic acid for daily vitamin C requirements. I strongly suggest that you use whole food vitamin C, which is far superior as a daily source.

Vitamin C has a wide variety of effects, which can be generally classified into the following: genomic, epigenomic, transcriptomic, proteomic, metabolomic, and immunomodulatomic.

The point here is that vitamin C is not just directly killing cancer cells, what we would call cytotoxic effects. Vitamin C is actually working to change the metabolism of the cancer, Goodyear said.

What that means is, it creates an energy crisis. It actually depletes the body of certain intermediates that make it so this cancer, which is addicted to sugar, cannot use [the sugar] efficiently to make energy, so it dies. It also depletes [the cancer] of its ability to detoxify.

So to be specific, research shows that vitamin C depletes the cancer of reduced glutathione. And getting rid of that glutathione in that cancer eliminates its ability to handle the high oxidative stress that this pro-oxidative vitamin C therapy induces, which kills the cancer cell.

It also disrupts how cancer makes energy. And its fascinating because everybody looks at this and they ask, Well, how will this affect my healthy cells? This is the paradigm changer with vitamin C.

The environmentas much as the dose, as much as the delivery, as much as the tumor saturationthe environment encountered by that vitamin C dictates the result as much as the dose itself. So you can induce a pro-oxidative effect, a detoxification crisis, an energy crisis, in cancer cells, and healthy cells do just fine.

When you think of vitamin C, youre probably thinking its an antioxidant, which is true. But in high doses only available through IV, it actually becomes a pro-oxidant, and thats what allows it to kill cancer cells and gives it its antiviral and antibacterial properties.

And theres plenty benefits of that. Thats why its so helpful in viral and bacterial infections. Its countering that cytotoxic burst found in infection. Its donating an electron and becomes oxidized [which neutralizes oxygen], Goodyear said.

He noted that this is why vitamin C can help people with sepsis, including COVID-19 sepsis, and the cytokine storm that causes most of the fatal lung damage resulting from severe COVID.

Its different effects are dictated by the different environmentsit can become pro-oxidative, Goodyear said.

When vitamin C is pro-oxidative, it has a helpful effect on cancer patients.

Its delivering the oxidative stress to the tumor and creating it through hydroxyl free radicals, hydrogen peroxide, superoxide anions, he said.

Goodyear also uses melatonin for cancer treatment and monitors patients melatonin levels to ensure proper dosage. Typically, patients will start off with IV melatonin at a dose of 10 to 20 milligrams daily for two weeks to get the level up as quickly as possible while simultaneously taking oral melatonin at a dose of about 60 milligrams per day. The oral dose is then adjusted based on body weight and other parameters.

Ideally, your blood level is supposed to peak at around midnight. So with that in mind, if youre going to do the oral dose, you want to take the highest dose right before bed, maybe 45 minutes before, and then right before bed, he said.

The other doses, if youre going to do it three times a day, would be maybe 10 a.m. and 4 p.m. You really want to keep it away from solar noon. Otherwise, youre going to [impair your] chronobiology.

Goodyear said they try to adjust the dosing of melatonin so it harmonizes with the patients sleep cycle, but the first priority is the cancer.

When patients come to us, so many of them are in an advanced stage, so in that acute setting, we have to use these therapies in combination and sequence, together, to really turn the tide against the cancer.

Goodyear said his cancer clinic sees mostly patients with metastatic cancer who have already had treatment.

In those patients, in a six-week or maybe eight-week cycle, we can see a significant reduction in tumor burden, he said.

Our goal is no evidence of disease, but were going to typically seein most of our patients, well over 50 percenta significant reduction in that tumor burden while theyre here with us. The after-care is very important to continue that process. What were talking about here is at least a 50 percent reduction in the tumor that you can see clinically, through labs and through imaging.

Many of our patients will come in where the breast is a whole tumor, [or] their spine lights up like a Christmas tree. So its not like we have a patient coming in and they have a small little nodule, OK? These are patients that have failed chemotherapy twice or more, [have had] surgery, radiation [and the cancer] recurred, not just once, but often two or even more times.

Its a tough spot to be in, but if we can set a goal of no evidence of disease and see a 50 percent reduction in these patients, hey, thats something that we can work with because were not destroying the body; actually were working to heal the body.

