CHAMPAIGN, Ill. Light-activated proteins can help normalize dysfunction within cells and could be used as a treatment for diseases such as cancer or mitochondrial diseases, new research suggests.

Researchers from the University of Cincinnati, the University of Illinois Urbana-Champaign and the University at Buffalo published the results of their study in the journal Nature Communications.

The research centers on the functions of mitochondria, organelles within a cell that act as the cells power plant and source of energy. Hundreds of mitochondria are constantly coming together a process called fusion and dividing into smaller parts a process known as fission to stay balanced in healthy cells, said study leader Jiajie Diao, a professor of cancer biology at UC. But when mitochondria are not functioning properly, there is an imbalance of this process of fission and fusion.

This imbalance can lead to a number of mitochondrial diseases, including neurodegenerative diseases like dementia and certain cancers.

Previous research found that another organelle within cells called a lysosome can play a role in mitochondria fission. When a mitochondria comes in contact with a lysosome, the lysosome can act like a pair of scissors and cut the mitochondria into smaller pieces.

The current research focused on jump-starting the fission process by bringing the lysosomes and mitochondria together within cells. This was accomplished using a technique known as optogenetics, which can precisely control specific cell functions using light.

Many proteins in plants are light-sensitive, informing plants whether it is day or night. Optogenetics borrows these light-sensitive proteins from plants and uses them in animal cells, said study coauthor Kai Zhang, a biochemistry professor at Illinois who developed the optogenetic tools for controlling mitochondria and lysosomes with blue light. By attaching such proteins to organelles, one can use light to control the interaction between them, such as mitochondria and lysosomes shown in this work.

The researchers attached two separate proteins to mitochondria and lysosomes within stem cells. When stimulated by blue light, the proteins naturally bind to each other to form one new protein, which also brings the mitochondria and lysosome into contact. Once they are brought together, the lysosome can cut the mitochondria, achieving fission.

We found that this technique can recover mitochondrial function, Diao said. Some of the cells even can go back to normal. This proves that just by using some simple light stimulation, we can at least partially recover the mitochondrial function of the cell.

This technique could be especially useful for patients with dramatically oversized mitochondria that need to be divided into smaller pieces to achieve normal cell function, Diao said. The technique also could be aimed at cancer cells, continually separating the mitochondria into smaller pieces until they can no longer function.

Eventually the cancer cell will be killed because mitochondria are their energy, Diao said. Without normal functional mitochondria, all of the cancer cells will be killed.

Since the proteins are activated by light, the optogenetic technique allows for a more targeted approach to specific cells, Diao said. Only cells exposed to the light are affected, meaning healthy cells nearby do not have their mitochondria unbalanced through the technique.

There are currently other processes that can be used to induce mitochondrial fission, but Diao said the optogenetic method is safer since it does not involve chemicals or toxic agents.

What we have is actually the natural process, were just making it faster, Diao said. So its not like a chemical or a therapy or a radiotherapy, where you need to reduce the side effects.

Diaos team is using the same technique to encourage fusion to address issues when mitochondria are unbalanced because they are too small and not coming together as they should within cells.

Further research from Zhangs lab also will include developing new optogenetic systems working with different colors of light, including green, red and infrared, since a longer wavelength will be needed to penetrate human tissue.

We would like to further expand the toolbox by introducing multicolor optogenetic systems to give us multiple ways to control how organelles behave and interact, Zhang said. For instance, one color makes organelles come together, while the other color forces them apart. This way, we can precisely control their interactions.

From the current research using human stem cells, the team hopes to progress to animal models on the way to eventually testing the technique in humans through clinical trials. At the same time, other research groups are studying the use of magnetic fields and acoustic vibrations instead of light to accomplish similar results, Diao said.

The National Institutes of Health supported this work.

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Light-activated technique helps bring cell powerhouses back into balance - University of Illinois Urbana-Champaign

Report Ocean recently added a research report on the Single-cell Analysismarket. The report includes an extensive analysis of the markets characteristics, COVID-19 impact, size and growth, segmentation, regional and country breakdowns, competitive environment, market shares, trends, and strategies. In addition, it traces the development of the market over time and projects regional market growth. It compares the market to other markets and situates it in relation to the larger market.

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Single-cell Analysis Market is predicted to grow at a CAGR of ~17.1%. The market is predicted to reach $2005 million in 2026 from $763.4 million in 2020.

Single-cell Analysis Market by Product, Cell Type, Technique, End User, and by Geography .North America, Europe, Asia Pacific and Rest of the World)- Forecast to 2026Single-cell analysis is the examination & study of proteins, study of small molecules, and other cells at the single-cell level. This analysis allows the study of variations of cell-to-cell in the group of cells. The objective of the single-cell analysis is to gain insight into the mechanisms of cellular functionality, which requires an understanding of each of the cellular components, including protein content, DNA, and RNA, as well as the cellular metabolites.

