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Stem cells: What they are and what they do – Mayo Clinic

Posted: June 6, 2021 at 2:42 am

Stem cells: What they are and what they do

Stem cells and derived products offer great promise for new medical treatments. Learn about stem cell types, current and possible uses, ethical issues, and the state of research and practice.

You've heard about stem cells in the news, and perhaps you've wondered if they might help you or a loved one with a serious disease. You may wonder what stem cells are, how they're being used to treat disease and injury, and why they're the subject of such vigorous debate.

Here are some answers to frequently asked questions about stem cells.

Stem cells: The body's master cells

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Stem cells are the body's master cells. All other cells arise from stem cells, including blood cells, nerve cells and others.

Stem cells are the body's raw materials cells from which all other cells with specialized functions are generated. Under the right conditions in the body or a laboratory, stem cells divide to form more cells called daughter cells.

These daughter cells either become new stem cells (self-renewal) or become specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle cells or bone cells. No other cell in the body has the natural ability to generate new cell types.

Researchers and doctors hope stem cell studies can help to:

Generate healthy cells to replace diseased cells (regenerative medicine). Stem cells can be guided into becoming specific cells that can be used to regenerate and repair diseased or damaged tissues in people.

People who might benefit from stem cell therapies include those with spinal cord injuries, type 1 diabetes, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, heart disease, stroke, burns, cancer and osteoarthritis.

Stem cells may have the potential to be grown to become new tissue for use in transplant and regenerative medicine. Researchers continue to advance the knowledge on stem cells and their applications in transplant and regenerative medicine.

Test new drugs for safety and effectiveness. Before using investigational drugs in people, researchers can use some types of stem cells to test the drugs for safety and quality. This type of testing will most likely first have a direct impact on drug development first for cardiac toxicity testing.

New areas of study include the effectiveness of using human stem cells that have been programmed into tissue-specific cells to test new drugs. For the testing of new drugs to be accurate, the cells must be programmed to acquire properties of the type of cells targeted by the drug. Techniques to program cells into specific cells continue to be studied.

For instance, nerve cells could be generated to test a new drug for a nerve disease. Tests could show whether the new drug had any effect on the cells and whether the cells were harmed.

Researchers have discovered several sources of stem cells:

Embryonic stem cells. These stem cells come from embryos that are three to five days old. At this stage, an embryo is called a blastocyst and has about 150 cells.

These are pluripotent (ploo-RIP-uh-tunt) stem cells, meaning they can divide into more stem cells or can become any type of cell in the body. This versatility allows embryonic stem cells to be used to regenerate or repair diseased tissue and organs.

Adult stem cells. These stem cells are found in small numbers in most adult tissues, such as bone marrow or fat. Compared with embryonic stem cells, adult stem cells have a more limited ability to give rise to various cells of the body.

Until recently, researchers thought adult stem cells could create only similar types of cells. For instance, researchers thought that stem cells residing in the bone marrow could give rise only to blood cells.

However, emerging evidence suggests that adult stem cells may be able to create various types of cells. For instance, bone marrow stem cells may be able to create bone or heart muscle cells.

This research has led to early-stage clinical trials to test usefulness and safety in people. For example, adult stem cells are currently being tested in people with neurological or heart disease.

Adult cells altered to have properties of embryonic stem cells (induced pluripotent stem cells). Scientists have successfully transformed regular adult cells into stem cells using genetic reprogramming. By altering the genes in the adult cells, researchers can reprogram the cells to act similarly to embryonic stem cells.

This new technique may allow researchers to use reprogrammed cells instead of embryonic stem cells and prevent immune system rejection of the new stem cells. However, scientists don't yet know whether using altered adult cells will cause adverse effects in humans.

Researchers have been able to take regular connective tissue cells and reprogram them to become functional heart cells. In studies, animals with heart failure that were injected with new heart cells experienced improved heart function and survival time.

Perinatal stem cells. Researchers have discovered stem cells in amniotic fluid as well as umbilical cord blood. These stem cells also have the ability to change into specialized cells.

Amniotic fluid fills the sac that surrounds and protects a developing fetus in the uterus. Researchers have identified stem cells in samples of amniotic fluid drawn from pregnant women to test for abnormalities a procedure called amniocentesis.

More study of amniotic fluid stem cells is needed to understand their potential.

Embryonic stem cells are obtained from early-stage embryos a group of cells that forms when a woman's egg is fertilized with a man's sperm in an in vitro fertilization clinic. Because human embryonic stem cells are extracted from human embryos, several questions and issues have been raised about the ethics of embryonic stem cell research.

The National Institutes of Health created guidelines for human stem cell research in 2009. The guidelines define embryonic stem cells and how they may be used in research, and include recommendations for the donation of embryonic stem cells. Also, the guidelines state embryonic stem cells from embryos created by in vitro fertilization can be used only when the embryo is no longer needed.

The embryos being used in embryonic stem cell research come from eggs that were fertilized at in vitro fertilization clinics but never implanted in a woman's uterus. The stem cells are donated with informed consent from donors. The stem cells can live and grow in special solutions in test tubes or petri dishes in laboratories.

Although research into adult stem cells is promising, adult stem cells may not be as versatile and durable as are embryonic stem cells. Adult stem cells may not be able to be manipulated to produce all cell types, which limits how adult stem cells can be used to treat diseases.

Adult stem cells also are more likely to contain abnormalities due to environmental hazards, such as toxins, or from errors acquired by the cells during replication. However, researchers have found that adult stem cells are more adaptable than was first thought.

A stem cell line is a group of cells that all descend from a single original stem cell and are grown in a lab. Cells in a stem cell line keep growing but don't differentiate into specialized cells. Ideally, they remain free of genetic defects and continue to create more stem cells. Clusters of cells can be taken from a stem cell line and frozen for storage or shared with other researchers.

Stem cell therapy, also known as regenerative medicine, promotes the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. It is the next chapter in organ transplantation and uses cells instead of donor organs, which are limited in supply.

Researchers grow stem cells in a lab. These stem cells are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells.

The specialized cells can then be implanted into a person. For example, if the person has heart disease, the cells could be injected into the heart muscle. The healthy transplanted heart muscle cells could then contribute to repairing defective heart muscle.

Researchers have already shown that adult bone marrow cells guided to become heart-like cells can repair heart tissue in people, and more research is ongoing.

Yes. Doctors have performed stem cell transplants, also known as bone marrow transplants. In stem cell transplants, stem cells replace cells damaged by chemotherapy or disease or serve as a way for the donor's immune system to fight some types of cancer and blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma. These transplants use adult stem cells or umbilical cord blood.

Researchers are testing adult stem cells to treat other conditions, including a number of degenerative diseases such as heart failure.

