If youve changed your supplement routine since the pandemic, youre not alone. According to a 2020 survey conducted by the Council for Responsible Nutrition (CRN), more than 43 percent of dietary supplement users have switched things up. Among those who updated their regimens, 91 percent reported increasing their supplement intake, either by adding new supplements, taking the same supplements more regularly, or upping their dose(s). Overall immune support and health and wellness benefits are cited as the top reasons.

But while supplements are often seen as a method to ensure you meet your daily nutritional needs, they can create problems if youre not careful. Like drugs, dietary supplements can affect the way your body functions, which can cause adverse effects in some people, according to an article published in the May 2022 issue of U.S. Pharmacist.

So, how do you know if youre overdoing it with the supplements? Read on to find out.

[In general], a supplement is something youre not getting enough of through food, says Rohit Moghe, PharmD, CDCES, a pharmacist with Trinity Health Mid-Atlantic in Philadelphia, and member of the American College of Lifestyle Medicine (ACLM).

To fill in these nutrient gaps, many people turn to gummies, capsules, powders, tinctures, and even saline solutions delivered via needle (known as IV therapy).

In the Dietary Supplement Health and Education Act of 1994, Congress defined supplements as products (other than tobacco) that are intended to supplement the diet, contains one or more dietary ingredients (including vitamins, minerals, herbs, botanicals, amino acids, or other substances) or their constituents, is intended to be taken by mouth as a pill, capsule, tablet, or liquid, and is labeled as a dietary supplement.

While many people are able to meet their nutrient needs through their diet, others may benefit from supplements. Particularly those who face a greater risk of nutrient deficiencies, including those with higher requirements (like children, adolescents, and pregnant and lactating women), those who struggle to absorb nutrients (like older adults, obese individuals, and people with chronic conditions), and those who follow a restrictive diet (like vegans and vegetarians), according to an article published in January 2018 article in Nutrients.

For example, a vitamin B12 supplement may be a good idea for older adults and people who follow a vegan or vegetarian diet. Vitamin B12 helps keep your blood and nerve cells healthy, and plays an important role in making DNA, per theNational Institutes of Health (NIH). Its found naturally in animal foods, which means vegans and vegetarians may not get enough through diet alone. Older adults may also be deficient in vitamin B12, because many dont have enough hydrochloric acid in their stomach to absorb it, according to the NIH. Therefore, both groups might benefit from a vitamin B12 supplement.

A common concern about supplements is that the industry, in general, is under-regulated. Unlike medications, supplements dont have to be approved by the U.S. Food and Drug Administration (FDA) before theyre sold or marketed.

New legislation, proposed by Senate Majority Whip Dick Durbin, a Democrat from Illinois, and Sen. Mike Braun, a Republican from Indiana, aims to improve the safety of dietary supplements by requiring manufacturers to list their products with the FDA under the Dietary Supplement Listing Act of 2022 a bipartisan initiative. The new legislation, which refers to the Dietary Supplement Health and Education Act of 1994, points out that in 1994 there were about 4,000 dietary supplements marketed in the United States, but the industry has boomed and now 50,000 to 80,000 products are available.

In the meantime, consumers cant be sure the supplements theyre taking are safe or effective.

Even if a supplement is considered generally safe, it may not be safe for you. Most vitamins and minerals have a risk of harm with dosages, and the risk is based on the individual nutrient and patient, says Ravi Tripathi, MD, medical director of critical care services for the Ross Heart Hospital at The Ohio State University Wexner Medical Center in Columbus. When it comes to supplements and risks, there is no one size that fits all, he says.

For example, people with an inherited condition called hemochromatosis have to be careful with iron supplements, as hemochromatosis causes toxic levels of iron to build up in their bodies, notes theNIH. And while most people dont get enough potassium even when diet and supplements are combined, according to theNIH, people with chronic kidney disease can develop abnormally high levels of potassium in their blood. This condition, known as hyperkalemia, can cause serious heart problems if left untreated, according to theNational Kidney Foundation.

Supplements can pose risks even in otherwise healthy people. According to theNIH, youre more likely to have side effects from dietary supplements if you take them at high doses or use many different supplements.

The symptoms from taking more supplementation that your body needs vary depending on the nutrient and the amount taken, and may only show up in blood tests. However, there are some physical signs to watch for. According to the May 2022U.S. Pharmacist article, general symptoms to look out for may include:

Why its good for you: Vitamin D (also known as the sunshine vitamin) helps your body absorb calcium, making it a key nutrient for bone health. Your body also needs vitamin D to carry messages between your brain and your body and fight off bacteria and viruses, according to the NIH.

Why you might be overdoing it: On the one hand, 40 percent of Americans are deficient in vitamin D, per blood tests (when serum levels are less than 50 nmol/L), according tofindings published in June 2018 in Cureus. The reason? Most of us arent getting enough sunlight exposure, notes the NIH. Taking a vitamin D supplement may help and the CRN survey shows this supplement is becoming more popular but its important to watch your dosage to ensure you dont get more than 100 micrograms (mcg) a day. According to the NIH, overdosing is almost always caused by taking supplements, as opposed to sunlight exposure or eating vitamin Drich foods.

Risks: Very high levels of vitamin D can cause nausea, vomiting, muscle weakness, pain, loss of appetite, dehydration, and kidney stones, per the NIH.

Why its good for you: Iron is a mineral your body needs to make hemoglobin, a protein in red blood cells that carries oxygen throughout your body, according to theNIH. It also helps your body make hormones.

Why you might be overdoing it: Iron supplements are often recommended for younger women to help offset iron lost during menstruation. But according to theCleveland Clinic, many women continue to take supplements containing iron after menopause, when menstruation stops and iron needs decrease.

Risks: Getting too much iron can cause gastrointestinal (GI) symptoms like constipation, nausea, vomiting, abdominal pain, and diarrhea, per the NIH. Overdosing on iron can also lead to inflammation of the stomach lining and ulcers. Although rare, extremely high doses of iron (in the hundreds or thousands of milligrams) can even cause organ failure, coma, convulsions, and death, according to the NIH.

