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Stem Cell Transplant Reverses Sickle Cell Disease in Adults

Posted: July 3, 2022 at 2:34 am

At a Glance

Sickle cell disease is an inherited blood disorder that affects more than 90,000 Americans, mostly of African descent. The condition arises from a genetic defect that alters the structure of hemoglobin, the oxygen-carrying protein found in red blood cells. The modified hemoglobin causes normally round red blood cells to become stiff, sticky, and sickle-shaped. The deformed cells can block blood flow, causing severe pain, organ damage, and stroke.

There is no widely available cure for sickle cell disease. Some children with the disease have been successfully treated with blood stem cell, or bone marrow, transplants. This approach, though, was thought to be too toxic for use in adults. High doses of chemotherapy are used to destroy all of a childs bone marrow, which is then replaced with marrow from a donor. Stem cell recipients typically need to take immunosuppressants for months to a few years. These medications can cause serious side effects.

In earlier studies, transplant recipients were found to have a mix of their own and the donors cells in their blood. Despite the mix, sickle cell disease was reversed. Based in part on these findings in children, as well as other preliminary work, a team at NIHs Clinical Center in Bethesda, Maryland, set out to test a modified transplant procedure in adults with sickle cell disease. The clinical trial was conducted by researchers from NIHs National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Heart, Lung, and Blood Institute (NHLBI). Results appeared online on July 1, 2014, in the Journal of the American Medical Association.

Thirty patients, ages 16 to 65, with severe sickle cell disease enrolled in the study between 2004 and 2013. The patients first underwent a less toxic regimen to kill off some of their marrow cells. They then underwent a stem cell transplant, receiving cells donated by a healthy brother or sister.

The team found that the stem cell transplant reversed the disease in 26 of 30 patients (87%). The patients had normal hemoglobin, fewer hospitalizations, and lower use of narcotics to treat pain from the disease. The patients didnt experience graft-versus-host diseasein which donor cells attack the recipientafter a median follow up of 3.4 years. Fifteen patients successfully stopped immunosuppression medications a year after the transplant. The treatment was unsuccessful in 4 patients, and some complications, such as infections, occurred.

Side effects caused by immunosuppressants can endanger patients already weakened by years of organ damage from sickle cell disease, says senior author Dr. John Tisdale. Not having to permanently rely on this medication, along with use of the relatively less-toxic partial stem cell transplant, means that even older patients and those with severe sickle cell disease may be able to reverse their condition.

The researchers continue to follow the patients to track the success of the approach. People with sickle cell disease interested in joining NIH blood stem-cell transplant studies may call 1-800-411-1222 or visit the NIH clinical trials registry at https://clinicaltrials.gov for more information.

Funding:NIHs National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Heart, Lung, and Blood Institute (NHLBI).

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Tisch Multiple Sclerosis Research Center of New York Study Featured in BioSpace – Business Wire

Posted: July 3, 2022 at 2:33 am

NEW YORK--(BUSINESS WIRE)--The Tisch Multiple Sclerosis Research Center of New York, the worlds largest independent research center focusing on MS, is proud to announce that its FDA-approved stem cell treatment study was featured in an article in BioSpace.

Preliminary analysis of the study results found that stem cell treatments substantially improved muscle strength and disability scores, particularly among patients with lower levels of disability. Interviewing Dr. Saud A. Sadiq, the Director and Chief Research Scientist of the Tisch MSRCNY, as well as Senior Research Scientist Dr. Violaine Harris, the article features the progress and key results of the stem cell treatment study, as well as the broader history and goals of the center.

We are excited to share more about our stem cell treatment research, which is a key study in service of our centers overarching goal of finding the cause of and the cure for MS, said Dr. Sadiq. Furthermore, the study has enormous potential not only for the treatment of MS patients, but also promising potential implications for those with other neurodegenerative diseases. Were delighted to share our analysis with the broader public and scientific community, and look forward to sharing further updates on this groundbreaking research as it progresses.

The full BioSpace article can be accessed here.

About the Tisch MS Research Center of New York

The mission of the Tisch Multiple Sclerosis Research Center of New York is to conduct groundbreaking medical research to ensure unparalleled care and positive outcomes for MS patients. Its integrated relationship with the International Multiple Sclerosis Management Practice (IMSMP) accelerates the pace at which research discoveries translate from lab bench to bedside. The Center aims to identify the cause of MS, understand disease mechanisms, optimize therapies, and repair the damage caused by MS while offering patients access to the best and most advanced treatments possible.

