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Guest Blog: KIP Students Suggest Ways to Stay Healthy and Safe from COVID-19 This Holiday Season – Michigan Technological University

Posted: December 24, 2021 at 2:36 am

In this guest blog, the Department of Kinesiology and Integrative Physiology shares some backstory behind the student-produced video Staying Healthy and Safe During COVID-19.

Be Smart. Do Your Part. has been the motto here at Michigan Tech since the start of the COVID-19 pandemic. A team of graduate students in the Department of Kinesiology and Integrative Physiology (KIP) did just that. The team Xinqian Chen, Isaac Lennox and Carmen Scarfone, led by doctoral student Ashley Hawke created the video Staying Healthy and Safe During COVID-19 to provide updates on latest COVID-19 trends, recommendations on how to stay safe, travel tips and strategies to maintain physical and mental health.

The two-minute video stresses the importance of relying on information from credible sources, such as the Centers for Disease Control and Prevention, state and local health departments, educational institutions and non-biased news sources. It offers a COVID-19 snapshot and has been circulated on campus. Off campus, the video has been featured in the Daily Mining Gazette and on ABC 10 TV. It has also been shared through the Western Upper Peninsula Health Department, the Copper Country Strong website, the U.P. COVID-19 Town Hall series, and the Frontline UPdates Joint Information Center social media pages.

With Michigan COVID-19 cases and hospitalizations recently reaching an all-time high and increased concerns surrounding the new omicron variant, communication of health information to help keep our campus and community safe and healthy is critical. Rural communities continue to face challenges, as they typically have a limited number of medical providers, hospital services and public health resources compared to urban communities. These students leveraged their broad-based training in health science to contribute to the COVID-19 response in their community, explained Steven Elmer, KIP associate professor and graduate program director.

Elmer also emphasized that the students video was part of a class project aimed at responding to the U.S. surgeon generals advisory statement to Build a Healthy Information Environment. The advisory statement tasks educators, researchers and professionals to confront misinformation and help improve the quality of health information so community members can make informed decisions about health for themselves and their family and community.

The graduate students behind the video hail from Michigan, Canada and China. Lennox, a masters student striving to become a physician specializing in family medicine and rural health, explained that the team also created a COVID-19 resource web page, along with a bimonthly COVID-19 infographic for KIP students, staff and faculty. With the rapidly evolving nature of the pandemic and amount of misinformation circulating, it can be difficult to keep up and stay informed. The student team collaborated with Kelly Kamm, an expert in infectious disease and epidemiology and KIP associate professor, to ensure the accuracy of all materials created.

To stay safe during this pandemic, especially with the upcoming holiday season, the students encourage everyone to get vaccinated and get a booster shot if you are already vaccinated. They also recommend following the four Ws whenever possible wear a mask, wash your hands, watch your distance and walk to stay physically active.

Looking ahead, the team will continue to do their part and use their expertise to help both the campus and community. As future health professionals, they want to learn as much as they can from the current pandemic so they are better prepared to lead during the next one.

Michigan Technological University is a public research university founded in 1885 in Houghton, Michigan, and is home to more than 7,000 students from 55 countries around the world. Consistently ranked among the best universities in the country for return on investment, the University offers more than 125 undergraduate and graduate degree programs in science and technology, engineering, computing, forestry, business and economics, health professions, humanities, mathematics, social sciences, and the arts. The rural campus is situated just miles from Lake Superior in Michigan's Upper Peninsula, offering year-round opportunities for outdoor adventure.

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Dating a Single mother: 9 suggestions for profits. If you’re when you look at the relationships games, unmarried mothers is going to be into the mix….

Posted: December 24, 2021 at 2:36 am

Dating a Single mother: 9 suggestions for profits. If youre when you look at the relationships games, unmarried mothers is going to be into the mix.

Jennifer Wolf are a PCI licensed moms and dad mentor and a strong advocate for single moms and dads.

Carly Snyder, MD try a reproductive and perinatal psychiatrist which integrates standard psychiatry with integrative medicine-based treatments.

In fact, based on a Pew Research Center research, the U.S. contains the worlds greatest rates of children living in single-parent families, particularly those work by single moms.

Individual parents bring special perspectives, concerns, and existence knowledge into the tableand which can cause them to fantastic associates. They may be frequently capable, wise, versatile, and know what they may be seeking in a relationship. This is what you need to know before dating just one momand how to take your link to the next level without obtaining extremely engaging too-soon.

Recognize That It Really Is Different

Various other affairs, maybe you have been able to gauge someones thoughts for you personally by the length of time and fuel they set in their union.

Whenever youre dating one parent, this can bent fundamentally the situation. They may nt have committed observe your as much whilstd both fancy. Solitary mothers opportunity is bound, and much of the electricity goes toward looking after their own youngsters. Youll want to look for some other expressions of their feelings obtainable.

Another variation is that lots of solitary moms tend to be most clear regarding what they demand in daily life. That may eliminate lots of puzzle and become a stylish high quality in a relationship.

For solitary parents, their own teens most likely come very first. It is advisable to comprehend and accept this fact. a mother or fathers devotion to their offspring is admirable, and investing in it can benefit improve the connection and steer clear of you against becoming jealous.

With respect to the young childs era, they might be tangled up in a mothers choice on if as of yet. Little ones and single mom typically see her connection together as highly extreme and special, and toddlers may experience some insecurity at the thought regarding father or mother https://datingreviewer.net/sugar-daddies-usa/mn/ relationships.

Youll want to appreciate that near connection and allow your spouse to navigate things in a way that makes them and their young children feel at ease.

Take It Reduce

do not try to be extreme too-soon to either your potential partner or kids. If youre undecided about how exactly engaging you want to end up being making use of the youngsters, be open and honest about this. Simultaneously, it is essential that you dont start to take on a task you cant keep for all the longterm. Proceed with the father or mothers lead with regards to the commitment together with the children.

Its crucial that you bring their partnership time and energy to establish. Dont run into getting a parental figure, moving in with each other, or acquiring involved. As an alternative, take it slow and focus on creating count on before you take the relationship to the next level.

Tell the truth and Direct

Would you discover yourself co-raising teens? Many solitary moms and dads need to know what sort of commitment you are considering from their website, and how much youre ready to commit in return. Whatever the case, its best to be truthful and communicative because beginning online dating.

Embracing honest communications straight away may have another advantage for the partnership: It promotes vulnerability, which could deliver the two of you nearer with each other.

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Dating a Single mother: 9 suggestions for profits. If you're when you look at the relationships games, unmarried mothers is going to be into the mix....

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Diabetes – World Health Organization

Posted: December 24, 2021 at 2:35 am

Overview

Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar. Hyperglycaemia, or raised blood sugar, is a common effect of uncontrolled diabetes and over time leads to serious damage to many of the body's systems, especially the nerves and blood vessels.

In 2014, 8.5% of adults aged 18 years and older had diabetes. In 2019, diabetes was the direct cause of 1.5 million deaths and 48% of all deaths due to diabetes occurred before the age of 70 years.

Between 2000 and 2016, there was a 5% increase in premature mortality rates (i.e. before the age of 70) from diabetes. In high-income countries the premature mortality rate due to diabetes decreased from 2000 to 2010 but then increased in 2010-2016. In lower-middle-income countries, the premature mortality rate due to diabetes increased across both periods.

