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CARsgen 2021 Annual Results: Steady Advancement in Innovative CAR T Products and Technologies – PR Newswire

Posted: March 25, 2022 at 2:04 am

Dr. Zonghai Li, Founder, Chairman of the Board, Chief Executive Officer, and Chief Scientific Officer of CARsgen Therapeutics Holdings Limited, commented that, "This is the first Annual Results following CARsgen's listing on the Hong Kong Stock Exchange on June 18, 2021. In the past year, CARsgen has made important progress, especially in pipeline development, technology innovation, CMC capacity expansion, business development, and strengthening our leadership team. Driven by the vision of Making Cancer Curable, we will continue to advance our product pipeline, develop innovative technologies, and consolidate our global strategy. We believe that we can bring innovative and differentiated cell therapy to cancer patients around the world as soon as possible, creating value for investors and the public."

1. Rapid progress of pipeline products

CT053

CT053 is an autologous CAR T-cell product candidate against BCMA being developed for the treatment of relapsed/refractory multiple myeloma (R/R MM). It incorporates a CAR construct engineered by CARsgen that features a fully human BCMA-specific single-chain variable fragment with lower immunogenicity and increased stability, which reduces the self-activation of CAR T-cells in the absence of tumor associated targets.

CARsgen has completed subject enrollment in the pivotal Phase II trial in China (LUMMICAR STUDY 1). In addition, CARsgen has started the pivotal Phase 2 clinical trial in North America (LUMMICAR STUDY 2) and treated the first subject in the pivotal Phase 2 trial in August 2021. As communicated with the U.S. FDA, the company is adding outpatient administration of CT053 into its U.S. clinical investigations.

CARsgen plans to make regulatory submissions for marketing approval to the NMPA in the first half of 2022 and plans to submit the BLA to the U.S. FDA in 2023. The company also plans to conduct additional clinical trials to develop CT053 as an earlier line of treatment for multiple myeloma.

Additional data update from the Phase I/II study in China (LUMMICAR STUDY 1) and an integrated analysis in participants with R/R MM by high-risk factors have been available as posters at the 2021 American Society of Hematology ("ASH") Annual Meeting in December 2021.

CT041

CT041 is an autologous CAR T-cell product candidate against the protein Claudin18.2 (CLDN18.2) and has the potential to be first-in-class globally. CT041 targets the treatment of CLDN18.2 positive solid tumors with a primary focus on gastric/gastroesophageal junction cancer (GC/GEJ) and pancreatic cancer (PC). In addition to the investigator-initiated trials, CARsgen has initiated a Phase Ib clinical trial for advanced GC/GEJ and PC and a confirmatory Phase II clinical trial for advanced GC/GEJ in China, and initiated a Phase 1b clinical trial for advanced gastric or pancreatic adenocarcinoma in North America.

In North America, CARsgen has initiated the Phase 1b trial of CT041-ST-02 and has treated the first subject in July 2021.

In 2020 and 2021, CT041 received Orphan Drug designation from the U.S. FDA for the treatment of GC/GEJ and Orphan Medicinal Product designation from the EMA for the treatment of advanced gastric cancer. In November 2021, CT041 was granted PRIME eligibility by the EMA for the treatment of advanced gastric cancer. In January 2022, CT041 was granted Regenerative Medicine Advanced Therapy (RMAT) Designation for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma with CLDN18.2 positive tumors.

CARsgen plans to submit an NDA to the NMPA in China in the first half of 2024 and also plans to initiate a Phase 2 clinical trial in the second half of 2022 in North America and to submit the BLA to the U.S. FDA in 2024.

CT041 has demonstrated promising therapeutic efficacy and safety in the ongoing investigator-initiated trial. The updates on the investigator-initiated trial of CT041 have been presented at the European Society for Medical Oncology Congress 2021 ("ESMO Congress 2021").

CT011

CT011 is an autologous CAR T-cell product candidate with proof-of-concept clinical data for the treatment of hepatocellular carcinoma (HCC) and has the potential to be the first-in class globally. The company has completed enrollment of a Phase I trial in China.

CT032

CT032 is an autologous CAR T-cell product candidate against CD19 being developed for the treatment of B cell Non-Hodgkin's lymphoma (NHL). The company is conducting a Phase I/II clinical trial in China.

AB011

AB011 is a humanized monoclonal antibody product candidate against CLDN18.2 being developed for the treatment of CLDN18.2 positive solid tumors. During the second quarter 2021, CARsgen received supplemental application approval by CDE regarding the addition of a chemotherapy combination cohort with AB011 in Phase Ib, and the company has subsequently initiated the combination cohort of AB011 with chemotherapy. The company completed Phase I monotherapy cohort enrollment and initiated combination with chemotherapy.

The company plans to consult with the NMPA in the second half of 2022 and to initiate the subsequent Phase II clinical trial.

CT0180

CT0180 is an autologous T cell product engineered to express a fusion protein of GPC3-targeted antibody fused T cell receptor (aTCR). Preclinical studies have shown that CT0180 could effectively recognize and kill GPC3-positive hepatocellular carcinoma cells and significantly inhibit HCC tumor growth in mouse xenograft models with reduced cytokine release compared to GPC3-CAR T-cells in vitro and in vivo, which improve the safety and applicability of adoptive cell therapies.

CT0181

CT0181 is an autologous T cell product engineered with GPC3-targeted antibody fused T cell receptor co-expressing IL-7 cytokine. Preclinical studies have shown that CT0181 displays superior antitumor efficacy, T cell persistence, and immunological memory in solid tumors xenografts with low cytokine release compared to GPC3-CAR T-cells.

KJ-C2111 (CT0590)

CT0590 is an allogeneic CAR T-cell product candidate deploying THANK-uCAR technology that targets BCMA. CARsgen is developing CT0590 for the treatment of relapsed/refractory multiple myeloma (R/R MM). The company has initiated IIT trial to evaluate the efficacy and safety of CT0590 for the treatment of R/R MM.

In addition, there are other IND-enabling or pre-clinical stage product candidates: KJ-C1807 (CT048), KJ-C2112, KJ-C2113 and KJ-C2114.

