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Veritas Intercontinental: Genetics makes it possible to identify cardiovascular genetic risk and prevent cardiac accidents such as those that have…

Posted: June 23, 2021 at 2:16 am

MADRID, June 22, 2021 /PRNewswire/ -- We have recently witnessed, once again, a professional athlete suffering a cardiovascular attack during a match. This type of incidence and the possible fatal consequences result from an individual's genetic makeup. Genetic science now makes it possible to know whether a person has an elevated risk to suffer this type of cardiovascular accident and to avoid one of the main causes of death in the world, with more than 17 million deaths each year.

The role of genetics as a diagnostic element has been fundamental for several years, as Dr. Izquierdo, Chief Medical Officer of Veritas Intercontinental, says: "Sudden cardiac death (SCD) is mainly due to coronary pathologies, especially in patients over 40 years old, but in younger patients, such as many high-performance professional athletes, the contribution of genetic factors to the pathogenesis of SCD is a key factor, since we usually find a clear pattern of family inheritance at its origin, such as cardiomyopathies or channelopathies".

To help in the detection and prevention of Cardio Vascular Disease (CVD), Veritas Intercontinental offers the myCardiogenetic service, an innovative Exome sequencing and interpretation service, focused on genes related to hereditary heart diseases.

The analysis includes all genes recommended by the American Heart Association (AHA) analyzing 100 genes based on their relationship with different hereditary heart diseases. The service includes genetic counseling for the prescribing specialist, which is essential for the correct interpretation of the results and clinical management of the patient.

"myCardio,"explains Dr. Luis Izquierdo, "makes it possible to tackle the main types of cardiac disorders of hereditary origin and offers enormously valuable information to avoid the disease or to treat it much more efficiently. Until now, genetic tests related to hereditary heart disease have been very focused on certain pathologies, when it has been shown that there are many interactions between different heart conditions. myCardio allows a comprehensive approach to heart disease, with a new perspective that has been shown to be much more effective".

Advantages

Whole exome sequencing (WES) is the most appropriate tool to address the genetic heterogeneity present in inherited cardiovascular disease. Recent studies show a very significant improvement in diagnostic performance using exome sequencing compared to panels, since a high number of cases in which several mutations are recorded simultaneously are observed. The advantages of the exome are more prominent in those cases in which there is no high clinical suspicion, as well as those in which the patient has been recovered after an episode of sudden death.

The service covers the study of hereditary predisposition to Primary Cardiomyopathies, Metabolic Cardiomyopathies, Channelopathies and Arrhythmias, Syndromes with Vascular Affection, Rasopathies,other syndromes linked to cardiac pathology and other risk factors (Ischemic Heart Disease) such as Familial Hypercholesterolemia.

About Veritas Intercontinental

Veritas Intercontinental was founded in 2018 by Dr. Luis Izquierdo, Dr. Vincenzo Cirigliano and Javier de Echevarra, who have accumulated extensive experience in the field of genetics, diagnostics, and biotechnology, initially linked to Veritas Genetics, a company founded in 2014 by Prof. George Church, one of the pioneers in preventive medicine. Veritas was born with the aim of making genome sequencing and its clinical interpretation available to all citizens as a tool to prevent diseases and improve health and quality of life.

Since its inception, Veritas Intercontinental has led the activity and development of the Veritas market in Europe, Latin America, the Middle East, and Japan; with the aim of making genomics an everyday tool used for proactive healthcare management.

Based on its leadership in the application of preventive genomic medicine (myGenome), Veritas Intercontinental has expanded its offer to other areas such as perinatal medicine (myPrenatal -NIPT- and myNewborn -neonatal screening-), oncology (myCancerRisk), or the mentioned cardiovascular pathologies (myCardio), thus becoming the benchmark in advanced genomics services.

For further informationhttps://www.veritasint.com

Marta Pereiro[emailprotected]+34 915 623 675

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Xlife Sciences AG: Collaboration with the University of Marburg – BioSpace

Posted: June 23, 2021 at 2:16 am

Inventum Genetics GmbH and Universitt Marburg agree on a collaboration

The project company of Xlife Sciences AG Inventum Genetics GmbH has signed a collaboration agreement with the Philipps-University of Marburg. In this way, Inventum Genetics has the exclusive opportunity to develop new therapeutic targets using high-quality genetic data.

ZUERICH, SWITZERLAND / ACCESSWIRE / June 22, 2021 / The cooperation between Inventum Genetics and the University of Marburg is a long-term agreement. In a first projects, new therapeutic targets and biomarkers for oncological, neurodegenerative and age-related diseases are be identified using the latest genetic and molecular biological processes. Oliver R. Baumann, CEO der Xlife Sciences, is delighted with the additional prospects for drug development: "All common diseases, like the majority of all oncological, neurodegenerative and age-associated diseases, are multifactorial in cause, not just caused by a singular genetic defect. Rather, multifactorial diseases are characterized by the fact that they are based on (exogenous) environmental factors and (endogenous) genetic risk factors. In this particular project with the University of Marburg, cellular disease mechanisms of multifactorial diseases are to be elucidated. For this purpose, cells are stimulated with exogenous risk factors. It will then be examined how the cells react to it depending on their genetic makeup."

The agreement with the Philipps-University of Marburg gives the university the right to pursue the results achieved in its own research and to industrialize them, provided Inventum Genetics does not use the results itself. In this case, Inventum Genetics would benefit from the royalties generated by the university.

About the Philipps-University Marburg The Institute for Human Genetics at the Faculty of Medicine at the Philipps-University of Marburg, under the leadership of Professor Dr. Johannes Schumacher is well recognized by high-ranking publications in research in the field of human genetics. The institute operates a molecular laboratory with high quality equipment and is therefore able to deal with complex issues in the context of molecular genetic research.

