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NIH Awards Wake Forest University School of Medicine $4 Million Grant to Study Chronic Pain and Opioid Use Disorder – Newswise

Posted: May 2, 2022 at 2:00 am

Newswise WINSTON-SALEM, N.C. April 25, 2022 Between 40% and 60% of patients who have an opioid use disorder (OUD) also experience chronic pain. While both of these conditions have been studied separately, very little research has been done to address the needs of patients who have both.

To fill this gap, researchers at Wake Forest University School of Medicine have been awarded a five-year, $4 million grant through the National Institutes of Health (NIH) Helping End Addiction Long-term (HEAL) Initiative.

With the grant, researchers will create an Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination Center for a network of clinical research centers that includes the University of New Mexico, Yale University, Albert Einstein College of Medicine and the University of Pittsburgh.

Through the Center, the School of Medicine will coordinate and support the network in the development, evaluation and implementation of patient-centered interventions with each research center conducting two to three clinical trials.

Traditionally, treatments for these conditions have been very siloed, said Dr. Meredith C.B. Adams, principal investigator and assistant professor of anesthesiology at Wake Forest University School of Medicine. There are interventions to treat chronic pain. There are interventions for opioid use, misuse or disorder, but what about treatments for people who have both? Our objective is to find effective interventions to make sure were addressing patient pain while also avoiding an escalation of opioid use disorder.

Another key component of the project will be decreasing stigma associated with these conditions, improving health equity and diminishing health disparities through educational development.

Part of addressing this crisis is understanding patient and community needs, Adams said. Many people with co-occurring chronic pain and opioid use disorder do not seek treatment because of the stigma associated with these conditions. We hope to change that.

The NIH HEAL Initiative, which launched in 2018, was created to find scientific solutions to stem the national opioid and pain public health crises.

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From Immune Function and Cognition to Cardiovascular Health and Cancer Prevention – Health Benefits of Tea Revealed by Researchers from Across the…

Posted: May 2, 2022 at 2:00 am

New Findings Behind the Science of Each Sip Released at Sixth International Scientific Symposium on Tea and Human Health

NEW YORK, April 27, 2022 /PRNewswire/ -- Leading nutrition scientists from around the world convened yesterday to present the latest evidence supporting the role of tea in promoting optimal health. With new findings from the international scientific community consistently lending credibility to tea's healthy properties, speakers at the Sixth International Scientific Symposium on Tea and Human Health provided a comprehensive update of recent research on the benefits of tea consumption on human health. As the second most consumed beverage in the world next to water, over 159 million Americans are drinking tea on any given day.

"There is a growing body of research from around the world demonstrating that drinking tea can enhance human health in many ways," said symposium chair, Jeffrey Blumberg, PhD, an active Professor Emeritus in the Friedman School of Nutrition Science and Policy at Tufts University. "True teas which include black, green, white, oolong, and dark can contribute significantly to the promotion of public health. Evidence presented at this symposium reveals results - ranging from suggestive to compelling - about the benefits of tea on cancer, cardiometabolic disease, cognitive performance, and immune function."

The Chemistry in Your CupTea contains flavonoids, naturally occurring compounds that have antioxidant properties. Tea flavonoids provide bioactive compounds that help to neutralize free radicals which may damage elements in the body, such as genetic material and lipids, and contribute to chronic disease. Tea also contains L-theanine, an amino acid that is for the most part, uniquely found in tea.

Tea and Immune Function"Tea may help support your immune system and increase your body's resistance to illnesses," says Dayong Wu, MD, PhD, Nutritional Immunology Laboratory in the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University. "In the event you do become sick, tea can help your body respond to illness in a more efficient way by ridding itself of the infection and may also alleviate its severity when they happen."

In a comprehensive review of the published data on this topic presented at the symposium, Wu concluded that green tea/catechins have been shown to help the host fight against a variety of pathogens by decreasing the pathogen's ability to infect the host and helping the host's immune system spring into action. Green tea/catechins have also been shown to improve autoimmune disorders by promoting self-tolerance, suppressing autoantigen-induced inflammatory attacks, and enhancing tissue repair.

Tea and Cognitive FunctionWhen it comes to cognitive function, it turns out tea may offer significant benefits. "There is strong evidence that tea and its constituents seem to be beneficial under conditions of stress. The most profound cognitive domain that tea seems to act upon is attention and alertness," explains Louise Dye, PhD, Professor of Nutrition and Behaviour at the University of Leeds. "With these effects on attention, tea is an optimal beverage of choice during a time of elevated stress and burnout worldwide."

In her review of published research on this subject, Dye revealed that evidence from randomized controlled trials supports the conclusion that tea consumption can produce short term acute beneficial effects on attention measured by objective tests such as the attention switching test and on subjective reports of alertness. Studies consistently show beneficial effects of a high dose of L-theanine, together with a lower dose of caffeine, on attention task performance. These findings indicate that the unique combination of caffeine and L-theanine that is found in tea can improve attention.

Tea and the Prevention of Cognitive DeclineWith no effective drug treatments for dementia, prevention is key. It is estimated that 40 to 50% of dementia could be prevented through changes in lifestyle factors. In a review of published research on tea and cognitive decline, Jonathan Hodgson, PhD, Professor at the Institute for Nutrition Research at Edith Cowan University, explains that "there is growing evidence that as little as 1 to 2 cups of tea daily could significantly reduce risk of vascular dementia and potentially Alzheimer's disease."

Recent high-quality data from long-term, prospective cohort studies indicate that higher intakes of tea starting at as little as 1 cup daily and up to 5 to 6 daily are associated with reduced risk for dementia. Data from these studies also find that moderate intakes of the flavonoids present in tea are associated with reduced risk for cognitive decline. Maximal benefits of tea may be obtained from as little as 2 to 4 cups per day, with little additional benefits with higher intakes. Results of these studies also suggest that the protection provided may be strongest for protection against vascular dementia, one of the most common forms of dementia.

Tea and Cancer PreventionIn examining existing data on tea and cancer prevention, higher intakes of tea consumptions may reduce the risk of some cancers. There is evidence that tea flavonoids may act via antioxidant, anti-angiogenesis, and anti-inflammatory mechanisms as well modifying the profile of gut microbiota. Tea is a beverage rich in flavonoids, which are bioactive compounds with several anticarcinogenic properties in experimental studies. Suggestive evidence indicates tea consumption may reduce risk of biliary tract, breast, endometrial, liver, and oral cancer.

"While more research needs to be done to determine the exact dosage, the conclusion we can share is that higher intakes of tea consumptions may reduce the risk of some forms of cancer," says Raul Zamora-Ros, PhD, Principal Investigator at the Unit of Nutrition and Cancer at IDIBELL.

Tea and Cardiovascular HealthCardiometabolic diseases, like diabetes and heart disease, are the number one cause of death worldwide, and tea consumption may be inversely associated with adverse cardiometabolic outcomes, according to results from population studies. Based on an extensive and variety of scientific research designs, 2-cups of unsweet tea per day has the potential to mitigate cardiometabolic disease risk and progression in adults.

In an extensive review on cardiovascular health and tea, research demonstrated each cup of daily tea consumption was associated with an average 1.5% lower risk of all-cause mortality, 4% lower risk of cardiovascular disease (CVD) mortality, 2% lower risk of CVD events, and 4% lower risk of stroke events.

"When you look at all the different biomarkers and mechanisms that tea is affecting, this bountiful beverage is one which consumers can easily add to better their diet and create a healthier and longer life for themselves," explains Taylor Wallace, PhD, Principle and CEO at the Think Healthy Group and a Professor in the Department of Nutrition and Food Studies at George Mason University.

Tea and Dietary GuidanceTo support the growing evidence of tea as a health promoting beverage, clearer recommendations are needed in the current US dietary guidance. "There may be other herbals and botanical products that can deliver health benefits, but none of them are as systematically studied as Camellia sinensis true tea," says Mario Feruzzi, PhD, Professor and Chief of the Section of Developmental Nutrition in the Department of Pediatrics at the University of Arkansas for Medical Sciences. "With true teas white, green, black and oolong - you're dealing with thousands of years of traditional use, 60-70 years of systematic study which, in the last 15-20 years, has ramped up to the point where we have very definitive data."

Dietary guidance will provide more accurate and relevant direction for consumers in the context of the diversity of tea and other flavonoid containing foods.

Sixth International Scientific Symposium on Tea and Human HealthThe Sixth International Scientific Symposium on Tea and Human Health was co-sponsored by the American Cancer Society, American Institute for Cancer Research, American Nutrition Association, American Herbal Products Association, Osher Center for Integrative Medicine at the Harvard Medical School and the Linus Pauling Institute at Oregon State University. To download the media kit please click here.