2. Continuous Discovery and Technology Development

Despite the approved CAR T-cell products for the treatment of terminal line hematologic malignancies, there are still significant challenges. CARsgen strives to explore and develop innovative technology platforms to address these challenges to generate better cell therapy products to global cancer patients. The main focus includes:

These technologies are currently being developed in-house with global rights and can be used alone or combined to upgrade CARsgen's existing product candidates as well as to generate future innovative pipeline product candidates.

As of December 31, 2021, CARsgen had more than 300 patents of which more than 60 patents had been issued globally including China, the United States, Europe, and Japan.

3. Manufacturing Capacity Expansion

CARsgen has established in-house end-to-end clinical and commercial manufacturing capabilities for all three stages of CAR T manufacturing, including production of plasmids, lentiviral vectors, and CAR T-cells. With the clinical manufacturing facility in Xuhui, Shanghai and commercial GMP manufacturing facility in Jinshan, Shanghai, CARsgen has been manufacturing CAR T-cells in house to support clinical trials in China and manufacturing the lentiviral vectors in house to support clinical trials globally.

The company has been expanding manufacturing capacity in China and the U.S. to support both the clinical trials and the subsequent commercialization of pipeline products. The company has opened its CGMP manufacturing facility located at the Research Triangle Park (RTP) in Durham, North Carolina ("The RTP Manufacturing Facility"). The RTP Manufacturing Facility, with a total gross floor area of approximately 3,300 sq.m, will provide additional manufacturing capacity of autologous CAR T-cell products for 700 patients annually, and it will support the company's ongoing clinical studies and early commercial launch in North America and Europe.

4. External License Agreement

CAFA Therapeutics, a subsidiary of CARsgen Therapeutics, has entered into alicensing agreement with HK inno.N Corporation (KOSDAQ: 195940) to develop and commercialize CT032 and CT053, for the potential treatment of various cancers in the Republic of Korea, with an upfront and additional milestone payments totaling up to USD50 million plus up to double-digit percentage royalties on net sales. The collaboration with HK inno.N showcases CARsgen's commitment to establishing more external partnerships with leading pharmaceutical companies to maximize the application of its technology platform and the value of its product pipeline to benefit more cancer patients globally.

About CARsgen Therapeutics Holdings Limited

CARsgen is a biopharmaceutical company with operations in China and the U.S. and is focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors. The Company has built an integrated cell therapy platform with in-house capabilities that span target discovery, antibody development, clinical trials, and commercial-scale manufacturing. CARsgen has internally developed novel technologies and a product pipeline with global rights to address major challenges of CAR T-cell therapies, such as improving the safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs. The Company's vision is to become a global biopharmaceutical leader that brings innovative and differentiated cell therapies to cancer patients worldwide and makes cancer curable.

Contact Us

For more information, please visit https://www.carsgen.com/

SOURCE CARsgen Therapeutics

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Cell-based Assay Market Projected to Reach US$ 31.4 Billion by 2027 | CAGR of 8.78% – Digital Journal

Posted: March 25, 2022 at 2:03 am

The latest report by IMARC Group, titled Cell-based Assay Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2022-2027, offers a comprehensive analysis of the industry, which comprises insights on the global cell-based assay market. The report also includes competitor and regional analysis, and contemporary advancements in the global market.

The global cell-based assay market reached a value ofUS$ 18.9 Billionin 2021. Looking forward, IMARC Group expects the market to reachUS$ 31.4 Billionby 2027, exhibiting at aCAGR of 8.78%during 2022-2027. Cell-based assay refers to the study of living cells based on their shape and size for pharmaceutical, biotechnological and biochemical applications. It involves extracting living cells from tissues, stem cells and blood samples for evaluating biochemical and functional effects of drug substances, gene activation and cell signaling. It is also utilized for the measurement of cell proliferation, motility, cytotoxicity and morphology that aids in the development of medicinal drugs and diagnosis of various diseases. As a result, it finds extensive applications for producing biologics, conducting cancer research and stem cell analysis using high-throughput screening (HTS) solutions.

We are regularly tracking the direct effect ofCOVID-19on the market, along with the indirect influence of associated industries. These observations will be integrated into the report.

Request Free Sample Report:https://www.imarcgroup.com/cell-based-assays-market/requestsample

Important Attribute and highlights of the Report:

Market Trends:

The global cell-based assay market is primarily driven by significant growth in the pharmaceutical industry. Moreover, the increasing prevalence of diabetes, cancer, neurological and cardiovascular disorders among the geriatric population is enhancing the requirement for cell-based assays for the analysis of various drug compounds. In addition, the widespread utilization of cell-based assays for the detection of coronavirus (Covid-19) infection in the body is providing a thrust to the market growth. Other factors, including significant improvements in the healthcare infrastructure, along with extensive research and development (R&D) activities in the field of biotechnology, are anticipated to drive the market toward growth.

Explore Full Report with TOC & List of Figure:https://www.imarcgroup.com/cell-based-assays-market

Competitive Landscape:

By IMARC group the report has also analyzed the competitive landscape of the market with some of thetop cell-based assay companiesbeing

Some of these key players include:

Key Market Segmentation:

Breakup by Product and Services:

Breakup by Technology:

Breakup by Application:

Breakup by End-User:

Breakup by Region:

Key highlights of the Report:

TOC for the Report:

Note: If you need specific information that is not currently within the scope of the report, we can provide it to you as a part of the customization.

Other Reports by IMARC Group:

Data Center Rack Market Report: https://www.imarcgroup.com/data-center-rack-market

Smart Bathroom Market Report: https://www.imarcgroup.com/smart-bathroom-market

Cement Market Report: https://www.imarcgroup.com/cement-manufacturing-plant

Adhesive Tapes Market Report: https://www.imarcgroup.com/adhesive-tapes-market

Aerosol Cans Market Report: https://www.imarcgroup.com/aerosol-cans-market

Aerosol Propellants Market Report: https://www.imarcgroup.com/aerosol-propellants-market

Green Cement Market Report: https://www.imarcgroup.com/green-cement-market

Mobile Mapping Market Report: https://www.imarcgroup.com/mobile-mapping-market

Semiconductor Foundry Market Report: https://www.imarcgroup.com/semiconductor-foundry-market

Smart TV Market Report: https://www.imarcgroup.com/smart-tv-market

About Us

IMARC Group is a leading market research company that offers management strategy and market research worldwide. We partner with clients in all sectors and regions to identify their highest-value opportunities, address their most critical challenges, and transform their businesses.

