Pregnant women are bombarded with advertisements on social media, in childbirth classes, even in their doctors offices urging them to bank the blood in their babys umbilical cord and gain peace of mind.

Private banks claim that the stem cells inside the blood are a powerful tool to have on hand in case a child one day becomes seriously ill. They charge several thousand dollars upfront for storage plus hundreds more every year thereafter.

But an investigation by The New York Times found that leading banks have consistently misled parents about the technologys promise. The few parents who try to withdraw samples often find that they are unusable either because their volume is too low or they have been contaminated with microbes.

Heres what parents should know about cord blood banking.

In the 1990s, transplant doctors saw cord blood as a promising new source of stem cells for patients with sickle cell anemia and leukemia who could not find suitable matches from their families or bone marrow donor registries.

The major cord blood banks Cord Blood Registry, ViaCord and Cryo-Cell told The Times that the cells they store had saved childrens lives and that no one knew what scientists may one day discover.

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What Parents Should Know About Cord Blood Banking - The New York Times

Marty FM, Ljungman P, Chemaly RF, Maertens J, Dadwal SS, Duarte R, et al. Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation. N Engl J Med. 2017;377:243344.

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Cassaniti I, Colombo AA, Bernasconi P, Malagola M, Russo D, Iori AP, et al. Positive HCMV DNAemia in stem cell recipients undergoing letermovir prophylaxis is expression of abortive infection. Am J Transplant. 2021;21:162228.

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Originally posted here:
Assessment of Cytomegalovirus DNA doubling time and virus-specific T-cell responses in the management of CMV infection in allogeneic hematopoietic...

Chulalongkorn Universitys Faculty of Veterinary Science and the Faculty of Engineering have worked together to research and develop a three-dimensional artificial cornea from stem cells that offers a way to treat deep corneal wounds in dogs. The innovation helps to solve the problem of treatment methods that rely on tissue replacement which is hard to find and very expensive. It makes it possible for dogs to be able to see clearly and comfortably once again.

Does your dog have any of these symptoms? The inability to fully open its eyes, squinting or blinking frequently, shedding lots of tears, sometimes the tears are thick, and the mucus appears greenish. The sclera is unusually red and not clear like before. The cornea becomes cloudy and there are blood vessels in it.

If your answer is yes then your pet might be suffering from a corneal ulcer which, if left untreated could eventually cause blindness.

Nowadays, the number of dogs receiving treatment for corneal ulcers has increased tremendously.The small animal hospital at the Faculty of Veterinary Medicine, Chulalongkorn Universityalone is already treating dogs with corneal ulcers daily.

Veterinarian Dr. Chutirat Torssahakul,the Department of Internal Medicine, Faculty of Veterinary Medicine

We find quite a number of lesions like this in dogs. Corneal ulcers occur as a result of many reasons, such as dogs scratching their own eyes because they have allergies causing itching around the eyes followed by scratching until the lesions form. Fights with other dogs, being scratched by a cat, or accidentally bumps into objectsVeterinarian Dr. Chutirat Torssahakul of the Department of Internal Medicine,Faculty of Veterinary Medicine, Chulalongkorn Universityaddressed the problems that became the starting point for the research and innovation development. Three-dimensional artificial cornea from stem cells enables your beloved pet to have perfect vision once again. The current treatment being used is to have grafts made from replacement tissue derived from porcine bladder or canine placentas which are rare and relatively expensive. There is also the possibility of causing post-surgery reaction and inflammation. Therefore, we thought that if we could produce our own innovative artificial cornea using natural materials that are easily found and reduce the chance of causing inflammation this might be a better option. Dr. Chutirat explained.

Three-dimensional artificial cornea from stem cells a brighter alternative

As a result of the effort and intention to solve eye problems for dogs, the Faculty of Veterinary Sciences research team throughthe Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC)has therefore embarked on additional studies on stem cells and is working with the Biomedical Engineering Research Center of the Faculty of Engineering, Chulalongkorn University recognizing its expertise in tissue engineering to help make adhesive materials for growing stem cells.

Image showing a 3D corneal patch made from silk fibroin and gelatin

According to Veterinary Professor Dr. Chutirat Artificial corneal tissue is obtained by cultivating real dog corneal stem cells on a natural material structure made from silk fibroin mixed with gelatin. The material can be cheaply and easily found in Thailand. It is strong and durable, clear and transparent, and adheres well to cells making them three-dimensional which is comparable to real corneal tissue.

This innovation can be used to treat corneal perforations in dogs as well as large corneal wounds where the tissue cannot be stitched or even deep wounds in which a large amount of corneal tissue has been lost. In cases of dogs with mild or moderate levels of corneal ulcer problems, currently, 2 methods for treatment are still in use.

But in cases where the wound in the cornea is so large that tissue must be used to replace the missing part, we usually use a graft which could be the dogs own conjunctiva. The other option is to use replacement tissue such as tissues derived from human or canine placentas. These are costly and difficult to find so we have invented a new way to treat them and that is the three-dimensional artificial cornea made from stem cells.

4 outstanding features of the 3D artificial cornea innovation

At present, the 3D artificial cornea from stem cells innovation is still in the laboratory testing stage to study whether the 3D artificial cornea can actually be used as a cornea replacement, and to determine how it interacts with the animals body. According to Veterinary Professor Dr. Chutirat in many countries research on such innovations is also currently underway at the laboratory level.

The research we have done has produced satisfactory results. It is expected that this innovation will be applied to dogs in the next few years. Moreover, we have plans to apply this knowledge to cats as well from cell collection, locating cells, separating cells, and arranging cells Dr. Chutirat concluded.

