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OSE Immunotherapeutics Announces New European Patent Granted Covering CLEC-1, Novel Myeloid Immune Checkpoint Target For Cancer Immunotherapy

Posted: May 2, 2022 at 2:43 am

NANTES, France, May 02, 2022 (GLOBE NEWSWIRE) -- OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) today announced the grant of a new patent from the European Patent Office (EPO) strengthening the protection covering its novel myeloid cell immune checkpoint target, CLEC-1 (a C-type lectin receptor), and its use in cancer treatment. This patent provides a protection until 2037.

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OSE Immunotherapeutics Announces New European Patent Granted Covering CLEC-1, Novel Myeloid Immune Checkpoint Target For Cancer Immunotherapy

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Nicox at ARVO 2022: Presentation of clinical Phase 2 results on NCX 4251 and new non-clinical evidence of improved hemodynamic and retinal cell…

Posted: May 2, 2022 at 2:43 am

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Nicox at ARVO 2022: Presentation of clinical Phase 2 results on NCX 4251 and new non-clinical evidence of improved hemodynamic and retinal cell...

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Dreams on Fire sheds light on epigenetics, collective trauma of genocide traveling through generations – Armenian Weekly

Posted: May 2, 2022 at 2:41 am

NEW YORK, NY Set before the 2016 presidential elections,Dreams on Fire, a groundbreaking play by Professor Jan Balakian and directed by Nora Armani, explores college students, mental health and the transmission of trauma in history across generations via the Armenian Genocide.

The play traces back the causes of Aram Sarkissians anxiety and mental health issues to intergenerational trauma through epigenetics. While the subject is dark, the characters are full of life and humor. The story takes place in Fort Lee, NJ and in retrospect prophetically refers to the four years of disastrous leadership that await the US. Arams grandmother Hripsime recounts the experiences of her own mother, surviving the Genocide as a young woman, and how she ends up in the US.

The riveting tale links the past to the present and explains mental health today as it is traced back to past trauma, even if such trauma has not touched the victim directly. Never before has there been a play that explores college students, mental health and the Armenian Genocide within the context of the 2016 election.

The cast of the Zoom reading includes Constance Cooper,Sam Arthur,Emma Giorgio andDalita Getzoyan. Donna Heffernan is assistant director. The reading, which is open to the public, will take place onWednesday, April 27, at 5:00 PM EDT presented as part of the Kean University Research Day activities. A Q&A session with Balakian, faculty members and attendees will follow the reading. FREE and open to the public.

The Armenian Genocide perpetrated by Ottoman Turkey on the Armenians is a fact widely substantiated by historians, archivists and eyewitnesses whose accounts have been recorded and preserved. And yet, the countries who have officially recognized it are few, mainly to appease Turkey.

US presidents, under pressure from Turkey, have played word gymnastics calling the events by several different names, shying away from its correct name of Genocide. President Joe Biden acknowledged the Armenian Genocide in 2021, and this year, on the 107th anniversary of the commemoration, confirmed that the events that started on April 24, 1915 and lasted until 1923, were in fact Genocide, causing the death of over 1.5 million Armenians and wiping out an entire population from its ancestral lands.

Guest contributions to the Armenian Weekly are informative articles or press releases written and submitted by members of the community.

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Dreams on Fire sheds light on epigenetics, collective trauma of genocide traveling through generations - Armenian Weekly

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Digital biomarkers – An Emerging tool in precision Medicines. The Biomarkers Market to Reach $86 Billion by 2027 – Arizton – Yahoo Finance

Posted: May 2, 2022 at 2:41 am

SIRIUS MANAGEMENT CONSULTING

The global biomarkers market was valued at $45 billion in 2021 and is expected to reach $86 billion by 2027.

Chicago, April 27, 2022 (GLOBE NEWSWIRE) -- According to the latest research report by Arizton, the biomarkers market will grow at a CAGR of over 11% during 2022-2027. Digital biomarkers have become an exciting new tool for advancing precision medicine and supporting clinical trials. They are collected using digital devices that are portable, wearable, implantable, or digestible. Digital biomarkers can be objective, quantifiable, physiological, and behavioral measures. Digital biomarkers have majorly impacted the neurology field. In neurology, several digital biomarkers are being tested for feasibility and reliability in Parkinsons and Alzheimer's disease and clinical outcome assessments.