About the Tea Council of the USA:The Tea Council of the USA is a non-profit association that was formed in 1950 as a joint partnership between tea packers, importers and allied industries within the United States, and the major tea producing countries. It functions as the promotional arm of the tea industry with a primary goal of increasing overall awareness of tea by providing information about its many positive attributes. One of the Council's primary objectives is the dissemination of key scientific findings about tea to the public. The Tea Council does this in several ways including: funding scientific meetings to bring tea researchers from around the world together to share key information and identify next steps for future research projects; and working with health organizations and international scientists to disseminate information about potential positive health effects of tea consumption on a public level.

Contact:

Christina Deecken[emailprotected](212) 941-4906

Eva Walper[emailprotected](212) 941-4906

SOURCE The Tea Council of the USA

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From Immune Function and Cognition to Cardiovascular Health and Cancer Prevention - Health Benefits of Tea Revealed by Researchers from Across the...

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The future of health care: What to expect – CT Insider

Posted: May 2, 2022 at 2:00 am

The last couple of years have seen a seismic evolution in the health care industry. The onset of the COVID-19 pandemic led not just to technological advances such as mRNA vaccines out of necessity it also triggered a quantum leap in how medical practitioners at all levels approach providing care, including an almost overnight revolution in virtual consultations and telemedicine.

To get a glimpse at where all of this may be headed next, we spoke to doctors and health industry experts around the state. Here are 10 changes they see on the horizon, from who you'll deal with (more assistants and women doctors) to how (the return of house calls?)

Your medical care team will expand

The U.S. faces a critical physician shortage, and by 2034, the gap between physician supply and demand will range from 37,800 to 124,000, with shortfalls in both primary and specialty care, according to the Association of American Medical Colleges. Patients in Connecticut should expect to see advanced practice providers (APPs), including physician assistants (PAs), nurse practitioners (NPs), certified nurse midwives (CNM) and certified registered nurse anesthetists (CRNA) filling that gap. These licensed health care providers diagnose and treat patients, prescribe medications and perform or assist with surgical procedures.

APPs undergo extensive education at the undergraduate and graduate school level, with training in both medicine and soft skills such as communication, listening, leadership, compassion and professionalism. On a basic level, NPs, Advanced Practice Registered Nurses (APRNs) and CRNAs are registered nurses with advanced clinical training; a PA is trained following a disease-centered medical model like physicians. The number of people in each profession is expected to grow quickly 31 percent between 2019 and 2029 for PAs and 45 percent for NPs, according to the U.S. Bureau of Labor Statistics.

The need for additional providers came into greater focus during the COVID-19 pandemic, which led to delays in other medical care. That left patients and providers trying to catch up on services, including screenings and chronic-condition follow-up, says Johanna DAddario, president of the Connecticut Academy of Physician Assistants. In many cases, PAs have availability to see patients who need urgent appointments when the physician is not available, she says. It might be helpful for patients to know that PAs work closely with physicians in a team approach, and are able toarrange forthe patient to see the physician as soon as possible when needed.

The medical community is aware of the doctor shortage, but medical school seats are limited. PAs, meanwhile, dont have to do a residency like doctors and can get out into the workforce more quickly than physicians, says DAddario, a physician assistant at Yale New Haven Hospital, but were still limited by the number of seats in PA programs across the country. Physicians, PAs and NAs all need training sites. We have to be very cognizant of not overburdening the current medical system with students.

I work with PAs, nurse practitioners and APRNs. They play a very important role in my own practice, says cardiologist Dr. Bruce T. Liang, interim CEO of UConn Health. If I see a new patient, the next visit could be with a nurse practitioner or a PA. We alternate. Theres mutual respect and dependence. We work as a team. Theresa Sullivan Barger

You might pay a medical membership fee

The future of health care for some looks a lot like health care did a century ago, as doctors fed up with dealing with insurance companies are opening direct primary care (DPC) practices that dont take insurance. Instead, people pay a monthly membership fee for access to their doctor for physicals and sick visits, and, potentially, discounts on medications, tests and health screenings.

In todays health-care delivery system, most private practice primary care doctors have been absorbed by large consortiums. With the fee-for-service, insurance-billing model, clinicians are reimbursed the same amount, whether they spend 10 minutes or 30 minutes with a patient.

Primary care docs have become the gatekeepers. They are loss leaders for hospital consortiums, says Dr. Tonya Cremin, founder of Balance Family Medicine in Monroe. In the fee-for-service model, primary care practitioners send patients to specialists such as a cardiologist for hypertension and an endocrinologist for a thyroid issue, she says. By contrast, Cremin treats people from all walks of life with a full range of health conditions, just like her family doctor did in the small town in which she grew up. When she encounters a challenging case, she checks in with a network of providers to see if her patient needs to see a specialist. As a doctor of osteopathic medicine, she says, she practices holistic, integrative medicine. It saves everybody time and money, she says. Four patients texted her while she was on vacation with what she termed simple problems, she says; she was able to help them and save them a trip to urgent care.

In addition to Balance Family Medicine, the other membership-based practice in Connecticut is 4 Elements Direct Primary Care in South Windsor and Rocky Hill. (There are five hybrid practices in the state which offer a combination of direct primary and fee-for-service care.) Direct primary care is different from concierge medical care, which caters to wealthier patients. Both state DPC practices serve uninsured, middle-class and affluent patients.

DPC practitioners dont need the staff to process claims and argue with the insurance companies for coverage and payment, says Dr. Vasanth Kainkaryam, an internist, pediatrician and the founder of 4 Elements. Some patients pay a monthly fee directly, while some patients membership fees are paid by their employer. Depending on the age of a patient, 4 Elements monthly fees range from $35 or $40 for people under age 40 to $100 for those 65 and older. Cremin charges a flat $100 monthly fee that covers annual physicals, sick visits, disease prevention and maintenance.

Both doctors patients have access to them through in-person visits, phone calls and texting. DPC practices help people save money on prescription medications, lab tests and screenings, Kainkaryam says. After working as a chief medical officer for a large community health center, Kainkaryam says, he learned about the DPC model and was hooked. This is such a better way of giving care, he says. I do house calls. When the weathers nice, well sit outside in the backyard of my office.

When a patient joins my practice, I spend an hour getting to know them, he says. Annual physicals last about 90 minutes, he adds, because health and wellness extend beyond what happens in the office.

According to a study by the Society of Actuaries, DPC patients demand for health services is 53 percent less than patients of traditional practices, they have a 41 percent lower use of emergency departments and 20 percent fewer hospitalizations. In traditional practices, doctors carry a patient load of 2,0003,000 patients and spend an average of 10 minutes with a patient, he says, leaving them little time to get a full picture of what each individual patient is dealing with.

The DPC model may keep some primary care providers from leaving practice, since it allows physicians to spend time with patients and still make a living. Everyone wins, Kainkaryam says. The patient wins because they have direct access to their doctor. The doctor wins because they control their practice. TSB

Demand for mental health care will expand

While the pandemic has caused demand for mental health services to outpace supply, there have been a few upsides. Interest in some careers in mental health is on the rise, a growing societal openness about anxiety and depression has lowered stigma, and patients comfort with virtual visits has skyrocketed. However, at least in the short term, mental health professionals are feeling burnt out and retiring early, and many therapists and psychiatrists positions at Connecticut hospitals go unfilled.

Even with an increase in tele-therapy services, some low-income residents are unable to access therapy, since an internet connection and a smartphone or tablet are required. Increasingly, psychiatrists, psychologists and mental health therapists are switching to private pay and refusing to take health insurance, says Dr. Charles Herrick, network chair of psychiatry for Nuvance Health, further reducing access for less affluent residents.

Mental health care has always been poorly reimbursed and poorly paid, he says. The paperwork demands are so onerous. Mental health clinicians dont have to take insurance, so they dont. More than 50 percent of psychiatrists dont take Medicare or Medicaid. The problem of providers not taking insurance is especially pronounced in southern Fairfield County, he says.

All the hospitals are struggling with staffing. Were down six psychiatrists, he says. I have interviewed so many psychiatrists. They can pick and choose. We are often competing against one another. To address staffing shortages, he says, he applied for and received designation for Danbury and Norwalk as an underserved region and was granted the U.S. State Departments permission to recruit psychiatrists from outside the country with J-1 visas.

On the good-news front, tele-mental health has been so well received by patients and clinicians that its expected to continue. In a UConn Health survey of more than 500 patients, more than 90 percent of adults said they liked virtual therapy and would like the option of it continuing, says psychiatrist Dr. Neha Jain. Its especially beneficial to residents of rural parts of the state where there are fewer mental health providers and to those concerned about the stigma associated with mental health, she says.

She expects behavioral health care to become a hybrid system where people alternate between in-person and virtual visits while also allowing their therapists access to smartphone data that tracks patients movement. For example, clinicians can collect data from patients phones that shows whether theyre leaving their homes. Suppose someone is depressed and has stopped going out? The app is a way for me to track that data, Jain says, and check in with a patient.