For embryonic stem cells to be useful in people, researchers must be certain that the stem cells will differentiate into the specific cell types desired.

Researchers have discovered ways to direct stem cells to become specific types of cells, such as directing embryonic stem cells to become heart cells. Research is ongoing in this area.

Embryonic stem cells can also grow irregularly or specialize in different cell types spontaneously. Researchers are studying how to control the growth and differentiation of embryonic stem cells.

Embryonic stem cells might also trigger an immune response in which the recipient's body attacks the stem cells as foreign invaders, or the stem cells might simply fail to function normally, with unknown consequences. Researchers continue to study how to avoid these possible complications.

Therapeutic cloning, also called somatic cell nuclear transfer, is a technique to create versatile stem cells independent of fertilized eggs. In this technique, the nucleus, which contains the genetic material, is removed from an unfertilized egg. The nucleus is also removed from the cell of a donor.

This donor nucleus is then injected into the egg, replacing the nucleus that was removed, in a process called nuclear transfer. The egg is allowed to divide and soon forms a blastocyst. This process creates a line of stem cells that is genetically identical to the donor's cells in essence, a clone.

Some researchers believe that stem cells derived from therapeutic cloning may offer benefits over those from fertilized eggs because cloned cells are less likely to be rejected once transplanted back into the donor and may allow researchers to see exactly how a disease develops.

No. Researchers haven't been able to successfully perform therapeutic cloning with humans despite success in a number of other species.

However, in recent studies, researchers have created human pluripotent stem cells by modifying the therapeutic cloning process. Researchers continue to study the potential of therapeutic cloning in people.

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Stem Cell Therapy for Knee Pain: What Patients Should Know

Posted: June 6, 2021 at 2:42 am

Theres been a lot of talk about stem cell therapy in recent yearsbut what is it, exactly? How does it work, and is it an effective treatment for knee pain?

Knee pain affects over 25% of adults in the US, and can affect anyone of any age. While physical therapy and prescription medications can be used to effectively treat mild pain, those with more severe pain may require surgery.

For patients who are struggling to manage knee pain but would like to delay knee replacement surgery, stem cell therapy may be an option. Dr. Daniel E. Murphy, an orthopedic specialist here at Florida Medical Clinic wants to help patients understand stem cell treatment, its uses and limitations, and how it may help some find relief from knee pain caused by injury or arthritis.

Stem cell therapy, also called orthobiologic treatment when talking about treating orthopedic conditions, is a special kind of medical treatment that uses stem cells and growth factors to reduce pain.

In the human body, most cells have one job. For example, a red blood cell cant do the same job as a skin cell. However, stem cells are a special kind of cell that have the potential to divide into any other type of cell found in the body, like a liver cell or a heart muscle cell. That means they can perform many different jobs.

In some laboratories, scientists have been able to help some patients rebuild damaged tissue using stem cells. While that success has been limited to lab settings, Dr. Murphy says doctors are still studying if it can be used to help everyday patients regenerate lost tissue. Thats because theres still a lot we dont know about stem cells and how they can be manipulated to work in different parts of the body.

Scientists arent sure if or how stem cell treatment can help patients regrow lost cartilage or bone density, which may be at the root of many cases of knee pain. However, we do know that patients suffering from knee pain may find relief with treatment.

You may be wary of stem cells if youve heard about some of the controversy surrounding how theyre sourced. Its true that some kinds of stem cells are sourced from donated blastocysts (early-stage embryos) that are just a few days old, but these kinds are not used for orthobiologic treatment.

Instead, orthobiologic therapy for knee pain most commonly uses stem cells from adult patients themselves by taking samples of bone marrow and other tissues.

During treatment, a doctor will take samples of stem cells from other parts of your body and reimplant them into an injured area. For knee pain, that may involve taking sample cells from bone marrow or fat tissue and injecting them into knee joints.

Your doctor will always discuss the source of your stem cells with you before starting treatment and will not inject you with any substance you do not consent to.

Stem cell therapy may help reduce pain but is not a magic solution for any disease or condition. Be wary of any physician or clinic that claims stem cell therapy can completely reverse or heal an orthopedic condition.

As of 2020, the FDA has only approved stem cell treatment for a few kinds of diseases, including some cancers and blood disorders. However, reinjecting a patients own stem cells back into their body is permitted as a therapy for orthopedic purposes.

Many patients do find relief from pain and stiffness caused by knee injuries or osteoarthritis with orthobiologic treatment. It may also be a good alternative to knee replacement surgery in some patients. There has been some evidence that orthobiologic injections reduce knee pain in patients by as much as 75%, which was supported by a follow-up study. Scientists believe this may be because injected stem cells can help reduce inflammation.

Stem cell therapy and orthobiologic treatment are still burgeoning medical fields. Theres a lot were still learning about their uses, benefits, and drawbacks. We dont know for certain if it works for things like cartilage regeneration or healing spinal cord injuries.

Despite this, Dr. Murphy reports that many patients do find orthobiologic treatment to be helpful for their knee paineven if it doesnt reverse bone or cartilage loss. Some of the benefits may include:

The majority of patients who receive stem cell treatment for knee pain experience quick recovery times and little to no adverse side effects. That being said, its important to know the potential drawbacks:

Your doctor should fully discuss the pros and cons of this treatment with you before you receive any injections. Some patients may not be eligible based on certain risk factors.

In combination with lifestyle changes and other treatments, many patients find relief from knee pain with stem cell therapy. That being said, its important to discuss your options and risk factors with your doctor to determine what kind of treatment path is right for you.

If youre considering a stem cell injection, make sure your doctor is a board-certified orthopaedic surgeon before you proceed. Your physician should be listed on the American Academy of Orthopaedic Surgeons website at aaos.org.

To learn more about stem cell therapy for knee pain, schedule an appointment with Dr. Murphy today. Virtual appointments are also available.

Disclaimer: This blog is not intended to substitute professional medical advice. Always talk with your doctor before starting or stopping medications or treatments.

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High Altitude Balloons Return to Near-Space from UNO – University of Nebraska Omaha

Posted: June 6, 2021 at 2:40 am

Students from the University of Nebraska at Omaha have once again sent experiments to near-space through two high-altitude balloon launches this time in support of a unique opportunity to launch a small satellite into orbit.

UNOs TED/STEM 8860 Invention & Innovation in Engineering Education class joined with the University of Nebraska-Lincolns (UNL) Nebraska Big Red Satellite team and the UNL Aerospace eXperimental Payload (AXP) team to launch high-altitude balloons in the final weeks of the Spring 2021 semester.

The launches were conducted as a precursor to the NASA CubeSat Launch Initiative which will launch and place a small student-created satellite into earths orbit a first for the state of Nebraska. The Big Red Satellite team is comprised of UNL undergraduate engineering students who also mentor Nebraska middle and high school students in near-space STEM experiments.