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Amendment added to PA budget bill would make Pitt, other universities stop fetal tissue research – WPXI Pittsburgh

Posted: July 3, 2022 at 2:33 am

Amendment added to Pennsylvania budget bill would make Pitt, other universities stop fetal tissue research

An amendment just added to the state budget bill would make the University of Pittsburgh promise that they would stop fetal tissue research.

Some politicians and doctors are differing on the topic.

On the heels of Roe v. Wade being overturned, State Representative Jerry Knowles is calling for several universities to stop doing fetal cell research.

Pitt is one of those universities, plus Temple, Lincoln and Penn State.

Pitt is expected to receive $155 million in the next year from grant money, and is known for their fetal cell research and work.

Rep. Knowles told Channel 11, I respect doctors. I dont claim to be a doctor, or a scientist. I dont think you need to be a doctor or a scientist to determine what is unethical, what is evil, and what is barbaric.

Its something local infectious disease physician Dr. Amesh Adalja disagrees with.

We have already seen benefits from stem cell research, and research that derives from fetus cells. Even some of the covid vaccines were developed. This is a life saving technology.

Pitt spokesperson Chuck Finder sent us a statement:

The University of Pittsburgh devotes every dollar of the general support appropriation it receives from the state to help support a tuition discount for Pennsylvania students and families. Were optimistic the legislature will preserve this investment in our students.

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Free Fecal Water Syndrome in Horses and What To Do About It The Horse – TheHorse.com

Posted: July 3, 2022 at 2:33 am

Unlike diarrhea in horses, free fecal water (FFW) syndrome is not life-threatening and involves free water being passed before, after, or with normal fecal balls. But because horses bodies need to conserve water, losing excess fluid in their manureeven if it is apparently benignindicates a gastrointestinal (GI) disturbance is making it difficult for the horse to manage or resorb water.

Horses move monumental volumes of water through their gastrointestinal tracts on a daily basis, said Burt Staniar, PhD, associate professor of equine science in Pennsylvania State College of Agricultural Sciences Department of Animal Science, during his virtual presentation at the 2022 EquiSUMMIT.

In terms of intake, horses need approximately 30 liters (1 liter is a bit more than 1/4 gallon) of water a day. A surprising amount of this can come from forage. Staniar said an average 500-kilogram (1,100-pound) horse consuming fresh forage from pasture containing 80% water might take in more than 22 liters of water daily.

This is simply from the forage. Even hay has 10-15% water, said Staniar.

An average horses GI tract contains an estimated 73 liters of water at any given point, which moves continuously between the circulatory and GI systems. For example, the horse secretes about 40 liters of water in saliva per day, and bile and pancreatic secretions add an additional 55 liters of water per day to the small intestine. In the hindgut (the cecum and large colon, or large intestine), however, water is resorbed, not secreted: 15 liters by the cecum and large colon each and an additional 6 liters by the small colon.

Overall, about 100 liters or 25 gallons of water are secreted into and absorbed from the gastrointestinal tract by a horse at rest, said Staniar. Water movements and conservation during exercise become even more critical due to waters essential roles in maintaining health and athletic performance.

He added, A healthy GI tract is integral for supporting these water movements. It is absolutely critical to have intact tight junctions, which are the protein links that hold the colonic cells together lining the walls of the hindgut.

When those tight junctions break down or do not function correctly, which can happen in response to any type of stress, changes in gut permeability could ensue, which negatively affect the horses ability to absorb water.

While risk factors and causes of FFW syndrome are unclear, stress could be involved. Staniar said study results suggest affected horses are lower in the herds social hierarchy, which could be a source of stress that ultimately alters tight-junction function.

Without knowing the exact cause but appreciating that abnormal water resorption is an underlying contributing factor, Staniar recommended evaluating the type of fiber being offered to horses and other nutrients that might enhance GI function.

Fiber is found in fresh and dry forages, including pelleted feeds.

Recognizing that different types of forage have unique chemical and physical properties, we can use a variety of forages to maximize GI health, he advised.

Consider, for example, the different properties of the various forages: long-stem grass hay, alfalfa, beet pulp, whole oats, soybean hulls, and wheat middlings. These, said Staniar, contain different amounts and types of fiber and moisture and can be used in various combinations to enhance gastric function.

