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3D Cell Culture Market are Predicted to Increase at a Positive CAGR Of 9.8% from 2022 to 2031 – Comprehensive Research Report by FMI – BioSpace

Posted: April 6, 2022 at 1:53 am

DUBAI, United Arab Emirates, The global 3D cell culture market stands at a net worth of US$ 1.15 Bn in 2022, and is predicted to surge ahead at a CAGR of 9.8% over the forecast period to attain a valuation of US$ 2.67 Bn by 2031.

3D cell culture is a suitable alternative in translational and regenerative medicine since its represents a new, advanced, and robust platform for the investigation of complex biological procedures. 3D cell culture is projected to extend to various sectors of scientific research.

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The 3D cell culture market revenues surpassed US$ 778 million in 2018, as per a new FMI study. The market is estimated to grow at 7.8% y-o-y in 2019; key factors responsible for the projected market growth include,

While 2D cell culture revolutionized the research efforts in stem cells, tissue engineering, and molecular biology, 3D cell culture has pushed the boundaries of traditional 2D cell culture technique with functional superiority. As the R&D efforts continue to rise in a bid to investigate the cause of different diseases and improve human health, 3D cell culture is set to remain a highly sought-after technique in the coming years, says FMI.

The FMI study finds that scaffold-based 3D cell culture techniques are highly preferred over scaffold-free 3D cell culture. Owing to the significant adoption of scaffold-based 3D cell culture, the study finds that this technique garnered over 81% of the global market revenues.

Scaffold-based 3D cell culture techniques deliver researchers with additional functional operations in terms of material natural or synthetic and different mechanical properties.

The technique uses either hydrogel-based support or polymeric hard material based support. Both types of supports find equivalent penetration in terms of application, however revenues garnered from polymeric hard material based support are higher.

According to the study, revenues of polymeric hard material based support held over half the scaffold-based 3D cell culture technique revenues in 2018 and the trend is expected to continue in the future.

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Application of 3D Cell Culture in Cancer Research Prominent

The FMI study estimates that 3D cell culture application in cancer research accounted for over 31% of the 3D cell culture market revenues in 2018. Cell culture is an integral part of cancer drug discovery practices. Greater strides are underway in the field to precisely characterize the diseases and develop advanced tumor cell lines using 3D cell culture techniques.

2D culture lines are considered as a standard for in vitro pre-clinical cancer treatment screening. However, more recently, the field is turning to 3D cell culture techniques to implement an ideal experimental model that mimics the human body environment to its best.

Stem cell technology is another lucrative field for 3D cell culture market. According to the FMI study, application in stem cell technology accounted for over one-fourth of the 3D cell culture market revenues in 2018. While 2D cell culture posed challenges of scalability in stem cell technology, apart from a few challenges, 3D cell culture has provided greater density and multi-fold expansion of the culture system in stem cell technology. Other fields that utilize 3D cell culture techniques are tissue regeneration, regenerative medicine, and drug discovery.

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Biotechnology and Pharmaceutical Industries - Prominent End-Users

The study reveals that the biotechnology and pharmaceutical industries were accounted for over one-fifth of the global 3D cell culture market revenues in 2018. Buoyancy in the biotechnology and pharmaceutical industries can be profitable for the 3D cell culture market in the coming years and over 9% growth is projected in 2019 over 2019.

Academic research institutes are the second prominent end-users of 3D cell cultures wherein they accounted for over one-fourth of the global 3d cell culture revenues in 2018. Government funding in cancer research projects carried out at academic institutes and organizations has increased significantly, thereby supporting the investments in advanced technologies including 3D cell culture techniques.

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Future Market Insights (FMI) is a leading provider of market intelligence and consulting services, serving clients in over 150 countries. FMI is headquartered in Dubai, and has delivery centers in the UK, U.S. and India. FMI's latest market research reports and industry analysis help businesses navigate challenges and make critical decisions with confidence and clarity amidst breakneck competition. Our customized and syndicated market research reports deliver actionable insights that drive sustainable growth. A team of expert-led analysts at FMI continuously tracks emerging trends and events in a broad range of industries to ensure that our clients prepare for the evolving needs of their consumers.

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3D Cell Culture Market are Predicted to Increase at a Positive CAGR Of 9.8% from 2022 to 2031 - Comprehensive Research Report by FMI - BioSpace

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Regenerative Medicine Market Size 2022 Share, Growth By Top Company, Business Opportunity, Regional Analysis, Application, Driver, Trends &…

Posted: April 6, 2022 at 1:53 am

Kenneth Research, in its repository of market research reports, has recently added a report titledRegenerative Medicine Market, that emphasizes on the recent market trends and opportunities available for the growth of the market for the forecast period 2022-2031. The growth of the Regenerative Medicine Market can be attributed to the increasing health spending by nations across the globe, and for the rapid innovations observed in the medical sector. According to a report by the World Health Organization (WHO), the total health spending is growing with an annual average rate of 6% in the low- and middle-income nations, and close to 4% in the high-income countries. Further, in the year 2016, the expenditure made on health reached close to 10% of the GDP of the world and crossed a value of USD 7 trillion.

