Newswise Irvine, Calif., Oct. 22, 2021 A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.

Findings from the study, titled NAAA-regulated lipid signaling governs the transition from acute to chronic pain, published today in Science Advances, show that disabling N-acylethanolamine acid amidase (NAAA)an intracellularenzymein the spinal cord during a 72-hour time window following peripheral tissue injury halts chronic pain development in male and female mice.

Delineating the nature, localization and timing of the events involved in pain chronicity is necessary to pinpointing control nodes in the process that can be targeted by new classes of disease-modifying medicines beyond analgesics, said Daniele Piomelli, Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology. This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain.

Chronic pain evolves from acute pain caused by the physical trauma of tissue damage due to surgery or injury and is a massive problem, affecting more than 1.5 billion people worldwide. Chronic pain continues long past tissue healing, is often resistant to therapy, and remains seriously undertreated. Treatment is largely dependent on a handful of analgesic drug classes such as opioids, which may lose effectiveness over time and can also lead to addiction. Nerve damage is considered to be a critical factor in the transition to chronic pain, but the underlying molecular events leading to its emergence have been poorly understood.

Our findings suggest a new class of drugs NAAA inhibitors can be used to treat various forms of chronic pain and in preventing incisional and inflammatory injuries following surgery, Piomelli said.

This work was funded by grants R41NS106999, R42DA033683 and DA041229 from the National Institutes of Health.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an MD; a dual MD/PhD medical scientist training program; and PhDs and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an MD/MBA., an MD/masters in public health, or an MD/masters degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

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UCI-led study first to reveal specific molecular mechanism that controls the transition from acute to chronic pain - Newswise

When you're preparing to bake, you probably head straight for your pantry for the bulk of your recipe's ingredients. Yet experts warn that there's one common baking ingredient that you should never store in your pantry. That's because this one food runs a high risk of going rancid when stored improperlyleading to tainted flavors and, in some cases, health issues as well. Read on to find out which common pantry item you're likely storing wrong and how to spot a problem with this popular ingredient.

RELATED:If You Notice This on a Potato, Don't Eat It, Experts Warn.

While you may think nothing of putting a bag of flour in your cabinet or pantry until you need it again, experts say that it's a major mistake to store whole grain flour in either of these spots. That's because this type of flour is prone to rancidity, meaning it will go bad much faster if it's left unrefrigerated.

"When grains are ground, their interiors are exposed to the air," Harold McGee, PhD, a food scientist and author, tells The Chicago Tribune. "The whole grains contain the germ and the bran, both of which are rich in oils that are especially prone to oxidizing and going rancid. So you end up with off flavors very quickly in whole grain flours compared to refined flours," he explained.

RELATED:If You Notice This on Your Eggs, Throw Them Out Immediately, Experts Say.

In addition to refrigerating whole grain flour, you'd be wise to refrigerate any open packaged foods that contain whole grain flour, like cookies, crackers, and cakes. The oils found in these foods are also prone to rapid rancidityespecially when they contain polyunsaturated oils, such as nut oil or olive oils.

"Healthy" packaged snacks often include these ingredients, given that they're often considered nutritionally superior to refined white flour and saturated fats or trans fats. While they may be better for your body, their shelf life is significantly shorter than snacks that used refined flours and vegetable oils.

Part of the problem is that many Americans have become accustomed to the taste and smell of rancidity. Experts say that one way to lower your odds of eating a rancid food is to train your nose to recognize its smell. "We assume that rancid flavors are normal," McGee says, "because, in some cases, that's what we've gotten used to."

So what should you look out for? Integrative medicine specialist Andrew Weil, MD, told The Chicago Tribune that rancid food often gives off "the smell of oil paint," however faintly. "Linseed oil, which is the same as flax oil, is the basis of oil paint. It's highly unsaturated and so it oxidizes fast when exposed to the air," he explains.

For more food safety tips sent directly to your inbox, sign up for our daily newsletter.

Though whole grain flour may go bad faster than its refined counterpart, that doesn't mean you should stop buying it. There are several things you can do to keep this baking ingredient fresher for longer.

First, only buy what you need. Unless you bake daily, this means you probably want to opt for the smallest package available. Second, seal your leftovers in an airtight container or bag and refrigerate them. Finally, if you do choose to keep your whole grain flour in the pantry, always be sure to transfer it from its original paper bag to an airtight glass or plastic container. Keep it in a cool, dry, dark place until use, and always check for signs of spoilage before using it in your next recipe.