About Inventum Genetics GmbH Inventum Genetics GmbH is a subsidiary of Xlife Sciences AG, which is active in research, development, manufacturing and the sale of medical and biotechnological products, especially in the field of genetics. For more information, please visit: https://www.inventumgenetics.com

About Xlife Sciences AG Xlife Sciences AG is a Swiss company with focus on investing in promising technologies in the life science industry. Xlife Sciences AG is building the bridge from research and development to healthcare markets by supporting researchers and entrepreneurs in positioning, structuring, developing and implementing their concepts. Together with industrial partners or universities, Xlife Sciences AG leads projects through the proof-of-concept phase after an invention disclosure or start-up. Subsequently, the firm focuses on out-licensing or selling the company, often with a combination of a strategic partnership. Xlife Sciences AG offers its investors direct access to the further development of innovative and future-oriented technologies at a very early stage. For more information, please visit: http://www.xlifesciences.ch

For media inquiries:Dennis Lennartz, Head Investor Relations, Xlife Sciences AG, Tel. +41 44 385 84 60, dennis.lennartz@xlifesciences.ch

For scientific inquiries:Dr. Frank Plger, Chief Scientific Officer, Xlife Sciences AG, Tel. +41 44 385 84 62,frank.ploeger@xlifesciences.ch

SOURCE: Xlife Sciences AG

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deCODE genetics: Predicting the probability of death – BioSpace

Posted: June 23, 2021 at 2:16 am

REYKJAVIK, Iceland, June 18, 2021 /PRNewswire/ -- Scientists from deCODE genetics have developed a predictor based on protein measurements in blood samples that predicts the time to all-cause death better than traditional risk factors.

In a paper published today in Communications Biology, scientists from deCODE genetics, a subsidiary of Amgen, describe how they developed predictor of how much is left of the life of a person.

Using a dataset of ~5000 protein measurements in 22,913 Icelanders, of whom 7,061 died during the study period, the scientists developed a predictor of the time to death that can outperform predictors based on multiple known risk factors. The predictor can identify the 5% at highest risk in a group of 60-80 year olds, where 88% died within ten years and the 5% at lowest risk where only 1% died within ten years.

The scientists explored how individual proteins associate with mortality and various causes of death and found most causes of death to have similar protein profiles. In particular, they found growth/differentiation factor 15 (GDF15), which has been associated with mortality and ageing before, to be an important predictor of all-cause mortality. Furthermore, they found that, on average, participants predicted at high risk of death within a short period of time had less grip strength and performed worse on an exercise tolerance test and a test of cognitive function than those predicted at lower risk.

"The predictor gives a good estimate of general health from a single blood draw," says Thjodbjorg Eiriksdottir scientist at deCODE genetics and author on the paper.

"This is pretty cool but also scary and hopefully somewhat useful", says Kari Stefansson a senior author on the paper . "This shows that our general health is reflected in the plasma proteome. Using just one blood sample per person you can easily compare large groups in a standardized way, for example, to estimate treatment effects in clinical trials."

Based in Reykjavik, Iceland, deCODE is a global leader in analyzing and understanding the human genome. Using its unique expertise in human genetics combined with growing expertise in transcriptomics and population proteomics and vast amount of phenotypic data, deCODE has discovered risk factors for dozens of common diseases and provided key insights into their pathogenesis. The purpose of understanding the genetics of disease is to use that information to create new means of diagnosing, treating and preventing disease. deCODE is a wholly-owned subsidiary of Amgen (NASDAQ: AMGN).

Contact:

Thora Kristin AsgeirsdottirPR and CommunicationsdeCODE geneticsthoraa@decode.is354 894 1909

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Genetics diagnostics in India is on the verge of transformation: Neeraj Gupta, Founder and CEO of Genes2me – The Financial Express

Posted: June 23, 2021 at 2:16 am

'If genetic testing is done at the appropriate stage, some diseases can be prevented, cured or managed better.'

The Indian diagnostics industry has been rapidly evolving over the years and its emerged to be a key component of the healthcare segment. The arrival of Covid-19 pandemic pushed the healthcare industry to the sting worldwide by throwing many challenges, and therefore the diagnostic sector too witnessed a large transition during this phase. Whether its about keeping pace with the concept of telemedicine or addressing the change within the consumer psyche, the diagnostic sector has been facing different challenges with the increase of covid cases. As COVID-19 has spread, Indias diagnostic sector has been battling the virus at the forefront. In conversation with Financial Express Neeraj Gupta, Founder and CEO of Genes2me shared his experience and threw light on the challenges, learnings, and therefore the road ahead for the diagnostic businesses in India. Excerpts:

How has the diagnostic sector evolved since the arrival of Covid-19? Being an industry leader, what were some initial challenges you faced?Previously, the molecular diagnostic sector was not harnessed. We have seen that pandemic pushed the healthcare industry to the edge, but Indias diagnostic sector rose to meet the challenges. As COVID-19 has spread, Indias diagnostic sector has been combating the virus at the forefront. Initially, the Indian health care system was not fully prepared for such a massive crisis like COVID-19. We faced challenges regarding imports for raw materials and logistics due to global supply chain disruptions. This is also one of the reasons why we decided to use our expertise in molecular diagnostics and expand the portfolio into IVD manufacturing.

How has Genes2me come to the forefront during the pandemic? Tell us about your journey of delivering 40 Million covid test kits in India to date.

We take pride in the fact that Genes2Me has been working at the front line from the very first day of the pandemic. We developed several IVD kits, including Real-Time PCR Kits, VTM Kit, RNA Extraction Kits, NGS Kits and multiplexed genotyping assays for COVID-19 detection in a quick turnaround time.

Our ViralDtect-II Real-Time PCR Kit for COVID-19 has been a real turning point. It was the first Made in India Real-Time PCR Kit with comprehensive coverage of three genes that are specific to SARS-COV-2.

Also, there have been reports of new strains of SARS-COV-2 being detected. Genes2Me has developed a Unique Mutation Classifier assay that can rapidly differentiate 40 variants between 16 SARS-CoV-2 strains. This can help in the quick genetic screening of large sections of the population.

Genes2Me have been working tirelessly and have delivered more than 40 million COVID-19 testing kits to date. Also, to meet the sudden demand surge of the second Covid wave, we ramped our manufacturing facility from 9million per month to 6 million per week. In fact, during this time, Genes2Me contributed over 20% of the entire Indian testing needs for RT-PCR.

From where the idea of stepping into manufacturing IVD kits came under the Make in India initiative? What have been the challenges and opportunities?

When the pandemic hit us, not many diagnostic labs had the necessary infrastructure or accreditations to offer Covid testing facilities. As the pandemic gathered force, there was not only demand for faster testing but also testing in much higher volumes. The response to that struggle was the idea behind IVD kits under the Make in India initiative.The Indian government has taken progressive steps to boost the capacities of the domestic IVD sector. Genes2Me is also working to collaborate with the government and prestigious medical institutes to offer services on the innovative classifier panel of SARS-COV-2. In this manner, we can all be better prepared to face the challenges posed by this virus frequently changing genetic makeup.

What changes should diagnostic companies bring to fight the pandemic and meet the current market demand?