U.S. Market recovers fast; In a release on May 4th 2021, the U.S. Bureau and Economic Analsysis and U.S. Census Bureau mentions the recovery in the U.S. International trade in March 2021. Exports in the country reached $200 billion, up by $12.4 billion in Feb 2021. Following the continuous incremental trend, imports tallied at $274.5 billion, picked up by $16.4 billion in Feb 2021. However, as COVID19 still haunts the economies across the globe, year-over-year (y-o-y) avergae exports in the U.S. declined by $7.0 billion from March 2020 till March 2021 whilest imports increased by $20.7 billion during the same time. This definitely shows how the market is trying to recover back and this will have a direct impact on the Healthcare/ICT/Chemical industries, creating a huge demand for Regenerative Medicine Market products.

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The Regenerative Medicine Market report provides an in-depth analysis of the Healthcare & Pharmaceuticals during the forecast period 2017-2026 which consists of the industry overview including the market size, volume, growth rate and recent trends and developments in the market based on historical and current data. The report covers detailed information about the key players, market segments, growth drivers and restraints in the industry. The report delivers an insight into the Regenerative Medicine Market which allows our clients to make informed decisions regarding the growth of their businesses.

The Regenerative Medicine Market is anticipated to reach over USD 79.23 billion by 2026 according to a new research published by Polaris Market Research. In 2017, the cell therapy dominated the global Regenerative Medicine market, in terms of revenue. North America is expected to be the leading contributor to the global market revenue in 2017.Regenerative medicine is a branch of medicine that regrows, and repairs the damaged cells in the human body. These medicines include the use of stem cells, tissue engineering, that further helps in developing new organ that function smoothly. These medicines have the caliber of developing an entire organ as these cells are multipotent. The cells are majorly isolated from bone marrow, and umbilical cord blood.

Request Free Sample Copy :-https://www.kennethresearch.com/sample-request-10070801The regenerative medicine market is primarily driven by the increasing number of individuals suffering from cancer, rising need to monitor and treating these chronic diseases in the limited time. Furthermore, stringent government policies, proper reimbursement policies, and increasing government healthcare expenditure for developing healthcare infrastructure to also boost the market growth in coming years. Also, rising number of organ transplantation, and increasing number of products in pipeline that are waiting for approval create major opportunity for the regenerative medicines in the coming years. However, some of the ethical and religious concerns for the use of stem cells, and lack of proper regulatory for the approval of various drugs would impede the market growth during the forecast period.

North America generated the highest revenue in the Regenerative Medicine market in 2017, and is expected to be the leading region globally during the forecast period. Increasing number of patients suffering from chronic diseases, improved healthcare infrastructure and health facilities, accessibility of healthcare facilities, are the primary factors driving the market growth in this region. While, Asia Pacific to be the fastest growing region in the coming years. The growth in this region is majorly attributed to the developing healthcare infrastructure of the countries like India, & China, and rising awareness for the use of regenerative medicines as an effective treatment option for chronic diseases.

The key players operating in the Regenerative Medicine market include Organogenesis Inc., Vericel Corporation, Osiris Therapeutics, Inc., Stryker Corporation, and NuVasive, Inc., Medtronic Plc., Acelity, Cook Biotech Inc., Integra LifeSciences, and C.R. Bard. These companies launch new products and collaborate with other market leaders to innovate and launch new products to meet the increasing needs and requirements of consumers

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Table of Contents1. Overview and Scope1.1. Research goal & scope1.2. Research assumptions1.3. Research Methodology1.3.1. Primary data sources1.3.2. Secondary data sources1.4. Key take-away1.5. Stakeholders2. Executive Summary2.1. Market Definition2.2. Market Segmentation3. Regenerative Medicine Market Insights3.1. Regenerative Medicine Industry snapshot3.2. Regenerative Medicine Ecosystem analysis3.3. Regenerative Medicine Market Dynamics3.3.1. Regenerative Medicine Market Forces3.3.1.1. Regenerative Medicine Market Driver Analysis3.3.1.2. Regenerative Medicine Market Restraint/Challenges analysis3.3.1.3. Regenerative Medicine Market Opportunity Analysis3.4. Industry analysis Porters five force3.4.1. Bargaining power of supplier3.4.2. Bargaining power of buyer3.4.3. Threat of substitute3.4.4. Threat of new entrant3.4.5. Degree of competition3.5. Regenerative Medicine Market PEST Analysis3.6. Regenerative Medicine Market Value Chain Analysis3.7. Regenerative Medicine Industry Trends3.8. Competitive Ranking Analysis

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Kenneth Research provides scheduled syndicated reports that help industry professionals and organizations decipher market trends to take significant decisions and plan strategies. We cater to a wide range of industries including healthcare & pharmaceuticals, ICT & telecom, automotive & transportation, energy & power, chemicals, FMCG & food, aerospace & defense, among others. Our research team ensures to track and analyze the industry on a regular basis to offer strategic business consultancy services on a global level. We, at Kenneth Research are adept at capturing descriptive insights on crucial topics to help our clients make their informed decisions.Contact Us

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Regenerative Medicine Market Size 2022 Share, Growth By Top Company, Business Opportunity, Regional Analysis, Application, Driver, Trends &...

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Space research now in Mayo’s orbit – Med City Beat

Posted: April 6, 2022 at 1:53 am

When Axiom Space launches its historic mission to the International Space Station, count on Mayo Clinic researchers to be paying close attention.

The flight, scheduled to take off Friday, will be the first all-civilian mission to the ISS. It will also represent a rare opportunity for Mayo researchers and scientists to study the crew on board as they travel through space.