With the emergence of innovative technologies, the identification and validation of a biomarker are becoming key elements of personalized medicine. For example, in cancer, personalized medicine uses specific biomarker information that has been measured from a persons tumor to help plan treatment regimes, monitor a treatments response, or aid in determining a prognosis.

BIOMARKERS MARKET REPORT SCOPE

REPORT ATTRIBUTE

DETAILS

MARKET SIZE (2027)

$86 Billion

CAGR (2022-2027)

Over 11%

BASE YEAR

2021

FORECAST YEAR

2022-2027

LARGEST MARKET

North America

FASTEST MARKET

Europe

MARKET SEGMENTATION

Indication, Application, Type, and Geography

REGION

North America, Europe, APAC, Latin America, and Middle East & Africa

COUNTRIES COVERED

US, Canada, Germany, France, UK, Italy, Spain, Japan, China, India, South Korea, Australia, Brazil, Mexico, Argentina, Turkey, South Africa, and Saudi Arabia

KEY VENDORS

Abbott, bioMrieux, Biohit Oyj, Centogene, Creative Diagnostics, F. Hoffmann-La Roche, Fujirebio, GE Healthcare, TAmiRNA

Click Here to Download the Free Sample Report

The biomarker approach in developing personalized medicine helps in clinical decisions, personalized therapies, and improved research and development (R&D) models. Developing and providing access to novel personalized medicine products and services are only part of what is needed to achieve better human health by tailoring treatment based on the presence or absence of specific biomarkers.

Story continues

Increased Discovery of Epigenetic Biomarkers in Oncology

Epigenetics, genomic, and epigenomic technologies have opened new and promising landscapes for healthcare professionals, enabling them to diagnose and monitor diseases more precisely, effectively, and rapidly. It is obvious that epigenetics is revolutionizing the potential of biomedicine and clinical diagnostics, therefore, contributing to the future development of precision medicine.

Key Offerings:

Market Size & Forecast by Volume | 20212028

Market Dynamics Leading trends, growth drivers, restraints, and investment opportunities

Market Segmentation A detailed analysis by indication, application, type, and geography

Competitive Landscape 9 key vendors and 22 other vendors

To know more! https://www.arizton.com/market-reports/biomarkers-market

Key Insights

Biomarkers in the field of oncology have revolutionized diagnostics and treatment pathways. Oncology indications constitute of largest share because biomarkers are being largely used for cancer research and diagnostics due to their high prevalence worldwide.

Diagnostics dominated the application segment. However, the application of biomarkers in drug discovery & development is expected to grow significantly during the forecast period because biomarkers studies are expected to become an integral part of the drug development process with the aim of developing more effective drugs at a lower cost

North America is the largest market for biomarkers. The increase in R&D expenditures and funding for biomarker-driven drug discovery & development and precision medicine is one of the major driving factors.

APAC is anticipated to exhibit the highest CAGR of 13.96% during the forecast period. Increasing developments and incorporation of advanced technologies to enhance biomarker-based testing and increasing demand for biomarkers in drug development is driving the demand in APAC.

The COVID-19 pandemic had a negative impact on the market. Several biomarkers research activities got postponed as most of the research activities were focused on COVID-19 indications.

Market Segmentation

Indication

Oncology

Cardiology

Neurology

Immunology

Others

Application

Type

Diagnostic Biomarker

Monitoring Biomarker

Prognostic Biomarker

Predictive Biomarker

Susceptibility Biomarker

Other Biomarker

Region

North America

Europe

Germany

France

UK

Italy

Spain

APAC

Japan

China

India

South Korea

Australia

Latin America

Middle East & Africa

Turkey

South Africa

Saudi Arabia

Competition Overview

The biomarkers market is highly dynamic, with the presence of several global, regional, and local players engaged in biomarkers discovery and development in collaboration with several research organizations. The growth of the biomarkers market majorly depends on advancements in technology and investments in R&D to discover and develop more biomarkers. Global players are focusing on developing more biomarkers and expanding their product portfolio to remain competitive in the market. The key players are also engaged in strategic acquisitions as part of their inorganic growth strategy to remain competitive and grow in the market. Through mergers & acquisitions, major players continue to expand their market shares. Furthermore, they are also growing through partnerships and collaborations with several research organizations to develop biomarkers for new testing strategies.