For example, the fiber in beet pulp might be more digestible than the fiber in long-stem grass hay, but the fiber in the hay might cause the horse to chew more than the fiber in the beet pulp, the latter example leading to greater saliva production, Staniar noted. Owners need to be open to trying different types and combinations of fiber.

In addition, he explained that dietary fiber facilitates microbial fermentation in the hindgut, with the byproducts providing energy to the horse and supporting the integrity of the intestinal wall.

This concept supports the idea that pre- and probiotics, as well as butyric acid (which feed those hindgut microorganisms), will help maintain tight junctions and can be used in a multiprong approach to managing FFW, said Staniar.

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PAWcast: Valedictorian Natalia Orlovsky ’22 on Research, Mental Health, and Pandemic Princeton – Princeton Alumni Weekly

Posted: July 3, 2022 at 2:33 am

There is no wrong way to do Princeton

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Just a few days before graduating as valedictorian of Princetons Class of 2022, Natalia Orlovsky spoke with PAW about her love for both the sciences and humanities and her hopes for going into academia. As a student she worked in a bioengineering lab, served on the peer review board of thePrinceton Undergraduate Research Journal, was an undergraduate course assistant, served on the board of Theatre Intime, and has been involved with the Gender and Sexuality Resource Center. Her advice to future students is to shrug off the feeling that theres a prescribed arc to their experience, so they can feel like theyre doing Princeton correctly, regardless of how theyre doing Princeton.

TRANSCRIPT:

Carlett Spike:From an early age, Natalia Orlovsky has had a love for both the sciences and humanities. In 2018, while a senior in high school, she was featured in aWashington Postarticle about these two varying interests as she was debating whether to attend Princeton to study science or Oxford to study history. While today Natalia is just a few days shy of graduating from Princeton as the valedictorian for the Class of 2022, she ultimately picked the University because it offered a bit of both. She could study science and explore the humanities through her extracurriculars.

Natalia is a molecular biology concentrator from Chadds Ford, Pennsylvania, and pursuing a certificate in quantitative and computational biology. She has earned 10 A-plus grades in six different departments while at Princeton. Heres a few of things shes done on campus: Natalia has worked in the bioengineering lab of Cliff Brangwynne, served on the peer review board of thePrinceton Undergraduate Research Journal, was an undergraduate course assistant for both Organic Chemistry and Introduction to Data Science, served on the board of Theatre Intime, and has been involved with the Gender and Sexuality Resource Center. Her thesis work studies how two different proteins help determine the physical properties, or squishiness, of the cell nucleus, which in turn influences how easily cells can crawl through narrow passageways.

Im Carlett Spike, PAWs associate editor, and Im here today with Natalia to reflect on her Princeton journey, the lessons shes learned, and her plans for the future.

Welcome, Natalia, and thank you for coming on the PAWcast.

Natalia Orlovsky:Thank you for having me.

CS:Its a pleasure. Congratulations again on this huge accomplishment.

NO:Thank you.

CS:Can you tell us how you first found out and your reaction to the news?

NO:Oh man. So, I got an email from Jill Dolan, cryptically informing me that I should get on a Zoom call with her, and I think I, initially in response was like, Oh man, youre kidding! And she was like, No, Im not. (laughter) And I was like, OK, I see! But, I dont know; its been really overwhelming, and I feel super lucky.

CS:When she reached out, did you know the news was coming, or...

NO:Yeah, so I had a bit of forewarning. (laughs)

CS:OK, nice. So we know why you chose Princeton, for the bit of both worlds, but can you reflect on your journey up until this point and how you were able to take classes in both the sciences and humanities?

NO:Yeah, for sure. I think the main thing that drew me to Princeton was that I could do original research as an undergraduate in particular in the sciences, and so I think Ive spent a lot of time doing my independent work and doing research. Before, I started doing my formal independent work and thats been my primary mode of engagement with science, and then for a lot of my elective coursework, Ive leaned more towards English and theater, and then also Ive been really involved in the student theater community on campus, which have been my main routes of entry to the arts sphere.

CS:Can you talk a little bit more about being involved in the arts while focusing on science and finding time for both, and how you find the balance with it all?