RELATED:Never Eat Microwaved Food Before Doing This, FDA Warns.

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Never Put This Common Baking Ingredient in Your Pantry, Experts Warn Best Life - Best Life

Founded in 2018, Medfuture, has quickly established itself in Quebec as the leader in home blood collection services, following the acquisition of Myrrha Sant in February 2019. The company, which aims to position itself as a key player in the field of preventive health, has since multiplied its initiatives by diversifying its product and service offering, taking advantage of technological advances in the field of biotechnology.

By the age of 35, many of the functions that are essential to everyday life begin to decline, at different rates for different people and with different consequences. Genetic, environmental and lifestyle components - diet, physical activity, smoking, sleep hygiene - are involved in this aging process, which can lead to chronic diseases, cancers, and other disabling conditions.

"We are currently observing a worldwide trend in favor of prevention in the health field. Some countries are even in the process of identifying aging as a disease on which we will be able to act and thus, reduce the costs of care in the public health system," says Amlie Paquette, Executive Director of Medfuture. "With the help of technological innovations developed in recent years, it is now possible to measure several biomarkers of aging, to create individual aging scores and thus, to assess the impact of interventions designed to modify the trajectory of aging of a person to make it more favorable."

The Agemeter Vitality Index is an innovative test developed in collaboration with a team of physicians and researchers who are experts in the non-invasive evaluation of aging. Deployed on a mobile application and lasting about 20 minutes, it is composed of six tests, associated with functions that decline with age: memory, hearing, decision making time, reaction time, movement speed and coordination.

Medfuture also announces that it will make its customer portal available in early 2022; this portal will offer customers a dashboard of past blood work history. This dashboard will show trends and trajectories of each biomarker at a glance and thus, adjust customers' action plans to act preventively.

The longevity industry, estimated at $17 trillion, is exploding, and the market opportunity will reach $27 trillion by 2026, according to experts. The fields of integrative medicine, gerosciences, nutraceuticals, regenerative medicine, gene therapies and connected health are gaining momentum, mainly due to advances in artificial intelligence, biotechnologies, nanotechnologies, robotics and cognitive sciences.

About Medfuture Clinic Inc.Medfuture specializes in the longevity field by helping people who actively seek control over their health, their most precious possession, to live an optimal and long life. Medfuture is a facilitator that aims to slow, stop or reverse the consequences of aging using tools to measure biomarkers related to the processes involved and concrete preventive actions, all with the use of advanced technologies and the practice of personalized medicine. Medfuture's multidisciplinary team offers a unique, human-centered experience.

For more information, visit https://medfuture.ca/pages/agemeter-indice-de-vitalite

SOURCE Clinique Medfuture Inc.

For further information: Alexandra Audy, [emailprotected], 514-378-7000 # 4487

https://medfuture.ca/

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MedFuture announces the launch of the Agemeter Vitality Index - Canada NewsWire

Like many other overweight Bangladeshi teenagers, I too, was relentlessly fat shamed out of "concern for my health" by everyone. From relatives to peers, it seemed like everyone had something to say. So, I decided to throw in the towel and surrender to a series of unfortunate attempts at dieting.

I say unfortunate because the Bangladeshi "dieting" scene revolves around handing out a pre-made or slightly customised diet plan that lists what you must eat and what you must avoid, and when. My numerous attempts at losing weight told me how many almonds to eat a day but did not tell me why I keep finding myself binge eating whenever I am stressed.

Our unhealthy eating habits and, in extreme cases, eating disorders, are greatly impacted by emotional and psychological factors. Furthermore, many people struggling to maintain a healthy weight through dieting may be emotional eaters. Emotional eating is a condition where the person suffering from it tends to eat whenever they feel fluctuations in their emotional state.

In my experience of going through a whole host of dieticians over the years, not one person mentioned my emotional well-being while dieting, or referred to my relationship with food. Never did they mention that my relationship with food might not be improving because I have mental blocks that I need to overcome. Instead, they told me that "I am bad at dieting."

When I pointed out to them that I might be an emotional eater and asked for advice, it was dismissed with an offhand comment along the lines of, "Oh, everyone is an emotional eater, it's all about will power so just stick to the diet."

Stick to the diet, they said. However, is it reasonable to expect someone to follow a strict diet when the person in question cannot make a distinction between emotional eating and eating out of genuine hunger?

Although people seem to be becoming more health conscious day-by-day, the general understanding of following a diet plan in Bangladesh often includes skipping meals to "lose weight." Therefore, in a typical Bangladeshi dieting scene, with its preconceived notion that people struggling with weight issues are just lazy and lack will power, there is also a lack of emotional support for people who are seeking to make changes in their lifestyles and eating habits.