Mayo is working with the crew to study signs of senescence in the crew, a process (and this is Mayos language) where a cell ages and stops dividing, but doesn't die, so it builds up in tissues throughout the body.

Looking for signs of senescence, according to Mayo, could help inform longer-haul trips such as a potential mission to Mars.

"The Mars mission may be very difficult to accomplish, unless we can find ways to monitor for senescent cell burden," saidDr. James Kirkland, director ofMayos Robert and Arlene Kogod Center on Aging.

Additionally, research will be conducted byDr. Andre Terzic, director of Mayos Center for Regenerative Medicine. Terzic, according to a Mayo, will be studying how to better safeguard the heart for space travel.

The Axiom Mission 1 is scheduled to launch from a SpaceX Falcon 9 rocket at NASAs Kennedy Space Center in Florida on Friday at 10:17 a.m. CT.

During their 10-day mission, the crew will spend time conducting outreach and commercial activities, in addition to their research, according to Axiom. The mission is the first of several proposed flights into space as part of the companys goal of building the first private space station.

The four civilian astronauts on the flight will be Michael Lpez-Alegra as commander; real-estate magnate and acrobatic pilot Larry Connor as pilot; and music and sustainability entrepreneur Mark Pathy, and investor and former Israel Air Force pilot Eytan Stibbe as mission specialists.

"The net result is this will benefit, if done correctly, all mankind," said Connor, a Mayo benefactor, according to the news release.

Axiom Space plans to stream the launch live online.

Cover photo courtesy Axiom Space

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Exosome Research Market worth $661 million by 2026 – Exclusive Report by MarketsandMarkets – PR Newswire

Posted: April 6, 2022 at 1:53 am

CHICAGO, April 5, 2022 /PRNewswire/ -- According to the new market research report "Exosome Research Market by Product and services (Kits, Reagents, Instrument), Indication (Cancer, Infectious Diseases), Application (Biomarkers, Vaccines), Manufacturing Services (Stem cell, Dendritic cell-derived), End User - Global Forecast to 2026", published by MarketsandMarkets, the global market is projected to reach USD 661 million by 2026 from USD 144 million in 2021, at a CAGR of 35.6% during the forecast period.

Browse in-depth TOC on"Exosome Research Market"

229 Tables 32 Figures191 Pages

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The growth of this market is driven by factors such as the rising funding for life sciences research, the high global prevalence of cancer, and the increasing interest in exosome-based procedures. However, the dearth of skilled professionals is a major factor that is expected to restrain the growth of this market to a certain extent in the coming years.

Kits & Reagents segment accounted for the largest share of exosome research market

Based on product and service, the exosome research product market is segmented into kits & reagents, instruments, and services. The kits & reagents segment is further divided into antibodies, isolation, purification, quantitation kits & reagents, and other kits & reagents. Most exosome antibodies presently commercialized in the market cannot recognize exosome-associated antigens with the required specificity and sensitivity. This has propelled several companies to develop an array of polyclonal and monoclonal antibodies against common, disease-specific exosome-based markers. This is expected to make significant contributions to the kits & reagents market in the next few years.

Cancer segment accounted for the largest share of the exosome research market

Based on indication, the exosomes market is categorized into cancer, neurodegenerative diseases, cardiovascular diseases, infectious diseases, and other indications. The exosome research product market for cancer is segmented into lung cancer, prostate cancer, breast cancer, colorectal cancer, and other cancers. The large share is attributed to the high demand for exosome research products & services in lung cancer management. The exosomes secreted by tumor cells promote tumor progression, survival, invasion, and angiogenesis. Hence, the analysis of exosomes isolated from the blood or other body fluids of cancer patients could provide insights into cancer cell biology and serve as noninvasive predictive biomarkers for early detection, progression, and metastasis.

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Biomarkers segment accounted for the largest share of the exosome research market

Based on application, the exosome research product market is segmented into biomarkers, vaccine development, tissue regeneration, and other applications. Exosomes can be isolated from easily attainable biofluids, including blood, urine, and saliva; this has supported their use as biomarkers in disease management. Exosomes are also being used in developing vaccines against the COVID-19 virus, which accounts for the high growth rate of the vaccine development segment.

Academic & Research Institutes segment accounted for the largest share of exosome research market

Based on end user, the market is segmented into academic & research institutes, hospital & clinical testing laboratories, and pharmaceutical & biotechnology companies. There has been increasing demand for exosome research in the past few years due to their potential in disease diagnosis and their emerging role as intercellular messengers. This has piqued the interest of academic research professionals, contributing to the dominance of the academic & research institutes end-user segment in the market.

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North America accounted for the largest share of the exosome research market

Based on region, the exosome research product market is segmented into North America, Europe, the Asia Pacific, and the Rest of the World. North America accounted for the largest share of the market. The US is the key revenue contributor to the North American market. The high prevalence of cancer coupled with the increasing demand for early and effective disease diagnosis and treatment is the key factor driving market growth in the US.

The prominent players operating in the exosome research market are Thermo Fisher Scientific (US), Bio-Techne (US), Lonza (Switzerland), QIAGEN N.V. (Germany), Miltenyi Biotec (US).