However, some mental health apps are unregulated and may not protect users privacy, according to a study published in 2018 in Behavioral Sciences & the Law. I advise people to do their research into who has built this app, Jain says. Are their physicians or institutions familiar with this app? TSB

More screen time with your doctor

Telemedicine isnt a practice that started with the pandemic. The idea of seeing a doctor remotely existed for years before COVID-induced lockdowns temporarily shut down some doctors offices for in-person visits. But it had a hard time catching on, says Jaclyn OConnor, an internal medicine physician and section chief of telehealth at Bridgeport Hospitals Bridgeport and Milford campuses.

Its always difficult to have people accept and adopt new technologies, but COVID sort of provided a need for it, OConnor says. I dont think its going anywhere.

A report released late last year by the U.S. Department of Health and Human Services seems to back that up. The report found that Medicare visits conducted via telehealth skyrocketed between 2019 and 2020, from 840,000 to 52.7 million. The pandemic is largely deemed responsible for that jump, but the Centers for Medicare and Medicaid also announced that it will continue to pay for some telehealth services that were temporarily added to its coverage during the pandemic. These include video-based mental health visits provided by Rural Health Clinics and Federal Health Centers.

OConnor says she hopes the additional spotlight placed on telehealth during the pandemic will also get providers and patients alike thinking about the wide variety of ways in which this technology can be used. We have always thought about telehealth as the next best thing, she says. If you couldnt get there in person, you could settle for this. Now were talking about providing better care to patients than we were before.

For instance, she says, at Bridgeport Hospital and Lawrence + Memorial Hospital in New London (which, like Bridgeport, is part of the Yale New Haven Health system), patient rooms are hardwired with telehealth technology. This allows the cameras associated with televisions in these rooms to accept telehealth calls from providers, including specialists.

Despite the growing interest and innovations in telehealth, there are still some limitations to seeing patients remotely, says Dr. Frank Illuzzi, Hartford HealthCare Medical Groups medical director for Fairfield County. I think this is a tool thats here to stay, he says. I still think its important to see a doctor for regular visits. There are some things telemedicine cant do. Its really hard to listen to someones heart and lungs over the phone. Amanda Cuda

Acquisitions and mergers will continue

Youll see more consolidation of health systems. But will the legislature step in to provide oversight?

Yale New Haven Health recently announced its intention to buy three more hospitals in Connecticut. If they do as they intend, Yale will own nine hospitals. Hartford HealthCare currently owns eight.

That, according to Lynn Ide, mirrors a nationwide trend of health care consolidation in which independent doctors offices are bought by larger groups, a practice called vertical consolidation, and hospital groups buy other hospital groups, called horizontal consolidation.

Now theres a situation where often the hospital is part of a larger system where you live or the two hospitals are both part of larger systems and the doctors and clinics and specialists are all owned by the hospital networks, also, says Ide, director of program and policy at the Universal Health Care Foundation of Connecticut. So it puts consumers in a really difficult position.

Only a few decades ago, Ide says, there were dozens of independent hospitals in Connecticut. Now all but six are part of a larger network. The result is sometimes a consolidation of health care services. At Sharon Hospital, for example, owner Nuvance which was itself formed by the merger of two large health care systems announced its intention to end maternity services. Patients would instead be sent to Poughkeepsie or Danbury.

Consolidation also raises issues around insurance coverage, Ide says. Patients are often only allowed to use health care providers who have an existing relationship with their insurance carrier. In 2015, Hartford HealthCare was negotiating with Anthem Blue Cross Blue Shield, and Anthem wanted to include Hartford in their network of providers, but they couldnt come to an agreement, she says. And so, for a period of time, everybody who lived in my part of the state, in the greater Windham area, had no choice of a doctor to go to because, literally, almost all the practices were owned by Hartford HealthCare.

There is, however, some interest in setting up what Ide calls guardrails. A bill, considered by the state legislature this year, would increase penalties for providers that end services before the state Office of Healthcare Strategy gives its blessing. It would also increase funding to that agency, so it might develop a statewide plan for health care access.

That, Ide says, was surprising. In my years working on this issue, I have never seen the state show so much interest in this issue, she said. Im discouraged, though, because I feel like it may be too late, like the cat may be out of the bag now. Jordan Fenster

The return of the house call?

Dr. Srinivasulu Conjeevaram understands that, for some people, leaving home to see a doctor isnt feasible. The other day a patient called saying, My dad I cant get him out, he just had a heart attack, and needs follow-up help, Conjeevaram says. I help a lot of people who need care and cant get out to the doctor.

Conjeevaram provides medical care in the home to clients all over Connecticut through his Hartford-based business Aakaish Health Care. His practice is one of several throughout the state that provides in-home visits with a doctor or other care provider.

In 1930, house calls by doctors were fairly standard, as about 40 percent of visits happened in patients home, according to the American Academy of Family Physicians. By 1950, though, the number dropped to 10 percent and fell below 1 percent by the mid-90s. That number started to pick up in recent years, according to a 2018 survey by the health care company Landmark Health, which found that about 13 percent of doctorsreported making regular house calls.

Some groups, including the American Academy of Family Physicians, believe the practice is making a comeback. Last year the Academy published an article stating that the U.S. is experiencing a resurgence of home-based primary care. The organization sees several factors at play including the aging U.S. population, an increase in patients who are homebound, and the acknowledgment of the value of house calls by the public and health care industry.

Still, others question house calls growth potential, as technology-assisted home care, including telehealth, can replace some in-person visits.

In his practice, Conjeevaram sees everyone from those suffering from flu to older people who need repeated house calls. He says house calls have a benefit to both the doctor and the patient. Doctors, himself included, have more flexibility in when they see patients, and patients can get help without leaving the home.

But there are drawbacks, Conjeevaram says, including that providers such as himself have to drive all over to see patients. And, sometimes, home care providers cant get to a patient as quickly as they like. It might take a month or so, he says. Its basically how acute the situation is and can you accommodate somebody.

Thats partly why Dr. Jaclyn OConnor says that the nature of what constitutes a house call is changing. House calls will exist where you will have a provider in your home, but theyre going to be there virtually, says OConnor, an internal medicine physician and section chief of telehealth at Bridgeport Hospitals Bridgeport and Milford campuses.

She points to such programs as Hospital at Home, in which patients are admitted to a hospital from their home, but doctors perform their rounds using audio and video visits.

I think house calls are going to look very different moving forward, OConnor says. AC

There will be more women doctors

Nationally, the percentage of female medical students topped 50 percent in 2019, and women have made up more than half of the UConn School of Medicine for at least the past decade, says its dean, Dr. Bruce T. Liang, interim CEO of UConn Health.

Weve seen more qualified women applicants than men applicants, he says, which is a primary reason. Women make good doctors, says Liang, a cardiologist, and patients will benefit from more women physicians. I have learned a lot from my women doctor colleagues. They tend to be more well-rounded with a holistic approach and in listening to patients, he says. Gathering [the patients] social history becomes so important, and if you miss an element of the social history, that can affect the diagnosis.

A study of primary care physicians in the New England Journal of Medicine, published in 2020, showed that women doctors spend 16 percent more time with patients than male doctors.

Having more women doctors will change health care for the better, says Dr. Raman Gill-Meyer, hospitalist-clinician educator in the department of medicine at Norwalk Hospital. Men and women physicians learn from each other, breaking down stereotypical roles, she says. I think women have some innate traits; theyre empathetic, good listeners and skilled at connecting with patients, she says. The more comfortable patients are sharing information with their doctors, the better they can be helped by their doctors.

While, historically, women doctors have tended to be obstetricians and gynecologists, pediatricians and primary care physicians, more women are entering specialties dominated by men, such as urology and orthopedics. Nationally, while only 7 percent of orthopedic surgeons attending physicians are women, 14 percent of orthopedic doctors in training are women, says UConn Healths Dr. Katherine Coyner, an orthopedic surgeon who leads hands-on programs quarterly to introduce girls and young women to medicine and engineering. They get their hands on drills and saws, and learn about orthopedic surgery, says Coyner, a former college basketball player with a 1-year-old child.

Women doctors lives often mirror their patients lives they may also be raising children and running a household while working, and they understand the stress and challenges of balancing multiple roles. Or, Coyner says, they bring an added level of understanding such as a moms need to run to relieve stress or that shoulder pain may make it difficult for a patient to put on her bra. TSB

New vaccine tech is on the way

The technology on which Pfizer and Moderna based their COVID vaccines is being used to develop a variety of treatments, and is being hailed by some as the future of medicine.

I am extremely excited that mRNA technology will expand to many other viruses, including the flu, including combination vaccines, says Scott Roberts, associate medical director of infection prevention at Yale New Haven Hospital. Theyre even trying mRNA vaccines for RSV, and Im sure theyll look at it and HIV and many other viruses.

I think the opportunities are really endless.

Respiratory syncytial virus (RSV) is a common respiratory illness that usually causes mild, cold-like symptoms, but it has proven resistant to vaccines. Theres been a lot of discussion about why vaccines havent really worked with the RSV virus, Roberts says. Maybe its just the virus itself, the way it functions in the human body.

