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Ontario has seen a staggering and deadly drop in HPV vaccinations. We must protect youth against cancer now – Toronto Star

Posted: May 2, 2022 at 2:04 am

Ontarians responded to public health appeals to get vaccinated against COVID-19. Yet, we are moving in the wrong direction when it comes to HPV vaccinations, which protect against nine types of HPV strains and decrease the risk of six types of cancer, including cervical, anal, head and neck.

This must end, with the recognition Ontario is on the brink of an HPV crisis due to this drastic immunization drop.

Vaccines against HPV and the cancers that can follow are a miracle of preventative medicine. The facts are compelling. According to the World Health Organization, if we achieve an HPV vaccination rate of over 90 per cent by 2025, together with screening and treatment, we could eliminate cervical cancer diagnoses by 2040.

Currently, Grade 7 students in Ontario can receive the HPV9 vaccine through the school-based immunization program.

About 60 per cent of 12-year-olds were immunized in 2018-19. Alarmingly, this rate dropped to 0.8 per cent in 2020-21.

This drop will have a long-lasting impact. One American study predicts missed vaccinations in 2020 could lead to thousands of additional cases of cervical cancer over the next 100 years, with incidence continuing to increase until the 2050s.

The decline comes as no mystery. From March 2020 to January 2022, Ontario schools were closed for more than 27 weeks along with school-based immunization programs. Public health and school boards were forced to concentrate on COVID-19, leaving HPV vaccination campaigns behind

That sense of priority must be re-established to ensure prompt vaccination against HPV for half a million 12-to-15-year-olds.

First, we need to ensure access to vaccinations. School-led vaccination clinics in middle schools remain our most effective way to reach unvaccinated populations. We also need to include high school programs to reach those that missed their opportunity to get vaccinated during school closures.

Second, pharmacists should be empowered to provide HPV vaccinations. Paired with mobile vaccination sites and public health clinics, a collaborative model minimizes barriers to access.

Third, education about cancer prevention through HPV vaccination must be boosted, as families often fail to make the connection. Health-care professionals play a huge role in helping parents understand these risks, and make vaccination an available option by working with their local public health unit to order doses for eligible patients.

Finally, its crucial to emphasize the benefits of vaccination. HPV vaccination is almost 100 per cent effective against cervical cancer if a complete regimen is given before age 25.

We know HPV vaccines are safe. Evidence from programs that have delivered over 270 million doses of HPV vaccines show no serious side effects.

Its time to urge the government, public health, school boards and primary care providers to work together to fill this massive gap.

No one wants to hear the words, you have cancer. And no one wants to learn something as simple as getting vaccinated could have prevented the outcome. When it comes to HPV vaccinations among youth, we must act now.

Dr. Vivien Brown is a family physician, HPV prevention expert and chair of the Federation of Medical Women of Canada (FMWC) HPV Immunization Task Force.

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These experts think this is the future of deep tech in Utah – Utah Business – Utah Business

Posted: May 2, 2022 at 2:04 am

In March 2022, Utah Business and Altitude Labs hosted a half-day summit focused on the ins and outs of the Deep Tech industry. Moderated by Jack Boren, managing director of Epic Ventures watch the entire first panel above or read the printed recap below.

Laura Pace | Founder and CEO | Metrodora |

To me, deep tech is really leveraging the power of technology to solve hard problems. Biology is a series of really hard problems, its incredibly complex, its interconnected, and so its a systems biology problem that actually the human brain cant solve on its own. And so [at Metrodora] we have to implement technological tools to be able to help us understand biology better and in doing so, were going to be able to understand medicine better.

Mandy Rogers | System Engineering Director | Northrop Grumman

To build off of that a little bit, I like to think of deep tech as really the platform of being able to innovate and create where we previously couldnt. Theres high technology risk, but now were at a point in the ecosystem of technology and engineering where we can do things that werent possible 5, 10, or 20 years ago.

Linda Cabrales | Director | Utah Innovation Center

When I think of deep tech, you can think of what its not. So its not like if youre developing an app, thats quick usually if you know what youre doing, but when you think of the things that are based on science and engineering, that is where youre finding difficult things, and youre finding those technologies that can help respond to those.

Mandy Rogers | System Engineering Director | Northrop Grumman

This is probably one of my favorite topics. I look for high-energy collaborators who have some technical experience or diversity of thought. I have engineers on my team who have worked in the cyber domain. Ive had aerospace engineers, Ive had electrical engineers, just any kind of engineer you can think of, and non-engineer, we actually have someone who came from business management who works with a lot of numbers and data, and theyre all helping us solve some really complex technical challenges. So I really look to build those super-diverse teams that have that motivation and want to solve hard problems together, and thats worked really well.

Angela Trego | Director of Science and Technology | UAMMI

I know this is maybe another topic, but kind of along those same lines [of having good talent with diverse thinking], one of the things that weve taken initiative for is actually finding ways to educate and increase that STEM pipeline. Because at the end of the day, we need to get more people into this state that can actually be qualified to be working in these higher paying and really cool deep tech jobs.

Angela Trego | Director of Science and Technology | UAMMI

One of the things that I find encouraging in biotech, if you look at a diversity statistic, its now about 50/50 men to women, which is pretty exciting. Now you go to mechanical engineering and its about 11 percent. You go to computer science, its about 8 percent women.

To me [success from a hiring and diversity standpoint is about] getting kids and showing them what possibilities they have, that they can work in deep tech thats going to have these huge magnificent changes on how we live and work with faculty members.

Linda Cabrales | Director | Utah Innovation Center

I think a trend in healthcare that were seeing is the estimates that 50 percent of people will actually change jobs in the next few years. And this is actually very different than what weve seen historically. But I think its because people really want to be a part of something bigger. They want to be a part of change. They want to be a part of something that means something that has a true impact.

