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Overview of the Latest DHHS HIV Treatment Guidelines – Healthline

Posted: July 21, 2021 at 2:44 am

The Department of Health and Human Services (DHHS) is the U.S. federal government agency responsible for protecting the health of the American public.

The DHHS HIV guidelines help inform healthcare professionals of the best ways to treat HIV based on the latest clinical evidence and expert opinions.

In this article, we break down some of the key points of the DHHS guidelines and what to know about the most recent changes.

The main goal of the DHHS guidelines is to offer recommendations to healthcare professionals on the best treatment options for people with HIV. The guidelines are written and updated based on the most recent scientific evidence.

Doctors can consult these guidelines to determine the right treatment at various stages of HIV. For example, the guidelines provide recommendations on when to start antiretroviral therapy (ART), which drugs should be used, and what to do if initial treatment isnt working.

The full guidelines provide a long list of recommendations you can read here. Weve summarized some key points below so you can get an idea of the type of information these guidelines include.

Initial HIV treatment generally consists of two medications called nucleoside reverse transcriptase inhibitors in combination with a third active antiretroviral (ARV) drug from one of three drug classes:

The following drug regimens are classified as recommended initial regimens for most people with HIV. A slash (/) between medications means theyre available as a combination drug within the same pill:

When ART isnt working, several factors should be considered, including:

At the time this article was written, the DHHS guidelines were most recently updated on June 3, 2021.

Researchers are continuing to improve their understanding of how to best treat and manage HIV. The guidelines are updated periodically to include the latest research and expert opinions.

Heres an overview of the most recent changes included in the 2021 update.

New evidence from the Botswana Tsepamo Study, an ongoing observational study that started in 2014, suggests that the rate of neural tube defects (a type of structural change in a developing fetus) is lower than expected in women taking dolutegravir at the time of conception.

Dolutegravir is now recommended as an initial treatment option for people who may get pregnant.

The medication raltegravir was moved from recommended initial regimens for most people with HIV to recommended initial regimen in certain clinical situations.

The change was partially made due to the results of the Botswana Tsepamo Study. Since dolutegravir is now a viable treatment for people who can get pregnant, its no longer necessary to choose raltegravir over dolutegravir.

It was initially recommended that if ART treatment doesnt work, it should be followed by two and preferably three fully active ARV drugs.

Its now recommended that the new treatment can include two fully active drugs if at least one has a high resistance barrier. Examples of such drugs include boosted darunavir or dolutegravir. The change was made based on the results of ongoing clinical trials.

Updates include the mechanism behind declining CD4 counts despite suppressive ART.

CD4 cells are a type of white blood that fights infections. Knowing a persons CD4 count helps determine their risk of developing opportunistic infections.

The new guidelines also include updated strategies to reduce persistent inflammation.

Updates include the role of long-acting injectable regimens cabotegravir plus rilpivirine. Long-acting injectables are a new form of ART that involve infrequent injections instead of daily oral medication.

The Food and Drug Administration (FDA) approved the first long-acting injectable for treating HIV in January 2021.

The adolescent and young adults section has been updated to include current data on the rate of HIV among youth in the United States.

The guidelines now also have more details on the unique challenges that youth with HIV face compared to adults.

This section now includes data from a 2020 review of eight studies that found that women are more likely to gain weight than men after starting ART.

Theres also now more information regarding the effects of menopause and hormone replacement therapy while on HIV treatment.

This section now includes information about when to consider the long-acting injectable cabotegravir plus rilpivirine in people with a substance use disorder.

Current research is limited to people with good medication adherence.

Newly discovered drug interactions have been included in the guidelines, including interactions between the drugs cabotegravir plus rilpivirine and fostemsavir.

A section was added discussing the cost effectiveness of new drugs, such as ibalizumab, in HIV thats resistant to multiple ARV drugs.

Monthly prices of commonly prescribed ARV drugs have been updated with 2021 prices.

Updates describe current recommendations for ARV drugs that can be used if 3 months of isoniazid and rifapentine are prescribed for tuberculosis.

There are many free or low-cost programs available to help people with HIV. Here are some resources that may be helpful:

The DDHS HIV guidelines were developed to help healthcare professionals stay up to date with the latest HIV research so they can provide the best possible treatment. The guidelines are updated regularly as new research or evidence becomes available.

The guidelines are available online for free to anybody who wants to read them.

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Global Hormone Replacement Therapy Market Technology Prospectus to 2027 Pfizer, BioSante Pharmaceuticals and Amgen, Noven Pharmaceuticals, Bayer AG …

Posted: July 21, 2021 at 2:44 am

Global Hormone Replacement Therapy Market Technology Prospectus to 2027 Pfizer, BioSante Pharmaceuticals and Amgen, Noven Pharmaceuticals, Bayer AG The latest report published by Zion Market Research provides the present and future growth prospects for the globalHormone Replacement Therapy Marketby a thorough understanding of the factors that are shaping the trends that are further driving the growth of the market in terms of region & segment, untapped market places, and revenue potential with the consumption pattern and demand of the product. Every section of the report is scoped with an in-depth analysis of the market and represented in a systematic data analysis framework for the forecast period of 2020-2026 for a better understanding of the market. The report on the global Hormone Replacement Therapy Market also incorporates the impact of the Covid-19 pandemic including the factors that have affected the market growth that will allow the investor to invest wisely as per the current trends to stay ahead in the market.