Ensuring successful launches now and in the future meant drawing on the experience and expertise of Derrick Nero, Ed.D., assistant professor of teacher education at UNO. Nero supported AXP and the Big Red Satellite Team through technical and logistical advisement including staging and balloon fill procedures, design considerations, and meeting FAA requirements for unmanned free balloons.

Design considerations were a particular challenge as breezy weather made launches difficult. The teams prepared for a dual balloon launch from the Strategic Air and Space Museum near Ashland, Nebraska on April 24, 2021. Congressman Don Bacon was on hand to deliver remarks, congratulate them on their selection for the NASA CubeSat program, and wish all teams the best of luck.

Mother Nature did her best to keep the balloons on the ground. The UNO team successfully launched one balloon complete with test payloads to track the balloons position and record data. However, the wind proved to be too much for the second balloon. The teams were forced to give the second balloon another try on a later date when weather conditions were more ideal.

While a minor setback, Nero believes that these less-than-optimal weather conditions provided students with an extra chance to apply what they were learning. Challenges such as less ideal weather conditions and payload or equipment issues provide great learning opportunities for students in preparation: Creating alternate plans, performing real-time troubleshooting and decision-making, and critically reviewing for procedures optimization, Nero said.

And troubleshoot they did. The second balloon was launched successfully from UNOs campus the following week despite another windy spring Nebraska day. Between the two launches, both balloons rose to the upper levels of the Earths atmosphere or approximately 70,000 feet. Altogether, six payloads made the journey to near-space: Three of the payloads were projects of the Big Red Satellite team of middle- and high-school students while an additional three payloads were projects of the UNL Aerospace eXperimental Payloads (AXP) team.

The lessons learned in these launches will prove valuable as the Big Red Satellite Team gears up for successful NASA CubeSat Launch in the years to come. The payloads enabled students to study various effects of radiation on food, solar cells, and testing hardware in preparation for the CubeSat project.

NASAs CubeSat Launch Initiative selects small satellite payloads built by universities, high schools and non-profit organizations to fly on upcoming launches. Through innovative technology partnerships, NASA provides CubeSat developers a low-cost pathway to conduct scientific investigations and technology demonstrations in space, thus enabling students, teachers and faculty to obtain hands-on flight hardware development experience.

UNO is excited to assist the Big Red Satellite Team as they continue to design, test, and improve its platform, payloads, and practices to successfully deploy a nanosatellite in support of NASA's CubeSat Launch Initiative, Nero said.

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Nanomedicine is transforming healthcare innovation – Korea IT Times

Posted: June 6, 2021 at 2:39 am

COVID-19s outbreak has coincided with investments flooding into nanomedicine healthcare companies. The World Nano Foundation and Nano Magazine have highlighted a report by marketdataforecast.com that the global nanomedicine market, worth $141.34 billion in 2020, will rise to $258.11bn by 2025.

The report also highlights a huge upsurge of investment support from governments and funds to develop nano therapies for vaccines, diagnostic imaging, regenerative medicine, and drug delivery following the impact of COVID-19.

Furthermore, nanomedicine offers huge advantages for wider healthcare also impacted by the pandemic and Long-COVID after-effects upon cardiovascular, respiratory, neurological, immunological-related diseases.

This aligns with investment monitoring platform Pitchbooks forecast that health tech investment overall will top $10 trillion by 2022 and that nanomedicine investment has grown the sector by 250% in the last five years.

Median nanotech healthcare companies' deal sizes have also doubled since 2019, from 1 million to 2m in the last 12 months, while the number of deals in 2020 was greater than ever, overtaking 100 deals in a single year for the first time.

Investment is already aiding innovation as nanotech researchers and scientists work to improve biomedical devices such as prosthetics, provide new cancer treatments, and develop bone healing therapies, along with more innovations that could transform global healthcare.

Nanotech researchers have found nanobodies that block the COVID-19 and, potentially, other coronaviruses from entering cells and developed mask designs at nanoscale making them both cheaper and more effective.

The fast global response to the pandemic was also enabled by nanotechnology, being pivotal in Pfizer and AstraZeneca vaccine development and Innova Medical Groups 30-minute lateral flow COVID tests.

World Nano Foundation co-founder Paul Stannard said COVID-19 highlighted weaknesses in healthcare systems across the developed world, proving that long-term, innovative solutions are needed to enable change and prevent future pandemics, with nanomedicine playing an ever greater role in this transformation of global healthcare.

And while impressed by rising investments in and recognition for the nanotech sector, he warned against any let-up in this trend:

Nanotechnology is not only crucial to our current healthcare systems, but researchers and scientists in this field are on the cusp of therapies, devices, and innovation that will revolutionize how we move forward.

To ensure pandemic preparedness, high-quality healthcare, and longevity, we must invest in nano healthtech and care innovations.

His message was echoed by Kojo Annan (son of late and former UN secretary-general Kofi Annan) who is a general partner in the Luxembourg-based Vector Innovation Fund, which recently launched a sub-fund raising an initial $300m for pandemic protection and preparedness.

Annan said: A virtuous circle is developing between investment and healthtech.

Lately, we have seen the development of multiple vaccines, acceleration of technologies linked to decoding the genome, the rise of nanomedicine and the use of artificial intelligence to monitor infectious diseases and new pathogens.

More investment in sustainable healthtech funding can only accelerate this trend, bringing fairer and global distribution of healthcare, greater affordability, and preventive and early intervention healthcare, all ultimately improving the longevity of life.

The pandemic has also transformed telemedicine investment and demonstrated that nonsense and innovation could deliver more resilient societies and ecosystems for healthcare.

Written by Steve Philp of The World Nano Foundation.

Korea IT Times

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The Future of Cancer Treatment Using Nanotechnology – AZoNano

Posted: June 6, 2021 at 2:39 am

Image Credit:Giovanni Cancemi/Shutterstock.com

Traditional cancer therapies pose the risk of causing damage to healthy tissue as they work to eradicate cancer cells. Scientists are currently working on therapeutics based on nanotechnology to overcome this limitation and increase survival probabilities in several types of cancer.

Nanotechnology enhances chemotherapy and reduces its adverse effects by guiding drugs to selectively target cancer cells. It also guides the surgical resection of tumors with higher levels of accuracy and enhances the efficacy of radiotherapies and other current treatment options. The result is decreased risk to the patient and enhanced survival probabilities.