Diane Robinson, Ph.D., a neuropsychologist, and program director of Integrative Medicine at Orlando Health said in her interview with PsychCentral that, "Most people focus almost entirely on the physical aspects of weight loss, like diet and exercise. But there is an emotional component to food that the vast majority of people simply overlook, and it can quickly sabotage their efforts."

While some dieticians are ignorant of the emotional aspect of dieting, on the other side of the spectrum, there are some dieticians who use "eating disorder" as an excuse for their failing diet plans without a proper psychological assessment.

Tasnim Nishat Islam, a 23-year-old university student going through a weight loss journey says, "When my weight didn't change after a few months of dieting, I was told it was because of mental issues although the dietician herself was not a psychologist, nor did she conduct a proper assessment to find out."

Sabekun Nahar Mumu, a practicing dietician at Evercare Hospital Dhaka says, "Certified dieticians in Bangladesh are trained on patient counselling but the training is not extensive or practical enough for them to treat patients with eating disorders. They are expected to refer such patients to a psychologist. The problem here is that the number of psychologists in Bangladesh who deal with eating disorders is not sufficient."

People who go to dieticians are often people who have experienced body shaming to some extent and are sensitive to judgmental comments. This is why it is especially important that practicing dieticians take the emotional side of dieting more seriously, so that people do not end up being misdiagnosed or have their concerns dismissed without assessment.

Tunzida Yousuf Chhonda, Managing Director and CEO at Cfitz women's fitness centre, who also works as a fitness expert, mentions, "Well reputed dieticians have the psychological training necessary to deal with emotional eaters. However, I have my doubts that some may not be as adequately equipped or trained as others. This needs to change, whether it is a curricular issue or a training issue, the field needs to adopt the psychological effects of emotional eating into its territory."

Mumu also points out that although graduates from food and nutrition who go into the clinical side are given training through an internship period, it is not widely available or enforced everywhere.

For this field to take into consideration the emotional and psychological side of dieting, it is imperative for dieticians to receive better training and practice empathy towards the clients they help. Otherwise, they may end up doing more harm than good.

References

1. PsychCentral. (December 2, 2015). Emotional Part of Weight Loss Often Overlooked.

2. PubMed. (March 26, 2020).

Emotional eating and obesity in adults: the role of depression, sleep, and genes.

When Tazreen is not pretending to be a high-brow literary critic, she quite likes Rupi Kaur's poetry collections. Send verbal eye-rolls at tazreenzahan@gmail.com

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The Emotional Side of Dieting - The Daily Star

image:The VPI10463 and M68 represent the classic and the hypervirulent C. difficile, respectively. GTD-VPI preferentially modifies Rho family GTPases (Cdc42, for example) by glucosylation, while GTD-M68 more effectively modifies R-Ras. Due to their different selectivity toward Rho or Ras family GTPases, these two different TcdB variants cause two distinct types of cytopathic effects. view more

Credit: UCI School of Medicine

Irvine, Calif., Oct. 22, 2021 A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease.

Based on their findings that established the structural basis for Toxin B recognition of the small GTPases Rho and R-Ras families, the study, titled Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, was published today in Sciences Advances.

CDI is the leading cause of antibiotic-associated diarrhea and gastroenteritis-associated deaths worldwide, accounting for 500,000 cases and 29,000 deaths annually in the U.S. Classified by the Centers for Disease Control and Prevention as one of the top health threats. There is growing global concern surrounding the emerge and spread of hypervirulent C. difficile strains, resembling the occurrence of new virus variants in current COVID pandemic. TcdB is one of two homologous C. difficile exotoxins, and TcdB alone is capable of causing the full spectrum of CDI diseases.

We focused on the structure and function of TcdBs crucial GTD, which is the toxins warhead. The GTD is delivered by the toxin inside the host cells and causes most of the cytosolic damage to patients, said Rongsheng Jin, PhD, professor in the Department of Physiology & Biophysics at the UCI School of Medicine, and corresponding author. We discovered molecular mechanisms by which the GTD specifically recognizes and blocks the physiological functions of the human GTPases Rho and R-Ras enzyme families that are crucial signaling molecules.

The team also demonstrated how the classic form of TcdB and the hypervirulent TcdB recognize their human targets in different ways, which leads to distinct structural changes to the host cells caused by bacterial invasion.