Post Covid-19, we have seen the entry of many companies into the Molecular Diagnostics Testing and Kit Manufacturing segment. Unfortunately, not many companies have been able to deliver quality genetic solutions in a fast turnaround time. This is evident from the fact that around 10-15 players used to compete in the Tender queries of IVD products till last year. But now, only 4-5 bidders are participating in the Tender queries as most of the companies have failed to satisfy customer expectations of Quality Product.

If you want to build a sustainable diagnostic company, you should maintain Quality Manufacturing and Testing Standards. Genes2Me has responded by building capacities and training faster to keep up with the surge without compromising the sensitivity of Genetic Solutions.

What have been some recent developments and future plans of Genes2me?

Genes2Me is vigorously working to leverage the large installed base of molecular testing platforms across the globe. With the help of our expertise and access to advanced technologies, we have developed several assays for Infectious diseases, Oncology and Reproductive Health in India. In the past, most of these test panels were import-dependent from other countries.

In addition, under the Make in India initiative, we are working to develop diverse nucleic acid research and diagnostics solutions along with NGS reagents for genome sequencing. Again, these solutions were dependent on import from different nations.

Genes2Me has also ramped up Covid-19 testing facilities by installing more infrastructure, hiring manpower and training them meticulously to ensure smooth functioning. Our advanced high throughput Real-Time PCR testing Lab at Gurgaon, Haryana, has an unmatched capacity to perform 8K-10K tests per day.

How do you see the future of Genetic Diagnostics in India?

India has a population of more than 1.26 billion people, with 26 million births occurring every year. This means that the burden of a genetic disease is very high. With the help of genetic diagnostics, many diseases can be predicted with great accuracy. If genetic testing is done at the appropriate stage, some diseases can be prevented, cured or managed better.

Genetics diagnostics in India is on the verge of transformation. There has been widespread awareness and recognition of the increasing incidence of congenital and hereditary genetic diseases in urban India. More and more people are seeking genetic testing and counselling services. Genetic diagnostic in India will evolve from a niche speciality to a wide scope of applications for complex diseases and personal use.

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Genetics diagnostics in India is on the verge of transformation: Neeraj Gupta, Founder and CEO of Genes2me - The Financial Express

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Linwood Barclay emerges from the pandemic to talk about the latest genetic mystery hes penned – The Globe and Mail

Posted: June 23, 2021 at 2:16 am

Toronto, Ontario - Thursday August, 9 -- Linwood Barclay -- Author Linwood Barclay poses for a picture in Toronto, Thursday August 9, 2018. (Mark Blinch/Globe and Mail)

Mark Blinch/The Globe and Mail

Linwood Barclay had a decades-long career as a newspaper editor and humour columnist before he transitioned to writing thrillers in the early aughts. To call that move a success would be an understatement. Barclays 20 novels, which includes the Promise Falls trilogy along with a memoir about running his familys trailer park north of Peterborough in his youth, and two novels for children have sold millions and been translated into more than 25 languages. Stephen King counts himself a fan.

His latest, Find You First, features cars, genetic testing and not one but two unrelated yet intertwined multimillionaires at opposite ends of the empathy spectrum. One, Jeremy Pritkin, is an uber-creepy Jeffrey Epstein-type philanthropist who regularly invites young girls to his massive Manhattan digs. The other, Miles Cookson, has just been diagnosed with a terminal disease that has a 50-per-cent rate of genetic transmission and is racing to track down the nine adults he fathered decades ago through a sperm bank his plan being to warn them, and to make them his direct heirs. But the plan quickly hits a snag: His unwitting offspring are getting serially knocked off before hes even able to reach them.

The Jeffrey Epstein affair was clearly it sounds wrong to say inspiration, so lets go with spark for this book. How did you think to intertwine it with genetics?

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What sparked the novel was a New York Times piece where someone took photos of all these half siblings who were the product of the same sperm donation, and I thought, thats a heartwarming personal-interest story. But as a thriller writer you think: How could that go horribly wrong? So I was working on that storyline, and when I was starting to plot the book out, the most obvious answer to the mystery was that one of the potential heirs was wiping out the others. And that seemed so obvious that I thought I needed another parallel story that would address the mystery, which is when I started thinking about the Epstein thing.

Have you had your DNA tested?

No. And I dont think I could have written this thriller 15 years ago because you didnt have ads on TV every night saying, Hey, send us a saliva sample! Itll tell you everything about you, and who you could be related to. I looked at this trend more as an opportunity for a story than something I was really curious about doing myself. But my brother had his done, and it didnt reveal anything particularly startling.

Tech is an unavoidable element in modern-day thrillers, just as it is in our lives. Is it something you embrace or just accommodate in your books?

Accommodate. I did an earlier book, Trust Your Eyes, thats a little more involved with tech. It was rooted around Google Street View. There are elements of tech that are very worrisome. If theres any kind of trend that concerns me its been the death, or the decline, of newspapers. Also this kind of embracing of ignorance, and real fake news. The stuff people will believe is so blatantly, obviously not true. Those issues scare me even more than the tech stuff, although the tech stuff plays a role in it because its whats spreading all this disinformation.

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From the vantage point of the 20-novel milestone, what do you feel youre better at? Whats still hard?

Its a little less daunting every time I start, but Ill write a book and make a mistake, or see something I should have done differently, and I think, Okay Ill learn from that for the next book. And I dont make that mistake, but I make a new one, so I find that Im always learning. The trick is to give readers what theyre hoping to get but not give them the same thing you gave them last time. And I dont kill myself doing it the way I used to. I used to try to write 3,000 words a day, and now I do 1,800 to 2,100.

Have you stayed in touch with your readers during this pandemic year?

I have a couple Facebook pages, and Twitter, so I get a lot of feedback, which is nice. Especially in a year when you couldnt go out and see anybody. I always do a U.K. tour and hit Ireland and Scotland, so there was none of that. Writing is a pretty isolating occupation to begin with, so tours and festivals are your one chance to get out and discover that the world is populated.

What parts of the writing process do you like or dislike the most?

I still think finishing is the most fun. There are two parts I really hate. When you send your first draft to your editors its like waiting for tests to come back from the doctor. Is it good news or bad news? And then theres the final reading of page proofs. By that point Im so sick of it. I cant see any mistakes because Im reading what I expect to read, so I never enjoy that.

This book and many of your others have riffed on current events. Do you see any possibilities in a pandemic-lockdown theme?