Researchers are developing novel therapeutics with newly discovered nanoparticles that have novel properties to be leveraged in medical science. While tiny in size, nanoparticles encapsulate small pharmaceutical compounds. The relatively large surface area of nanoparticles allows them to be decorated with ligands, strands of DNA and RNA, peptides, or antibodies. These add-ons give the nanoparticle additional functionality that enhances the therapeutic effect or helps direct a nanoparticle to a specific location. As a result, nanoparticles facilitate combination drug delivery, multi-modality treatment, and theranostic, action (combined therapeutic and diagnostic). The energy absorption and re-radiation properties of nanoparticles also allows them to improve laser ablation and hyperthermia applications, which disrupt diseased tissue.

Nanoparticle research in oncology is currently progressing rapidly, with several major lines of enquiry emerging such as the development of nanoparticle packages, active pharmaceutical ingredients to facilitate the exploration of a broader range of active ingredients, and the establishment of immunogenic cargo and surface coatings as adjuvants to nanoparticle-mediated therapy, radio- and chemotherapy, and stand-alone therapies.

Below, we discuss the major applications of nanotechnology in oncology.

The primary use of nanotechnology in oncology is within the delivery of drugs. Much research has shown that nanotechnology has successfully been used to design multiple systems that improve the pharmacokinetics of a pharmaceutical and reduce the related toxicities. These systems limit the adverse events of the drugs and augment a patients survival chances. They also allow chemotherapies to be more selective as they help deliver the drugs to the specific tumor tissues. These methods involve the development of nano-sized carriers that encompass and deliver the drug to its target.

There are numerous examples of these types of systems. One recent methodology has been used to increase the efficacy of chemotherapy drugs used to treat bowel cancer. The results of clinical trials suggested that the nanoparticle delivery system could help increase survival rates of bowel cancer, the third most common cancer in the world, by helping the delivery of chemotherapy drugs directly to the diseased organs. In studies with animals, the system was proven to be effective at delivering Capecitabine (CAP) to the diseased cells while bypassing healthy cells. This reduced toxic side effects and enhanced the efficacy of tumor reduction activity.

Recent research has demonstrated the efficacy of nano-sized carriers in delivering alternative, herbal-based therapeutics. Scientists have created a novel targeted therapy to treat triple-negative breast cancer (TNBC) that utilizes nano-carriers to help deliver gambogic acid (GA), a Chinese medicine compound, to specific targets. Studies have shown that the novel methodology was effective at enhancing the anti-cancer effect of GA and limiting damage to healthy tissue. As a result, the use of GA may emerge as a more effective therapeutic option for the treatment of TNBC.

Another encouraging area of nanotechnology in oncology is its use in enhancing immunotherapy. While immunotherapy has already been established as an exciting and potentially highly effective treatment option for various types of cancer, the proportion of patients who respond positively to immunotherapy remains low, with only around 15% of patients demonstrating an objective response rate across indications. This is linked to the multiple immune-evasion methods of the tumor.

To help boost the immune systems efficacy against cancer, nanotechnology is being leveraged to manage the spatiotemporal control of the immune system. The idea is that naturally, the immune system is spatiotemporally controlled. Therefore, to work effectively, therapies that impact the immune system should also be spatiotemporally controlled. Recent research has demonstrated that nanoparticles and biomaterials allow scientists to control the delivery, pharmacokinetics, and location of immunomodulatory compounds, generating responses that cannot be elevated by administering the same compounds within a solution.

Radiotherapy is administered to around half of cancer patients at some point during their treatment. Radiotherapy is effective at reducing the size of tumors by exposing them to high-energy radiation, however, this radiation can also damage healthy cells. Scientists have been working on enhancing the effect of radiotherapy, as well as developing novel externally applied electromagnetic radiation. As a result, it is possible that the combination of nanotechnology and radiotherapy may produce more effective results than radiotherapy alone.

How nanoparticles could change the way we treat cancer | Joy WolframPlay

Video Credit: TED/YouTube.com

HKBU and Cornell University develop novel targeted therapy for breast cancer with nanotechnology and Chinese medicine. EurekAlert!. Available at: https://www.eurekalert.org/pub_releases/2021-05/hkbu-hac051121.php

Goldberg, M., 2019. Improving cancer immunotherapy through nanotechnology. Nature Reviews Cancer, 19(10), pp.587-602. https://www.nature.com/articles/s41568-019-0186-9

Targeting Bowel Cancer with Nanotechnology. GEN. Available at: https://www.genengnews.com/topics/targeting-bowel-cancer-with-nanotechnology/

van der Meel, R., Sulheim, E., Shi, Y., Kiessling, F., Mulder, W. and Lammers, T., 2019. Smart cancer nanomedicine. Nature Nanotechnology, 14(11), pp.1007-1017. https://www.nature.com/articles/s41565-019-0567-y

Disclaimer: The views expressed here are those of the author expressed in their private capacity and do not necessarily represent the views of AZoM.com Limited T/A AZoNetwork the owner and operator of this website. This disclaimer forms part of the Terms and conditions of use of this website.

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Thomas Jefferson Awards Highlight Research and Service to the University – UVA Today

Posted: June 6, 2021 at 2:39 am

Petri, who serves as Wade Hampton Frost Professor of Medicine and is stepping down as chief of the Division of Infectious Diseases and International Health at UVA, has worked at the University continuously for more than 30 years as a physician, scientist and educator. Last year, he shifted his work to pursue understanding of the coronavirus SARS-CoV-2. He became a trusted voice of reason and comfort to the UVA community extending his knowledge to the nation via online media during the stressful time of the pandemic.

No discussion of Bill would be complete without mentioning what he has done over the last year-plus, during the pandemic, Executive Vice President and Provost Liz Magill said, in presenting the award to him. I can say Jim [Ryan] and I are grateful for his constant availability, tenacity and servant leadership throughout this dark time.

Petri isnt just good at explaining science. Hes also been at the forefront of research, leading a multi-center team effort. He has applied his expertise in vaccine development to produce a mucosally administered, nano-formulated vaccine against the virus responsible for the COVID-19 illness. In addition to his design of the vaccine technology, he is also a most adept and capable team scientist, leading a multicenter effort in this timely, important work, as the citation notes.

Among his responses to this pandemic, he has cared for multiple patients infected with COVID-19, and along the way, educated numerous medical students and young physicians on its medical management.

An expert in infectious diseases, he has focused on several gastrointestinal illnesses and their impact on peoples health and lives, particularly children. Magill pointed out that he is world-renowned for this research, adding, None other than Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases at the NIH and himself a household name, said, Petri is the worlds premier investigator on diarrhea as well as a consummate physician-scientist, training program director, and institutional leader.

Magill said, His research and publications on understanding and treating these diseases have had life-changing impact for millions of patients the world over.

At UVA, he earned his medical degree and a Ph.D. in microbiology, as well as fellowship training in infectious diseases in the School of Medicine, before returning to join the faculty.

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Third parties in the U.S. What options do voters have? – Deseret News

Posted: June 6, 2021 at 2:37 am

Tired of the Republican Party? Fed up with the Democrats? Dont despair. There are dozens of political parties out there begging for your attention, including many you probably never knew existed.