Why its good for you: According to theNIH, vitamin A is important for vision, immune health, reproduction, growth, and development.

Why you might be overdoing it: Its pretty easy for most people to score plenty of vitamin A. If you eat cereal for breakfast and carrots or sweet potatoes at lunch, and then pop a supplement for eye health, youve probably gone over the recommended amount, says the Cleveland Clinic.

Risks: High levels of vitamin A can cause severe headaches, blurred vision, nausea, dizziness, muscle aches, and coordination issues, notes the NIH.

Why its good for you: Vitamin C, also known as ascorbic acid, acts as an antioxidant, helping to protect your body from free radical damage. According to theNIH, your body also needs vitamin C to make collagen, a protein thats important for wound healing.

Why you might be overdoing it: The CRN survey found that vitamin C supplements have seen a big boost since the pandemic. However, most people can get enough vitamin C through food. In fact, 1 cup of strawberries, chopped red pepper, or broccoli will provide the daily amount needed, per Mayo Clinic.

Risks: Taking too much vitamin C can cause diarrhea, nausea, and stomach cramps, according to Mayo Clinic. Vitamin C supplements may also interact with cancer treatments like chemotherapy and radiation therapy, per the NIH. In addition, a past study found that men who took vitamin C supplements had a higher risk for developing kidney stones.

Why its good for you: Calcium is a mineral that builds and maintains strong bones. It also plays a role in nerve function, circulation, and hormone release, according to theNIH.

Why you might be overdoing it: You may be tempted to load up on calcium supplements to protect your bones, but according to theCleveland Clinic, its surprisingly easy to overdo it. Especially if youre already getting calcium from your food.

Risks: Excess calcium has been linked to constipation, kidney stones, kidney failure, heart problems, and cognitive issues, according to the Cleveland Clinic.

Experts often recommend speaking with your doctor before trying a supplement. Unfortunately, many physicians and nurse practitioners arent as knowledgeable in this area. I find many [healthcare professionals] are grossly unprepared to answer their patients questions, and they wind up telling them that supplements are a waste of money, when maybe theres a product that may actually work for your intended use, Dr. Moghe says.

If youre interested in adding a supplement to your diet, Moghe suggests talking with a physician trained in integrative medicine or nutritional medicine, a pharmacist, naturopath, or registered dietitian. You can check the directories of the National Board of Physician Nutrition Specialists and the American Board of Physician Specialties to find a healthcare professional who works for your needs.

Simple blood tests can reveal if youre deficient in specific nutrients, but the routine blood work at your annual physical doesnt typically include these tests, although some nutritional deficiencies can produce changes on these labs, according toRush University. Youll have to request these blood tests when you visit your doctor. A physician trained in integrative medicine and/or nutritional medicine, a pharmacist, naturopath, or registered dietitian may be able to offer suggestions and a tailored approach to getting the right levels of nutrients for you, and explore whether it makes sense to test for specific vitamin deficiencies given your unique lifestyle, diet, and health.

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Can You Take Too Many Supplements? - Everyday Health

Health experts warn that diabetes has become a silent epidemic in the U.S.and a silent killer. For the last two years, deaths from diabetes have hit record levels. It doesn't have to be this way. For many people, diabetes is preventable. Diabetes can lead to serious health complications like heart disease and stroke, so it's important to take steps to avoid developing the disease if possible. That includes avoiding the #1 root of diabetes. Read on to find out moreand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Diabetes is the body's inability to process sugar (glucose). Normally, when a non-diabetic person consumes sugar, their pancreas releases an enzyme called insulin to help cells convert and use sugar for energy. In a diabetic person, the pancreas either doesn't make insulin, or the body becomes resistant to insulin. Blood sugar can builds up in blood vessels, causing damage. This can lead to an increased risk of heart disease, stroke, blindness, even amputation.

Type 1 diabetes, once known as "juvenile diabetes," can develop at any age. But type 2 diabetes is the kind that has become epidemic in the United Statesup to 95% of people with diabetes have this typeand it's directly connected to diet and lifestyle choices. Experts predict one in 10 people will have diabetes by the year 2045.

There are many risk factors for type 2 diabetes, but one of the biggest is a poor diet high in processed foods and added sugar. They're closely relatedmany processed foods quickly break down into sugar. When the body is swamped with sugar, it can become resistant to insulin. The body isn't able to process glucose for energy, and serious health consequences can follow.

Eating this kind of diet increases your risk of being overweight or obese, a major contributor to diabetes. "You are more likely to develop type 2 diabetes if you are not physically active and are overweight or obese," says the National Institutes of Health. "Extra weight sometimes causes insulin resistance and is common in people with type 2 diabetes. The location of body fat also makes a difference. Extra belly fat is linked to insulin resistance, type 2 diabetes, and heart and blood vessel disease."

It's especially important to limit or avoid sugar-sweetened beverages, such as sodas, juices and sports drinks. The average American consumes the equivalent of 17 teaspoons of sugar a day, mainly through sugar-sweetened beverages, desserts and sweet snacks.

"A lot of the foods we eat are diabetogenic. What that means is they increase your risk for insulin resistance and diabetes," says Aaron Hartman, MD, a board-certified functional medicine and integrative medicine doctor in Richmond, Virginia, and assistant clinical professor of family medicine at Virginia Commonwealth University. "Sugars are one diabetogenic food. Processed carbohydrates are another. The first rule of thumb if you want to prevent diabetes is to eat real food." A diet rich in fruits and vegetables, whole grains, lean protein (especially fatty fish, like salmon) and good fats (like avocados, nuts and olive oil) may reduce your risk of diabetes and other chronic illnesses like heart disease and cancer.6254a4d1642c605c54bf1cab17d50f1e

To reduce your diabetes risk or manage your diabetes, increasing your physical activity is important. Exercise builds muscle and makes them more sensitive to insulin, so the body utilizes it better. "For people who have diabetesor almost any other disease, for that matterthe benefits of exercise can't be overstated," says Harvard Medical School. "Exercise lowers blood glucose levels and boosts your body's sensitivity to insulin, countering insulin resistance." Studies have found that all types of exercise help, but a combination of aerobic exercise and resistance training is particularly effective in reducing insulin resistance. Experts recommend aiming for 150 minutes of moderate-intensity exercise each week, including two sessions of resistance exercise.And to protect your life and the lives of others, don't visit any of these 35 Places You're Most Likely to Catch COVID.

