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Trans teens: We need to be heard, counted. In Michigan, the backlash is harsh – Bridge Michigan

Posted: July 19, 2022 at 2:00 am

You cant understand what you dont measure

Numbers are hard to come by, but Prins is one of about 3,950 Michigan youths between ages 13 and 17 who identified as transgender in 2020, according to the Williams Institute of UCLA.

Nationwide, there are more than 60 gender clinics treating transgender and nonbinary adolescents using gender-affirming care, nine of which are in Michigan.

Overall, nonbinary youths are believed to represent less than 1 percent of the more than 640,000 adolescents in Michigan. Nationally, their numbers are believed to be rising fast, as more come out, according to estimates from the Centers for Disease Control and Prevention.

Cataloging their population is tough, though, because the federal government has not allowed school districts to report data on nonbinary students, just males and females.

That may soon change as federal officials consider changing policies to allow but not require schools to collect the data.

The proposal comes from the federal Office of Civil Rights, which is considering collecting data on nonbinary students for its 2021-22 report in December, which identifies chronic absenteeism, sexual assault, school safety, harassment and bullying.

Such information could steer help to trans students who report high rates of bullying and harassment, according to Cody Venzke, senior counsel for the Center of Democracy and Technology, a nonprofit based in Washington D.C. that focuses on technology policy.

You cant understand what you dont measure, but with any sensitive data, there are risks to the students and families youre collecting data on, said Venzke, who proposes the policy change..

Someone could collect that data for a legitimate purpose but then later on it is used for a different purpose, such as a state agency identify trans students and reporting it to Child Protective Services, Venzke said, pointing out that some states have passed laws that consider transgender care as child abuse.

That is the No. 1 risk that schools face when they try to be a responsible steward of students data, he said.

Parents Defending Education, a Virginia-based group that opposes LGBTQ education in schools, objected to the proposal, stating it would empower schools to actively question and engage with children on gender and sexual identification issues that fall outside of the purview of public schools and are matters to be dealt with exclusively by parents.

Jennie Knight, vice president of the Grand Rapids LGBTQ Healthcare Consortium, said collecting data on transgender youths is important at a time when people are ringing alarm bells about more people coming out.

Knight said she has a 9-year-old son who just finished third grade and she does not want anyone at school talking to him about sex right now.

But I do think he should learn about all the different kinds of families there are, Knight said.

Being able to talk about gender at an age when children developmentally notice differences between themselves and others is not harmful, said Jennifer Schwartz, behavioral program manager at Corner Health Center in Ypsilanti, which offers health services and support for young people.

It helps them learn who they are as people later on, Schwartz said.

In the absence of schools, Michigan counties have begun expanding surveys to include information on LGBTQ people in health reports used to identify community needs.

In the last four years, at least 11 of 83 counties have collected such information, but the number of LGBTQ respondents is still very low, which makes it hard to accurately represent the community.

Accurately representing the community not only makes people feel safer coming out, but it also helps health departments tailor their services to meet those peoples needs, said Maris Brummel, an epidemiologist for the Kent County Health Department.

In 2020, for the first time, Kent County included demographics on its LGBTQ community in a county health report that lays out its residents health status, needs and issues.

Of the people surveyed, 4 percent identified as LGBTQ and about 1 percent of them are transgender. The report found 6 percent of the countys surveyed middle schoolers and 8 percent of its high schoolers identify as lesbian, gay or bisexual. The report excluded information on transgender youths.

One barrier is that many LGBTQ males and non-binary people dont feel comfortable responding to the survey, Brummel said.

Eaton County, for instance, is among the counties in Michigan that dont include LGBTQ residents in their community health reports because so few people responded that they identify as LGBTQ, said Milea Burgstahler, the countys quality improvement coordinator.

Less than six people identified as LGBTQ in the survey of Eaton County, which has a population of about 109,000. Burgstahler said, we couldnt analyze the data to represent a sample that is representative of the population.

Estimates vary nationwide, but the percentage of people nationwide identifying as lesbian, bisexual, nonbinary, transgender has steady increased since Gallup began polling in 2012. The firm now estimates 7 percent of the public identifies as something other than straight.

In Michigan, the U.S. Census Bureau estimated in 2019 there are about 24,000 same-sex households, about 1.1 percent of Michigan couples. Nationwide, the rate is 1.5 percent.

The national wave of legislation involving trans youths is exacerbating mental health risks plaguing them, said Erin Knott, the executive director of Equality Michigan, the states largest LGBTQ advocacy group.

We have seen in Michigan an uptick in harmful rhetoric aimed at our trans and nonbinary youth, Knott said.

She works with The Trevor Project, a national suicide prevention and crisis intervention nonprofit for LGBTQ young people. Last year, its hotline received 6,200 calls from Michigan kids, Knott said.

That year, a national survey by The Trevor Project found that 42 percent of the 35,000 LGBTQ youths who were surveyedand over half of them being trans and nonbinary youthsseriously considered suicide within the prior year.

Social media is elevating more transgender roles models, but how safe a person feels depends on where they live, said Leisha Taylor, a bisexual woman in Hillsdale. Taylor said historically, religious and conservative communities like Hillsdale have not welcomed gender diverse people.

The words they have used to describe us are abomination and abhorrent, Taylor said.

Taylor noted recent controversies in Hillsdale targeting the LGBTQ community as a reason why friends and family who identify as transgender have to hide it because they dont feel safe coming out.

In May, one member of the Hillsdale Community Library Board suggested forbidding the library from buying books for people under age 18 that discuss sexual identity and gender identity.

Gender diverse people can become confused about their identity when their communities are not welcoming or lack representation of transgender people, according to Jay Dunn, a 38-year-old man who transitioned in his late 30s.

Dunn grew up in Galesburg, a small city in Kalamazoo County, and came out to his parents as a lesbian at age 17.

It was tough growing up there, said Dunn, adding he was one of three openly gay students at his high school and they were frequently bullied.

While Dunn identified as a lesbian because he liked girls, he said his adolescence was a confusing time and something always felt off. It was not until a family friend came out as transgender that Dunn realized his authentic self.

Today, Dunn is receiving hormone therapy and had his breasts removed. He says it is the happiest he has ever been, noting that his wife now says your confidence is through the roof.

The only thing I regret is not being able to start transitioning sooner, Dunn said.

One of the most effective methods of treating gender-associated distress is providing adolescents access to gender-affirming care, according to endocrinologist Daniel Shumer who founded the states first pediatric gender clinic at Motts Childrens Hospital in 2015.

Gender-affirming care was first founded in Germany in 1918, began in the United States in the late 1940s and was made available to adolescents in 2007.

There are three forms of gender-affirming care: puberty blocking medicine, hormone therapy and gender-confirmation surgery, like breast removal or implants.

Puberty blocking medicine is a non-invasive, reversible process that desensitizes the brain gland that releases puberty hormones and allows kids time and space to explore their gender identity, according to Shumer.

Natural puberty would pick up where it left off if a patient chooses to stop taking puberty blockers.

Hormone replacement therapy produces more testosterone or estrogen depending on the sex features a person wants expressed. Both forms of treatment cost thousands of dollars a year without insurance.

Shumer said transgender and nonbinary adolescents experience gender dysphoria, unease that a person may have because of a mismatch between their biological sex and their gender identity.

Children generally feel this discomfort around age 10 when they are about to hit puberty and their bodies change in ways that make them uncomfortable, according to Shumer. At that time, transgender children who are out start asking their parents about getting gender-affirming care.

Shumer said a vast majority of the kids who are distressed about puberty and receive treatment grow into happy, healthy, successful, well-adjusted adults.

They really feel like the treatment theyre getting is making a huge difference and its potentially life-saving for a lot of these young people, Shumer said.

Shumer said he was exposed to a pediatric gender clinic during his medical training and saw how helpful providing high quality care to transgender and gender diverse young people can be.

There was quite clearly a need for these services in Michigan, Shumer said, noting that when the clinic opened, he was getting referrals from all over the state and the clinic became very busy quite quickly.

Over time, Shumer said the number of referrals increased to 100 new patients each year and more adolescents between the ages of 10 and 18 were seeking care.

Its clear that in Michigan and across the country, young people are thinking more critically about gender identity and exploring gender identity is a normal process of adolescence, he said.

Before Shumers clinic opened, families like Roz Keiths often traveled out of state seeking such care. Keith is the board president of Stand With Trans, a nonprofit support group for transgender kids and families with transgender members.

Keith said she was getting transferred all over the place because Michigan did not have resources for transgender youths when her son Hunter Keith came out as a transgender male in 2012.

Hunter Keith said it took a year for him to be seen by a specialist who was based in Boston, Massachusetts and had a very long waiting list.

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Ostarine MK-2866 | Review, Alternatives,Side Effects and Results-Health News – Firstpost

Posted: July 19, 2022 at 2:00 am

It works by combining the androgen receptors in the body, which assists in lowering body fat and promoting muscular building.

Ostarine is a SARM (selective androgen receptor modulator) of the second generation, also known as Enobosarm or MK-2866. You are thus at the correct spot since this article will provide you with information on Ostarine and amazing Ostarine MK-2866 alternatives.

Ostarine is a specific sort of androgen receptor modulator (SARM). It works by combining the androgen receptors in the body, which assists in lowering body fat and promoting muscular building. It is a non-toxic substance with minimal adverse effects.

Therefore, let's go more into Ostarine; at the end of this section, you will be aware of all the essential facts and other facets associated with the use of this substance.

In an effort to prevent the problem, a concerted effort was undertaken to devise a realistic, safer alternative. SARMs represent the next generation of T-Boosting medications.

SARM is an acronym for selective androgen receptor modulators. SARM pharmaceuticals are anabolic chemicals intended to bind to androgen receptors.