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Tips to Manage when You’re in Menopause with ADHD – PsychCentral.com

Posted: July 21, 2021 at 2:44 am

Living with ADHD while going through menopause can be challenging, but there are ways to manage both.

What do ADHD and menopause have in common other than mood changes and inattention?

Though some symptoms are observable on the outside, folks around you may not understand even half of what youre handling internally, let alone that youre managing both at the same time.

Living with attention deficit hyperactivity disorder (ADHD) comes with its own challenges. And if youre going through perimenopause or menopause, you may face more difficulties.

ADHD is a neurocognitive disorder that has three presentations:

People can receive a diagnosis early in childhood as well as late in life.

Dr. Ellen Littman, a clinical psychologist in New York state, explains that estrogen has powerful effects on brain chemistry throughout your lifetime.

Menopause is among the top biggest events to change estrogen in your body, among starting your period and becoming pregnant.

Estrogen is considered neuroprotective, in that high levels increase the availability of neurotransmitters (brain messengers) like dopamine and serotonin, which enhance cognition, mood, sleep, verbal memory, and even ADHD symptoms, Littman says, who is publishing an upcoming review article about the female hormonal effects on ADHD.

However, your levels of estrogen decline beginning in perimenopause and are spent during menopause.

While people face some symptoms off and on during menopause, Littman says those who also have ADHD experience intensified symptoms.

By understanding the relationship between menopause and increased ADHD symptoms, they are less likely to be ambushed by the amplified difficulties they experience, she says.

Both ADHD and menopause are known for patternless shifts in brain activity and hormone changes.

So, you might begin to see how overlapping symptoms happening concurrently or one after the other can worsen the experience of both conditions and make them difficult to manage.

A 2016 study even looks at the effectiveness of using ADHD medication to treat people experiencing executive function issues during menopause.

While going through menopause when you have ADHD can feel overwhelming, there are ways you can manage both conditions.

Finding a psychiatrist whos well versed and experienced in treating ADHD in people going through menopause can help you get the care you deserve.

While it might not be easy to find a psychiatrist with experience in this area, start by asking your current mental health professional or gynecologist for recommendations.

If you cant find a psychiatrist whos familiar with research demonstrating hormone involvement in ADHD symptoms, Littman suggests sharing information or articles (like this one) with them.

If you feel that your credibility is being questioned, its important to feel entitled to finding the clinician who best fits your needs, she says.

Littman suggests finding a gynecologist whos experienced in treating people going through menopause, and who will also work with the doctor who treats your ADHD.

Since women now spend about a third of their lives in menopause, it is critical to find a treatment regimen tailored to your specific needs, she says.

According to a 2019 survey of postgraduate resident trainees in family medicine, internal medicine, and obstetrics and gynecology in U.S. residency programs, only 6.8% of them reported feeling just adequately prepared to manage women experiencing menopause.

No one clinician is knowledgeable about all aspects of each individual experience, but Littman says finding doctors who will collaborate and communicate with your gynecologist can help tailor treatment.

For instance, if your ADHD medications need adjusting, as well as your decreasing estrogen levels, having both your gynecologist and doctor who treats your ADHD collaborate could help.

While pharmacologists often adjust the dosage to meet the new challenges, increased estrogen could address both menopausal and ADHD symptoms. Bioidentical hormone replacement therapy (HRT) is one route to increased estrogen for many women, Littman says.

Although your doctors may be hesitant to communicate with each other, being assertive and informing them of your conditions, as well as bringing information from each doctor to your appointments, can help ensure theyre in tune with whats going on with your body.

While theres a wide range of menopausal symptoms that occur on a continuum, Littman points out that ADHD can worsen symptoms like impaired cognition and mood.

In fact, a 2019 research paper suggests that ADHD symptoms, and even concurrent symptoms from other conditions, are also vulnerable to the hormonal changes experienced during menopause, says Littman.

Both conditions can muddle with your executive functions, a clinical term for your:

If you find that these areas of your life are becoming more difficult to manage, coming up with a plan to help navigate them can make your days easier.

For instance, if keeping and organizing appointments and commitments is difficult, setting an email calendar reminder so you get notifications on your phone, tablet, and desktop can help you stay on track.

If self-monitoring is a blind spot as of late, you could try leaning on your inner circle to gently give you a signal if agitation or strong emotions are coming off more than intended.

You might also look into present moment awareness to reconnect with mindfulness and strengthen your self-awareness.

In addition to seeing a professional, Littman suggests pursuing your own psychoeducation. Consider bookmarking the following resources:

The more you can understand about the relationship between your [brains response to ADHD] and your body in menopause, the more you can be an active participant in your treatment. And the more your support network understands about your challenges, the more supportive and compassionate they can be, Littman says.

While managing your ADHD while going through menopause can be challenging at times, there are ways to make the process easier.

Littman says that on the clinical front, new research brings hope for better treatments ahead.