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Mr. Aashish MehraMarketsandMarkets INC.630 Dundee RoadSuite 430Northbrook, IL 60062USA: +1-888-600-6441Email: [emailprotected] Research Insight: https://www.marketsandmarkets.com/ResearchInsight/exosome-research-product-market.aspVisit Our Web Site: https://www.marketsandmarkets.comContent Source: https://www.marketsandmarkets.com/PressReleases/exosome-research-product.asp

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RECELL System Data to be Presented at the American Burn Association Annual Meeting – GlobeNewswire

Posted: April 6, 2022 at 1:53 am

VALENCIA, Calif. and MELBOURNE, Australia, April 04, 2022 (GLOBE NEWSWIRE) -- AVITA Medical, Inc. (NASDAQ: RCEL, ASX: AVH), a regenerative medicine company that is developing and commercializing a technology platform that enables point-of-care autologous skin restoration for multiple unmet needs, announced today that fifteen presentations highlighting the clinical and cost-savings benefits of the RECELL Autologous Cell Harvesting Device (RECELL System) for the treatment of burn wounds will be shared at the American Burn Association (ABA) Annual Meeting. The conference will be held in Las Vegas, April 5-8, and will bring together more than 2,000 multi-disciplinary burn care professionals from across the globe to discuss burn care and the latest research related to burn injuries.

The depth and breadth of the RECELL System data being presented at the American Burn Association Annual Meeting highlights the impact this platform is having on the treatment protocol for burn injuries, said Dr. Mike Perry, Chief Executive Officer of AVITA Medical. Given the substantial and growing body of data supporting the efficacy of the RECELL System for treatment of burn wounds, coupled with the real-world treatment of more than 15,000 patients globally, we look forward to building on this strong track record to expand use of the RECELL System to encompass broader indications, including soft-tissue repair and vitiligo, following the completion of our clinical trials and approval by the FDA.

RECELL System PresentationsIn the U.S., the RECELLSystem is indicated for the treatment of acute thermal burn wounds in patients 18 years of age and older or application in combination with meshed autografting for acute full-thickness thermal burn wounds in pediatric and adult patients. Physician-initiated research beyond the FDA approved indicationis not sponsored by AVITA Medicaland contains independentdata.

The RECELL System is indicated in the U.S. for treatment of acute thermal burns. The frequency of burn-related injuries and the cost of treatment are high. The Centers for Disease Control and Prevention (CDC) reported that 486,000 patients receive emergency medical treatment for burns annually. Burn injuries result in approximately 3,400 deaths each year, the third-leading cause of accidental home injury deaths. Burns covering up to 90 percent of a persons body surface area, once considered fatal injuries, have become survivable with appropriate treatment. Although split-thickness autografts are the current standard treatment, grafting is often associated with significant donor site pain, delayed healing and scarring.

ABOUT AVITA MEDICAL, INC.AVITA Medical is a regenerative medicine company with a technology platform positioned to address unmet medical needs in burns, chronic wounds, and aesthetics indications. AVITA Medicals patented and proprietary collection and application technology provides innovative treatment solutions derived from the regenerative properties of a patients own skin. The medical devices work by preparing a RES REGENERATIVE EPIDERMAL SUSPENSION, an autologous suspension comprised of the patients skin cells necessary to regenerate natural healthy epidermis. This autologous suspension is then sprayed onto the areas of the patient requiring treatment.

AVITA Medicals first U.S. product, the RECELL System, was approved by the U.S. Food and Drug Administration (FDA) in September 2018 and a new ease-of-use design was approved in 2022. The RECELL System is indicated for use in the treatment of acute thermal burns. The RECELL System is used to prepare Spray-On Skin Cells using a small amount of a patients own skin, providing a new way to treat severe burns, while significantly reducing the amount of donor skin required. The RECELL System is designed to be used at the point of care alone or in combination with autografts depending on the depth of the burn injury. Compelling data from randomized, controlled clinical trials conducted at major U.S. burn centers and real-world use in more than 10,000 patients globally reinforce that the RECELL System is a significant advancement over the current standard of care for burn patients and offers benefits in clinical outcomes and cost savings. Healthcare professionals should read the INSTRUCTIONS FOR USE - RECELL Autologous Cell Harvesting Device (https://recellsystem.com/) for a full description of indications for use and important safety information including contraindications, warnings, and precautions.

In international markets, our products are marketed under the RECELL System brand to promote skin healing in a wide range of applications including burns, chronic wounds, and aesthetics. The RECELL System is TGA-registered in Australia and received CE-mark approval in Europe. To learn more, visit http://www.avitamedical.com.

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

This press release includes forward-looking statements. These forward-looking statements generally can be identified by the use of words such as anticipate, expect, intend, could, may, will, believe, estimate, look forward, forecast, goal, target, project, continue, outlook, guidance, future, other words of similar meaning and the use of future dates. Forward-looking statements in this press release include, but are not limited to, statements concerning, among other things, our ongoing clinical trials and product development activities, regulatory approval of our products, the potential for future growth in our business, and our ability to achieve our key strategic, operational and financial goal. Forward-looking statements by their nature address matters that are, to different degrees, uncertain. Each forward-looking statement contained in this press release is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others, the timing of regulatory approvals of our products; physician acceptance, endorsement, and use of our products; failure to achieve the anticipated benefits from approval of our products; the effect of regulatory actions; product liability claims; risks associated with international operations and expansion; and other business effects, including the effects of industry, economic or political conditions outside of the companys control. Investors should not place considerable reliance on the forward-looking statements contained in this press release. Investors are encouraged to read our publicly available filings for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this release, and we undertake no obligation to update or revise any of these statements.