IMARCs information products include major market, scientific, economic and technological developments for business leaders in pharmaceutical, industrial, and high technology organizations. Market forecasts and industry analysis for biotechnology, advanced materials, pharmaceuticals, food and beverage, travel and tourism, nanotechnology and novel processing methods are at the top of the companys expertise.

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Cell-based Assay Market Projected to Reach US$ 31.4 Billion by 2027 | CAGR of 8.78% - Digital Journal

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Not Smart But Clever? The Return of ‘Dumbphones’ – WhoWhatWhy

Posted: March 25, 2022 at 2:03 am

Not Smart But Clever? The Return of Dumbphones (Maria)

The author writes, Five years ago, Przemek Olejniczak, a psychologist, swapped his smartphone for a Nokia 3310, initially because of the longer-lasting battery. However, he soon realized that there were other benefits. Before, I would always be stuck to the phone, checking anything and everything, browsing Facebook or the news, or other facts I didnt need to know, he says. Now I have more time for my family and me. A huge benefit is that Im not addicted to liking, sharing, commenting, or describing my life to other people. Now I have more privacy. Tech expert Prof Sandra Wachter, a senior research fellow in artificial intelligence at Oxford University, says it is understandable that some of us are looking for simpler mobile phones. One can reasonably say that nowadays a smart phones ability to connect calls and send short messages is almost a side feature, she explains.

From Nature: Researchers are right to be concerned. The selection of embryos on the basis of these predictions is not yet supported by science. Moreover, the societal implications of using complex genetic tests to choose embryos has not yet been fully considered. Some scientists are completely opposed to the practice, whereas others recognize that, as more data accrue, there might be benefits, but realize that it must be carefully regulated. A study published in Nature Medicine1 on 21 March that explains some of the methodology behind the determination of what are called polygenic risk scores draws attention to the practice but does not allay scientists fears.

The author writes, With Idaho poised to enact one of the most restrictive abortion laws in the country, Oregon is shoring up access to abortion. Idahos measure would disallow abortion after six weeks and let family members of rapists sue abortion providers. According to the New York Times, a similar law in Texas resulted in a 60 percent drop in abortions in Texas and as much as an 800 percent increase in demand for abortions in clinics in neighboring states. Oregon is getting ready for a similar wave, and a possible end to Roe v. Wade, by passing legislation to fund support for those hardest hit by an end to reproductive health care, according to Christel Allen, executive director of Pro-Choice Oregon.

From Euronews: Rescue workers have found no survivors in the wreckage of China Eastern flight 5735, which crashed on Monday. The Boeing 737-800 aircraft went down in the remote Chinese mountainside with 123 passengers and nine crew members on board. The plane crashed outside the city of Wuzhou in the Guangxi region while flying from Kunming to Guangzhou. According to the Chinese Foreign Ministry, all the passengers are believed to be Chinese. The cause of the plane crash has not yet been revealed.

The author writes, Were 3D printing these cells into a very specific structure that mimics human anatomy, which we think is our best shot at stimulating sperm production. If successful, this could open the door to new fertility treatments for couples who currently have no other options. For the recent study, the researchers performed a biopsy to collect stem cells from the testicles of a patient living with NOA. The cells were then grown and 3D printed onto a petri dish into a hollow tubular structure that resembles the sperm-producing seminiferous tubules.

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Not Smart But Clever? The Return of 'Dumbphones' - WhoWhatWhy

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11 Stem Cell Research Pros and Cons Vittana.org

Posted: March 25, 2022 at 2:02 am

Stem cell research can be classified into two specific areas: embryonic stem cells and non-embryonic stem cells. Amniotic, induced pluripotent, and adult stem cells do not involve the creation or destruction of a human embryo to have them collected.

Even embryonic stem cells can be collected, to some extent, without the destruction of an embryo. Modern collection techniques include using stem cells that are found in the umbilical cord, in breast milk, or even in bone marrow.

The primary benefit of stem cell research is its clear potential. Since 1868, the idea of using stem cells as a medical treatment has been contemplated in one way or another, especially as we began to understand their full potential. With stem cell therapies, we have the potential to treat injuries, degenerative conditions, or even a genetic disease or disorder.

As for the primary disadvantage of stem cell research, the ethics of collecting embryonic stem cells tends to dominate the conversation. To some people, the idea of destroying an embryo to harvest cells equates to murder. For others, they see the hundreds of thousands of frozen embryos, many of which are simply thrown away after being stored for too long, as wasted potential.

Here are some additional stem cell research pros and cons to review.

1. It could treat several conditions that are virtually untreatable right now. Stem cell research opens numerous avenues for treatments or a cure to be found for several conditions that are either untreatable or without a cure today. Everything from Alzheimers disease to Parkinsons disease to ALS could be improved. People who have a spinal cord injury could receive an injection of stem cells and potentially start the recovery process. Even mental health issues, such as schizophrenia, could one day be treated with stem cell applications.

2. It provides us with greater knowledge. By researching stem cells, we understand more about the growth process of humans. We learn more about how cells form and interact with one another. We can examine pluripotent cells, both induced and embryonic, to see what information is required for them to turn into a specific tissue cell. With a greater understanding of this micro-environment, we can learn more about who we are at our very core.

3. It offers new methods of testing. When new medical treatments are proposed, they must go through multiple stages of testing. This includes animal trials and human trials, which may or may not be successful. As our knowledge of stem cells grows, we could transition testing methods so that only cell populations are examined for a response instead of an innocent animal or a paid human research contributor. That may improve safety, reduce fatalities, and even speed up the approval process.

4. It reduces the risk of rejection. Many stem cell therapies today use the cells that are collected from a patients body. Because the cells are their own, the risk of rejection is reduced or even eliminated. If stem cells could be induced to form into organ tissues, such as a kidney, then the science of organ transplantation could be forever changed. Imagine growing a kidney that is a genetic match instead of trying to find a donor organ that could be rejected, even if a direct match is found. That is the potential of this medical research.