Mandy Rogers | System Engineering Director | Northrop Grumman

We are definitely in an interesting time for talent recruitment and retention, and we are a very large company. We really have to lead with heart and with just empathy, and were seeing now that people are a bit more risk-averse of switching jobs, switching careers, switching needs, and doing something that they hadnt done before in their career.

People have lived through a pandemic, so its kind of like, hey, why not? Maybe I can become a rocket scientist too. Whats the worst that could happen? Were seeing that shift and I think it opens up the door to a lot more diversity of again, building off of deep tech, what can we do next? If we bring someone is not a rocket scientist in the rocket science field and have them think about these hard problems.

Linda Cabrales | Director | Utah Innovation Center

I think its so amazing now when I think of everything going on, the many opportunities, the Women Tech Council, many of you may know about that. They do a She Tech Explorer day, and so they invite these young girls to come to this day they have mentors and they give them a scientific challenge. There are so many opportunities, and I love the idea that we can mentor these young people and encourage them that anything is possible.

Angela Trego | Director of Science and Technology | UAMMI

I think its important, especially women tend to, although all individuals, as they get to certain levels, but it does happen more to women and underrepresented populations, imposter syndrome. And one of the biggest things [needed] to overcome imposter syndrome is having a mentor.

Mandy Rogers | System Engineering Director | Northrop Grumman

You talked about imposter syndrome. I once had a young male mentee tell me, I think you have imposter syndrome. I became kind of obsessed with researching about it. And I was like, yeah, you know what? I could do this. Its not that hard. Everyones learning even these SMEs that have 30 years of experience, theyre learning along the way too. And it took a lot of time and just reflecting on imposter syndrome that a mentee shared with me and exposed me to, to build up the confidence in myself and actually be able to execute.

Laura Pace | Founder and CEO | Metrodora

When we were thinking about where we wanted to locate Metrodora, the science piece [of Utahs tech community] was really integral for us. The other thing has been the collaboration, the openness, the fact that we can meet with someone so easily from the governors office, whos willing to help us with questions that we have, this doesnt happen in other places as easily. And theres just a great community here. I find that people, again, want to be part of teams, part of something. So theyre super motivated. Its just a wonderful place to live and to work.

Laura Pace | Founder and CEO | Metrodora

Were in the era now where [people can sequence their own genomes] for hundreds of dollars, so we can change the [preventative medicine] landscape for people. We can get everyone sequenced before they become ill, so we can start to practice truly personalized medicine, preventative medicine, and prescriptive medicine. This is the thing that Im just so excited about. And this is technology really bringing medicine to sort of the leading edge of science.

Angela Trego | Director of Science and Technology | UAMMI:

From our perspective, one of the biggest factors is going to be batteries. As youre looking at batteries, vehicles, whether theyre cars, flying cars, drones, delivery systems, batteries are complex and difficult. And right now we have issues that theres a capacitythey dont last long enough, they weigh a ton, they have a ton of rare earth metals. Those batteries are really, really toxic. So how do we deal with the toxicity and reusability and recycling of batteries so that theyre not going to be so bad on the environment when were done with them?

Mandy Rogers | System Engineering Director | Northrop Grumman

At Northrop, were building aircraft, spacecraft, and we have to be able to digitize that information very quickly to develop that rapid technology, to explore space, to explore land, air, everything in between. And I think were really going to revolutionize how we do digital threading, digital replication, and digital building blocks to these complex solutions that you can visual as the problem at hand and see things that you couldnt see when its built. From my perspective, its just those more complex systems that are going to get even more complex. And we need to reduce that cognitive burden on folks like our rocket scientists so they can solve the next harder problem.

Linda Cabrales | Director | Utah Innovation Center

Im just amazed at all the technologies that are being developed. And when I look ahead from simulation to medical advances, there are so many amazing things and we get to understand or see so much of that. When I think of medical advances, it gets personal to me, and its so amazing when I think of the future of everyone, right? And we all want to be healthy. We want a better climate. We want better technologies, and thats what Im about.

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Ouras new CEO discusses the future of the smart ring – TechCrunch

Posted: May 2, 2022 at 2:04 am

Tom Hale gestures as speaks, revealing an Apple Watch on one arm and an Oura Ring on the other. When I point out the combination, he takes a beat. I think it varies based on the use case and why you come to Ring, the executive answers. One of my first questions of the company was, how many of the Ring wearers have the Apple Watch? And the number was surprising high.

Oura puts the figure at around 30% or just under a third. Its a surprising figure at first blush, running counter to the notion of the Oura Ring as solely a standalone activity tracker. Thats how I had initially contextualized the product, as something akin to a wrist-worn fitness device in a smaller, less intrusive form factor.

Theres often a stark contrast between the expectation and realities of user adoption. You really dont know how the world is going to interact with your product until your product is out in the world. Oura is far from the first health-focused wearable heck, its not even the first health-focused ring. It has, however, bucked expectation in a number of ways.

In an overcrowded market dominated by smartwatches (and, really, one specific brand), Oura managed to carve out its own niche. A little over a month ago, the firm announced that it had sold its one millionth ring. Its an impressive figure for a relatively new product in an unproven form factor. Much of the companys successes have come from leaning into health studies as well as partnerships with big-name sports leagues, from the NBA to NASCAR.

Much of this impressive growth happened under the purview of Harpreet Singh Rai. A former Wall Street hedge manager, Singh Rai became a true believer in the product, citing his own weight loss journey. He became an investor and board member before stepping into the top spot in 2018. After a three-year run, he announced his exist via LinkedIn late last year.

Rattling off some key milestones for the company, Singh Rai added, While all those accomplishments are great, Ive come to realize thats not the point. I remember talking to another CEO that I admire and he once described the point of any company is really to endure, and by that, for an idea to live in the world forever, beyond anyone of us.

