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Health center to provide gender-affirming care on campus by fall 2022 – The Collegian – The Collegian

Posted: April 6, 2022 at 2:41 am

Students and staff have advocated for over a year for the Student Health and Counseling Center (SHCC) to offer gender-affirming care (GAC) for transgender and nonbinary students. In response to their efforts, the SHCC now plans to incorporate GAC by fall 2022.

Jordan Fitzpatrick, a first-year graduate student in the sasters in social work program, planned an informational meeting for students via Zoom on April 1 in response to students and staff being met with reluctance or refusal by the health center to incorporate GAC.

GAC includes counseling support as well as medical support, such as providing hormone replacement therapy (HRT) on campus, for transgender and nonbinary students.

Fitzpatrick was expecting to involve students in advocating for the inclusion of GAC. Instead, he was able to present attendees with the SHCCs plan for GAC, with both counseling and medical support, including having an experienced physician [to] provide HRT services on-site, according to the plan.

The plan states its primary goal is to provide a sustainable programmatic operational plan supporting our students with gender-affirming care.

The plan includes counseling and psychological services, medical services, an improved website with updated resources, a GAC care group, additional SHCC positions to hire for and a Cross-Cultural and Gender Center (CCGC) student liaison, all by the start of the fall 2022 term.

Fitzpatrick, who also uses the pronoun they, explained that offering HRT on campus rather than being referred out is particularly important due to the limited options for GAC within the Central Valley.

Most people have to travel outside the Central Valley in order to receive basic care. Often, when transgender and gender nonconforming people do seek medical care in the Central Valley, they face doctors who are not informed on how to care for [them], or refuse care, or are outright hostile to [them], they said.

Fitzpatrick noted that these students, who paid for services at the health center as part of their tuition just like other students, should be able to receive this care and not be denied hormones due to gender.

During the meeting, Fobear explained that the refusal to offer GAC, and in particular HRT, is an equity issue.

Fobear noted that currently two women can go to the SHCC, one cisgender and one transgender, and one can be given hormonal treatment in the form of birth control, and one can be denied hormonal treatment in the form of HRT, and called this an instance of discrimination.

Its really important that we make sure that this actually happens and we hold them accountable, and that we have a way to make sure that it stays in place, Fitzpatrick said.

Fobear and Fitzpatrick assured attendees that despite the promise to incorporate GAC, there was more to be done, and that the process to get there hadnt been simple, either.

The need to begin offering GAC care arose about a year and a half ago before the meeting, according to Fobear, when John Beynon from the English department spoke to the Fresno State LGBT+ Allies Network on the need for and the possibility of providing GAC at the SHCC, which he had seen being done at other CSU campuses, such as Chico State and Cal Poly.

Concerned campus members formed a GAC subcommittee focused on bringing GAC to campus, and have been in talks for the last year on how to begin offering this care to students as well as protecting transgender and nonbinary students seeking GAC from discrimination, Fobear said.

[The talks] intensified within the past four months, where the biggest sticking issue was about providing HRT on campus. There seem to have been a lot of maybe reticence, maybe roadblocks, but basically no sort of commitment into providing this, Fobear said.

Recent talks, which Fobear described as intense, showed no sign of improvement. Despite initially hesitating to involve students out of reluctance to stress out transgender and nonbinary students, Fobear said this is when she and Fitzpatrick decided to reach out.

Fitzpatrick sent out the invite to the first informational meeting for the student collective, but on March 31, the SHCC sent in its care model before the meeting even took place.

Still, due to the struggles to get to that point, attendees stressed the need to ensure accountability by the health center.

Fobear encouraged attendees to continue advocating for the need for GAC on campus and to stay involved in the process, attributing the current successes to student and facultys efforts and attention.

The logistics of ensuring accountability and making the GAC sustainable were discussed at the end of the meeting, and will continue to be specified in any upcoming meetings.

Other topics pertaining to LGBTQ+ students were discussed during the meeting, such as the possibility of turning the University Student Union into an LGBTQ+ center once the Resnick Student Union (RSU) opens. Concerns raised about gender neutral bathrooms in the RSU were settled by ASI President DAungullique Jackson, who also attendes and assured other attendess the gender neutral bathrooms would be available.

Students who are interested in attending future meetings and participating in these discussions can email Fitzpatrick at gac4fresnostate@gmail.com to be added to the mailing list and be alerted when future announcements are made.

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How to ease joint pain during the menopause – Patient.info

Posted: April 6, 2022 at 2:41 am

What causes menopause joint pain?

It may be a natural part of the female ageing process, but menopause can bring discomfort and pain in a number of ways. Learning how to manage your symptoms can make a big difference in your quality of life during this period.

From hot flushes and vaginal dryness to disturbed sleep and anxiety, there are lots of possible symptoms that may make daily activities more challenging. These noticeable changes reflect the significant change that's taking place in your body, as your sex hormone levels fluctuate and cause your ovaries to lose their reproductive function.