5. It could stop birth defects and mutations before they happen. By understanding the process of stem cell development, it could be possible to change the embryonic development process. Chromosomal concerns, birth defects, and other errors in development could be corrected before birth, giving more newborns a real chance to experience the gift of life. At the same time, the risks of pregnancy loss and health risks to new mothers could be decreased.

1. We have no idea about long-term side effect issues. According to the Canadian Cancer Society, there are several common short-term side effects that are associated with stem cell therapies. They may include infection, bleeding, skin or hair problems, unexplained pain, organ problems, or even the development of a secondary cancer. Every medical treatment provides some risk of a side effect, but this medical technology is so new that we have no idea what the long-term health effects might be.

2. It provides a health risk to everyone involved. Collecting stem cells from an adult carries a medical risk with it. Something could go wrong during the collection process that may reduce the quality of life for the patient. Their life could even be placed at-risk. For embryonic collection, the destruction of the blastocytes that are formed during egg fertilization is required. Since the embryo is technically a different form of human life, there will always be the chance of rejection occurring since the cells are not ones own.

3. Adult stem cells offer limited potential. Our current stem cell research findings indicate that adult stem cells that have already transitioned into specific tissues or formats because of their body location will stay that way. That means stem cells taken from muscle tissue would only be able to create additional muscle tissues. Even if they are induced to be pluripotent, the end result tends to be duplication instead of identification because they have a determined type.

4. It is still an unproven medical technology. There is a lot of hope for stem cell treatments. Hematopoietic stem cell transplantation is performed about 50,000 times annually around the world and the success rate for the treatment is climbing above 90%. Because some forms of stem cell research are classified as illegal or immoral in the United States, however, progress to improve treatments or prove the effectiveness of this medical technology are not as advanced as their potential.

5. It isnt cheap. Stem cell therapies are far from affordable. Because most health insurers classify this type of treatment as experimental, it is rarely a covered procedure. Most treatments that are approved for use in the US cost more than $10,000 per procedure. Some treatment options are six figures. Even the cost of harvesting stem cells from an embryo is a couple thousand dollars. Access to this technology is restricted to socioeconomic means globally and to almost everyone in the United States.

6. Opportunities are limited. Although stem cell research isnt technically forbidden in the US, there are just 19 stem cell lines available for government grants and funding thanks to legislative restrictions that are enacted in 2001. Certain states have begun to draft legislation to completely ban stem cell research, or at least embryonic stem cell research, or at least place major restrictions on the process.

We should examine the ethics of embryonic stem cell research, but we should also examine the benefits it may provide. Adult stem cells, collected from consenting parties, should have no criticism whatsoever. As we move forward in this research, new pros and cons may also require additional contemplation. One thing is for certain: these stem cell research pros and cons show us that humanity is complex, beautiful, and wonderful in many ways.

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Research Associate, Cancer and Stem Cell Laboratory job with UNIVERSITY OF SYDNEY | 287031 – Times Higher Education

Posted: March 25, 2022 at 2:02 am

About the opportunity

The main focus of the Cancer and Stem Cell Laboratory is to study how normal stem cells are transformed into cancer stem cells and to develop effective new therapies that specifically target and destroy cancer stem cells. These cells, which are often resistant to chemotherapy, are now believed to be the engine driving the growth of cancer and the root cause of treatment resistance and relapse.

The Research Associate will conduct the grant-funded project. Some work may require reasonable additional hours from time to time. Depending on qualifications and expertise the applicant may be appointed at levels equivalent to Academic Level A, step 5-8. Initial appointment is for 12 months, however the position may be extended dependent on funding.

The Research Associate is required to design and develop experiments related to single cell technologies in several ongoing stem cell-associated projects. In collaboration with the bioinformatics team, the Research Associate will perform data analysis and will ensure solid interpretation of the data and potential translational applications of these technologies.

This is an exciting opportunity to be on the forefront of applying single cell technologies to crucial questions in advanced stem cell research.

Your key responsibilities will be to:

About you

Closes 11:59 pm Sunday 10 April 2022

To keep our community safe, please be aware of our COVID safety precautions which form our conditions of entry for all staff, students and visitors coming to campus.

Sponsorship / work rights for Australia

Please note: Visa sponsorship is not available for this position. For a continuing position, you must be an Australian or New Zealand citizen or an Australian Permanent Resident.

Australian Temporary Residents currently employed at the University of Sydney may be considered for a fixed term contract for the length of their visa, depending on the requirements of the hiring area and the position.

Pre-employment checks

Your employment is conditional upon the completion of all role required pre-employment or background checks in terms satisfactory to the University. Similarly, your ongoing employment is conditional upon the satisfactory maintenance of all relevant clearances and background check requirements. If you do not meet these conditions, the University may take any necessary step, including the termination of your employment.

EEO statement

At the University of Sydney, our shared values include diversity and inclusion and we strive to be a place where everyone can thrive. We are committed to creating a University community which reflects the wider community that we serve. We deliver on this commitment through our people and culture programs, as well as key strategies to increase participation and support the careers of Aboriginal and Torres Strait Islander People, women, people living with a disability, people from culturally and linguistically diverse backgrounds, and those who identify as LGBTIQ. We welcome applications from candidates from all backgrounds.

How to apply

Applications (including a cover letter, CV, and any additional supporting documentation) can be submitted via the Apply button at the top of the page.

If you are a current employee of the University or a contingent worker with access to Workday, please login into your Workday account and navigate to the Career icon on your Dashboard. Click on USYD Find Jobs and apply.

For a confidential discussion about the role, or if you require reasonable adjustment or support filling out this application, please contact Scott Walker Recruitment Operations, by email to

The University of Sydney

The University reserves the right not to proceed with any appointment.

Click to view the Position Description for this role.

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Research Associate, Cancer and Stem Cell Laboratory job with UNIVERSITY OF SYDNEY | 287031 - Times Higher Education

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Google still has a problem with stem cell and unproven therapies – STAT – STAT

Posted: March 25, 2022 at 2:02 am

Hey, Google: Remember that stem cell problem you tried to fix in 2019 by banning clinics from advertising unproven therapies on your platform?