Explore our healthcare lifesciences profile to know more about the industry.

Click Here to Download the Free Sample Report

Read some of the top-selling reports:

About Arizton:

Arizton Advisory and Intelligence is an innovation and quality-driven firm, which offers cutting-edge research solutions to clients across the world. We excel in providing comprehensive market intelligence reports and advisory and consulting services.We offer comprehensive market research reports on industries such as consumer goods & retail technology, automotive and mobility, smart tech, healthcare, and life sciences, industrial machinery, chemicals, and materials, IT and media, logistics and packaging. These reports contain detailed industry analysis, market size, share, growth drivers, and trend forecasts.Arizton comprises a team of exuberant and well-experienced analysts who have mastered in generating incisive reports. Our specialist analysts possess exemplary skills in market research. We train our team in advanced research practices, techniques, and ethics to outperform in fabricating impregnable research reports.

Click Here to Contact Us

Call: +1-312-235-2040+1 302 469 0707

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Digital biomarkers - An Emerging tool in precision Medicines. The Biomarkers Market to Reach $86 Billion by 2027 - Arizton - Yahoo Finance

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NEAR science: good for what ails stressed communities – NUjournal

Posted: May 2, 2022 at 2:41 am

NEW ULM May is Mental Health Awareness Month, and this year the need for mental health education and services has never been higher.

Mental Health Month started in 1949 to increase awareness of the importance of mental health and wellness in Americans lives and to celebrate recovery from mental illness.

After more than two years of societal disruption from the COVID-19 pandemic, this year several Brown County organizations are working to promote the month.

Mental Health Awareness month is represented by a green ribbon. Throughout the month green ribbons will be displayed at the Community Service Building, 1117 Center St. and Brown County drop-in Center, 1113 Center St.

From 9 a.m. to 2:30 p.m. Tuesday, May 3, The Heart of New Ulm Brown County Mental Health and Wellbeing Action Team, in collaboration with the Families First Collaborative of Brown County, will be offering a presentation called Understanding NEAR Science: Building Self-Healing Communities.

The presentation covers the basics of NEAR science which stands for neurobiology, epigenetics, Adverse Childhood Experience (ACE) and resilience a study of the relationship between health risks and behaviors to exposure to adverse childhood experiences. People who experienced abuse, neglect or household dysfunction as a child were more likely to have increased risks of chronic health conditions and death, as well as increased participation in risky behaviors.

Additional research has shown experiences like racism, neighborhood safety, community violence, bullying, and living in foster care can increase the likelihood of increased health risks.

Over the last few decades, research has expanded on what can be done to prevent adverse childhood experiences and how people can move past their experiences to live healthy and safe lives.

The building self-healing communities presentation is intended to start an ongoing communitywide conversation between professionals, law enforcement, parents, faith leaders, educators and neighbors about how to change the narrative of the future of communities.

The Understanding NEAR Science: Building Self-Healing Communities presentation is free and open to the public; however, space is limited, and registration is required. For information and to register, visit https://tinyurl.com/NEARscience.

Similar presentation have been held in Brown County before, but due to the COVID pandemic few public health presentation were possible. The pandemic also created a need for greater need for mental health services as many were impacted by the health crisis.

The Brown County Local Advisory Committee will be hosting a Mental Health Walk Tuesday, May 17, Harman Park in New Ulm. The walk is open to everyone wishing to show support for mental health in the community. Registration for the walk is at 12:30 p.m. at Harman Park. There will be two routes to accommodate differing physical capabilities. The walk will be followed by professional speakers sharing their knowledge and experience regarding mental health recovery.