Ann Clare, a physiotherapist for MBST UK, explains how these changes can lead to menopause joint pain: "Oestrogen, the hormone that plays a key role in regulating your menstrual cycle, helps to decrease inflammation and keep the joints lubricated. During the menopause and perimenopause, oestrogen levels decrease and as a result, some women experience joint pain."

"Recent studies have suggested that a decrease in oestrogen not only reduces natural bone density but also affects muscle strength and tendon health. In turn, this may result in longer injury recovery times," says Kirsty Lee, senior physiotherapist and pelvic health lead at Ascenti.

Menopause joint pain can affect joints all over your body and can also result in longstanding injuries becoming more painful.

According to Lee, menopause joint pain most commonly affects the following areas:

"As oestrogen continues to decrease, joints can become more inflamed and painful, resulting in an increased risk of osteoporosis (thinning of the bone) and osteoarthritis (inflammation of the joints) developing," she adds.

When it could be osteoarthritis

Osteoarthritis is more likely to occur in people over 50 years, around the same time that many women start menopause. While joint pain and stiffness around the time of menopause doesn't always indicate osteoarthritis, it can be a symptom. Osteoarthritis joint pain is more likely to occur in the knees, hips, lower spine, fingers, and thumbs.

When it could be osteoporosis

Being over 40 and going through menopause increases your chances of rapid bone loss, which may lead to osteoporosis. Unlike menopause joint pain and osteoarthritis, you usually won't feel pain unless you break a bone. Your doctor may wish to test you for osteoporosis if you are menopausal and have had a bone breakage from a minor injury.

Back pain, and particularly lower back pain, can become a problem for many women as they go through menopause. In fact, one survey of 5,325 women found that postmenopausal women were twice as likely to report lower back pain as premenopausal women.

Your spine is made up of multiple joints, including facet joints that allow movement in your back. Decreased oestrogen results in greater inflammation of these joints and also causes your spinal (intervertebral) discs to wear down.

Menopause joint pain of the knees is also very common. This may not be surprising, given that your knee is one of your largest joints, connecting and supporting your thighbone (femur), kneecap (patella), shinbone (tibia), and calf bone (fibula). Your knees are subject to a great deal of pressure and wear throughout your life as they support a large portion of your weight.

The good news is, there are both medical and non-medical forms of pain management that are proven to significantly reduce menopause joint pain. This can start with simple routines in the home.

Home treatments include:

Your diet is hugely important in both preventing and managing health issues, and menopause joint pain is no different. "Try to eat a healthy, balanced diet that is high in fibre with lots of fruit, vegetables and wholegrain foods," advises Clare.

Eating the right foods can improve a range of menopause symptoms. The key is to consume lots of nutrients from various food groups.

The foods that most directly impact joint and bone health include:

"You should also try to avoid large quantities of saturated fats. If you are suffering from hot flushes, try to make a note of what seems to bring them on - for some people it is alcohol and for others caffeine," adds Clare.

If you experience menopause joint pain, you may be tempted to limit your movements. It may feel counter-intuitive at first, but the experts recommend staying as physically active as possible.

Lee says: "Move! Motion is lotion, and if this is managed and progressed slowly it can be an effective tool for pain management."

Why: "Unfortunately, weight gain is also a common side effect of menopause, and increased weight can have a detrimental effect on joint and muscle pain due to increased load. Therefore, weight management is a key part of managing joint pain."

What: "There are lots of forms of exercise that can help with pain as well as other menopause symptoms. An effective 'menopause friendly' programme should consist of endurance, strength/resistance, and balance exercises."

Clare says: "It is best to be as active as possible and most of all enjoy your sports."

Why: "Weight-bearing exercises will strengthen your musculoskeletal system which will help to alleviate joint aches and pains, protect brittle bones, and may prevent osteoporosis."

What:

Ivana Daniell, movement and posture expert, says: "The right choice of exercise programme can be of great support during the time of menopause, both physically and mentally. Be aware of not pushing your body too hard, especially during this delicate hormonal transition."

Why: "When the female body is pushed too hard, it goes into adrenal stress and this creates havoc in the incredibly engineered yet delicate hormonal balance."

What: "Quality of movement versus quantity is paramount. Regular and consistent exercise is better than sporadic visits to the gym that make you exhausted. Choose activities that uplift your mood and practise 2-3 times per week in addition to your daily 30-40 minute walk."

You may also use over-the-counter medicines to help reduce inflammation and painful joints. These include common painkillers and anti-inflammatory gels and medication. Your pharmacist will be able to advise.

It should also be noted that hormone replacement therapy (HRT) is widely accepted as the most effective method for managing the symptoms of menopause. By restoring the oestrogen levels you lose during menopause, there is strong evidence that HRT can ease menopause joint pain alongside a whole host of other symptoms.