But mRNA technology has made that elusive vaccine seem possible. Recent trials achieved over 90 percent efficacy, Roberts says, something I never would have thought at the beginning of the pandemic.

I think it really speaks to the value of the technology and the opportunity that these vaccines do lend us.

Erol Fikrig is employing the technology in a more creative way. Weve been using mRNA since 2019, about eight months before the pandemic occurred, he says.

The Yale School of Medicine researcher had been working on a vaccine for Lyme disease, with only limited success. Then he attended a conference in Ireland where he met Drew Weissman, who Fikrig calls one of the worlds mRNA vaccine experts.

Fikrig, with Weissmans assistance, has developed a way to combat Lyme disease, not by targeting the pathogen, but its delivery system, the deer tick. Deer ticks feed for as much as 48 hours, but the bite is silent it does not itch or hurt which gives the Lyme bacteria time to go from the tick into the blood. Fikrigs mRNA-based vaccine makes that tick bite red and itchy, causing the victim to remove the tick before the virus has a chance to migrate.

Wed been trying the old, traditional protein-based vaccine for quite some time, Fikrig says. The mRNA vaccine makes you eliminate all those steps. You dont need to make the protein; your body makes the protein. So, in terms of discovery, it made things a lot easier for us for sure. JF

Surgery will become less of a pain

Technology will make your surgery less invasive, more pain-free and less likely to require a hospital stay, says Dr. Maxwell Laurans, vice president of surgical services at Yale New Haven Hospital. I think were going to see advances in technologies that allow us to do new kinds of surgeries, existing surgeries more safely and to move what are typically considered inpatient surgeries to the ambulatory setting, he says.

You now have the ability to put the patients imaging up onto a screen. The image is more reliable and the machine is portable, so it can be used in an outpatient surgical center, Laurans says.

More subtle advances include using TAP (transversus abdominis plane) blocks to numb part of a patients body and avoid narcotics such as morphine. Recovering from narcotics is a main reason for an overnight stay. If you minimize those medications and use these other strategies, now youre taking an operation that used to take four to six hours, lose half a liter of blood and stay in the hospital four days make it safer and the patient goes home at the end of the day and recovers at home, he says.

Nurses will be able to spend more time with patients and less on paperwork with voice-recognition devices that take dictation.

Dr. Nita Ahuja, chair of the Department of Surgery at the Yale School of Medicine and the Yale Medicine board, says you wont see many technological advances theyll be inside you. We will continue to see innovations in cardiac and vascular surgery with increasingly complex stents, and we will start to adopt more innovative approaches to grafts that look quite different to the open heart procedures we have now, she says.

Advances in shrinking tumors before surgery will make cancer surgery more effective, Ahuja says. She also predicts the use of non-human organ transplants that will expand our organ supply and further democratize access.

Your watch and even the blanket keeping you warm will be more high-tech than ever, says Dr. Charles Odonkor, co-director of clinical research at the Wearable Health Lab at the Yale School of Medicine.

These days you have watches that can monitor heart rate, oxygen-saturation levels and can send a signal to the doctor if youre having a seizure, he says. A smart ring can sense vital signs as well, and smart patches can be wirelessly connected to an app on your phone and can monitor what your sugar levels are, he says.

Blankets will be able to auto-regulate body temperature, keeping patients warm and sensing where there may be pressure ulcers developing, Odonkor says. This will be great for patients in nursing homes, he says.

Smart shirts will send out a signal if you are having an attack of atrial fibrillation. But Odonkor believes accuracy, communication between devices and privacy must be improved. There are still a lot of false positives and user errors, and concern that constantly checking a device will increase heart rate. Ed Stannard

Well inch toward preventative care

Insurance plans have historically reimbursed clinicians for treating diseases, ordering tests and prescribing medications when early warning signs appear, not for taking the time to talk to patients about what they can do to reduce the risk of diseases in the first place.

While a full overhaul to prioritize prevention is a long way off, technological advances and medical school training are beginning to shift some patient care toward preventative treatment. In the U.S., a third of all deaths are from heart disease or stroke, according to the U.S. Centers for Disease Control and Prevention. Yet 80 percent of heart attacks and strokes are preventable, says Dr. John Glenn Tiu, a UConn Health cardiologist.

Blood tests will increasingly be used to spot heart disease and cancer risk and manage it once its detected. For example, in addition to the standard lipid panel clinicians order as part of routine annual physicals, if patients have a family history of heart disease or early warning signs, doctors can order a lipoprotein (a) blood test to determine whether the patient is at increased risk for heart-related diseases.

Although not yet fully FDA approved, the Galleri blood test uses artificial intelligence to check the blood for signs of cancer. It was 63 percent effective at identifying 12 types of cancers including hard-to-detect cancers such as pancreatic, ovarian and esophageal at stages 1 to 3, according to a study partially funded by the tests maker, GRAIL Inc. Doctors can prescribe the $950 test, not covered by insurance, for those with a high risk for cancer.

The U.S. Preventive Services Task Forces recommendations for when to start standard cancer screenings such as mammograms and colonoscopies now suggest beginning at younger ages, 35 and 45, respectively, while other standard screening tools, such as the EKG, are no longer a routine part of annual physicals, says Dr. Aesha Patel, family medicine physician at New Canaan Primary Care. Some patients who are overweight and at risk for heart attack, stroke and diabetes can be prescribed medications for weight loss, which can boost the effectiveness of exercise and healthy diet, she says.

Despite the important role diet plays in preventing many of the biggest killers, medical schools traditionally left nutrition education to dietitians. Thats changing at the UConn School of Medicine, says the schools dean, Dr. Bruce T. Liang. Medical students are now taught nutritional science and preventative measures such as exercise, physical therapy, access to fresh air and a break from environmental stressors, he says. Based on research in recent decades into introducing preschoolers to healthy lifestyle practices to prevent cardiovascular disease, pediatricians are sharing with parents the link between healthy habits formed in early childhood and later heart health, Tiu says. TSB

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From Intermittent to Circadian… Different types of fasts, their benefits and drawbacks – Free Press Journal

Posted: May 2, 2022 at 2:00 am

For quite a while now, fitness enthusiasts have been raving about different types of fasts. Each comes with its own set of advantages and disadvantages.

Intermittent fasting: The term may have been coined recently, but this pattern of eating exists since ancestral times. During the old days, the last meal of the day used to be just before sunset because of the lack of electricity, and the first meal was right after sunrise. This automatically gave the human body fasting of 14-16 hours. So, intermittent fasting was, almost, like a way of life for our ancestors. In intermittent fasting, one stops eating after a particular time and moves to only plain water for a specific period, and then slowly resumes eating. The phase in which one fasts is called the elimination phase and the phase in which one feeds is called the building phase.

Intermittent fasting benefits our body beyond weight loss. It helps our digestive system take a complete break which is not only healing to the digestive system but the entire body. It boosts our immunity, calms down inflammation and is termed a natural pain killer that works amazingly well for any arthritic pains. It helps in detoxification. It is also anti-aging and boosts skin and hair health.

Who shouldnt do it?

While the benefits of intermittent fasting are powerful and are recorded in medical and scientific journals, it does not suit everyone. Below are some cases where intermittent fasting must be avoided or practised only under medical supervision.

Dos

First, set the right intention when you fast. The intention is everything. Do not fast with the intention to only lose weight. Fast because it helps you become disciplined and align with nature. Fasting is not a shortcut to losing weight and it shouldn't blind you from making lifestyle changes.

During intermittent fasting, drink only plain water in the fasting phase. No tea, coffee, or infused water as anything other than water. If one wants to adopt fasting, one must do it the right way.

Thirdly, set the timings, eating patterns, and hours of fasting according to what suits you and your lifestyle. Don't fast for 16 hours just because everyone else is doing it. If you are a beginner, start slow and build up gradually.

In the building phase, make sure you really eat well. Dont diet in the building phase, else you will only cripple your metabolism. Get your macros and micros, vitamins, and minerals. Fasting is not starvation. In fact, if one doesn't nourish well, they might end up looking undernourished, weak, and haggard.

Donts

Wet fasting: Wet fasting means drinking only plain water during the fasting window and resuming eating as usual when the fasting period is over. A lot of people bring in juices, tea, coffee, infused water, and other beverages in the name of wet fasting. However, it is important to understand that putting anything other than water, in your system will make your digestive system work instead of putting it to rest. Therefore, remember to drink only water.

Dry fasting: Dry fasting is a step ahead of intermittent fasting. Here, one does not consume even water during the fasting period. This is powerful because it gives a complete break to our digestive system, and redirects all the energy towards healing, recovering, cleansing, repairing and other vital functions. Dry fasting can also be eased into wet fasting, which is called integrated fasting.