The local advisory committee is made of members of the public, professionals and providers with an interest in mental health and support in the county. The goal of the committee is to have a conversation about mental health, advocacy, combatting stigma and creating a supportive community for those struggling with their mental health.

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NEAR science: good for what ails stressed communities - NUjournal

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Sprint Bioscience’s NIMA program is focused on the target protein NNMT and will be launched at the BIO International convention – Marketscreener.com

Posted: May 2, 2022 at 2:41 am

Sprint Bioscience today announces that the NIMA program is focused on developing a precision medicine treatment that targets the protein Nicotinamide N-methyl transferase (NNMT). The program will be launched in connection with Sprint Bioscience participating in the pharmaceutical industry's largest annual partnering meeting, BIO International Convention, in San Diego, June 13-16, 2022.

The NNMT gene is overexpressed in multiple cancers and high levels of NNMT is linked to poor prognosis in several tumor types, including gastric cancer, ovarian cancer and glioblastoma. Glioblastoma, which is one of the most aggressive cancers, accounts for about 35 percent of all brain tumors and is thus one of the main challenges in today's cancer care. The median survival for patients with glioblastoma is approximately 1214 months. Gastric cancer is the fifth most common cancer globally and the median survival for metastatic gastric cancer is only 15-17 weeks. Consequently, there is a large remaining unmet medical need for improved treatment alternatives for these indications.We are very pleased with the progress of the NIMA program, which entails atruly promising opportunity to develop a novel cancer treatment alternative. Our fragment-based drug development platform has enabled us once more to rapidly develop highly potent inhibitors of a novel target. We are very much looking forward to introducing the NIMA program to potential partners", said Martin Andersson, Chief Scientific Officer at Sprint Bioscience.About the NNMT protein and cancerThe NNMT protein is upregulated in several cancers and is involved in various important processes in the survival of cancer cells at the interface between epigenetics, tumor metabolism and immunosuppression.

Upregulation of NNMT has been shown to promote tumor growth through epigenetic reprogramming of both cancer cells and stromal cell types in the tumor. Elevated NNMT have also been shown to affect cell metabolism, such as levels of S-adenosylmethionine (SAM) and biosynthesis of NADH. The product produced by NNMT, 1-methylnicotinamide (1MNA), is excreted by tumor cells and inactivates the function of immune cells in the tumor.

Studies have also shown that the ability of CAR-T cells to eliminate tumor cells is affected by 1MNA, which opens up for treatments where NNMT inhibitors can be used in combination with various types of immunotherapies, including cell therapies such as CAR-T.

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Sprint Bioscience's NIMA program is focused on the target protein NNMT and will be launched at the BIO International convention - Marketscreener.com

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Post-Doctoral Associate in the Center for Genomics and Systems Biology job with NEW YORK UNIVERSITY ABU DHABI | 291713 – Times Higher Education

Posted: May 2, 2022 at 2:41 am

Description

The Center for Genomics and Systems Biology (CGSB) at New York University Abu Dhabi (NYUAD) invites applications from individuals to be appointed as a Postdoctoral Associate. The position will be based at NYU Abu Dhabi and supervised by Dr. Kirsten Sadler Edepli.

The Postdoctoral Associate will use bioinformatics tools applied to genomics datasets and experimental approaches to study regeneration, development, or other biological processes. Projects in the Edepli lab integrate datasets from model organisms (mice and zebrafish) to understand how altering the epigenetic landscape promotes or restricts liver regeneration in mice.

Applicants must have a PhD in biological sciences, genetics, genomics, cell biology, physiology, or related fields. Applicants who have sold expertise in epigenetics, epigenomics, and multi-omics and who seek to join a dynamic and creative team of scientists focused on the epigenetic mechanisms regulating regeneration across diverse species will be considered.