Image Credits: Brian Heater

COO Michael Chapp stepped into the interim role before Hale was announced earlier this week. The new CEO brings experience from a wide range of roles at companies, including Adobe, HomeAway, Momentive AI and Second Life producer, Linden Labs. As Oura pushes more deeply into data collection and app-based actionable insights, software has increasingly become a focus for the firm. But at its heart, its still a hardware company something that has, thus far, been absent from his resume.

Hardware is hard, and it also requires discipline, says Hale. It requires a rigor, which is powerful, particularly if youre trying to do something difficult. The ambition of this company is broad, big and bold. Were trying to put people in charge of their health and give them data and insights to make better choices and maybe their healthcare over time. Thats a huge mission. Hardware is an enabler of that and software is the key. Data science is the key. Personalization is the key. Thats the opportunity that a person like me who comes from a software background can bring.

The companys evolution has not come without growing pains. In particular, a shift toward a subscription service rubbed some of Ouras fanbase the wrong way. The company has promised deeper insights by way of its app, while moving some existing offerings behind a paywall effectively asking users to pay a monthly fee for some of the data that had previously been included as part of the hardwares upfront $300 cost. Hale says it was an issue he focused on after being asked to join the company.

Image Credits: Brian Heater

There is a clear value of ongoing continuous data and continuous investment, he says. In order to continue doing that and supporting the science that underlies it and expanding it to new adjacencies outside of sleep, I think theres a cause for a subscription business model. Unfortunately, most people who buy wearables pay the price and want the things it does now. I think that was a miscalculation on the part of the company. The only thing I think we can do to make it different and better is to deliver the things we said we would have be a part of the gen-three lifecycle.

Hale points to exempting earlier Oura Ring adopters, as well as the warning the company gave users ahead of the third-generation ring launch. He also notes that moving to a lower upfront cost and a hardware-as-a-service approach are models that are likely in the companys future. He cites reports around Apple and Pelotons explorations in the space as evidence of HaaS becoming more accepted by the mainstream.

An IPO could certainly be in Ouras future, as well, under Hales watch. Though he cautions that such a move is probably still a ways away.

The markets have been pretty choppy of late, and I think Ive got some work to do to get there. I dont think were building this company to IPO. Were not building this company to IPO, were building this company to make an impact on the world of health and put preventative medicine into the hands of people who can improve their lives with it.

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Nanox Announces FDA Clearance for HealthOST Device, an AI Software Measuring Vertebral Compression Fractures and Low Bone Density, Which are Often…

Posted: May 2, 2022 at 2:04 am

NEVE ILAN, Israel--(BUSINESS WIRE)--NANO-X IMAGING LTD ("Nanox" or the "Company," Nasdaq: NNOX), an innovative medical imaging technology company, today announced that its deep-learning medical imaging analytics subsidiary, Nanox.AI, received FDA 510(k) clearance for HealthOST device, an AI software that provides qualitative and quantitative analysis of the spine from CT to support clinicians in the evaluation and assessment of musculoskeletal disease. Measurements of vertebral fractures and low bone density have been shown to increase the identification of patients with musculoskeletal disease of the spine, such as osteoporosis, a disease that affects more than 10 million people in the U.S.1

This is Nanox.AIs tenth FDA clearance across its innovative portfolio of AI clinical decision assist tools and second FDA clearance for its vertebral compression fracture device. HealthOST offers a more detailed evaluation, including the ability to measure fractures more precisely, potentially aiding clinicians in evaluating risk factors for osteoporosis. The companys latest AI solution automatically identifies findings suggestive of compression fractures and low bone density, enabling further work up and treatment of patients diagnosed with osteoporosis to prevent potentially life-changing major osteoporotic fractures, such as a hip fracture. Nanox.AI previously received FDA clearance in May 2020 for the AI software that identifies vertebral compression fractures.

With the FDA clearance of HealthOST, we are thrilled to offer radiologists a new tool that provides deeper analysis of medical images to support identifying those patients who may be at-risk of developing prevalent musculoskeletal conditions such as osteoporosis, to help promote further work up and treatment of those patients, said Pini Ben Elazar, General Manager of Nanox.AI. Our new product reflects our vision to create solutions to improve population health, building upon our strong track record of developing AI applications to help identify risk factors for chronic health conditions.

According to the World Congress of Osteoporosis, 75% of compression fractures are missed or not reported. According to the CDC, approximately 10.2 million adults in the U.S. have osteoporosis while 43.3 million more have low bone density.1 Evidence suggests that there is a 25% mortality rate reported within one year of a patient sustaining a hip fracture.2

This FDA clearance is yet another step in our commitment to delivering technologies that promote population health and value-based care, said Erez Meltzer, Chief Executive Officer of Nanox. AI technologies like HealthOST are poised to support routine clinical decision making and potentially improve patients health outcomes.

HealthOST provides qualitative and quantitative analysis of the spine, including labelling of T1-L4 vertebrae, measurement of height loss in each vertebra (T1-L4) and measurement of the mean Hounsfield Units (HU) in volume of interest within vertebra (T11-L4). HealthOST is indicated for use in patients aged 50 and over undergoing CT scan for any clinical indication that includes at least four vertebrae in the T1-L4 portion of the spine (for vertebral height loss) and T11-L4 (for bone attenuation) portions of the spine.

Nanox.AIs portfolio also includes HealthCCSng, an FDA-cleared AI cardiac imaging solution that quantifies coronary artery calcium (CAC), to identify patients potentially at risk for a cardiovascular event, to promote further work up and possible treatment for cardiac disease.