SARM compounds are being studied by medical experts as a possible treatment for complicated conditions such as osteoporosis, cancer, sexual impairments, Alzheimer's disease, multiple sclerosis, and muscle wasting.

Ostarine MK-2866 and other SARMs are often utilized by athletes for performance enhancement, lean muscle growth, fat loss, a rapid recovery rate, and enhanced strength and endurance.

Ostarine and SARMs were believed to have much fewer negative effects than steroids. However, the reality is exactly the reverse.

Prior to discussing what Ostarine is, it is necessary todefine a SARM. Androgens are a class of sexual habitats. The most prominent are testosterone and estrogen.

These androgens exert their effects via proteins known as androgen receptors.

The multiple functions of your body's androgen receptors include developing muscular growth and strength.

The acronym SARM stands for selective androgen receptor modulator. This family of medicinal drugs modulates the behavior of androgen receptors. In other words, SARMs (Ostarine,Rad 140,Ibutamorenetc..) induce your DNA to alter, resulting in quicker, larger, and stronger muscular growth.

The word selective is a crucial component of the SARM concept. If anabolic steroids are blunt instruments, SARMs are scalpels. Steroids also bind and modify androgen receptors. However, they may bind elsewhere in the body, leading to acne, hair loss, prostate issues, etc. SARMs, on the other hand, target androgen receptors exclusively and do not bind anywhere else in the body.

In the 1990s, SARMs were produced by accident. As a result of exploring therapies for numerous malignancies and muscle-wasting disorders, such as those connected with AIDS, this incident occurred. James T. Dalton, a scientist, and professor researching prostate cancer therapy discovered the first ever.

Through this procedure, he found the first SARM, the chemical andarine. Its benefits on muscle development were amazing, and he focused nearly exclusively on that chemical.

Dalton spent the next many years perfecting it, and Ostarine was the outcome of this work. It would shortly enter clinical trials, where it would again exhibit its potential to increase lean muscle mass, but would not reach the desired outcomes in terms of curing cancer.

Immediately after this study, Ostarine would be accessible on the illegal market. While it is currently an experimental medicine undergoing various clinical studies, bodybuilders utilize it all over the globe. TheWorld Anti-Doping Agencycontinues to classify it as a restricted drug around the globe.

Ostarine has connected itself to the body's androgen receptor. When it combines, the receptors are designated to expand muscles more rapidly. The process of focusing muscle development modifies genes. This technique further enhances muscle development by boosting protein synthesis.

The functioning mechanism is related to the anabolism in which tiny molecules are split to generate a superior, more complex molecule. All of these actions need additional energy, therefore Ostarine functions as an external force.

This enables the body's protein to work harder, resulting in an increase in lean muscle mass during intense exercises.

Additionally, the supplement assists in enhancing endurance and energy for extended training sessions.

This is good for you if a fat-burning diet has left you feeling very exhausted. Consequently, your lost muscles recover rapidly via exercise. Your body's muscular mass activity also increased. Thus, your physique will seem slimmer and more refined.

Several distinct kinds of amino acids are contained in this medicine, according to certain sources. One of the amino acids contained in Ostarine is leucine.

Leucine was used by bodybuilders as a meal replacement supplement. It is excellent foraccelerating muscle recoveryand lowering lactic acid buildup after intense training sessions.

The bodybuilders who use Ostarine MK2866 to grow muscle say that this supplement provides them a tremendous edge over their rivals. It not only increases the intensity of their training but also promotes faster muscle recovery.

Ostarine is a non-toxic dietary supplement with minimal adverse effects. Some potential adverse effects include:

Some may have headaches at first use. If someone has this issue, he must reduce the dose. It is recommended to take aspirin before taking this supplement.

Some individuals reported experiencing nausea after ingestion. This occurs when estrogen levels are adjusted to modify the dosage of a drug inside the body.

Some individuals claim that following extended usage of large dosages, they get despondent. However, this state is only brief. If someone is seeing an increase in emotional problems, he should stop using this SARM.

Some users develop joint aches. Since this supplement is meant to develop muscle, this issue should occur naturally. If this issue causes you pain, you should avoid using it for at least one to three weeks. Until your joint discomfort disappears totally.

Some users report gastrointestinal discomfort. Which results in an abundance of weakness.

At the conclusion of the cycle, several individuals complain about their facial acne and hyperpigmentation.

Click Here to Order the Legal Ostarine Alternative [Osta 2866 CrazyBulk]

OSTA 2866 is a 100 percent natural dietary supplement that inundates the body with herbs and essential minerals that mimic the performance-enhancing and muscle-building capabilities of Ostarine MK-2866 without causing severe health effects. The dietary supplement enhances muscle development by increasing testosterone production, promoting muscular blood flow, boosting energy, and accelerating fat loss.

People who want rapid muscle growth in a couple of weeks could begin utilizing OSTA 2866, which replicates the controversial bodybuilding component Ostarine perfectly. As the Food and Drug Administration of the United States has not approved Ostarine, its replacement is the safest option.

CrazyBulk, a health and wellness company with over a decade of expertise in the industry, is the manufacturer of OSTA 2866. The company has sold over two million bottles abroad. It is a strong ergogenic aid that enhances power output at constant perceived effort levels and delays the onset of fatigue after strenuous physical activity.

Each serving of CrazyBulk's OSTA 2866 comprises scientifically effective doses of performance-enhancing chemicals and essential minerals, which together promote lean muscle development.

Reishi Fungus Extract

Reishi mushroomsare powerful adaptogens that boost the production of metabolic energy (ATP), increase physical strength, and speed up muscle recovery. Each serving of CrazyBulk's OSTA 2866 includes 200 milligrams of Reishi mushroom extract.

Cinnamon (30:1 Extract)

Cinnamon moderates the insulin response and decreases post-meal glucose spikes. This decreases the body's storage of sugar as fat. Each serving of CrazyBulk's OSTA 2866 includes 200 mg of cinnamon.

Fennel (4:1 Extract)

Fennel is a dietary item that supplies the body with the necessary levels of vitamin C. It acts as a supplement to combat weariness and exhaustion during activity. Each serving of CrazyBulk's OSTA 2866 includes 400 mg of fennel.

Southern Ginseng

Southern ginseng, a herbaceous climbing vine native to South and East Asia, enhances adrenal gland function during exercise in order to boost endurance and build strength. CrazyBulk's OSTA 2866 includes 550 mg of southern ginseng.

Salacia

The medicinal herb Salacia, which is native to India and Sri Lanka, enhances insulin sensitivity, boosts glucose metabolism, and promotes weight loss. The Salacia extract inside OSTA 2866 is responsible for its fat-burning effects. Each serving of CrazyBulk's OSTA 2866 includes 600 mg of Salacia.

Zinc (Zinc Citrate)

Zinc enhances muscular growth by boosting aerobic capacity, which measures the quantity of oxygen supplied to the muscles. A shortage of oxygen in the muscles may inhibit the ability to build muscle. The minerals also help in post-exercise tissue repair. OSTA 2866 from CrazyBulk includes 10 mg of the most bioavailable type of zinc, zinc citrate, in each dosage.

Magnesium (As Magnesium Oxide)

Magnesium improves exercise performance and promotes muscle development. Each serving of CrazyBulk's OSTA 2866 includes 35 mg of magnesium.

Click Here to Order the Legal Ostarine Alternative [Osta 2866 CrazyBulk]

Click Here to Order the Legal Ostarine Alternative [OstaBulk Brutal Force]

OstaBulk is a natural substitute for the now-prohibited SARM Ostarine MK28660.

It has the same results without negative side effects. It functions as an anabolic steroid and promotes muscular growth.

OstaBulk is made in the United States by Muscles Club Limited and distributed under the Brutal Force brand.

In the United Kingdom, Health Nutrition Limited owns the brand, Brutal Force.

Multiple products are available to meet the diverse needs of both professional and amateur bodybuilders. OstaBulk is 100% natural and fully safe to use.

It is formulated by combining numerous components. It encourages lean muscle development.

It is made and sold by well-known companies in the sector of dietary supplements.

B6 vitamin:

This product contains a substance that may help in the body's natural testosterone production. Additionally, it may assist in the decrease of recovery time and the enhancement of sleep habits. It may aid in muscle building and endurance.

D3 (calcium iodide):

Vitamin D3 from Ostabulk may help you restore the quality and strength of your muscular fibers. The recuperation period of bodybuilders is a drawback. This component may facilitate quicker recovery and enhanced muscle development.

K1 vitamin:

The quantity of vitamin K1 in the body affects muscular strength and performance. According to research, this element in Ostabulk may help maintain a high level of K1 in plasma and promote the development of enormous muscles.

Magnesium:

This substance comprises both magnesium citrate and magnesium oxide. This might assist in maintaining muscular flexibility and preventing cramping. This product's citrate content may improve magnesium digestion in the body.

Zinc Citrate

This product's zinc citrate may help boost the immune system. It may boost endurance and facilitate severe exercise.

D-Aspartic Acid (DAA):

According to the study, D-AA may stimulate the brain's hormone production. This hormone boosts the synthesis of testosterone throughout the body. This may contribute to the growth of stronger muscles.

Stinging Nettle Leaf:

This contributes to the development of muscles. According to research, it may boost muscle development naturally and is safe to consume.

Korean Red Ginseng Root Extract:

Multiple studies have shown that Korean Red Ginseng assists sportsmen and bodybuilders in exercise, bulking, and injury recuperation. It may also increase the body's endurance and energy levels.

Seed Extract of Fenugreek:

It has the ability to develop strength and endurance naturally and safely. It may also help in increasing the body's testosterone level, which may promote muscular building.

Citrate of Boron:

This ingredient in Ostabulk may improve muscular coordination. Additionally, it may assist in the growth of strong bones and the production of testosterone.