There are also several menopause herbal remedies and supplements on the market. Biomedical gerontologist Dr Marios Kyriazis says that supplementation should be used alongside - and not as a substitute for - healthy lifestyle changes:

"The most effective lifestyle changes include switching to an anti-inflammatory diet, incorporating light to moderate physical activity, practising breathing and relaxation exercises on a daily basis, and improving sleep patterns. Under these conditions, herbal blends and anti-inflammatory supplements work best."

Kyriazis recommends supplementing curcumin, the active ingredient in turmeric.

Curcumin may:

"By fermenting turmeric, its curcumin content becomes more bio-available at a smaller dose and is gentler on the stomach than the usual raw turmeric with black pepper that is generally recommended," he adds.

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What’s behind the trend of women posting make-up free photos on social media? – Fox News

Posted: April 6, 2022 at 2:41 am

NEWYou can now listen to Fox News articles!

What do Michelle Pfeiffer, Tyra Banks, Jennifer Aniston, Jennifer Lopez and Helen Mirren have in common?

Social media platforms dont just harm teenagers, but can be harmful to women as they age, so these women are fighting back with make-up selfies to embrace their age, according to a recent Wall Street Journalreport.

"Were also bombarded by images on our phones all the timethis five years ago, this 10 years ago," New York psychiatrist Dr. Samantha Boardman, noting, " its a reminder of the passage of time and how we do look different."

She said we should be paying more attention how social media affects women as they get older, because it makes older women feel as bad as teenagers, especially when the way a woman looks doesnt match how she is feeling.

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"I have a craving to see real faces of my age, so I dont feel so alone in aging," said model Paulina Porizkova, who is56.

MIAMI, FL - MAY 11: Paulina Porizkova attends the Sports Illustrated Swimsuit Celebrates 2019 Issue Launch at Myn-Tu on May 11, 2019, in Miami, Florida. ((Photo by John Parra/Getty Images for Sports Illustrated))

Middle age is often a time of high stress for women, because many are trying to balance careers, raise children and also care for aging parents, according to theJournal.

As more older women begin to embrace their natural look, posting make-up selfies can be empowering.

"Its satisfying to feel connected and not so alone in how you look, so I think there is a generosity in that when its authentic," saidBoardman.

She cautioned the natural look might be staged at times with products, treatments and injectables that contribute to that look, so when sometimes celebrities post the "natural" hashtag, it might be supported by ring lights, secret makeup and even a filter, per the paper.

"Often were barraged with images that we dont even know are touched up," New Yorkbased psychiatrist and dermatologist Dr. Amy Wechsler told thepaper.

Some beauty brands, like Milk, Dove and Olay, are supporting this trend, using real photos that are not retouched across a wide spectrum of ages to showcase womens beauty at their stage inlife.

But make-up free selfies arent the only remedy middle-age women are using to take care of their mental health many are resorting to antidepressants, according to the Wall StreetJournal.

Tyra Banks recalled once holding her dress together while filming 'Dancing with the Stars.' (Getty Images)

But some doctors are concerned antidepressants are being overprescribed for symptoms that may actually be attributed to menopause, which the median age in the U.S. is 51, per the newsreport.

Approximately one in five women ages 40-59 and an estimated one in four women ages 60 and older used antidepressants in the last 30 days during 2015 to 2018, compared to one in 10 for women ages 18-39, according to the most recent data from the National Center for Health Statistics.

In general women are at higher risk for depression than men, but the risk of depression is highest leading up to menopause and immediately after it. Its sometimes difficult, however, to tease out the root cause of peri-menopausal symptoms, because the imbalance of hormones during this period that are responsible for typical symptoms, such as hot flashes and night sweats, can also affect a womans mood, per theJournal.

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The most effective treatment for hot flashes and night sweats is hormone therapy with either estrogen or combined with progestogen, according to the North American Menopause Society and the American College of Obstetricians and Gynecologists.

But women are looking for alternative treatments since many are " so deathly afraid of prescribing hormones," said Dr. Stephanie Faubion, medical director of the North American Menopause Society and the director of Mayo Clinic WomensHealth.

Jennifer Aniston attends 26th Annual Screen Actors Guild Awards at The Shrine Auditorium on January 19, 2020, in Los Angeles, California. (Photo by Leon Bennett/Getty Images)

So now scientists are trying to develop anti-depressants that will target depression symptoms related to estrogen withdrawal without the side effects of hormone replacement therapy, according to Dr. Peter Schmidt, chief of the Behavioral Endocrinology branch in National Institute of Mental Health Intramural Research program.

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"While I look with wonder and awe at the women who age backwards, Id like a little more choice in representation of age. So I hope to provide a little of that for women who feel like I do, that age is coming into ones true beauty and character, and it should be celebrated, not erased," Porizkova said.

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Why so many women in middle age are on antidepressants – Mint

Posted: April 6, 2022 at 2:41 am

About one in five women ages 40 to 59 and nearly one in four women ages 60 and over used antidepressants in the last 30 days during 2015 to 2018, according to the latest data from the National Center for Health Statistics. Among women ages 18 to 39, the figure was about one in 10. Among men, 8.4% of those ages 40 to 59 and 12.8% of those 60 and older used antidepressants in the last 30 days, according to the NCHS data.