NO:Yeah, for sure. Its interesting because I think there is this sense that most art students focus on the arts in their academic coursework as well, so I guess it is somewhat less common to have STEM folks in performing arts, but there are a lot of people who are. And its actually quite cool because its such a different mode of exploration, so its like in the lab youre doing one type of hands-on work and then in the classroom youre doing potentially computational work or youre doing more formal studying, test-taking, etc., and then in a theater context youre on your feet and youre thinking on a completely different axis, and so its kind of nice because then your hobby is legitimately relaxing, (laughs) so its I think it provides a kind of built-in break, so it becomes quite manageable.

CS:Nice. So youve taken a ton of classes at this point. What have been some of your favorites?

NO:Oh, man. So I took a few classes with Professor Bob Sandberg in the English department, which were really, really great. I think they changed how I think about theater a lot and how I think about how storytelling works and what it does for people. I think I I also took a philosophy class called Death,(laughs) which was really interesting. I was taking that during the start of the pandemic, which made for a bizarre relevance (laughs) that I didnt anticipate beforehand, but it, I think, shaped some of my more existential positions at this point.

And then, I think, the other one that I would say is Ive taken a couple of quantitative biology classes that have been super important to me, so one of them is Professor Corina Tarnitas class in the EEB department, and then another one is Ned Wingreens graduate seminar in quantitative biology, and I think I mean, I like math, and Ive liked math for a long time, but I think I didnt really see the overlap between that interest and my very experimental approach to life sciences that I generally take, and so its been really cool to learn about how to apply quantitative tools to answer questions that you cant really answer by experimental means, like questions about how things evolved, for instance, which theres not really a different angle that you can take, and its really cool to see that even with my, I think, comparatively more limited math background, there are lots of cool quantitative avenues towards science that I can take.

CS:Nice. So, you mentioned the pandemic. I was going to ask you about that. Obviously, its been a major part of your college journey. Can you talk about how the pandemic has impacted you personally, and if theres ways that its shifted your perspective and outlook on maybe both what it means to be a student and your career moving forward?

NO:Yeah. I mean, I think a couple of things, but then the first thing is that I think every Princeton student had a different pandemic Princeton experience, and I was really lucky in that I went home to a safe learning environment. And I know that wasnt true for a lot of students, so I think thats worth acknowledging. So I think personally, it was obviously very disappointing to not be able to interact with people and to not be able to do hands-on research for a long time and especially to not be able to do in-person theater performances because Zoom theater really doesnt cut it for me. (laughs)

But I think, all in all, I was really lucky. But I think, more broadly, its I think people have been talking a lot more about what kind of public relationships to science are, so Ive been thinking more about issues of science communication and how I want that to be a part of my future career in science education because I think its increasingly apparent that there is a need to speak responsibly about science and to educate people about science so that the world as a whole can respond to global challenges in an appropriate way.

CS:Following that line of thinking, ultimately, what would you say would be your dream job then?

NO:Oh, man. I think so, tentatively speaking, I think I would like to go into academia because I like both research and teaching a lot, and I want both of those things to be part of my life in some capacity, and even if I dont go into academia, I think informally, at least, I want both mentorship and research to be part of my future career. But thats all Ive got worked out at this stage.

CS:Its totally fine. Theres still tons of time to decide and figure out what you want to do. Switching gears a little bit to the upcoming Commencement, have you given your thought some your speech some thought? Have you written it? Its OK if you havent.

NO:Yeah. Im taking the time-honored Princeton approach of writing it at the last minute, I think.

CS:Are there any themes or messages that youve you really hope to impart on your classmates and how you want to leave them with?

NO:This is very tentative. It might not make it in, but I think some of what Im thinking about right now is that, I think, its an interesting moment to be thinking about transition and to be celebrating transition because I think theres a lot of things that are happening in the world that are really terrible for a lot of people, and things for a long time have been unpleasant for pandemic reasons and social inequality reasons and global turmoil reasons, and so I think that kind of changes the valence of what I think a graduation experience feels like in the moment. And so, I want to be cognizant of that, and I want to acknowledge that, but I dont quite know how yet.

And I think the other thing is that, I think if I could impart anything, I think it would be some kind of wish that people take care of themselves and each other, and I havent thought of a great articulation for that yet, but thats where Im thinking.

CS:Those are good messages.

NO:Thank you.