As mentioned earlier, most of the patients have destroyed much of their bodies innate healing ability through repeated toxic treatments, which makes holistic treatment far less effective. Once chemotherapy damages your immune system, it becomes extraordinarily difficult to treat it.

I know how panic-stricken one can get when given a cancer diagnosis, but if youre in the early to mid stages, you have virtually nothing to lose by going holistic first. Your chances of total remission will be far greater than waiting until all other treatments fail, and you may be able to save your breasts and other parts of your body that would otherwise be cut out.

To make his point, Goodyear offers the case history of a woman with bilateral breast cancer who had been told she needed a bilateral mastectomy, bilateral radiation with chemo, and lymph node dissectionsix to 12 months of brutal and toxic treatments that would have left her disfigured.

When I was talking to her before she came, I said, Let me tell you my approach. Since youve not had any treatment, if we take this in a healing perspective and through a holistic integrative approach, you may just save your breasts, and you may negate the need for any of those other harmful therapies.

And in fact, now shes over two years outcancer-free, no breasts removed, no lymph nodes removed. So here is a person who was headed down that road that would be life-changing in a negative way. We hit the pause button.

She took a chance to think; she took a chance to read. And then she said, You know what? I want a different approach. We addressed it with a holistic evidence-based, integrative approach and now she has both breasts and shes living cancer-free.

She even had COVID and did great. When the immune system is not destroyed, things work so much better, and full-dose chemo destroys the immune system.

Goodyear and I cover a lot more ground in this interview than Ive summarized here, so I encourage you to listen to the full interview online. You can also find more information at Brio-Medical.com.

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Advanced Methods in Alternative Cancer Treatment - The Epoch Times

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New drug screening tool to fight the next pandemic – EurekAlert

Posted: August 14, 2022 at 2:32 am

image:The DrugVirus.info 2.0 portal provides an integrative interactive resource for exploration and analysis of broad-spectrum antiviral drugs (BSAs) and BSA-containing drug combinations (BCCs). view more

Credit: Aleksandr Ianevski

Following two years of severe restrictions, everyone is eager to be done with the coronavirus pandemic. Its tempting to think that COVID-19 is history, but the coronavirus and other viruses will regularly resurface.

What will we do the next time we have a major outbreak?

A research team at the Norwegian University of Science and Technology (NTNU) has been working hard to figure out the answer to this very question for the past six months.

During the coronavirus outbreak, a lot of people thought that malaria medicine might work. It took time to show that it wasnt effective, and many patients died. Our solution can immediately determine which medicine will work or not, says Denis Kainov, a professor of medicine at NTNU.

The solution is simply to reuse and redesign active ingredients that are currently used against various illnesses like cancer or HIV.

Researchers have looked at more than 11000 active ingredients to find the medicinal mix that has the greatest potential to work. The researchers have incorporated information about the active ingredients into a digital system and created an algorithm that can pick out the best ones.

The digital system is openly available online. The solution can save millions of euros, more lives and help us avoid societal shutdowns.

But first a little background on what we are actually facing.

We dont have medicines for 200 viral diseases that can spread in humans, says Kainov.

In other words, we have no medication that can prevent the viruses from multiplying when they start to spread. Developing vaccines for a virus that has not yet spread in humans isnt possible since viruses are constantly mutating.

As with COVID-19, future outbreaks will have plenty of time to spread before a vaccine is readily available.

This is where the NTNU researchers come in with their reuse approach and a brand-new algorithm for developing antiviral drugs.

These are medications that attack the virus itself, and can knock it back right from the start.

Antiviral drugs simply prevent the virus from multiplying. The problem is that developing a new antiviral drug takes about 13 to 15 years and a staggering 20 million euros. Few such options therefore exist. Antiviral drugs currently make up only 4.4 per cent of 4051 approved drugs.

The researchers at NTNU have now investigated all the existing possible active ingredients against viruses. These are molecules that have gone through some of the phases on the way to eventually having medicinal value.

The researchers have created a digital system called Drugvirus.info.

The system will give pharmaceutical companies and other researchers a head start in developing new treatments. Instead of spending research funding over many years, they will be able to cut back their spending to one year. Instead of spending millions on a new treatment, the cost will drop tenfold. NTNUs system will also save companies enormous sums and save more lives.

The system checks what active ingredients already exist that can be reused and redesigned so that we can slow down new outbreaks in the critical phase before a new vaccine is developed, says Kainov.