Were on the brink of an exciting new understanding of the experience of women with ADHD, she says. As new studies continue to implicate the powerful role of hormones in womens experience of ADHD, the potential for more comprehensive and successful treatments may be on the horizon.

You can stay tuned for Littman and teams upcoming study on ADHD and estrogen, titled: ADHD in Females Across the Lifespan and the Role of Estrogen. It publishes August 2021 in The ADHD Report.

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No Shame In Wanting To Look Younger – It Is Natural And You Might As Well Live Longer – Forbes

Posted: July 21, 2021 at 2:44 am

The desire to look younger is natural

Like many other living organisms, humans are born, survive, compete for resources, reach maturity, reproduce, take care of their young, sometimes the young of their young, continuously decline, and die. Evolution needs us for just two purposes adapt and reproduce. But, unlike other species, humans are very conscious of their fate. Humans are very much aware that after reaching peak performance they will eventually grow old and die. We arevery conscious of our fate after reaching peak performance loss off function, frailty, and eventual loss of everything we worked so hard to earn.

We observe our parents, and other elderly around them, attend funerals, and understand that eventually we will get into this state. We are also very contempt with that fate as evolution made sure that. The more ambitious of us are trying to advance science, the rest seek refuge in religion, some in philosophy, some in accumulation of wealth, and some see the continuation of ourselves in our children. But despite the many technological advances transpiring in the laboratories all over the world, there is nothing we can do at this point to escape aging. There are diets, exercises, sleep, and supplements, but these provide very marginal benefits. We do not see 120+ old yoga and diet practitioners or marathon runners around. But these simple habits do help look younger longer. And many people that have very harmful habits like smoking but still diet and exercise to look younger.

Nature is also very unfair and sexist. The females lose reproductive capacity much faster then males. Most females enter menopause between 40 and 60. The average age of menopause in the US is 51. And it is very common to see the couples where the males are significantly older. And for this reason nature found its way to signal the reproductively active people that the older person is not someone they would like to copulate with. And there are many signals: graying hair, wrinkles, body composition, etc. There are few beauty contests for people over 25, and most fashion models become popular in their teenage years. Males can reproduce longer and often remain more attractive to younger females but the level of attractiveness is usually lower and often augmented by social and economic status. It also does seem like the younger women prefer older men more often then the other way around.

So looking younger is a natural desire just like it is natural to seek a younger spouse after a certain age. It is a desire to maintain reproductive viability.

And even though there are not that many aging processes that we can have any control of, the desire to look younger spurred a giant industry. Now it is technologically possible to shave a decade or even two off the way we look via cosmetic interventions, makeup, and surgery.

But whenever we see media images of older celebrities, particularly those who seem much younger than their actual age, the inevitable questions concerning whether "he/she had work done"" or snide remarks about too much botox/liposuction" are rarely far behind.

But why is there such a stigma about wanting to look younger?Despite all these often vicious remarks about cosmetic surgery and other attempts at looking young and attractive, it's not just celebrities who are doing this.While cosmetic surgery used to be reserved solely for the very rich, it is becoming much more affordable, and, not surprisingly, more people than ever are taking advantage.According to the 2019 Plastic Surgery Statistics report released by the American Society of Plastic Surgeons, more than eleven million surgical and nearly fourteen million non-surgical procedures took place worldwide last year, almost four million of those procedures in the United States alone.

Healthcare and medicine

While most cosmetic surgery patients are women,male patients are also becoming more common, and the demand for such services has steadily risen over the past decade.The primary market for women is routine procedures such as breast augmentation, rhinoplasty (nose reshaping), "tummy tucks," and dermabrasion.On the other hand,male patients are getting hair transplantation, breast reductions (or augmentation), calf and pectoral implants,penile extensions (where available), and various other improvements to make them look more masculine as well as attractive.Older clients are also getting procedures specifically intended to make them look younger and thinner, including facelifts, eyelid surgery, botox, and liposuction, to name a few highly demanded anti-aging procedures.

Cosmetic surgery has become such a growth industry that even a cursory Google search can direct would-be users to local clinics.Suppose the desired service is not available locally or cheaply. In that case, would-be customers can look into "medical tourism" involving other countries where they can get surgery and enjoy other travel perks, often in the form of all-expense-paid travel packages. Such medical tourism junkets have become a significant economic boost to otherwise economically disadvantaged countries, and the demand will undoubtedly rise as baby boomers grow older.

In many ways, though,this demand for cosmetic surgery is just the tip of the iceberg.While not everyone can afford (or are interested in) cosmetic surgery,the desire to look younger and healthier has sparked a vast anti-aging industry worldwide.Along with an astonishing number of books, videos, and courses available online offering advice on fighting the signs of age, more people than ever are seeking out various services offering the promise of looking younger and more desirable.That includes weight loss clinics, nutrition counselors, personal trainers, yoga instructors, and a host of other purveyors of youth and beauty.Many older adults seeking out these services seem to be driven by their fears about aging, not to mention unrealistic media representations about the human body (particularly the female body).