At a time of increasing dissatisfaction with the major parties, voters appear to be shopping for alternatives, both nationally and on the state level.

People join third parties for a variety of reasons. Some are dissatisfied with the parties in power. Others are looking for an organization that better represents their personal political philosophies. Some want to push a single issue.

Regardless of the reason, political parties primarily exist to get candidates elected who share ideological and policy goals. On that front, nontraditional parties continue to be crushed by red and blue behemoths.

The long-established Libertarian, Green and Constitution parties are well known. In fact, Libertarian Gary Johnson did better in 2016 than any third-party presidential candidate since Ross Perot under the Reform Party 20 years earlier. State-level minor party candidates have also made inroads in some states, though it hasnt necessarily resulted in election wins.

But there is also a host of more obscure or single-issue parties on the menu of American politics.

Take the Transhumanist Party. Trans what? Transhumanist.

The party, according to its website, supports significant life extension achieved through the progress of science and technology; a cultural, societal, and political atmosphere informed and animated by reason, science, and secular values; and efforts to use science, technology, and rational discourse to reduce and eliminate various existential risks to the human species.

Then theres the United States Pirate Party. It has nothing to do with Capt. Jack Sparrow or that faux holiday in September where people say argh or matey. It does, however, have something to do with piracy. The Pirate Party aims to reform intellectual property laws, foster true governmental transparency, and protect privacy and civil liberties.

No political party outside of the Democrats and Republicans can currently claim a member of Congress, though there are two independents in the U.S. Senate, both of whom caucus with the Democrats.

Talk of a third major political party heated up recently among some prominent conservatives who are disillusioned with the fractured GOP, including 2016 independent presidential candidate Evan McMullin, Should they form a new party, the odds of putting someone in office are decidedly against them.

A Gallup poll released in February found support for a third political party in the United States at a high point. The survey found 62% of adults say the parties do such a poor job representing the American people that a third party is needed.

The poll was conducted before news reports that dozens of government officials in prior Republican administrations were discussing an anti-Donald Trump third political party, according to Gallup.

Some Republican voters in Utah are concerned about Trumps influence in the GOP, said Chris Karpowitz, co-director of the Center for the Study of Elections and Democracy at Brigham Young University.

The U.S. Capitol insurrection and, to a lesser extent, the booing of Sen. Mitt Romney at the Utah GOP convention, have raised worries about where the party is headed and what it stands for, he said. The events of the Trump era has resulted in young Utahns being less attached to the Republican Party, he said.

Whether that decreased willingness to identify with the Republican Party benefits third parties is an open question, Karpowitz said.

Nontraditional parties might be more attractive to some who are not ready to become Democrats, but most voters care about electability, and thats where third parties struggle, he said.

Only one third-party candidate, William Carney, has won a U.S. House election since 1960. New Yorkers voted Carney in as a member of the Conservative Party of New York State in 1979. He switched to the Republican Party in 1985.

Another Conservative Party candidate in New York, James Buckley, served one term in the U.S. Senate before losing reelection as a Republican in 1977. Former Sen. Joe Lieberman won reelection in a party created by his supporters, Connecticut for Lieberman, after losing the 2006 Democratic nomination.

The success rate in the modern era has not been good on a national level for third-party candidates.

But what about on a state level?

The track record isnt good there either, with one notable exception.

A Deseret News review of 50 state legislatures showed only four current officeholders from outside the two major parties a Libertarian in Wyoming, a Libertarian in Maine who switched from the GOP after being elected, a Working Families Party member in New York and member of the Independence Party of New York. There are also a few independents here and there.

But the Vermont General Assembly has more members from a minor party than the rest of the statehouses combined.

The Vermont Progressive Party is perhaps the most effective nontraditional party in the country.

Seven members of the Vermont House of Representatives and two state senators are Progressives. The Vermont House formally recognizes the Progressive caucus alongside the Democrats and Republicans.

In addition, the party holds a plurality on the 12-member Burlington City Council, with six members. (Four Democrats and two independents maintain the other seats). Progressives also held the mayors office for nearly 30 years.

Weve been successful because we primarily focus on local and legislative races, said Josh Wronski, Vermont Progressive Party executive director.

Though it homes in on local races, the Progressive Party does claim a big name: Bernie Sanders. Hes listed as a Progressive endorsed independent on the partys website.

Work closely with him, Wronski said. He accepts our nomination and politely chooses to run as an independent.

The Vermont Progressive Party also does well partly because of a thing called fusion voting. The practice gives candidates the ability to run on multiple party tickets. The parties are listed separately on the ballot but votes for the candidate are pooled. Only eight states in the country allow electoral fusion or multi-party nominations.

Progressives in the Vermont legislature are officially listed as Progressive/Democrat. Another seven members are listed as Democrat/Progressive.

Wronski said fusion voting has been a good way for the party to reach voters who have the perception that there are only Democrats and Republicans.

It has been a really good way to break through that and say were willing to work with not necessarily the Democratic establishment leaders but with Democratic voters who havent been exposed to the kind of work were doing, he said. That has absolutely been effective.

In Utah, Jim Bennett, the son of the late Republican Sen. Bob Bennett, and BYU political science professor Richard Davis, a Democrat, grew weary of extreme views co-opting their parties. They and other disaffected Republicans and Democrats formed the United Utah Party in 2017 to carve out a middle ground in the state.

As of this month, the party had only 2,501 registered members, according to the Utah elections office. Registered Republicans number more than 909,000, and Democrats 270,000 but there are 556,000 unaffiliated voters in the state.

Weve got a niche here that weve established, said Davis, who served two terms as the centrist partys chairman. His involvement in the fledgling party spurred him to look deeper into third parties resulting in a book last year titled Beyond Donkeys and Elephants: Minor Political Parties in Contemporary American Politics.

A United Utah candidate has yet to win an election. Party candidates captured a slightly smaller percentage of the overall vote in the state in 2020 compared to 2018, as the COVID-19 pandemic hampered their campaign efforts.

While the percentage was smaller, the number of votes cast for United Utah hopefuls was up last year, including more than 173,000 for its candidate for state auditor.

We saw that as progress given the fact that were still not known, Davis said.

Davis said hed like to have fusion voting in Utah to help get more moderate candidates elected to office rather than those who appeal to the more extreme Republican and Democratic bases.

In states where its used, third parties typically do better, Davis said. Unfortunately, theres not much encouragement on the part of Republicans and Democrats to do that.

Davis wonders if former Utah Rep. Ben McAdams, a conservative Democrat, would have benefitted from nominations in the Democratic and United Utah parties. He also thinks GOP Sen. Mitt Romney could have a sort of hedge with a United Utah nomination if he were to lose a Republican primary.