By contrast, the probability of dying from any one of the four main noncommunicable diseases (cardiovascular diseases, cancer, chronic respiratory diseases or diabetes) between the ages of 30 and 70 decreased by 18% globally between 2000 and 2016.

Type 2 diabetes (formerly called non-insulin-dependent, or adult-onset) results from the bodys ineffective use of insulin. More than 95% of people with diabetes have type 2 diabetes. This type of diabetes is largely the result of excess body weight and physical inactivity.

Symptoms may be similar to those of type 1 diabetes but are often less marked. As a result, the disease may be diagnosed several years after onset, after complications have already arisen.

Until recently, this type of diabetes was seen only in adults but it is now also occurring increasingly frequently in children.

Type 1 diabetes (previously known as insulin-dependent, juvenile or childhood-onset) is characterized by deficient insulin production and requires daily administration of insulin. In 2017 there were 9 million people with type 1 diabetes; the majority of them live in high-income countries.Neither its cause nor the means to prevent it are known.

Symptoms include excessive excretion of urine (polyuria), thirst (polydipsia), constant hunger, weight loss, vision changes, and fatigue. These symptoms may occur suddenly.

Gestational diabetes is hyperglycaemia with blood glucose values above normal but below those diagnostic of diabetes. Gestational diabetes occurs during pregnancy

Women with gestational diabetes are at an increased risk of complications during pregnancy and at delivery. These women and possibly their children are also at increased risk of type 2 diabetes in the future.

Gestational diabetes is diagnosed through prenatal screening, rather than through reported symptoms.

Impaired glucose tolerance (IGT) and impaired fasting glycaemia (IFG) are intermediate conditions in the transition between normality and diabetes. People with IGT or IFG are at high risk of progressing to type 2 diabetes, although this is not inevitable.

Over time, diabetes can damage the heart, blood vessels, eyes, kidneys, and nerves.

Simple lifestyle measures have been shown to be effective in preventing or delaying the onset of type 2 diabetes. To help prevent type 2 diabetes and its complications, people should:

Early diagnosis can be accomplished through relatively inexpensive testing of blood sugar.

Treatment of diabetes involves diet and physical activity along with lowering of blood glucose and the levels of other known risk factors that damage blood vessels. Tobacco use cessation is also important to avoid complications.

Interventions that are both cost-saving and feasible in low- and middle-income countries include:

Other cost saving interventions include:

WHO aims to stimulate and support the adoption of effective measures for the surveillance, prevention and control of diabetes and its complications, particularly in low- and middle-income countries. To this end, WHO:

The WHO Global report on diabetesprovides an overview of the diabetes burden, interventions available to prevent and manage diabetes, and recommendations for governments, individuals, the civil society and the private sector.

The WHO module on diagnosis and management of type 2 diabetes brings together guidance on diagnosis, classification and management of type 2 diabetes in one document. The module is for policy-makers who plan service delivery of diabetes care, national programme managers responsible for training, planning and monitoring service delivery, and facility managers and primary care staff involved in clinical care and monitoring processes and outcomes of diabetes care.

In April 2021 WHO launched the Global Diabetes Compact, a global initiative aiming for sustained improvements in diabetes prevention and care, with a particular focus on supporting low- and middle-income countries. The Compact is bringing together national governments, UN organizations, nongovernmental organizations, private sector entities, academic institutions, and philanthropic foundations, people living with diabetes, and international donors to work on a shared vision of reducing the risk of diabetes and ensuring that all people who are diagnosed with diabetes have access to equitable, comprehensive, affordable and quality treatment and care.

In May 2021, the World Health Assembly agreed a Resolution on strengthening prevention and control of diabetes. It recommends action in areas including increasing access to insulin; promoting convergence and harmonization of regulatory requirements for insulin and other medicines and health products for the treatment of diabetes; and assessing the feasibility and potential value of establishing a web-based tool to share information relevant to the transparency of markets for diabetes medicines and health products.

(1) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration.

Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio et al. Lancet. 2010; 26;375:2215-2222.

(2)Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study GBD 2019 Blindness and Vision Impairment Collaborators* on behalf of the Vision Loss Expert Group of the Global Burden of Disease Study Lancet Global Health 2021;9:e141-e160.

(3) 2014 USRDS annual data report: Epidemiology of kidney disease in the United States.United States Renal Data System. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2014:188210.

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MODY: A Rare but Increasingly Common Form of Diabetes – Healthline

Posted: December 24, 2021 at 2:34 am

It wasnt until a quarter century after being diagnosed with type 1 diabetes (T1D) that Lori Salsbury in Arkansas realized the condition shed been living with since she was 15 years old might not be what she thought it was.

Though her mom and sister were both initially misdiagnosed with type 2 diabetes (T2D) and later correctly dubbed T1Ds, Lori didnt have a reason at first to be suspicious of her own T1D diagnosis. Not until 2015, when she began seeing more people with diabetes sharing their stories online and realized something was off for her.

Sure, there is a mantra in our community that Your Diabetes May Vary. But for Salsbury, the particulars of her T1D just didnt match what she saw others in the D-Community sharing or what doctors and nurses described as the symptoms most newly diagnosed T1D experience.

At the time of her diagnosis, Salsbury was in her mid-20s and seemed quite healthy. She didnt get nauseous or sick, even a full day after missing an insulin dose. Her insulin dosing needs would change frequently, often sending her into super high glucose levels for weeks until adjusting her insulin or carb ratios; the same would happen on the low end of the scale.

One day, Salsbury heard about a rare, inherited form of diabetes called MODY (maturity onset diabetes of the young), that doesnt require as much insulin, at least initially. That piqued her interest.

She did some online research, and then consulted her endocrinologist and received antibody tests that came back negative. He also ran a C-peptide test that came back at T1D levels, but that was most likely due to her 20+ years of using insulin. A referral to a geneticist led to more bloodwork, and in January 2020 the findings came back showing a genetic mutation, which causes one of the several different known types of MODY.

MODY has the potential of changing how you manage your diabetes, depending on the particular form youre diagnosed with. Some changes could include stopping medications completely or changing from insulin to a different injectable or oral medication, while some MODY forms mandate changes in your diet.

In Salsburys case, the MODY diagnosis brought her some clarity, and finally an explanation of why her diabetes experience seemed so different than others in the T1D community. But she continues insulin therapy.

Since I was originally diagnosed T1D, I am still (labeled that) in my charts so that I wont lose coverage for my insulin pump and CGM that I require to live by, Salsbury said. Most often, if asked I just tell people that I was diagnosed with type 1. Its easier than going through the whole What is MODY? spiel.

The easiest way to think about MODY is that its a subset of diabetes caused by a mutation in one of at least 14 genes in a persons DNA. That mutation impacts the insulin-producing beta cells, which in turn impacts insulin production and glucose regulation.

Since just an estimated 1 to 2 percent of those with diabetes have a genetic mutation leading to MODY, there isnt much discussion about it within the patient community, and most medical professionals dont bring it up unless they are questioned. Yet some advocates and researchers believe the various types of MODY are more common than many think, and that view is becoming more accepted as genetic testing becomes more widely available.