Ive set next years book in 2022 with the hope that well have moved past this. All Ive done is reference it. My character finds an old mask between his car seats, or some rubber gloves or sanitizer in the glove box. Its such a global event that I think itll end up being incorporated in just about anything that we do, but to actually write a pandemic novel? Theres a guy named Stephen King who wrote a fairly good one back around 1978 or 79, so its kind of been done. The thing is, will we want to read a pandemic novel when were done with this? Ill be happy to forget about it.

Speaking of Stephen King, hes blurbed this book as your best. Do you agree?

It would be rude to argue! Maybe it is. I think its got more momentum than maybe anything else Ive done. It really flies. Trust Your Eyes might still be my favourite, but you know, [King] may be right: This might be it. Maybe I should just quit. But every book you do you hope itll be the best and there are some years where you think, Yeah I pulled it off and others where you think, I can get away with this. Thats the challenge for those of us who write this kind of fiction: Theres an expectation of a book a year.

So whats next? You mentioned a couple of books coming out

Ive done the second draft of next years book, and I wrote a screenplay adaptation for my book Fear the Worst that Jason Priestley wants to star in and produce, and we think we have a director now. But mostly I think I can coast through the summer and then Ill have to get back seriously to writing whatever the next book will be in the fall.

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This interview has been edited and condensed.

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Linwood Barclay emerges from the pandemic to talk about the latest genetic mystery hes penned - The Globe and Mail

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Asymmetrex Will Present a New Test for Therapeutic Stem Cell Potency at the ISSCR 2021 Annual Meeting – PRNewswire

Posted: June 23, 2021 at 2:15 am

Potency tests assure doctors that a medicine has good quality and will be effective for treatment. Although potency tests are common for drug medicines, developing them for stem cell treatments has been difficult. For stem cell treatments, no reliable potency tests have been available.

At the June 21-26, 2021 Annual Meeting of the International Society for Stem Cell Research, stem cell biotechnology company Asymmetrex will present data and examples for a new test for evaluation of the potency of tissue stem cell treatments. The technology, called kinetic stem cell (KSC) counting, can tell doctors the number of live tissue-renewing stem cells in a treatment sample.

The President & CEO of Asymmetrex, James L. Sherley, M.D., Ph.D., explains, "Stem cell medicine has needed a quality and effectiveness index like drug specific activity for pharmaceuticals. What could work better than knowing the number of live tissue stem cells that can restore other tissue cells? That's what our KSC counting TORTOISE TestTM platform can tell doctors: the number of live stem cells in a treatment that can renew an organ or tissue."

Asymmetrex is currently focused on conducting preclinical and clinical evaluations of how well its tissue stem cell-specific data indicate the effectiveness of stem cell treatments in different patients. In his company's presentations at ISSCR 2021, Sherley says that he will also introduce the immediate benefits of KSC counting to stem cell scientists for their tissue stem cell research. "It's a no brainer that now knowing how many tissue stem cells are in experiments will greatly improve stem cell researchand, as a consequence, stem cell medicine."

About Asymmetrex

Asymmetrex, LLC is a Massachusetts life sciences company with a focus on developing technologies to advance stem cell medicine. Asymmetrex is a member company of the Advanced Regenerative Manufacturing Institute BioFabUSA (ARMI)and the Massachusetts Biotechnology Council (MassBio).

Media Contact: James L Sherley, [emailprotected]

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Infertility: Men account for at least half of cases. So why have women shouldered the blame? – The Irish Times

Posted: June 23, 2021 at 2:15 am

Male scientists have long waxed poetic on the contents of their testes. Sperm is a drop of brain, wrote the ancient Greek writer Diogenes Laertius. Leonardo da Vinci drew the penis with a sperm duct that connected directly to the spinal cord. The 17th-century microscopist Antonie van Leeuwenhoek claimed that each sperm cell contained within it a folded-up human being waiting patiently to unfurl.

For nearly as long, scientists have fretted about sperms seemingly inevitable decline. Most recently, a series of alarming headlines as well as a new book by a public health researcher at Mount Sinai Medical Center in New York warned that falling sperm counts might threaten the future of the human race. Its a global existential crisis, saysShanna H Swan, author of the book Count Down.

Most of these headlines can be traced to an influential 2017 meta-analysis by Swan and others, which found that sperm counts in Europe, North America, Australia and New Zealand had plummeted by nearly 60 per cent since 1973. The authors screened 7,500 sperm-count studies from around the world, weeded out most of them and ultimately analysed 185 studies on 43,000 men worldwide.

They called the decline a canary in the coal mine for waning male reproductive health worldwide. Today, the authors would revise that statement. There is clear and present alarm now, says Dr Hagai Levine, a public-health researcher at Hebrew University-Hadassah School of Public Health and an author of the 2017 review. The canary is in trouble now. Swan agrees.

Now a group of interdisciplinary researchers from Harvard and Massachusetts Institute of Technology contend that fears of an impending Spermageddon have been vastly overstated. In a study published in May in the journal Human Fertility, they re-evaluated the 2017 review and found that it relied on flawed assumptions and failed to consider alternate explanations for the apparent decline of sperm.

Sarah Richardson, a Harvard scholar on gender and science and the senior author ofthe new study, calls the conclusion of the 2017 review an astonishing and terrifying claim that, were it to be true, would justify the apocalyptic tenor of some of the writing. Fortunately, she and her coauthors argue, there is little evidence that this is the case.

The 2017 authors were methodologically rigorous in screening sperm-count studies for quality and consistency, Richardson and her colleagues write. But even the data that passed muster was geographically sparse and uneven and often lacked basic criteria such as the age of the men. Moreover, its authors took for granted that a single metric sperm count was an accurate predictor of male fertility and overall health.

No one knows what an optimal sperm count is. The World Health Organisation sets a range of normal sperm count as from 15 million to 250 million sperm per millilitre. (Men produce about 2ml to 5ml per ejaculation.) But it isnt clear that more is better. Above a certain threshold 40 million per millilitre, according to the WHO a higher count does not mean a man is more fertile.

Doubling your sperm count from 25 million to 50 million doesnt double your chances, says Allan Pacey, an andrologist at the University of Sheffield, in England, and the editor of Human Fertility. Doubling it from 100 million to 200 million doesnt double your chances in fact it flattens off, if anything.

Germaine M Buck Louis, a reproductive-public-health researcher at George Mason University, in the United States, agrees that sperm count is a poor indicator of fertility. We dont see it predicting much of anything, especially in the context of a partner with a healthy female pelvis, says Buck Louis, who was not involved in the sperm-count studies.