Fusion voting has popped up in the Utah Legislature a couple of times in the past, but never went anywhere, said Justin Lee, state elections director.

While the United Utah Party often inserts itself in debates on the issues of the day, its voice, like most third parties, goes largely ignored.

Too often the media can overlook the efforts of parties like us, Wronksi said.

For example, in 2008 the Vermont Progressive Party candidate for governor finished second in a three-way race. But network news outlets listed him as other next to the Democrat and the Republican even though he bested one of the major party candidates.

Some minor parties have tried to find strength in numbers. At least nine independent parties scattered across the country merged to form the Alliance Party over the past three years. Davis said the United Utah Party declined to join because it didnt care for the new partys presidential nominee and it prefers to concentrate its efforts on state and local races.

A third partys existence can also be tenuous. Many states require political parties to win a certain percentage of the overall vote in an election to maintain status as a recognized party. The Moderate Party in Rhode Island failed to do so in 2019, leaving officials to notify about 4,000 registered party members that they were now unaffiliated.

And whether you call them third parties, nontraditional parties or minor parties, not everything has to be red or blue.

Giraffe Party, anyone?

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Building the Ark – Architecture – E-Flux

Posted: June 6, 2021 at 2:37 am

Midway through my life, I wake to find myself in a techno-dystopia, with no sense of where my proper pathway has gone. I have a muse, but no mentor to guide me through all the circles of this labyrinth, this global metropolis I have managed to avoid until now. My domestication settles over me like a nylon shirt, like rolls of fat around my belly; like a cybernetic key for doors to places I dont want to go but have to if I want my family to eat and be sheltereda key that shuts away my mind from the world and keeps it locked in my brain.

I cant feel for knowledge anymore, not from my belly or through my feet from the living land. So instead, I try to make sense of things. But that doesnt work, so I turn it around and try to sense-make. But I dont know what that is, so I type it into the device that is my key to this world (war) of information and I make friends through that door.

Theyre stoics and I like their sense of humor. I havent read Marcus Aurelius, so I dont know if they are practicing kindness; I just think they are kind. Daniel has a brain like a planet and he says to me, First principles, Tyson. What is each thing within itself? What is its nature? What does it do, this civilization you despise?

Maybe Ive found my Virgil to guide me through this.

It kills people. It kills land.

No! That is incidental. What is the first and principal thing it does, what need does it serve by killing?

Matricidal rage. Fear of death. Tiny dicks

No, it covets. That is its nature. And how do we begin to covet, Tyson? Do we seek out things to covet? No. We begin by coveting what we see every day.

Lightbulb! I can see it, I can see it; they never felt superior at all, they never believed it for a second. They did not pity us or feel disgust, they was just jelly. Bah. If thats what your enlightenment gets you, then I dont want any of it.

But my new friends seem to have some bits and pieces from their Age of Reason that they want to keep, that might really be worth keeping. I think some of their algorithms are off, because of bad Paleolithic baseline data. I work to correct this in their games and on their commons, and find the skeleton of an Ark emerging. Did we make this one or dig it up on a mountain? I cant quite remember.

And dont worry, they say, were going to sense-make the fuck out of this imperialism right now. Jordan and Jim and Jamie and Brett and Eric are all going in, full tactical gear. I just have to finish up some interviews and loose ends.

But fuck me, they went to the wrong house and I went to the right one, and its there and hideous and all, It signs away its thoughts and land or else we take its kids again. And its Cook and Darwin and Deakin and its eyes are red and it can see in the dark. But not me: I can only see those glowing orbs so I shoot between thembam, bam, bam, bam, bamand briefly theres illumination, but only briefly, and I dont like what I see. So I pull my heart out of a dry well in the cellar, give it a puppy and tell it to fuck off home and wait for me there. Havent been back yet though, so I hope the puppys alright.

Off I go to work, building this Ark and raiding lost ones, and at one stage Im stuck on the wrong side of a crevasse and the tunnel is shaking and Im screaming, Throw me the whip so I can swing across! But Dr. Octopus is telling me, No, throw me your knowledge and then Ill throw you the whip. Hes saying theres no time, so I bundle my objects and stories and legacy and toss it across the void and I guess you know what happens next. I manage to get across later without the whip, then prize my knowledge from his cold, dead hands, only to lose it again to a boss villain. But thats alright, Ill get it back again. I think.

And I ask if feminism will find a place on the Ark, and then all the things that make up the fruits of that struggle (for equality?) are listed and included, except for the word itself. I argue for keeping it, and everybody is kind and they steel man my position and I feel good about all this support, that in the end all things are reducible to an essence, all things may be revealed by Occams razor. Stuff is a bit more complicated, a bit more nuanced though, when it comes to some issues around masculinity. I guess every man loves Occams razor until its time to shave his balls.

I sometimes fear I will be extradited to Wokestan and publicly executed. I still have friends and family there, and I hope theyre okay. And I would like to know if that puppy is alright. Maybe shes grown and had puppies of her own. Its been a long time since I started working on this transhumanist Ark. There are spaces for the Enlightenment, founding fathers, crypto wallets, VR goggles, breath work, meditation, leadership workshops, and micro-doses of DMT. It smells great and every surface is finished with evolutionary fitness. There is a security guard out front, but thats only to stop Jeffrey Epstein sneaking on board with his egg-shaped dick. We all know that bastard never died in prison so we have to stay vigilant, because there are kids on the Ark too and we need to keep them safe. If something happened to them, who would we practice our Vygotsky on?

Yeah, its all starting to make sense. Chaos and complexity. Institutions and decentralization. Generator functions. Perverse incentives. Bad and good faith discourse. Destruction or survival. Survival. Survival. I wonder, when that steel man inhabits my palatable, ambiguously non-white form, does it see survival in there? What does that survival look like? Is it some Bear Grylls shit, or is it a blonde girl living with cognitively diverse cavemen until she gets kicked out for getting too good with a sling shot? Certainly its a nightmare of fight or flight, my kind coming in the night with spears, or my kind eternally hyper-vigilant out on the savannah, hunted constantly by super predators and you never know where they are, and life is brutish and horrible and thats how our brains and social systems evolved, right?

The steel man leaves my body and I am myself again. I went somewhere while he was walking around in my skin, inhabiting my position. I went home. I flew over rivers and followed them like arteries to find my heart again and it was a shame the puppy didnt survive but I was home! The mangroves were breathing like a fat man into a microphone. I could never hear them before but they do have that name, the same name as lungs, those breathing roots. I know my old people must have heard them too, the same way to understand, not through a microscope but through language.