The term MODY was first coined in the 1970s by pioneering researchers who identified what appeared to be a mild form of diabetes in children that didnt necessarily require insulin as was needed for those with the more common juvenile diabetes (before it was later renamed type 1). At that time, MODY was defined as fasting hyperglycemia diagnosed under age 25 which could be treated without insulin for more than two years, and it is inherited, as they found.

While most research existing shows its as rare as 1 to 2 percent of all diabetes cases, more current research now indicates that as many as 6.5 percent of children with antibody-negative diabetes may have a form of MODY.

MODY is passed down genetically from parent to child, making that the common thread for this form of diabetes compared to the other types that are autoimmune, partially genetic, or more lifestyle-based. The typical diagnosis comes before age 25, and its rarely diagnosed in those older than 35 or 40. While children have roughly a 50 percent chance of developing MODY if one of their parents has it, that does not mean mutations cant occur at random and appear in those without a family history of gene mutation.

The gene mutations arent the same for everyone, and they affect different organs in the body, meaning its difficult to diagnose without genetic testing, and it can be more challenging to recognize glucose fluctuations commonly found in those who are newly diagnosed.

Significantly, 80 percent of MODY cases are misdiagnosed as T1D or T2D as the signs are pretty much the same extreme thirst, increased urination, and weight loss. But some forms of MODY do not produce any symptoms. The number of misdiagnoses may be even higher at 95 percent in the United States, according to some researchers.

Dr. Miriam Udler at Massachusetts General Hospital is one of the more well-known names in MODY clinical research. She believes more cases are being diagnosed in recent years as genetic testing has become more available, particularly after COVID-19 led to a telehealth explosion and more at-home testing kits for bloodwork and diagnostic tests normally done in a lab.

Dr. Miriam Udler

It used to be rare and expensive, and that was a barrier to testing and diagnosing MODY correctly, she told DiabetesMine. But now, more providers have access to this and can order the tests to their clinics or patients at home, and insurance is increasingly covering MODY genetic testing.

While MODY is still less common and infrequently discussed in clinics, Udler says it comes down to that particular doctor or patient recognizing something might be different about their diabetes.

That matters a lot, and a correct diagnosis can change management, Udler said. In most common MODY forms, it could mean coming off medication.

For Salsbury, the particular BLK gene mutation she has causes MODY 11, an insulin secretion defect that makes her beta cells less responsive to glucose and leads to less insulin being sent out by the body when its needed. Being overweight is one common feature of this particular gene mutation, according to research.

Once MODY is recognized and diagnosed, it can also be difficult to regulate glucose levels in the same ways that T1D and T2Ds often do, because the symptoms and glucose levels can vary significantly.

As MODY 11 usually presents like T1D and is treated in much the same way, Salsbury has been using insulin since she was diagnosed at age 15 in 1991 and wears an Omnipod tubeless insulin pump and Dexcom CGM, combined into a homemade do-it-yourself (DIY) closed loop system. For her, life with MODY isnt much different from being T1D.

But she knows everyone is not as fortunate on that front and can have many challenges in getting a correct diagnosis and finding a management routine that works for their particular form of MODY.

In New York, Laurie Jones shares her story of being diagnosed at 30 with gestational diabetes late in her first pregnancy through the test often given to pregnant women. She changed her diet and followed it to the letter on exact carb and calorie allowances, and took varying doses of long and short-acting insulins. Though she describes it as intense, all signs of diabetes went away after her first pregnancy.

But within a few years during her second pregnancy, gestational diabetes returned. She began insulin injections right away as well as a strict diet, but Jones found it more difficult than before to regulate high and low blood sugars.

A number of years later, her A1C results were creeping higher and that led to a T2D diagnosis. She took Metformin on the advice of her doctor, but it didnt work to keep her blood sugars in check.

Most adult medicine endos do not push for MODY testing even when the medicine is not working, she explained. Being overweight is usually assumed the reason, therefore even star doctors dont push for MODY testing unless weight is lost.

Her sons diagnosis changed everything. When he was 6 years old, he was diagnosed with eosinophilic esophagitis, and that mandated a diet free of the top allergens. He was about 12 when she took him to an endocrinologist, as he was not growing and low on the weight scale and didnt show any signs of puberty. That endo noticed his blood sugars were elevated and assumed he was in the honeymoon period prior to becoming a fully diagnosed T1D.

Months progressed, and the doctor suggested it was MODY. Genetic testing led to a MODY 2 diagnosis.

We had no idea what that was, and before [the doctor] explained it to us, she noted that most endocrinologists and almost all doctors outside of major medical teaching and research hospitals have not heard of it, the D-Mom said.

After her sons diagnosis, Jones got her own genetic testing and learned she also had MODY 2.

Most controlled by diet, MODY 2 is one of the more common but less intensive forms of MODY that usually doesnt require insulin or other glucose-lowering meds.

That led her to stopping Metformin, and shes been eating healthier and managing her weight for better glucose levels.

MODY 2 is not just about how you produce or use insulin, but mainly when you produce the insulin, she said. We were both told that our pancreas is like a house cooling or heating system that is off-kilter. Basically, our sugar levels have to get much higher than what is considered normal before the pancreas produces insulin. There are also insulin efficiency issues.

Without her sons diagnosis, Jones doesnt think she wouldve ever had the needed genetic testing and would have remained with a T2D diagnosis taking the wrong medications.

Thats likely the story for so many people in our D-Community, she believes.

With a 50 percent chance of being passed on, chances are MODY is not as rare as it is now believed, Salsbury said. If more people knew of it and were tested, we may come to find out that it is the most common or second only to T2D in commonality.

Importantly, a correct MODY diagnosis can highlight other health issues that might potentially arise. For example, a MODY 11 mutation to the BLK gene can increase the chances of developing systemic lupus erethematosus (SLE).

While being correctly diagnosed as MODY may not change your treatment, it can give you other information, Salsbury said. Many forms of MODY also come along with other health issues that the mutation may have caused. Knowing you have MODY can alert your doctors to watch you or check you for other related health conditions.

Researchers note the same, including Dr. Toni Pollin, a genetic researcher and counselor who in 2016 co-founded the Monogenic Diabetes Research and Advocacy Project (MDRAP) at the University of Maryland School of Medicine. The MDRAP effort promotes the correct diagnosis of MODY and also helps raise money for that effort. She co-founded MDRAP with a patient advocate whod been diagnosed with a form of MODY.

While improving MODY diagnosis will certainly improve the clinical care for patients, it will also have broader implications, researchers wrote in this 2015-published Undiagnosed MODY: Time for Action manuscript. Screening and genetic testing for MODY among patients with diabetes will provide a model for identifying and diagnosing highly penetrant forms of other otherwise common complex diseases [through] the power of genetics and genomics for improving patient care and public health.

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Check if you have undiagnosed diabetes | Waco Today | wacotrib.com – Waco Tribune-Herald

Posted: December 24, 2021 at 2:34 am

Diabetes is a chronic condition that leads to serious life-threatening complications, however many people go undiagnosed and are undertreated a situation being further exposed by the COVID-19 pandemic.

For this reason, understanding risk factors, symptoms and the importance of early diagnosis and action is essential.