But other fears seem to be driving this need to look younger.Though laws banning age discrimination continue to pass in countries worldwide, many older adults feel compelled to hide visible signs of aging to avoid being thought of as "old." The need to look younger has sparked an entire movement surrounding the concept of "agelessness," particularly for women who are far more likely than men to be judged for their appearance.Not surprisingly, many celebrities, male and female alike, have lent their name to various anti-aging products of doubtful validity, all of which promise users the same "agelessness" they enjoy themselves (actress Suzanne Somers and her endorsement of bioidentical hormone replacement therapy, for example).

However, almost inevitably, we are now facing a backlash in the form of a "body positive" movement encouraging men, especially women, to reject what feminist researchers describe as the objectifying of physical appearance favoring a more "genuine" look.It also highlights the double standard that exists between older men and women. While older men can be considered competent regardless of their gray hair and wrinkles, recent research suggests that many women find themselves required to look younger to be accepted.Even those women who refrain from dying their hair to appear more authentic often use other beauty practices to look more youthful. Ironically, for women who choose to make themselves look younger, the most likely backlash they experience usually comes from other women rather than men, a finding recently supported by evolutionary psychology research.

But is there anything wrong with wanting to look younger and more desirable?Numerous studies show the link between perceived attractiveness, self-esteem, and subjective wellbeing.According to one study recently published in the Journal of Women and Aging, the same body dissatisfaction often seen in adolescent girls can also occur in many women as they grow older.An online survey of over three hundred women between the ages of forty-five and sixty-five found that women who were dissatisfied with their appearance and were afraid of growing older were especially prone to depression.They were also far more likely to resort to anti-aging regimens to make themselves look younger.

In another study published last year, researchers found a strong link between perceived self-attractiveness and life satisfaction in women from different age groups (825, 3045, and over 60).The study showed similar results for both overall perceived attractiveness and attractiveness of specific body parts.And people who look younger also feel younger, something that has enormous health benefits, particularly in helping people handle stress (including financial stress), cope with depression and loneliness, and greater sexual satisfaction.

Our recent work on psychological and subjective aging clocks developed using AI also provided a clue that looking younger and thinking more positively about the future correlated with lower mortality. So by looking younger you may actually live longer.

Despite the ongoing political battle over body positivity and "authenticity," wanting to look younger is very natural and certainly no cause for being stigmatized.Ultimately though, simply looking younger is not enough.we still need to invest more efforts into aging and longevity biotechnology.Helping people to live longer and more productive lives remains one of the most significant medical challenges imaginable.Also, eliminating the risk of deadly age-related conditions such as Alzheimer's disease makes research into aging an investment that will repay itself many times over.

Cosmetic procedures coupled with aging clocks may help improve the outlook on life, provide more ... [+] optimistic view on the future, extend reproductive age, and decrease mortality.

To learn more about the exciting and complex field of anti-aging research, consider attending the largest conference on aging research and drug discovery organized every year by the University of Copenhagen and Columbia University 8th Aging Research and Drug Discovery.

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Linda Robson says struggle with menopause turned her into a monster – Metro

Posted: July 21, 2021 at 2:44 am

Linda Robson said the menopause turned her into a madwoman (Picture: ITV)

Linda Robson spoke honestly about her experiences with the menopause admitting it made her unbearable to live with.

The actress, 63, said on Thursdays Loose Women that she ended up with a low libido and began to shout at her children.

The menopause is when a woman stops having periods and is no longer able to get pregnant naturally. Symptoms can include hot flushes, vaginal dryness, difficulty sleeping or low mood.

According to the NHS, the severity of the symptoms people going through menopause will experience will vary, and symptoms often begin months or years before the menstruation stops altogether. This is known as perimenopause.

Lindas life was transformed for the better when she was on hormone replacement therapy (HRT) to help relieve the symptoms, but stopped when her sister was battling cancer, which led to her feeling even worse.

She told panelists Charlene White, Brenda Edwards and Nadia Sawalha: I knew I was going through the menopause because my sister went through it at 38 and I started getting all the symptoms, hot sweats, and no one can understand what a hot sweat is until youve had one.

You think its like a flash but its not. It actually goes through your whole body. It goes up through your back, over your head, all your make-ups gone.

She went on: Ive always had quite a high libido and all of a sudden I had no libido and I turned into a mad woman. I was shouting at the kids all the time, at my husband and everything.

So I decided to try the HRT and it just changed my life. But then my sister got breast cancer so me and my other sister came off of HRT. Its the worst Ive ever been.

Nadia interjected: I think that was the beginning of you going downhill.

Linda agreed: I was always quite happy, breezy, and all of a sudden I was a monster. The kids were going to me, Mum youve gotta go back on HRT and as soon as I went back on it my life changed again. My libidos through the roof!

Typically menopause comes on between the ages of 45 and 55, with the average age being 51.

Nadia urged people to speak to someone if any of their discussion resonated with them.

Loose Women airs weekdays from 12.30pm on ITV.

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If youve got a celebrity story, video or pictures get in touch with the Metro.co.uk entertainment team by emailing us celebtips@metro.co.uk, calling 020 3615 2145 or by visiting our Submit Stuff page wed love to hear from you.