Black Pepper Fruit Extract with BioPerine:

The mineral BioPerine is produced from black pepper berries. According to a number of observational studies, it may aid in weight reduction and energy levels, and sportsmen and bodybuilders are fond of it.

Click Here to Order the Legal Ostarine Alternative [OstaBulk Brutal Force]

MK 2866's effects are comparable to those of anabolic steroids. However, it must be remembered that the medicine is in no way a steroid.

The comparison between the two is based on their capacity to interact with Androgen Receptors. However, in contrast to anabolic steroids, its propensity to bind to the AR is limited to those in muscles and bones and no other organ.

Due to its limiting nature, MK 2866 functions similarly to steroids but does not have the same adverse effects.

Ostarine is a banned dietary supplement for a variety of reasons. It aids muscle development and quality that may have been impaired by an autoimmune illness or cancer.

Regarding recreational usage, it is advantageous for both men and women with muscle-building or muscle-definition objectives.

It burns fat beautifully to reveal a lean, muscular figure and provides superhuman power to improve your training volume.

It is reasonable to presume that MK 2866 may inhibit your hormones like other medications in its class. However, its effects are not as suppressive as those of several widely used SARMs that alter hormone levels globally.

Despite this, the chemical might obliterate your natural testosterone levels, which you can subsequently address with a PCT.

Although Ostarine is less potent than the original steroids, we cannot say that it is completely devoid of adverse effects.

There are potential risks associated with the usage of MK 2866.

It is also banned in the USA.

Some of them may include:

In general, Ostarine's bulking effects as a performance-enhancing medication are noteworthy.

Due to the fact that it stimulates the process of muscle regeneration, the majority of individuals like to utilize it to experience enormous muscular increases.

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New treatment changing outlook for those with blood cancers – WBAL TV Baltimore

Posted: July 19, 2022 at 1:58 am

Ten percent of all diagnosed cancers in the United States are blood cancers, and they can be deadly. There are exciting new treatments and research happening in Baltimore that are giving patients hope."These therapies cure the patients that have no other treatment options. It's been a remarkable breakthrough," said Dr. Aaron Rapoport, of the University of Maryland School of Medicine.Cutting-edge technology will treat many types of cancers such as leukemia, lymphoma and myeloma. Traditional treatments include chemotherapy, radiation and stem cell therapy, but what if those treatments don't work?Now, there is an immunotherapy for aggressive blood cancers that is seeing remarkable results.Chip Baldwin, who has a big laugh and immense love for his grandchildren, thought it was the end when he was told in January 2018 that chemotherapy was no longer working to treat his lymphoma."This is Kyle, he's about 3 1/2 years old and he lives in Florida. (My) granddaughter Maple. She and her family live in Fells Point. And this is (my) granddaughter Rosemary and she's a doll, and they call me Pop-pop," Baldwin said.But Baldwin almost never met two of his grandchildren.Baldwin said he had difficulty "leaving (his wife), Angela, and leaving the family, trying to figure out how they're going to get by."He was out of options, or so he thought. Not willing to give up, his wife, Angela Baldwin, began researching and came across a promising new treatment."(It was) probably the last treatment that I could have received. Had I not received it and had it not been positive to put me in remission, I probably wouldn't be talking to you today," Baldwin said.The treatment he received had just been approved by the U.S. Food and Drug Administration months earlier. It's called "CAR T-cell Therapy," and it uses the patient's own, re-engineered immune cells to kill cancer. Rapoport helped pioneer the development of CAR T-cell at the University of Maryland Greenebaum Comprehensive Cancer Center. Baldwin was just the second patient to receive it."The notion that one could perhaps harness the immune system, or educate the immune system, to better protect us from cancer, but also to recognize and fight against cancer, has been a goal for decades, centuries really," Rapoport said.It appears that goal has been reached. Here's how it works: The medical team extracts immune cells, called T-cells, out of the patient's blood. The cells are sent to a special lab in California, where scientists change the cells' DNA to put receptors on them called "CAR" - Chimeric Antigen Receptors. They enable the immune cells to recognize, hunt down and kill the cancer cells. The California lab then sends the now-re-engineered immune cells back to the Greenebaum Comprehensive Cancer Center."These are CAR T-cells growing in the flask here. These are CAR T-cells that were made in the lab," said Dr. Djordje Atanackovic, a hematology oncologist at the University of Maryland Medical Center.Under a microscope, spots on a cancer cell can be seen that are the killer CAR T-cells. "You could use these right now to treat a patient," Atanackovic said.For the final step, patients are admitted to the hospital and the medical team puts the T-cells back into the patient, where the cells multiply by the millions and destroy the cancer. For Baldwin, that was the day after Easter 2018."Then, about four months later, they determined that all the cancer cells had died, " Baldwin said."Being told that their scans are negative is a really overwhelming experience -- not just for the patients, but for the families and also the nurses and physicians, the team members that are involved in their care," Rapoport said.When looking at CT scan images of two other lymphoma patients, black areas seen on one of the images is extensive cancer. The other image shows the same patient after CAR T-cell therapy, and the cancer is gone. Right now, CAR T-cell Therapy is approved to treat aggressive blood cancers Lymphoma, B-cell Leukemia and Myeloma. But Atanackovic believes that's just the beginning."I'm pretty optimistic that, in 10 years from now, we'll have novel immunotherapies that we can't even imagine at this point for everyone, or at least most of our patients with cancer," Atanackovic said.Four years after his treatment, Baldwin is still in remission. He doesn't like the word "cure" because he's afraid it's bad luck. The word Baldwin keeps saying is: "'Unbelievable.' And even to this day, I kind of can't believe I'm in remission and I'm able to live my life. Since then, I've had two grandchildren and it's been wonderful. Had it not been for the university and the treatment, I would never have seen the two kids."So far, 250 patients have been treated with CAR T-cell Therapy at the University of Maryland, but it's not perfect and researchers are still working to improve it. The success rate for patients with aggressive lymphoma, for example, is 50% and some patients have side effects, like flu-like symptoms, so they typically stay in the hospital for days or even weeks.Many may wonder whether this is covered by insurance. The answer is yes. Keep in mind, right now, it is approved by FDA as a second-line therapy, so patients have to try a different treatment first. But, immunotherapy like CAR-T is the future of cancer treatment.

Ten percent of all diagnosed cancers in the United States are blood cancers, and they can be deadly. There are exciting new treatments and research happening in Baltimore that are giving patients hope.

"These therapies cure the patients that have no other treatment options. It's been a remarkable breakthrough," said Dr. Aaron Rapoport, of the University of Maryland School of Medicine.

Cutting-edge technology will treat many types of cancers such as leukemia, lymphoma and myeloma. Traditional treatments include chemotherapy, radiation and stem cell therapy, but what if those treatments don't work?

Now, there is an immunotherapy for aggressive blood cancers that is seeing remarkable results.

Chip Baldwin, who has a big laugh and immense love for his grandchildren, thought it was the end when he was told in January 2018 that chemotherapy was no longer working to treat his lymphoma.

"This is Kyle, he's about 3 1/2 years old and he lives in Florida. (My) granddaughter Maple. She and her family live in Fells Point. And this is (my) granddaughter Rosemary and she's a doll, and they call me Pop-pop," Baldwin said.

But Baldwin almost never met two of his grandchildren.

Baldwin said he had difficulty "leaving (his wife), Angela, and leaving the family, trying to figure out how they're going to get by."

He was out of options, or so he thought. Not willing to give up, his wife, Angela Baldwin, began researching and came across a promising new treatment.

"(It was) probably the last treatment that I could have received. Had I not received it and had it not been positive to put me in remission, I probably wouldn't be talking to you today," Baldwin said.

The treatment he received had just been approved by the U.S. Food and Drug Administration months earlier. It's called "CAR T-cell Therapy," and it uses the patient's own, re-engineered immune cells to kill cancer.

Rapoport helped pioneer the development of CAR T-cell at the University of Maryland Greenebaum Comprehensive Cancer Center. Baldwin was just the second patient to receive it.

"The notion that one could perhaps harness the immune system, or educate the immune system, to better protect us from cancer, but also to recognize and fight against cancer, has been a goal for decades, centuries really," Rapoport said.

It appears that goal has been reached. Here's how it works: The medical team extracts immune cells, called T-cells, out of the patient's blood. The cells are sent to a special lab in California, where scientists change the cells' DNA to put receptors on them called "CAR" - Chimeric Antigen Receptors. They enable the immune cells to recognize, hunt down and kill the cancer cells. The California lab then sends the now-re-engineered immune cells back to the Greenebaum Comprehensive Cancer Center.

"These are CAR T-cells growing in the flask here. These are CAR T-cells that were made in the lab," said Dr. Djordje Atanackovic, a hematology oncologist at the University of Maryland Medical Center.

Under a microscope, spots on a cancer cell can be seen that are the killer CAR T-cells.

"You could use these right now to treat a patient," Atanackovic said.

For the final step, patients are admitted to the hospital and the medical team puts the T-cells back into the patient, where the cells multiply by the millions and destroy the cancer.

For Baldwin, that was the day after Easter 2018.

"Then, about four months later, they determined that all the cancer cells had died, " Baldwin said.

"Being told that their scans are negative is a really overwhelming experience -- not just for the patients, but for the families and also the nurses and physicians, the team members that are involved in their care," Rapoport said.

When looking at CT scan images of two other lymphoma patients, black areas seen on one of the images is extensive cancer. The other image shows the same patient after CAR T-cell therapy, and the cancer is gone.

Right now, CAR T-cell Therapy is approved to treat aggressive blood cancers Lymphoma, B-cell Leukemia and Myeloma. But Atanackovic believes that's just the beginning.

"I'm pretty optimistic that, in 10 years from now, we'll have novel immunotherapies that we can't even imagine at this point for everyone, or at least most of our patients with cancer," Atanackovic said.