The authors of the 2017 study inferred that lower sperm counts equated to lower fertility even though the sperm-count declines they documented all took place within the normal range, Richardson notes. Its similar to the whole conversation around testosterone more is better, and more is manlier, she says. Thats really a point we make, that there is no known normal or baseline for average population sperm counts.

Sperm count has other limitations as a metric. It takes about two months for stem cells in the testes to develop into new sperm, meaning that any single count is merely a snapshot of an evolving landscape.

Something thats going on in a mans body one month may be totally different from whats happening the next month, and the effects on sperm count might be changing also, says Meredith Reiches, an author ofthe 2021 paper and a biological anthropologist at the University of Massachusetts,Boston.

It also overlooks a vital piece of the infertility puzzle: women. Focusing only on the male metric leaves out key interactions between sperm, the female reproductive tract and the egg. Its very important, actually, to look at the couple, says Dr Bradley D Anawalt, a reproductive endocrinologist at the University of Washington school of medicine.

In her book, Swan suggests that sperm counts have plummeted largely because of the rise of endocrine disrupters, a class of hormone-mimicking chemicals found in everything from shampoo to TV-dinner packaging. (She also cites lifestyle factors such as obesity, alcoholand smoking.)

Richardson and her coauthors suggested an alternative: perhaps sperm levels naturally rise and fall over time and within populations. The question has not been explored by reproductive researchers and cannot be answered easily, as global sperm counts before 1970 are largely unknown.

There are other possible explanations, as well. Sperm-counting is a tricky business and notoriously prone to human error, Pacey says. (I say it from the point of view of someone who spent 30 years counting sperm and knows how difficult it is, he adds.) In a 2013 review article, he notes that as methodologies for counting had improved and been standardised since the 1980s, sperm counts had appeared to fall. In other words, it may simply be that earlier scientists were overcounting sperm.

Swan and Levine agree that exploring these alternative hypotheses was important, so that threats to reproductive health could be prevented. We showed evidence for decline, and raised alarm, Levine writes in an email. We need to study the causes, including the unlikely possibility of non-pathological decline.

There is one point that every author agrees on: mens reproductive health matters. And until nowit has been surprisingly neglected.

Male infertility contributes to at least half of all cases of infertility worldwide. Yet, historically, women have shouldered most of the blame for the inability to conceive. And with the rise of reproductive technologies such as in-vitro fertilisation, womens bodies are the ones that have been meticulously measured and tracked by reproductive medicine.

As a result, science still lacks basic knowledge when it comes to sperm, says Rene Almeling, a sociologist of medicine and author of GUYnecology: The Missing Science of Mens Reproductive Health.

We have built up such a medical infrastructure around the fertility and reproductivity of womens bodies that we havent asked some of the basic questions about mens reproductive health, Almeling says. There is just so, so much basic research still to be done about sperm.

The main qualities of sperm that infertility specialists look at nowadays how many, what shape and how they swim have not changed in the past 40 years, says Dr Abraham Morgentaler, a urologist and founder of Mens Health Boston.

Morgentaler, who worked at a semen-analysis lab at Beth Israel Deaconess Medical Center, in Boston, in the 1980s, attributes this stagnation to the rise of IVF and other technologies, which have become frontline treatments for almost any male-factor fertility problem. It almost doesnt even matter whats wrong with the sperm, he says.

These knowledge gaps radiate out to all bodies. Swan says part of her motivation for writing the book was that she wanted to see men and women become more proactive about their reproductive health.

Its invisible, she says. People dont talk about it. You talk about, Oh, Ive got a high cholesterol measure, or My blood pressures up. But you never would say, My egg count is down, or My sperm count is down.

Richardson agrees that the effect of reproductive toxins on fertility deserved further investigation. To say that we think these are alarmist and apocalyptic claims, and theyre not well founded, is not to say that we think it isnt an important research agenda, she says. There is a need to centre on mens reproductive health and understand their bodies as reproductive and as porous to the environment as anyones bodies. New York Times

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Infertility: Men account for at least half of cases. So why have women shouldered the blame? - The Irish Times

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‘Nanodecoy’ Therapy Binds and Neutralizes SARS-CoV-2 Virus – NC State News

Posted: June 23, 2021 at 2:11 am

Nanodecoys made from human lung spheroid cells (LSCs) can bind to and neutralize SARS-CoV-2, promoting viral clearance and reducing lung injury in a macaque model of COVID-19. By mimicking the receptor that the virus binds to rather than targeting the virus itself, nanodecoy therapy could remain effective against emerging variants of the virus.

Download video transcript (.RTF)

SARS-CoV-2 enters a cell when its spike protein binds to the angiotensin-converting enzyme 2 (ACE2) receptor on the cells surface. LSCs a natural mixture of lung epithelial stem cells and mesenchymal cells also express ACE2, making them a perfect vehicle for tricking the virus.

If you think of the spike protein as a key and the cells ACE2 receptor as a lock, then what we are doing with the nanodecoys is overwhelming the virus with fake locks so that it cannot find the ones that let it enter lung cells, says Ke Cheng, corresponding author of the research. The fake locks bind and trap the virus, preventing it from infecting cells and replicating, and the bodys immune system takes care of the rest.

Cheng is the Randall B. Terry Jr. Distinguished Professor in Regenerative Medicine at North Carolina State University and a professor in the NCState/UNC-Chapel Hill Joint Department of Biomedical Engineering.

Cheng and colleagues from NCState and UNC-CH converted individual LSCs into nanovesicles, or tiny cell membrane bubbles with ACE2 receptors and other lung cell-specific proteins on the surface.

They confirmed that the spike protein did bind to the ACE2 receptors on the decoys in vitro, then used a fabricated SARS-Co-V-2 mimic virus for in vivo testing in a mouse model. The decoys were delivered via inhalation therapy. In mice, the nanodecoys remained in the lungs for 72 hours after one dose and accelerated clearance of the mimic virus.

Finally, a contract research organization conducted a pilot study in a macaque model and found that inhalation therapy with the nanodecoys accelerated viral clearance, and reduced inflammation and fibrosis in the lungs. Although no toxicity was noted in either the mouse or macaque study, further study will be necessary to translate this therapy for human testing and determine exactly how the nanodecoys are cleared by the body.

These nanodecoys are essentially cell ghosts, and one LSC can generate around 11,000 of them, Cheng says. Deploying millions of these decoys exponentially increases the surface area of fake binding sites for trapping the virus, and their small size basically turns them into little bite-sized snacks for macrophages, so they are cleared very efficiently.