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Beasley Allen’s Navan Ward Installed as the American Association of Justice 75th President – Montgomery Independent

Posted: July 21, 2021 at 2:44 am

Navan plans to focus on enhancing diversity and inclusion within the AAJ.

ATLANTA (July 14, 2021) Beasley Allens Navan Ward was installed as the 75th president of the American Association for Justice today during the groups annual meeting. He is the second minority to hold the position, with the first being more than two decades ago. It is this area of representation that Ward and other AAJ leaders are working to improve on in the future and is central to Wards goals for his administration.

I am thankful for my experience at Beasley Allen, where our leadership fosters a culture of inclusion and values the unique backgrounds, experiences and personal achievements of minority lawyers, Ward said. The firm has been recognized for its focus on diversity among its lawyers, including by Law360 as one of the 10 Best Law Firms for Black Attorneys in the U.S and previously recognized as the #1 law firm with African American partners. It is an approach we want to nurture in firms nationwide, Ward said.

The AAJ leadership understands that leaders from diverse backgrounds can strengthen and empower each other and those they lead. Navan has worked with AAJ leadership to recruit, train, and encourage members from different backgrounds (including race, gender, age, geography, and level of career) to become active leaders.

On many different levels and across various landscapes, our country is rebuilding, so it is the perfect time to do the same within the American Association for Justice. The AAJ is an organization that advocates for access to justice and works to preserve the rights given by the 7th Amendment of the U.S. Constitution. It is important that the organization genuinely reflects the diversity that makes it great. I look forward to implementing strategies that will build on the work of the past presidents and strengthen our leadership moving forward, Ward said.

Ward launched what has become the cornerstone of these efforts in 2012 called the American Association for Justice Diversity and Inclusion Leadership Academy. The Leadership Academy trains highly qualified and talented AAJ members, particularly those underrepresented within the association, to help them become more effective leaders. Graduates are encouraged to participate in leadership opportunities throughout AAJ, including the six-to-seven-year national officer track. The Leadership Academy provides leadership and benefits from continued training and leadership development. It is one way the organization guarantees the retention of minority leaders who can ensure underrepresented member groups have a voice in the future of the AAJ.

Ward is the firms lead attorney on the metal-on-metal hip implant litigation and proton pump inhibitor (PPI) litigation and practices from the Atlanta office. Currently, he serves on the Plaintiffs Steering Committee (PSC) for the DePuy ASR Hip Implant Recall Multi-District Litigation (MDL), DePuy Pinnacle Hip Implant MDL and was appointed as co-lead counsel for the Plaintiffs Executive Committee (PEC) in the Biomet M2a Magnum Hip Implant Products Liability MDL. Ward has been instrumental in assisting with the verdicts and global settlements against major hip implant manufacturers, including Johnson & Johnson / DePuy for $4.057 billion, Howmedica Osteonics Corporation / Stryker for over $1 billion, and Biomet Corporation for more than $250 million, and additional confidential settlements involving other metal-on-metal or modular-neck hip components. Ward has also been appointed to the PEC for the PPI MDL.

Before his work on PPI and hip implant litigation, Ward was heavily involved with the hormone replacement therapy litigation, representing hundreds of women diagnosed with breast cancer due to ingesting these combination hormone medications. His trial team was responsible for obtaining a $72.6 million verdict for three hormone therapy clients that went to trial. Ward was also responsible for overseeing the Meridia pharmaceutical drug litigation. This medication caused heart attacks and strokes and was heavily involved with the Cox-2 (Vioxx, Celebrex and Bextra) pharmaceutical drug litigation. His practice has also handled personal injury and wrongful death cases, including those involving nursing home abuse and neglect and trucking crashes. Overall, Ward has obtained more than $360 million for the specific clients that he has represented in the various areas he has practiced.

For his efforts in representing clients, Beasley Allen awarded him as the firms Litigator of the Year in 2013 and Mass Torts Litigator of the Year in 2011 and 2014.

In 2017, Ward received the AAJ Minority Caucus Stalwart Award for his dedicated years of service to the Minority Caucus and the organization overall. It also awarded him the AAJ Distinguished Service Award in 2012 and 2015 and its Wiedemann & Wysocki Award in 2014. Ward has been regularly selected to the Best Lawyers in America list, the Super Lawyers list, and named to the LawDragon 500 Leading Plaintiff Consumer Lawyers, the 500 best attorneys across the nation in this category.

Ward previously served in other AAJ leadership positions, including a past chairman of the Minority Caucus, past chairman of the Diversity Committee, and a member of the Board of Governors. He is a former Alabama State Bar delegate for the American Bar Association, past president of the Alabama Lawyers Association, the Alabama State Bars Young Lawyers Section, and the Montgomery County Association for Justice. Ward was a member of Leadership Montgomerys Class XXI, a former chairman of the Father Walters Charity Golf Tournament, and a member of the Alabama Law Foundation Grant Committee.

About Beasley Allen Law Firm

Founded in 1979, Beasley Allen Law Firm is a leader in complex plaintiff litigation nationwide. We work with attorneys and clients nationwide and have offices located in Atlanta, Georgia, Montgomery, Alabama, and Mobile, Alabama.Our award-winning attorneys live by our creed of helping those who need it most. For more information about our firm, please visit us online at http://www.beasleyallen.com.