Once the GTD of TcdB is inside the cells, it is shielded by our cells and becomes inaccessible to passive immunotherapy. But our studies suggest that small molecule inhibitors could be developed to disarm the GTD, which will directly eliminate the root cause of disease symptoms and cellular damage, Jin said. This new strategy can potentially be integrated with and complement other CDI treatment regiments.

This work was supported by the National Institutes of Health under awards R01AI125704, R21AI139690, R21AI123920, R01NS080833, R01AI132387, R01AI139087 and R21 CA235533.

Team members also include Zheng Liu and Peng Chen from the UCI Department of Physiology & Biophysics; Sical Chang, Songhai Tian, Ji Zeng, and Min Dong, Department of Urology, Boston Childrens Hospital, and Department of Microbiology and Surgery, Harvard Medical School, Boston; and Kay Perry, NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York; and Argonne National Laboratory, Lemont, Illinois.

About the UCI School of Medicine: Each year, the UCI School of Medicine educates more than 400 medical students, and nearly 150 doctoral and masters students. More than 700 residents and fellows are trained at UCI Medical Center and affiliated institutions. The School of Medicine offers an M.D.; a dual M.D./Ph.D. medical scientist training program; and Ph.D.s and masters degrees in anatomy and neurobiology, biomedical sciences, genetic counseling, epidemiology, environmental health sciences, pathology, pharmacology, physiology and biophysics, and translational sciences. Medical students also may pursue an M.D./M.B.A., an M.D./masters in public health, or an M.D./masters degree through one of three mission-based programs: Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), Leadership Education to Advance Diversity-African, Black and Caribbean (LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit som.uci.edu.

Experimental study

Cells

Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B

22-Oct-2021

Authors declare that they have no competing interests.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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UCI-led study suggests new molecular target for therapeutic interventions aimed at C. difficile infection - EurekAlert

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The food you eat can help or hurt your skin health.

"Damp" foods like dairy and oils, as well as refined carbs and sugars, have been linked to acne.

Good fats - in avocados, nuts, and fish - and fiber are essential for healthy skin.

The idea of healing your skin through what you eat is not a new one.

Eastern systems of medicine, like the Chinese and Ayurvedic traditions, have long theorized that "damp" foods, such as dairy and oil, can cause problems with skin, Dr. Taz Bhatia said at the Environmental Working Group's annual CleanCon.

But it bears reminding that what you put in your body matters just as much as the products you put on your face, Bhatia - a doctor who is board-certified in holistic and integrative medicine - said in a discussion about skincare at CleanCon.

Modern life, Bhatia said, has given us too many options to choose from on both fronts, with harmful additives galore.

After running through some tips for buying non-toxic beauty products, Bhatia recommended some dietary themes for keeping skin clean and healthy. Here are a couple of food groups to avoid, and some others that may benefit your skin.

The old Chinese theory about dampness may have some truth to it. Many of the foods considered to be damp - like cheese, greasy chips, and egg yolks, Chinese medicine expert Mona Dan told Well + Good - have the potential to affect skin.

Dairy consumption has been linked to an increased risk of acne, although there's no evidence that eliminating dairy will improve skin. Some dairy products contain the hormone insulin-like growth factor (IGF-1), which can spur oil production and worsen acne.

Foods containing oils and saturated fats can also lead to increased inflammation in the body. Inflammation underlies several skin conditions, including acne, eczema, and rosacea.

However, some tenets of traditional Chinese medicine don't line up with what we know about skin health today. For instance, raw fruits and veggies are considered "damp," but they contain essential antioxidants for skin in higher concentrations than their cooked counterparts.

Story continues

Refined carbohydrates - basically all the bread, pasta, and sweets you would expect to be unhealthy - have been linked to acne time and time again.

People with acne tend to consume more refined carbs than those with clear skin, studies have found.

Binging on sweets is especially tied to acne risk; one study found that people who frequently consumed added sugars had a 30% greater risk of developing acne. This may have to do with how refined carbs cause blood sugar and insulin to spike, which also leads to increased IGF-1.

Although some oily foods may mess with your skin, it's important to incorporate some healthy fats and oils into your diet.

Healthy fats - such as unsaturated fats and omega-3 fatty acids - are essential for keeping your skin plump and glowing.

You can use the Mediterranean diet to guide your choices of health fats and oils. Foods like avocados, olive oil, salmon, and tuna are known to contain unsaturated fats and/or omega-3 fatty acids, which may help fight inflammation.

Fiber is essential for keeping your bowel movements regular, lowering bad cholesterol, and feeling full for longer. On top of that, maintaining a healthy gut is a shortcut to healthy skin.