This press release was authorized by the review committee of AVITA Medical, Inc.

FOR FURTHER INFORMATION:

O.U.S. MediaRudi Michelson Phone +61 (0)3 9620 3333 Mobile +61 (0)411 402 737 rudim@monsoon.com.au

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DefenAge 6-Week Perfection Neck Cream Named NewBeauty Award Winner – PR Newswire

Posted: April 6, 2022 at 1:53 am

"The often-neglected area gets some serious TLCfrom DefenAge6-Week Perfection Neck Cream, an intense, treatment-like cream that has the ability to strengthen fragile skin on the neck," states Santa Monica, CA dermatologist Ava Shamban, M.D., in the NewBeauty Magazine inaugural Award article.

Each year, the NewBeauty Awards showcase the most innovative and noteworthy products with the distinct ability to solve beauty's biggest problems. NewBeauty editors and medical experts rigorously test nearly 10,000 products over six months to hand-pick the top performers in beauty.

With 19 clinical studies to support the safety and efficacy of DefenAge's formulas and Age-Repair Defensins, the 6-Week Perfection Neck Creamsignifies a breakthrough in topical skincare for tightening and moisturizing neck skin. Rich moisturization technologies, combined with the unique mechanism of action of DefenAge's exclusive Defensin-molecules, enable a multiplication effect and lead to quickly appearing results for neck skin that looks firmer, smoother, and more even-toned.

A great retinol alternative, the neck cream addresses brightness, improves the visible thickness of the skin, and reduces the appearance of the wrinkles on the neck where aging is often more noticeable.

With an extended clean beauty profile, the 6-Week Perfection Neck Cream does not contain parabens, fragrances, formaldehydes, and phthalates. A leader in clinically clean beauty, DefenAge is the only physician-dispensed brand that makes both claims 'free from animal- and human- derived ingredients.'

"We are thrilled to receive the NewBeauty honor for the third time," shares Nikolay Turovets, Ph.D., CEO of DefenAge. "The NewBeauty Awards are a leading and trusted program in the beauty space and we're privileged to be recognized as skincare technology leaders by NewBeauty editors, physicians, and readers."

Theneck tightening creamretails online on the brand's website,defenage.com, and through dermatologists and aesthetic surgeons, med spas, and other professional aesthetic service providers.

About DefenAge:DefenAge is an American company founded in 2014 by a team of regenerative medicine experts whose anti-aging discovery became the heart and soul of its formulas. DefenAge's products are widely recommended by dermatologists as a high-performing, anti-aging cosmetic skincare for visible skin rejuvenation and as a safe alternative for retinol. DefenAge complies with or exceeds the Clean Beauty standards and its products have never been tested on animals. Honesty, transparency, and excelling in every way possible are the company's standards.

http://www.defenage.com@defenageskincare

CONTACT:KELZ MEDIASheila McCrink[emailprotected] (646) 450-5359 @KELZPR

SOURCE DefenAge

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Penn Researchers Develop Injectable Microtissue to Preserve Muscle Function in Rats with Severed Sciatic Nerves – Penn Medicine

Posted: April 6, 2022 at 1:53 am

A TE-NMI in vitro and reinnervated muscle fiber after delayed nerve repair following TE-NMI excision.

PHILADELPHIA Researchers engineered the first injectable microtissue containing motor and sensory neurons encased in protective tissue, called tissue engineered neuromuscular interfaces (TE-NMIs). The TE-NMI neurons provide a source of axons to muscles in rats who suffered nerve injuries, and babysit the muscles to prevent degeneration and loss of function, while the damaged nerve regrows, according to researchers at the Perelman School of Medicine at the University of Pennsylvania. Their findings were published in Bioactive Materials.

The TE-NMIs are comprised of nerve cells encapsulated in a protective hydrogel, and the entire microenvironment is injected in close proximity to muscles. This ship in a bottle method protects the neurons and increases the likelihood that a greater quantity of axons will connect with the muscle and maintain regenerative pathways.

Researchers severed the sciatic nerve in rats, and injected them with either a TE-NMI or a microtissue without any neurons. In the group that received TE-NMIs, researchers were able to electrically stimulate the nerve stump being babysat by the TE-NMI and record a muscle response up to five months after the tissue was implanted. No muscle response was detected in the control group.

There are hundreds of thousands of patients who undergo surgery to repair nerve injuries every year, and even if a surgeon performs a perfect procedure, they cant make axons regrow faster than about one inch per month. For nerve injuries in the upper arm or upper leg, regeneration could take years; however, the pathway leading to the muscle and the muscle itself will irreparably degenerate after six to 12 months without connections from axons, resulting in permanent loss of motor and sensory function, said senior author D. Kacy Cullen, PhD, an associate professor of Neurosurgery. By increasing the time window for a patients axons to reconnect to muscle, this research has potential to improve the extent of recovery for patients without causing further damage.

For example, patients who suffer from a brachial plexus injury a nerve root avulsion where nerves are pulled away from the spinal cord may regain elbow function, but will likely never regain function of their hand. In these cases, a neurosurgeon would typically split a healthy nerve near the hand, and reroute it to stimulate the hand muscles to restore partial function while the nerve regrows. TE-NMIs would potentially do a more thorough job, without having to damage a patients healthy nerve, researchers suggest.