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The information collected from this analysis is significant for cancer research for the discovery of tumor cells and genetic diagnosis. The factors such as advanced technology in products of single-cell analysis, increasing preference for customized medicine and rapidly increasing various chronic diseases such as cancer, which fuel the demand for the single-cell analysis market. However, the expensive products in the single-cell analysis are restraining market growth. Single-cell Analysis Market is predicted to grow at a CAGR of ~17.1%. The market is predicted to reach $2005 million in 2026 from $763.4 million in 2020.

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The Single-cell Analysis Market is segmented as follows:

Based on Product:ConsumablesBeadsMicroplatesReagentsAssay KitsOther ConsumablesInstrumentsFlow CytometersNGS SystemsPCR InstrumentsSpectrophotometersMicroscopesCell CountersHCS SystemsMicroarraysOther Instruments

Based on Cell Type:Human CellsAnimal CellsMicrobial Cells

Based on Technique:Flow CytometryNext-generation SequencingPolymerase Chain ReactionMicroscopyMass SpectrometryOther Techniques

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Based on End User:Academic & Research LaboratoriesBiotechnology & Pharmaceutical CompaniesHospitals & Diagnostic LaboratoriesCell Banks & IVF Centres

Based on Geography:North AmericaEuropeAsia PacificRest of the World

In the product based segmentation consumables segment is expected to have the largest share in the market. The reasons for the demand for consumables products are regularly purchasing the consumables compared to the instruments and the significant usage of consumables in the research and genetic exploration and segregation of RNA and DNA.

Based on cell type segmentation, the human cell segment is having the largest share in the market. The human cell is greatly used in the research laboratories due to the rising incidence of infectious diseases in the elderly population and the high investments in stem cell research.On the bases of technique, the next-generation sequencing segment is expected to have the largest share in the market due to the increasing chronic diseases and next-generation sequencing allowing researchers to perform various applications.

Further, based on end-user segmentation, the academic and research laboratories segment is expected to have the largest share in the market. The increasing number of colleges and universities of medical and high investments in life science research are the factors accelerating the demand for single-cell analysis.

Moreover, based on the geography Asia Pacific region is playing a vital role in the market share compared to other regions due to rising number of patients in countries such as China and India, growing investments in the research and development in this field and outsourcing of drug discovery services to the Asia Pacific region. In addition, North America is the second-largest contributor to the market due to the high expenditure in the research and development and increased scope for stem cell research in this region.

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The single-cell analysis market is expanding globally due to the increasingly advanced technology in the single-cell analysis products. The major factors accelerating the single-cell analysis market include rapidly increasing chronic diseases and cancer cases all over the world, increasing biotechnology & biopharmaceutical industries, and life science research. Although, due to high competition, the persistence of new entrants and small players is difficult in the market, and this is a challenge for market growth. The emerging markets in Asia are the future opportunities for the market.

The key market competitors in the market are Becton, Dickinson and Company, Danaher Corporatio, Merck Millipore, Qiagen N.V., Thermo Fisher Scientific, Inc, General Electric Company, BARCO, Promega Corporation, Shanghai Goodview Electronics, Fluidigm Corporation, Agilent Technologies, Inc, Nanostring Technologies, Inc., Tecan Group Ltd, Sartorius AG, LUMINEX CORPORATION, Takara Bio Inc., Takara Bio Inc., Fluxion Biosciences and Menarini Silicon Biosystems.

Moreover, the single-cell analysis has the largest scope in cancer research for the detection of the various tumor cells, preimplantation, and genetic diagnosis as the drastic increase in the cancer cases globally. The government is also supporting financially for cell-based research.The single-cell analysis market report provides the present drifts, opportunities, restraining factors, and the challengesThis report provides the overall analysis of the strategies acquired by market players based on the competitive analysisThis report gives the quantitative analysis of the market which allow the users to perceive the market factual of the overall regions

Table of Content

Market OverviewMarket DynamicsAssociated Industry AssessmentMarket Competitive LandscapeAnalysis of Leading CompaniesMarket Analysis and Forecast, By Product TypesMarket Analysis and Forecast, By ApplicationsMarket Analysis and Forecast, By RegionsConclusions and RecommendationsAppendix

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Single cell Analysis Market Is Likely To Witness Exponential Growth By 2030 | Danaher Corporatio, Merck Millipore, Qiagen N.V., Thermo Fisher...

Report Ocean recently added a research report on the 3D Cell Culture market. The report includes an extensive analysis of the markets characteristics, COVID-19 impact, size and growth, segmentation, regional and country breakdowns, competitive environment, market shares, trends, and strategies. In addition, it traces the development of the market over time and projects regional market growth. It compares the market to other markets and situates it in relation to the larger market.

Other business intelligence tools include market definition, regional market opportunity, sales and revenue by region, manufacturing cost analysis, industrial chain, market effect factors analysis, global market size forecast, market data and graphs and statistics, tables, bar and pie charts, and more. Obtain a thorough report (with a full TOC, more than 100 tables, figures, and charts). Extensive Analysis Impact Analysis of the Pre- and Post-COVID-19 Market Outbreak.