The mechanism of dry fasting is simple. Our digestive system is the largest consumer of our bodys energy. It utilises almost 80% of the energy into digestion, absorption, and assimilation, leading 20% of the energy towards healing, repair, recovery, growth, rejuvenation, detoxification, immune system. Too much eating, eating at the wrong timings, or overeating can direct all energy towards digesting, leaving little or no energy for repair and recovery. When one fasts the body's energy is redirected towards healing, repair, rejuvenation, boosting the immune system, stem cell regeneration, hormonal imbalance, etc.

Dry fasting activates our bodys intelligence to do what it needs to do. Due to the absence of water, dry fasting helps reduce inflammation.

Fasting is healthy if it suits you, your health and makes you feel better. Most of us need to let go of the idea that 16:8 fasting is good for us. What if your body doesn't need 16 hours of fasting, and can operate at its optimum with just 12 hours of fasting? All of us are unique bio individuals, so fasting must be as personalised as nutrition or exercise. The one shoe fits all approach will not work here as well.

Circadian fasting: By far, one of the most natural ways of fasting that have worked for most people who have followed it with discipline and consistency is circadian fasting, which aligns the fasting and feeding window with the circadian rhythm (sunset and sunrise). This type of fasting results in a natural 12-hour fast. We utilise the power of circadian rhythm, which has a deep connection with digestion, detoxification, repair, and recovery.

(The writer is a Holistic Nutrition and Lifestyle Integrative and Lifestyle Medicine, Founder of YouCare All about YOU by Luke Coutinho)

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New details behind the body’s response to tuberculosis could lead to a more effective vaccine – EurekAlert

Posted: May 2, 2022 at 2:00 am

BOSTON More than 1.7 billion peopleor a quarter of the worlds populationare infected with Mycobacterium tuberculosis, the bacterial strain that causes tuberculosis (TB). For years, scientists have been working to develop an effective vaccine, but current TB vaccines are only partially protective. New research by a team including investigators at Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), the Ragon Institute of MGH, MIT and Harvard, and the Harvard T.H. Chan School of Public Health (Harvard Chan) has identified helpful and unhelpful aspects of the immune response that determine whether the body can keep TB infections under control. The findings, which are published in Immunity, may be helpful for designing a more effective vaccine.

Although the bodys immune system can often keep M. tuberculosis infections under control so that people dont experience any symptoms, there were more than 10 million active cases in 2017, with 1.6 million TB-related deaths. In response to active infection, which usually attacks the lungs, the body forms granulomastiny clusters of immune cells and other tissue-resident cells. In some granulomas, immune activity promotes bacterial clearance, but in others, bacteria persist and grow. These different granuloma responses can even be seen in the same individual.

Identifying which cellular and molecular features associate with bacterial control could potentially point to new therapeutic and prophylactic strategies for TB, says cosenior author Alex K. Shalek, PhD, a principal investigator who conducts research through the Ragon Institute of MGH, MIT and Harvard as well as through the Institute for Medical Engineering and Science, the Department of Chemistry, and the Koch Institute for Integrative Cancer Research at MIT and the Broad Institute of MIT and Harvard. To do so, Shalek and his colleagues used their single-cell profiling tools and teamed up with scientists in the lab of JoAnne Flynn, PhD, at the University of Pittsburgh School of Medicine, who had helped develop a monkey model that recapitulates the features of human TB and had also devised ways to track and quantify bacterial load and killing in individual granulomas.

With TB, the immune response is pretty good but not great, and until recently, the field has tackled that problem with very rudimentary tools. This collaboration is bringing the very best tools and the very best minds to bear on a really hard, really important problem that most of the world ignores because it primarily impacts the global poor, says cosenior author Sarah Fortune, MD, chair of the Department of Immunology and Infectious Diseases at Harvard Chan and an associate member of the Ragon Institute.

The collaborators efforts revealed that bacterial persistence occurs in granulomas enriched with certain cellsspecifically mast, endothelial, fibroblast and plasma cellsthat signal amongst themselves via particular pathways. Granulomas that supported bacterial clearance are characterized by other kinds of cellsincluding type 1-type 17, stem-like, and cytotoxic T cellsand use other types of signaling pathways.

Our findings highlight new targetssuch as specific cell subsetsto guide next-generation vaccines, says Shalek. We can also begin to consider how we might directly manipulate entire granulomas through modulating intercellular signaling to combat the bug more effectively.

Fortune stresses that until the COVID-19 pandemic, TB was the leading cause of death from infectious disease worldwide. An effective vaccine is the only way that we are really going to control TB, which shares many of the features that has made controlling COVID-19 hard: its airborne transmission, its infection in many people, and its ability to transmit before people are diagnosed, she says. Unlike COVID-19, which is caused by a virus, TB is caused by bacteria, and current treatment involves multiple months of aggressive antibiotic therapy. This studys new insights into how the immune system clears, or in some cases helps, TB are critical in figuring out what a new vaccine should do, says Fortune.

This work was supported by the Bill and Melinda Gates Foundation, Searle Scholars Program, the Beckman Young Investigator Program, Sloan Fellowship in Chemistry, the National Institutes of Health, the American Lung Association, the National Science Foundation, Fannie and John Hertz Foundation Fellowship, and Wellcome Trust Fellowship.

About the Massachusetts General HospitalMassachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Instituteconducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2021, Mass General was named #5 in theU.S. News & World Reportlist of "Americas Best Hospitals." MGH is a founding member of the Mass General Brigham health care system.

Experimental study

Animals

Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control

27-Apr-2022

A.K.S. reports compensation for consulting and/or SAB membership from Merck, Honeycomb Biotechnologies, Cellarity, Repertoire Immune Medicines, Third Rock Ventures, Hovione, Relation Therapeutics, FL82, Empress Therapeutics, Ochre Bio, and Dahlia Biosciences.C.L. is a shareholder and consultant for Honeycomb Biotechnologies. T.K.H. is a shareholder and consultant for nference, inc.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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#Pandemica: Adapting and Integrating to the New World – Digital Journal

Posted: May 2, 2022 at 2:00 am

The Issue

The world had taken a deep break and was having doubts about continuing to revolve, Maya Angelou says in her 1969 memoir, I Know Why the Caged Bird Sings. What if the world has started revolving and it is you who has doubts about continuing to revolve in it?

This is a totally normal response to an extraordinary life event that to some may not seem real and to others who have lost loved ones, work, finances, friends, and even a part of themselves, it is all too real. You cannot un-feel it. How do we begin revolving again at our own comfort level? Or maybe you do not want to revolve endlessly as in pre-pandemic life because, in your mind-without having to explain or justify it-it is just too risky. What if both answers were acceptable and there was no wrong way for any one person to re-acclimate to before times?

Busy Busy Americans

Pre-pandemic, there were idiosyncratic sayings like FOMO and YOLO mirroring the pioneering American spirit of seizing the day. If you work hard enough at work, at nutrition, at health, it was essentially all in your control, including planning your day. Pre-pandemic life was filled with the illusion that we were in control of our work, relationships, and daily habits. We loved to be so busy with work, busy with friends, working out, family, etc. That ended abruptly and everyones life was literally stopped, and unfortunately for so many, literally.

Pandemic FOMO

Pandemic FOMO is a real thing that people are experiencing as the world opens again, though many are not quite ready for it to go back to the way it was-and still, countless others who may have different risk tolerance or physical ailments, who may need more time before getting back to any sense of normalcy, if at all. That is the thing about pandemic FOMO, that it is out of our control depending on all of our individual risk factors or idiosyncrasies, and life may not look at all like what it looked like back in February of 2020. There are (by choice or by not) radical changes that have shifted peoples identities, relationships with friends and families, and work that may be forever altered or lost. All of this is contributing to a collective, familial, and individual trauma in addition to the major life disruptions that have happened globally.

Trauma: The Pandemic Created a Global, Collective, and Individual Trauma

Carl Jung, Americas spiritual psychologist, was the first to discuss collective, family, and individual trauma. These all run together and are each distinct. Until we acknowledge the struggle, we cannot integrate a new way of living, being, and communicating. Although we have less control now than we thought we did over what happens to us (psychologists and doctors have always realized that we have less control over our lives than we want to accept on a conscious level), our self-agency has had to bolster itself to get through this time. It is not an easy adaptation backward. The pandemic has also emboldened a culture of rudeness and entitlement-part of the Are you in? or Are you out? paradigm that has emerged. This is low-level, crisis, animal brain thinking and functioning.

Healing From Trauma: High-Level Thinking

To heal from trauma, we must slow down and shed the fight or flight and busy busy busy all the time mentality so prevalent in American culture. All the busyness before the pandemic did not leave time or facilitate the existential dilemma many of us are dealing with as the world reopens and we may not be ready for it to do so. The pandemic also exposed many other viruses that the world is fighting, such as poverty and inequity. Like a Band-Aid being ripped off, many of us are newly aware of the gravity of ills and inequities exposed from the convergence of events in the spring/summer of 2020, and we are without healthy coping mechanisms for the new reality that pre-pandemic life is gone and we are in a new phase of integration. In general, Americans are not comfortable with thinking that they are not in control of their lives, their work, finances, etc., and integrating the new reality takes new skills of adaptation we have not seen or needed before.