All the old girls are there at the beach going for mudshell and longshell and crab, but I cant stop because Im going for stingray with Dad there near the oyster reef, the body of that ancestral brolga hiding its egg from the narcissistic emu who stole her children. I miss my children. But Dads showing me the drag marks from the monster crocodile who lives there, and we have to go into that water where hes waiting for us. We dont mind. Were not fighting or flighting or anything like that.

We know that predator and where he is. We know the trick of how to pass him invisiblethe discipline of holding him in your awareness in that instant while also not thinking of him at all. Its a hell of a meditation, that one, and beats the shit out of TM. Because were related to our predators, and we always know where they are. A tiger shark comes and Dad turns him with his spear. I spear stingrays. Dad stirs them up and sends them crashing into my legs to make sure I know the lesson about the lie of fight or flight. If I jump or run or attack they will sting me. If I stand among them Ill be fine and theyll share their bodies for our meat. So I stand there and know that were more than what weve become. Were more than a story of survival. We were always more (us humans, I mean).

I spear way too many stingray, more than we could ever eat there. It doesnt matter. There is an abundance in this season and they are fat. That fat is what my brain is made of, and its how I evolved that brain. I cook the stingrays and thats my two hours work done to sustain our lives that day. The survival hours I guess youd call them. The rest of the day is for walking, meeting people, ritual and ceremony, arts and crafts, sex and love, feasting and sport, fighting and reconciling, governing and trading collectively. The leftover stingrays wont go to wasteit all goes into the land, feeding the plants and spirits of place that have evolved to depend on these things. I might take the livers out though, because I really like that liver. It makes my abs pop.

But the land moves and you must move with it. Altered states tend to shift in the same way and I find myself back in my fat domesticated body when the steel man is finished with it. Im losing the weight though, and feeling a bit happier. I have friends now who practice their kindness on me, no matter what kind of awful things I say, and Im just making so much sense now that people have started buying my book, which means I can afford a Keto diet and some weights and a punching bag. Sixteen hours is a lot of work, between the job and the gigs and the kids and the housework and the cooking and so on, but its worth it they say. Its better than primitive subsistence and getting raped and eaten by tigers all day, struggling for survival. Did you know a third of all caveman deaths were homicides? True, we checked the Neanderthal church records. Your ancestors were evil and stupid and unhappy. Forget them.

Its time to grow beyond this meat suit, this clumsy primate in clothes who stinks and shits and dies. Its time to outlive survival, time to upload consciousness and fly to the stars and be the demi-gods we all deserve to be, god dammit!

Thats what they tell me anyway. We all just have to keep working a little longer, extracting the last of the stuff. The tech bros say theyre too tired and sad to merely survive now, and that this world is probably all a simulation anyway. They want to embody the etymology of that weird verb, and live above. They say they will look down at the rest of us left behind in the biosphere like were squirrels or something. I wont be going. Somebody has to clean up.

I guess thats what the future is to me. Its a janitorial position, a thousand years of making our land livable again, and patiently bringing former settlers back under the Law of the land again. Its not quite survival, and its not quite deliverance, although there may be some banjos and bow hunting involved. Its survivance.

Survivance is a collaboration between the Solomon R. Guggenheim Museum and e-flux Architecture.

Tyson Yunkaporta is an academic, an arts critic, and a researcher who is a member of the Apalech Clan in far north Queensland. He carves traditional tools and weapons and also works as a senior lecturer in Indigenous Knowledges at Deakin University in Melbourne.

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Indian doctors protest herbal treatments being touted for COVID-19 – National Geographic

Posted: June 6, 2021 at 2:33 am

As India struggles with one of the worlds worst COVID-19 outbreaks, thousands of doctors across the nation fighting to save patients amid shortages of oxygen, medicine, and vaccines wore black armbands on June 1 to call for the arrest of India's most popular yoga televangelist. Baba Ramdev, founder of a traditional medicine empire, is peddling unproven herbal pills and yoga cures for COVID-19, while calling modern drugs stupid" and blaming the countrys hundreds of thousands of coronavirus deaths on modern medicine.

But far from being fringe, Ramdev has close ties to Indias Hindu nationalist government and has enjoyed the support of the health minister. Since the pandemic began last year, Prime Minister Narendra Modis government has been aggressively promoting Ayurvedaa traditional system of medicine with deep links to Hinduism that originated 5,000 years ago and is still widely practiced by hundreds of millions of Indians. Ayurveda uses plant-derived products, yoga, diet, and behavior changes to treat the mind and body, and is included in Indias official COVID-19 management protocol as a prevention and cure for the pandemic.

Recently, as vaccination has stalled in India due to drug shortages, the government began distributing a free, unproven formulation called AYUSH 64, an Ayurvedic pill made from four herbs that the government claims has "anti-inflammatory and immunomodulatory activities. (The pill shares its name with the acronym for the government ministry of traditional medicine, which also means long life.) Some ruling party-linked lawmakers and religious groups have even advocated drinking cow urine and smearing oneself with cow dung to safeguard against the virus.

But as a second wave of the coronavirus has claimed the lives of 335,000 Indians as of June 2, according to theNew York Times, alternative remedies that lack scientific evidence of efficacy are under fire from modern medicine doctors and even some prominent Ayurveda practitioners.

Ayurveda was [Indias] first attempt at science," says M. Shafi Kuchay, an endocrinologist at the Medanta hospital in Gurugram, a technology hub outside the Indian capital. "But today it is inefficient, he says, especially in the absence of credible studies."

Hemant Toshikhane, one of Indias leading professors of Ayurveda, was among many who used to believe the ancient remedies could guard against the deadly coronavirus pandemic.

Starting in March last year, the Parul Institute of Ayurved & Research, which Toshikhane runs, distributed traditional herbs for fever and digestive disorders and medicated nasal drops to faculty and students to ward off the virus. There were some COVID-19 infections recorded last year in Waghodia, in the western state of Gujarat, where the institute is located, but none among anyone who received the kits, according to Toshikhane.

A year later, a devastating second wave of the pandemic has swept through India, bringing the number of deaths to some 4,000 people nearly every day from mid-April through May. Toshikhane dutifully handed out the herbal kits again, but this time, most people got sick anyway, he says, so I stopped.

Ayurveda, which translates from Sanskrit as knowledge of life, is based on the principle that the body is composed of the same five elements that make up the universeair, fire, water, earth, and etherrepresented in the human body as doshas,or problems, explains Toshikhane. If the three main doshasVata, Pitta and Kaphaare not balanced, it leads to diseases. Rebalancing these doshas is done by modifying lifestyle and diet. The three mental doshasSattva, Rajas, and Tamasare treated with yoga and meditation. Ayurveda practitioners also treat disease with herb- and mineral-based medicines and surgery.