The estimated market value of 3D Cell Culture in 2020 is US$ 2,717.6 million and it is predicted that it will grow at a CAGR of 29.1%.

A 3D cell culture is an artificial environment where biological cells grow or connect with their surrounding habitats in three dimensions. It develops types of different cells and tissues formulation which is not feasible under 2D culture systems. It has more properties of tissue mutation and cell cohesion. The early-stage drug discovery and other related research have earned 3D cell structure increasing popularity which can be seen in its growing application.

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3D cell culture is growing at a fast pace in the healthcare environment because of the significant scale of implementations in various areas like cancer research, vitro environment, and regenerative medicine. It has the potential to understand tissue maturation and formation, organogenesis, and cell differentiation has increased its utility. Now animal prototypes in clinical testing and experiments are replaced because of its similarity with cells in vivo. The 3D cell culture market is majorly driven through the increasing usage of 3D cell culture in diagnostic centers, hospitals, pharmaceutical, and biotech companies. Which directly increases the demand for organ transplantation, tissue regeneration, and regenerative medicine.

The research report segregates the market into the following segments:

By ProductScaffold-based 3D Cell CulturesHydrogels/ECM AnalogsSolid ScaffoldsMicropatterned SurfacesScaffold-free 3D Cell CulturesLow Attachment PlatesHanging Drop Plates3D Bioreactors3D Petri DishesMicrofluidics-based 3D Cell CulturesMagnetic & Bioprinted 3D Cell Cultures

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By ApplicationCancer & Stem Cell ResearchDrug Discovery & Toxicology TestingTissue Engineering & Regenerative Medicine

By End UserPharmaceutical & Biotechnology CompaniesResearch InstitutesCosmetics IndustryOther End Users

Some of the prominent companies in the area of 3D Cell Culture are:3D Biotek, LLCAdvanced Biomatrix, IncBectonDickinson and CompanyCorning IncorporatedKuraray Co., LtdLonza Group LtdMerck & Co., IncSynthecon IncorporatedThermo Fisher Scientific IncVWR Corporation.

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The report also contains insight regarding technological innovations and advanced solutions for the 3D Cell Culture. The study also gives an in-depth idea about the major competitors in the market, their journey and the competitive edge via systematic analytical tools including SWOT analysis. As per Report ocean Research, the estimated market value of 3D Cell Culture in 2020 is US$ 2,717.6 million and it is predicted that it will grow at a CAGR of 29.1%.

There are three important factors which are the driving forces behind the growth of 3D Cell Culture market:

The key features which have fueled its increased its growth are:

The rise in the prevalence rate of cancerGrowing Focus on Personalized MedicineHigh Degree of Corporate Inclusion for Research

The physiologic, histologic, and functional properties of the respective tissues have given the homotypic and heterotypic 3D tissue culture models. These properties enhance the different cellular functions such as adhesion, migration, gene expression, and proliferation. The creation of duct-like structures in vitro environments can be formed by two important factors such as normal polarization and differentiation of epithelial cells as well as with the usage of 3D cultures. Moreover, the synergistic effect required for the interactions of cell-cell and cell-extracellular matrix (ECM), which can control the expression of molecules involved in cell differentiation, is also achieved in 3D cell cultures.

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The potential that 3D models have so that it can minimize the accompanying flaws with 2D monolayer cultures is predetermined to fuel the demand for these techniques in the near future. The rising demand from the shift of 2D to 3D technology is pushing the growth of this market. In addition, opportunistic marketing competitors are entering this segment due to its high market potential. Subsequently, this will further propel the market.

These technologies provide advanced tools that can help to explore key aspects of disease and enable demonstration of micro-environmental factors that support in-vivo tumor growth. 3D concept of artificial cell cultivation provides vast benefits in the analysis of phenotypic heterogeneity of cancers and heterotypic intercellular crosstalk for 3D Cell Culture vendors to fulfill both the residential as well as commercial sectors.

Table of Content

Market OverviewMarket DynamicsAssociated Industry AssessmentMarket Competitive LandscapeAnalysis of Leading CompaniesMarket Analysis and Forecast, By Product TypesMarket Analysis and Forecast, By ApplicationsMarket Analysis and Forecast, By RegionsConclusions and RecommendationsAppendix

Access Full Report, here:-https://reportocean.com/industry-verticals/sample-request?report_id=IR426

About Report Ocean:We are the best market research reports provider in the industry. Report Ocean believes in providing quality reports to clients to meet the top line and bottom line goals which will boost your market share in todays competitive environment. Report Ocean is a one-stop solution for individuals, organizations, and industries that are looking for innovative market research reports.

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3D Cell Culture Market Anticipated to Achieve Lucrative Growth by 2030 with 3D Biotek, LLC, Advanced Biomatrix, Inc, Becton, Dickinson and Company,...