Four years after his treatment, Baldwin is still in remission. He doesn't like the word "cure" because he's afraid it's bad luck.

The word Baldwin keeps saying is: "'Unbelievable.' And even to this day, I kind of can't believe I'm in remission and I'm able to live my life. Since then, I've had two grandchildren and it's been wonderful. Had it not been for the university and the treatment, I would never have seen the two kids."

So far, 250 patients have been treated with CAR T-cell Therapy at the University of Maryland, but it's not perfect and researchers are still working to improve it. The success rate for patients with aggressive lymphoma, for example, is 50% and some patients have side effects, like flu-like symptoms, so they typically stay in the hospital for days or even weeks.

Many may wonder whether this is covered by insurance. The answer is yes. Keep in mind, right now, it is approved by FDA as a second-line therapy, so patients have to try a different treatment first. But, immunotherapy like CAR-T is the future of cancer treatment.

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New treatment changing outlook for those with blood cancers - WBAL TV Baltimore

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How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more – KYMA

Posted: July 19, 2022 at 1:57 am

(CNN) - Shrooms, Alice, tweezes, mushies, hongos, pizza toppings, magic mushrooms -- everyday lingo for psychedelic mushrooms seems to grow with each generation. Yet leading mycologist Paul Stamets believes it's time for fans of psilocybin mushrooms to leave such childish slang behind.

"Let's be adults about this. These are no longer 'shrooms.' These are no longer party drugs for young people," Stamets told CNN. "Psilocybin mushrooms are nonaddictive, life-changing substances."

Small clinical trialsthat have shown thatone or two doses of psilocybin, given in a therapeutic setting, can make dramatic and long-lasting changes in people suffering from treatment-resistant major depressive disorder, which typically does not respond to traditional antidepressants.

Based on this research, the US Food and Drug Administration has described psilocybin as abreakthrough medicine, "which is phenomenal," Stamets said.

Psilocybin, which the intestines convert into psilocin, a chemical with psychoactive properties, is also showing promise in combatingcluster headaches,anxiety,anorexia,obsessive-compulsive disorderand various forms ofsubstance abuse.

"The data are strong from depression to PTSD to cluster headaches, which is one of the most painful conditions I'm aware of," said neurologist Richard Isaacson, director of the Alzheimer's Prevention Clinic in the Center for Brain Health at Florida Atlantic University.

"I'm excited about the future of psychedelics because of the relatively good safety profile and because these agents can now be studied in rigorous double-blinded clinical trials," Isaacson said. "Then we can move from anecdotal reports of 'I tripped on this and felt better' to 'Try this and you will be statistically, significantly better.'"

Classic psychedelics such as psilocybin and LSD enter the brain via the same receptors as serotonin, the body's "feel good" hormone. Serotonin helps control body functions such as sleep, sexual desire and psychological states such as satisfaction, happiness and optimism.

People with depression or anxiety often have low levels of serotonin, as do people with post-traumatic stress disorder, cluster headaches, anorexia, smoking addiction and substance abuse. Treatment typically involves selective serotonin reuptake inhibitors, or SSRIs, which boost levels of serotonin available to brain cells. Yet it can take weeks for improvement to occur, experts say, if the drugs even work at all.

With psychedelics such as psilocybin and LSD, however, scientists can see changes in brain neuron connectivity in the lab "within 30 minutes," said pharmacologist Brian Roth, a professor of psychiatry and pharmacology at the University of North Carolina at Chapel Hill.

"One of the most interesting things we've learned about the classic psychedelics is that they have a dramatic effect on the way brain systems synchronize, or move and groove together," said Matthew Johnson, a professor in psychedelics and consciousness at Johns Hopkins Medicine.

"When someone's on psilocybin, we see an overall increase in connectivity between areas of the brain that don't normally communicate well," Johnson said. "You also see the opposite of that -- local networks in the brain that normally interact with each other quite a bit suddenly communicate less.

"It creates a "very, very disorganized brain," ultimately breaking down normal boundaries between the auditory, visual, executive and sense-of-self sections of the mind -- thus creating a state of "altered consciousness," said David Nutt, director of the Neuropsychopharmacology Unit in the Division of Brain Sciences at Imperial College London.

And it's that disorganization that is ultimately therapeutic, according to Nutt: "Depressed people are continually self-critical, and they keep ruminating, going over and over the same negative, anxious or fearful thoughts.

"Psychedelics disrupt that, which is why people can suddenly see a way out of their depression during the trip," he added. "Critical thoughts are easier to control, and thinking is more flexible. That's why the drug is an effective treatment for depression."

There's more. Researchers say psychedelic drugs actually help neurons in the brain sprout new dendrites, which look like branches on a tree, to increase communication between cells.

"These drugs can increase neuronal outgrowth, they can increase this branching of neurons, they can increase synapses. That's called neuroplasticity," Nutt said.

That's different from neurogenesis, which is the development of brand new brain cells, typically from stem cells in the body. The growth of dendrites helps build and then solidify new circuits in the brain, allowing us to, for example, lay down more positive pathways as we practice gratitude.

"Now our current thinking is this neuronal outgrowth probably doesn't contribute to the increased connectivity in the brain, but it almost certainly helps people who have insights into their depression while on psilocybin maintain those insights," Nutt said.

"You shake up the brain, you see things in a more positive way, and then you lay down those positive circuits with the neuroplasticity," he added. "It's a double whammy.

"Interestingly, SSRIs also increase neuroplasticity, a fact that science has known for some time. But in a 2022 double-blind phase 2randomized controlled trialcomparing psilocybin to escitalopram, a traditional SSRI, Nutt found the latter didn't spark the same magic.

"The SSRI did not increase brain connectivity, and it actually did not improve well-being as much as psilocybin," Nutt said. "Now for the first time you've got the brain science lining up with what patients say after a trip: 'I feel more connected. I can think more freely. I can escape from negative thoughts, and I don't get trapped in them.' "Taking a psychedelic doesn't work for everyone, Johnson stressed, "but when it works really well it's like, 'Oh my god, it's a cure for PTSD or for depression.' If people really have changed the way their brain is automatically hardwired to respond to triggers for anxiety, depression, smoking -- that's a real thing.

"How long do results last? In studies where patients were givenjust one doseof a psychedelic "a couple of people were better eight years later, but for the majority of those with chronic depression it creeps back after four or five months," Nutt said.

"What we do with those people is unknown," he added. "One possibility is to give another dose of the psychedelic -- we don't know if that would work or not, but it might. Or we could put them on an SSRI as soon as they've got their mood improved and see if that can hold the depression at bay.

"There are all sorts of ways we could try to address that question," Nutt said, "but we just don't know the answer yet."

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How psilocybin, the psychedelic in mushrooms, may rewire the brain to ease depression, anxiety and more - KYMA

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Is the ISS an Ideal Place to Grow Billions of Stem Cells? Scientists Seem to Think So – iTech Post

Posted: July 19, 2022 at 1:56 am

Stem cell research has been considered a potentially thriving resource for a wide range of therapies for such diseases as Parkinson's Disease and heart disease. This is due to stem cells' ability to generate close to any type of cell in the body and their exceptional adaptability that make them effective tools to discover new treatments to fight deadly diseases.

While stem cell research has grown by leaps and bounds, there have been barriers to reaching this objective, particularly in producing an enormous amount of stem cells to realize these therapies. To overcome these, scientists conducted experiments on stem cells aboard the International Space Station. Why the ISS? This is because microgravity conditions in the ISS offer an ideal environment to explore new scientific methods and approaches, allowing researchers to hurdle logistic barriers to mass production of stem cells, potentially in the billions.

This is because patients may need billions of cells as the specific treatment may require. While on Earth, gravity makes it challenging to produce these cells in massive quantities, which these treatments need. As such, stem cell research and mass production is deemed more effective in space, with the ISS as an ideal place to make that happen.

Researchers at Cedars-Sinai Medical Center in Los Angeles has taken a giant leap to realize producing a type of stem cell in massive batches, a press announcement said. This stem cell can generate any type of cell in the bodytha can be used to make treatments for a number of diseases. One of its researchers, Dhruv Sareen, donated his own stem cells for the stem cell experiment in the ISS. Sareen's cells arrived aboard a SpaceX resupply mission - the SpX-25 dragon cargo mission - to the ISS over the weekend.

The experiment is the latest research project that involves shooting stem cells into space. Some, like this one, aim to overcome the terrestrial difficulty of mass producing the cells. Others explore how space travel impacts the cells in the body. And some help better understand diseases such as cancer.

Read Also:Stem Cell Transplant Sees Mice Regaining Memory And Learning Capabilities

In the previous stem cell research projects, the U.S., China and Italy brought to space various types of stem cells, including research on the effects of microgravity on cell-level heart function by Dr. Joseph Wu of Stanford University, director of the Stanford Cardiovascular Institute. Wu led a series of programs onn of Washing space-based stem cell research last year.

Earth-based applications have so far been limited.

Currently, the U.S. Food and Drug Administration (FDA) has only approved stem cell products that carry blood-forming stem cells originating from umbilical cord blood to treat lymphoma. Stem cell treatments derived from stem cells sent to space have yet to be approved, according to Jeffrey McMillan of Washington University in St. Louis, Missouri.

The only stem cell-based products approved by the Food and Drug Administration contain blood-forming stem cells from umbilical cord blood for patients with blood disorders such as certain cases of lymphoma. There are no approved therapies using the kind of stem cells being sent to space or others derived from them, according to biomedical engineering expert Jeffrey Millman of Washington University in St. Louis, Missouri in an Interesting Engineering report.

McMillan noted that with present technology, even with FDA approval, capacity to manufacture these treatments is unattainable.