More than 34 million people in the U.S. are affected by diabetes, and one-in-five of them are undiagnosed, according to estimates from Centers for Disease Control and Prevention.

Health services organization Cigna reports that between January 2020 and June of 2021, nearly 800 of its patients who were diagnosed with COVID-19 were found to have undiagnosed diabetes. Only 14% of those people had previously been diagnosed with pre-diabetes.

So why are so many people living with diabetes going undiagnosed? Cigna claims data shows that those at higher risk of having social or economic obstacles to health, also had a higher risk of undiagnosed diabetes and COVID-19.

As is the case with many medical conditions, timely diagnosis and treatment of diabetes is impacted by persisting health inequities that affect certain communities and populations, says Dr. Mandeep Brar, Cigna medical director and board-certified endocrinologist. Factors such as race, ethnicity, access to healthful food, education, health care coverage and language barriers, to name a few, all contribute to undiagnosed cases of diabetes.

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Check if you have undiagnosed diabetes | Waco Today | wacotrib.com - Waco Tribune-Herald

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What to know about claiming disability with type 2 diabetes – Medical News Today

Posted: December 24, 2021 at 2:34 am

A person who has developed a disabling condition when living with type 2 diabetes may be able to claim disability benefits. There are two types of benefits: Social Security Disability Income (SSDI), for people who have a work history, and Supplemental Security Income (SSI), which does not require a previous work history.

Type 2 diabetes results in body cells resisting the effects of insulin, which leads to impairments in a persons metabolism. Such impairments can lead to diabetes-related complications, some of which may affect a persons ability to work.

In this article, we outline some potential complications of diabetes. We also provide information on how a person with type 2 diabetes may qualify for disability benefits, the types of benefits they may be entitled to, how to apply, and how to appeal a decision. Finally, we provide tips on how to talk to an employer about a disability.

Type 2 diabetes can cause complications that may affect a persons ability to work, either in the short term or the longer term. Some examples include:

Hyperglycemia is the medical term for abnormally high blood glucose levels. This condition can result in potentially serious complications, such as diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome.

Diabetic ketoacidosis (DKA) is a serious complication of diabetes. In DKA, a lack of insulin causes the body to break down fat for energy. This process triggers the release of harmful substances called ketones, which accumulate in the blood.

The symptoms of DKA include:

A person with DKA may require hospitalization to treat or prevent complications of DKA. These complications may include:

Hyperosmolar hyperglycemic syndrome is a serious complication of diabetes, in which chronically high blood glucose levels trigger severe dehydration. This happens because excess sugar passes into the urine, causing a person to urinate more frequently.

The symptoms of HHS may include:

HHS is a potentially life threatening complication that requires urgent treatment in a hospital setting.

Chronic hyperglycemia may occur in people who have difficulty controlling their blood glucose levels. The condition may cause complications, such as:

Hypoglycemia is the medical term for abnormally low blood glucose levels. People who take insulin to control their diabetes are at increased risk of hypoglycemia.

Many people with type 2 diabetes are able to recognize the symptoms of hypoglycemia and take evasive action by consuming glucose-containing foods or beverages. Early symptoms to look out for include:

Without treatment, hypoglycemia can cause more severe symptoms, such as:

To qualify for disability benefits, a person with type 2 diabetes must provide evidence of their diagnosis and symptoms from an acceptable medical source. The evidence must be accurate and complete, and a person must submit the evidence in good time to assist claims processing.

The Social Security Administration (SSA) will consider evidence from both medical and nonmedical sources when making an assessment for disability benefits. A persons disability must have affected them for at least 12 months for them to qualify.

The medical community classifies type 2 diabetes as an unseen disability. This means that although the disability may not be visible to others, it has a significant effect on the persons day-to-day life.

The United States government takes into consideration the health problems a person with type 2 diabetes may experience that could affect their day-to-day functioning at work.

A person with this condition may need to apply for benefits if they experience one or more of the following:

The U.S. offers two different types of support for people living with conditions that result in disability: SSDI and SSI. A person will only qualify for one or both of these benefits if they are unable to work.

SSDI provides financial support for adults of any age who have worked for a qualifying period. The benefit begins after 6 full months of disability, and a person will qualify for Medicare after 24 months. This qualification will be immediate for people with amyotrophic lateral sclerosis (ALS).

SSI provides basic financial help to people of any age who have a disability and have a very limited income or resources. State programs may supplement SSI. The benefit begins 1 month after a person files the claim. In most states, a person will automatically qualify for Medicaid when they start receiving SSI.

A person may receive both benefits if they have a work history in addition to a limited income or resources.

A person may also have health insurance through their work. Some insurance policies will pay out for 12 years following disability. Longer-term health insurance policies may pay for a few years or up until the policy ends.

A person can apply for disability benefits via:

A person should have some information ready when applying for disability benefits, including:

Documents should be original or certified copies from an issuing office. A person can mail the documents or take them to a Social Security office for staff to make photocopies and return the originals.

A person will only be eligible for disability payments if they can demonstrate total or severe disability that prevents them from undertaking most work. Medical experts must expect the disability to last at least 1 year or end in death.

There is an earnings cap that changes annually. People cannot earn above this cap and continue receiving disability benefits.

A person who is turned down for disability benefits can appeal against the decision. People can appeal online or by phone within a limited period. The original response letter will provide the necessary information on how to make an appeal.

When making an appeal, a person may need to provide further information on their medical condition and any additional tests or treatments they have received since the initial decision was made.

Deciding when to disclose a disability with an employer is a personal choice. Some people may prefer to keep their disability private, particularly if it is an unseen disability. Other people may need their work to make accommodations for them, so they might wish to disclose their disability at an early stage.

People who want to talk with their employer about a disability may benefit from the following:

Type 2 diabetes can cause severe complications that may make a person eligible for disability benefits. There are two types of benefits: SSDI, which requires a qualifying length of time in work, and SSI, which can support people with disabilities at any age and time in their work career.

People can apply for disability benefits online, by phone, or by attending a prearranged appointment at their local Social Security office. People will need to provide various information, such as proof of age, their social security number, and medical records pertaining to their condition.

Some people with type 2 diabetes may feel that they would be able to continue working with appropriate adjustments within their workplace. People in this situation can talk with their employer to determine ways in which they may be able to carry out their work more effectively.

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What to know about claiming disability with type 2 diabetes - Medical News Today

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Family History of T2D May Increase MACE Risk in Those With T1D – AJMC.com Managed Markets Network

Posted: December 24, 2021 at 2:34 am

A study carried out in Taiwan found that a family history of type 2 diabetes (T2D) may increase the risks of diabetes-related complications in those with type 1 diabetes (T1D).

Patients with type 1 diabetes (T1D) and a family history of type 2 diabetes (T2D) had more diabetes complications than those without a family history of T2D, according to results of a cohort study carried out in Taiwan. Findings were published in JAMA Network Open.

T1D and T2D differ in pathophysiologic characteristics and risk factors for cardiovascular disease, authors explained. The major adverse cardiovascular events (MACEs) seen in T2D are associated with insulin resistance, whereas those in T1D are associated with the presence of renal disease, they said.

Because T1D and T2D have different mechanisms, it may be possible both diseases could develop in certain individuals, researchers hypothesized. In addition, the potential coexistence of spontaneous insulin deficiency and inherited insulin resistance could serve as a risk factor for cardiovascular disease, thus leading to an increased risk of MACEs.