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Learn how to remove unwanted fat with procedures beyond liposuction – ABC 4

Posted: July 21, 2021 at 2:43 am

Dr. Bill Cimikoski, Medical Director of Utah Stem Cellsjoined Surae on The Daily Dish to discuss the BodyTite and Facetite procedures. He tells Surae that these procedures are excellent for getting rid of unwanted fat, while at the same time shrink wrapping the skin so that any loose skin is simultaneously tightened at the same time.

For some individuals, there may only be minimal (or none at all) fat to extract and it might be only necessary to tighten the skin. Depending on the area Utah Stem Cells are treating, they often see that in some individuals, there isnt really any fat to speak of and their patients are just looking for skin tightening and this is an excellent way to achieve that goal!

Unfortunately, on the other hand, some patients do have a large amount of fat in certain areas and then this device is also accompanied by liposuction. This is where they can suck the fat in addition to tightening the loose skin at the same time.This procedure is called Radio Frequency assisted Liposuction. At Utah Stem Cells they also offer High Definition Radio Frequency assisted liposuction to sculpt abs.

They offer many different treatments for different areas of the body, including the following:

All procedures are in-office and with only small holes or needle punctures, which heal completely without scarring. There is no need for general anesthesia and all are completed with lidocaine fluid although they do offer nitrous oxide, ketamine, and other methods to keep people comfortable and less anxious.

As a special gift, anyone who calls in after viewing The Daily Dish today will be entitled to $200 off any procedure.

To find out more about how Dr. Bill Cimikoski and Utah Stem Cells can help you, visit their website or you can give them a call at Phone number: (801) 999-4860

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John Theurer Cancer Center Investigators Participated in ZUMA-7 Study Showing Value of CAR T-Cell Therapy as Second-Line Treatment for Relapsed Large…

Posted: July 21, 2021 at 2:42 am

Newswise HACKENSACK, N.J. (DATE TK) A new study has found that using CAR T-cell therapy as the second line of treatment for diffusing large B-cell lymphoma (DLBCL) that has returned or continued to grow after initial treatment was more effective than the standard second-line regimen of care for improving event-free survival (EFS / defined as disease progression, needing to start a new lymphoma treatment, or death from any cause). Investigators from Hackensack Meridian/Hackensack University Medical Centers John Theurer Cancer Center (JTCC), a part of Georgetown Lombardi Comprehensive Cancer Center, participated in the multicenter international study, called ZUMA-7.

With a median follow-up of two years, the study showed that patients with DLBCL who received a one-time infusion of axicabtagene ciloleucel (Yescarta) experienced a 60% improvement in EFS compared with patients who received standard care with chemotherapy and autologous stem cell transplantation. Patients in the CAR T-cell therapy group also experienced a better overall response rate. The study is continuing with additional follow-up to assess the effect of the treatments on overall survival and other key endpoints.

Axicabtagene ciloleucel is currently approved by the U.S. Food and Drug Administration for the treatment of large B-cell lymphoma that relapses after or fails to respond to at least two prior regimens of therapy.

"This is a very exciting paradigm shift for the treatment of large B-cell lymphoma," explained hematologist-oncologist Lori Leslie, M.D., who led JTCC's participation in the ZUMA-7 study. "A 60% improvement in event-free survival is more dramatic than one would anticipate and suggests that early relapsers and some patients at high risk of relapse after initial treatment may benefit from proceeding directly to CAR T-cell therapy."

About 40% of patients with DLBCL will need a second regimen of treatment.

CAR T-cell therapy is a form of treatment which involves removing white blood cells called T cells from the patient, modifying them in the laboratory to train them to see a protein (called CD19) on lymphoma cells, and then multiplying them to much larger numbers. When given back to the patient intravenously, they expand further, ideally identifying and killing cancer cells anywhere in the body.CAR T-cell therapy is a form of immunotherapy and has been called a "living therapy" because the newly trained T cells continue to find and destroy cancer cells in the body.

As a leader in CAR T therapy, we are proud to be a part of this new development in research that will continue to reshape the landscape of relapsed/refractory aggressive lymphoma who fail standard regimens of chemoimmunotherapy, said Andre Goy, M.D., M.S., chairman and executive director of John Theurer Cancer Center.

The ZUMA-7 study began in 2017 and includes 359 patients with DLBCL at 77 medical centers around the world, 30% of whom were 65 years or older. Side effects observed in the study were consistent with or even more favorable than the safety profile previously established for axicabtagene ciloleucel. The use of CAR T-cell therapy as second-line treatment did not result in any new safety concerns. Yescarta has been instrumental in transforming outcomes for DLBCL patients in third line setting. It is likely the paradigm will continue to shift towards earlier timing in patients with early failures.

"The contributions that the John Theurer Cancer Center made toward identifying a better therapy for the research and treatment of lymphoma further establishes its position as a leading center, " said Ihor Sawczuk, MD, FACS, president, Northern Region, and chief research officer, Hackensack Meridian Health. "Hackensack Meridian Health is proud to have been involved in this pivotal study."