The researchers point out three other benefits of the LSC nanodecoys. First, they can be delivered non-invasively to the lungs via inhalation therapy. Second, since the nanodecoys are acellular theres nothing living inside they can be easily preserved and remain stable longer, enabling off-the-shelf use. Finally, LSCs are already in use in other clinical trials, so there is an increased likelihood of being able to use them in the near future.

By focusing on the bodys defenses rather than a virus that will keep mutating we have the potential to create a therapy that will be useful long-term, Cheng says. As long as the virus needs to enter the lung cell, we can keep tricking it.

The research appears in Nature Nanotechnology and was supported by the National Institutes of Health and the American Heart Association. Dr. Jason Lobo, pulmonologist at UNC-CH, is co-author of the paper.

-peake-

Note to editors: An abstract follows.

Cell-Mimicking Nanodecoys Neutralize SARS-CoV-2 and Mitigate Lung Injury in a Nonhuman Primate Model of COVID-19

DOI: 10.1038/s41565-021-00923-2

Authors: Zhenhua Li, Zhenzhen Wang, Phuong-Uyen C. Dinh, Dashuai Zhu, Kristen D. Popowski, Halle Lutz, Shiqi Hu, Ke Cheng, North Carolina State University; Leonard J. Lobo, University of North Carolina at Chapel Hill; Mark G. Lewis, Anthony Cook, Hanne Andersen, Jack Greenhouse, Laurent Pessaint, Bioqual, Inc.

Published: Online June 17, 2021 in Nature Nanotechnology

Abstract:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has grown into a global pandemic, and no specific antiviral treatments have been approved to date. The angiotensin-converting enzyme 2 (ACE2) plays a fundamental role in SARS-CoV-2 pathogenesis as it allows viral entry into host cells. Here we show that ACE2 nanodecoys derived from human lung spheroid cells (LSCs) can bind and neutralize SARS-CoV-2 and protect the host lung cells from infection. In mice, the nanodecoys were delivered via inhalation therapy and resided in the lungs for over 72 hours post-delivery. Furthermore, inhalation of nanodecoys accelerated clearance of SARS-CoV-2 mimics from the lungs, with no observed toxicity. In cynomolgus macaques challenged with live SARS-CoV-2, four doses of nanodecoys delivered by inhalation promoted viral clearance and reduced lung injury. Our results suggest that LSC-nanodecoys can serve as a potential therapeutic agent for treating COVID-19.

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Nanodecoy Therapy is an Effective Alternative to Neutralize SARS-CoV-2 Virus – AZoNano

Posted: June 23, 2021 at 2:11 am

Written by AZoNanoJun 18 2021

Nanodecoys are made from human lung spheroid cells (LSCs). They bind and neutralize the SARS-CoV-2 virus, promoting viral clearance and reducing injury to the lungs in a COVID-19 macaque model.

Nanodecoy therapy mimics the receptor where the virus binds and thus targets the virus itself. This therapy could be effective against the emerging virus variants.

SARS-CoV-2 penetrates a cell when its spike protein is binding to the angiotensin-converting enzyme 2 (ACE2) receptor found on the surface of the cell. LSCs a natural combination of lung epithelial stem cells and mesenchymal cells also express ACE2. This makes them a perfect vehicle to trick the virus.

If you think of the spike protein as a key and the cells ACE2 receptor as a lock, then what we are doing with the nanodecoys is overwhelming the virus with fake locks so that it cannot find the ones that let it enter lung cells. The fake locks bind and trap the virus, preventing it from infecting cells and replicating, and the bodys immune system takes care of the rest.

Ke Cheng, Randall B. Terry Jr. Distinguished Professor in Regenerative Medicine, North Carolina State University

Cheng is also a professor in the Joint Department of Biomedical Engineering, North Carolina State University (NC State)/UNC-Chapel Hill, and the corresponding author of the study.

Cheng and work colleagues from the NC State and UNC-CH transformed LSCs into nanovesicles or tiny cell membrane bubbles with ACE2 receptors as well as other lung cell-specific proteins on the surface.

The researchers confirmed that the spike protein indeed adheres to the ACE2 receptors on the decoys in vitro. They subsequently used a fabricated SARS-Co-V-2 mimicking virus for in vivo testing in a mouse model and delivered the decoys with the help of inhalation therapy. However, the nanodecoys remained in the lungs of the mice for 72 hours after one dose and helped in quickly clearing the mimicking virus.

Later, a contract research organization performed a pilot study in a macaque model and observed that inhalation therapy employing nanodecoys not only accelerated the viral clearance but also reduced fibrosis and inflammation in the lungs. No toxicity was noted in both the mouse and macaque study, but more research is needed to translate this treatment for human testing and precisely find out how the nanodecoys are cleared by the body.

These nanodecoys are essentially cell ghosts, and one LSC can generate around 11,000 of them. Deploying millions of these decoys exponentially increases the surface area of fake binding sites for trapping the virus, and their small size basically turns them into little bite-sized snacks for macrophages, so they are cleared very efficiently.

Ke Cheng, Randall B. Terry Jr. Distinguished Professor in Regenerative Medicine, North Carolina State University

The researchers pointed out the other three advantages of the LSC nanodecoys. First, non-invasive delivery of nanodecoys to the lungs through inhalation therapy is possible. Second, the nanodecoys are acellular, which means nothing lives inside, so they can be preserved easily and can remain stable for a longer time, allowing off-the-shelf use. Finally, LSCs are already being used in other clinical trials and, therefore, are more likely to be used in the near future.

By focusing on the bodys defenses rather than a virus that will keep mutating we have the potential to create a therapy that will be useful long-term. As long as the virus needs to enter the lung cell, we can keep tricking it.

Ke Cheng, Randall B. Terry Jr. Distinguished Professor in Regenerative Medicine, North Carolina State University

The study was published in the Nature Nanotechnology journal and was funded by the National Institutes of Health and the American Heart Association. Dr. Jason Lobo, a pulmonologist at UNC-CH, is the co-author of the study.

Video Credit: North Carolina State University.

Li, Z., et al. (2021) Cell-Mimicking Nanodecoys Neutralize SARS-CoV-2 and Mitigate Lung Injury in a Nonhuman Primate Model of COVID-19. Nature Nanotechnology. doi.org/ 10.1038/s41565-021-00923-2.