Reference:Aleksandr Ianevski, Ronja M Simonsen, Vegard Myhre, Tanel Tenson, Valentyn Oksenych, Magnar Bjrs, Denis E Kainov, DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs),Nucleic Acids Research, Volume 50, Issue W1, 5 July 2022, Pages W272W275,https://doi.org/10.1093/nar/gkac348

Nucleic Acids Research

Literature review

DrugVirus.info 2.0: an integrative data portal for broad-spectrum antivirals (BSA) and BSA-containing drug combinations (BCCs)

24-May-2022

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Professor (with Head of Department potential), Department of Medical & Molecular Genetics job with KINGS COLLEGE LONDON | 304203 – Times Higher…

Posted: August 14, 2022 at 2:31 am

The Faculty of Life Sciences & Medicine (FoLSM) is one of Europes largest and most prestigious centres for biomedical education and research. A powerhouse of discovery and innovation, our collective ambition is to deliver tangible improvements to patient care, population health and societal wellbeing. Our vibrant community is comprised of six Schools and a Centre for Education, over 1,200 academic and research staff, and over 6,000 talented students. The Faculty has developed strong links in both education and research with the other health related faculties and more broadly across the College to enable truly interdisciplinary and innovative approaches.

The School of Basic & Medical Biosciences within FoLSM now seeks to hire a Professor within the Department of Medical & Molecular Genetics. The department is home to 17 academic groups with a wide range of research interests and expertise across lab based and computational genetics and from basic discovery to clinical translation. There is an expectation that the successful candidate will carry out cutting edge research in their field, preferably human clinical genetics, so that we may better address the challenges of disease among all populations. The appointee will be an academic leader with significant experience in attracting research funding as PI and in publishing high quality outputs. Experience of fostering strong links with NHS providers would be advantageous.

Research and education at Kings benefits from multiple national and global partnerships and the Academic Health Sciences Centre (AHSC) of Kings Health Partners brings together world-class research, education and clinical practice for the benefit of patients. The Department shares the AHSCs commitment to ensuring faster translation and adoption of research innovation into clinical practice. The successful candidate will therefore bring the required skills to foster interdisciplinary partnerships that increase the reach of the Departments research and education and deliver impacts to benefit society.

The opportunity extends to applying for the role of Head of Department (3 years once renewable term) should this be of interest. The Head of Department will play a leading role in developing the Department through personal mentorship and leadership. The appointee will foster a stimulating, innovative and inclusive environment, enabling students and staff to thrive and develop. Regardless of position(s) applying for, please note that all applicants must have a PhD.

For further information about the role please visit https://jobs.kcl.ac.uk/professor-medical-molecular-geneticsand to apply for this role, please go to the Kings Career pages to submit the specified documentation. Informal enquiries may be made to the Kings Search Team; please contact Sarah Fraser or Matthew Granger at kings-search@kcl.ac.uk

The deadline for applications is11.59pmonWednesday 21st September2022.Interviews will be held inNovember 2022.

FoLSM is proud to hold an Athena SWAN Silver Award, and we expect our community to be committed to embedding an inclusive environment that celebrates and enables the diversity of our students and staff in everything that we do.

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Kathy C. Cordes, a former Baltimore Sun artist who later worked at NASA’s Space Telescope Institute, dies Baltimore Sun – Baltimore Sun

Posted: August 14, 2022 at 2:31 am

Kathy C. Cordes, a former Baltimore Sun artist who later worked at NASAs Space Telescope Institute on the Homewood campus of the Johns Hopkins University, died of congestive heart failure July 29 at Gilchrist Center in Towson. The former longtime Ednor Gardens resident was 71.

Kath was very smart and could easily have been a doctor or a scientist, said Ann Feild, a former Sun artist and Space Telescope Institute colleague and a longtime friend.

She had a strong work ethic, keen research, editorial and problem-solving skills. She was a unique artistic talent who had the ability to do realistic renderings and computer graphics as well as whimsical illustrations, she said. Her talents straddled the arena of art and ever-evolving digital technology.

And what a mind she had. It was wide, deep and expansive. She was also funny as heck and had a fabulous sense of the absurd. And [she was] nobodys fool.

Bonnie J. Eisenhamer, former education program manager in the Office of Public Outreach at NASAs Space Telescope Science Institute, worked closely with Ms. Cordes.