Poor gut health has been linked to increased inflammation, which in turn can exacerbate skin conditions like acne and dryness.

What's more, fiber helps your digestive system better absorb nutrients and antioxidants that may help your skin and overall health. If you've been loading up on nutrients like vitamin C and collagen while skimping on fiber, your skin might not be getting the full benefits.

Prebiotic fiber - which can be found in foods like bananas, artichokes, onions, garlic, and whole grains - is best for supporting a healthy microbiome and positively impacting skin.

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Avoid 'damp' foods if you're prone to breakouts, and try healthy fats to clear up your skin - Yahoo News

PHILADELPHIA, Oct. 26, 2021 /PRNewswire-PRWeb/ --Signaling the world's vulnerability to disease, the School of Veterinary Medicine at the University of Pennsylvania (Penn Vet) is launching the Institute for Infectious and Zoonotic Diseases (IIZD) to confront emerging and re-emerging zoonotic and vector-borne diseases, with a goal of fostering innovations in disease surveillance, treatment, and vaccine development.

With 75% of all newly emerging infectious diseases being zoonotic, there is an alarming and urgent need for early detection and prevention of these threats. The new Institute will rapidly scale up research on infectious agents and summon Penn Vet's extensive bench to tackle new or re-emerging disease. The Institute will have a particular focus on diseases within the northeastern United States. With four major ports of entry, and a population of more than 64 million people, the region is exceedingly vulnerable to spillover of disease between animals and humans; and across rural, agricultural, suburban, and urban landscapes.

The Institute mobilizes 30 Penn Vet faculty, 110 research investigators, and Penn affiliate faculty on broadening the understanding of viral, bacterial, and parasitic pathogens; vector biology; antimicrobial resistance; immune response; the role of wildlife and the environment; as well as antivirals and vaccines. The Institute's new Martin and Pamela Winter Infectious Disease Fellowship will provide support to graduate students focusing on infectious diseases of animals and humans; and the Institute's pilot grant program will fund research that supports infection diagnosis, surveillance, or treatments.

The Institute is led by Christopher Hunter, PhD, Mindy Halikman Heyer Distinguished Professor of Pathobiology who has advanced the understanding of cytokine networks in regulating immune responses to inflammation and infection.

"The public's awareness of infectious diseases has never been higher; the COVID pandemic has made it clear that there is an imperative to expand our focus to local and global infectious diseases," said Hunter. "This Institute represents a steadfast commitment to protect populations against deadly animal and human health threats such as rabies, West Nile virus, Lyme disease, and COVID-19."

"We have one of the largest zoonotic disease programs in the world. Bringing that expertise to bear on regional disease outbreaks gives us a significant geographic advantage in mitigating health risks that are literally in our own backyard," said Andrew Hoffman, DVM, DVSc, DACVIM, the Gilbert S. Kahn Dean of Veterinary Medicine. "The Institute will allow us to integrate communications across our veterinary health networks, respond to disease impacts in real time, and truly transform public health for the communities and economies that we serve."

The Institute's core leadership team, led by Hunter as inaugural director, includes De'Broski Herbert, PhD; Lisa Murphy, VMD; Dan Beiting, PhD; and Julie Ellis, PhD. The team will provide an ongoing source of integrative leadership and coordination for the Institute's research and outreach agendas, educational priorities, and disease response.

To learn more about the new Institute for Infectious and Zoonotic Diseases, visit http://www.vet.upenn.edu/IIZD.

Media Contact

Martin Hackett, University of Pennsylvania, +1 2158981475, mhackett@vet.upenn.edu

SOURCE University of Pennsylvania

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University of Pennsylvania's School of Veterinary Medicine Establishes Institute for Infectious and Zoonotic Diseases - The Wellsboro Gazette

The NFL's reigning MVP isn't likely to unseat book club queens Oprah Winfrey, Reese Witherspoon orJenna Bush Hager anytime soon, but his Aaron Rodgers Book Club is rolling right along.

Each Tuesday during his appearance on "The Pat McAfee Show," the Green Bay Packers quarterback ends his segment by revealing a recommended book. An avidreader, Rodgers told McAfee he started thinking about the idea after Packers wide receiver Marquez Valdes-Scantling asked him for a starter packof recommended reads during training camp.

His inaugural book club pick, "The Alchemist," got a retweet from its author. Rodgers has saidhe's heard from others who have thanked himfor talking about reading.