Michael Martin

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The #1 Source of Diabetes, According to Science Eat This Not That - Eat This, Not That

CHICAGO Eduardo Bruera, M.D., chair of Palliative Care Medicine at The University of Texas MD Anderson Cancer Center, has received the American Society of Clinical Oncology (ASCO) Walther Cancer Foundation Supportive Oncology Award. Bruera was formally recognized today at the 2022 ASCO Annual Meeting during the Mentorship and Career Development Roundtable.

The Walther Cancer Foundation Supportive Oncology Award is one of the highest honors presented by ASCO and Conquer Cancer, the ASCO Foundation. Endowed by the Walther Cancer Foundation, a private foundation that supports and promotes interdisciplinary and inter-institutional bench and clinical cancer research, the award and lecture were established to recognize a distinguished lecturer and leader who has made multiple, significant and enduring contributions to palliative and supportive care in oncology through the prevention, assessment and management of cancer- and treatment-related suffering.

I am honored to receive the award and to have ASCO recognize the importance of clinical and research programs aimed at alleviating the physical and psychosocial suffering associated with cancer, said Bruera, who holds the F.T. McGraw Chair in the Treatment of Cancer. We are committed to continuing our efforts to build upon these structures and processes for the benefit of our patients.

As an internationally renowned leader in the field, Bruera has made innumerable contributions to palliative and supportive care with significant impacts on the quality of life for patients with cancer and their families.

He established the Department of Palliative, Rehabilitation and Integrative Medicine at MDAnderson in 1999. Under his leadership, the department has become the largest clinical and academic palliative care program in the world, with an interdisciplinary outpatient Supportive Care Center and both inpatient and outpatient Palliative Care programs. These serve as a model for other institutions, nationally and internationally. The programs structures, processes and outcomes are shared with faculty and leaders of cancer centers across the country and have been reported in peer-reviewed journals and scientific meetings, including the ASCO Annual Meeting and ASCO Palliative Care Symposium.

Dr. Bruera is recognized as an outstanding clinician scientist, a dedicated leader and a passionate educator, said Peter WT Pisters, M.D., president of MD Anderson. Through his leadership, unwavering commitment and pioneering work, his profound contributions have increased the visibility and integration of palliative care into oncology care on a local, national and international level. We are proud that he is receiving this prestigious recognition by ASCO.

Throughout the course of Brueras distinguished career, he has pioneered practice-changing discoveries that have transformed the delivery of modern palliative care and helped to alleviate suffering for patients affected by cancer.

He developed methodologies and conducted research studies instrumental in establishing routine clinical practices in supportive and palliative care including patient-reported outcomes measurement, methylphenidate for opioid sedation and fatigue, opioid rotation and methadone for refractory pain. In addition, he established strategies for corticosteroids for fatigue and symptom control, assessment and management of delirium, opioids and oxygen for dyspnea, and the screening and management of chemical coping and opioid use disorders in cancer patients.

Bruera led numerous research studies aimed at improving the quality of life for cancer patients. He developed and validated the Edmonton Symptom Assessment Scale (ESAS) decades before patient-reported outcome measurements became fully accepted. The ESAS is designed to assist in the assessment of nine symptoms common in cancer patients and provides a clinical profile of symptom severity over time. The tool has been translated into 60 languages and is currently the most commonly used tool for symptom assessment of palliative care and cancer patients worldwide. Bruera made ESAS available free of charge for anyone to use.

Bruera has authored more than 1,075 papers in top peer-reviewed journals, such as The Lancet, Lancet Oncology, JAMA, JAMA Oncology, JAMA Internal Medicine, Journal of Clinical Oncology and Cancer, as well as co-authored Dying in America. Bruera is a frequently invited speaker at national and international scientific conferences, and he has delivered over 900 invited lectures to major cancer centers and supportive and palliative care congresses.

Dr. Bruera has been a longstanding preeminent leader in palliative and supportive care, said Christopher Flowers, M.D., division head ad interim of Cancer Medicine. His dedication and service in this field has had a tremendous impact on patients at MD Anderson and around the world, and he continues to advance research and initiatives to improve their lives.

- 30 -

About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. The institutions sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 52 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is No. 1 for cancer in U.S. News & World Reports Best Hospitals rankings and has been named one of the nations top two hospitals for cancer since the rankings began in 1990. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).

2022 The University of Texas MD Anderson Cancer Center

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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ASCO honors Eduardo Bruera, MD, with Walther Cancer Foundation Supportive Oncology Award - EurekAlert

By Andrew L. Salner, MD, FACR, FASTRO

Medical Director, Hartford HealthCare Cancer Institute at Hartford Hospital

The number of cancer survivors living in the United States continues to increase each year as a result of updated early-detection practices and treatment advances, as well as aging of the population. In 2019, an estimated 17 million Americans were cancer survivors. According to researchers at the American Cancer Society, that number is expected to increase to some 22 million by the year 2030.

The most common diagnoses for female survivors are:

The most common diagnoses amongst male survivors are:

These numbers do not include the large number of patients who have experienced non-melanoma skin cancer (basal cell and squamous cell cancer) or non-invasive bladder cancer.

Of the 17 million survivors, over two-thirds were diagnosed and treated more than five years ago, and 18 percent have been surviving their disease for over 20 years. More than two-thirds of the survivors are age 65 or over, while 10 percent are younger than 50. Approximately 52 percent of survivors are female.