Kathy was one of a kind. She was delightful, pleasant, conscientious and dedicated, Ms. Eisenhamer said. She always went the extra mile to make sure things were right and adhered to national education standards. She always wanted to balance the creative while at the same time meeting our obligations. Ive worked with many artists and not all can do that.

Kathy Cheryl Cordes, daughter of Kenneth L. Cordes, a DuPont Co. chemical engineer, and Margaret A. Cordes, a special education teacher, was born in Wilmington, Delaware, and raised in its North Graylyn Crest neighborhood.

Kathy Cordes was a lab tech before working as an illustrator.

As a youngster, she attended dance, aerobatics and ballet classes, and was curious, as always, even then, said a sister, Holly Cordes Haegele of Pike Creek, Delaware.

After graduating from Brandywine High School, where she had been an exemplary student and a member of the drama club, Ms. Cordes first attended East Carolina University before matriculating to the University of Delaware, where she earned a bachelors degree in plant science. She also obtained a masters degree in psychology from Columbia University.

Early on, however, she spent a few years meandering. Drawn to science, and loving gardening, she got a degree in plant science, according to a 2019 Broadmead Retirement Community profile in Hunt Valley, where she had moved that year. But Kathy always drew and while working as a lab tech at a molecular genetics lab, she submitted some drawings to an anonymous ad in a Washington newspaper, that led to a series of jobs in news graphics.

Ms. Cordes worked for a subcontractor for the National Institutes of Health laboratory in Frederick doing DNA sequencing.

Kath had natural art skills and obviously could make more money doing that than working in the lab, Ms. Feild said. She could do the most realistic portraits and beautiful nature drawings, and could also do 1950s-inspired retro illustrations.

Ms. Cordes launched her career as a news artist when she went to work for United Press International in Washington, and later took a similar position with the The Mercury News, a newspaper in San Jose, California.

She returned to the East Coast and worked briefly for The Washington Times before joining The Sun as a staff artist and illustrator in the mid-1980s.

Twelve years later, Ms. Cordes joined the Office of Public Outreach at the Space Telescope Institute, home of the Hubble and James Webb space telescopes.

There Ms. Cordes worked closely with scientists and educators to convey complex astrophysics data to the lay public with graphics for the web and print publications, Ms. Feild said.

One of Ms. Cordes jobs was designing online teaching tools for Amazing Space a website for teachers and children. She considered it a dream job because it blended science, art and education, according to the Broadmead profile, and another favorite project was working on The Star Witness, a kids astronomy newspaper.

Vernon L. Simms was the chief of staff for the late U.S. Rep. Elijah E. Cummings and also owned and operated a home improvement business.

Kathy was a special woman for sure, Ms. Eisenhamer wrote in an email. She could take a badly drawn idea I had and bring it to life. She always connected to what we needed even when we didnt know ourselves. She made work easier and a more enjoyable place to be.

Kathy had a passion for science and education and she believed in what she did. She was simply the best of the best.

Stratis Kakadelis, former deputy head of the Office of Public Outreach, was another close colleague.

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Kathy had exacting standards of her own no matter how low yours were. You couldnt have anyone better to work with, Mr. Kakadelis said. She did so much to bring the excitement of Hubble discoveries to students and educators. She really had a worldwide impact.

Mr. Kakadelis said they also shared concern caring for older parents.

[Jeffrey Martin Arnstein, an antiques restorer, dies]

Id get to work early and Kathy was always there, he said. She had a sofa chair in her office and Id plop down and we talked, not about work, but of the difficulties of caring for elderly parents. The humanity in her was amazing.

A tall and angular woman with thick gray hair and a face that was highlighted by rimless glasses and brightened by a seemingly endless welcoming smile, Ms. Cordes was an avid gardener who had turned her Rexmere Road home in Ednor Gardens into a floral showplace.

Other pastimes included gesture drawing, paper arts, shadow puppets, origami boxes and reading, writing and watching the sky, according to the profile. She was also an animal lover and participated in animal rescue. She rescued her beloved dog Ernie from the Baltimore Beltway and countless cats who called her Rexmere Road rowhouse their home.

Plans for a celebration-of-life gathering this fall are incomplete.

In addition to her sister, Ms. Cordes is survived by another sister, Judith Kay McClintock of Arden, Delaware.