This is because large bioreactors are needed to produce stem cells on Earth. And these cells need to be stirred vigorously, so they don't stick together or precipitate to the bottom of the tank. The stirring process could also damage the cells. In microgravity, no such force is exerted on the cells, thus they are able to grow using a different approach.

The Cedars-Sinai research team sent a shoebox-sized container holding pluripotent stem cells for their NASA-funded experiment on the ISS. The container holds pumps and chemical solutions needed to keep the stem cells alive for four weeks, the Interesting Engineering report further said. The same experiment will be carried out on Earth for comparison. In about five weeks, the box sent to space will be brought back to Earth through the same SpaceX capsule it was sent to space on. The mission will help scientists directly evaluate results in space and on Earth in a short timeframe. This will offer valuable new insight that could help launch a burgeoning field of medical research.

Related Article: Stem Cell Therapy: Miracle Cure Discovered For Girl With Cerebral Palsy

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Is the ISS an Ideal Place to Grow Billions of Stem Cells? Scientists Seem to Think So - iTech Post

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UM-Dearborn graduate hopes to make it to space – Dearborn Press and Guide

Posted: July 19, 2022 at 1:56 am

Samantha Snabes has wanted to be an astronaut for so long she doesnt remember a time when that wasnt the goal. Its not a totally unique childhood dream, of course, but Snabes has proved durable.

Now 41, she still very much wants to go to space, and in fact, has measured many life choices against whether they can help her get there. That focus has led her to do all kinds of bold things, starting from an early age. When she was 8 years old, she went to Space Camp, and after she got home, she cross referenced the astronaut directory in one of the take-home brochures with the white pages, calling up any astronauts with Michigan phone numbers. A few days later, Tony England, a veteran of the Apollo and Space Shuttle era and the now-retired dean of UM-Dearborns College of Engineering and Computer Science, left her a voicemail. It led to a memorable meeting between the two and some practical advice: I asked him what I needed to do to become an astronaut, and he said go to college.

Snabes held tight to Englands advice, but getting to college wasnt going to be straightforward. Aside from two aunts, no one in her family had a college diploma, and she was going to have to get creative to find the financial resources for college. The thing she had going for her was she was a standout student: Snabes was the valedictorian of her class and Wayne-Westlands Senior of the Year. So using money she saved from grooming dogs and cleaning horse stalls, she sent in her college applications. She got in almost everywhere she applied including Cornell. She assumed the admissions would come with offers of financial support, but the only place offering a scholarship was a college in Missouri. Her grandparents encouraged her to go for it, and after graduation, she packed up her things and headed to Springfield.

Snabes remembers many things about college being a struggle. She never had money for the current editions of textbooks, so she got by with older versions and loaners from the library. Often the reason her grades were so erratic was her out-of-date books literally didnt contain the required reading.

I think the culture is a lot different now, but I dont think it even really occurred to me to ask for help, Snabes said. I didnt have the resources and it felt like there was a stigma around that. Everyone else had their laptops, the right books, and seemed to know all these things that I didnt. I think its just sort of who I am, but I tried to figure things out on my own and push my way through it.

Despite the challenges, Snabes ultimately leveraged a lot of credits she earned there on scholarship into a transfer to UM-Dearborn. Continuing her education meant taking out lots of student loans, and like many first-gen students, she got tripped up navigating the conventions of the university system. She remembers that when she first transferred, someone encouraged her to pick a major and she didnt even know what a major was. She said astrophysics, one the university didnt offer, and then chose Biology based on someones suggestion that it might be a good fit given her love of science. Knowing of her ultimate dream, one of her professors suggested she should try to get some research experience, and she found a spot doing bench work in a start-up at a UM-Ann Arbor lab that was working with stem cells.

She half-jokingly says she was the janitor of the lab team, because her entry-level spot meant she did a lot of cleaning and prep work. But Snabes really shined in the lab. Her particular role involved using specialized hardware to grow stem cells, and she viewed keeping them alive as a personal challenge. Often she would drive back and forth between Detroit and Ann Arbor twice a day just to check on my cells, and her lab notebooks from that time are decorated with doodles of Thanksgiving turkeys and Christmas trees. At one point, their team set a record for keeping cells alive and regenerating in the device they were testing for more than a year. In fact, Snabes played a crucial part in that success. When she joined the team, the project was in a Phase II trial, and they were facing some challenges with lower-than-expected cell counts. One day, she asked if the trouble they were having keeping the cells alive might have something to do with the silver in the felt matrix they were growing them on. One of the investigators asked what she was thinking and she explained she remembered from her days making Halloween costumes for her younger siblings that felt often contains a silver ion, which gives it some antimicrobial properties. Ultimately it led to a discovery that the team had been unknowingly using off-the-shelf hobby-grade felt that did in fact contain silver. When they switched to medical grade, the cells took off, and so did the then-stalled project.

Snabes prowess in the lab ultimately led to her getting her name on the patent and another big opportunity. The start-up team had made rights to the technology available so others could build on the work, and the supervisor whom Snabes worked mostly closely with happened to be a serial entrepreneur. One day, the two went out to lunch and he asked if shed be interested in using the technology to start a company. The idea, hatched in a Korean restaurant in an Ann Arbor strip mall, eventually grew into Bioflow, which they launched in 2006. Over the next few years, they built up a client roster for their cell culture systems, but for a variety of reasons, selling the company became a better proposition than continuing to build it. She said looking back, they didnt get the best deal, but it allowed them to pay off their debts and get a fresh start with other opportunities.

For all of Snabes talents, instincts, and worth ethic in the lab, it was still just a means to an end in some ways. Getting into the astronaut program was still on her mind, and she was still making unconventional decisions to get there. During her time at UM-Dearborn, she had applied several times toNASAs Microgravity University, a program where undergraduates get to conduct experiments in a low-gravity environment. The highlight is a chance to ride in the Vomit Comet NASAs modified KC-135 aircraft that flies to 33,000 feet and then sharply nose dives for 30 seconds so passengers can experience something very close to weightlessness. Snabes caught NASAs attention with her first pitch: A blood clotting experiment that proposed using herself as a test subject. The advisers wrote back they couldnt sanction a project where she cut herself, and she wouldnt have sufficient time for the blood to clot anyway. But they loved her inventiveness and encouraged her to assemble another student team and apply again. The second time, she and her group from UM-Dearborn got in. But then federal funding snags delayed their scheduled trip in the Vomit Comet. That was a big deal, because Snabes was set to graduate and the program was only for undergrads. So she postponed her graduation, enrolling in enough classes to complete a Psychology minor. Additional student loan debt was more than worth the chance to fly.

Snabes ride in the Vomit Comet stands out as one of the highlights of her life. The photo of her, arms across her chest, somersaulting in the air, a relaxed smile on her face, is still her LinkedIn profile picture. Its worth mentioning that many people dont have such a good time. The Vomit Comet is so named because most people get violently nauseous when their body is suddenly propelled into near weightlessness. (For Snabes, that didnt happen until the celebratory meal afterward in which she says she ate way too many Chinese donuts.) The reason why the moment is still so important to her is straightforward enough: Given the competitiveness of the astronaut program, she knows she might not ever get in, and spinning weightlessly for a few seconds might be the closest she ever gets to space. The mental images of it all are still thrilling and vivid, exactly the feeling you have when youre flying in a dream. Only for Snabes, she experiences it with the realness of memory.

The experience also broke open a new series of opportunities. Snabes didnt know it at the time, but NASA was looking to recruit a couple people from the program to advocate on Capitol Hill about the value of the space program to regular citizens. She was happy to do it, and in the course of that work, she learned that a life sciences group at NASAs Johnson Space Flight Center needed a strategist ideally, a hip, under 30-something, who was a successful entrepreneur, had recently exited a company, had an MBA, and is passionate about space. Having recently started an MBA through UM-Dearborns online program, Snabes resume checked all the boxes, and in the end, she didnt even have to formally interview for the job. Once she had an in at NASA, other dominos started to tumble. Her job description at the agency was so loose, it gave her carte blanche to explore almost anything that sounded interesting to her. More importantly, she was finally fully amongst her people engineers, scientists and innovators who could talk all day and all night about big ideas and how they could change the world. Her volunteer time with Engineers Without Borders (EWB) was particularly formative, and through contacts with EWB and NASA, she finally got a chance to do something she never had the money to do: travel. As the social entrepreneur in residence for NASA headquarters, she traveled to Rwanda, Nicarauga and Mexico, exploring opportunities for the agency to do more social impact work. Looking back, it was a big turning point. What I realized is that we spend a lot of time and money trying to get resources into countries, and all these brilliant people from NASA were training people on whatever solutions we had, she says. But then Id see abandoned mounds of medical equipment that were the wrong voltage or couldnt be maintained sitting outside of a hospital. For Snabes, it seemed like there had to be a better way.

Around this time, Snabes and some like-minded friends and colleagues were getting really into something that could be part of that better way. Many of the patents on key parts of 3D printing technology were expiring, allowing researchers and entrepreneurs to build on the hardware in new ways. She was particularly interested in the idea of open-source 3D printing a paradigm in which the designs, software and printing technology could be deployed inexpensively to people, allowing communities to manufacture solutions for real problems. Enabling people to make their own things at lower costs was the exact antithesis to the bigger budget aid strategies Snabes had seen falter at times. The only problem was the technology at the time was limited, particularly by size: Inexpensive 3D printers were still pretty small and could only print small things. People would be really into the idea, but then theyd ask to see an example of something you could make, and inevitably someone would have something small, like an iPhone case or a Yoda head. They were still a ways away from being able to print things folks told her they were interested in, like limb prosthetics, birthing stools, composting toilets, and tools, to name a few.