Cancer is a common disease some 43 percent of us will receive the diagnosis during our lifetime. As early detection and treatment continue to improve, the number of survivors will grow each year. The overall five year survival rate from a cancer diagnosis has increased from 49 percent in 1975, to 63 percent in 1995, to close to 70 percent today. While we celebrate these milestones, we realize we still have much more work to do in developing new prevention strategies, screening techniques and therapies. In addition, we also understand that cancer survivorship has associated with it a complex set of issues that require attention on many fronts.

Enduring a cancer diagnosis and therapy not only affects patients physically, it can also impact them emotionally, socially and spiritually. From the physical perspective, treatment can commonly disrupt a patients quality of life due to short and long term side effects including fatigue, pain, sleep disturbance and functionality. Emotional and psychological wellbeing may be impacted by fear of recurrence, anxiety, depression, concentration and memory issues. Social wellbeing may be impaired due to impacts on relationships with others, and issues of intimacy and sexuality. Spirituality may be impacted by ones enhanced hope and resilience or the impairment thereof due to despair.

Other challenges facing survivors include a slightly increased risk of second cancers, the importance of continued surveillance for the initial cancer diagnosis, and the possible presence of financial hardship as a result of the treatment journey, even when medical insurance is present, due to lost work opportunity and other associated costs.

Cancer survivors have an opportunity to help improve their quality of life and possibly reduce the risk of recurrence by adopting healthy behaviors such as:

Hartford HealthCare providers monitor patients for late effects of treatment, and suggest strategies to help cope with a wide array of these survivorship issues. In addition, specific resources are available to help patients overcome these obstacles. For example, a survivorship APRN helps patients by presenting a survivorship care plan designed to present a personalized list of potential issues for patients who so desire. Psychologists and social workers provide counseling to help patients deal with the emotional impact of the experience.

Other resources available include dietary counseling, smoking cessation and integrative medicine strategies such as massage therapy, yoga, acupuncture and Reiki, all designed to help deal with some of the physical and emotional effects of therapy. Your oncology team can help make the referrals for these services as needed.

Articles in our monthly newsletter will provide more detailed information as we dive into survivorship issues related to each type of cancer diagnosis and intervention. At the Hartford HealthCare Cancer Institute, we are committed to your long term wellness.

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Going Beyond Treatment - Hartford HealthCare's Cancer Institute Fights for Survivors - Health News Hub

Michael Glick: ADI International Dentist of the Year for 2021

Michael Glick, Executive Director of Penn Dental Medicines Center for Integrative Global Oral Health, was named the Academy of Dentistry Internationals International Dentist of the Year for 2021. The award honors career contributions to dentistry, international education, and service.

Dr. Glick has been active with the FDI World Dental Federation since 2007, serving on multiple committees. He also had a leading role in establishing FDIs Vision 2020 and most recently was the primary author of its Vision 2030, giving guidance for a global interdisciplinary and integrative role for oral health. Dr. Glick served as Editor-in-Chief of The Journal of the American Dental Association from 2005 to 2020.

Dr. Glick served as Dean of the University at Buffalo, SUNY, School of Dental Medicine (2009-2015) where he remained as professor of oral diagnostic Sciences before coming to Penn Dental Medicine in 2021 to lead Penn Dental Medicines new Center for Integrative Global Oral Health (CIGOH). The schools first policy center, CIGOH is seeking to find creative solutions to address unmet oral health needs around the world through public policy, education, and research initiatives, collaborating across disciplines and across borders.

The ADI will present the award at its 2022 annual meeting (delayed a year due to the COVID-19 pandemic), to be held in November in San Antonio, Texas. Dr. Glick was also invited to present a continuing education lecture as part of the meeting.

The ADI is an international honor society for dentists dedicated to sharing knowledge in order to serve the dental health needs and to improve the quality of life of people throughout the world.This transnational organization is devoted to the advancement of dentistry throughout the world and to the elevation of dental standards by continuing education. There are chapters and fellows in over 80 countries around the world.

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Michael Glick: ADI International Dentist of the Year for 2021 - U Penn

TORONTO--(BUSINESS WIRE)--Cybin Inc. (NEO:CYBN) (NYSE American:CYBN) (Cybin or the Company), a biopharmaceutical company focused on progressing Psychedelics to Therapeutics, is pleased to announce the publication of a peer-reviewed article introducing EMBARK, a model of psychedelic-assisted psychotherapy that integrates leading clinical approaches to promote effective facilitation and supportive healing with psychedelic medicines.

Its a pleasure to see our work published in this respected journal. In developing EMBARK, we looked at 17 models of psychedelic-assisted psychotherapy, and we noticed that many are missing critical elements: a focus on ethics, on human relationships, on the body as a site of somatic healing, and on evidence-based practices. We designed EMBARK to overcome some of these limitations as an integrative model of psychedelic therapy. Wed like to honor the contributions of many teachers and leaders in the field who have helped chart this course, said Alex Belser, PhD, EMBARKs co-creator and Cybins Chief Clinical Officer.

The article was published on June 2, 2022 in the peer-reviewed journal Frontiers in Psychology and is titled, Models of Psychedelic-Assisted Psychotherapy: A Contemporary Assessment and an Introduction to EMBARK, a Transdiagnostic, Trans-Drug Model. Written by EMBARKs co-creators, Bill Brennan, PhD and Alex Belser, PhD, Cybins Chief Clinical Officer, the article provides a detailed overview of EMBARK to the academic and clinical communities. Frontiers in Psychology is the largest journal in the field of psychology.

We are excited to present our model to the field in a way that highlights its thoughtfulness and responsiveness to current concerns in psychedelic research. We have listened carefully to what has worked, and what has been found lacking, and offer EMBARK as an innovative step forward, said Bill Brennan, PhD, EMBARKs co-creator.