The figures are drawing increasing attention from scientists and doctors. Many are alarmed at how high depression rates were among midlife women even before the pandemic, now that the past two years have exacerbated mental-health issues for many Americans. And some doctors are also concerned that antidepressants are being overprescribed for menopausal symptoms.

In general, women have higher rates of depression than men throughout much of their lives according to scientific research. In midlife, the risk is greatest during the years leading up to menopause and right after it. The dramatic fluctuations in hormones that cause the most-commonly known symptoms of hot flashes and night sweats can wreak havoc on mood, too.

Estrogen and progesterone are fluctuating a great deal," says Lucy Hutner, a reproductive psychiatrist in New York City. Those shifts can be hard for our brain to take."

Scientists are working to understand just how hormones may drive depression, but receptors for estrogen and progesterone are found throughout the brain including in regions involving movement, cognition and mood regulation, says Hadine Joffe, a professor of psychiatry at Brigham and Womens Hospital and Harvard Medical School in Boston.

New treatments for depression in midlife women may be on the horizon. Scientists at the National Institute of Mental Health, for example, are studying a medication that acts on an estrogen receptor in the brain. The hope is that, unlike typical antidepressants, it will directly target depression symptoms related to estrogen withdrawal but without the side effects of traditional hormone therapy commonly used for menopausal symptoms, notes Peter Schmidt, chief of the Behavioral Endocrinology branch in NIMHs Intramural Research program.

Studies have found that womens risk of having an episode of major depression is two to four times higher around menopause than at other times during their lives; it is even greater for women who have a had a previous episode of depression. Menopause is defined to have occurred one year after a womans last menstrual period. The median age of menopause in the U.S. is 51.

Doctors also note that midlife is often a time of marked stress for womenand stress can increase the risk of depression. Many women are juggling careers, raising children and caring for elderly parents. You have a lot on your shoulders, and theres not a lot of room for taking time for yourself," says Dr. Hutner. Women also may be more likely to seek care for a mental-health problem than men, which may lead to higher rates of diagnosis and treatment.

Valerie DeMartin, 59 years old, says she fell into a depression in 2020. She was dealing with sleep problems, the stress of the pandemic and a move with two teenagers from the familys longtime home in California to Texas. An avid exerciser, she says she was also feeling sad to see her body changing in ways she felt she couldnt control.

I went through a life-altering move, my kids were angry with me, dealing with middle age and Covid and my body changing," says Ms. DeMartin, who works in home remodeling in Frisco, Texas.

Ms. DeMartin says she didnt seek therapy or take antidepressant medication. She says she has coped by reaching out to friends and staying busy with work. Shes also planning to try hormone-replacement therapy. Hopefully Ill have a little more energy and sleep better," she says.

Researchers at NIMH who have been following 90 women since 1988 have found that the incidence of womens midlife depression is concentrated in the two years before and after the last menstrual period, says Dr. Schmidt. The quality of womens midlife depression is distinct, too, Dr. Schmidt says, in that it often involves intense anxiety, irritability and sleep problems along with the more typical sadness and loss of pleasure in once-enjoyed activities.

Doctors speculate that antidepressant use among middle-aged women is being driven in part by the reluctance of womenand many of their physiciansin recent decades to use hormone-replacement therapy for menopausal symptoms. In 2002, a large study, the Womens Health Initiative, was stopped after women taking hormone therapy had an increased risk of breast cancer, heart attacks and strokes. Later analyses found that the risks were largely concentrated among women who were older when they started hormone therapy. For women in their 50s, hormone therapy actually reduced the risk of heart disease and death from any cause.

Hormone therapy, either estrogen alone or combined with a progestogen, is the most effective treatment for hot flashes and night sweats, according to the North American Menopause Society and the American College of Obstetricians and Gynecologists. Some research has found that it can also improve mood.

Still, many women and doctors are looking for alternatives. People are so deathly afraid of prescribing hormones," says Stephanie Faubion, medical director of the North American Menopause Society and the director of Mayo Clinic Womens Health. A lot of women, unfortunately, who are going to their doctors because of hot flashes and night sweats are getting slapped on antidepressants."

Research has shown that some antidepressants can ease hot flashes and night sweats. But Dr. Faubion says they are much less effective than hormones. The even higher rates of antidepressant use among women 60 and over may partly result from women being put on them when theyre younger, during this earlier period of mental-health vulnerability, and then being left on them by default, says Dr. Hutner.

This story has been published from a wire agency feed without modifications to the text

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Legislature needs to stop its attacks on the LGBTQ community – messenger-inquirer

Posted: April 6, 2022 at 2:41 am

Im writing in response to Senate Bill 83, which was recently passed in the Kentucky legislature. Its referred to as the transgender sports ban. This bill is not necessary and a waste of time.