CS:I wanted to also ask you about your thesis. Can you talk about where the idea came from, and what its been like working on it for a while now?

NO:Yeah, for sure. In my thesis, Im looking at how these two proteins contribute to how squishy the nucleus is, the idea being that the squishier the cell nucleus, the better the cell is at climbing through little spaces and maybe at metastasizing, if its in a cancer context. And, so Cliffs lab generally works on these physical approaches to biology, and so this is, I think, not one of the main focuses of the lab at this point, but that kind of mechanical thinking is very much a part of how he approaches biology, and so I think thats where a lot of it comes from. And for me personally, I think theres just a lot of appeal in being able to take a tiny, microscopic thing and then poke it and see how it changes shape. And Im a massive microscopy nerd, so its been a lot of fun to both learn the relevant techniques to actually do the experiments and to conceptualize the project as a whole.

CS:Nice. So reflecting on the entirety of your journey as a Princeton student, what has been some of the most challenging parts?

NO:For me definitely managing mental health has been a challenge. I think even more so because of the pandemic because youre automatically also isolated from other students and from University resources. So I think a lot of it for me has been learning to manage anxiety and patterns of thinking under intense stress, because I think the Princeton semester is really fast, often painfully so.

And then I think also learning to juggle academic rigor and social health. I think especially during my first two years at Princeton, I was very much locked in a library until two in the morning, that kind of thing, and then I think the pandemic shifted a lot for me in terms of what I prioritize because I think now I spend more time with friends and I try to seek out the people I care about and make sure that theyre doing OK and in the process make sure that Im doing OK, which sometimes it feels like thats not what Princeton is built for. It feels a little bit like the expectation is that school is the first thing that you do and maybe also the last thing that you do, and if youre able to squeeze in a little bit of socializing, then good on you, but I think Ive struggled with that a bit, but Ive come to a better balance now.

CS:Thats good. You mentioned social life. What do you do outside of academics, and what do you do for fun?

NO:I play a lot of board games lately. Thats been whats been happening.

CS:Are you on the Wordle trend?

NO:I am. My friends and I all do it together, which I think is an exceptionally nerdy thing. My partners really into board games, so is our broader friend group, so thats become my go-to social activity.

CS:Favorite board game?

NO:Race for the Galaxy. Its a sci-fi themed card game, essentially.

CS:Awesome. So, you reflected on your own journey, but Im curious what advice you would offer to the incoming class if you could talk to them and just share some tidbits and tips from your journey.

NO:Sure. I think my main thought is that there is no wrong way to do Princeton. I think you come in with the sense that theres this particular arc that is prescribed and that it culminates in thesis work, and thesis work must be massively rewarding in order for you have done Princeton correctly, and the priority has to be this but then you also have to be in 70 million extracurriculars, and I think that thats ridiculous and most people dont actually live like that. I think I dont know anyone who actually lives like that. But coming to that conclusion is hard and is a process, and I think everyone goes through that process. And so I just I hope that incoming students can increasingly feel like theyre doing Princeton correctly, regardless of how theyre doing Princeton.

And also I think I would tell people that this place is hard, and it is OK to be finding it hard, and it is OK to be finding it hard in terms of academics and in terms of social things and in terms of extracurricular things because I think everyone struggles with different stuff.

CS:Absolutely. Great advice. You talked about your dream job. We wont hold it in stone. Its OK if you change your mind, but can you talk about what we can expect to see from you next; what are your plans after Princeton, after graduation; and if you have any other goals youd like to share?

NO:Yeah, sure. So, Im starting a Ph.D. program in the fall, because clearly I didnt get enough of school yet, but yes, Im starting a biological and biomedical sciences program at Harvard, and Im really excited to get to do research full time. I think Ive been pretending to be a grad student for a while, and Ive generally really enjoyed that mode of existence, so I think Im excited to keep doing basic biology research and then really excited to keep growing as an educator in particular, so, those are after taking the summer off because I think a break would be nice.

CS:Are you planning to do anything fun with your break?

NO:Yeah, Im planning to do nothing for much of it, which I think

CS:That sounds lovely.

NO: is a top priority right now, but spending time with family mainly.

CS:Absolutely. Great. Well, Natalia, its been wonderful speaking with you and getting to know you. Thanks again for coming on the PAWcast and best of luck.

NO:Yeah, thank you so much.