The solution didnt last. Clinics have adapted, but you havent, leading to widespread use of your search platform by clinics to pitch risky cell injections.

In response to criticism that Google ads for unproven medical offerings were doing harm, the firm adopted a policy in 2019 banning stem cell clinic advertising on its platform. This positive step was part of a larger move against ads selling unproven therapies. Many of the culprits were clinics touting stem cells as treatments for everything from Alzheimers to stroke.

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After the ban was implemented, people searching for stem cells for COPD or stem cells for neuropathy, to cite just two examples, would no longer see a slew of ads for clinics offering risky, unproven therapies above the Google search results. That worked for a while. But stem cell clinics and others promoting unproven therapies now effectively game Googles search engine to get new customers.

For example, while stem cell clinics may no longer rely on Google ads to hoist themselves to the top of a search results page, some clinics still dominate large swaths of Google search results related to stem cells. In this way, the company is inadvertently sending many people to these clinics to get risky, unproven injections that generally lack FDA approval and, in my view, have no solid scientific or medical foundation.

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This weakness in Google search has become a public health issue.

The FDA has been largely ineffective at regulating stem cell clinics. Sure, it has issued warnings to a few. But hundreds of these clinics operate in the U.S., with many more worldwide. I hope the FDA becomes more aggressive in regulating the U.S. clinics and there are signs it might in the future but in the meantime Google has a responsibility to tackle its side of the problem.

Whats the issue more specifically?

For many of the most common stem-cell-related searches, Google often spits out top hits listing either websites for stem cell clinics or promotional sites that direct potential customers back to the clinics. That means if you want to know more about stem cells via Google, the search engine will often point you to the profiteering clinics as the supposed authorities.

Those troubling clinics often outrank the National Institutes of Health, the Food and Drug Administration, universities, and other authoritative sites like the Mayo Clinic in Google search results.

Take the two examples I mentioned earlier: stem cells for neuropathy and stem cells for COPD. As I write this, the number one result in each case is a stem cell clinic, which outranks the American Academy of Neurology, the American Lung Association, the NIH, and other truly authoritative sites. In the case of the neuropathy search, almost every result on the first page is a for-profit clinic selling unproven stem cell injections.

In this way, Google is putting vulnerable people at serious risk. At the very least, thousands of people are losing large amounts of money on generally useless treatments. But its more than that. Weve learned in recent years just how big a health gamble going to stem cell clinics can be with reports of patients being blinded, developing the life-threatening blood infection known as sepsis, or having other serious side effects. In rare cases, people have died.

The stem cell problem with Google and how it handles searches related to other unproven therapies ties back into search engine optimization (SEO). Put simply, SEO basically designs a website to perform in the way that Google thinks is best. The websites with the top SEO will almost always rank highest in Google search results, even if they are selling unproven biomedical offerings.

That has to change.

As it now stands, anyone trying to pitch an unproven therapy in theory just has to pump enough money into SEO and Google will usually rank them highly or at the very top in search results, even if the supposed treatment is bogus or dangerous. Google search has effectively become a form of advertising for sketchy health care. In the worst cases, sites ranking the highest with Google may even be selling non-FDA-approved stem cell therapies that are illegal in the U.S.

Google has known about this problem at least since the spring of 2021, but nothing obvious has changed. At that time, I was able to meet with representatives from Google about my concerns. We had an interesting talk, but I didnt get very far advocating for change.

One thing I did learn is that there are at least two sides to Google, and they dont necessarily connect well with each other. Policy people are on one side. Theyre the ones responsible for the ad ban on the stem cell clinics. The search team is on the other side, and they have a very different perspective on things.

The disconnect between the two is exemplified by the fact that many of the same stem cell clinics now barred from advertising on Google are the same ones whose websites are killing it with Google search and in that way presumably driving loads of customers to their profitable but risky clinics.

The problem related to stem cell clinics is just the tip of the iceberg. What Ive been watching with stem cells is going on much more broadly with health-care-related searches in Google. Its fairly easy to find examples of outright snake oil ranking number one in Google search. For instance, Goops page promoting jade eggs ranks best for a search for jade eggs and above the relevant information page of the Cleveland Clinic, and a search for energy healing delivers a page from a practitioner of energy healing above pages debunking the practice.

Those in charge of Google search might argue thats the way it should be. Perhaps theyd say that hopeful searchers want to be directed to purveyors of unproven health care more than to factual information, as reflected in the patterns of what searchers click on. However, the search engine has a greater responsibility to public health than to follow whatever health care hype is popular at any one particular time with the public.

The bottom line is that when it comes to health and health care, Google search is not as logical or safe as many of us might assume.

I believe that part of what is going on is that Google views its search engine as almost sacred. As a result, perhaps it doesnt want to factor in too many ethical or public safety considerations into how its search engine works.

At this point, however, Google cant afford to view its search engine in that hallowed way when it comes to health care. There are just too many websites out there purveying unproven and even risky treatments that Google nonetheless ranks highly.

Is this a solvable problem? Can Google determine what is an unproven medical offering for sale on a website? Could the company distinguish between ongoing clinical research and marketing unproven therapies? Such things could be challenging, but Im confident Google can figure it all out.

In non-health-care areas, like guides to making weapons of mass destruction or certain kinds of porn, Google already takes into consideration whether websites have questionable or illegal content or products for sale. Such websites generally dont turn up in search results. Making searches related to health care safer should be no less important.

Googles continuing stem cell problem is emblematic of a serious, broader problem with unproven biomedical offerings the company needs to address. The solution seems obvious: Selling an unproven treatment must become a consistent, major negative SEO ranking factor incorporated into the companys algorithms.

Otherwise, Google, youre continuing to enable those who sell unproven and sometimes even dangerous medical products and putting the public at risk.

Paul Knoepfler is a professor at the University of California Davis School of Medicine whose research focuses on stem cells and cancer. He writes about ethics, policy, and other matters on his blog, The Niche. Ads on The Niche are limited to reagents for stem cell researchers, not therapy for patients.