The bill, since it passed and is now waiting for Gov. Andy Beshears signature, effectively bans trans women from playing on the sports teams they want to play on. What Republicans fail to recognize is the fact that scientific studies have been done that show that transgender women hold zero physical advantage over cisgender women.

In fact, a year after being on hormone replacement therapy, trans women have the same strength as their cisgender female counterparts.

What the state legislature should focus on instead of passing LGBTQ discrimination laws is the child abuse rate. Currently, Kentucky ranks fifth in the country in reported child abuse.

The legislature needs to stop the hate of the LGBTQ community and start representing all Kentuckians equally.

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Below the Belt: Sexual Dysfunction Overlooked in Women With Diabetes – Medscape

Posted: April 6, 2022 at 2:41 am

Among patients with diabetes, women are just as likely as men to suffer from sexual dysfunction, but their issues are overlooked, with the narrative focusing mainly on the impact of this issue on men, say experts.

Women with diabetes can experience reduced sexual desire, painful sex, reduced lubrication, and sexual distress, increasing the risk of depression, and such issues often go unnoticed despite treatments being available, said Kirsty Winkley, PhD, diabetes nurse and health psychologist, King's College London, UK.

There is also the "embarrassment factor" on the side of both the healthcare professional and the patient, she said in a session she chaired at the Diabetes UK Professional Conference 2022 this week. Many women with diabetes "wouldn't necessarily know" that their sexual dysfunction "is related to their diabetes," she told Medscape Medical News.

For women, sexual health conversations are "often about contraception and pregnancy," as well as menstrual disorders, genital infections, and hormone replacement therapy. "As healthcare professionals, you're trained to focus on those things, and you're not really considering there might be sexual dysfunction. If women aren't aware that it's related to diabetes, you've got the perfect situation where it goes under the radar."

However, co-chair Debbie Cooke, PhD, health psychologist at the University of Surrey in Guildford, explained that having psychotherapy embedded within the diabetes team and "integrated throughout the whole service" means that the problem can be identifiedand treatment offered.

The issue is that such integration is "very uncommon" and access needs to be improved, Cooke told Medscape Medical News.

Jacqueline Fosbury, psychotherapy lead at Diabetes Care for You, Sussex Community NHS Foundation Trust, said that "intimate activity is clearly beneficial for emotional and physical health," as it is associated with increased oxytocin release, the burning of calories, better immunity, and improved sleep.

Sexual dysfunction is common in people with diabetes, she noted. Poor glycemic control can "damage" blood vessels and nerves, causing reduced blood flow and loss of sensation in sexual organs.

A recent study led by Belgian researchers found that among more than 750 adults with diabetes 36% of men and 33% of women reported sexual dysfunction.

Sexual dysfunction was more common in women with type 1 diabetes, at 36%, compared with 26% for those with type 2 diabetes. The most commonly reported issues were decreased sexual desire, lubrication problems, orgasmic dysfunction, and pain. Body image problems and fear of hypoglycemia also affectsexuality and intimacy, leading to "sexual distress."

Moreover, Fosbury said female sexual dysfunction has been identified as a "major predictor" of depression, she added, which in turn reduces libido.

Treatments for women can include lubricants, local estrogen, and medications that are prescribed off-label such as sildenafil. The same is true of testosterone therapy, which can be used to boost libido.

Next, Trudy Hannington, a psychosexual therapist with Leger Clinic, Doncaster, UK, talked about how to use an integrated approach to address sexuality overall in people with diabetes.

She said this should be seen in a biopsychosocial context, with emphasis on the couple, on sensation and communication, and sexual growth, as well as changes in daily routines.

There should be a move away from "penetrative sex," Hannington said, with the goal being "enjoyment, not orgasm." Pleasure should be facilitated and the opportunities for "performance pressure and/or anxiety" reduced.

She discussed the case of Marie, a 27-year-old woman with type 1 diabetes who had been referred with painful sex and vaginal dryness. Marie had "never experienced orgasm," despite being in a same-sex relationship with Emily.

Marie's treatment involved a sexual growth program, to which Emily was invited, as well as recommendations to use lubricants, vibrators, and to try sildenafil.

Fosbury reiterated that, in men, sexual dysfunction is "readily identified as a complication of diabetes" and is described as "traumatic" and "crucial to well-being." It is also seen as "easy to treat" with medication, such as that for erectile dysfunction.

It is therefore is crucial to talk to women with diabetes about possible sexual dysfunction, and the scene must be set before the appointment to explain that the subject will be broached. In addition, handouts and leaflets should be available for patients in the clinic so they can read about female sexual health and to lower the stigma around discussing it.

"Cultural stereotypes diminish the importance of female sexuality and prevent us from providing equal consideration to the sexual difficulties of our patients," she concluded.

No funding declared. No relevant financial relationships declared.

Diabetes UK Professional Conference 2022. Session: Sexual healing in the diabetes clinic. Presented March 28, 2022.