"We are dedicated to continuing to provide the latest research-based treatments to the members of our communities," added Mark D. Sparta, FACHE, president and chief hospital executive, Hackensack University Medical Center and executive vice president of Population Health, Hackensack MeridianHealth. "John Theurer Cancer Center was the first center in New Jersey to be certified to offer CAR T-cell therapy and was active in research assessing its use long before its first FDA approval. We are very excited to see these promising results, which show how this powerful immunotherapy may benefit more people."

ABOUT JOHN THEURER CANCER CENTER HACKENSACK UNIVERSITY MEDICAL CENTER

John Theurer Cancer Center at Hackensack University Medical Center is New Jersey's best cancer center, as recognized by U.S. News & World Report. As a premier cancer center in the State we are also the largest and most comprehensive center dedicated to diagnosis, treatment, management, research, screening, and preventive care as well as survivorship of patients with all types of cancers. The 16 specialized divisions covering the complete spectrum of cancer care have developed a close-knit team of medical, research, nursing, and support staff with specialized expertise that translates into more advanced, focused care for all patients. Each year, more people in the New Jersey/New York metropolitan area turn to John Theurer Cancer Center for cancer care than to any other facility in New Jersey. John Theurer Cancer Center is part of the Georgetown Lombardi Comprehensive Cancer Center, an NCI designated comprehensive cancer center. Housed within a 775-bed not-for-profit teaching, tertiary care, and research hospital, John Theurer Cancer Center provides state-of-the-art technological advances, compassionate care, research innovations, medical expertise, and a full range of aftercare services that distinguish John Theurer Cancer Center from other facilities. For additional information, please visit http://www.jtcancercenter.org

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ExoFlo From Direct Biologics Fulfills Urgent Medical Need in COVID-19 Treatment – PRNewswire

Posted: July 21, 2021 at 2:42 am

Medical professionals report dramatic and consistent success in treating patients gravely ill with COVID-19-associated Acute Respiratory Distress Syndrome (ARDS)

AUSTIN, Texas, July 20, 2021 /PRNewswire/ -- As intensive care units across the country fill to capacity, hospital beds are in dangerously short supply, and deaths from COVID-19 continue to spike, doctors from medical centers coast to coast are reporting on the remarkable healing properties of ExoFlo, an innovative life-saving therapy that leverages the anti-inflammatory and regenerative effects of bone-marrow derived mesenchymal stem cells, when used on their most seriously ill COVID-19 patients. The physicians note that utilizing ExoFlo, administered as a single IV infusion, is safe and efficacious and is saving lives on a consistent basis.

One of the product's earliest advocates, Dr. Vik Sengupta of New York, credits ExoFlo with saving his own life. He has since used it on many critically ill patients, eagerly shared it with colleagues, and coauthored, with his wife, Dr. Sascha Sengupta, a clinical safety trial conducted at Christ Hospital in Jersey City, N.J. as part of the therapy's FDA approval process. The safety data from this study has since set the stage for the FDA approval of ExoFlo for an Investigational New Drug (IND) application for COVID-19.

"The most common cause of death among critically ill COVID-19 patients is acute respiratory distress symptom, or ARDS, in which the lungs are badly damaged, scarred and fill with fluid," explained Dr. Sengupta. "This is essentially a result of the body reacting to a threat by overproducing cytokines and other mediators of inflammation that cause damage to the lungs and other tissues in the body in a phenomenon commonly known as the 'cytokine storm.'

"ExoFlo does two important things: it remediates the inflammation almost immediately by delivering miRNA that stop the inflammatory cascade, and it delivers growth factors that promote the regeneration of healthy lung tissue for a much speedier recovery."

ExoFlo is manufactured by Direct Biologics, a market-leading cGMP manufacturer of regenerative medical products based in Austin, Texas. ExoFlo has amazed doctors with its ability to fill an unmet but urgent medical need, saving the lives of patients experiencing COVID-19- associated Acute Respiratory Distress Syndrome. Time and again, patients were able to be discharged and returned to their families rather than deteriorating to an irreversible state.

"This product could not have come at a better time," noted Dr. Angel Lazo Jr. of New Jersey. "This product also opens the door to medical solutions forpost-pandemic concerns, when there will be an urgent need to address COVID-19 survivors suffering from Post-Acute COVID Syndrome (PACS), often referred to as long-hauler COVID, and to remediate compromised immune systems and likely lasting pulmonary scarring."

Dr. Sengupta recalls his first experience with ExoFlo: "We were all exhausted, working multiple shifts during the worst of the early days of the epidemic when the New York area was hit so hard. A friend asked me if I could help her elderly parents, both in their 80s and both very ill with COVID-19.The wife had been admitted to the hospital, and unfortunately, despite our best efforts, the hospital administration refused us permission to treat her with ExoFlo.The husband, who had been declining quickly and suffered from a fever, hypoxia, delirium, diarrhea, no sense of taste, and lack of appetite, became the first documented patient in medical history to be administered an exosome-based treatment for critical respiratory illness. He received ExoFlo at home without any adverse reactions and was out of bed and singing arias within two days.Sadly, and unbeknownst to him, his wife had died in the hospital."