The terms of employment include highly competitive salary, housing allowance, and other benefits. Applications are accepted immediately and candidates will be considered until the position is filled. To be considered, all applicants must submit a cover letter, curriculum vitae, transcript of degree, a one-page summary of research accomplishments and interests, and at least 2 letters of recommendation, all in PDF format. If you have any questions, please email:nyuad.cgsb@nyu.edu

About NYUAD:

NYU Abu Dhabi is a degree-granting research university with a fully integrated liberal arts and science undergraduate program in the Arts, Sciences, Social Sciences, Humanities, and Engineering. NYU Abu Dhabi, NYU New York, and NYU Shanghai, form the backbone of NYUs global network university, an interconnected network of portal campuses and academic centers across six continents that enable seamless international mobility of students and faculty in their pursuit of academic and scholarly activity. This global university represents a transformative shift in higher education, one in which the intellectual and creative endeavors of academia are shaped and examined through an international and multicultural perspective. As a major intellectual hub at the crossroads of the Arab world, NYUAD serves as a center for scholarly thought, advanced research, knowledge creation, and sharing, through its academic, research, and creative activities.

EOE/AA/Minorities/Females/Vet/Disabled/Sexual Orientation/Gender Identity Employer

UAE Nationals are encouraged to apply.

Equal Employment Opportunity Statement

For people in the EU, click here for information on your privacy rights under GDPR:www.nyu.edu/it/gdpr

NYU is an equal opportunity employer committed to equity, diversity, and social inclusion.

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Post-Doctoral Associate in the Center for Genomics and Systems Biology job with NEW YORK UNIVERSITY ABU DHABI | 291713 - Times Higher Education

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Guidance for Human Somatic Cell Therapy and Gene Therapy | FDA

Posted: May 2, 2022 at 2:40 am

Docket Number: FDA-2009-D-0132-0016 Issued by:

Guidance Issuing Office

Center for Biologics Evaluation and Research

Since the issuance of the "Points to Consider (PTC) in Human Somatic Cell Therapy and Gene Therapy"in 1991, the range of gene therapy proposals has expanded to include additional classes of vectors and use of vectors in vivo via direct vector administration to patients. This guidance document updates and replaces the 1991 PTC with new information intended to provide manufacturers with current information regarding regulatory concerns for production, quality control testing, and administration of recombinant vectors for gene therapy; and of preclinical testing of both cellular therapies and vectors. These guidances are not regulations, but rather represent issues that the Center for Biologics Evaluation and Research (CBER) staff believes should be considered at this time.

You can submit online or written comments on any guidance at any time (see 21 CFR 10.115(g)(5))

If unable to submit comments online, please mail written comments to:

Dockets ManagementFood and Drug Administration5630 Fishers Lane, Rm 1061Rockville, MD 20852

All written comments should be identified with this document's docket number: FDA-2009-D-0132-0016.

04/21/2021

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Guidance for Human Somatic Cell Therapy and Gene Therapy | FDA

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Complete responses reported for Nkarta’s off-the-shelf NK cell therapies – Clinical Trials Arena

Posted: May 2, 2022 at 2:40 am

On April 25, Nkarta, a biopharmaceutical company developing off-the-shelf engineered natural killer (NK) cell therapies, announced highly promising results from two Phase I trials. The trials were investigating Nkartas two lead chimeric antigen receptor (CAR) NK cell therapy candidates, NKX101 and NKX019.

In the first trial, NKX101, which is engineered to target the NKG2D ligand on cancer cells, was administered to 21 patients, 17 with relapsed/refractory acute myeloid leukaemia (AML), and four with myelodysplastic syndrome (MDS). Three of the five patients with heavily pretreated AML, who received the three-dose regimen of 1-1.5 billion cells, achieved a complete response (CR), with two of these responses being minimal residual disease negative, a good predictor for a durable response. Neither of the two MDS patients who received this dose level had any response. There were responses in AML patients treated with lower dosing regimens; however, no complete responses were reported. The overall response rate (ORR) for AML patients across dosing levels was 47%.

In the second trial, NKX019, which is engineered to target the B-cell antigen CD19, was administered to ten patients with heavily pretreated non-Hodgkin lymphoma (NHL), and three patients with relapsed/refractory B-cell acute lymphoblastic leukaemia (B-ALL). Three of the six NHL patients who received three doses of 1 billion cells achieved a CR, and the ORR was 83%. The ORR across dosing levels for NHL patients was 70%. No responses were reported in the three patients with B-ALL.