Snabes realized theyd have to literally start thinking bigger. A larger printer could print larger, more useful stuff, and hours and hours of conversations with her friends and colleagues eventually coalesced around an aspirational goal to design and build a large-format 3D printer the size of a toilet for under $10,000. At the time, she said she didnt see it as starting her next company, and in fact, she shopped the idea around at NASA and EWB first, thinking they might go for it. When it didnt find a home with either, they scored $40,000 to build a prototype, which they debuted at SXSW at the Start-up Chile tent in 2013. A writer from TechCrunch was one of the first to see it demoed and put it onthe front page of the website. In less than two days, their Kickstarter campaign was fully funded.

With the spike of unexpected interest, Snabes and her co-founder dove right into starting the business. Nowre:3Dships its large-format Gigbot printers all over the world, including a new model that can print directly from plastic waste. For every hundred they sell, they also give one away to a person or group using it for social good. Their website is full of interesting testimonials. Theres aNigerian engineer using his Gigabot to develop new filament technologyand spur micro-manufacturing. A Kenyan charity is printing parts torepair medical equipment and water distribution infrastructure. In Portland, a nonprofit is using theirs to make some prettyepic custom costumes for kids in wheelchairs.

Though re:3D has garnered a ton of attention and goodwill, Snabes is clear that the business is still firmly in the start-up phase. Competition for large-format printing has grown since they started the business, and recruiting investors for a company devoted to a social mission is a different endeavor than if they were just trying to make money. Were definitely not a high-growth company, so whether or not you see us as successful depends, I guess, on how you measure success, Snabes says. But she says it never occurs to her to doubt the mission, and feels thankful that all the unexpected plot twists in her life have led her here. I recognize that as a woman who didnt have a ton of financial resources to draw on and who didnt grow up with an expectation to go to college, things could be working out differently. Now, Ive had the chance to start two companies, and I basically get to get up everyday and do whatever I want. Thats incredibly rare, and Im really humbled that thats my life right now.

She also hasnt given up on space, and is still doing everything she can to make herself an attractive astronaut candidate. Its completely possible that given the current interest in long-range space travel, experiments with 3D-printing could well be her ticket there. And though re:3D can feel all-consuming, she still makes time to serve as a major in Mississippis Air National Guard. She enlisted 13 years ago on her lunch break at NASA partly to help pay bills, partly to make her application to the astronaut program stronger. But its since turned into a big part of her life. There are lots of stereotypes about the Guard, she says, but for her, its another community of problem solvers who ultimately want to help people. Whether its the Guard, or her 3D-printing work, or the sum of all her adventures thats the difference-maker this time, she figures she has one more good shot before shes too old to be an astronaut. However it shakes out, her hustle has already fueled a wild ride.

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Testosterone Therapy Improves Erectile Function and Libido in …

Posted: July 11, 2022 at 2:51 am

Curr Opin Urol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as:

PMCID: PMC5649360

NIHMSID: NIHMS910261

aBaylor College of Medicine, Houston, TX

aBaylor College of Medicine, Houston, TX

bScott Department of Urology, Baylor College of Medicine, Houston, TX

cCenter for Reproductive Medicine, Baylor College of Medicine, Houston, TX

bScott Department of Urology, Baylor College of Medicine, Houston, TX

aBaylor College of Medicine, Houston, TX

bScott Department of Urology, Baylor College of Medicine, Houston, TX

cCenter for Reproductive Medicine, Baylor College of Medicine, Houston, TX

Erectile dysfunction (ED) and decreased libido are common complaints in the older male population. Recent studies have elucidated the role testosterone therapy (TTh) can play in men with low testosterone levels. The aim of this review is to provide an overview of these findings and the utility of TTh. We specifically examine the role of TTh on erectile function, co-administration with phosphodiesterase type 5 (PDE5) inhibitors, and libido.

Recent publications suggest that TTh improves mild ED, though may be less useful in men with more severe ED. In men unresponsive to PDE5 inhibitors and with mild ED, TTh can further improve erectile function. Testosterone therapy has also shown consistent benefit in improving libido in men with low testosterone levels at baseline, with no additional improvements once testosterone levels are normalized.

The available literature supports a role for TTh in men with low testosterone levels, ED, and low libido, with symptomatic improvement in these men.

MeSH Keywords: Testosterone, Erectile Function, Phosphodiesterase 5 Inhibitors, Hypogonadal men

Multiple longitudinal studies have observed that as men age, they experience a decline in total serum testosterone beginning in the third decade of life [1, 2]. By age 70, 30% of men will have low testosterone levels [2]. The symptoms of low testosterone include decreased libido, erectile dysfunction (ED), decreased energy, depressive symptoms, and fatigue [3]. These symptoms can be frustrating to men, and can be at least partially reversed with testosterone therapy (TTh). In this review, we summarize the recent literature examining the relationship between low serum testosterone levels, ED, and decreased libido.

To identify articles for this review, the following search terms were used in Medline: testosterone, testosterone replacement therapy, erectile dysfunction, and libido. Relevant and recent articles were identified and presented in this review. Articles published within the last 18 months were prioritized in this review.

ED affects 1 in 5 men, with this frequency increasing with age and the prevalence of co-morbidities [4, 5]. The National Institute of Health (NIH) defines ED as the inability to achieve or maintain an erection that is satisfactory for sexual performance [6]. Subjective erectile function can be assessed using validated questionnaire metrics including the international index of erectile function (IIEF) with the erectile function domain (IIEF-EF) being the most specific for assessing ED. The IIEF-EF consists of 6 questions that inquire about frequency and hardness of erections, ability to penetrate during intercourse, ability to maintain an erection during intercourse, ability to maintain an erection to completion of intercourse, and confidence in a mans ability to get and maintain an erection [7]. The severity of ED is then classified as mild, mild to moderate, moderate, and severe dysfunction. The IIEF-EF is often used in studies to trend changes in erectile function, with a change of 2 IIEF-EF points being clinically significant for men with mild ED. The minimal clinically important differences (MCID) for moderate and severe ED are a change of 5 and 7 IIEF-EF points, respectively [8].

Erection requires a combination of vascular, neurologic, psychologic, and hormonal factors. Erections are initiated when nitric oxide and other neuroendocrine factors induce relaxation of the smooth muscles of the cavernous arteries and tissues resulting in increased penile blood inflow. As the corpus cavernosum fills with blood, the veins that drain the corpus cavernosum are compressed, resulting in maintained turgidity [9]. This initial release of nitric oxide is mediated in part by testosterone [10]. While evaluating neurologic, vascular, and psychologic factors can be difficult during a clinical visit, a hormonal etiology of ED can easily be assessed by measuring morning serum testosterone levels. The evaluation of testosterone levels in men with ED is recommended by the European Association of Urology guidelines and is indicated in select men with ED per American Urology Association guidelines [11, 12].

Numerous studies have examined the relationship between testosterone levels and erectile function. In cross-sectional studies, men with low testosterone (defined by the US Food and Drug Administration as levels less than 300 ng/dL) have a greater prevalence of ED when compared to men with normal testosterone levels [1315]. Studies have observed that men who have been placed on androgen deprivation therapy (ADT) for prostate cancer have a dramatic reduction in erectile function with a decrease in testosterone levels [1618]. Finally, numerous randomized controlled trials (RCTs) have demonstrated that erectile function improves when testosterone is given to men with low testosterone levels [1924].

In the past few years, several studies have shown that testosterone levels and erectile function are positively correlated. The recently published Testosterone Trials a set of RCTs of 790 men with late onset hypogonadism randomly assigned to either testosterone gel or placebo demonstrated that after 1 year of treatment that men who used testosterone gel had an IIEF-ED score 2.64 points [95% Confidence Interval (CI): 1.06 4.02] greater than men who had been assigned to the placebo arm [24]. It is important to note that men enrolled in this study on average had moderate ED, and so this improvement in erectile function was not considered clinically significant.

In early 2017, Corona et al. performed meta-analysis of 14 RCTs that studied the effect of TTh on erectile function in men with late onset hypogonadism, and compared pre- and post-IIEF scores [25]. Overall, when compared to placebo, TTh provided only a modest improvement in IIEF-EF, as the mean difference between groups was 2.31 points. The mean change in IIEF-EF, however, was greater when data were stratified by baseline testosterone level. In primary studies using a testosterone threshold <8 nM (231 ng/dL), IIEF-EF increased by 2.95 points, whereas in primary studies with testosterone threshold of <12 nM (346 ng/dL), only a 1.47 point increase in IIEF-EF was observed [25]. Given that a greater improvement in erectile function was observed in studies using a lower testosterone threshold, this supports the theory that once a threshold of normal testosterone level is achieved, higher testosterone levels do not further improve erectile function [26]. This definitive study by Corona et al. also suggests that TTh may be a useful monotherapy in men with mild ED.

Numerous studies have found that phosphodiesterase type 5 (PDE5) is upregulated in the penis by androgens [27, 28], and when animals are castrated, a decline in both penile nitric oxide and PDE5 levels are seen [2830]. These early studies support the possibility that men with low testosterone may have a relative deficiency of PDE5, resulting in lower efficacy of PDE5 inhibitors [31]. In a randomized controlled trial by Shabsigh et al., dual treatment with sildenafil and testosterone was more effective than monotherapy with sildenafil for men with testosterone levels <400 ng/dL who had previously failed a trial of PDE5 inhibitors. Men receiving both testosterone and PDE5 inhibitors had an improvement of 4.4 IIEF points from baseline to 4 weeks while those receiving monotherapy only saw an increase of 2.1 IIEF-EF points (p=0.029) [32].