About Nanox

Nanox (NASDAQ: NNOX) is focused on applying its proprietary medical imaging technology and solutions to make diagnostic medicine more accessible and affordable across the globe. The vision of Nanox is to increase the early detection of medical conditions that are discoverable by medical image technologies based on X-rays, which we believe is key to increasing early prevention and treatment, improving health outcomes, and, ultimately, saving lives. We are developing a holistic imaging solution, which includes the Nanox System, comprised of the Nanox.ARC using our novel MEMs X-ray source technology, and the Nanox.CLOUD, a companion cloud software, integrated with AI solutions and teleradiology services. Our vision is to increase early detection of medical conditions that are discoverable by X-ray by improving access to imaging, reducing imaging costs, and enhancing imaging efficiency, which we believe is key to increasing early prevention treatment, improving health outcomes and ultimately saving lives. For more information, please visit http://www.nanox.vision.

About Nanox.AI

Nanox.AI is the deep-learning medical imaging analytics subsidiary of Nanox. Nanox.AI solutions are developed to target highly prevalent chronic and acute diseases affecting large populations around the world. Leveraging AI, Nanox.AI helps clinicians extract valuable and actionable clinical insights from medical imaging that otherwise may go unnoticed, potentially initiating further medical assessment to establish individual preventative care pathways for patients. For more information, please visit http://www.nanox.vision/ai.

Forward-Looking Statements

This press release may contain forward-looking statements that are subject to risks and uncertainties. All statements that are not historical facts contained in this press release are forward-looking statements. Such statements include, but are not limited to, any statements relating to the initiation, timing, progress and results of the Company's research and development, manufacturing and commercialization activities with respect to its X-ray source technology and the Nanox.ARC, the ability to realize the expected benefits of the acquisitions, and the projected business prospects of the Company and the acquired companies. In some cases, you can identify forward-looking statements by terminology such as can, might, believe, may, estimate, continue, anticipate, intend, should, plan, should, could, expect, predict, potential, or the negative of these terms or other similar expressions. Forward-looking statements are based on information the Company has when those statements are made or management's good faith belief as of that time with respect to future events, and are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in or suggested by the forward-looking statements. Factors that could cause actual results to differ materially from those currently anticipated include: risks related to (1) the inability to successfully integrate the acquired companies business, (2) the inability to realize the anticipated benefits of the acquisitions, which may be affected by, among other things, competition, brand recognition, the ability of the acquired companies to grow and manage growth profitably and retain their key employees, (3) costs related to the acquisitions and/or unknown or inestimable liabilities, (4) changes in applicable laws or regulations that impact the operations of the acquired companies, (5) the failure to meet projected technology development targets, (6) the failure of the acquired companies to effectively scale end-to-end medical imaging solutions worldwide, (7) changes in global, political, economic, business, competitive, market and regulatory forces, and (8) (i) Nanoxs ability to successfully demonstrate the feasibility of its technology for commercial applications; (ii) Nanoxs expectations regarding collaborations with third-parties and their potential benefits; and (iii) Nanox's ability to conduct business globally, among other things.

For a discussion of other risks and uncertainties, and other important factors, any of which could cause Nanoxs actual results to differ from those contained in the Forward-Looking Statements, see the section titled Risk Factors in Nanoxs Annual Report on Form 20-F for the year ended December 31, 2020 and subsequent filings with the U.S. Securities and Exchange Commission. The reader should not place undue reliance on any forward-looking statements included in this press release.

Except as required by law, Nanox undertakes no obligation to update publicly any forward-looking statements after the date of this report to conform these statements to actual results or to changes in the Company's expectations.

______________________________1 Osteoporosis or Low Bone Mass in Older Adults: United States, 20172018. Centers for Disease Control and Prevention. Updated March 31, 2021. Accessed April 26, 2022. https://www.cdc.gov/nchs/products/databriefs/db405.htm 2 Schnell S, Friedman SM, Mendelson DA, Bingham KW, Kates SL. The 1-year mortality of patients treated in a hip fracture program for elders. Geriatr Orthop Surg Rehabil. 2010;1(1):6-14. doi:10.1177/2151458510378105

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The work-from-home culture is slowing progress in the fight against prostate cancer – MedCity News

Posted: May 2, 2022 at 2:04 am

Corporate wellness programs over the past two decades have grown to be an effective and efficient solution to help millions of employees. Benefits leaders at thousands of companies nationwide have been instrumental in promoting healthy behaviors across their organizations, improving access to preventive health services, and increasing utilization of appropriate health screenings. In-person screenings at the officebefore and after work, during lunchtime or during employee breaksbecame commonplace.

That changed when the Covid-19 pandemic shifted work out of the office and into employees homes. The same preventive screenings that were once offered in the workplace now required a trip to the doctor. This had specific consequences for men, a subtle but significant effect of the new work-from-home culture. Studies have shown that men are less likely to use preventive healthcare services than women, and do not seek immediate treatment for many of their unique health problems.

With a reduction in workplace screenings comes a practical consequence. For the employer-managers of self-paid insurance plans, a new worry has emerged: Male employees who are working from home havent had an in-person prostate screening in more than a year. According to Johns Hopkins Medicine, the earlier prostate cancer is caught, the more likely it is for a man to get successful treatment and remain disease-free. Losing a year in the fight against the disease is a potentially significant setback.

Prostate cancer screenings arent the only precautions taking a back seat to Covid-19. According to the American Cancer Society, the pandemic resulted in many elective procedures being put on hold, including a substantial decline in all cancer screenings. Healthcare facilities have provided cancer screenings during the pandemic with many safety precautions in place, but men were reluctant to schedule such exams even before the pandemic began.

Prostate cancer presents a particular threat to men. It primarily afflicts men over the age of 40. Overall its the second-leading cause of cancer death among American men, behind only lung cancer. The ACS projects about 268,490 new cases of prostate cancer and 34,500 deaths in 2022.

Fortunately, prostate cancer is eminently treatable, with an expected five-year survival rate of 98%, according to the ACS. The prostate-specific antigen (PSA) testa take-home blood testis commonly available in lieu of the traditional rectal examination with a doctor. According to the ACS, both the PSA and rectal exams can be used as prostate cancer screening tools.