"We need more people reading and (less) people spending time sitting on their ass watching TV and other bull----," hesaid on the show.

Brown CountyLibrary, which has nine locations in greater Green Bay, has noticed an uptick in interest in the titles Rodgers has recommended to date, particularly since October, said Susan Lagerman, the library's community engagement manager. Several of the titles are checked out and others have waiting lists, she said.

Rodgers, who told McAfee he has a stack of 30 books he wants to get to, reads mostly nonfiction and leans toward philosophical, spiritual and self-help titles. He plans to choose 18 books through the season.

All proceeds from the saleof Aaron Rodgers Book ClubT-shirts through McAfee's online merchandise store will be donated to a reading advocacy program of Rodgers' choice.

Here's a breakdown of his picks so far:

Recommended on: Oct. 26

Quick summary:Tolle, aGerman-born spiritual teacher, on how living in the now offersthe truest path to happiness and a harmonious life. He wrote the manual in response to questions asked of himin seminars, meditation classes and private counseling sessions. For that reason, it uses a question-and-answer format. Chapters cover such topics as creative use of mind, inner body, enlightened relationships and state of presence. After certain passages, apause symbol encourages readers to take a break, be still and think about what they read.

Rodgers' take: "It's a fantastic book for anybody interested in what a spiritual practice looks like, how to better understand their mind, how to quiet your mind, mindfulness." If you liked Rodgers' earlier pick, "Be Here Now" by Ram Dass, you might like this one. He said they're quite similar.

Recommended on: Oct. 19 (two days after the "I still own you" Packers-Chicago Bears game)

Quick summary: Writtenmore than 2,000 years ago in ancient China, it's the first known study of the planning and conduct of military operations, but its reach extends beyond battlefield maneuvers to business, politics and personal conflicts. Among the classic'sfamed quotes:It is easy to love your friend, but sometimes the hardest lesson to learn is to love your enemy."

Rodgers' take: "It's a book that I think most great leaders have read at some point ... A lot of great wisdom in here and one-liners that you can use in your life and in press conferences down the road as well and in speeches to your team when you're trying to fire up the boys."

Recommended on: Oct. 12

Quick summary:Chopra, world-renowned as an author and speaker on integrative medicine and personal transformation,teams up with physicist Menas Kafatos to explore questions about time, space, the universe and humans' place in it.

Rodgers' take:He just finished reading the 2017 book and admits it's "a super dense book" with "some crazy concepts." At 288 pages, it's also one of the longer books he has chosen.

Recommended on: Oct. 5

Quick summary: First published in 1997, the long-running New York Times bestseller explores four agreements people can make with themselves to find happiness and freedom. They are: Be impeccable with your word; don't take anything personally; don't make assumptions; and always do your best.Winfrey has heralded the book three times on her television shows, in 2000, 2001 and 2013, resulting in huge sales spikes each time.

Rodgers' take: It's his go-to title when someone hits him up for a self-help book recommendation. It's a simple read at 140 pages and one he thinks everyone can relate to, especially the agreement about not to take thingspersonally.

"I think that'sthe motivation for most comments on social media," Rodgers said. "Somebody has said something and then somebody takes it personally and then they have to fire back."

RELATED: A full fridge and bidets: Randall Cobb talks about the perks of staying at Aaron Rodgers house

RELATED: Comedian Bert Kreischer hangs out with Aaron Rodgers, squeezes into tiny Packers jersey

Recommended on: Sept. 28

Quick summary: A 1971 book that offers guidance on meditation, yogaand finding your true self from the famed guru of the spiritual movement in America. It took off during the hippie movement in the '70s, offering readers a way to find peace, calmness andhigher states of consciousness without psychedelics and deliveringthe ultimate message tolive in the present.

Rodgers' take:"It's a good intro book, I think, for anybody interested in needing inspiration on their journey to a new type of spirituality. Some incredible quotes in here and a book that really meant a lot to me."

Honorary mention:It's not an official ARBC selection, but Rodgers did give a shoutout to"Chuck Norris CannotBe Stopped:400 All-New Facts About the Man Who Knows Neither Fear Nor Mercy" by Ian Spector, mostly because he ran across a copy on his home bookshelf.

Recommended on: Sept. 21

Quick summary: TheAmericanyoung adultnovel follows 12-year-old Jonas in a society that at first appears to beutopianbut is later revealed to bedystopianas the haunting story goes on. It won the 1994 Newbery Medal, awarded annually by the American Library Associationfor the most distinguished American children's book published the previous year.