To better elucidate the association between a positive family history of presumed T2D and the microvascular and macrovascular complications of T1D, authors assessed data from the Taiwan National Health Insurance Research Database (NHIRD).

The NHIRD contains demographic and clinical information of those enrolled dating back to 1995, and the NHI coverage rate was greater than 99.9% of the Taiwan population in 2005. In the present study, familial transmission was defined as the function of the difference in normal variance of the threshold from the mean liability between individuals with affected relatives and the healthy population, researchers wrote.

Of the individuals included in the analysis, 11,237 had a diagnosis of T1D and had a mean (SD) age of 22.7 (14.4) years; 54% were female. Data recorded between March 1995 and December 2017 were used to create HRs. In 2017, 1302 individuals had T1D and at least 1 first-degree relative with T2D.

Overall, the crude prevalence of T1D was 0.04%, with a female to male ratio of 1.22:1, authors explained. Furthermore, the adjusted HRs in individuals who had a first-degree relative with T2D were 2.61 (95% CI, 1.32-5.16) for MACEs at an age at diagnosis of less than 20 years.

Specifically, the incidence of hypertension and hyperlipidemia was significantly higher in this population. Adjusted HRs were 1.44 (95% CI, 1.27-1.64) for diabetic neuropathy, 1.28 (95% CI, 1.12-1.47) for retinopathy, and 1.24 (95% CI, 1.06-1.47) for neuropathy at all ages of diagnosis, they said.

Results indicate that those with T1D and a family history of T2D may have more complications and thus could require closer management. Shared environmental factors in the family could play a role in the increased risk. However, the family incidence of T2D does not account for the associations between the genetic and environmental factors of insulin resistance, and further studies are warranted to clarify the association between insulin resistance and MACEs among those with T1D.

The relatively small sample size of those with T1D in the Taiwanese population marks a limitation to the study, and researchers were unable to include information on family history of T1D, cardiovascular disease, or kidney disease.

Having T1D as well as a family history of T2D was associated with increases in individual risks of hypertension, hyperlipidemia, microvascular complications, and MACEs, they concluded. An increased focus on this patient population in the prevention of these diabetes complications is warranted in further clinical investigations.

Reference

Lin C, Lo F, Huang Y, et al. Evaluation of disease complications among adults with type 1 diabetes and a family history of type 2 diabetes in Taiwan. JAMA Netw Open. Published online December 14, 2021. doi:10.1001/jamanetworkopen.2021.38775

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Homeless dad with Type 2 diabetes says hes focused on his young daughters – PennLive

Posted: December 24, 2021 at 2:34 am

Marcos Aros was born in a coastal Chilean city whose name means Going to Heaven.

He says much of his heart remains back in Valparaiso. The rest of him resides at the Downtown Daily Bread mens shelter, off North Third Street in Harrisburg.

At least for now.

Aros, 56, says he wound up homeless despite being a 16-year U.S. Army veteran. He speaks a dozen languages. His service with the 101st Airborne Brigade, 75th Battalion, Charlie Company focused on what he called symbols in communication. Hes a master in the art of messages.

Now, hes trying to get through to his two young daughters.

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After traveling the world, Aros ended up in the Harrisburg area so he could build stronger relationships with his girls, who live with their mom in Perry County.

Aros says he sees them whenever he can. Unfortunately, that isnt very often.

I wish I could visit my daughters every other week, Aros said. I saw them the week of July 4th. Then I saw them about a month ago. I am restricted to visit my daughters because of all of this. I didnt have money to get a ride.

Another hurdle Aros faces is his health. Hes a Type 2 diabetic, and his bout of homelessness has worsened his condition. On the streets, Aros says hes forced to eat whatever I can get. Much of it isnt healthy.

Hes on insulin and several other drugs. But his bad diet landed him in the hospital several months ago. His future looked dire.

Tents, trucks & cold concrete: Inside Harrisburgs Tent City -- WATCH

Now, Aros is receiving medical care and meds through the UPMC Harrisburg Street Medicine program. The three-member team makes weekly house calls at the Downtown Daily Bread shelter. Aros granted permission for a PennLive reporter and photographer to observe and document his most recent appointment.

The recovering alcoholic tells the doctor hes down to the occasional beer. But Aros says he still smokes. His blood pressure comes in high. Dr. Michael Van Scoy writes him a new prescription for this. It will join the insulin and two diabetes drugs hes taking.

RN Laura Lacroix has Aros remove his shoes and socks so she can examine his feet. They look pretty good, she says. Then Lacroix conducts a monofilament test. She instructs Aros to close his eyes as she lightly presses the thin filament on different parts of his feet and toes.

The test reveals Aros has lost feeling on the balls of both his feet. He still has sensation in his toes and heels. But to keep it, his diabetes mustnt be allowed to get any worse.

Marcos Aros, 56, has his blood drawn by Laura Lacroix, R.N., who is with the UPMC Street Medicine Program, which holds office hours at Downtown Daily Bread in Harrisburg on Dec. 3, 2021. Aros is an Army veteran.Joe Hermitt | jhermitt@pennlive.com

Managing this chronic condition while living on the street has been a roller coaster for Aros.

I will always be sleepy and tired when my blood sugar is low, he said. When its high, I get dizzy. I know the symptoms very well. If I dont take care of that, Ill be dead. Id be in a diabetic coma. Not too good.

Aros blames the COVID-19 pandemic for knocking him into homelessness and setting him back in both his battle with diabetes and his ongoing efforts to remain in his daughters lives.

It was a quick succession of events. First went his job as a bi-lingual career adviser in Harrisburg. Then, he got evicted from his apartment, despite a federal ban on such actions during the COVID-19 crisis.

I was literally evicted illegally, he said. They took all my stuff and put it in a garage.

Afterward, Aros said he spent time in a shelter for veterans, but the housing was meant to be temporary. Before he wandered into Downtown Daily Bread last winter, Aros was sleeping among the dead at a Mount Holly Springs cemetery.

The biggest barrier to him securing a place is sky-high rents. Even with available aid through various veterans programs, Aros said the assistance lasts only so long. One must have his finances in order. Otherwise, the cycle of homelessness continues, he said.

Housing is a huge issue, he said. We are the richest country in the word, and we have veterans and civilians being homeless. There shouldnt be any homeless people in the U.S. Some people choose to be homeless. They like to be on the streets. Not me. Due to circumstance, I became homeless.

Indeed, if someone had told him hed be homeless, Aros said he would not believe that person. I wouldve thought they were totally crazy.

These days, Aros is working to reverse this situation. All of his efforts revolve around his gift for communication in multiple languages.

Aros is known as a great communicator at the Harrisburg mens shelter. While many homeless people keep to themselves, hes a social butterfly. Aros easily strikes up conversations with staff and those homeless individuals who are open to conversation.

I am a social guy, but I dont get involved with anybody, he said.

Its his girls Camila Ann, 16, and Abbey Irene, 11 whom Aros most wants to talk with. Until he can reunite in person, Aros spends time scrolling through scores of pictures of them on this smart phone. In the photos, dad and daughters are all smiles. Aros appears proud and happy. So do they.