But there are other compounding factors preventing men from getting screening. In addition to the growing work-from-home trend, 1 in 4 men do not have primary care doctors. Without this essential line of communication, men who need a prostate exam might not learn that they can take a PSA test from the comfort of their home.

This conundrum puts well-meaning executives in a similar place to where they began, when workplace screenings were first introduced. It is widely known that employee health directly affects performance. Think of the many wellness-focused solutions that exist to help an employee in his home office.

Employers have implemented a variety of digital health and telehealth solutions to help their employees manage and reverse chronic diseases. Subscriptions to smartphone apps that promote healthy behaviorCalm, Noom, and othersare often tucked into todays benefit packages. These offer a way around the barrier of the doctors office, and are an excellent way to promote the health of work-from-home employees.

When it comes to prostate health, new solutions are needed as well. Its important for men to have easy access to discrete care. Combined with a telehealth appointment, a PSA exam can reengage men with their prostate health without leaving their home office. Men are unlikely to take initiative to schedule these on their own, so it is wise for employers to take advantage of technology to facilitate at-home screenings.

For men who have undiagnosed prostate cancer, waiting until next years physical exam can be dangerous. Prostate cancers detected at Stage IV have an average five-year survival rate of 28%. Thats why it is essential to promote preventative solutions that meet an entire workforces needs.

Photo: Main_sail, Getty Images

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York University reaches world’s Top 35 in Times Higher Education Impact Rankings – Benzinga – Benzinga

Posted: May 2, 2022 at 2:04 am

Toronto, ON, April 27, 2022 (GLOBE NEWSWIRE) -- York University is strengthening its position as a leader in creating a sustainable and inclusive world, ranking in the world's top 35 in the respected Times Higher Education Impact Rankings.

York U has ranked 33 out of 1,406 post-secondary institutions, moving up 34 spots from its position at 67/1,117 last year.

The impact ranking is influential as the United Nations assesses the performance of universities worldwide in meeting its sustainable development goals.

"Our continued recognition as a world leader in the Times Higher Education Impact Rankings is a testament to York's steadfast commitment to build a more just and sustainable future," said Rhonda Lenton, York's president and vice-chancellor.

"Sustainability is one of the foundations of ourUniversity Academic Plan 20202025: Building a Better Futurethat guides teaching, research and operational activities. I want to thank the entire York community for their extraordinary efforts to work together towards the pursuit of peace and prosperity for people and the planet both locally and globally."

The Times Higher Education Impact Rankingsconsiders factors such as research, stewardship, outreach and teaching to determine the rank for each institution. The UN has 17 global sustainable development goals for 2030, and York is well ranked among the top 100 universities across them. York's focus on sustainability resulted in several top rankings:

Lisa Philipps, provost and vice-president academic, credited the hard work and dedication of students, faculty, staff and alumni for contributions that inspire the entire York community to help build a better future.

"The UN's 17 sustainable development goals represent fundamental values at York," Philipps said. "They align with the six priorities for action that we have set for ourselves within theUniversity Academic Planand reaffirm our longstanding values of social justice, equity and sustainability. This achievement represents the dedication of the entire York community."

These higher education rankings were introduced in 2019 to evaluate universities around the world and assess how they were meeting the sustainable development goals set by the UN.

"York's top-35 ranking recognizes the University's dedication to creating a diverse community that works together to address complex societal challenges and to conduct research and scholarly activity that advances knowledge and creates positive change, said Amir Asif, vice-president research and innovation.

"York conducts purposeful research that is making a difference in our local and global communities," said Asif. "Our researchers are dedicated to solving global challenges that will lead to a more equitable, sustainable and inclusive world."

As it is for York, inclusivity is central to the UN's sustainable development goals. Both organizations seek to break down barriers worldwide.

TheTD Community Engagement Centrestrives for academic innovation through community building, education, and experiential learning for the Black Creek Community, one of the most diverse communities in Toronto.

Women and children from kindergarten to Grade 12 can access programs and services through the Carswell Foundation's ground-breaking partnership between the School of Arts, Media, Performance and Design and the Regent Park School of Music.

TheProvost's Postdoctoral Fellowships for Black and Indigenous Scholarsprovides resources, mentorship and up to $70,000 a year for learners seeking to get a foothold in their career.

Lenton says York takes a collaborative approach to sustainability, bringing people, institutions, cities and countries together to engage as partners.

In the GTA, York has been engaging with the City of Markham as it prepares to open its newMarkham Campuswhere construction is underway, as well as with business and community leaders working to give diverse communities in the region a voice. The Keele Campus is being reimagined, meanwhile, and will include consultation with the communities it serves.

The University and the City of Vaughan have begun looking at how York can play a greater role within the Vaughan Healthcare Centre Precinct, including a newSchool of Medicine. The precinct is a collaboration between York, Vaughan, Mackenzie Health and ventureLAB and will create a centre of excellence for health, preventative medicine and community care.

York's partnerships also create positive change for international communities. The University offers free degree and non-degree education programs and supports for refugees in Sub-Saharan Africa; and bursaries and scholarships to help recent immigrants to Canada gain the skills they need to work and thrive.

Philipps says York is well positioned to continue to meet the UN's inclusivity and sustainability goals.

"We are now digging in even deeper to right the future by committing to meaningful steps, both small and large, toward a more just and sustainable future."

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Aging Brain Initiative awards fund five new ideas to study, fight neurodegeneration – MIT News

Posted: May 2, 2022 at 2:03 am

Neurodegenerative diseases are defined by an increasingly widespread and debilitating death of nervous system cells, but they also share other grim characteristics: Their cause is rarely discernible and they have all eluded cures. To spur fresh, promising approaches and to encourage new experts and expertise to join the field, MITs Aging Brain Initiative (ABI) this month awarded five seed grants after a competition among labs across the Institute.