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Google still has a problem with stem cell and unproven therapies - STAT - STAT

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Medeze Named Frost & Sullivan’s 2021 Company of the Year in the Southeast Asia Stem Cell Banking Industry – PR Newswire

Posted: March 25, 2022 at 2:02 am

The company is at the forefront of innovating stem cell banking, exploring the science of longevity, and offering disruptive solutions to regenerative medicine through its pioneering healthcare technology. As a result, Medeze is reshaping the way age, illness, and incurable diseases are treated.

"Medeze is one of the most experienced mesenchymal stem cell (MSC) banks in the region. The company garnered this reputation thanks to its R&D department's commitment to high-quality research regarding advanced regenerative medicine," said Azza Fazar, Best Practices Research Analyst at Frost & Sullivan. "Medeze Group captures the surging opportunity in stem cell banking by leveraging its offerings for newborns (cord blood, placentaand cord tissue) and adults (adipose tissueand epithelial cells)."

Medeze addresses the growing needs of people who expect to have healthier and longer lives with its highly differentiated services in an industry that is rapidly evolving. The company is taking advantage of this expanding market with valuable solutions for newborns and adults, including adipose tissue, cord blood, placenta, and cord tissue banking.

In addition, its research and development (R&D) abilities position Medeze as a key player in the market and its first-class research is positively impacting patients that seek stem cell procedures. The company is increasing its services by heavily investing in leading-edge technologies and leveraging this R&D.

"Medeze dedicates its energy to R&D to create high-quality customer offerings. It takes pride in its research-backed offerings, which give physicians and patients the confidence they need when selecting the best stem cell banking solution," noted Fazar. "The company strives to expand its offerings based on the latest technologies, such as stem cell printed cornea and hair follicle banking services."

Each year, Frost & Sullivan presents a Company of the Year award to the organization that demonstrates excellence in terms of growth strategy and implementation in its field. The award recognizes a high degree of innovation with products and technologies, and the resulting leadership in terms of customer value and market penetration.

Frost & Sullivan Best Practices awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development. Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry.

About Frost & Sullivan

For six decades, Frost & Sullivan has been world-renowned for its role in helping investors, corporate leaders, and governments navigate economic changes and identify disruptive technologies, Mega Trends, new business models, and companies to action, resulting in a continuous flow of growth opportunities to drive future success. Contact us: Start the discussion. Contact us: Start the discussion.

Contact:

Kala Mani. S.Email: [emailprotected]

About Medeze

We are creating a standard of practice that is paving the way for a transformation in the way we look at age and illness. We look towards a day when saving newborn stem cells will be a routine practice and stem cell therapy will be the first line of treatment for many of today's incurable diseases. https://www.medezegroup.com/en/

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Medeze Named Frost & Sullivan's 2021 Company of the Year in the Southeast Asia Stem Cell Banking Industry - PR Newswire

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Bone Marrow-Derived Stem Cells (BMSCS) Market Report- Growth in Future with Size, Share, Growth, and Key Companies Analysis Cord Blood Registry…

Posted: March 25, 2022 at 2:02 am

The Bone Marrow-Derived Stem Cells (BMSCS) Market research report additionally researches the market regarding volume and income. The report also wraps the promoters in charge of the development of this market. It likewise includes the restrainers that can hamper the development of this market. Further, report talks about on the worthwhile opportunities that can demonstrate development in the market during the estimated time frame i.e. 2022-2029. The report gives the belief system about various components and tendencies influencing the advancement course of the overall Bone Marrow-Derived Stem Cells (BMSCS) Market. An audit of the effect of the authoritative guidelines and approaches on the Bone Marrow-Derived Stem Cells (BMSCS) Market activities is likewise incorporated into this report.

The Bone Marrow-Derived Stem Cells (BMSCS) Market research report offers a total investigation of focused elements that are changing and puts the clients in front of contenders. For simplicity of understanding and better acknowledgment of market drifts, the worldwide Bone Marrow-Derived Stem Cells (BMSCS) Market report conveys the data at local or topographical level. The report additionally edifies the conceivable effect of government laws and strategies on development are incorporated into the report. Keeping the previously mentioned factors in thought alongside the past and current circumstance of the market, the group of expert investigators has created unsurprising business sector pattern to be trailed by the market for a few up and coming years.

Global Bone Marrow-Derived Stem Cells (BMSCS) Market, By Service Type (Sample Preservation and Storage, Sample Analysis, Sample Processing, Sample Collection and Transportation), Application (Personalized Banking Applications, Research Applications, Clinical Applications) Industry Trends and Forecast to 2029.

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GlobalBone Marrow-Derived Stem Cells (BMSCS)MarketAnalysis and Size

Bone marrow biopsy is increasingly gaining attraction apart from the western economies. Rising incorporation of advanced healthcare technologies in the developing economies all around the world is carving the way for the growth of the market. Owing to the ease of harvesting and multilinear differentiation potential, bone marrow-derived stem cells (BMSCS) market has a bright future.

Data Bridge Market Research analyses that the bone marrow-derived stem cells (BMSCS) market is expected to undergo a CAGR of 10.90% during the forecast period. This indicates that the market value, which was USD 7.45 billion in 2021, would rocket up to USD 17.04 billion by 2029. Sample Preservation and Storage dominates the service type segment of the bone marrow-derived stem cells (BMSCS) market owing to the rising awareness about the practice of preserving blood cell from a new-born baby for future use.

Competitive Landscape andBone Marrow-Derived Stem Cells (BMSCS)Market Share Analysis

The bone marrow-derived stem cells (BMSCS) market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related to bone marrow-derived stem cells (BMSCS) market.

Some of the major players operating in the bone marrow-derived stem cells (BMSCS) market are:

GlobalBone Marrow-Derived Stem Cells (BMSCS)MarketDefinition

Bone marrow-derived stem cells (BMSCS) are the multipotent adult stem cells with multilineage differentiation potential. Bone marrow-derived stem cells (BMSCS) help in repairing the broken or damaged bone through secretion of factors that stimulate endogenous repair processes.