Yet, his oldest daughter is angry, Aros says.

Shes not happy with the government that a veteran guy like me is homeless. Theyre worried about dad, he said.

Aros is doing something about this, too.

He said he has a second interview in early January for a $40,000-a-year job working with a national real estate rental company in need of his multi-lingual skills to communicate with non-English-speaking tenants.

It sounds promising, Aros said. It would be the first step toward getting a place and seeing his girls every other week.

Aros is well versed in picking up the pieces and starting over. Back in Chile, he says he was the black sheep of his family.

I was a badass teenager. I sell drugs, he said.

Then at a church camp, a Presbyterian pastor posed a provocative question. He asked the young Aros where his soul would go.

The youngster didnt hesitate. Straight to hell, Aros answered.

Thats when Aros began to change. His journey would lead him out of Chile, into the United States, the Army, two failed marriages and, finally, fatherhood.

I got saved when I was 17, he said. That did a 180 on me. I became a good man.

But hes had a bad time of it, lately.

My lifes been very complicated these last two years, Aros said.

Hopefully, not for much longer.

Im focused on my daughters, my career and my situation, Aros insisted. I am clean and sober for seven years, a recovering alcoholic. That was my drug of choice: Heineken and red wine. It went good with a steak dinner.

These days, he listens to the wise words of his mother, whos still alive and well in Chile. She never left heaven, Aros said.

Moms advice to the one she calls her tall, dark and handsome son: Pay attention to your career and give up the women!

Aros said he plans to do just that. All except for two very special females his daughters.

Marcos Aros, 56 looks at a photo of his daughters on his phone while at Downtown Daily Bread in Harrisburg on Dec. 3, 2021. Aros is an Army veteran.Joe Hermitt | jhermitt@pennlive.com

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Stem cells: Sources, types, and uses – Medical News Today

Posted: December 24, 2021 at 2:34 am

Cells in the body have specific purposes, but stem cells are cells that do not yet have a specific role and can become almost any cell that is required.

Stem cells are undifferentiated cells that can turn into specific cells, as the body needs them.

Scientists and doctors are interested in stem cells as they help to explain how some functions of the body work, and how they sometimes go wrong.

Stem cells also show promise for treating some diseases that currently have no cure.

Stem cells originate from two main sources: adult body tissues and embryos. Scientists are also working on ways to develop stem cells from other cells, using genetic reprogramming techniques.

A persons body contains stem cells throughout their life. The body can use these stem cells whenever it needs them.

Also called tissue-specific or somatic stem cells, adult stem cells exist throughout the body from the time an embryo develops.

The cells are in a non-specific state, but they are more specialized than embryonic stem cells. They remain in this state until the body needs them for a specific purpose, say, as skin or muscle cells.

Day-to-day living means the body is constantly renewing its tissues. In some parts of the body, such as the gut and bone marrow, stem cells regularly divide to produce new body tissues for maintenance and repair.

Stem cells are present inside different types of tissue. Scientists have found stem cells in tissues, including:

However, stem cells can be difficult to find. They can stay non-dividing and non-specific for years until the body summons them to repair or grow new tissue.

Adult stem cells can divide or self-renew indefinitely. This means they can generate various cell types from the originating organ or even regenerate the original organ, entirely.

This division and regeneration are how a skin wound heals, or how an organ such as the liver, for example, can repair itself after damage.

In the past, scientists believed adult stem cells could only differentiate based on their tissue of origin. However, some evidence now suggests that they can differentiate to become other cell types, as well.

From the very earliest stage of pregnancy, after the sperm fertilizes the egg, an embryo forms.

Around 35 days after a sperm fertilizes an egg, the embryo takes the form of a blastocyst or ball of cells.

The blastocyst contains stem cells and will later implant in the womb. Embryonic stem cells come from a blastocyst that is 45 days old.

When scientists take stem cells from embryos, these are usually extra embryos that result from in vitro fertilization (IVF).

In IVF clinics, the doctors fertilize several eggs in a test tube, to ensure that at least one survives. They will then implant a limited number of eggs to start a pregnancy.

When a sperm fertilizes an egg, these cells combine to form a single cell called a zygote.

This single-celled zygote then starts to divide, forming 2, 4, 8, 16 cells, and so on. Now it is an embryo.

Soon, and before the embryo implants in the uterus, this mass of around 150200 cells is the blastocyst. The blastocyst consists of two parts:

The inner cell mass is where embryonic stem cells are found. Scientists call these totipotent cells. The term totipotent refer to the fact that they have total potential to develop into any cell in the body.

With the right stimulation, the cells can become blood cells, skin cells, and all the other cell types that a body needs.

In early pregnancy, the blastocyst stage continues for about 5 days before the embryo implants in the uterus, or womb. At this stage, stem cells begin to differentiate.

Embryonic stem cells can differentiate into more cell types than adult stem cells.

MSCs come from the connective tissue or stroma that surrounds the bodys organs and other tissues.

Scientists have used MSCs to create new body tissues, such as bone, cartilage, and fat cells. They may one day play a role in solving a wide range of health problems.

Scientists create these in a lab, using skin cells and other tissue-specific cells. These cells behave in a similar way to embryonic stem cells, so they could be useful for developing a range of therapies.

However, more research and development is necessary.

To grow stem cells, scientists first extract samples from adult tissue or an embryo. They then place these cells in a controlled culture where they will divide and reproduce but not specialize further.

Stem cells that are dividing and reproducing in a controlled culture are called a stem-cell line.

Researchers manage and share stem-cell lines for different purposes. They can stimulate the stem cells to specialize in a particular way. This process is known as directed differentiation.

Until now, it has been easier to grow large numbers of embryonic stem cells than adult stem cells. However, scientists are making progress with both cell types.

Researchers categorize stem cells, according to their potential to differentiate into other types of cells.

Embryonic stem cells are the most potent, as their job is to become every type of cell in the body.

The full classification includes:

Totipotent: These stem cells can differentiate into all possible cell types. The first few cells that appear as the zygote starts to divide are totipotent.

Pluripotent: These cells can turn into almost any cell. Cells from the early embryo are pluripotent.

Multipotent: These cells can differentiate into a closely related family of cells. Adult hematopoietic stem cells, for example, can become red and white blood cells or platelets.

Oligopotent: These can differentiate into a few different cell types. Adult lymphoid or myeloid stem cells can do this.

Unipotent: These can only produce cells of one kind, which is their own type. However, they are still stem cells because they can renew themselves. Examples include adult muscle stem cells.

Embryonic stem cells are considered pluripotent instead of totipotent because they cannot become part of the extra-embryonic membranes or the placenta.

Stem cells themselves do not serve any single purpose but are important for several reasons.

First, with the right stimulation, many stem cells can take on the role of any type of cell, and they can regenerate damaged tissue, under the right conditions.

This potential could save lives or repair wounds and tissue damage in people after an illness or injury. Scientists see many possible uses for stem cells.

Tissue regeneration is probably the most important use of stem cells.

Until now, a person who needed a new kidney, for example, had to wait for a donor and then undergo a transplant.

There is a shortage of donor organs but, by instructing stem cells to differentiate in a certain way, scientists could use them to grow a specific tissue type or organ.