Adapting and Integrating to the New World

One virus that no one discusses but goes to the heart of the issue (now that we have been forced to have the space to face existential questions of identity and self) is how people were able to take the time to reflect and ask, Am I happy being so busy? Am I comfortable with the world reopening? Why am I the only one with a mask on? Or how you may not have felt comfortable when your friends invited you to a concert and it puts a real rift in the connection. It seems that because without mindful adaptation, people are using binary models as a primitive fight or flight response-and the You are either with us or against us mentality seems present. It is not so simple at all. The pandemic has exposed our hearts to ourselves and made us rethink what is right on an individual level that may not flow with friends or family or work anymore We have to dig deep to communicate these differences in risk tolerance without disrupting those connections because there is still hope that one day we will get to a new normal.

How to Fix It? Remedies for Pandemic FOMO

Practice mindfulness. What am I feeling? Really focus on the emotion, whether it is joy or grief or sadness-do not judge it; just be with it-and slowly breathe in and out through the emotion not trying to change it or fix it. Just let it be and it will pass with deep breathing and some gentle mindfulness.

Practice radical self-acceptance. Acknowledge that we all have different motivations and reasons and accept that we all have to make, live or die by our choices; so, it is critical to honor yourself without judgment or criticism. It is okay if you are fearful and uncomfortable. There is no race or timetable to get back to the busyness of the world.

Practice radical self-care. Grounding every day by walking in grass, taking a bath with Epsom salts (widely believed in the integrative medicine field to calm the nervous system), and treating yourself as you would treat your grandparent or child if he or she were sick. Practice that kindness on yourself, especially in a world that is moving faster and more abruptly than we would want it to.

All we are is dust in the wind. Practice aligning yourself with a universal presence-could be spirituality, could be religion, or could just be nature, but find something outside of yourself that is meaningful to you and does not place you at risk if you are not comfortable with everyones different levels of risk-taking.

What Will This Psychobabble Do for Me?

Radical acceptance and radical self-care are the heart and souls way to find resilience and hope. We have to be captains and stewards of ourselves. So, as America enlivens itself again and pushes boundaries that many are not ready to face yet or ever again, we must practice accepting those feelings, whether momentary or lasting, without judgment or reprisal. That is the one thing you can control. You do you. To regain a sense of self-agency, let all else fall away. After all, we must remember that despite everything we have seen and been through, ultimately, the human spirit is resilient, and hope always springs eternal.

About the Author

Hope Phillips Umansky, PhD, Consulting Psychologist, American Culture Professor.

Dr. Hope, as she is professionally known, is an esteemed professor, keynote speaker & author. As a professor, her expertise is in American culture, Writing & Rhetoric, and Leadership. Additionally, after a near-decade as a CEO for a clinical and integrative psychology and integrative health graduate institute, Dr. Hope also now works as consulting psychologist and strategist.

Find Dr. Hope on the web:

Dr. Hopes Psycho-Edu Consulting Site [https://innovationsadvocacy.com]

Hope Health and Healing, Consulting & Integrative Psychology [https://hopehealthandhealing.org]

Dr. Hope On Point [https://www.askdrhope.com]

Available for Media Interviews:

Contact: Jo AllisonPhone: 917-207-1039Email: [emailprotected]Website: http://www.MediaAmbassadors.com [https://www.mediaambassadors.com/dr-hope-umansky]

Or, Contact:

Dr. HopeEmail: [emailprotected]Website: https://www.askdrhope.com

Media ContactCompany Name: Media AmbassadorsContact Person: Jo AllisonEmail: Send EmailCountry: United StatesWebsite: https://www.MediaAmbassadors.com

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What Is The Cannabis And Mushroom Combo That Kills 90% Of Colon Cancer Cells? – Benzinga – Benzinga

Posted: May 2, 2022 at 2:00 am

This article was originally published on Cannabis.net and appears here with permission.

According tostatistics, there are going to be over 106,000 new cases ofcolon cancerthat going to be diagnosed this year alone.

Cases of colon cancer have been increasing steadily in the United States since the 1990s especially among young adults, as this disease usually afflicts the elderly. Generally speaking, the survival rate for colon cancer survivors is just 64% but if its diagnosed in a localized stage, the prognosis increases significantly to 91%.

There is a dire need to develop more advanced medical solutions to address the growing colon cancer cases in order to save lives.

Now,Cannabotech, anIsraelibiomedical firm that innovates botanical-based solutions for oncology and preventive medicine, has found promising results in an experiment involving its Integrative-Colon product, based on apress release. The formula combines mushroom extractstogether with cannabinoidsfrom the cannabis plant, then tested on various subtypes of colon cancer. They found that the ingredients of the formulation acted more effectively compared to isolating the cannabinoids, and that the active ingredients showed great synergy working together. Based on the findings, the Integrative-Colon product was able to kill more than 90% of colon cancer cells

The mushroom extracts had a high concentration of PSK, which is derived from the Trametes mushroom, renowned for its cancer-fighting properties. In fact, the Trametes mushroom has already been approved for cancer treatments in South Korea, Taiwan, and Japan. They intend to combine the formulation with conventional chemotherapy treatment in the next phases, and also combine it with the Cyathus Striatus mushroom.

In addition, their study shows that there are different impacts of each cannabinoid on various colon cancer subtypes. According to Cannabotech, it demonstrates the importance of personalizing medical care for each patients unique needs. However, the goal of Cannabotechs work is not to completely replace conventional cancer treatments though they hope that with the new formulations, cancer patients need less treatments in order to get the same benefits.

We know that patients need a minimum amount of chemo, but a lot of people cant survive this because of side effects, so they stop the treatment, said Elchanan Shaked, Cannbotechs CEO toIsrael21c.

This is a significant milestone in Cannabotechs growth to becoming a leader in integrative oncology medicine. The integrative products developed by Cannabotech are intended for use in combination with chemotherapy treatment to reduce its side effects. Cannabotechs solutions will be launched in Israel and the US towards the second half of 2022, while the companys goal is to define a new standard for the medical cannabis industry, said Shaked.

They are currently studying 5 cancers aside from colon cancer, the others being breast cancer, prostate, lung, and pancreatic. CannaboBreast, their breast cancer product, has so far already been developed furthest along, having been tested on various breast cancer subtype and they have adjusted the treatments based on the subtype.

While many studies are focused on the benefits of magic mushrooms which contain psilocybin, Cannabotech utilizes some of the many other medical mushrooms that have healing benefits. In fact, back in 2015, Shaked was traveling to Nepal on business when he first heard about mushrooms. A local entrepreneur was collecting mushrooms from the locals and selling them to the Indian alternative pharmaceutical industry, Shaked told Israel21c. He wanted to examine the effectiveness of those mushrooms.

This piqued the interest of Shaked so once he got back home to Israel, he linked up with Prof. Solomon Wasser, who heads the International Center for Biotechnology and Biodiversity of Fungi at the Institute of Evolution at the University of Haifa. He also spoke with Prof. Fuad Fares, director and founder of the Carmel Medical Centers molecular genetics unit, and an associate professor of human biology in the University of Haifa.

Cannabotech is seeking to release a personalized cancer treatment kit by the middle of this year.

The anti-cancer benefits of cannabis is already well-documented, but what about the trametes mushroom?

Trametes, more famously known as the turkey tail mushrooms, contain naturally-occuring compounds known as the PSK (polysaccharaide-K) and PSP (polysaccharopeptide). There have beennumerous studiesconducted showing the efficacy of these compounds in fighting cancer. The Chinese have been drinking turkey tail extract for centuries in traditional medicine, where its known as Tun Zhi.

Aside from the Chinese, the turkey tail mushroom is prized in other Asian cultures including Japan. It is a symbol of health and longevity as well as infinity and spiritual attunement. Other uses of turkey tail mushroom in traditional medicine include strengthening the lungs and respiratory function, spleen, stomach, and overall immunity.

It grows in the wild, usually found on dead hardwood trees around the world. This mushroom is 100% vegan.

While there are more studies being done, heres what we know:

In a2008 scientific review, researchers proposed investing more on researching turkey tail mushrooms and its PSK content for breast cancer. The researchers suggested that it can be used as an add-on treatment to boost immunotherapy after the initial treatment for breast cancer such as chemotherapy or surgery. In 2012, asmall studyfollowed up on this; though it only had 9 subjects, the researchers found that consuming Trametes versicolor orally through powder form significantly improved the immunity of breast cancer patients.

Then in 2019,another studyexamined the impact of turkey tail mushrooms combined with hen-of-the-woods mushroom. Amazingly, both mushrooms were shown to be effective in preventing the spread of cancer cells; they also enhanced the anti-cancer properties of 5-fluorouracil, which is usually used for treating colorectal cancers.

There was areviewconducted of 8 studies, including over 8,000 people who had gastric cancer. After adding PSK to their treatment plan and chemotherapy, the studys findings showed that their prognosis improved and the patients were able to live longer.