Source: https://www.ncsu.edu/

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Nanodecoy Therapy is an Effective Alternative to Neutralize SARS-CoV-2 Virus - AZoNano

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HCG Diet Plan ULTIMATE Guide | HCG Diet Info

Posted: June 23, 2021 at 2:08 am

What is the Hcg Diet Plan? (& how to do it right)

The Hcg Diet Plan is a doctor-supervised, rapid medical weight loss program that combines hormone therapy with whole food eating. Menu options are heavy in vegetables and lean proteins, as well as fruit options and limited grains. Allowed calories on the protocol, range from 500 to 1800 calories, depending on the protocol followed.

The original Hcg weight loss protocol follows a very specific food list that results in weight loss, but can teach healthy eating, portion control and establish healthy relationships with food. While the protocol was initially outlined by Dr. Simeons, modern day variations have become increasingly popular. This guide, focuses on the original protocol, with modern adaptations noted by the editor.

How the diet started Dr. Simeons, MD.

Dr. Albert Simeons was a world-renowned endocrinologist recognized for his pioneering work in tropical diseases. He was awarded the Red Cross Order of Merit for his advancement in the research and treatment of Malaria and honored for a number of research-breakthroughs. While working with severely malnourished women in India, Dr. Simeons discovered a link between the Hcg hormone, and its ability to utilize stored fat to nourish and deliver healthy children. After years of research, he was able to develop a protocol that utilized this effect of Hcg, to treat obesity, and published the groundbreaking manuscript, Pounds and Inches.

Here are a few basics for those who are ready to jump right in and start with the plan immediately. With these simple articles, you can easily get started today. Take note however, that anyone new to the plan, should read through this guide thoroughly, and NEVER proceed with the protocol without consulting a physician (FDA approved telemedicine Hcg programs are listed below.)

The Hcg Diet is a medical weight loss plan, and should ONLY be prescribed and overseen by a licensed medical doctor. While it can be challenging to find a local physician that specializes in Hcg hormone therapy, there are a few options available online, through FDA-approved telemedicine companies in the USA. These sources provide complete prescription Hcg kits for injections, drops and tablets/pills/pellets, and provide expert guidance throughout the duration of treatment.

Preparing for the plan, is absolutely essential and should not be skipped. Much like building a house, you want a solid foundation and to be prepared for the steps and challenges that come along with the protocol. In fact, most challenges can be avoided completely by reading the following articles before getting started.

These tools can be beneficial for those starting out on the plan for the first time. They are all free to download. We will be adding more here, so please check back often.

The Hcg protocol consists of 3 phases, with a newer 4th phase that has been added to the original protocol, being coined as P4, longterm maintenance. Each phase is extremely important and should not be skipped. The Loading Phase (P1) is 2 (in some cases, 3 days,) while Phase 2, the weight loss phase, can vary in length depending on your protocols specifics. For example, one Hcg sources protocol can differ from another such as 26 days or 29 days. Phase 3, the Transition Phase, lasts 3 weeks and is an expansion of increased calories and foods that do not include any sugars or starches. The 4th phase refers to life after the diets first 3 phases and includes a lifestyle of healthy choices learned while on the protocol. This includes exercise, portion control, clean eating and healthy living in general.

The HCG Diet Protocol consists of separate phases. Together, they are referred to as a round. Dieters typically lose 18 to 25 lbs per round (approximately 1 month.) If more weight is needed to be lost, there is a 3 week break after the final phase, and thenanother round is started. Rinse and repeat until goal weight is reached.

HCG Diet protocols include the following4 phases. Note on protocol variations: Some protocols actually include 3 and 4 as the same Maintenance phase and have only 3 phases total. Other protocols, including Dr. Simeons Original protocol, do not include phase 1, loading phase. This can be a personal preference, however we will say that the following phase example, has shown great results from our readers, and has certainly appeared to be the most successful.

Phase 1 is the loading phase. Also known as the preparation phase. This phase is not on all HCG Diet protocols but it is on most and is very popular. During this two day phase, the dieter eats as much healthy fats as possible in preparation for starting the next phase. They are also welcome to eat as many cheat foods as they would like, with the intention of satisfying cravings prior to beginning the next phase where these foods will not be allowed. Read more

Phase 2 of the HCG Diet is the weight loss phase. This begins on day 3 of taking HCG where the dieter adheres toa specifiedcalorie intake and carefully selected food list. For most dieters, this is the most challenging phase of the plan because there is very little room for error. Read more:

Phase 3 of the HCG Dietis at the end of HCG is discontinued and the same foods from phase 2 are still eaten, but increased slowly. In this stage, this is areintroduction period where calories and foods are slowly adjusted to maintain weight loss. Read more:

Phase 4 of the HCG Diet is the phase of continuing weight maintenance for life-long health and fitness.This is an essential part of the HCG diet and it actually begins during Phase 2. This is where you will begin to build the skills necessary for lifetime weight maintenance and healthy living. For example; reading labels as a habit (this will become 2nd nature and shouldntstop once you reach your weight loss goals. Also, portion control and learning to listen to your body. Read more about these skills and implement them starting NOW:

Hcg weight loss foods and recipes are the backbone of the Hcg weight loss program. Not only do the allowed foods help you to lose weight, but they also help get our body into a healthy state.

It is important to understand that while the Hcg hormone does NOT make you lose weight, it does change how your body loses weight, and creates a reaction in your body that allows for the rapid weight loss. It is the carefully selected Hcg Diet foods (see official list here (& dont forget to bookmark!) that is responsible for your weight loss; the Hcg just allows your body to continue to burn fat when it would normally go into starvation mode under the calorie restricted diet.

This is good news! This means the Hcg weight loss plan can be surprisingly versatile with the right recipes, and can work with any number of menus, foods sensitivities. The allowed foods are clear of processed and prepared foods and carefully measured for portion control. Instead of processed foods, the food list focuses on clean eating, and consists mostly of vegetables and healthy portions of lean protein, along with some, but limited, carbohydrates. To be clear, this is NOT a ketosis diet when done correctly, and in fact the amount of vegetables and fruit permitted, do not allow the body to go into ketosis. Compared to ketosis diets, this particular approach has been shown to average much higher weight loss rates that range from .5 to 1.5 pounds per day.

In a nutshell: The Hcg Diets strict eating guidelines focus on portion control, increased vegetables and proteins, and a food list that is comprised of clean, unprocessed foods.

The Original HCG Diet is known for its restrictive and unforgiving500 calorie VLCD (very low calorie diet.) Some versions of the diet have evolved to allowfor an HCG Diet expanded food list.