The article also provides an overview of EMBARKs six clinical domains (Existential-Spiritual, Mindfulness, Body Aware, Affective-Cognitive, Relational, and Keeping Momentum) and highlights the strengths and limitations of existing psychedelic-assisted psychotherapy approaches and evidence-based therapies. The article is the first of a series of publications aimed at presenting EMBARK as an open-source model of practice and training for therapists and facilitators supporting psychedelic-based treatments.

If psychedelics are ever to be integrated into modern clinical medicine, the usage protocols are as important as the medicines themselves. In this respect Cybin is a leader. Cybin has assembled a faculty of top-notch therapists to lead its EMBARK program, which incorporates a multi-dimensional approach to therapies that enable them to be tailored to a variety of patient needs. With the implementation of EMBARK, Cybin is setting high standards for the future of psychedelic therapy, said Dennis J. McKenna, Ph.D., Founding Board Member of Heffter Research Institute and President and Principal Founder of McKenna Academy of Natural Philosophy.

The article can be accessed online here.

Cybins upcoming clinical trials evaluating the Companys proprietary psychedelic-based molecules CYB003 and CYB004 for treating major depressive disorder, alcohol use disorder, and anxiety disorders will use EMBARK to support study participants.

About CybinCybin is a leading ethical biopharmaceutical company, working with a network of world-class partners and internationally recognized scientists, on a mission to create safe and effective therapeutics for patients to address a multitude of mental health issues. Headquartered in Canada and founded in 2019, Cybin is operational in Canada, the United States, the United Kingdom and Ireland. The Company is focused on progressing Psychedelics to Therapeutics by engineering proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens for mental health disorders.

Cautionary Notes and Forward-Looking Statements

Certain statements in this press release constitute forward-looking information. All statements other than statements of historical fact contained in this press release, including, without limitation, statements regarding Cybins future, strategy, plans, objectives, goals and targets, and any statements preceded by, followed by or that include the words believe, expect, aim, intend, plan, continue, will, may, would, anticipate, estimate, forecast, predict, project, seek, should or similar expressions or the negative thereof, are forward-looking statements. Forward-looking statements in this news release include statements regarding the Companys proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens to potentially treat psychiatric disorders.

These forward-looking statements are based on reasonable assumptions and estimates of management of the Company at the time such statements were made. Actual future results may differ materially as forward-looking statements involve known and unknown risks, uncertainties, and other factors which may cause the actual results, performance, or achievements of the Company to materially differ from any future results, performance, or achievements expressed or implied by such forward-looking statements. Such factors, among other things, include: implications of the COVID-19 pandemic on the Companys operations; fluctuations in general macroeconomic conditions; fluctuations in securities markets; expectations regarding the size of the psychedelics market; the ability of the Company to successfully achieve its business objectives; plans for growth; political, social and environmental uncertainties; employee relations; the presence of laws and regulations that may impose restrictions in the markets where the Company operates; and the risk factors set out in the Company's management's discussion and analysis for the period ended December 31, 2021 and the Company's listing statement dated November 9, 2020, which are available under the Company's profile on http://www.sedar.com and with the U.S. Securities and Exchange Commission on EDGAR at http://www.sec.gov. Although the forward-looking statements contained in this news release are based upon what management of the Company believes, or believed at the time, to be reasonable assumptions, the Company cannot assure shareholders that actual results will be consistent with such forward-looking statements, as there may be other factors that cause results not to be as anticipated, estimated or intended. Readers should not place undue reliance on the forward-looking statements and information contained in this news release. The Company assumes no obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors, should they change, except as required by law.

Cybin makes no medical, treatment or health benefit claims about Cybins proposed products. The U.S. Food and Drug Administration, Health Canada or other similar regulatory authorities have not evaluated claims regarding psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds. The efficacy of such products has not been confirmed by approved research. There is no assurance that the use of psilocybin, psychedelic tryptamine, tryptamine derivatives or other psychedelic compounds can diagnose, treat, cure or prevent any disease or condition. Rigorous scientific research and clinical trials are needed. Cybin has not conducted clinical trials for the use of its proposed products. Any references to quality, consistency, efficacy and safety of potential products do not imply that Cybin verified such in clinical trials or that Cybin will complete such trials. If Cybin cannot obtain the approvals or research necessary to commercialize its business, it may have a material adverse effect on Cybins performance and operations.

Neither the Neo Exchange Inc. nor the NYSE American LLC stock exchange have approved or disapproved the contents of this news release and are not responsible for the adequacy and accuracy of the contents herein.

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Cybin Announces Publication in Frontiers in Psychology Journal Introducing EMBARK, an Integrative Model of Psychedelic Therapy - Business Wire

Newswise Irvine, CA May 31, 2022 A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues and that the organs and processes muscle impacts are markedly different between males and females. This new discovery provides insight into how muscle functions, such as exercise, promote healthy longevity, metabolism and improve cognition.

The study, titled, Genetic variation of putative myokine signaling is dominated by biologic sex and sex hormones, published in eLife, is the first to evaluate how genetic architecture influences muscle signaling to other tissues, highlighting that sex and estrogens are critical determinants of these processes.

Muscle is criticalfor maintaining metabolic state and disruption of musclefunction is a hallmark of diseases such as obesity, type 2 diabetes and cardiovascular disease, said senior author Marcus M. Seldin, PhD, assistant professor of biological chemistry at UCI School of Medicine.

Muscles secrete proteins called myokines, which play roles in a variety of processes by interacting with other tissues. Essentially, myokines allow skeletal muscles to communicate with organs such as the kidneys, the liver or the brain, which is essential for the body to keep its metabolic balance. Some of the process myokines are involved include inflammation, cancer, the changes brought about by exercise, and even cognition. Despite the clear relevance of myokines to so many physiological outcomes, the way these proteins are regulated and their effects are not well understood.