Given all the exciting therapies being developed, and considering how powerful the combination of cannabis and mushrooms are, we hope to see these treatments go mainstream to save more peoples lives.

This article was submitted by an external contributor and may not represent the views and opinions of Benzinga.

2022 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

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Procreating Robots: The Next Big Thing In Cognitive Automation? – Forbes

Posted: May 2, 2022 at 1:58 am

The concept of automation in business and non-business functions has undergone more than a few evolutions along the way. The earliest types of automation-related applications could only carry out repetitive tasks such as printing and basic calculations. In a bid to save time and minimize human error, such applications were used by businesses and individuals to automate the tasks that, according to organizations, employees didnt need to waste their energy on. The eventually widespread adoption of IoT, AI and robotics resulted in the growth of cognitive automation to execute more challenging, diverse and multifaceted functions such as supply chain operations, robotic surgery, architecture and construction.

The sheer accuracy and consistency of cognitive automation tools powered by AI and robotics allow organizations to evaluate data at lightning-quick speed, predict future trends in consumer demand patterns and formulate robust strategies and frameworks for improved operational efficiency and regulatory compliance. In domotics, cognitive automation brings innovation in the form of smart kitchens, pervasive computing for elder care and autonomous smart cleaners.

Now, AI and robotics are about to witness another giant leap forward with the brand-new concept of self-replicating, alive robots known as xenobots.

For several reasons, xenobots are a great leap forward from standard AI and robotics applications of the past. One of the reasons is that such "living" robots may finally enable data scientists, tech developers, businesses and governments around the world to finally create Artificial General Intelligence (AGI). In basic terms (as the concept has a wider meaning too), AGI makes it possible for machines and digital applications to comprehend and perform intelligent tasks that humans do. AGI, currently just a concept, involves robots and smart tools possessing high levels of sentience and machine consciousness to definitively think like humans and make decisions or carry out functions autonomously with the ruthless efficiency of a machine while possessing the strategic nous and short-notice adaptability of the human brain. Xenobots were first developed by researchers at the University of Vermont, US.

Also referred to occasionally as alive robots, Xenobots possess a few peculiarities that set them apart from any other existing AI and robotics-based applications. For instance, xenobots are created using an amalgamation of robotics, AI and stem cell technology. The creators of the technology used stem cells from the African clawed frog (its scientific name is Xenopus Laevis) to create a self-healing, self-living robot that is minute in sizexenobots are less than a millimeter wide. Like natural animal and plant cells, the cells used to create xenobots also die after completing their life cycle. Their minute size and autonomy allow xenobots to enter the human body, micro-sized pipelines or underground or extremely small and constricted spaces for performing various kinds of tasks. Additionally, such robots are extremely sturdy despite their tiny size. In this way, xenobots show a passing resemblance to nanobots. Although nanobots are much smaller as compared to xenobots, both are used to perform tasks that require the invasion of micro-spaces to carry out ultra-sensitive operations. Technologies such as AI and robotics, combined with stem cell technology, allow such robots to perfectly blend in with other cells and tissues if they enter the human body for futuristic healthcare-related purposes. One of the biggest advantages of xenobots is their stealthy nature, which enables them to blend in with the surroundings during any operation.

And now, the most important detail of xenobotsthey can replicate autonomously and create an army of themselves within no time. Basically, xenobots closely follow the reproduction mechanism of actual cells in plants, animals and other organisms that are found in various ecosystems around the globe. The stem cells within xenobots can undergo endless fission to set in motion a chain of self-replication that can be useful for various kinds of tasks. Although xenobots are a fairly new concept and possess no known and tried applications, their main working mechanism draws parallels with swarm robotics, an AI and robotics subsection involving collective robots that function in perfect sync with regards to each others movement to carry out complex functions, such as supply chain assembly line distribution and redirection.

As stated above, there are not many known publicly-carried out applications of xenobots currently in use. So, any use of the AI and robotics-driven technology involves a certain degree of assumption and hypothetical predictions.

Procreating robots- The next big thing in cognitive automation

As stated earlier, xenobots are extremely tiny and mobile. Those attributes are a necessity in healthcare, especially during complex and sensitive operations, when an individuals life is on the line. On diagnosing malignancy in individuals, healthcare experts can release xenobots into their bodies. Using elements of AI and robotics, xenobots can then detect and locate not only the tumor within a persons body but also the factors directly causing and enabling it to enlarge unabated. Cancer, as you know, needs to be detected at an early stage when a tumor is just being formed to have any realistic chance of stopping it. To detect cancer, doctors can create a xenobot using the cells of a cancer patient themselves using the incredible blending ability of the technology. This serves two purposesfirstly, with the help of computer vision, AI and robotics, doctors can exactly know the location, malignancy status and severity of a tumor by checking details related to the blood flow and organ health. Secondly, the presence of cells of the patient on the xenobots within their body will not trigger massive immune system responses as there are no foreign bodies involved in the procedure at all. Once all these elements fall into place, tumors or precursor cells to a tumor can be taken out of a patients body via surgery.

There are several other ways in which xenobots can be utilized by healthcare experts. Another example is during major bypass surgeries in heart patients. As you may know, these kinds of operations require surgeons to remove the blockages caused by unsaturated fats and other similar elements within the arteries of an individual. The operation is tricky and even a single misstep could lead to life loss. Micro-sized xenobots can enter the bloodstream of a patient, circulate all around the body without undergoing damage and carry out the taskremoving blockades within their arteries and veins. In this way, xenobots treat persons from within their bodies. Once the life-cycle of a xenobots cells is over, they can die like other normal cells.

Further advancements in AI and robotics will bring operations such as the two listed above closer to reality from its current concept stage.

Apart from healthcare, xenobots have use in environmental sustainability too. Smart cities, where urban computing connects several pieces of technology scattered across various zones, can use xenobots for pollution monitoring and control. Xenobots will possess advanced AI and robotics tech, such as the memory of harmful toxins that can cause pollution-related issues in smart cities. Smart city authorities can use the information gathered and analyzed by xenobots to keep control of pollution. Xenobots can also link up with the urban computing network in smart cities to detect novel viral particles in the air or water before alerting the appropriate smart city authorities about it. This can be used to prevent potential disease outbreaks and pandemics in heavily crowded zones in smart cities.

As stated earlier, xenobots will boost swarm intelligence. This will involve several tiny robots working to carry products into packaging, transport or other functional lines in a multi-way assembly line. Packages can be directed anywhere within a given assembly line just by the swarm intelligence tools aligning with each other in specific ways. This application will be further optimized by xenobots self-replication abilitiesallowing the robots that have broken down to be replaced in real-time and keep the assembly line in the factory running continually.

There may be a thousand different ways in which procreating robots will impact various sectors. Most importantly, the "living and thinking" nature of this application brings it closer to AGI. That will mark a monumental step forward for AI and robotics in the future.

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Procreating Robots: The Next Big Thing In Cognitive Automation? - Forbes

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La Conner native raising funds to cure blood cancer – La Conner Weekly News

Posted: May 2, 2022 at 1:57 am

There are few things more grueling than running a marathon.

One of those is battling cancer.

A La Conner native knows all about the former, having previously run the Denver Colfax Marathon. Now shes helping bring greater awareness to the latter by raising funds for the Leukemia & Lymphoma Society as she trains for the Chicago Marathon in October.

Morgan Harlan, a 2020 Baylor University grad now teaching kindergarten in Denver, is hoping to raise $4,000 for LLS by running the urban Chicago course with two friends this fall. The Chicago Marathon is typically viewed by more than a million spectators.

I hope to raise as much money as I possibly can for such a worthy cause that is so important to my family, she told the Weekly News on Friday.

Her family has seen first-hand the life-saving potential of bone marrow and blood stem cell transplants, and is committed to helping find cures and ensure access to treatments for all blood cancer patients.

Harlans grandfather, longtime La Conner resident and Dunlap Towing retiree Mit Harlan, waged a successful battle against leukemia over a decade ago.

My grandfather, said Harlan, is alive because of a stem cell transplant.

While a student at Baylor, where she was a journalism/public relations major and played club soccer, Harlan signed up for Be the Match, which connects patients with transplant donors.

As a college student with a family member who had experienced cancer, said Harlan, I thought I was doing my due diligence by signing up for the registry.

Last December, four years after joining Be the Match, Harlan flew to Seattle to donate her stem cells.

Her patient was a 65-year-old male with leukemia the same age her grandfather was when he received his transplant.

When Be the Match called to inform me that I was the match and asked me if I would be willing to donate my stem cells, Harlan added, my response was: Absolutely. I hope I can give another little girl or boy more time with their grandpa like I was given.

Harlan has not stopped there. She has taken on fundraising for the cause, doing so in a way that shows she is in it for the long run.

She has enlisted a coach, La Conner alum Carlee Daub, to help her train for Chicago. Daub is an owner of Wahoo Running, an online platform that provides coaching to runners throughout the nation.