Founded in 2015 by nine MIT faculty members, the ABI promotes research, symposia, and related activities to advance fundamental insights that can lead to clinical progress against neurodegenerative conditions, such as Alzheimers disease, with an age-related onset. With an emphasis on spurring research at an early stage before it is established enough to earn more traditional funding, the ABI derives support from philanthropic gifts.

Solving the mysteries of how health declines in the aging brain and turning that knowledge into effective tools, treatments, and technologies is of the utmost urgency given the millions of people around the world who suffer with no meaningful treatment options, says ABI director and co-founder Li-Huei Tsai, the Picower Professor of Neuroscience in The Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences. We were very pleased that many groups across MIT were eager to contribute their expertise and creativity to that goal. From here, five teams will be able to begin testing their innovative ideas and the impact they could have.

To address the clinical challenge of accurately assessing cognitive decline during Alzheimers disease progression and healthy aging, a team led by Thomas Heldt, associate professor of electrical and biomedical engineering in the Department of Electrical Engineering and Computer Science (EECS) and the Institute for Medical Engineering and Science, proposes to use artificial intelligence tools to bring diagnostics based on eye movements during cognitive tasks to everyday consumer electronics such as smartphones and tablets. By moving these capabilities to common at-home platforms, the team, which also includes EECS Associate Professor Vivienne Sze, hopes to increase monitoring beyond what can only be intermittently achieved with high-end specialized equipment and dedicated staffing in specialists offices. The team will pilot their technology in a small study at Boston Medical Center in collaboration with neurosurgeon James Holsapple.

Institute Professor Ann Graybiels lab in the Department of Brain and Cognitive Sciences (BCS) and the McGovern Institute for Brain Research will test the hypothesis that mutations on a specific gene may lead to the early emergence of Alzheimers disease (AD) pathology in the striatum. Thats a a brain region crucial for motivation and movement that is directly and severely impacted by other neurodegenerative disorders including Parkinsons and Huntingtons diseases, but that has largely been unstudied in Alzheimers. By editing the mutations into normal and AD-modeling mice, Research Scientist Ayano Matsushima and Graybiel hope to determine whether and how pathology, such as the accumulation of amyloid proteins, may result. Determining that could provide new insight into the progression of disease and introduce a new biomarker in a region that virtually all other studies have overlooked.

Numerous recent studies have highlighted a potential role for immune inflammation in Alzheimers disease. A team led by Gloria Choi, the Mark Hyman Jr. Associate Professor in BCS and The Picower Institute for Learning and Memory, will track one potential source of such activity by determining whether the brains meninges, which envelop the brain, becomes a means for immune cells activated by gut bacteria to circulate near the brain, where they may release signaling molecules that promote Alzheimers pathology. Working in mice, Chois lab will test whether such activity is prone to increase in Alzheimers and whether it contributes to disease.

A collaboration led by Peter Dedon, the Singapore Professor in MITs Department of Biological Engineering, will explore whether Alzheimers pathology is driven by dysregulation of transfer RNAs (tRNAs) and the dozens of natural tRNA modifications in the epitranscriptome, which play a key role in the process by which proteins are assembled based on genetic instructions. With Benjamin Wolozin of Boston University, Sherif Rashad of Tohoku University in Japan, and Thomas Begley of the State University of New York at Albany, Dedon will assess how the tRNA pool and epitranscriptome may differ in Alzheimers model mice and whether genetic instructions mistranslated because of tRNA dysregulation play a role in Alzheimers disease.

With her seed grant, Ritu Raman, the dArbeloff Assistant Professor of Mechanical Engineering, is launching an investigation of possible disruption of intercellular messages in amyotrophic lateral sclerosis (ALS), a terminal condition in which motor neuron causes loss of muscle control. Equipped with a new tool to finely sample interstitial fluid within tissues, Ramans team will be able to monitor and compare cell-cell signaling in models of the junction between nerve and muscle. These models will be engineered from stem cells derived from patients with ALS. By studying biochemical signaling at the junction the lab hopes to discover new targets that could be therapeutically modified.

Major support for the seed grants, which provide each lab with $100,000, came from generous gifts by David Emmes SM 76; Kathleen SM 77, PhD 86 and Miguel Octavio; the Estate of Margaret A. Ridge-Pappis, wife of the late James Pappis ScD 59; the Marc Haas Foundation; and the family of former MIT President Paul Gray 54, SM 55, ScD 60, with additional funding from many annual fund donors to the Aging Brain Initiative Fund.

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Treadwell Therapeutics Announces Fast Track Designation Granted by the FDA to CFI-400945 for the Treatment of Acute Myeloid Leukemia – PR Newswire

Posted: May 2, 2022 at 2:03 am

NEW YORK and HONG KONG, April 26, 2022 /PRNewswire/ --Treadwell Therapeutics, a clinical-stage biotechnology company developing novel medicines for unmet needs in cancer, announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to CFI-400945, a first in class inhibitor of Polo-like kinase 4 (PLK4), for the treatment of adult patients with relapsed or refractory Acute Myeloid Leukemia (AML).

"Although several exciting new classes of medicines have emerged in the past decade for patients with AML, there still remains an unmet need for certain patient segments, where survival rates remain low," said Dr. Michael Tusche, Treadwell co-CEO. "CFI-400945, has shown encouraging signs of monotherapy activity in AML patients with adverse cytogenetics. We are grateful for the Fast Track Designation for this exciting program, and look forward to frequent interactions with the FDA to chart our regulatory path forward, as we continue the development of '945 in leukemia."

Fast Track designation seeks to streamline the development and accelerate the review of new agents with potential to treat serious or life-threatening diseases and that potentially address an unmet medical need. Drugs that are granted this designation can have more frequent interactions with the FDA, as well as potential pathways for expedited approval.