Rodgers' take: "This book was on reading lists when I was growing up. It still stands up. It's, in my opinion, super relatable to what we're going through as a society now." Rodgers has read it four times.

Recommended on: Sept. 14

Quick summary: The story of the Arizona Cardinals safety who gave up a $3.6 million contractafter 9/11 to enlist in the U.S. Army and become an Army Ranger. Sent first to Iraq and then Afghanistan, Tillman was killed in 2004 by friendly fire, the details of whichwerekept from his family and the American public for several weeks after his death.

Rodgers' take: "One of my legitimate all-time favorites by an author who I have read many, many of his books."

Rodgers said he has given the book away so many times for others to read that he had to run to Barnes & Noble to pick up a copy for the segment.

"The best part about it is learning more about Pat Tillman, and Pat, which I didn't know, he's a deep thinker and, like myself, kind of grew up in and around the church but at some point really dove into Eastern religions and meditationand philosophyand journaling. He was a very curious guy and he had a lot of interests outside of football."

Recommended on: Sept. 7

Quick summary: First published in 1988, the international bestseller by the Brazilian author tells thestory of an Andalusian shepherd boy who yearns to travel in search of a worldly treasure. His quest ends up taking him to riches of a different kind. No. 70 on the list of 100 most-loved books from PBS' "The Great American Read,"itoffers lessons about listening to your heart, recognizing opportunity and following your dreams.

Rodgers' take:"One of my all-time favorite books, and it's an easy book, and it'sfiction, which, I don't read a lot of fiction, but it's been around for a long, long time."

Rodgers, who just finished reading itagain during training camp, highlighted some of his favorite excerpts with a blue marker somethinghe often does with books he reads.

ContactKendra Meinertat 920-431-8347 or kmeinert@greenbay.gannett.com. Follow her on Twitter @KendraMeinert.

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Are you keeping up with the Aaron Rodgers Book Club? Here are all of his recommended reads so far, including the latest 'The Power of Now.' - Green...

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Global Integrative Health or Complementary and Alternative Medicine Market 2021 Growing Opportunity and Competitive landscape Arab Yoga Foundation...

Turning 40 feels like a milestone and, with life expectancy still hovering around 81 years for adults in the UK, it does indeed mark a halfway point. Undeniably, the body starts to work against us as we enter midlife and not just by making those unwelcome grunts when we ease into an armchair.

The risk of cancer starts to increase, as the cells become more damaged over time; for women the perimenopause may begin at this stage. Meanwhile, our body composition changes after the age of 30 we lose around 3-5 per cent of muscle per decade unless we include strength training in our regimes, and midlifers can find their waistline expanding, though whether this is down to the metabolism slowing down, or an increased cheese and wine habit, remains the subject of debate.

But lots of these downsides of ageing can be managed or even prevented by lifestyle tweaks; studies show that adopting healthy habits can decrease cancer risk by as much as 40 per cent. So if youre in your 40s, one of the best things you can do is have a health check.

From the age of 40, a full health screening should be a key date in your diary each year, Dr Ursula Levine, General Practitioner (Integrative Medicine), at Lanserhof at The Arts Club says. The earlier a change in your health is detected, the more efficient the treatment can be.

The NHS offer a free health check for over-40s every five years to check for early signs of stroke, kidney disease, heart disease, type 2 diabetes or dementia. But there are plenty of tests you can do at home, too...

Leading diabetes scientist Dr Roy Taylor recently said not being able to fit into the trousers you wore in your 20s can be a sign you are carrying too much fat and at risk of type 2 diabetes.

Waist size is an important indicator of health because fat stored around the middle can be especially harmful, building up around organs such as the liver and pancreas and raising the risk of insulin resistance and metabolic and cardiovascular disease.

But the jean size test is a bit rudimentary. Dr Michael Mosley, who created the 5:2 diet, has a different marker of good health. We know the waist to height ratio is a useful indicator of health ideally your waist circumference should be at most half of your height, he says. But you dont need a tape measure just grab a piece of string that is as long as you are tall. Fold it in half and see if it fits around your waist.

If it doesnt, dont panic, but it is something to work on. Reducing your waist circumference to half your height will likely improve your long-term health and boost your immunity, Dr Mosley adds.

If you want a quick test to see how your heart is coping, climb four flights of stairs (60 steps) and time yourself. If it takes you more than one-and-a-half minutes to ascend four flights of stairs, your health is sub-optimal, and it would be a good idea to consult a doctor, says Dr Jess Peteiro, a cardiologist at University Hospital A Corua, Spain, who presented his research at the European Society of Cardiology conference last year.