Bone Marrow-Derived Stem Cells (BMSCS)Market Dynamics

Drivers

Growing prevalence of problems accompanies with the bone marrow diseases all around the globe is one of the major factors responsible for the growth of the market. In other words, rising incidence rate of leukaemia, aplastic anaemia, myeloproliferative disorders, and others is inducing growth of the market.

Rising expenditure for research and development proficiencies especially in the developed and developing economies will further create lucrative market growth opportunities. Research and development proficiencies being conducted for sample analysis and transportation is also bolstering the market growth rate.

Surging number of public private partnerships for the development of healthcare facilities and infrastructure especially in the developing economies is fostering the growth of the market. Rising introduction of novel technologies for the preservation of stem cells and their storage as a collaborative effort of public and private players is further bolstering the growth of the market.

Opportunities

Furthermore, upsurge in the public-private funding for targetresearchactivities, rising awareness about the benefits of , growing awareness on the therapeutic potential of stem cells, rising development of novel technologies for stem cell preservation, processing and storage, rising geriatric population base and rising product innovations and development owing to technological advancements all around the world will extend profitable opportunities for the market players in the forecast period of 2022 to 2029. Additionally, rise in the birth rate, high operational costs associated with stem cell bankingand increasing per capita expenditure on health care will further expand the markets growth rate in the future.

Restraints/Challenges GlobalBone Marrow-Derived Stem Cells (BMSCS)Market

On the other hand, high cost associated with the research and development proficiencies, limited infrastructural facilities, uneven distribution of medical services and dearth of awareness in the backward economies are expected to obstruct market growth. Also, lack of favorable reimbursement scenario and technology penetration in the developing economies, high operational costs associated with stem cell banking, stringent regulatory framework, limited insurance coverage and regulatory compliance, and lack of suitable infrastructure in low- and middle-income countries are projected to challenge the market in the forecast period of 2022-2029.

This bone marrow-derived stem cells (BMSCS) market report provides details of new recent developments, trade regulations, import-export analysis, production analysis, value chain optimization, market share, impact of domestic and localized market players, analyses opportunities in terms of emerging revenue pockets, changes in market regulations, strategic market growth analysis, market size, category market growths, application niches and dominance, product approvals, product launches, geographic expansions, technological innovations in the market.

COVID-19 Impact onBone Marrow-Derived Stem Cells (BMSCS)Market

COVID-19 had a negative impact on the market. This is because of the significant disruptions experienced by their respective manufacturing companies in the pandemic era. Also, disruptions in the supply-chain operations as a result of various precautionary lockdowns further restricted the growth in this phase. Further the aim of individuals to reduce the non-essential expenses in this pandemic phase narrowed down the scope of growth. Also, restrictions imposed on the movement further created hindrances. However, the future of the market is in good shape.

Table of Contents-Snapshot

Executive Summary

Chapter 1 Industry OverviewChapter 2 Industry Competition by ManufacturersChapter 3 Industry Production Market Share by RegionsChapter 4 Industry Consumption by RegionsChapter 5 Industry Production, Revenue, Price Trend by TypeChapter 6 Industry Analysis by ApplicationsChapter 7 Company Profiles and Key Figures in Industry BusinessChapter 8 Industry Manufacturing Cost AnalysisChapter 9 Marketing Channel, Distributors and CustomersChapter 10 Market DynamicsChapter 11 Industry ForecastChapter 12 Research Findings and ConclusionChapter 13 Methodology and Data Source

For More Insights Get Detailed TOC @ https://www.databridgemarketresearch.com/toc/?dbmr=global-bone-marrow-derived-stem-cells-bmscs-market

GlobalBone Marrow-Derived Stem Cells (BMSCS)Market Scope

The bone marrow-derived stem cells (BMSCS) market is segmented on the basis of service type and application. The growth amongst these segments will help you analyze meagre growth segments in the industries and provide the users with a valuable market overview and market insights to help them make strategic decisions for identifying core market applications.

Service type

Based on service type, bone marrow-derived stem cells (BMSCS) market is segmented into sample preservation and storage, sample analysis, sample processing, sample collection and transportation.

Application

Bone marrow-derived stemcells(BMSCS) market has also been segmented based on the application into personalized banking applications, research applications and clinical applications. Research applications have been further segmented into disease treatment studies, life science research and drug discovery. Clinical applications have been further segmented into hematopoietic disorders, autoimmune disorders and other diseases.

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Data Bridge Market Researchset forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market. Data Bridge endeavors to provide appropriate solutions to the complex business challenges and initiates an effortless decision-making process.

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Autologous Stem Cell and Non-Stem Cell Based Therapies Market Future Business Opportunities 2022-2028 | Caladrius Biosciences, Vericel Corporation,…

Posted: March 25, 2022 at 2:02 am

The Autologous Stem Cell and Non-Stem Cell Based Therapies Market research provides a clear understanding of the markets major geographies, and also the key segments and sub-segments. The study focuses on the state of regional development, including sales volume, cost, and growth volume. The report also gives detailed company descriptions of leading players in the Autologous Stem Cell and Non-Stem Cell Based Therapies industry that are included in Autologous Stem Cell and Non-Stem Cell Based Therapies Market. The research investigates all of the segments based on various parameters such as market dominance, volume, and CAGR. On the fact that it is based, revenue, and sales in the Autologous Stem Cell and Non-Stem Cell Based Therapies market, the analysts have also thoroughly examined different regions such as North America, Europe, and the Asia Pacific. For this report on the Autologous Stem Cell and Non-Stem Cell Based Therapies market, the researchers employed extensive mixed research approaches and technologies.

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Brief Introduction to the research report.

Table of Contents (Scope covered as a part of the study)

Top players in the market

Research framework (structure of the report)

Research methodology adopted by Coherent Market Insights

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The analysts have segmented the global market based on raw material, type, application, sales, and region. The study also analyzes the present landscape of the ever-evolving business sector and the present and future of the market. It covers important insights pertaining to established companies operating in the global Autologous Stem Cell and Non-Stem Cell Based Therapies market. The report provides in-depth information by market segment to help you monitor performance and make important decisions for growth and profitability. The report also proposes significant data regarding marketing channel development trends and market position.