About AML

AML is a disease characterized by uncontrolled proliferation of malignant clonal hematopoietic stem cells which can lead to anemia, neutropenia, and thrombocytopenia. If left untreated, AML can lead to death within weeks. In the US, an estimated 19,940 new cases of AML were expected to be diagnosed and approximately 11,180 deaths attributed to AML, nearly all in adults. AML is generally a disease of the elderly with an average age of 68 years at the time of diagnosis and is more common in men than women. For adults <65 years of age, the 5-year survival is approximately 33%, but drops dramatically to 4% in adults >65 years of age.

About Treadwell TherapeuticsTreadwell Therapeutics is a clinical-stage multi-modality oncology company developing novel medicines to address unmet needs in patients with cancer. The Company's robust, internally developed clinical pipeline includes CFI-400945, CFI-402257 (TTK inhibitor) and CFI-402411 (HPK1 inhibitor). Treadwell also has a robust pre-clinical pipeline with multiple biologic and next generation TCR based autologous cell therapy programs. For more information, please visit http://www.treadwelltx.com.

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What’s Trending in the World of Hair Treatments – NewBeauty Magazine

Posted: May 2, 2022 at 2:03 am

A good hair day can bolster your confidence or, conversely, leave you feeling less than your best. Its no surprise interest for professional hair services is rising yet again, according to Spate research: Searches for hair salons are growing by almost 12 percent since last year and there are 4.2 million inquiries for hair services on an average monthly basis.

But the hunt is over. Whether youre shopping for a dye-coated life change, need some inspiration before your next salon visit or are considering investing in your hairs health once and for all, heres whats trending now in the world of transformative hair treatments.

It may be among the most straightforward ways to transform your hair, but the power of a cut and color should not be discounted. Your haircut and color is a frame to your personal image, says R+Co Collective member and colorist Richy Kandasamy. Transforming your hair can be a whole life-changing moment. As showcased in Kandasamys clients dramatic transformation, sharp angles and show-stopping cuts are currently trending. (Pinterest searches for mullet hairstyles have increased 190 percent and inquiries for shaved head dye designs are up 12x since last year.)

Before coloring Ashleys hair, we started with the undercut to help visualize the end result. After assessing her style, personality, complexion and eye level, we were able to choose the perfect color, says Kandasamy. He then pre-lightened her hair using a powder lightener, then toned with a demi-permanent haze blonde color.

Pantones color of the year may be lilac-hued Veri Peri, but when it comes to hair, 2022 is all about brunette tones, natural-looking dimension and 70s blondes. Celebrity colorist Chad Kenyon is known for his lived-in color jobs, and says even subtle changes make a huge impact to those in his chair. Ive had clients cry tears of joy by seeing how hair color has changed the way they see themselves, he says. Kenyon explains he paints hair in such a way that he is able to carefully enhance and diffuse facial features.

Kenyon enhanced this clients auburn hair by adding dimension and faceframing highlights with a natural, lived-in blonde color.

Not ready for a color change or dramatic cut? Adding length and volume to your hair with professional- grade extensions can be just as transformative. Our stylists address our clients hair challenges and identify ways that our extensions can be a tool used to help fix the challenge, says Jennifer Martin, director of marketing for Great Lengths.

I have worn Great Lengths bonded extensions for over 15 years and its given me the confidence I needed to walk through the world as a business woman without worrying about my hair, says this client styled by Marie Green of Hair Extensions by Marie. Its as easy as getting cosmetic filler and it takes my fine, limp hair to a level of confident, powerful and celebrity- worthy locks in one application.

Green applied 18-inch premium keratin-bonded strands from Great Lengths in a variety of colors for a seamless blend.

Because many keratin treatments contain formaldehyde or formaldehyde-releasing chemicalsbe sure to ask your stylist for the specifics on your formula if youre a keratin- userlong-term use of the in-salon treatment can wreak havoc on your strands and leave you with dry, brittle and severely damaged hair over time.

Lorraine Massey of Spiral XYZ salon has made nursing clients hair back to health her mission. My goal is to help clients who have had their hair damaged after years of chemical treatments, she says. Her focus while bringing curl patterns back to life: education, patience and hydration. Once you care for the hair you have and start seeing the health and growth evidence, there is no going back.

Scheduled touch-ups and bleach jobs can do a number on once strong, resilient strands.

Olaplexs latest in-salon innovation, the 4-in-1 Moisture Mask, penetrates the hair shaft to repair damaged, broken bonds after a chemical service. The highly concentrated mask includes elevated levels of ceramides, oils and amino acids to add shine, tame unruly strands and deliver intense moisture to dry hair in need of TLC.

The collagen-rejuvenating power of microneedling with platelet-rich plasma can deliver transformative results when used on the scalp. So much so, Wayne, NJ facial plastic surgeon Jeffrey B. Wise, MD likens the treatment to fertilizer for hair. Microneedling with PRP stimulates the stem cells in the hair root, awakening the scalp and pushing any dormant follicles into growth mode, explains Dr. Wise. We are waking up the hair and giving it the nourishment it needs to start thriving again. PRP is an excellent preventative option for those noticing hair thinning, or anyone with a family history of hair loss over time. However, Dr. Wise notes PRP cannot grow hair in areas where follicles no longer exist, so someone experiencing advanced balding will more likely be a candidate for a hair transplant.

Glenn Dale, MD dermatologist Valerie Callender, MD says in-office hair-loss treatments like microneedling with PRP are often used in combination with nutraceuticals such as Nutrafol or Viviscal to usher in optimal results.

To jump-start growth, its best to target follicles during each of the three hair growth and shedding phases. This requires three sessions of PRP therapy, spaced four to six weeks apart, says Dr. Wise. In the best case scenario, patients would also keep up with maintenance sessions every six months to ensure hair stays healthy.