Working closely with clinicians at Penns Nerve Center, we identified a potential surgical paradigm that would be most helpful to them and their patients, said first author Justin Burrell, PhD, a postdoctoral research fellow in the Department of Neurosurgery and the Institute for Translational Medicine and Therapeutics. Whats more, as we continue to test and reaffirm our findings, we will continue our partnership with the Nerve Center to ensure that our research is providing them with the technology they need to provide the best possible care for patients.

This study was primarily supported by the U.S. Department of Defense (W81XWH-16-1-0796, W81XWH-19-1-0867), the National Institutes of Health (R44-NS108869, TL1-TR001880), and the Department of Veteran Affairs (I01-BX003748).

Editors Note: Dr. Cullen is a co-founder of Axonova Medical, LLC, and Innervace, Inc., which are both University of Pennsylvania (Penn) spinout companies focused on the translation of advanced regenerative therapies to treat nervous system disorders. Dr. Cullens laboratory at Penn receives sponsored research funding from Axonova Medical. Penn and Dr. Cullen each own equity interests in both companies, have received license-related financial consideration and may receive additional financial consideration in the future related to the licensing of certain Penn intellectual property to these companies.

Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $9.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $546 million awarded in the 2021 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 52,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2021, Penn Medicine provided more than $619 million to benefit our community.

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Jasper Therapeutics to Present Updated Data on JSP191 Conditioning in SCID Patients at the 2022 Clinical Immunology Society Annual Meeting – Yahoo…

Posted: April 6, 2022 at 1:51 am

Jasper Therapeutics

REDWOOD CITY, Calif., March 31, 2022 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ: JSPR), a biotechnology company focused on hematopoietic cell transplant therapies, today announced that updated data from the Companys ongoing study of JSP191 as single agent conditioning prior to allogeneic hematopoietic stem cell (HSC) re-transplant in patients with severe combined immunodeficiency (SCID) has been accepted for presentation as a late-breaking poster at the 2022 Clinical Immunology Society (CIS) Annual Meeting, to be held in Charlotte, North Carolina from March 31 to April 3, 2022.

Title: Update: Single-Agent Conditioning with Anti-CD117 Antibody JSP191 Shows Donor Engraftment, Nave Lymphocyte Production, and Clinical Benefit in Patients with Severe Combined Immunodeficiency (SCID)Date and Time: Friday, April 1, 2022, 1:00-2:00 p.m. ET

This updated data indicates that JSP191 at 0.6mg/kg can deplete blood stem cells, leading to long-term donor cell engraftment, immune reconstitution which positively affects the clinical status of SCID patients who suffer from poor T cell and negligible B cell immunity because they failed their first transplant, said Wendy Pang, MD, Ph.D., Senior Vice President of Research and Translational Medicine of Jasper Therapeutics. This population of SCID patients is largely without treatment options and rely on supportive therapies like life long IVIG to provide some level of immune protection. JSP191 based conditioning may provide these patients with the best chance of a safe and successful transplant and reconstituted immune system.

CIS attendees are the primary caregivers for the immune deficient patient population, we are pleased to be able to present this data at the 2022 CIS annual meeting, Ronald Martell, CEO of Jasper. We believe that with our successful clinical efforts, we are one step closer, and uniquely positioned to deliver a targeted non-genotoxic conditioning agent to patients with SCID.

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About JSP191

JSP191 is a humanized monoclonal antibody in clinical development as a conditioning agent that blocks stem cell factor receptor signaling leading to clearance of hematopoietic stem cells from bone marrow, creating an empty space for donor or genetically modified transplanted stem cells to engraft. To date, JSP191 has been evaluated in more than 100 healthy volunteers and patients. Three clinical trials for myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), severe combined immunodeficiency (SCID) and Fanconi anemia are currently enrolling. The Company plans a new study of JSP191 as a second-line therapeutic in lower risk MDS patients in 2022 as well as to a pivotal study in MDS/AML transplant in early 2023. Enrollment in additional studies are planned in patients with sickle cell disease, chronic granulomatous disease and GATA2 MDS who are undergoing hematopoietic cell transplantation.

About Jasper Therapeutics

Jasper Therapeutics is a biotechnology company focused on the development of novel curative therapies based on the biology of the hematopoietic stem cell. The company is advancing two potentially groundbreaking programs. JSP191, an anti-CD117 monoclonal antibody, is in clinical development as a conditioning agent that clears hematopoietic stem cells from bone marrow in patients undergoing hematopoietic cell transplantation. It is designed to enable safer and more effective curative allogeneic hematopoietic cell transplants and gene therapies. In parallel, Jasper Therapeutics is advancing its preclinical mRNA engineered hematopoietic stem cell (eHSC) platform, which is designed to overcome key limitations of allogeneic and autologous gene-edited stem cell grafts. Both innovative programs have the potential to transform the field and expand hematopoietic stem cell therapy cures to a greater number of patients with life-threatening cancers, genetic diseases and autoimmune diseases than is possible today. For more information, please visit us at jaspertherapeutics.com.

Forward-Looking Statements

Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as believe, may, will, estimate, continue, anticipate, intend, expect, should, would, plan, predict, potential, seem, seek, future, outlook and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding the potential long-term benefits of hematopoietic stem cells (HSC) engraftment following targeted single-agent JSP191 conditioning in the treatment of severe combined immunodeficiency (SCID) and Jaspers ability to potentially deliver a targeted non-genotoxic conditioning agent to patients with SCID. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; risks relating to uncertainty regarding the regulatory pathway for Jaspers product candidates; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that Jaspers product candidates may not be beneficial to patients or successfully commercialized; patients willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jaspers business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jaspers business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics, including the ongoing COVID-19 pandemic; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jaspers filings with the SEC. If any of these risks materialize or Jaspers assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jaspers assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.