As an example, doctors have already used stem cells from just beneath the skins surface to make new skin tissue. They can then repair a severe burn or another injury by grafting this tissue onto the damaged skin, and new skin will grow back.

In 2013, a team of researchers from Massachusetts General Hospital reported in PNAS Early Edition that they had created blood vessels in laboratory mice, using human stem cells.

Within 2 weeks of implanting the stem cells, networks of blood-perfused vessels had formed. The quality of these new blood vessels was as good as the nearby natural ones.

The authors hoped that this type of technique could eventually help to treat people with cardiovascular and vascular diseases.

Doctors may one day be able to use replacement cells and tissues to treat brain diseases, such as Parkinsons and Alzheimers.

In Parkinsons, for example, damage to brain cells leads to uncontrolled muscle movements. Scientists could use stem cells to replenish the damaged brain tissue. This could bring back the specialized brain cells that stop the uncontrolled muscle movements.

Researchers have already tried differentiating embryonic stem cells into these types of cells, so treatments are promising.

Scientists hope one day to be able to develop healthy heart cells in a laboratory that they can transplant into people with heart disease.

These new cells could repair heart damage by repopulating the heart with healthy tissue.

Similarly, people with type I diabetes could receive pancreatic cells to replace the insulin-producing cells that their own immune systems have lost or destroyed.

The only current therapy is a pancreatic transplant, and very few pancreases are available for transplant.

Doctors now routinely use adult hematopoietic stem cells to treat diseases, such as leukemia, sickle cell anemia, and other immunodeficiency problems.

Hematopoietic stem cells occur in blood and bone marrow and can produce all blood cell types, including red blood cells that carry oxygen and white blood cells that fight disease.

People can donate stem cells to help a loved one, or possibly for their own use in the future.

Donations can come from the following sources:

Bone marrow: These cells are taken under a general anesthetic, usually from the hip or pelvic bone. Technicians then isolate the stem cells from the bone marrow for storage or donation.

Peripheral stem cells: A person receives several injections that cause their bone marrow to release stem cells into the blood. Next, blood is removed from the body, a machine separates out the stem cells, and doctors return the blood to the body.

Umbilical cord blood: Stem cells can be harvested from the umbilical cord after delivery, with no harm to the baby. Some people donate the cord blood, and others store it.

This harvesting of stem cells can be expensive, but the advantages for future needs include:

Stem cells are useful not only as potential therapies but also for research purposes.

For example, scientists have found that switching a particular gene on or off can cause it to differentiate. Knowing this is helping them to investigate which genes and mutations cause which effects.

Armed with this knowledge, they may be able to discover what causes a wide range of illnesses and conditions, some of which do not yet have a cure.

Abnormal cell division and differentiation are responsible for conditions that include cancer and congenital disabilities that stem from birth. Knowing what causes the cells to divide in the wrong way could lead to a cure.

Stem cells can also help in the development of new drugs. Instead of testing drugs on human volunteers, scientists can assess how a drug affects normal, healthy tissue by testing it on tissue grown from stem cells.

Watch the video to find out more about stem cells.

There has been some controversy about stem cell research. This mainly relates to work on embryonic stem cells.

The argument against using embryonic stem cells is that it destroys a human blastocyst, and the fertilized egg cannot develop into a person.

Nowadays, researchers are looking for ways to create or use stem cells that do not involve embryos.

Stem cell research often involves inserting human cells into animals, such as mice or rats. Some people argue that this could create an organism that is part human.

In some countries, it is illegal to produce embryonic stem cell lines. In the United States, scientists can create or work with embryonic stem cell lines, but it is illegal to use federal funds to research stem cell lines that were created after August 2001.

Some people are already offering stem-cells therapies for a range of purposes, such as anti-aging treatments.

However, most of these uses do not have approval from the U.S. Food and Drug Administration (FDA). Some of them may be illegal, and some can be dangerous.

Anyone who is considering stem-cell treatment should check with the provider or with the FDA that the product has approval, and that it was made in a way that meets with FDA standards for safety and effectiveness.

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Riverside Biologics Health Review: At Home "Stem Cells …

Posted: December 24, 2021 at 2:33 am

I get sent stuff by patients all the time. This week a patient reached out about Riverside Biologic Healths IV and injection at home umbilical cord stem cell service. Hence, lets dig in.

I received two unsolicited emails from a patient describing himself as an advocate for Regenexx:

High Tina, please pass on my request to dr. Centeno about the back ground of Riverside biologics, and also the director Dr. Neil Riodan. I attended one of their sales meetings and listened to some fantastic claims of which most were lies. One item of interest I did not understand was that the DNA becomes inactive when the cells are extracted from the fetus because of the HLA protein so there is no possibility of rejection. I tried to research this but did not get a clear understanding. All the other claims were of course the Wild West. The marketing was interesting in that in my state on rep would send post cards in each city or town inviting people to come to the meetings for healing.

Good morning doc, I remember you mentioning this outfit in one of your blogs but I would like to know more about dr. Neil Riodan and the macenna institute. I attended one of their marketing meetings in ohio and it was the wild west of stem cells. The speaker claimed that riodan had 40 patents and 70 publishings to back up all of his claims. I wont bore you with all the claims, you have heard them before, but he made one remark about no possibility of rejection using foreign live cells because of the HLA protein. I did not know what he was talking about and tried to research it and did not find anything to explain it. I will add that the procedures range from $4000 to $14000 administered in your home by a PA. At the end of the meeting I confronted the speaker about all the stuff I learned from you and he said Regenexx is a bully. Is there any truth about the HLA protein?

Thats a good question. On the website, they claim to offer both Regenerative Cell Therapy and be a Leader in Joint Pain Therapy. Their website is pretty nebulous, but lets start with this coverage map:

That word choice is interesting. Notice how instead of saying that the company has affiliates, offices, or clinics in these states, it uses the term coverage. In fact, you cant find out anything about what this coverage entails. However, a familiar name does pop up here on their website: Scott Gray, DC.

Ive blogged on Scott Gray, DC before. He is/was the CEO of Stem Cell One and Gray Marketing Enterprises. What is Stem Cell One? Another chiropractic clinic that has billed itself as Leading Umbilical Stem Cell Therapy in Marion, Ohio! Scott also owns a company called Gray Marketing Enterprises, and he used to state on his LinkedIn page, Dr Gray also published a book helping chiropractors help more patients; The Ultimate New Patient Machine. That profile, after being discussed in a prior blog has now been deleted.

Ive also blogged before on Biologics Health, a company associated with Scott Gray. When you Google Biologics Health now and Scotts name, Riverside Biologics Health comes up, so I have to assume that Scott added the word Riverside to this company.

Last year when I reviewed Scotts at-home umbilical cord stem cell service called Biologics Health, it was pretty much the same business now being described by this patient. A nurse would come to your home to give you an IV of umbilical cord stem cells. It also looks like that same nurse will perform a joint injection, but perhaps thats performed in a clinic? This was all very concerning at that time, as any such procedure should be performed in a room that looks like this:

And not like this:

Another problem was that the research back then and since, given our new paper published in the American Journal of Sports Medicine and those papers published by others, showed that commercially available umbilical cord preparations had no living stem cells (1-4). It looks like since the FDA crackdown Scott has scrubbed this new website of the phrase stem cells, but based on the patients communication above, thats still central terminology used in their seminars. Frankly, its amazing that the FDA has yet to stop this one, as IMHO I can think of few things that sound more innocuous, but in my opinion, are more dangerous than an IV umbilical cord infusion. Lets dig into that topic.