While Buvat et al. observed a positive effect in hypogonadal PDE5 inhibitor non-responders, other RCTs have not observed such a positive effect. In a 2012 RCT, Spitzer et al. studied 140 men on sildenafil and then randomly assigned them to either receive testosterone or placebo gel. All men had a testosterone level <330 ng/dL or a free testosterone level <50 pg/mL. At 14 weeks, those on dual therapy had an IIEF-EF score 1.01 points higher than those receiving sildenafil plus placebo gel (p=0.36). This study demonstrates that the giving testosterone to men who respond to PDE5 inhibitors may not further improve erectile function after normalization of testosterone levels. However, there is growing evidence supporting the use of testosterone in men with low testosterone and mild ED, especially in those who were previously non-responsive to PDE5 inhibitors [33, 34].

These recent studies suggest that TTh may be most effective as monotherapy in improving erectile function in men with mild ED, but not in men with more severe ED. Early studies have shown that TTh can improve the response to PDE5 inhibitors in non-responders.

Libido, or sexual drive, is affected by a multitude of factors, including physiologic ones, such as a defect in the hypothalamic-pituitary access or depression, or environmental ones, such as marital discourse or anxiety [3, 35, 36]. Changes in libido can variably affect individuals, with a wide range of clinical presentations. Longitudinal studies have found that libido declines with increasing male age [35]. When assessing libido, many studies use the sexual desire (SD) domain of the IIEF (IIEF-SD), which asks men to two libido-related questions: Over the past 4 weeks, how often have you felt sexual desire? and Over the past 4 weeks, how would you rate your level of sexual desire? Like the IIEF-EF domain, the IIEF-SD questions can be used to diagnose mild, mild to moderate, moderate, and severe dysfunction [7]. Other studies have used their own scale, such as the Sexual Arousal, Interest and Drive scale (SAID) a validated patient reported outcomes measuring 5 scored items, including sexual thought, arousal, as well as interest and drive [37].

Several early studies have demonstrated that TTh improves libido [38, 39]. Recently, the Sexual Function sub-trial of the Testosterone Trials examined sexual desire. This placebo-controlled trial included 470 men aged 65 years or older with testosterone levels less than <275 ng/dL [24]. When assessing the impact of TTh on sexual symptoms, the authors used the Derogatis Interview for Sexual Function-Sexual Desire Domain, comprised of 25 scored items, and found that libido improved proportionately with increase in testosterone levels, with an effect size of 0.44 [95% Confidence Interval: 0.32 0.56] [40]. Interestingly however, these trials found no threshold below which libido was universally affected for all men in the study.

The results of the largest placebo-controlled multicenter trial assessing the effect of testosterone on sexual function in hypogonadal men (715 men, 18 years of age and older) were published in 2016. Brock et al. found that 60 mg of topical testosterone 2% gel applied daily resulted in a significant increase in testosterone levels as well as libido, as measured using the SAID scale after three months of treatment. The study examined a cohort of hypogonadal men with a mean age of 55. Though not placebo-controlled beyond the third month, the open label continuation of the trial for both placebo and active treatment groups showed continued improvement in sexual function at 9 months when on continuous TTh, with no new adverse events [23]. In the group initially treated with placebo, 60% of men achieved normal testosterone levels at the end of the open label study, compared to 66% of the participants on TTh for the duration of the trial. Interestingly, the group that had received placebo before the 3-month time point and later placed on the open-label TTh achieved the same libido improvements as the group that had been on TTh for the entire 9 months. This finding suggests that benefits of TTh on libido plateau after 3 months of therapy. However, the study lacked a true control arm during the open-label portion of the trial, limiting the ability to make this conclusion. Furthermore, a post hoc analysis of the trials outcomes after 3 months further revealed that a lower testosterone level at the start of treatment and higher plasma concentration achieved at the end of treatment were associated with a greater patient reported improvement in libido [41].

The Corona et al. meta-analysis also assessed the impact of TTh on libido in hypogonadal men, finding that for 1,269 men across 14 randomized, placebo-controlled trials, the IIEF-SD significantly improved (p=0.001) [25]. These findings suggest that TTh may be more effective in improving sexual desire than in improving erectile function in men with moderate or severe ED. Citing previous studies that had failed to show improvements in libido on therapy, Corona et al. highlighted that many of these studies did not specifically examine a population with low testosterone at baseline and that in eugonadal men, TTh may be less beneficial in improving libido.

While TTh can improve libido, it is not without its risks [42]. Due to the wide-spread use of testosterone-related products for seemingly age-related symptoms and the potential cardiovascular risk, the FDA has commissioned a large clinical trial to assess the safety of testosterone products [43]. A joint patient-physician decision should be made whether the potential improvement in erectile function, libido, and energy with TTh outweighs the potential side-effects in each individual patient.

Many studies have demonstrated that TTh significantly improves libido in men. Moving forward, large RCTs specifically studying older men for more than a year of treatment are needed to better determine at what testosterone thresholds men demonstrate improvements or decrements in sexual function and desire. Finally, current measures of evaluating libido are either very narrow in their scope or not validated. As such, future work should focus on more clearly defining the impact of TTh on libido.

In men with low testosterone, normalizing testosterone levels has multiple benefits, most notably improved libido and improved erectile function when used as monotherapy in men with mild ED. For the latter, TTh is especially promising in hypogonadal men with mild ED who are unresponsive to phosphodiesterase-5 inhibitors. Testosterone therapy may be ineffective in men with moderate and severe ED, as the etiology for these more severe pathologies often include advanced diabetes, radical pelvic surgery, or severe neurologic damage. In these cases, a hormonal factor is often not the primary cause of dysfunction, and thus while TTh should be considered, other treatments are likely to be more effective.

Key Points

Testosterone replacement monotherapy can improve erectile function in men with mild ED, but not moderate and severe ED.

In men with low testosterone who are unresponsive to PDE5 inhibitors, normalization of testosterone levels can improve the response to PDE5 inhibitors.

Testosterone therapy improves libido in men with low testosterone.

Funding

A.W.P. is a National Institutes of Health K12 Scholar supported by a Male Reproductive Health Research Career Development Physician-Scientist Award (HD073917-01) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Program (to Dolores J. Lamb).

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Low Testosterone and What You Can Do About It – The Epoch Times

Posted: July 11, 2022 at 2:51 am

Its possible you dont have the energy, libido, or mood you used to. There can be several reasons, but one may have to do with dropping testosterone.

Testosterone is a hormone found in all humans. However, it plays a far more prominent role in men than women. It plays a role in sex drive, bone and muscle mass, fat storage, and red blood cell production. It may also affect a mans mood.

Testosterone typically peaks in a mans 20s or early 30s before it starts tapering off slowly over time. But everybodys baseline testosterone level is different. Some men are born with a lot of testosterone, while others are born with less. Normal testosterone can be anywhere from 280 to 1,100 nanograms per deciliter (ng/dL), which is a huge range.

So, somebody who has 1,100 ng/dL may feel it a lot more if levels get to 950 ng/dL than someone who starts with 500 ng/dL and sees it drop to 100 ng/dL. The difference may be more pronounced.

What might it feel like?

Low testosterone may create some of the following symptoms:

Youll only learn if you have low testosterone through blood tests, and youll only understand the rate its dropping with several tests used to track changes over time.

What can you do about it? There are a few things that may halt testosterone loss or at least slow it.

Diet and exercise can both play a role in testosterone levels. Weight training is associated with higher testosterone, and so is eating a nutrient-rich diet that is low in processed food. Fruits, vegetables, nuts, lean proteins, legumes, etc., is the way to go.

Managing weight may also help.

Testosterone replacement therapy, or TRT, is a procedure that can help, as well. It is still under study, but talk to your doctor if you believe low testosterone affects your quality of life.

Mat Lecompte is a health and wellness reporter for Bel Marra Health, which firstpublishedthis article.

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Men Share The Costly Lengths They’ve Taken To Prevent Balding – HuffPost

Posted: July 11, 2022 at 2:47 am

As he was approaching 25 about a decade ago, David DiMuzio looked in the mirror and generally liked what he saw. But then there was his hairline: thinning and creeping backward, it looked like it belonged to a completely different guy one that was at least a few decades older than DiMuzio.

My hair felt like it was the only thing in my life that was working against me, said DiMuzio, a 36-year-old singer songwriter. Id look in the mirror and my hairline didnt feel like it should be my hairline. This should be the hairline of a guy whos like 60 years old.

DiMuzio was hitting his stride as a musician in the Philippines; his songs often ranked high on MTV music video countdowns in the country. Still, looking in the mirror, he couldnt shake the feeling that his hairline was holding him back professionally and personally.

With some research and consultations, DiMuzio found out he was a Norwood 5 on the Hamilton-Norwood scale, a classification system that uses a 1 to 7 scale to gauge hair loss.

A Norwood 5, he learned, is considered an advanced stage of baldness in men.

Demoralized by that number, he sought out a hair transplant. In search of more fullness, he decided to get another transplant, this time with a different surgeon. (Its not uncommon for hair transplant patients to undergo multiple surgeries.)

The second was problematic. The surgeon lost his license in Tennessee not long after performing DiMuzios surgery, and he went overboard with the musicians hairline.

He went well outside what is considered the safe zone in taking tissue from the back of my head and transplanting it to the front, DiMuzio told HuffPost. Because of that, I have a larger scar than I should, and it was not as successful of surgery as it should have been.

Since then, DiMuzio has gone on to correct the shoddy work. A few weeks ago, he had his fifth transplant. He also takes Finasteride (the generic name for Propecia) and minoxidil (the generic name for Rogaine) and uses an iRestore laser cap for hair growth. Hes happy with this hair today.

Even the scar is covered up by hair, and the hair looks great now, he said.

Of course, it came at a steep cost. The singer has spent $35,000 of his own money; two of his five surgeries were offered to him free by doctors hoping to make an appearance on his popular YouTube channel Hair Loss Hope, where he doles out advice to the young and follicly challenged.

There are more young guys concerned with their hairline than youd expect. Like many other procedures including nose jobs and Brazilian butt lifts, there was an uptick in patients requesting hair transplants during COVID. The lockdown meant you didnt have to worry about a coworker or friend seeing your bandaged-up head.