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Symptoms, survival and treatment. What do we know about the disease attributed to Putin? – Persia Digest

Posted: April 6, 2022 at 2:41 am

Self Russian President Vladimir Putin really suffer from a thyroid cancerAs the independent Russian newspaper Proekt speculates, this is not yet an established fact. At the moment, we only know that endocrinologist Yevgeny Silivanov, from the Central Clinical Hospital in Moscow, has accompanied the Russian president on his trips at least 35 times in the past four years. Meanwhile, the Kremlin is quick to deny. In fact, if the news is confirmed, it means that President Putin has already undergone an operation and, accordingly, is receiving thyroid hormone replacement therapy.

The only treatment for thyroid tumors, in fact, is surgery only, explains Rocco Bellanton, director of the Center for Endocrine and Metabolic Surgery at Gemelli Polyclinic in Rome, the Italian center with the largest number of thyroid cancer treatments: Here are more than two Over a thousand thyroid gland operations are performed annually, of which more than 500 are malignant. There are different types of thyroid cancer fortunately, in most cases, the tumor, even if it is malignant, has an excellent prognosis, that is, it cures in more than 90 percent of cases. However, there are some types of tumors that are Significantly rare and electrolytically unfavorable.

According to the Italian Society of Medical Oncology (AIOM), thyroid cancer is the most common tumor of the endocrine system (90%) and accounts for 3.8% of all tumors. In 2016, about 15,300 new cases were diagnosed in Italy, 4 percent of all malignancies, and 3 quarters of cases in women. In general explains Bellanton it manifests itself as a lump in the neck or, in a more advanced stage, with difficulty speaking, breathing and swallowing. However, it is usually asymptomatic, and therefore we go to the doctor when the tumor is in an advanced stage. In fact, the tests to diagnose it are quite trivial explains the Gemelli expert since it is a very superficial organ, located at the base of the neck, a visit and then an ultrasound examination above all is sufficient to allow us to diagnose tumors a few millimeters in size.

Once identified, there is no other method than the surgical method. In initial cases it is sufficient to remove half of the thyroid gland, but in more advanced cases, the entire organ is removed. Its hard to know if you have thyroid cancer when its asymptomatic. However, there are known risk factors that should lead to regular checkups. In the meantime Pelanton identifies the greatest danger occurs when you are close to radiation. Indeed, with the Chernobyl crisis there was a frightening increase in thyroid cancer throughout the region of Ukraine, Belarus and Russia. To reach an early diagnosis, we recommend screening for all people who have had thyroid problems, those who have been in radioactive areas, or those who have family members with the same problem. Today, at Gemelli, they are able to remove malignancies that reach Its size is three or 4 mm. This is a surgery that requires a hospital stay of two or three days confirms Bellanton and if it is done by experts it does not have any postoperative problems. The risks are usually associated with the proximity of the thyroid gland to the vocal cords. Thus, a significant decrease in the voice can occur in the postoperative phase. On the plus side, there is no need for another invasive treatment after surgery.

This is not a cancer that requires chemotherapy. There is a treatment called Radiometabolic, that is, radioactive iodine is taken to destroy any cells that remain even after surgery. We repeat that it can be cured in more than 90 percent of cases. After surgery, a tablet must be taken, but you have to Finding the right dose, otherwise the patient is at risk of swelling and gaining weight. However, there are thyroid cancers that do not escape. So far explains Bellanton we have indicated the most common form of thyroid cancer. But then there is a significantly bad form, It quickly leads to an enlarged neck, voice and breathing disorders. It is a rare form, affecting no more than 2 percent of cases. It is a type of tumor that requires chemotherapy, radiotherapy, but the prognosis is quite poor.

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This Mornings Lisa Snowdon breaks down in tears as she gives fans an update on her rollercoaster healt… – The Sun

Posted: April 6, 2022 at 2:41 am

THIS Morning's Lisa Snowdon broke down in tears as she told fans about her 'rollercoaster' experience of going through menopause.

The 50-year-old bravely opened up about her health struggles in a recent social media post.

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And in a bid to bust taboos surrounding menopause, she joined forces with her doctor, Naomi Potterfor an Instagram live on the subject.

The model told fans that she wanted to be "honest and open" about her journey.

Lisa, who has started hormone replacement therapy (HRT) to help her, wanted to make it clear to her followers that it's normal to feel like you're struggling.

During her chat with Dr Potter Lisa struggled to keep it together as she said: "I'm lucky that I have you as my doctor, I'm lucky that I've got George who is so supportive.

"I just want to reach out and say that it is really hard.

"I know so many people that are struggling and I've been so open on this platform and also very upbeat..."

Lisa regularly shares how she's feeling with fans on Instagram and explained how useful she has found HRT.

The star captioned the post: "The madness of the menopause continues. Its ok to not be ok thats the moral of this weeks Midweek Menopause Madness.

"Thank you for all your continued support.

"Its a rollercoaster and sometimes depending on lifestyle changes, stress, world events, illness, life in general the darkness and sadness hits me/us.