First, as discussed above, none of these umbilical cord products sold in the US have any live and functional mesenchymal stem cells. The research in this area has made that clear time and time again. However, a few of these products do have live and dying cells which are foreign tissue. When umbilical cord blood treatments are used in pediatric cancer cases, these are HLA matched to the patient (5-7). Why? The patients immune system will reject the cells, however, there will be less rejection if the cell surface markers on the umbilical cord cells are a close match to the patients own markers. However, I have yet to see a company using this stuff that matches the patient to the product.

What can happen when mismatched umbilical cord cells are injected into a body? A severe rejection reaction known as Graft vs. Host Disease (GVHD) (7). GVHD can be mild with rashes and feeling sick or it can be severe with organ failure. I know this one personally, as Im the medical expert on several legal cases where umbilical cord tissue injections were given in chiropractic and medical offices, and in my medical opinion, caused GVHD. In one case, a poor elderly man went into renal failure.

How about the salespersons statement above? This what the patient relayed was said:

One item of interest I did not understand was that the DNA becomes inactive when the cells are extracted from the fetus because of the HLA protein so there is no possibility of rejection.

Is this scientifically accurate? Nope. If you have live cells that are dying, the tissue will be read as a foreign invader by the patient and an immune response will be mounted. Now if the manufacturer made a conscious effort to kill all of the cells, that could help. However, the handout given out at the seminar by Riverside Biologics Health website says:

That certainly sounds like Riverside is claiming live cells. The rest of the brochure talks about how stem cell numbers decline with age (not actually accurate in the way portrayed, see this blog for more information).

Who gave this medical advice? Scott Boyer, a guy with a 4-year communications degree and Dale Carnegie sales training. Based on his Linkedin profile, Scott is a professional salesperson experienced in giving sales presentations and NOT a medical or scientific expert.

One of the bait and switch tactics used by these stem cell outfits is that they post research that has nothing to do with the product theyre offering to lend a veneer of credibility to their sales pitch. Riverside Biologics Health does that as well. Not a single paper listed has anything to do with the off-the-shelf umbilical cord tissue product theyre using. Even nuttier, they have listed one of my earliest research papers on using culture-expanded bone marrow stem cells in a knee, which again has nothing to do with dying umbilical cord tissue in a bottle.

Its clear from the patient that Neil Riordans product is being used in this venture. This is a product that I have blogged on called Signature Cord where the manufacture has claimed that it contains live and functional mesenchymal stem cells. Again, despite this past claim, there is no credible scientific data that this umbilical cord product contains any live and functional MSCs.

I know Neil. He has a Ph.D. and is a Physicians Assistant. He has published a slew of things about his live stem cell product being used at his clinic in Panama but has yet to publish any randomized controlled trial on those treatments. In addition, I know of no studies at all on the US product called Signature Cord, which is whats being used here. Hence, in my opinion, this is more bait and switch on the part of Riverside.

Given that Scotts Linkedin profile was deleted, I decided to see if I could find a corporate HQ for either Biologics Health or Riverside Biologics Health. That led me to a corporate registration agent in St. Pete, Florida, but no offices could be found. IMHO, thats par for the course here, as Riverside is a sales company run by a chiropractor whose career has focused on increasing the revenue of chiro practices. Meaning that Riverside is not a biotechnology venture nor is it a chain of clinics staffed by physician specialists.

The website states, the products of conception (amniotic fluid, umbilical cord, placenta, and accompanying materials) are discarded. In this case, its donated by the mother, with no harm to the baby. The materials are transferred immediately via a sterile container to a nearby FDA certified lab.Is there such a thing? Nope. The FDA doesnt certify labs that process birth tissues. You can register your lab via a free registration system (Tissue Establishment Registration), but that only tells them where to go if they want to inspect you. That doesnt mean they have certified or approved your lab.

One of the reasons that there has been a name change, adding the word Riverside to Biologics Health may be that the company received a letter from the FDA. This letter states exactly what I have reviewed, that Riverside Biologics Health is violating federal law by delivering umbilical cord IV treatments to patients. Has that stopped the company? Apparently not as they have given seminars after that date.

The upshot? At the end of the day, IMHO, sending nurses to homes to inject umbilical cord tissue is not Kosher. I hope the FDA continues to act on this one.

______________________________________

References:

(1) Berger D, Lyons N, Steinmetz, N. In Vitro Evaluation of Injectable, Placental Tissue-Derived Products for Interventional Orthopedics. Interventional Orthopedics Foundation Annual Meeting. Denver, 2015. https://interventionalorthopedics.org/wp-content/uploads/2017/08/AmnioProducts-Poster.pdf

(2) Becktell L, Matuska A, Hon S, Delco M, Cole B, Fortier L. Proteomic analysis and cell viability of nine amnion-derived biologics. Orthopedic Research Society Annual Meeting, New Orleans, 2018. https://app.box.com/s/vcx7uw17gupg9ki06i57lno1tbjmzwaf

(3) Panero, A, Hirahara, A., Andersen, W, Rothenberg J, Fierro, F. Are Amniotic Fluid Products Stem Cell Therapies? A Study of Amniotic Fluid Preparations for Mesenchymal Stem Cells With Bone Marrow Comparison. The American Journal of Sports Medicine, 2019 47(5), 12301235. https://doi.org/10.1177/0363546519829034

(4) Berger DR, Centeno CJ, Kisiday JD, McIlwraith CW, Steinmetz NJ. Colony Forming Potential and Protein Composition of Commercial Umbilical Cord Allograft Products in Comparison With Autologous Orthobiologics. Am J Sports Med. 2021 Oct;49(12):3404-3413. doi: 10.1177/03635465211031275. Epub 2021 Aug 16. PMID: 34398643.

(5) Eapen, Mary et al. Mismatched Related and Unrelated Donors for Allogeneic Hematopoietic Cell Transplantation for Adults with Hematologic Malignancies. Biology of Blood and Marrow Transplantation, Volume 20, Issue 10, 1485 1492. https://www.ncbi.nlm.nih.gov/pubmed/24862638

(6) Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104(7):19231930. https://www.ncbi.nlm.nih.gov/pubmed/15191952

(7) Holtan SG, Pasquini M, Weisdorf DJ. Acute graft-versus-host disease: a bench-to-bedside update. Blood Jul 2014, 124 (3) 363-373; DOI: 10.1182/blood-2014-01-514786

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NOTE: This blog post provides general information to help the reader better understand regenerative medicine, musculoskeletal health, and related subjects. All content provided in this blog, website, or any linked materials, including text, graphics, images, patient profiles, outcomes, and information, are not intended and should not be considered or used as a substitute for medical advice, diagnosis, or treatment. Please always consult with a professional and certified healthcare provider to discuss if a treatment is right for you.

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Insurance typically covers evaluations and diagnostic testing (if recommended). Most insurance plans currently do not cover Regenexx Procedures.

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Riverside Biologics Health Review: At Home "Stem Cells ...

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