For this study, the research team performed a survey of genetic correlations focused on myokine gene regulation, muscle cell composition, cross-tissue signaling and interactions with genetic sex in humans. While expression levels of a majority of myokines and cell proportions within skeletal muscle showed little relative differences between males and females, nearly all significant cross-tissue enrichments operated in a sex-specific or hormone-dependent fashion; in particular, with estradiol. These sex- and hormone-specific effects were consistent across key metabolic tissues: liver, pancreas, hypothalamus, intestine, heart, visceral and subcutaneous adipose tissue. This study highlighted a few examples such as that muscle signals more to the pancreas in females, compared to males where liver is dominant.

We already know that skeletal muscle plays an integral role in coordinating physiologic homeostasis. In this study, we sought to understand how muscle interacts with metabolic tissues and illustrate the importance of considering the effects of genetic sex and sexual hormones when studying metabolism, said Seldin.

Moving forward, the research team plans to generate cell-based systems to evaluate some of the new hormones uncovered as part of this study and investigate why they signal differently between sexes.

This work was supported by the National Institutes of Health.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA, an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

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New UCI-led study finds that your genetic sex determines the way your muscle talks to other tissues in your body - Newswise

Richmond Hill, Ontario, Canada June 3, 2022

Pantea Kalhor, the founder of Acechoice Publishing and Branding, 5 times amazon best-selling author, Functional Diagnostic Nutrition Practitioner, certified fertility and PTSD coach along with seven other health experts published her fifth book, The Gap: Simple Steps to Reclaim Your Health and Reverse Most Chronic Diseases.

Health gurus talk about different approaches to how to live a happy, healthy life by discovering healing opportunities in the body. The experts in this book explain how one can find true healing if research is extended, goes deeper, and looks at the big picture, at the body as a whole.

This book is the missing link, the piece of the puzzle that holds the answers youve been searching for. Its The Gap between chronic disease and your true recovery. said Pantea.

So many in the world today suffer from a myriad of conditions that are treated with a high consumption of medications over long periods of time. These only create a temporary relief from the pain and symptoms, and do not truly heal the root cause. With The Gap, readers are able to learn how the body, mind, and spirit connect. Discover how a high level of understanding about this interconnection can improve recovery from chronic pain.

Once again, Pantea has created a valuable resource for all who want to find answers to their health issues, a collaboration of experts who started off and highly trained medical and integrative medicine professionals that turned to natural, holistic practices to find the root causes of illness in their field. reviewed Angela Curtis, a best-selling author and editor.

Pantea Kalhor is also a show host, podcaster and the survivor of a Carjacking accident and unexplained infertility. Both traumas immensely affected her life and encouraged her to write four books regarding Mind-Body connection healing: Rules of Change for the Better, Naturally Conceived, PTSD Compass and The GAP. She helps women who are struggling with fertility issues remove their mental and physical blockers by filling the gap between mind and body connection.

To uncover the mystery surrounding chronic disease and to learn how your body can live healthier and longer, please visit https://acechoiceidea.com/funnel/the-gap/landing-page/ to read The Gap and download your freebies.

As the founder of Ace Choice Publishing & Branding: http://acechoiceidea.com, Pantea Kalhor also helps authors share their messages by supporting them in publishing and distributing their own book or becoming co-authors in their best seller books, and get featured in top media placements.

About Us: AceChoice Publishing and Branding helps authors write, publish, and distribute their books to bookstores and libraries. Authors learn how to publish and market their own book to the best ranking in amazon. They can also take the shortcut and only write 2500-3000 words by participating in our book projects, get connected with other coauthor experts and get high exposure in shows, podcasts, and media outlets. By getting help from Acechoice, authors can not only publish their books but also become speakers, be more visible in media and build their business foundations.To find out if you are eligible to participate in our book project, please visit the company website: http://acechoiceidea.com

Contact Info: Name: PANTEA KALHOREmail: Send EmailOrganization: AceChoice Publishing and BrandingAddress: 363 browndale crescentPhone: 14168805527Website: http://Acechoiceidea.com

Video URL: https://youtu.be/jQOfca1K_Bk

Release ID: 89075748

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Pantea Kalhor's Book The Gap: Simple Steps to Reclaim Your Health and Reverse Most Chronic Diseases is Now Available on Amazon and Online Bookstores....

Since 2008, City Of Angels has been helping people deal with addiction and recovery throughout New Jersey. They were instrumental in helping Artie Lange go into rehab.

Many times their founder Kevin Meara will be in studio talking about addiction or co-hosting one of our games only to hit the phone during a commercial break to help an addict trying to get help.

One night he sent chills down our spine when he pulled 23 holy cards out off his pocket representing the funeral he attended that month.

Now City of Angels is expanding to help out veterans with the Fr Vincent R Capodanno Veterans Research and Wellness Initiative at City Of Angels. Meara explains:

"For some time City of Angels has been working on an initiative to enhance our existing veteran's program -Warrior Down, No Vet Left Behind".

Kevin with two marines who were on the battlefield when Fr Capodanno was KIA

"We call that enhancement. The Father Vincent R Capodanno Veterans Research and Wellness Initiative at City of Angels or Father Vincents. The mission of our Initiative is to drive advances in and access to research and integrative medicine which addresses our veterans mental health and substance use disorders. Keeping with the service and sacrifice of Father Capodanno no veteran is denied access due to status, religion, or race.

"Born of our Warrior Down -No Vet Left Behind program, no veteran will ever receive a bill from Father Vincents. COA believes that wellness, through initiatives like integrative medicine, is the missing link to addressing mental health and substance use disorders."

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"When COA started in 2008, relapse was inconvenient, but now relapse is deadly. So its not rocket science that relapse can be prevented if recovery can be extended. Wellness concepts, including mental, physical and spiritual, can prevent relapse. Integrative medicine such as Hyperbarics and Ketamine Infusions, which promote neurogenesis and are supported by counseling, meditation, massage therapy, nutrition and yoga, are leading-edge."

Why was it named for Father Capodanno?

"It was something that I have no explanation for other than we were blessed by the Capodanno family, as Vinnie Capodanno (Father Vincent's namesake and a close friend) suggested we use his uncle's name."

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What made City of Angels take this on?