Learn what to eat on the HCG Diet and how to eat: Portion sizes, HCG Diet-friendly recipes for all phases, foods lists, plus HCG Diet cooking and shopping tips.

Learning to cook on the diet, can be a struggle for some patients, however, it is also an excellent opportunity to learn how to cook new foods that are clean, nutritious and healthy. Since the protocol does not allow foods that are processed or prepared (bye bye alcohol, fast food and frozen dinners) this can be an excellent path to learning how to prepare meals that will nourish your body, and make long term weight maintenance easy.

Take a look at our recipe section, and discover amazing Hcg Diet recipes for all meals that include Southwestern chicken, strawberry cupcakes, garlic baked shrimp, mouth-watering grilled asparagus, and chai beverages. While it may be intimidating to look at the allowed foods list and feel limited, it wont take long before you realize just how versatile and delicious it can be.

We have also included a list of our best recipe and cooking articles that cover everything from how to cook on the protocol, spices to use to increase your metabolism, tips for dining out and tips for eating during special occasions.

Sample menus and menu tips for the HCG Diet.

Hcg Diet Info allows your to buy your Hcg Kits and Programs online: Buy Hcg injections online here.

In the last few years, the FDA-approved telemedicine industry has grown and allowed doctors to prescribe and care for individuals wanting to follow the protocol. You can now safely buy Hcg kits online, that come with a complete program overseen by a medical doctor and Hcg weight loss experts and nutritionists. This has grown to be one of the most beneficial medical weight loss programs in the world now.

Tips for buying Hcg and Hcg weight loss programs: One of the first things to take into consideration when buying Hcg, is which form of Hcg you feel comfortable with, how soon you would like to start your diet, and the level of support you will need. The latter tends to be the biggest difference between various Hcg sources with some companies offering minimal support (better for veterans and pros that want to buy a bare bones Hcg kit to save money) and other companies offering extensive diet support, while yet another offering custom dosage and protocol support, and complete medical doctor hand-holding, along with a year of nutritionist services (even after the diet is completed.) These may seem like small differences but they can add up to be an extreme value for your money, as well as offer peace of mind.

The sources recommended in Hcg Diet Infooffer each of the acceptable choices that can be used with the original Hcg weight loss protocol: Hcg injections, Hcg Diet Drops (Prescription or Homeopathic), and Prescription Hcg Pellets. The Hcg Buy Guide also offers answers to dozens of frequently asked questions about buying Hcg Kits and Hcg weight loss programs online. Please note: Over the counter hormone free diet drops should NOT be used with the original protocol and can be dangerous if combined with the VLCD (very low calorie menu.) These over the counter drops have been addressed and dismissed largely by the FDA for good reason- they are NOT safe with the original protocol. Read about real vs fake Hcg Drops here, for more information.

The absolute best (&Free!) HCG Diet tips for reaching your weight loss goals safe and fast!

Exercise is an important part of healthy living, even without wanting to lose weight. While the original protocol insistedexercise was not necessary, most of the evolvedprotocols include and encourage a consistent exercise routine simply because it is a healthy lifestyle option and the benefits are many.

For those currently active, in most cases, it is ok to continue as usual, although some may find it useful to lighten their workout for the first week of being on the protocol. For those who are new to working out, a low impact daily workout of at least 20 minutes a day is recommended to start. Recommended activities include: walking (brisk), swimming, yoga (no hot yoga practices yet), and pilates. Level of activity is extremely light the first week of phase 2 on the HCG Diet and increases as the individual feels ready. It is highly advised that the chosen workouts are something enjoyable, and not something you dread doing every day.

The HCG Diet can be complicated and so specific,you are almost certain to experiencechallenges along the way. While it might not seem welcome, It is a large part of the learning process for long term managementsuccess. There will be temptation to stray from your planned diet, and there may even be times when you stray by accident. Yes, it can happen: Aunt Sally forgot to tell you she adds sugar toher famous holiday vinaigrettedressing, or the restaurant neglected to tell you theres bread crumb mixed right into the hamburger patty which you so carefully ordered without a bun. Of course theres the good old oops, I assumed that hot sauce was just hot sauce and didnt realize it had 9 grams of sugar. Theres your first lesson; always double-check ingredientsand dont eat it unless youre sure. A better lesson if you cant see all ingredients, dont eat it! The less processed foods you eat, the better. See, its all part of the big picture and building the skillsto be fit and thin for life.

Dr. Simeons manuscript, Pounds and Inches is the original book that outlines every detail of the Hcg weight loss protocol. Dr. Simeons has been very specific in his words, outlining all aspects of the diet. This includes the original 500 calorie menu, the effects of hCG on the body, hCG dosage, how to inject hCG, how to handle stalls and plateaus, and a solid overview transitioning from phase 2 to phase 3, which many dieters can find challenging.

Regardless of which version of the protocol the patient is following, it can still be helpful to read the manuscript. Not only does this allow the Hcg dieter to understand the intention of the diet, but it can also help establish a solid foundation of preparation, and help avoid challenges by answering many of the most frequently asked questions.

Our editor has taken the time to separate the original manuscript by chapter, making it easy to navigate and locate individual topics. We also offer an MP3 audio version (audiobook) of the Pounds and Inches manuscript, as well as a PDF version. These will be automatically sent to those who sign up for our newsletter but they can also be found here:

We realize this diet can bring a lot of questions, so please feel free to visit our two pages that cover the most frequently asked questions about the diet in general, and the more specific protocol-based questions. Questions and answers include topics on dosage amounts, weight loss averages, how to inject hCG, the differences between Hcg injections, drops and pellets, and so much more. After reading these pages, feel free to take your questions to the forums, where our expert moderators and coaches, as well as the countless veterans, will be more than happy to offer their support.

Most frequently asked questions:

Have questions about the plan and protocol? Need a little support, or just want to find a friendly face to share the experience? Join ourHCG Diet Forums, the largest HCG community on the web with over 100 thousand inspired members and growing. Join our monthly coaching and support groups, get answers to all your questions from expert coaches, or find a buddy to share your Hcg weight loss journey! The HDI forums are the best place to mingle with your fellow HCG Dieters and get answers in one place. There are also over 2 million pages of priceless information and resources in these forums, easily searchable and readily at your fingertips.

Author Info: Dr. Jen Larson, BSN, N.D. has a background in nursing and now a doctorate in natural medicine with a focus in holistic sports medicine and nutrition. She is considered to be an expert on medical weight loss.

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HCG Diet Plan ULTIMATE Guide | HCG Diet Info

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