A recent study published in the journal Jama Network Open found that getting fit in your 40s and 50s lowers the risk of early death by about 35 per cent and is particularly protective against heart disease.

Women of all ages but particularly those in their 40s and upwards should check their breasts regularly. Dr Zoe Williams, the GP and broadcaster, recommends doing this ideally once a month and says that its not just lumps we should look out for. There are many different signs such as irritation or dimpling of the skin on the breast or flaky skin in the nipple area, she says. If you notice any unusual changes, its important to contact your GP as soon as possible.

Breast cancer screening is offered on the NHS from the age of 50. It is not recommended before then because theres not enough evidence that it would reduce deaths, and the tests have risks as well, says Sophia Lowes at Cancer Research UK.

Other red flag symptoms to have investigated include unusual lumps anywhere on your body, appetite loss, heavy night sweats and blood in stools. If you do notice something unusual, tell your doctor, Lowes says.

The ability to balance on one leg is a strong indicator of longevity and health, according to a study by the Medical Research Council, which tracked 5,000 people born in 1946 throughout their lives. Those who could balance on one leg for more than 10 seconds with eyes closed, and then to stand up and sit down in a chair 37 times in 60 seconds or 35 times for women tended to have a better life expectancy when they revisited them 13 years later.

Balance is something we take for granted, Dr Mosley says. It enables you to move confidently through life but unfortunately, our balance deteriorates when you hit your 40s. The brain uses messages from receptors in our inner ear, eyes, muscles and joints to keep us upright. If our balance is off, it can be an overall marker of decline of brain health.

Practising standing on one leg once a day is a simple way to improve your posture and balance. When Im brushing my teeth, I set a timer, and stand on one leg, switching from one leg to the other. Each day, try and increase the number of seconds and try and work up to a minute if possible, says Dr Mosley.

Nearly 40 per cent of adults have high or borderline high cholesterol, according to NHS statistics, and levels increase with age. The NHS advises asking for a test if you are 40 and over and havent had a test before, especially if high cholesterol or heart problems run in your family. High cholesterol has no symptoms, so the only way to tell is a blood test.

Blood pressure also rises with age, thanks to a reduction in elastic tissue in your arteries, and again it can be symptomless. Around 90 per cent of patients have no symptoms, says Dr Nighat Arif, a GP based in Buckinghamshire. But high blood pressure can have life changing effects, such as triggering a heart attack or stroke, damaging your kidneys or even losing your vision.

Women in particular need to be aware of raised blood pressure; researchers from Norway reported earlier this year that even slightly elevated readings from the age of 40 were a strong risk factor for a heart attack in the next 16 years.

170,000 Britons die a year due to heart attacks, strokes and circulatory conditions, according to Cambridge University research, and cutting your cholesterol and blood pressure through quitting smoking, exercising, losing weight and reducing salt can reduce the risk by four fifths.

Spinal degeneration and back problems become more common after the age of 40, says osteopath Nadia Alibhai. To protect the long term health of your back, she says keeping flexible is absolutely key.

In an ideal world, we should be able to touch our toes in our 40s, as it displays flexibility in your lower back, glutes, ankles and hamstrings. Flexibility is needed for proper blood circulation and muscle elasticity; touching the toes helps prevent muscles from contracting and becoming short and tight.

A study published in the journal Heart and Circulatory Physiology found that being able to touch your toes could mean that your arteries are in good shape, too. Researchers found a correlation between poor flexibility and atherosclerosis in a group of people aged 40 and above.

If you cant get down that far, you need to practise. If youre struggling, start with a slow forward fold, Alibhai says. Stretch upwards and lengthen your spine before folding forwards. Keep your spine straight and if you need to bend your knees, please do. Dont push yourself too far, slow and steady wins the race.

Im seeing so many people with back problems at the moment, says Dr Arif, and they are usually posture related from hunching over screens. If you know you can touch your toes, then you are extending the spinal cord and sciatic nerve and you know youve got good flexibility.

Your GP is trained to check moles, and you can ask them to do just that. However: I would always recommend getting a regular (once yearly) mole check at a specialist clinic once you turn 40, says Dr David Jack, an aesthetic doctor and skincare expert. Specialist mole clinics do this every day so if there is something unusual that might not be recognised by a GP then it can be quickly diagnosed and treated right away.

For Dr Michael Mosleys recipes to help with weight loss visit http://www.thefast800.com

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Seven health checks to have once you turn 40 - Telegraph.co.uk