"In times like these its good to share, its good to talk, its also good to reevaluate what might be the triggers, looking at diet, and also making sure we move!"

Many fans rushed to the comments section to share their love and support.

What is the menopause and when does it usually start?

Menopause is a natural part of ageing, which usually happens when a woman is between the age of 45 and 55.

In the UK, the average age for a woman to go through menopause is 51.

It occurs when oestrogen levels in the body start to decline.

During this time periods become less frequent or they can suddenly stop, and after menopause occurs women will be unable to become pregnant naturally.

Around one in 100 women experience menopause before the age of 40, and this is known as premature ovarian insufficiency or premature menopause.

Many celebrities have spoken out about their own experiences, including Lisa Snowdon, Davina McCall, Michelle Heaton and Zoe Hardman.

What are the symptoms?

Menopausal symptoms can start months or years before your periods stop, and can last until four years or longer after your last period.

Symptoms include:

One wrote: "Your honesty has made me feel less alone, thank you Parallel journey and the lows are tough. Sending hugs."

Another said: "Lisa, I think you are truly amazing, your raw, open honesty is just the best and helps so many people. Keep shining and most importantly keep being you! Xx."

A third added: "Totally understand Lisa you could be talking about me .. found this month particularly hard! Sending love ."

A fourth simply chimed in: "I am so so grateful you shared this."

Lisa went through menopause early, at 44-years-old.

Last year she revealed that she was cruelly robbed of the opportunity to start a family with her "brilliant" fiance George Smart, 44, when her menopause began five years ago.

Though its still possible for some women to have a baby in perimenopause, I knew my partner and I probably wouldnt be able to have a biological child now," she told The Sun for the Fabulous Menopause Matterscampaign.

Wed discussed it in the past, but hadnt started trying, so I knew wed have to explore other options in the future if we did want to become parents.

"George was brilliant about it and told me we could look into alternative ways in the future.It was a lot to come to terms with.

Speaking about when she was told, Lisa added: "In 2017, aged 44, I began to really pile on weight around 3st over the next year or so and I was having brain fog, anxiety, and real fits of rage, the model reveals.

In 2018, I went to the doctor for blood tests, which was when I got the bombshell that I was perimenopausal. It all finally made sense, but it was hard to process.

3

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This Mornings Lisa Snowdon breaks down in tears as she gives fans an update on her rollercoaster healt... - The Sun

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Eli Lilly and Company Launches the Lilly Institute for …

Posted: April 6, 2022 at 2:40 am

Posted on 02/22/2022

Eli Lilly and Company (NYSE: LLY) revealed the creation of the Lilly Institute for Genetic Medicine and an investment of approximately US$ 700 million to establish a state-of-the-art facility at a new site in the Boston Seaport. This investment part of the companys strategy to advance RNA based therapeutics builds on the 2020 acquisition and rapid expansion of Prevail Therapeutics, a gene therapy company based in New York City.

Through the work of the Institute, Lilly intends to fuel the development of genetic medicines, which already account for more than 20% of Lillys diabetes, immunology, and central nervous system research portfolio. Within 5 years, Lilly projects the Boston site will grow from 120 to more than 250 research biologists, chemists, data scientists and other experts in genetic medicine, while the New York site will grow to include up to 200 scientists all employed by Lilly.edicines that make life better for people around the world.

The Institute will be headquartered in 334,000 sq. ft. of leased space in a 12-story building, developed and operated by Alexandria Real Estate Equities, Inc., in the rapidly expanding Seaport district of Boston. Occupancy of the new site is scheduled for 2024.

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Could Weekly, Not Daily Prednisone Represent A New Approach to Obesity Therapy? – Genetic Engineering & Biotechnology News

Posted: April 6, 2022 at 2:40 am

Its recognized that daily prednisone promotes obesity, but a new preclinical study by Northwestern Medicine researchers has shown that once-weekly prednisone has very different results, promoting nutrient uptake into muscles and improving lean body mass. The teams research showed that obese mice fed a high-fat diet (HFD) and receivingthe glucocorticoid steroid prednisone just once per week had improved exercise endurance, became stronger, lost weight, and demonstrated increased lean body mass. The treated animals also exhibited increased muscle metabolism, and increased levels of adiponectin, a fat-derived hormone that appears to play an important role inprotecting against diabetes and insulin resistance.

Daily prednisone is known to promote obesity and even metabolic syndromea disorder with elevated blood lipids and blood sugar and weight gain, said Elizabeth McNally, MD, PhD, director of the Center for Genetic Medicine at Northwestern University Feinberg School of Medicine. So, these results, in which we intermittently pulse the animals with once-weekly prednisone, are strikingly different. Obesity is a major problem, and the idea that once-weekly prednisone could promote nutrient uptake into muscle might be an approach to treating obesity.

McNally and colleagues reported on their findings in the Journal of Experimental Medicine, in a paper titled, Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin. In their paper the researchers concluded, Our study demonstrates that intermittent glucocorticoids produce healthful metabolic remodeling in diet-induced obesity. McNally is a Northwestern Medicine physician and the Elizabeth J. Ward professor of genetic medicine.