This was a dramatic and eye-opening experience. "When I myself fell victim to COVID, I became seriously ill very fast," noted Dr. Sengupta. "I awoke in the middle of the night, struggling to breath and sinking into delirium, and checked my O2sat, immediately realizing I was going into respiratory failure. I called my wife.She left her shift at the hospital, rushed home, and administered ExoFlo. Within 24 hours my supplemental oxygenation requirement, fever, and respiratory symptoms significantly improved. And within five days of that single dose, I was almost fully recovered from the acute infection. I firmly believe that ExoFlo saved my life."

As word spreads within the medical community, increasing numbers of doctors have been astounded by the efficacy and safety of ExoFlo. Among those who have gone on record singing its praises are Dr. Iman Bar of Newport Beach, Calif., and Dr. Jack Mann of Flushing, N.Y.

"The COVID-19 pandemic has presented doctors with a heartbreaking learning curve," said Dr. Sengupta, who has since become Direct Biologic's chief medical officer. "For months we had no choice but to stand by while patients died despite our best efforts to save them. It's an incredible relief now to have ExoFlo in our arsenal of treatments."

ExoFlo is a biopharmaceutical grade regenerative medicine product that represents a meaningful therapy in the fight against the deadly lung inflammation caused by the COVID-19 virus. The new investigational drug uses extracellular vesicles and growth factor proteins isolated from human bone marrow mesenchymal stem cells (MSCs) to reduce inflammation and direct cellular communication capable of strengthening the body's defenses and advancing its healing processes.

ExoFlo is currently in a Phase II clinical trial that expands knowledge gleaned from a prospective, open-label study in which 17 out of 24 patients demonstrated resolution of their ARDS, exhibiting biomarker and oxygenation improvements within 48-72 hours following treatment with a single 15mL intravenous dose of ExoFlo. Since receiving FDA approval of an expanded access protocol in October 2020, ExoFlo is also being utilized by physicians around the country as part of single patient emergency or compassionate use protocol, commonly referred to as eIND.

About Direct Biologics

Direct Biologics, LLC, is headquartered in Austin, Texas, with a recently expanded R&D facility located at the University of California, and an Operations and Order Fulfillment Center located in St. Louis, Missouri. Direct Biologics is a market-leading innovator and cGMP manufacturer of regenerative medical products, including a robust line of extracellular vesicle-based biological products. The company was created to expand the science of regenerative healing by delivering cutting-edge biologic technologies. Direct Biologics' management team holds extensive collective experience in biologics research, development, and commercialization, making the company a leader in the evolving, next generation segment of the biotherapeutics industry. Direct Biologics is dedicated to pursuing additional clinical applications of its extracellular vesicle biologic products through the FDA's investigational new drug application process.

For more information visithttp://www.directbiologics.com.

CONTACT INFORMATION:Tiffany Kayar[emailprotected]

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GXGX Merger: The SPAC News That Has GXGX Stock Soaring – InvestorPlace

Posted: July 21, 2021 at 2:42 am

A new SPAC (special purpose acquisition company) play is catching the eyes of investors today. The second half of 2021 looks like it will be filled with hot initial public offerings (IPOs) and SPAC mergers like Robinhood andAurora. Now, anew play will be blending the hype of a new public offering with the pandemic-fed hype toward biotech plays. GX Acquisition (NASDAQ:GXGX) is announcing today their plans to make an attractive biotech outfit public in the newest GXGX merger news.

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GX Acquisition is the newest shell company to take a private entity to market. Today, they are making known their selection in Celularity. Celularity is a New Jersey-based biotechnology outfit that specializes in the treatment of cancer and degenerative diseases. The company takes on these persistent and devastating illnesses by harnessing the power of placenta-based stem cells. Most recently, the company launched its T-cell program, in which it is developing treatments against tumorous growths using mutated placental cells.

Today, GX is happily announcing the closure of its merger with Celularity. The transaction is already paying off well for Celularity; proceeds from the transaction total a cool $138 million. Investors can look forward to Mondays trading session, as Celularity will be taking over on the Nasdaq with the ticker symbol CELU. In the meantime, the GXGX merger is elevating the SPACs stock value.

CEO of GX Dean Kehler is speaking excitedly about Celularitys prospects after seeing a listing. He says the listing will enable Celularity to continue to leverage the companys commercial and clinical stage assets to treat diseases of high unmet need.

Analysts are clamoring ahead of the CELU listing, likeMarket Realist, which called the stem-cell play risky but attractive. Perhaps one of the most appealing aspects of Celularity is its recent partnership with Peter ThielsPalantir Technologies (NYSE:PLTR). The partnership is providing Celularity with fresh cash for furthering its resources. It also ties Celularity to one of the most attractive tech plays on the market right now.

GXGX stock is soaring ahead of the news. The stock is seeing gains of over 34% since the news broke. 15 million shares are exchanging hands today as well, high above GXGXs daily average volume of 313,000.

On the date of publication, Brenden Rearickdid not have (either directly or indirectly) any positions in the securities mentioned in this article.The opinions expressed in this article are those of the writer, subject to the InvestorPlace.comPublishing Guidelines.

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