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Discovery of the interactions between plants and arbuscular mycorrhizal fungi – EurekAlert

Posted: August 14, 2022 at 2:30 am

The arbuscular mycorrhizal symbiosis (AMS) is one of the most ancient and broadly occurring mutualistic associations between plants and arbuscular mycorrhizal fungi (AMF). This intimate relationship improves plant mineral nutrient acquisition, which potentially enhances crop yield. In addition, AMS can increase plant tolerance to biotic and abiotic stresses. AMS also contributes to many ecosystem functions, improving soil aggregation, lowering fertilizer requirements, and reducing nutrient losses. Over the past two decades, several genes involved in AMS have been identified based on changes in symbiosis phenotypes in gene knockout or knockdown mutants.However, the relationship betweenplant SSPs and AMS remains largely unknown.

Recently, scientists from the University of Tennessee established a computational pipeline for genome-wide prediction of SSPs in plants and identified a number of plant SSP candidates that are potentially involved in AMS. Their comparative analysis revealed convergent changes in SSP gene expression and gene regulatory elements between monocot and eudicot species, as well as diversification of protein structure between AMF-inducible SSPs and their closely related homologs, suggesting that SSPs may have played an important role in the evolution of AMS in plants.

Our results indicate that convergence in SSP sequences and gene expression induced by fungi is related to convergent emergence of AMS in diverse plant species, and this is also the first plant kingdom-wide analysis on SSP, Dr. Yangsaid. In summary, the SSP candidates identified in this study lay the foundation for the experimental characterization of AMS-related genes to gain a deeper understanding of the molecular mechanisms that underlie the interactions between plants and AMF.

###

Reference

Authors

Xiao-Li Hu1,2, Jin Zhang3, Rakesh Kaundal4, Raghav Kataria4, Jesse L. Labb2, Julie C. Mitchell2, Timothy J. Tschaplinski2,5, Gerald A. Tuskan2,5, Zong-Ming (Max) Cheng1,6,*and Xiaohan Yang1,2,5,*

Affiliations

1Department of Plant Sciences, University of Tennessee, Knoxville, TN 37996, USA

2Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA

3State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, Zhejiang 311300, China

4Department of Plants, Soils and Climate, Utah State University, Logan, UT 84322, USA

5The Center for Bioenergy Innovation, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA

6College of Horticulture, Nanjing Agricultural University, Nanjing, Jiangsu 210095 China

AboutDr. Xiaohan YangandDr. Zong-Ming (Max) Cheng

Dr. Xiaohan Yang is a Senior Scientist in the Synthetic Biology Group in the Biosciences Division at Oak Ridge National Laboratory (ORNL). He obtained his Ph.D. degree (Horticulture/Plant Molecular Biology/Plant Breeding) from Cornell University, Ithaca, NY. He is editor-in-chief of BioDesign Research (https://spj.sciencemag.org/journals/bdr/). His research covers plant genome editing, plant metabolic pathway engineering, plant-based biosensors, synthetic biology tool development, secure biosystems design, and plant genomics, with a focus on bioenergy crops and plant-microbe interactions to solve renewable energy and environmental challenges. He won an R&D 100 Award in 2018.

Dr. Zong-Ming (Max) Chengis the Editor-in-Chief of Horticulture Researchand also aJoint Professor at Nanjing Agricultural University and University of Tennessee. Dr. Cheng received his BS in Fruit Science from Nanjing Agricultural University in 1982 and his MS (in 1988) and Ph.D. (in 1991) from Cornell University in Ithaca, NY, USA. Over the last 20 years, Dr. Cheng has been working on genetics, breeding, biotechnology, and genomics of fruit, ornamental, and forest trees at North Dakota State University (from November 1990 to July 2001), at University of Tennessee (August 2001 to the present), and jointly at Nanjing Agricultural University (September 2009 to the present). Dr. Cheng has (co)authored about 70 refereed publications, and his research has been funded by the USDA, DOE/CPBR, EPA/CPBR, NSF, and other public and industry sources. Dr. Cheng currently serves as an Associate Editor, Consulting Editor, and Guest Editor-in-Chief for several professional journals. Dr. Cheng was elected a Fellow of the American Society for Horticultural Sciences in 2012.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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A new drug could repair stroke damage to memory and movement – Freethink

Posted: August 14, 2022 at 2:30 am

When a patient suffers an ischemic stroke when a clot chokes off the blood supply of vital oxygen and nutrients to the brain those brain cells begin to die within minutes. The resulting tissue damage can lead to long term complications, including paralysis, memory loss, depression, difficulty controlling emotions, and changes in behavior.