"Veteran addiction numbersmore veterans are dying from suicide than combat! This was an extension of our current veteran program Warrior Down, which was initiated when vets were coming home from Iraq and Afghanistan. It was simply the right thing to do!"

What can be done to fight mental illness?

'The number one thing to do is recognition followed by awareness. After that, if things arent working, do something different and we believe this is something different. This is leading-edge."

Vinnie Capodanno

How would you like City Of Angels to resemble St Judes?

"Every St Judes commercial states no child in need will be turned away. We believe every veteran in need should get the help they deserveits basic human compassion!"

Opinions expressed in the post above are those of New Jersey 101.5 talk show host Steve Trevelise only. Follow him on Twitter @realstevetrev.

You can now listen to Steve Trevelise On Demand! Discover more about New Jerseys personalities and what makes the Garden State interesting. Download the Steve Trevelise show wherever you get podcasts, on our free app, or listen right now.

Click here to contact an editor about feedback or a correction for this story.

See the Must-Drive Roads in Every State

A trip to New Jersey doesn't have to be all about the beach. Our state has some incredible trails, waterfalls, and lakes to enjoy.

From the Pine Barrens to the Appalachian Trail to the hidden gems of New Jersey, you have plenty of options for a great hike.Hikingis such a great way to spend time outdoors and enjoy nature, plus it's a great workout.

If you are going downhill and run into an uphill hiker, step to the side and give the uphill hiker space.Ahiker going uphill has the right of way unless they stop to catch their breath.

Always stay on the trail, you may see side paths, unless they are marked as an official trail, steer clear of them. By going off-trail you may cause damage to the ecosystems around the trail, the plants, and wildlife that live there.

You also do not want to disturb the wildlife you encounter, just keep your distance from the wildlife and continue hiking.

Bicyclists should yield to hikers and horses. Hikers should also yield to horses, but Im not sure how many horses you will encounter on the trails in New Jersey.

If you are thinking of bringing your dogon your hike, they should be leashed, and make sure to clean up all pet waste.

Lastly, be mindful of the weather, if the trail is too muddy, it's probably best to save your hike for another day.

Iasked our listeners for their suggestions of the best hiking spots in New Jersey, check out their suggestions:

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City of Angels to help NJ veterans regardless of situation - New Jersey 101.5 FM

Summer is around the corner, although sometimes it seems like we live in an eternal summer in the Magic City; however, pool and boat activities are back in full swing. And in a glamorous city like Miami, you have to look your best and have a fabulous time. Below you will find the best tips to serve a snatched body and face, wear the best outfit and relax. We have you covered, so get ready to enjoy the fun water activities and parties!

See Also: Capittana Capsule Swimwear Collection To Launch At Nikki Beach

There is nothing better than toning your body with a good workout and getting your body ready for the pool and the boat. Some may call it the revenge body because it will have some people talking about it. So below, we have some great recommendations for a much-needed workout. And if you don't like going to gyms, we have some fantastic outdoor destinations to start your fitness journey inside or outside.

Multiple Locations / Website

With multiple locations in South Florida, and the country, this is a great place to work on that summer body. Here not only will you find HIIT+ workouts,Group Classes, Affordable Personal Training, but also nutrition guidance using the latest technology and top notch fitness equipment.

Multiple Locations / Website

Anatomy provides a complete three-phase personal training system, performed by expertly trained Body Architects, to help members achieve their fitness goals. Here you will find hot and cold plunge pools, infrared and cold saunas, a eucalyptus steam room, and more. This gym is a holistic wellness experience for all members, making breaking a sweat even more enjoyable.

Arthur Lamb Jr. Road / Website

For those who love working in nature with fresh air and peacefulness, Virginia Key North Point Trails has options for everyone. The trail is a 4-mile loop that is different at every turn, with elevation and beautiful scenery.

1 Washington Ave / Website

Nothing gets more Miami than South Pointe Park. Here you can run, walk, meditate, and more if you are an outdoors lover while enjoying some of the most fantastic views of the city and the water. If you are lucky, you might wave to cruisers leaving the port. When you are ready to cool down, take a dip at the nearby beach.

Whether you choose to work out inside of a gym or outside, Miami will inspire you to get your body ready for the summer.

To look your best at the pool or on the boat, you need to give yourself new skin, to achieve this, there is nothing better and more accessible than exfoliating. Just be careful not to overdo it and ready the instructions before using some of the best exfoliators for the body, scalp, and face that we recommend below.

Price: $70 / Website

One of the best body scrubs on the market, the Detoxifying Body Scrub penetrates deeply to extract everything from clogged pores. Ingredients like Aloe vera moisturizes, and avocado softens skin to balance things out so it doesn't feel dry and tight after scrubbing. After using it, your skill will feel so smooth.

Price: $80 / Website

This is definitely a facial because it does, in fact, leave your skin looking like you just had a professional treatment. Credit a combination of alpha-hydroxy and beta-hydroxy acids (glycolic, tartaric, lactic, citric, and salicylic) for smoothing the texture of your skin and helping to minimize the appearance of fine lines and wrinkles. Because the product is specially formulated to have a pH of 3.5, it is especially effective without causing redness or sensitivity. It also includes a vial of the brand's organic marula luxury face oil.

Even if you tan under the sun, there is no limit to your summer glow. However, it's always better to protect your skin and fake-tan using the best products. So, to take that sun-kissed golden look to the next level, we have some recommendations that will have people wondering if you are a sun princess.

Price: $40 / Website

You can never go wrong with a St. Tropez tanning product. The fragrance noses at Givaudan were enlisted to create a powdery floral aroma that doesn't make you want to hold your breath until it's time to shower. After misting and blending it with a mitt, you should wait for one to three hours before rinsing it off for a light, medium, or dark tan. It dries instantly, so feeling sticky is never an issue. Eight hours after applying and rinsing, the results are tanned skin with no streaks just like your own skin, only healthier.