CAR T-cells are the first class of engineered immune cells to have received regulatory approval. CAR T-cell therapies, both marketed and in development for the treatment of haematological malignancies, have demonstrated very impressive response rates. While this class of therapeutics has provided a cure for some patients, significant challenges of utilising CAR T-cells remain. The toxicities associated with CAR T-cell treatment are serious and sometimes fatal, including cytokine release syndrome, graft-versus-host disease (GvHD) and neurotoxicity. The cost associated with CAR T-cell treatment is also significant, with the expansion and engineering of autologous cells required for each patient. The autologous nature of these products also means that it takes several weeks from T-cell collection until the product is ready for infusion, with this delay increasing the risk of disease progression. The drawbacks associated with CAR T-cells have driven the development of CAR NK-cells, with no dose-limiting toxicities reported for either NKX101 or NKX019. No cases of cytokine release syndrome, neurotoxicity or GvHD occurred in either trial. With no human leukocyte antigen (HLA)-matching restrictions, CAR-NK therapies can be off-the-shelf products, reducing the cost of therapy and enabling rapid treatment initiation.

The findings reported by Nkarta demonstrate the potential of this novel therapy class. However, it remains to be seen whether the responses are durable and provide curative treatment, as has been observed with CAR T-cell therapies. Nkarta will face competition from other biotech companies developing CAR-NK cells, including Fate Therapeutics, Affimed and Asclepius Technology. Breakthroughs in the development of allogeneic CAR T-cells mean that off-the-shelf CAR T therapies with reduced toxicity may also enter this treatment landscape.

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Enrollment Low for Black Patients With Hematologic Malignancies On Trials Supporting FDA Approvals of CAR T-Cell Therapy – Cancer Network

Posted: May 2, 2022 at 2:40 am

Investigators observed low enrollment of Black patients on CAR T-cell therapy clinical trials that supported FDA decisions in hematologic malignancies, especially in multiple myeloma.

Enrollment on CAR T-cell clinical trials supporting FDA approvals was notably low among Black patients with hematologic cancers, especially those with multiple myeloma, according to a findings from a study presented at the 2022 Tandem Meeting.

Investigators noted that efficacy data were reported for 74% of the 1051 patients who enrolled on a clinical trial and received treatment with a CAR T-cell therapy. Of the 782 patients who were treated in the trials, only 28 (3.6%) were Black.

As the participation of Black patients in clinical trials that support CAR T-cell therapies has not been well described, investigators launched an analysis to assess and identify any relevant disparities. FDA approvals examined in the analysis took place from August 3, 2017, to March 26, 2021. Almost all patients (96%) who enrolled resided within the United States.

The analysis included 7 clinical trials that led to the approval of several CAR T-cell therapies across different indications:

Investigators calculated the prevalence-corrected estimates for enrollment of Black patients by dividing the percentage of Black patients within a clinical trial population by the percent of Black patients in the disease population.

The most common disease types represented include diffuse large B-cell lymphoma (DLBCL; 58%) and multiple myeloma (16%). Of the 7 studies included in the analysis, 2 did not report racial or ethnic information. Of the overall trial populations, 4% of patients with DLBCL, 6% of patients with multiple myeloma, and 1% of patients in other indications were Black. After adjusting for disease prevalence, investigators reported that participation to prevalence ratio was 0.2 for multiple myeloma, 0.4 for mantle cell lymphoma, 0.6 for DLBCL, and 0.8 in follicular lymphoma.

Al Hadid S, Schinke C, Thanendrarajan S, et al. Enrollment of Black Americans in pivotal clinical trials supporting Food and Drug Administration (FDA) chimeric antigen receptor (CAR)-T cell therapy approval in hematological malignancies. Presented at: 2022 Tandem Meeting; April 23-26, 2022; Salt Lake City, UT. Abstract 248.

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Enrollment Low for Black Patients With Hematologic Malignancies On Trials Supporting FDA Approvals of CAR T-Cell Therapy - Cancer Network

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