There are currently no FDA-approved therapies for repairing the damage caused by a stroke.

Now, researchers at the University of Cincinnati and Case Western Reserve University have identified a new drug which may help repair not just limit stroke damage.

When a patient suffers an ischemic stroke brain cells begin to die within minutes.

The candidate, called NVG-291-R, led to neurorepair and improved motor skills in mice with surgically-induced ischemic strokes. While time is of the essence in stroke care, the team found that NVG-291-R worked even a week after the stroke.

After the treatment, theyre cognitively improved, their motor skills are improved and this is when we treat them from not just one day, but a full week after injury thats pretty cool, Jerry Silver, Case Western professor of neuroscience and co-author of the Cell Reports study, told New Scientist.

Focusing on neurorepair: Neurorepair is what sets the drug apart.

Most therapies being researched today primarily focus on reducing the early damage from stroke, Agnes (Yu) Luo, senior author and an associate professor in Cincinnatis Department of Molecular Genetics and Biochemistry, said in a statement.

However, our group has focused on neurorepair as an alternative, Luo said although the team also found that NVG-291-R reduced brain cell death to begin with.

The drug repaired the brain via two different mechanisms: by creating new connections between neurons called plasticity and by nudging baby neurons, from neuronal stem cells, to the site of the damage.

Case Western researchers had previously discovered that a molecule that floats in-between cells and is important to neurorepair, called chondroitin sulfate proteoglycans, can cause a stickiness when it gloms onto the receptors that are common in scar tissues. This stickiness hamstrings neurorepair.

The drug repaired stroke damage in mice, improving memory and motor skills.

Our drug prevents this stickiness so the tissue can be repaired, Silver told New Scientist.

Staining techniques showed new nerve fibers sprouting in damaged brain tissue after treatment with the drug.

Neurorepair in mice: To test their drug, the team surgically induced ischemic strokes in 40 mice, and injected them daily with either NVG-291-R or a saline solution beginning a week after their stroke.

The team compared how long it took mice to get out of a maze they had first learned before their stroke to gauge memory improvement, New Scientist explained. Those who had received the drug finished twice as fast, on average, as those who received the placebo.

To test motor function, the team and this is kind of cute, really put tape on one of the mouses paws. Mice who were injected with the drug removed the tape more than twice as fast.

Next steps: More research will be needed to determine if the drugs neurorepair abilities will translate to human stroke victims.

It also has not been tested against other forms of stroke, although Stanley Thomas Carmichael, chair of the neurology department at UCLA, told New Scientist that the same condition the drug targets on is present in other strokes, so it is a possibility. (Carmichael is unaffiliated with the research.)

After the treatment, theyre cognitively improved, their motor skills are improved and this is when we treat them from not just one day, but a full week after injury thats pretty cool.

If the neurorepair drug works in humans, it could represent an entirely new way to treat stroke to not just prevent damage, but actually fix it, even well after a stroke occurs.

The only current FDA-approved drug for treatment of stroke does not repair damage and must be administered within 4.5 hours of stroke onset, Luo said in the statement.

Most therapies being researched need to be applied within 24-48 hours of a strokes onset. A product that works to repair damage from stroke even a week after symptom onset would change the paradigm for stroke treatment.Wed love to hear from you! If you have a comment about this article or if you have a tip for a future Freethink story, please email us at [emailprotected]

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Study Using NanoStrings GeoMx Digital Spatial Profiler Featured on the Cover of Nature Genetics – BioSpace

Posted: August 14, 2022 at 2:30 am

SEATTLE--(BUSINESS WIRE)-- NanoString Technologies, Inc. (NASDAQ: NSTG), a leading provider of life science tools for discovery and translational research, today announced a peer-reviewed paper published in Nature Genetics using the GeoMx Human Whole Transcriptome Atlas (WTA) to construct a high-resolution molecular landscape of pancreatic cancer. This paper, along with a tissue image generated using the GeoMx Digital Spatial Profiler (DSP), is featured on the cover of the August 2022 edition of Nature Genetics.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220809005149/en/

A tissue image generated using NanoString's GeoMx Digital Spatial Profiler (DSP) is on the cover of Nature Genetics. (Graphic: Business Wire)

The paper, Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment, was authored by a team led by William L. Hwang, M.D., Ph.D., Assistant Professor at Harvard Medical School and Clinician-Investigator in the Center for Systems Biology, Center for Cancer Research and Department of Radiation Oncology at Massachusetts General Hospital.