Leading players of Autologous Stem Cell and Non-Stem Cell Based Therapies Market including

Caladrius Biosciences, Vericel Corporation, Fibrocell Science, Inc., Genzyme Corporation, BrainStorm Cell Therapeutics, Regeneus Ltd., and Dendreon Corporation.

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Main Region Coverage: Production, Demand, and Forecasts by Country:

North America (USA, Canada, and Mexico)

Europe (Germany, France, UK, Russia, Italy, and other European countries)

Asia Pacific (China, Japan, Korea, India, Southeast Asia, and Australia)

South America (Brazil, Argentina, Colombia, and other South America)

The Middle East and Africa (Saudi Arabia, UAE, Egypt, South Africa, and other the Middle East and Africa)

Key Questions Answers in Autologous Stem Cell and Non-Stem Cell Based Therapies Market Report:

Which Manufacturing Morden Development Technology prefer for Autologous Stem Cell and Non-Stem Cell Based Therapies?

Who Are the current Key Players in This Autologous Stem Cell and Non-Stem Cell Based Therapies Industry with Their (Company Profile, Product Information, and Contact Information)?

What is the current as well as future market status of Autologous Stem Cell and Non-Stem Cell Based Therapies?

Who are the key stakeholders in the market?

What Are Industry Dynamics, Challenges, and Opportunities of Autologous Stem Cell and Non-Stem Cell Based Therapies Market?

What Is Economic Impact on Autologous Stem Cell and Non-Stem Cell Based Therapies Industry?

What Was the worldwide Market Status of Autologous Stem Cell and Non-Stem Cell Based Therapies Market with Capacity, Production Value, Cost, and profit?

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In the end, The Autologous Stem Cell and Non-Stem Cell Based Therapies Market Trend for Advancement is examined, along with marketing channels. Finally, the viability of new capital investments is evaluated, and research findings are presented. The Autologous Stem Cell and Non-Stem Cell Based Therapies Market Report also includes information on market share and production growth for each product in the Autologous Stem Cell and Non-Stem Cell Based Therapies market.

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This Fancy AF Face Cream Was Invented by a Stem Cell Researcher – VICE

Posted: March 25, 2022 at 2:02 am

I remember when the Augustinus Bader brand arrived on the skincare scene. It was a few years ago, and Dr. Bader himself, the accomplished biomedical scientist turned skincare brand founder, hopped on a call with me for an interview for one of New York Citys (now defunct) high fashion retail behemoths. I dont know what I was expectingsomeone pretentious? Unrelatable? Theres just so much schmoozing and so many snake-oil slingers in skincare. But I do remember feeling a massive sigh of relief once he opened up and started divulging the ethos behind his products, which have since amassed such a cult-like followingespecially thanks to one face lotion that is known simply as The Cream amongst skincare junkies.

Augustinus Bader

Bader has over 30 years of medical expertise in stem cell research. In the 1980s, he took his first steps in biomedical health at a burn center before continuing in the field of organ transplantation and then stem cell research. According to Wallpaper, his skincare brand was the by-product of its namesake's development of medical-grade cream, which could heal severe burn injuries to an extent that was previously only possible through skin graftsapplying much of the same science to other types of skin issues, from redness to wrinkles. Maybe thats why it was voted The Greatest Skincare of All Time by WWD Beauty Inc.

His line has the refreshing and rare benefit of coming not from the trend-driven beauty and wellness sector, but from the hard science of a professor who has dedicated his life to understanding the nuances of your skins health. He has a logical, down-to-earth demeanor when speaking about the decision to apply his expertise to luxury skincare, which began with one simple question: If you can heal a full wound, why not heal a wrinkle or dark spot?

The proof is in the pudding, mate; his products have become hugely popular among celebs (Kim Kardashian, Margot Robbie, Alexa Chung, Leonardo DiCaprio, and Jennifer Aniston are all known to be fans), dermatologists, and just consumers in search of skincare products that actually work, with The Cream in particular applauded for its ability to stimulate collagen production and reduce the signs of aging. Its also thanks to the inclusion of Baders TFC8 technology in the various products, or Trigger Factor Complex, which is composed of over 40 ingredients and led by Baders own decades of skincare research and clinical studies. In one four-week trial conducted with 30 participants using his products, the AB team found that after using The Rich Cream, the latest incarnation of Baders signature face lotion, 91 percent of people agreed that their skin looked five years younger and 95 percent found a dramatically improved appearance of fine lines and wrinkles. The Rich Cream is the thicker, more emollient version of the cream, specially formulated for those with dry skinand at $175 for a 30-milliliter bottle, the name is accurate in more ways than one.

Augustinus Bader

Over the years, the AB brand has expanded to include haircare products, serums, and ingestible supplements; theres a powerful, hybrid exfoliator-toner-lotion called The Essence that sounds like it belongs in The Dark Crystal, and collaborations with Spice Girls taste-making celebrities such as Victoria Beckham.

Augustinus Bader

Augustinus Bader

Look, this stuff is expensiveno denying that. But to reiterate, it was developed by a doctor in stem cell research, and the reviews are phenomenal. The real test of ABs worth came once non-celebs started giving them test runs. I am too high-maintenance for a $265 cream (alone), wrote one skeptical beauty editor about The Cream, [but] my skin tone became perceptibly more even and subtly glowy; my post-breakout dark spots faded faster [...] Augustinus Bader really is worth the hype. On Amazon, reviewers of often sold-out AB products praise the staying power of The Creams formula. It is truly amazing and LOOOONG lasting, writes one reviewer, It is not a temporary cream that washes off, and you are back to looking tired and not youthful, it is long lasting and cumulative; another reviewer said [Its] very pricey, so I was nervous. But this stuff works! You need very little, and I swear I have seen a marked improvement in my skin. Additionally, the brand allows customers to donate 5% of their order value to charity.

Perhaps youre looking to treat yourself or a family member to a treat (ATTN: Mothers Day is May 8, Fathers Day is June 19, and my birthday is July 16), or maybe youre just sick of blowing your clams on random skincare products that dont seem to work. If either of those are the case, maybe its time to stop racking up bills from the Sephora checkout line, and time to start putting in an order with the doctor.

Learn more on Augustinus Baders official website.

The Rec Room staff independently selected all of the stuff featured in this story.

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