Those who are interested can further read the research paper on the subject at https://pubmed.ncbi.nlm.nih.gov/35120168/

Read the rest here:
3D Artificial Cornea from Stem Cells: Chula Researchers Advance Canine Corneal Wound Treatment - Times Higher Education

Millions of pregnant women get the pitch through their OB-GYN: Put a bit of your newborns umbilical cord on ice, as a biological insurance policy. If your child one day faces cancer, diabetes or even autism, the precious stem cells in the cord blood could become a tailor-made cure.

Many families are happy to pay for the assurance of a healthy future. More than 2 million umbilical cord samples sit in a handful of suburban warehouses across the country. Its a lucrative business, with companies charging several thousand dollars upfront plus hundreds more every year thereafter. The industry has grown rapidly, bolstered by investments from medical device companies, hospital partnerships and endorsements from celebrities such as Drew Barrymore and Chrissy Teigen.

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Cord Blood Registry, in Tucson, Ariz., on June 26, 2024. The company stores more than one million samples, double the number it had in 2014. (Rebecca Noble/The New York Times)

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Renee Johnson in Scottsdale, Ariz., on July 7, 2024. Johnson banked her sons cord blood with ViaCord in 2014 and learned years later the cells were infected with E. coli. (Rebecca Noble/The New York Times)

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Anna Lazos at her home in Egg Harbor Township, N.J., on June 27, 2024. After spending thousands of dollars on cord blood storage, Lazos asked to withdraw a sample to enroll her son in an autism clinical trial. The company told her that the cells were contaminated with E. coli. (Hannah Yoon/The New York Times)

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Jenna Edwards with her son at home in Parkland, Fla., on June 24, 2024. When Edwards tried in 2017 to withdraw her sons cord blood cells for a clinical trial to treat his cerebral palsy, she learned that the company had found bacteria in the sample, but still charged her for the next two years. (Eva Marie Uzcategui/The New York Times)

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Read more from the original source:
Cord Blood Banks Sold Families on False Hope - myheraldreview.com

A German man is reportedly the seventh person in history to be cured of HIV, according to researchers who will present the information at the 2024 International AIDS Conference in Munich, Germany.

Multiple tests given to the German man were unable to detect any copies of the virus in his body following a stem cell transplant for acute myeloid leukemia that occurred in 2015, according to a report in NBC News. The man stopped taking antiretroviral medication for his HIV in 2018 and remains in remission, or a state of having no virus present in the body.

The man has chosen to remain anonymous, but did issue a statement about his medical condition. A healthy person has many wishes, he said, a sick person only one.

The longer we see these HIV remissions without any HIV therapy, the more confidence we can get that were probably seeing a case where we really have eradicated all competent HIV, Dr. Christian Gaebler, a physician and scientist at the Charit-Universittsmedizin Berlin, told NBC News.

While any cure news is always welcomed both in the HIV community and to those outside it, the German mans case is emblematic of a trend that is proving hard to replicate for the 39 million people living with HIV worldwide. In each of the seven cases, according to NBC News, the cure came as the result of stem cell treatments for people living with HIV who had developed blood cancer. Such stem cell transplants are toxic and can be fatal, as NBC News, making it unethical as a treatment for the overwhelming majority of people with HIV.

When HIV enters a persons body, it functionally turns a persons immune cells into factories that make more and more copies of the virus. However, existing alongside these copies of the virus that actively attack a persons immune system is the latent HIV reservoir, a group of immune cells that have been overtaken by HIV but are not currently reproducing new copies of the virus. These dormant cells can awaken at any time, and targeting these cells is a major problem for HIV cure researchers. Often, these reservoirs are located in hard-to-reach areas, including the lymph nodes, the gut, and the brain, according to The Body, an HIV/AIDS news and information site.

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A Seventh Person Has Most Likely Been Cured of HIV Following Stem Cell Transplant - Them

NEW YORK, July 20, 2024 (GLOBE NEWSWIRE) -- Cell BioEngines, Inc., a New York, USA-based company researching stem cells in order to develop new cell therapies unlocked $1.75 million additional funds from SOSV and the Partnership Fund through the new therapeutics seed track, available for therapeutics start-ups. In addition, Cell BioEngines raised $0.25 million from Empire State Developments NY Ventures, the states venture capital arm through the Pre-Seed and Seed Matching Fund Program.

This reflects strong growth and investor confidence in our innovative approach to advancing cell therapies, particularly timely as we expand within New York State, said Dr. Ajay Vishwakarma, Founder and CEO.

The funds will support our first multicenter clinical trial, aimed at hematological cancer patients unable to find a donor and seeking an alternative to HLA-haploidentical blood stem cell transplants. CBE-101 represents a novel approach with expanded cord blood-derived hematopoietic cell therapy, aligned with Cell BioEngines' vision to deliver 'off-the-shelf' cell-based therapies to patients, he added.

About Cell BioEngines

Cell BioEngines, Inc., founded in Dec 2022, is a clinical-stage biotech company focused on developing allogeneic 'off-the-shelf' stem cell-derived therapies as drugs for human disease treatment. The company leverages its proprietary platform technology using universal 'non-gene-modified' donor blood stem cells obtained from umbilical cord to produce clinical grade cells at scale.

For more information about Cell BioEngines, and to learn more the latest Company developments, please visit http://www.cellbioengines.com

Contact

Mark Joubert., J.D. Chief Legal Officer Cell BioEngines, Inc info@cellbioengines.com

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Cell BioEngines Secures an Additional $2 Million in Funding - GlobeNewswire