Dr. Marc Dauer, a hair restoration surgeon who practices in Los Angeles and New York City, told the New York Times that at the peak of the pandemic, his offices saw a 30% surge in hair transplant procedures and a 50% increase in transplant consultations.

But even before the pandemic, the demand for hair transplants was high. The hair restoration industry is projected to reach over $12 billion in 2026. The increase in stress-induced hair loss that came with the pandemic will probably only add to those numbers.

The patients coming in are getting younger and younger, too. These are guys concerned about looking Instagram perfect and not wanting to have to hatfish on Bumble or Tinder. (A clever play on catfishing, a guy who hatfishes looks great on screen, but strangely, hes wearing a hat in all of his photos.)

A bald person will listen to anyone who gives tips about hair growth.

- Amir ur Rehman, a 29-year-old engineer from Dubai who has had three hair transplants

On Facebook groups about hair loss and Reddit forums like r/tressless, young people commiserate over premature hair loss (aka the Norwood Reaper) and relay their experiences with different hair-restoration clinics around the world. (When it comes to hair tourism, Turkey is a hot spot.) They debate what procedures they suspect celebrities like Matthew McConaughey, LeBron James and Chris Evans have undergone through the years and analyze each others post-op pictures.

These robust online conversations have led people as young as 17 into plastic surgeon Monica Kieus office, looking for a consultation. Its worth noting here: Male pattern baldness can start showing as early as your late teens, but typically, hair specialists dont recommend a hair transplant for people under the age of 25 since your hairline likely hasnt settled yet and you dont quite know what youre working with.

As many aesthetic procedures are becoming more common and accepted, I have noticed younger patients seeking out hair restoration therapy, Kieu, whose office is in Newport Beach, California, told HuffPost. Although women are also seeking out hair transplants, the majority of my patients are still men between the ages of 20-60.

Jan Oliva, a 22-year-old from Southwest Florida, got his hair transplant under the cover of lockdown last year. Oliva went to the Dominican Republic another hair transplant hotspot for his work.

I first started noticing my receding hairline when I was around 16 and ever since then it was definitely a factor that affected my self esteem, he told HuffPost. It wasnt until last year that I decided to do some research on hair loss treatments.

Oliva had FUE follicular unit extraction. Its a procedure where the hair follicles are transplanted from the back of your head to your hairline without leaving any noticeable scarring. Over the years, FUE has become more popular than the follicular unit transplantation (FUT) the older procedure where the surgeon and technicians take a strip of skin from the back or the side of the scalp and then extract the hair follicles.

In the U.S., the FUE hair transplant could run you anywhere from $4,000 and $15,000 per session. Oliva said his surgery in the Dominican Republic came out to $2,800.

He found out about the surgeon on TikTok, another place where young men and some women regale others with their experiences with hair transplants, replete with images of the slightly unnerving looking immediate aftermath. (Almost every patient deals with some facial swelling and swelling of the scalp after a hair transplant.)

Now he makes hair restoration TikToks himself.

Im very happy with the results, he said. I might actually have to do it again because I only did my hairline.

Amir ur Rehman, a 29-year-old engineer from Dubai, also got his hair transplant when he was on the younger side.

At 23 years old, he felt way too young to be bald and he was sick of his phone resurfacing photos of him on this day in 2013 when he still had a healthy, enviable crop of hair.

His wife was fine with him balding in his early 20s, but it didnt sit right with him. Some people suggested I should wear a wig, but youll never get satisfaction wearing a wig, he said.

He tried shampoo after shampoo and took advice from anyone whod offer some, but nothing seemed to work.

I got scammed in Dubai by some random guy who offered me some herbal medicine the hair scam is very famous in Dubai, he said. A bald person will listen to anyone who gives tips about hair growth.

Eventually, fearing the dreaded comb-over, he caved and got his first hair transplant in 2019 in Pakistan, where you can get the procedure for a fraction of what it costs in the West.

The results werent great, though, and the engineer ended up pursuing two more surgeries.

Now, no one would suspect he was an almost-balding guy once. Hes happy with his hair but wants people considering hair transplants to temper their expectations. Transplanted hair look will never be the same as your natural hair, he said, no matter where you do the transplant and how many you do.

With a hair transplant, you will think about the back side the donor area and the empty spaces there, he said. If you cut too much, it will be visible. You have to adopt a hairstyle that caters to where the density looks good.

Courtesy of Amir ur Rehman

Hair transplants arent the only option to explore

For most young men, the first action they take is typically topical treatments like minoxidil (Rogaine) and oral medications like finasteride (Propecia), which you take once a day.

These therapies can be effective in preserving hair and preventing further loss, but the only treatment to actually regrow hair where it is already balding is a hair transplant, Kieu said, pointing out to some new advancements in hair transplantation technology, like robotic hair restoration, where surgeons use AI to assist in the procedure.

This increases our efficiency while also minimizing scarring that we see in older techniques, she said.

For non-surgical hair restoration, Kieu said exosomes hair therapy has been an exciting newer development.

Exosomes are derived from stem cells, and they help with cell-to-cell signaling, which has powerful effects on cell function, she said. They contain growth factors, which stimulate your hair follicles to grow. Its a relatively quick procedure that we can do in-office in about 30 minutes with minimal downtime.

Hair restoration and preservation is definitely an investment in time and money. This is not the time to bargain shop.

- Monica Kieu, a plastic surgeon and hair restoration specialist in Newport Beach, California

Those procedures didnt exist when Spencer Stevenson, 47, got his first hair transplant about 20 years ago.

At the time, there was a dearth of information about hair transplants on the web. In fact, he found out about the clinic he ended up going to through a Super Bowl ad.

Before that, I looked in the Yellow Pages. I tried every single treatment that was available powders, paints, pills, lotions, all sorts of stuff which none of them worked, sadly, the Brit told HuffPost.

That led me to get an unfavorable hair transplant in the U.S., he said. I flew over from the U.K. to the U.S. and that resulted in really, really poor unnatural work.

Stevenson who goes by Spex Hair online and is something of a hair loss godfather, with quotes on BBC News, The Guardian and a radio advice show was left with scarring and dull hair on the top of his head.

After that first surgery, Stevenson had a few more unsuccessful surgeries. He lived under his hat; when hed take it off, his friends would make jabs about how the formerly follicularly blessed Stevenson was now prematurely balding.

Badgering is bad enough, but what makes it worse is that men are considered vain if they pursue cosmetic surgeries. People assume hair loss is just something you have to accept as part of the aging process. But as countless men and women on online forums like r/tressless will assure you, its not easy to watch globs of your hair collect in your shower drain when youre only 25.

The loss of my hair had a profound effect on me, on my self-esteem, Stevenson said. Hair loss is a cancer of the spirit, it traumatizes individuals and it really is a hidden epidemic.

Courtesy of Spencer Stevenson

Today, Stevenson has spent in the region of 40,000 pounds, which is close to 60,000 U.S. dollars, to try and restore and maintain his hair.

I would do it all over again. Its completely transformed my life now, he said. My motivation was purely to try and live a normal life and not an isolated one. I was consumed by my hair. It was the first thing I thought of when I woke up and the last thing I thought of when I went to bed.

Stevenson was so mentally scarred by his earlier work, he now co-hosts a radio show, The Bald Truth, to help people know what to look for in a hair specialist.

Im an advocate in this space because I want to protect consumers from making the same mistakes I made at first, he said. This industry is a ruthless space governed by money and taking advantage of the hapless hair loss sufferer.

Courtesy of Spencer Stevenson

How to do your research and avoid a long, drawn-out loss journey

So how do you have as seamless of a hair transplant surgery as possible?

When researching a hair transplant clinic, Kieu advises to look long and hard at before-and-after photos, and always check online reviews.

A board-certified physician should always be performing the procedure, and if possible, go to the clinic in-person for your consultation, so you can feel out the vibe, she said.

Turkey is probably the most common location outside the U.S. where patients go to have their hair transplants, but Kieu would caution people that prior research is important if they are going out of the country for a procedure.

I have heard of many horror stories of botched jobs, with no ability for any follow-up or recourse since the clinics are so far away and difficult to contact, she said, noting that as a specialist in hair restoration, about 20% of her practice is covering up scars from previous hair transplants or making obvious transplants look more natural.

Stevenson recommended looking for a reputable surgeon by looking through the International Alliance of Hair Restoration Surgeons.

Doctors on there have been screened, have been monitored and have an ethical moral duty to make sure people get the right work for them or even turn people away if not an eligible candidate, he said.

There are far more options in the hair restoration world than there were 20 years ago, when Stevenson was at his most desperate. Dont jump at the first option or try to financially cut corners with your head of hair.

As Kieu said and what all these guys stories attest to hair restoration and preservation is definitely an investment in time and money. This is not the time to bargain shop.

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Magnetic bandages with stem cells to be used to repair worn joints and mend broken bones… – The Sun

Posted: July 11, 2022 at 2:45 am

MAGNETIC bandages may soon be used to repair worn joints and mend broken bones.

Combining the dressings with an injection of stem cells helps cartilage and bone to regrow, researchers found.

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The method, in which patients would recover at home, could spell the end of hip and knee replacement ops.

The NHS does about 100,000 of each every year, as well as spending 2billion on treating 850,000 broken bones.

The technique sees tiny magnetic particles attached to stem cells which are able to turn into bone and cartilage.

They are injected before being guided to the damaged areas and activated by the magnetic bandage.

In tests on sheep, the treatment sped up bone repair. Human trials are planned.

Prof Alicia El Haj, of Birmingham University, said the method worked better than existing treatments and would be quicker, cheaper and much less painful.

She said: You could have it in a GP clinic.

The breakthrough is being presented at the Royal Society summer science exhibition.

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