PAWcast is a monthly interview podcast produced by the Princeton Alumni Weekly. If you enjoyed this episode, please subscribe. You can find us on Apple Podcasts, Google Podcasts, Spotify, and SoundCloud. You can read transcripts of every episode on our website,paw.princeton.edu. Music for this podcast is licensed from Universal Production Music.

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PAWcast: Valedictorian Natalia Orlovsky '22 on Research, Mental Health, and Pandemic Princeton - Princeton Alumni Weekly

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‘World’s Greatest Tuba-Playing Car Salesman’ Bounces Back after Leukemia, Thanks to Wilmot Team – URMC

Posted: July 3, 2022 at 2:32 am

Returning home after a Fathers Day trip to New York City with his daughter in 2016, Scott Kesel thought he had come down with the flu. Bloodwork showed his blood platelets were lower than normal. He followed up with his regular physician and was given the news: he had chronic myelomonocytic leukemia (CMML).

CMML is a rare type of blood cancer that starts in the bone marrow, where blood cells are made. It can involve other areas of the body. There are only about 1,100 cases in the U.S. each year and its more common in people over age 60.

As a Canandaigua resident, Scott started his cancer journey at Wilmot Cancer Institutes Sands Cancer Center at F.F. Thompson. His oncologist laid out all the options: chemo and a stem cell transplant.

Knowing he would need a transplant, his team at Sands had him transfer to Wilmots Hematology team, where he began seeing Jason Mendler, M.D., and his transplant doctor, Omar Aljitawi, M.B.B.S.

He had chemotherapy at Wilmot, where he got to know the infusion nursing staff.

They have put a mindset in place thats so beneficial to the patient, he says.

For a stem cell transplant, his brother was the closest match they could find, although he was only a half-match. That left the option for a haplo-identical transplant available. Historically, it was required to have a closer match in order to do a transplant. With a haploidentical transplant, the donor is only half-matched. Its a newer procedure that is not available at all transplant centers, but the doctors at Wilmot have been performing the surgery since 2015.

He underwent the transplant but, unfortunately, in Scotts case, it didnt work.

For a short period, Scott went to another institution for a clinical trial. Unfortunately, that didnt work either. He developed pancreatitis and had to drop out of the trial. He also experienced cold agglutinin disease, which caused his immune system to attack his red blood cells. Cold temperatures can trigger it and he had to stay at Wilmot for about a month in a temperature-controlled room, set at 80 degrees at all times, to overcome it.

Once that resolved, the team at Wilmot suggested another treatment option to try on Scotts leukemia: a transplant with stem cells from an umbilical cord donation. Umbilical cord blood stem cells came from Australia and Spain to try to save Scotts life. He had only two cord blood units available and he needed both to have a successful transplant, which was his only viable chance to potentially cure his leukemia. Along with the cord blood, he also had radiation therapy with Louis Constine, M.D.

He had nothing but good things to say about the team that took care of him while he was hospitalized on Wilmot Cancer Centers sixth floor, the Blood and Marrow Transplant Unit.

It was exceptional. They were so friendly and accommodating right from the very beginning, he says. It wasnt limited to nurses. Theres medical technicians on the floor that were so friendly and became very good friends.

Scott Kesel (right) with Jason Mendler, M.D., at the 2019 Wilmot Warrior Walk

Thankfully, this time the transplant took. As of June 2022, Scott has been in remission for three-and-a-half years. He credits his team for getting him there.

Its an incredible group of people, he says.

But its not just his team hes grateful for. He appreciates that his life has returned basically back to normal, despite the tumultuous COVID pandemic that happened shortly after his transplant.

Hes gotten back to work and to hobbies he enjoys outside work.

I happen to be the worlds greatest tuba playing car salesman, he jokes.

This summer and fall, he has 28 gigs lined up, with different music groups around the region to keep him busy, and he looks forward to hunting and fishing during his free time.

For it all, he feels fortunate.

You have to be grateful for the outcome, he says. I got a lot of support remotely from people in my community who used the opportunity to promote bone marrow registration and blood drives, which was awful nice.

He adds, Im grateful that I ended up at Wilmot. I really couldnt have been in a better place.