My first marathon, Harlan recalled, I was focused on completion. I wanted to prove to myself that I had the physical and mental grit to get through 26.2 miles. The Chicago Marathon will be focused more on speed and race strategy.

As Harlan has lowered her running times, her fundraising numbers have increased.

My fundraising has gone really well because of the wonderful people around me, she said. I am very thankful to have generous family members, friends, and community members.

My original goal was to raise $2,000, Harlan explained, which I was able to raise in the first week. I have since raised my goal to $4,000.

Committing to run the Chicago Marathon on behalf of LLS is a big step for Harlan. After graduating from Burlington-Edison High School, having competed in soccer and track there, Harlan chose to go out of state for college.

I wanted to travel outside of Washington for my four years of college and live somewhere new, she said. Baylor had a great mix of academic strength, athletics success and extracurriculars.

While on the Waco, Texas campus, Harlan regularly wrote for the student newspaper, the Baylor Lariat.

Now, as she preps for the Chicago Marathon and generates support for LLS, Harlan is making rather than reporting the news.

For her, its a story whose headliner is her grandfather.

Hes one of the best humans I know, said Harlan. Growing up, he never missed a soccer match (of mine), including a tournament in Spain. Hes very giving with his time and money, especially towards charities like LLS.

Harlan, daughter of Mike and Jennifer Harlan, of Landing Road, southeast of La Conner, said the best ways to donate are through either her donation page: (https://pages.lls.org.tnt/rm.chicago22/MHarlan) or Facebook.

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La Conner native raising funds to cure blood cancer - La Conner Weekly News

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CORRECTING and REPLACING — Affimed NV – GlobeNewswire

Posted: May 2, 2022 at 1:57 am

In a press release issued earlier today by Affimed N.V. (Nasdaq: AFMD), please note that the headline named an incorrect organization. It should have mentioned the annual meeting of the American Society of Clinical Oncology (ASCO), not the American Association for Cancer Research. The corrected release follows:

Affimed Announces Clinical Update and Trial in Progress Posters at the Annual Meeting of the American Society of Clinical Oncology (ASCO)

HEIDELBERG, Germany, April 27, 2022 (GLOBE NEWSWIRE) -- Affimed N.V. (Nasdaq: AFMD), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, today announced that four abstracts with clinical trial designs and clinical data of its innate cell engagers (ICE) have been accepted for presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting, taking place June 3-7, 2022 in Chicago, IL.

The events include an oral presentation by Yago Nieto, M.D., Ph.D., professor of Stem Cell Transplantation and Cellular Therapy at The University of Texas MD Anderson Cancer Center with an update of the study that evaluates AFM13 pre-complexed with NK cells in patients with relapsed/refractory CD30-positive lymphomas. In addition, three Trial in Progress posters will be presented to provide background information and introduce the study design of the three ongoing AFM24 studies in which patients with EGFR-positive solid tumors are treated with AFM24 monotherapy or combinations with either Roches checkpoint inhibitor atezolizumab or NKGen Biotechs NK cell product SNK01.

Oral presentation details:

Title: Innate cell engager (ICE) AFM13 combined with preactivated and expanded cord blood (CB)-derived NK cells for patients with refractory/relapsed CD30+ lymphoma

Authors: Yago Nieto, Pinaki Banerjee, Indreshpal Kaur, Roland Bassett, Lucila Kerbauy, Rafet Basar, Mecit Kaplan, Lori Griffin, Daniel Esqueda, Christina Ganesh, Melissa Barnett, Amin Alousi, Chitra Hosing, Jeremy Ramdial, Neeraj Saini, Samer Srour, Sairah Ahmed, Swaminathan Iyer, Hun Lee, Ranjit Nair, Raphael Steiner, Karenza Alexis, Andreas Harstrick, Elizabeth J Shpall, Katayoun Rezvani

Oral session: Hematologic Malignancies Lymphoma and Chronic Lymphocytic Leukemia, Friday, June 3, 2022, 1:00 - 4.00 p.m. CDT

Poster details:

Title: A phase 1/2a open label, multicenter study to assess the safety, tolerability, pharmacokinetics, and efficacy of AFM24 in patients with advanced solid cancers: Study design and rationale.

Authors: Omar Saavedra Santa Gadea, Elena Garralda, Juanita Suzanne Lopez, Mark M. Awad, Jacob Stephen Thomas, Crescens Diane Tiu, Daniela Morales-Espinosa, Christa Raab, Bettina Rehbein, Gabriele Hintzen, Kerstin Pietzko, Paulien Ravenstijn, Michael Emig, Anthony B. El-Khoueiry

Poster details:

Title: AFM24 in combination with atezolizumab in patients with advanced EGFR-expressing solid tumors: Phase 1/2a study design and rationale.

Authors: Omar Saavedra Santa Gadea, Eric Christenson, Anthony B. El-Khoueiry, Andres Cervantes, Christa Raab, Ulrike Gaertner, Kerstin Pietzko, Gabriele Hintzen, Paulien Ravenstijn, Daniela Morales-Espinosa, Juanita Suzanne Lopez

Poster details:

Title: The combination of CD16A/EGFR innate cell engager, AFM24, with SNK01 autologous natural killer cells in patients with advanced solid tumors.

Authors: Anthony B. El-Khoueiry, Paul Y. Song, Jennifer Rubel, Dorna Y. Pourang, Christa Raab, Gabriele Hintzen, Michael Emig, Pilar Nava-Parada

Poster session for all posters: Developmental Therapeutics Immunotherapy, Sunday, June 5, 2022, 8:00 11:00 a.m. CDT

Abstract release: The full abstracts will become public at 5:00 p.m. EDT on Friday, May 26.

More details about the programs for the ASCO Annual Meetings are available online at http://www.asco.org

About AFM13

AFM13 is a first-in-class innate cell engager (ICE) that uniquely activates the innate immune system to destroy CD30-positive hematologic tumors. AFM13 induces specific and selective killing of CD30-positive tumor cells, leveraging the power of the innate immune system by engaging and activating natural killer (NK) cells and macrophages. AFM13 is Affimeds most advanced ICE clinical program and is currently being evaluated as a monotherapy in a registration-directed trial in patients with relapsed/refractory peripheral T-cell lymphoma (REDIRECT, NCT04101331).

In addition, The University of Texas MD Anderson Cancer Center is studying AFM13 in an investigator-sponsored phase 1/2 trial in combination with cord blood-derived allogeneic NK cells in patients with relapsed/refractory CD30-positive lymphomas (NCT04074746).

About AFM24

AFM24 is a tetravalent, bispecific innate cell engager (ICE) that activates the innate immune system by binding to CD16A on innate immune cells and EGFR, a protein widely expressed on solid tumors, to kill cancer cells. Generated by Affimeds fit-for-purpose ROCK platform, AFM24 represents a distinctive mechanism of action that uses EGFR as a docking site to engage innate immune cells for tumor cell killing through antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis.

Affimed is evaluating AFM24 in patients with advanced EGFR-expressing solid malignancies whose disease has progressed after treatment with previous anticancer therapies as monotherapy and in combinations with other cancer treatments. AFM24-101, a monotherapy, first-in-human phase 1/2a open-label, is a non-randomized, multi-center, multiple ascending dose escalation and expansion study. Additional details may be found at http://www.clinicaltrials.gov using the identifier NCT04259450. Furthermore, AFM24 is being evaluated in a phase 1/2a study in combination with Roches anti-PD-L1 checkpoint inhibitor atezolizumab (AFM24-102, NCT05109442). Affimed and NKGen Biotech have initiated a phase 1/2a study (AFM24-103), investigating AFM24 in combination with SNK01, NKGen Biotechs NK cell product (NCT05099549).

About Affimed N.V.

Affimed (Nasdaq: AFMD) is a clinical-stage immuno-oncology company committed to give patients back their innate ability to fight cancer by actualizing the untapped potential of the innate immune system. The companys proprietary ROCK platform enables a tumor-targeted approach to recognize and kill a range of hematologic and solid tumors, enabling a broad pipeline of wholly-owned and partnered single agent and combination therapy programs. The ROCK platform predictably generates customized innate cell engager (ICE) molecules, which use patients immune cells to destroy tumor cells. This innovative approach enabled Affimed to become the first company with a clinical-stage ICE. Headquartered in Heidelberg, Germany, with offices in New York, NY, Affimed is led by an experienced team of biotechnology and pharmaceutical leaders united by a bold vision to stop cancer from ever derailing patients lives. For more about the companys people, pipeline and partners, please visit: http://www.affimed.com.

Investor Relations Contact

Alexander FudukidisDirector, Investor RelationsE-Mail: a.fudukidis@affimed.comTel.: +1 (917) 436-8102

Media Contact

Mary Beth Sandin Vice President, Marketing and CommunicationsE-Mail: m.sandin@affimed.com Tel.: +1 (484) 888-8195

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CORRECTING and REPLACING -- Affimed NV - GlobeNewswire

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