Fatmuscle communication regulates metabolism and involves circulating signals like adiponectin, the author explained. Modulation of this cross-talk could benefit muscle bioenergetics and exercise tolerance in conditions like obesity. Many patients take prednisone daily for different immune conditions. Known side effects of daily prednisone include weight gain and even muscle atrophy with weakness. The authors noted, Glucocorticoid steroids such as prednisone are widely used immune suppressants and their chronic daily intake promotes metabolic stress and obesity.

The team had been interested in finding out whether patients can get the same immune benefit with intermittent prednisone dosing, which could be much more beneficial to the muscle. In previously published research, McNallys team discovered that giving prednisone intermittently was helpful for muscular dystrophy, and they demonstrated that once-weekly prednisone improved strength.The group also recently reported findingsfrom a pilot clinical trial in individuals with muscular dystrophy, in which one weekly dose of prednisone improved lean mass.

The newly reported research in mice with dietary obesity showed that intermittent once-weekly prednisone increased adiponectin levels and improved exercise tolerance and energy expenditure. The effects were dependent on adiponectin, as adiponectin gene knockout (Adipoq-KO) mice failed to benefit from weekly prednisone therapy. Intermittent prednisone promoted muscle metabolism and exercise tolerance through adiponectin, the team commented, and added, treatment failed to improve adiposity, exercise tolerance, and insulin tolerance with HFD in Adipoq-KO mice.

The scientists also showed that the benefits of once-weekly prednisone therapy also extended to mice that were already obese from eating a high-fat diet, with treated animals experiencing increased strength, running capacity, and lower blood glucose. Opposite to daily dosing, intermittent prednisone blunted weight accrual and improved strength, treadmill endurance, and glucose homeostasis in mice with pre-established obesity, the investigators stated. The studies confirmed that the favorable metabolic effects of prednisone were specific to the intermittent dosing even in mice already obese before treatment.

Most of what has previously been known about steroids such as prednisone has resulted from studies investigating the effects of taking prednisone every day. We see a very different outcome when it is taken once a week, said McNally. We need to fine-tune dosing to figure out the right amount to make this work in humans, but knowing adiponectin might be one marker could provide a hint at determining what the right human dose is.

McNally described the weekly dose as a bolus, or spike, of nutrients going into your muscle. She said, We think there is something special about promoting this spike of nutrients into muscle intermittently, and that it may be an efficient way to improve lean body mass.

Corresponding author, Mattia Quattrocelli, PhD, added, What is exciting to me about this work is the finding that a simple change in the dosing frequency can transform glucocorticoid drugs from inducers to preventers of obesity. Chronic once-daily intake of these drugs is known to promote obesity. Here we show that dosing the same type of drug intermittentlyin this case, once weeklyreverses this effect, promotes muscle metabolism and energy expenditure, and curtails the metabolic stress induced by a fat-rich diet. Quattrocelli, who initiated the research while at Northwestern, is now assistant professor at Cincinnati Childrens Hospital Medical Center and department of pediatrics at the University of Cincinnati.

People have different responses to prednisone dosing so McNally wants to determine which biomarkers are most critical to mark having a beneficial response to prednisone. If we can determine how to choose the right dose of prednisone that minimizes atrophy factors and maximizes positive markers like adiponectin, then we can really personalize the dosing of prednisone, she said.

The group also recently showed that weekly prednisone uses strikingly different molecular pathways to strengthening the muscle in male versus female mice, based on a recently published studyby Isabella Salamone, a graduate student in McNallys lab.

The benefits of weekly prednisone are linked to circadian rhythms, reported another recent study from Northwestern and University of Cincinnati. Human cortisol and steroid levels spike early in the morning before you wake up.If you dont give the drug at the right time of day, you dont get the response,Quattrocellisaid. In mice, we obtained good effects with intermittent prednisone in muscle mass and function when we dose them at the beginning of their daytime. Mice have a circadian rhythm inverted to us, as they generally sleep during the daytime and are active at night. This could mean that the optimal dosing time for humans during the day could be in the late afternoon/early evening, but this needs to be appropriately tested.

McNally remains cautious about making inferences on the potential clinical applications of intermittent prednisone. These studies were done in mice, she acknowledged. However, if these same pathways hold true in humans, then once-weekly prednisone could benefit obesity.

She further noted, While we are encouraged by the pilot study in humans with muscular dystrophy, mouse muscles have more fast-twitch fibers than humans, and slow-twitch muscle could be different. More studies are needed to try to better understand whether these same mechanisms work in human muscles.Nevertheless, the authors stated in their newly released paper, In conclusion, our study reported that intermittent prednisone promoted a virtuous fat-muscle communication through adiponectin. These findings pave the way for adjuvant drug strategies to restore adiponectin sensitivity and exercise tolerance in conditions of metabolic stress.

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