Contacts:John Mullaly (investors)LifeSci Advisors617-429-3548jmullaly@lifesciadvisors.com

Jeet Mahal (investors)Jasper Therapeutics650-549-1403jmahal@jaspertherapeutics.com

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Jasper Therapeutics to Present Updated Data on JSP191 Conditioning in SCID Patients at the 2022 Clinical Immunology Society Annual Meeting - Yahoo...

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A juicy tomato this summer begins with starting sturdy transplants now. – Vermont Public Radio

Posted: April 6, 2022 at 1:50 am

The wait is over! The time to start tomatoes in our region is here.

If you garden in the Champlain Valley or lower Connecticut River Valley, begin planting tomato seeds indoors now.

If you're in the mountains, give it just one more week or so till mid-April to start them.

And as tomato varieties are nearly endless, if you're starting from seed, try some unusual types this season.

Once you've chosen a few varieties, take the seeds and sow them into two-inch diameter pots filled with potting soil. Place a couple tomato seeds in each pot.

As they germinate, thin them out to just one seedling per pot.

At this point in your seed-prep, you'll need to veer a bit from the usual practice of placing the seedlings to grow in a sunny spot indoors.

Placing your seedlings under grow lights will be a game-changer.

Grow lights placed just a couple of inches above the seedlings will be essential for the seedlings to grow strong and stay small and stocky.

Though tall, leggy seedlings grown on your sunny windowsill can certainly be transplanted into your garden, it might take them longer to catch up.

So to get a small, stocky and fast-growing seedlings, grow lights are the way to go.

Once the seeds begin germinating, keep moving the lights as they grow so they are about two inches above the seedlings.

You can also mimic the natural world by brushing your hand across the new seedlings, almost like you're petting a cat! This motion imitates the wind that would brush against the seedling outdoors.

Once they're about two and a half inches tall, start brushing them with your hand about 10 times once per day.

Doing this practice daily basis helps stimulate the cells on the sides of the stem to get bigger and doing so helps the plants stay shorter and stockier. You can actually reduce the height of your seedlings by about 20%.

Once the seedlings' height is three times the diameter of the container, repot them into a larger container and keep them growing strong, using your brushing technique!

When you're ready to transplant them into your garden or raised bed, you can harden them off by first taking them outside for an hour or so the first day. Then extend that period for about five or six days until you can leave them outside full time.

Hardening the seedling transplants will help prevent any kind of sunscald or stress due to the wind, weather or cold.

Once they are full-time outdoor residents, pop them into the garden soil and you'll be eating tomatoes in the summertime!

A: Try to pull fig tree out of the container and knock off a bunch of the soil. It might mean taking out most of the potting soil to get rid of the any colony.

Then clean the inside of the container with a 10% bleach solution. Once clean, repot the fig with fresh potting soil and hopefully that will keep the ants away.

If you can evict the queen from the colony that has formed in your fig tree container, that will prevent them from coming back and recolonizing.

Virtually any vegetable does well in a grow bag! Grow bags are made from a breathable fleece material and come in bright colors and a variety of sizes.

As the plant's roots get big, they get naturally air-pruned and won't become rootbound in a grow bag.

Another bonus to using grow bags is you can move them as needed into the sunniest spots in your yard.

Then when the season is over, dump out the compost or potting soil, wash the grow bags out if you like, then fold and stack them until next season!

All Things Gardening is powered by you, the listener! Send your gardening questions and conundrums and Charlie may answer them in upcoming episodes. You can also leave a voicemail with your gardening question by calling VPR at (802) 655-9451.

Hear All Things Gardening during Weekend Edition Sunday with VPR host Mary Engisch, Sunday mornings at 9:35.

Have questions, comments or tips?Send us a messageor get in touch by tweeting us@vprnet.

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How Can You Help Patients Use New Diabetes Technologies? | NIDDK – National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Posted: April 6, 2022 at 1:49 am

New technologies can improve diabetes outcomes. Learn how health care professionals can help patients access and use these tools.

Diabetes technologies arent reaching everyone who could potentially benefit. Dr. Tamara K. Oser, a primary care doctor and diabetes researcher, discusses how health care professionals can put diabetes technologies into practice.

Q: What technology tools are available for people with diabetes?

A: Weve seen an expansion in the world of diabetes technologies that, if used the right way, can improve diabetes care. We now have continuous glucose monitors (CGMs), insulin pumps that are increasingly automated, connected insulin pens, and apps. Health care professionals and people with diabetes can use technology in many ways to foster diabetes self-management education and support.

Q: How can new technologies benefit people who have diabetes?

A: More evidence is emerging about the benefits of diabetes technologies. For instance, continuous glucose monitoring is associated with improved clinical, psychosocial, and behavioral outcomes, especially for people who have type 1 diabetes or type 2 diabetes that requires intensive insulin therapy. Evidence is also emerging about the benefits of continuous glucose monitoring for people with type 2 diabetes on basal insulin, and even for people with type 2 diabetes who are not on insulin.