But there have never been conclusive studies on the efficacy of these treatments for chronic or infectious diseases. According to the National Center for Complementary and Integrative Health, part of the U.S. National Institutes of Health, aside from treating some pains and a few symptoms of type 2 diabetes, there is little scientific evidence on Ayurvedas value for other health issues. Many studies on Ayurvedas effectiveness are small, and few are published in peer-reviewed Western medical journals.

Even so, a large majority of Indians place faith in this ancient medical system. Nearly 80 percent used Ayurveda in 2018, up from 69 percent in 2015, according to a PricewaterhouseCoopers report on the resurgence of Ayurveda in India. The report predicts the countrys Ayurveda market will grow from $2.5 billion in 2015 to $8 billion in 2022.

Indias Hindu nationalist ruling party has long touted the healing powers of yoga and Ayurveda and in 2014, soon after taking office, Prime Minister Modi upgraded a department dedicated to the study of traditional medicine to the Ministry of Ayurveda, Yoga, Naturopathy, Unani, Siddha, Sowa-Rigpa and Homoeopathy, abbreviated as AYUSH. These therapies got an additional boost when the World Health Organization greenlit trials for alternative COVID-19 therapies last September. India answered the call with more than 100 different studies examining the efficacy of various traditional medicines, including everything from therapeutic yoga positions to Kadha, a type of herbal tea consumed to fight coughs and colds.

But Rajan Sharma, an orthopedic surgeon and former president of the Indian Medical Association, says the studies lack credibility because of very small sample sizes. The pilot study on AYUSH 64, for example, was led by mostly government researchers and included only 140 people. The researchers concluded the herbal pill could treat COVID-19 because another study in the Journal of Ayurveda and Integrative Medicine found it effective for influenza-like respiratory illnesses. Even Ayurveda experts are now calling this into question.

A letter in the same journal noted the AYUSH 64/influenza trial studied a mix of modern and Ayurvedic medicines, making the claims of efficacy against flu-like illness scientifically untenable since it is not possible to identify the drug that actually cured or brought relief to patients.

Doctors have warned that unscientific practices, like smearing cow dung on ones body, could be dangerous, leading to other infections, such as mucormycosis, known as black fungus. (Read about a rare black fungus infecting Indias COVID-19 patients.)

In 2008, the U.S. Food and Drug Administration cautioned Americans against using Ayurvedic products, because one-fifth were contaminated with lead, mercury, or arsenic. In 2017, the FDA had issued a safety alert against specific Ayurvedic medicines linked to two cases of lead poisoning in Michigan.

Hepatologists have long warned of the harmful effects of Ayurvedic and other traditional medicines on the liver. In a 2019 study, Jawad Ahmad, a professor of medicine specializing in liver diseases at Mount Sinai Hospital in New York,warned of rising liver injury and failure from increased use of herbal supplements, especially in Asia.

Ahmad notes peopleturn to herbal remedies because there are few options, and they want to "maximize their chances of survival," he says. "Thats just human nature."

This is exactly what happened in India. As COVID-19 cases surged, along with a shortage of hospital beds, drugs, and oxygen, so have Internet searches by those desperate for herbal remedies that might help.

Sharma, the former head of the Indian Medical Association, sees hypocrisy in pushing Ayurvedic pills and potions. Last year, when Shripad Naik, the minister of alternative medicines, tested positive for COVID-19, he opted for modern medical treatment at a private hospital.

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ModiHealth Acquires More Active: Customers Will Have the Tools to Get and Stay Physically, Emotionally, Spiritually, and Mentally Fit at Their Virtual…

Posted: June 6, 2021 at 2:33 am

Club Industry was not involved in the creation of this content.

The ModiHealth whole-person virtual care platform will add an incredibly robust streaming service and app powered by new health technology with the acquisition of More Active, as they also welcome Founder Don Hoskyns to the ModiHealth team as President of Digital Wellbeing

LOS ANGELES, California (June 2, 2021): ModiHealths acquisition of More Active provides customers with a full-body care experience at the top of its class. ModiHealth, a one-stop-shop for every aspect of whole-person health and wellness, provides a vast integrative range of holistic care options under one virtual roof. Adding the More Active technology to its platform and health app provides customers with a powerful guide to being fit; mind, body, heart and spirit. With 59 percent of Americans not planning to renew their gym memberships after COVID, ModiHealth customers will now have premier at-home streaming workouts, fitness plans, nutrition plans, health tracking, wellness tools and support available in the palm of their hands.

Bringing More Active s technology and content to ModiHealth furthers our goal of providing people with the tools to reach their optimal health, says ModiHealth co-founder and CEO Dr. Rachel Dew. We are closely aligned with the More Active team and are lucky to have Don Hoskyns on board as ModiHealths President of Digital Wellbeing.

More Active was founded by Don Hoskyns, whose interest and passion for health and diet started in his high school days when he was a wrestler and eventually led him to develop the successful More Active desktop and app technology.

I started More Active in 2013 to build a digital fitness platform, says Don Hoskyns, More Active Founder. Its been exciting to see how it has transitioned into a whole-person health and wellbeing platform.

More Active will bring the following to the ModiHealth streaming service and health app:

"My Plan Personalized and Individualized User Wellness Plan

Platform Customizes to User Goals & Needs

Online Workout Plans, Nutrition, Education and More

Health Risk Assessment Testing (Evaluation & Reporting)

Goal Oriented Fitness Challenges (per Individual and Group)

Personal Health Record and data tracking for progress

3D Weight Loss and body transformation (Before & After Morphing App.)

Wearable integration: FitBit, Garmin, MyZone (Others coming soon)

Corporate Wellness tools

Disease Management

Blood Panel and Genetic / DNA testing / Integration

*Daily health guidance and inspirations

*Thousands of articles & videos to support health

Streamline and up-level every aspect of your journey to health and wellness with ModiHealth on one convenient website at Modiht.com. From live virtual care to a robust wellness streaming service and health memberships, ModiHealth helps customers get and stay healthy!

About ModiHealth:

Founded in 2016 by double-board certified Doctor of Natural and Integrative Medicine Dr. Rachel Dew and Neurologist/Engineer Randall Wright, MD., ModiHealth is the only integrative whole-person virtual care platform on the market offering access to every type of practitioner, including holistic, natural, and functional doctors, along with nutritionists, mental health practitioners, health and life coaches, personal trainers, and more. ModiHealth is the only online platform that offers a whole-person integrative care approach through real-time virtual care consultations, in addition to health and wellness programs/services. The extensive ModiHealth platform includes providers, practitioners, and wellness professionals in traditional medical care and integrative, holistic, functional, alternative, and mental health care. Plus, find nutrition experts, wellness coaches, fitness trainers, and more! Users can expand their wellness and well-being through on-demand support from a health streaming service and specialized programs. Discover the future of optimized virtual health and wellness at Modiht.com. ModiHealth: Your path to better health starts here!

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