Price: $60 / Website

This quick and easy self-tanning concentrate works with any moisturizer or body butter to produce a natural-looking, hydrated, and golden tan. It provides all-day hydration thanks to naturally derived raspberry seed oil, vitamin E, and aloe vera. It's easy to use, and you will look so good after using it. P.s., don't forget to use the face version of this wonderfould product.

To keep your skin looking fresh, you always have to moisturize. And sometimes, being under the sun and with salty water around you, your skin can dry out, which is why this step is essential. Below, we present you with some of the best moisturizers to look like you came out of a facial treatment at a luxurious spa.

Price: $60 / Website

This lightweight, clarifying water cream contains hydrating nutrients and pore-refining botanicals that promote healthy aging and smooth, balanced skin. Whether you are prone to dry skin, or you simply want to give your skin an extra boost of hydration, this is a great alternative.

Price: $39 / Website

The skin-perfecting goodness of Glow Recipe's Refillable Plum Plump Hyaluronic Cream is further proof that it is one of the Internet's buzziest brands with the brightest formulas. The whipped gel-cream gets its gorgeous lavender color from three different types of plums (kakadu, illawara, and Burdekin) and its intense moisture-replenishing powers from five different weights of hyaluronic acid.

Before anything else, apply your SPF. People often forget this crucial step in their skincare routine, but if you want to protect your skin from the sun, and make it look extra fresh, DO NOT skip it. Below you will find some great recommendations so you can enjoy the pool or the boat while protecting your skin.

Price: $19.99 / Website

It is known that most sunscreens containing only physical UV blockers are notorious for being harder to spread and more visible on the skin than those containing chemical UV filters, Blue Lizard's Sensitive Mineral Sunscreen SPF 50+ formula spreads and absorbs well. This sunscreen, which has both zinc oxide and titanium dioxide, provides broad-spectrum UVA and UVB protection. Blue Lizard claims that this fragrance-free formulation is sweat and water-resistant for 80 minutes (the highest such claim allowed by the FDA). It comes in bottles that change color (from white to blue) when exposed to harmful UV light.

Price: $49 / Website

Powered by SynchroShieldTM Technology, this lightweight, invisible protective veil provides maximum protection for active, outdoor activities when it detects water, sweat, or heat*. This sunscreen lotion applies evenly and protects against UVA/UVB rays, pollutants, and dryness. This SPF always makes it to the best lists, so it is a must-have and key to protecting your skin.

To some, the summer is bikini season. With all the great tips you will find here to get yourself ready to enjoy those pool and boat activities, it is only appropriate to show up with the best swimwear. Below you will find two great boutiques in Miami to meet all of your bikini needs.

1006 Lincoln Road / Website

Beach Bunny celebrates every woman's style in an undeniably playful way, from classic silhouettes to ultra glamorous pieces.

475 Biltmore Way / Website

If you want swimwear that makes you look luxurious while still keeping the fresh and fun vibe of swimwear, this is the boutique for you. Here you will find quality pieces and a wide variety for every day you go to the pool or the boat.

A pair of perfect sunglasses will only enhance your summer activities. They will also keep you looking fly while protecting your eyes, so find some fashionable sunnies that up your game below.

Price: $50 / Website

This Quay bestseller is perfect for the pool, the boat, and beyond. And because square sunglasses have been in for a while, these pairs will make you look fabulous. Also, during the sunset, they will blend perfectly with the colors of the sky.

Price: $163 / Website

You can never go wrong with some classic Rayn Ban sunglasses, and these are the perfect ones for every summer activity. They will make you look classy but trendy at the same time.

To finish off the perfect outfit, you need the ideal shoes. And although you can use any comfortable shoes you have at home, we have some great recommendations to up your pool and boat activities vibes. But regardless, you can wear those iconic sandals you have at home because you will probably not need them that much anyway.

Price: $140 / Website

The Arizona Soft Footbed Sandal from Birkenstock combines fashion and function. These sandals' iconic double strap uppers are crafted from premium suede leather. The Soft Footbed design offers lightweight cushioning with an additional layer of soft foam inserted between the cork midsole and suede liner for maximum support and comfort. Available in multiple colors, these sandal is a great option.

Price: $248 / Website

Tory Burch's logo-emblazoned Miller sandals are a good option for a flip flop with a little more oomph. The circular logo at the top is so fashionable, it keeps your foot in place a little better than traditional flip-flops. They come in a variety of classic colors and on-trend patterns.

Don't forget to top your look with your favorite jewelry pieces and a classic big hat perfect for an Instagram photo shoot.

Lastly, before you enjoy any pool or boat activities, you should take some time to relax, whether the day before or the same day before your activities. Because getting ready for fun activities requires a clear mind and relaxation to have an even better time enjoying the summer. Relaxing is part of a healthy balance wherever you go to a spa or meditate. We have you covered with some fantastic options!

Multiple Locations / Website

This internationally recognized spa and fitness superbrand and total well-being hot spot will help you relax, look and feel your best to prepare you for the pool and boat activities. And during Spa Month in Miami, exhale has some fantastic deals, so your relaxation doesn't stop. Don't forget to check it out with multiple locations throughout the region.

1901 NE 168th St. / Website

Helia House, located in North Miami Beach, embodies energy and vitality. It's a place to heal, reconnect with yourself, and find refuge from the daily chaos. Helia House was envisioned and designed by Dr. Elizabeth Trattner, a wellness and beauty expert who specializes in Chinese and Integrative medicine. A perfect place to relax and get your mind and body ready for summer activities.

Photography by: Courtesy Anna Demianenko/ Unsplash, Angello Pro/Unsplash, bruce mars/Unsplash, Amplitude Magazin/Unsplash, Drew Dau/ Unsplash, Poko Skincare/Unsplash, Onela Ymeri/Unsplash, Arturo Rivera/Unsplash, Charlota Blunarova/Unsplash, Jakob Owens/Unsplash, engin akyurt/ Unsplash

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How To Get The Best Summer Look For Miami Pool And Boat Parties - Ocean Drive | Modern Luxury