However, just having a technology tool doesnt necessarily improve outcomes. Health care professionals and patients with diabetes also need education about how to use the device, how to engage with the data, and how to communicate with each other about the data. For example, when patients start to use CGMs, health care professionals should ask them how often they want to receive CGM alarms. If you dont have this conversation, patients may get too many alarms and develop alarm fatiguemeaning they no longer respond appropriately to alarmsand stop using the device.

There are also exciting advances in insulin pump therapy, including automated insulin delivery systems and work being done to expand access to these technologies as well.

Q: Are diabetes technologies made available to everyone who could benefit from them?

A: No. One study found that continuous glucose monitoring reached about 30% of people with type 1 diabetes in the T1D Exchange Registry, who mostly received care from endocrinologists at academic medical centers. However, we can assume that continuous glucose monitoring is less common among people who receive care from community medical practices, which is where most Americans receive care. We know that about 50% of adults with type 1 diabetes and 90% of adults with type 2 diabetes receive diabetes care from primary care providers, but most of the studies on diabetes technologies are conducted through endocrinology practices at academic medical centers.

So, there may be a geographic disparity in access to diabetes technologies. Our research team is working on many projects to address that geographic disparity and help implement diabetes technologies in primary care.

Q: Are there other disparities in the use of diabetes technologies? How do social determinants of health affect how people with diabetes access and use technology tools?

A: There are also socioeconomic, racial, and ethnic disparities in the use of diabetes technologies. Compared with the white population, racial and ethnic minority groups have higher rates of diabetes and often have worse diabetes outcomes. Patients from racial and ethnic minority groups and patients of lower socioeconomic status are less likely to be offered diabetes technologies.

However, studies have shown that when these patients are given access to diabetes technologies, they have outcomes that are similar to those of white patients or patients with higher socioeconomic status. At the Federally Qualified Health Center where I care for a large immigrant and refugee population, Ive used CGMs with my patients, and theyve done brilliantly.

One reason for disparities in access to diabetes technologies may be implicit bias that affects which patients are offered diabetes technologies. As health care professionals, we need to address our unconscious biases about which patients may or may not benefit from technologies. Other reasons for disparities include physician shortages and restrictive insurance eligibility criteria.

We have a lot of work to do to address disparities. This is a topic Im very passionate aboutmaking sure certain populations arent left behind as diabetes technologies advance.

Q: What are the barriers to using diabetes technologiesboth for health care professionals and for people with diabetes?

A: Compared with endocrinology practices in academic medical centers, primary care practices and community endocrinology practices have different resources and workflows, and how we implement diabetes technology in each setting will be different.

One way that primary care practices can address limitations, in terms of time and workflow, is to engage the entire health care teamincluding diabetes care and education specialists, clinical pharmacists, health coaches, and patient navigatorsin implementing diabetes technologies. A recent Association of Diabetes Care and Education Specialists technology summit brought together a multidisciplinary group of health care professionals to discuss broadening access to diabetes technologies. I also worked with the American Academy of Family Physicians on a Transformation in Practice Series course that provides a comprehensive approach to implementing continuous glucose monitoring in primary care.

For patients with diabetes, one barrier is lack of access, either because they arent offered diabetes technologies or because they lack insurance coverage for technologies. However, even if patients have access, lack of education and support can be a barrier to using diabetes technologies effectively.

Q: What role can a diabetes care and education specialist (DCES) play in helping people with diabetes overcome barriers to using new technologies?

A: A DCES can serve as a technology champion. Any practice that has a DCES is set up for a much greater likelihood of success. The DCES can partner with the patient and the rest of the health care team to address issues related to diabetes technologies, including

However, our team, in partnership with the American Academy of Family Physicians National Research Network and other practice-based research networks, conducted a national survey of 656 primary care providers, and only 36% had a DCES in their practice, even part time. Because the majority of primary care practices dont have access to that valuable resource, we need to consider how a DCES may be able to support multiple practices through telehealth or other novel ways of providing care.

Q: How can other health care professionals integrate technology into diabetes care?

A: Practices that dont have a DCES might have a pharmacist, a health coach, or a case manager who can serve as a technology champion or work as part of a multidisciplinary team to help integrate technology into diabetes care.

Health care professionals can also tailor their approach. If your primary care practice isnt currently using diabetes technology, you might start by choosing a technology that will be most relevant to your patient population. You can then identify members of your health care team who can help implement diabetes technology with patients.

Also, patients may benefit from a diabetes technology even if they arent able or dont want to use every aspect of the technology. I have patients who don't have a smartphone or dont want to use an app, and they just use a reader for continuous glucose monitoring. The reader captures important metrics that we go over together, and Ive seen huge improvements in diabetes management.

Q: What research is being conducted on the use of diabetes technologies?

A: This is an exciting field, and lots of research is going on right now. My research group is studying ways to implement CGM and automated insulin delivery systems in primary care. Other research groups are conducting a study to compare fingerstick blood glucose monitoring to CGMs in primary care practices. Other studies are looking at insulin dosing algorithms in patients using CGMs or fingerstick blood glucose monitoring in a wide range of practice settings.

Many studies are looking at how to use diabetes technology to help patients with self-management and education. The COVID-19 pandemic has demonstrated the benefits of remote monitoring and alternative care models outside the clinic walls.

How do you help patients with diabetes learn about and use diabetes technologies? Tell us below in the comments.

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