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Hadjiargyrou Is New York Tech’s First Distinguished Professor | Box | New York Tech – New York Institute of Technology

Posted: July 3, 2022 at 2:32 am

Professor Michael Hadjiargyrou, Ph.D., chair of the Department of Biological and Chemical Sciences and director of the D.O./Ph.D. program, has been named New York Institute of Technologys first distinguished professor. This designation is found at most top research universities and recognizes outstanding faculty who have achieved the highest levels of scholarship over the course of their careers, earning national- and international-level distinctions and honors of the highest caliber.

Interim Provost Jerry Balentine, D.O., and I were 100 percent in agreement that Professor Hadjiargyrou should be the first at New York Tech to receive this designation, notes New York Tech President Hank Foley, Ph.D. We have some very impressive faculty researchers, and he is absolutely one of the best. He is instilling his passion for research in our students while conducting important work in our labs in a variety of areas.

Foley pointed to the range of Hadjiargyrous work, which includes studying polymeric electrospun nanofibers for cell/gene/drug delivery systems, gene and miRNA (microRNA) expression, stem cells, and the molecular and cellular basis for bone development and regeneration, and the exciting implications his research has for future applications, such as gene delivery and treatment of difficult fractures.

According to his Google Scholar profile, Hadjiargyrou has an h-index (a measure research impact based on the total number of his publications and citations) of 37, one of the highest of any New York Tech researcher and considered to be outstanding in the greater research community. Between 1998 and 2022, his published research has been cited 7,711 times. In addition to his scientific research, Hadjiargyrou has also published thought leadership and opinion pieces on topics ranging from scientific integrity to teaching practices.

I am humbled by being named distinguished professor, and I will continue to live up to the title, says Hadjiargyrou. I would like to deeply thank President Foley and Interim Provost Balentine, not only for bestowing this award, but more importantly, for their continual support of my research activities.

Hadjiargyrou, who joined New York Tech in 2012, has been responsible for reinvigorating the Department of Biological and Chemical Sciences, including enriching the curriculum and support for research activities; hiring talented, engaged faculty researchers; and establishing the D.O./Ph.D. program in medical and biological sciences. During his tenure, he has worked to expand the number of undergraduate research opportunities, which has become the hallmark of a New York Tech education.

The creation of a distinguished professorship at New York Tech supports our goals of becoming a [Carnegie-classified] Research 2 university within the next seven years, says Foley, pointing to the universitys other investments in research activities, including adding new instrumentation and resources, new graduate programs, and hiring new research faculty.

Every two to three years, the distinguished professorship role and criteria will be reviewed by the president and provost, and new candidates will be considered for the designation.

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Hadjiargyrou Is New York Tech's First Distinguished Professor | Box | New York Tech - New York Institute of Technology

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The global tissue engineering market is anticipated to reach US$ 13,236.87 million in 2022 and is project – Benzinga

Posted: July 3, 2022 at 2:32 am

New York, July 01, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Tissue Engineering Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Material Type and Application" - https://www.reportlinker.com/p06289941/?utm_source=GNW However, the market is likely to get impacted by the high cost of treatments related to tissue engineering during the forecast period.

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, material methods, and appropriate biochemical and physicochemical factors to regenerate, preserve, enhance, or replace various types of biological tissues. Tissue Engineering (TE) is a rapidly evolving discipline that aims to repair, replace, or regenerate tissues or organs by converting fundamental physics, chemistry, and biology knowledge into practical and effective materials or devices and clinical strategies.Tissue engineering has several primary functions in medicine and research: Assisting in tissue or organ repair, including bone repair (calcified tissue), cartilage tissue, heart tissue, pancreatic tissue, and vascular tissue.The field also researches the behavior of stem cells.

Stem cells can develop into many different cell types and help repair areas of the body.The 3D nature of tissue engineering allows the study of tumor architecture in a more detailed environment.

Tissue engineering also provides an environment to test potential new drugs for these diseases.The growth in the number of R&D activities with increasing awareness of tissue engineering in emerging markets is expected to support the global tissue engineering market growth.

Developed nations have adopted technological advances in tissue engineering and regenerative medicine that contribute to expanding the global tissue engineering market.Ever since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was declared a public health emergency of international concern in late January 2020, medical professionals and researchers have been urging the need for comprehensive and rapid testing of citizens to plan measures that can contain the spread of the virus.The COVID-19 pandemic has become the most significant challenge across the world.

This challenge was frightening, especially in developing countries worldwide, as it expected to reduce imports due to disruptions in global trade in the coming years.To date, no definitive treatment against the COVID 19 has been established.