This 61 year old female complained of hair thinning on her scalp for several years. Along with taking Viviscal Professional Hair Vitamins, Dr. Callender performed three sessions of PRP injections spaced four weeks apart.

The Fotona laser is an ablative skin-resurfacing laser commonly used to achieve a brighter, smoother complexion. It can also be used for skin-tightening and off-the-face plumping. Used off label, New York dermatologist Doris Day, MD has found huge success in the laser beams ability to significantly revive hair follicles on the scalp.

Dr. Day says the laser works through a mechanism of photobiomodulation, where heat and energy are used to stimulate and revive stem cells of the follicle, as well as to stabilize the follicle itself. The Fotona laser can be used to treat many different forms of hair lossDr. Day notes she has seen success in both autoimmune and genetic casesand 12 treatment sessions spaced two weeks apart, are generally recommended, followed by maintenance treatments at three months.

Dr. Day performed multiple treatments of Fotona Hairlase in order to address this 54 year old females hair-loss concerns.

The only permanent solution to hair loss, hair restoration surgery (also known as a hair transplant) involves taking a viable hair graft or follicle from one part of the body and placing it in a different part, most commonly the scalp, says Delray Beach, FL facial plastic surgeon Miguel Mascar, MD.

There are two methods of extracting the grafts: FUT, or strip technique, and FUE, or follicular unit extraction technique, where the grafts are removed one by one. Dr. Wise says most patients prefer the FUE technique as its the least invasive and doesnt leave a linear scar. The best part is the natural-looking result: The transplanted hair will continue growing as if it has always been there, he says.

Candidacy relies on the location and nature of hair loss, but the best candidates for the surgery are those that have a good donor area, and have realistic expectations based on their goals and desires, says Dr. Mascar.

This 29-year-old patient opted for a FUE hair transplant with Dr. Wise. 2,500 grafts were transplanted to the top and sides of her scalp. Results shown at the six-month post-op mark.

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Demand in the US Animal Model Market is set to Increase at a 4.1% CAGR from 2022 to 2032 – Future Market Insights – PR Newswire

Posted: May 2, 2022 at 2:03 am

Companies Profiled in U.S. Animal Model Market are Charles River Laboratories, The Jackson Laboratory, Taconic Biosciences, Inc., Genoway, Envigo (Inotiv, Inc.), Marshall BioResources, Janvier Labs, Applied stem cells, Biocytogen, Transposagen Biopharmaceuticals, Inc. (Hera Bio Labs), Cyagen, Ingenious targeting labs, Crown Bioscience Inc. (JSR Corporation)., Harbour Biomed, Sinclair Bio Resources, Alpha Genesis Inc., Creative Animodel, DaVinci Biomedical Research Products, Inc

NEWARK, Del., April 27, 2022 /PRNewswire/ -- As per Future Market Insights' latest industry analysis, the U.S. animal model market was valued at over US$ 921.9 Mn in 2021 and is anticipated to exhibit a CAGR of close to 4.1% over the forecast period (2022-2032).

Animal models are predominantly used to gather information regarding the disease and its prevention, diagnosis, and treatment. They are being used to resolve a wide range of scientific concerns, ranging from basic science to the discovery and evaluation of new vaccines and therapies. Animals are used because of the similarities in biology across most mammals.

Personalized medicine is also known as precision medicine which utilizes data about a specific patient or an individual's genes to plan treatment for a disease. Animal models can play important role in the development of new approaches for personalized medicine. Increasing adoption of personalized medicine will drive sales of animal model in the forthcoming years.

Toxicity testing in animals is done to discover potential side effects from an agent's exposure and to generate dose-response relationships. Animal testing is important for the early detection of the potential risk to humans or as models to study the causes, pathogenesis, progression, and treatment of diseases.

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Organizations and legislations such as the Federal Food, Drug, and Cosmetic Act (FFDCA), Environmental Protection Agency (EPA), Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), and Organization for Economic Co-operation and Development (OECD) determine the testing guidelines for toxicity testing on animals.

Some factors such as the high production volume of chemicals testing in the U.S., increasing generation and utilization of novel GM animal strains in toxicity studies, and the development and attempted validation of several animal tests to screen chemicals for endocrine (hormone)-disrupting activity are expected to drive the growth in the market.

"Growing R&D expenditure in the pharmaceutical & biopharmaceutical industry, increasing applications of animal model for more predictive outcomes, and ongoing innovations in animal models will augment the growth in the market over the forecast period,"says an FMI analyst.

Key Takeaways:

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Market Competition

Key players operating in the U.S. animal model market are expanding their business through partnerships and acquisitions with other companies to improve their global footprint. Following are a few examples of acquisitions:

What Does the Report Cover?

Future Market Insights offers a unique perspective and actionable insights on the animal model market in its latest study, presenting a historical demand assessment of 20172021 and projections for 2022 2032.

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The research study is based on the species (rats, mice, pigs, rabbits, monkeys, dogs, cats, other species), therapeutics- (metabolic diseases, cardiovascular diseases, neurological diseases, and oncology), application (drug discovery/development and basic & applied research) end-user (academic & research institutes, pharmaceutical companies, biotechnology companies, and CROs) and across seven key regions of the world.

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About Future Market Insights (FMI)

Future Market Insights(ESOMAR certified market research organization and a member of Greater New York Chamber of Commerce) provides in-depth insights into governing factors elevating the demand in the market. It discloses opportunities that will favor the market growth in various segments on the basis of Source, Application, Sales Channel and End Use over the next 10-years.

Contact:Future Market Insights Inc.Christiana Corporate, 200 Continental Drive,Suite 401, Newark, Delaware - 19713, USAT: +1-845-579-5705For Sales Enquiries:[emailprotected]Website:https://www.futuremarketinsights.comReport: https://www.futuremarketinsights.com/reports/u-s-animal-model-marketLinkedIn|Twitter|Blogs

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