Since pancreatic cancer is one of the most challenging malignancies to treat with standard approaches, the research team sought to advance precision oncology strategies by understanding the molecular landscape of the multicellular subtypes and spatial communities of this cancer, including how they are remodeled after treatment.

The researchers used single-nucleus RNA sequencing (snRNA-seq) and digital spatial profiling with the GeoMx WTA to profile the tumors from a cohort of patients before or after neoadjuvant intervention. The snRNA-seq cell type signatures were used to deconvolve the GeoMx spatial profiles, demonstrating the complementarity of the two platforms. Together, the platforms demonstrated that malignant cells following different cellular programs (basal-like vs. classical-like) cluster in distinct immune niches within a tumor. The spatially-resolved transcriptomics analysis supported the hypothesis that basal-like malignant cell programs and classical-like programs drive different degrees of immune infiltration with distinct immune cell compositions and suggests that therapeutic strategies may be more effective if differentially targeted for these specific phenotypes.

Since resistance to cytotoxic therapy is pervasive, there is a critical need to elucidate clinically-relevant gene expression programs and spatial relationships among malignant and stromal cells in the tumor microenvironment, particularly in residual disease, said Hwang. GeoMx spatial technology was critical in achieving this research objective because it allowed us to map our single-nucleus gene expression programs onto the tumor architecture with high fidelity (whole transcriptome) and in a cell-type specific manner (morphology antibody-based segmentation) and was optimized for FFPE samples, which is the specimen format that is most commonly available in the clinic. This unique combination of technological features enabled us to refine our understanding of the molecular taxonomy and spatial organization of PDAC that will ultimately advance precision oncology for this deadly disease.

The high-resolution molecular framework sheds light on pancreatic cancers inter-and intra-tumoral diversity, spatial organization into discrete communities, treatment-associated remodeling, and clinically relevant prognostication. With these findings, researchers can harness this information to augment precision oncology efforts in pancreatic cancer and drive significant breakthroughs in oncology research.

About NanoString Technologies, Inc.

NanoString Technologies is a leading provider of life science tools for discovery and translational research. The company provides three platforms that allow researchers to map the universe of biology. The nCounter Analysis System, cited in more than 6,000 peer-reviewed publications, offers a way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision. NanoStrings GeoMx Digital Spatial Profiler enables highly multiplexed spatial profiling of RNA and protein targets in various sample types, including FFPE tissue sections, and has been cited in more than 100 peer-reviewed publications. The CosMx Spatial Molecular Imager, with commercial availability expected in 2022, enables highly sensitive, high-resolution imaging of hundreds to thousands of RNAs or proteins directly from single cells within morphologically intact whole tissue sections. For more information, visit http://www.nanostring.com.

Forward-Looking Statements

This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. These forward-looking statements include statements regarding our products and the anticipated launch of new products and technology. Such statements are based on current assumptions that involve risks and uncertainties that could cause actual outcomes and results to differ materially. These risks and uncertainties, many of which are beyond our control, include market acceptance of our products; the extent and duration of the impact of the COVID-19 pandemic and adverse conditions in the general domestic and global economic markets; the effects of ongoing litigation; the impact of competition; the impact of expanded sales, marketing, product development and clinical activities on operating expenses; delays or other unforeseen problems with respect to manufacturing and product development; as well as the other risks set forth in our filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof. NanoString Technologies disclaims any obligation to update these forward-looking statements.

NanoString, NanoString Technologies, the NanoString logo, CosMx, GeoMx, and nCounter are trademarks or registered trademarks of NanoString Technologies, Inc. in various jurisdictions.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220809005149/en/

Contacts

Doug Farrell, NanoStringVice President, Investor Relations & Corporate Communicationsdfarrell@nanostring.com Phone: 206-602-1768

Source: NanoString Technologies, Inc.

A tissue image generated using NanoString's GeoMx Digital Spatial Profiler (DSP) is on the cover of Nature Genetics. (Graphic: Business Wire)

View this news release and multimedia online at:http://www.businesswire.com/news/home/20220809005149/en

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