Hence, the lack of definitive therapy offers significant opportunities for the tissue engineering market as the US FDA has recently approved the use of plasma therapy for critically ill COVID 19 patients.

Over time, real-time polymerase chain reaction tests and antibody tests have emerged as vital techniques for the global healthcare system in managing the outbreak.The supply chain disruptions and the enormous demand for effective diagnostics and therapeutics for the treatment of COVID 19 put the healthcare research industry in a critical situation in various regions.

Risks were majorly on emerging markets that face healthcare constraints and tighter financial conditions. The COVID-19 pandemic also hampered clinical trials, drug development, and the diagnostics industry's operation in the region.Also, significant disruptions to routine research activities involving tissue engineering and regenerative medicines were observed due to the pandemic.Many industries were affected by the crisis, including tissue engineering research activities, due to the shutdown of research centers, lack of healthcare facilities, and an increasing number of cases.

However, after the emergence of the COVID-19 vaccine, research centers have commenced studies and research on stem cells, regenerative medicine, and other therapies. Hence, the tissue engineering market in Europe is gaining attention after the COVID-19 impact.Based on material type, the global tissue engineering market is segmented into synthetic material, biologically derived materials, and others.In 2022, the biologically derived materials segment is anticipated to account for the highest share of the global tissue engineering market.

A biomaterial plays a significant role in the development of tissue engineering and biomedical devices that naturally increase the regenerative potential of tissues to restore body mechanisms in a state of deterioration.Biologically derived materials are used in creating neo-tissues in vitro that are identical to their fundamental body parts.These materials also help in tissue regeneration by a controlled presentation and on-demand release of specific chemokines at injury sites, tissue-resembling structural, temporary biodegradable support matrices with natural and functional characteristics.

However, the synthetic material segment is likely to register the highest CAGR in the global tissue engineering market during the forecast period.Based on application, the global tissue engineering market is segmented into orthopedic, musculoskeletal & spine, neurology, cardiology and vascular, skin & integumentary, urology, GI & gynecology, cancer, and others.The orthopedic, musculoskeletal & spine segment is expected to lead the market in 2022.

However, the skin & integumentary segment is anticipated to register the highest CAGR in the global tissue engineering market during the forecast period.The World Health Organization (WHO), the US Food and Drug Administration (FDA), Centers For Disease Control And Prevention, American Heart Association, Biomedical Advanced Research and Development Authority, and Foundation For Innovative New Diagnostics are some of the major primary and secondary sources referred for preparing this report.Read the full report: https://www.reportlinker.com/p06289941/?utm_source=GNW

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The global tissue engineering market is anticipated to reach US$ 13,236.87 million in 2022 and is project - Benzinga

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Family Health Care Atlanta | Primary & Preventative Medicine

Posted: July 3, 2022 at 2:29 am

Family Practice Center, PC, is a comprehensive medical practice where we provide healthcare the way you hoped it could be. Our attentive, patient-focused approach to medicine is the main reason we have become one of the highest-rated primary care practices in the Georgia. We pride ourselves on providing a wide variety of healthcare needs for our patients including top-level care and in-house-diagnostic testing. Led by practice Founder and CEO Dr. James Wheeler, along with a team of doctors. These physicians, as well as a full team of physician assistants, nurse practitioners, medical assistants, and other healthcare professionals, pride themselves on providing the best possible experience for each and every patient we see.

We strive to offer a wide variety of medical treatments and services, including staying up-to-date with the latest health news and trends, in order to best serve our patients and their loved ones. In addition to general family medicine, our physicians specialize in providing dermatological care, sports medicine, womens health service, and preventative medicine (including immunizations). Our selection of in-house diagnostic testing includes x-rays, bloodwork, ultrasounds, echocardiograms, and more. We are able to perform minor surgical procedures in our office at the convenience of our patients.

Our healthcare providers consider it an honor to take care of our patients and their families. Contact Family Practice Center today for more information or to schedule an appointment. Ask us about Medicare eligibility. And keep an eye out for news about our new locations in the metro Atlanta area.

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Family Health Care Atlanta | Primary & Preventative Medicine

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Preventative medicine in Rochester Hills MI

Posted: July 3, 2022 at 2:29 am

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Preventative medicine in Rochester Hills MI

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