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Increasing Prevalence of Diabetes Expected to Enhance the Growth of the Global Antidiabetics Market Exclusive Report [150 Pages] by Research Dive -…

Posted: December 27, 2020 at 5:56 pm

TipRanks

With 2020 winding down, theres a growing belief that 2021 is going to be a growth year for the stock markets. The US elections have returned a divided government, one unlikely to have the broad majorities or the broad support needed to enact wide-ranging reform legislation from either the right or left, and that bodes well for the economy generally.The COVID vaccines are entering distribution, and while new anti-virus lockdowns are also getting set in place, theres a feeling that the end of the pandemic may be near. According to the analyst community, a few names reflect serious growth plays. These are stocks that have already notched impressive gains year-to-date, and are poised to see the growth keep on coming even after 2020 wraps up.Bearing this in mind, we usedTipRanks databaseto scan the Street for tickers that fall into this category. Locking in on three in particular, the analysts believe that each name, which also happen to boast a Strong Buy consensus rating, can keep the rally alive in 2021.SunOpta (STKL)The first stock on this growth list is a health snack company, SunOpta. The companys line of products includes plant-based beverages, fruit-based snacks, broth and stocks, teas, and sunflower and roasted snacks. The company markets through private label and co-manufacturing distribution, as well as through food service institutions.SunOpta boasts a market cap of $962 million, after a year of stunning share price growth. The stock is up an impressive 328% this year, far outpacing the general markets. The companys Q3 revenues came in at $314.9 million, a 6.4% year-over-year gain. EPS, at a net loss of 1 cent, was better than the 2-cent loss expected and far better than the 11-cent loss reported in the year-ago quarter.The companys solid performance has attracted the attention of Craig-Hallum analyst Alex Fuhrman. The analyst rates STKL a Buy along with a $15 price target. This figure implies a one-year upside of 40% from current levels. (To watch Fuhrmans track record, click here)Backing his stance, Fuhrman wrote, We believe the companys focus on high value plant-based foods and beverages should command a premium valuation with opportunities for upside to estimates as the economy recovers from COVID.In large part, Fuhrmans optimism is based on SunOptas niche. The analyst noted, We expect plant-based food stocks to command a premium valuation to other food companies for the foreseeable future given faster growth trends and compelling environmental benefits. At just $4.5B in sales today, plant-based products are less than 1% of the $695B grocery market, but it is easy to envision it representing a double-digit share of grocery sales over time. Wall Street doesnt always come together in unanimity, but in this case, it does. SunOptas Strong Buy analyst consensus rating is unanimous, based on 3 Buy reviews. The stock is selling for $10.70, and with an average price target of $15, SunOpta has a forward growth potential of 40%. (See STKL stock analysis on TipRanks)Green Brick Partners (GRBK)One bright spot in the economy this past year has been the home construction industry. As people moved out of the cities to avoid COVID, they headed for the suburbs and exurbs and that boosted the demand for single-family homes. Green Brick is a land development and home acquisition company, based in Texas. The company invests in real estate, primarily land, and then provides plots and construction financing for the development projects.The spread of the suburbs not just in this COVID year, but as a general trend, has been good to Green Brick. The companys Q3 revenue was $275.8 million, the best in more than year, beating the forecast by 20% and growing 31% year-over-year. EPS was also strong; the Q3 value, 68 cents, was 54% above expectations, and more than double the year-ago value.Green Bricks share price has been rising along with the companys financial outlook. For the year, GRBK has gained 111%.In his coverage of this stock, JMP analyst Aaron Hecht noted, [We] expect GRBK to capitalize on the trend of apartment renters shifting to single-family homes for safety and changing dynamics brought on by more workers telecommuting. The most important cohort shift within the buyer pool is millennials who have come off the sidelines to buy homes, a trend which we believe has multiple years of runway. The millennial demand trend is magnified in GRBKs case given its outsized exposure to markets, such as Texas & Atlanta, which are the net beneficiaries of migration out of high-priced coastal geographies.To this end, Hecht rates GRBK an Outperform (i.e. Buy), and his price target of $30 implies an upside of ~23% for the next 12 months. (To watch Hechts track record, click here)While not unanimous, the Strong Buy consensus rating on Green Brick is decisive, with a 3 to 1 breakdown of Buys versus Hold. The average price target of $27.5 gives a 12.5% upside potential from the current share price of $24.45. (See GRBK stock analysis on TipRanks)Brightcove, Inc. (BCOV)Shifting gears to the software industry, we come to Brightcove, a Boston-based software company. Brightcove offers a range of video platform products, including cloud-based hosting and social and interactive add-ons. The company is a leader in the delivery and monetization of cloud-based online video solutions.The strength of such a business model, during these pandemic days with their massive shift of white-collar workers toward remote offices, telecommuting, and video conferencing, is obvious. Brightcoves earnings hit 11 cents per share in Q3, nearly double the year-ago quarter. At the top line, revenues have been stable, holding between $46 million and $48 million per quarter in 2020, with no discernable COVID impact.Shares in Brightcove have been going up in steps all year, after a minor blip last winter. The pace has accelerated since the end of July, after the Q2 results were released, and the stock is now up 103% for 2020. The general macro headwinds are turning into video niche tailwinds, as noted by Northland Capital analyst Michael Latimore. We believe a market tailwind, BCOV's leading tech platform, and strong sales execution are driving strong bookings. We believe the salesforce is at full productivity. BCOV will add more channel managers this year. Management is focused on process improvements to achieve consistency in revenue retention rates, the 5-star analyst noted.Latimore rates the stock as Outperform (i.e. Buy), and his $24 price target indicates confidence in a 36% upside for the year ahead. (To watch Latimores track record, click here)Over the past 3 months, two other analysts have thrown the hat in with a view on the video tech company. The two additional Buy ratings provide Brightcove with a Strong Buy consensus rating. With an average price target of $20.17, investors stand to take home 14% gain, should the target be met over the next months. (See BCOV stock analysis on TipRanks)To find good ideas for growth stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights.Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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COVID-19 Impact On Individuals With Diabetes – WFMD

Posted: December 27, 2020 at 5:56 pm

December 22, 2020 - 11:22 am

Approximately 34% of Maryland adults are believed to be prediabetic

Frederick, MD (KB) Governor Larry Hogan recently announced a $94 million-dollar investment in the treatment and prevention of diabetes amidst the COVID-19 pandemic.

The Maryland Department of Healths Kristi Pier said the percentage of Marylanders with diabetes is slightly higher than the national prevalence.

About 11.1% of Maryland adults have diabetes, so over 10 in 100 have diabetes in Maryland, she explained. Which is a little bit higher than the national prevalence, which is about 10.5%.

Pier said there is a risk for individuals with diabetes who contract the coronavirus.

Diabetes there is a big concern during the pandemic due to the high prevalence of diabetes in the state, she said. As well as the increased risk for serious illness if someone with diabetes contracts COVID-19.

Some early warning signs of diabetes, according to Pier, are feeling hungry or thirsty despite eating, and fatigue.

Individuals who think they may be prediabetic can take a risk assessment online at the either the CDC or American Diabetes Association website. Pier listed the individuals who are most at risk for the disease.

Those that are most at risk are those people who have prediabetes, those adults who are also overweight, who are 45 years and older, or maybe have a parent, a brother, or sister who have Type 2 diabetes.

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Comparison of Coronary Heart Disease and Stroke in Association with Di | DMSO – Dove Medical Press

Posted: December 27, 2020 at 5:56 pm

Guang-Ran Yang,1 Dongmei Li,2 Lin Li3

1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, Peoples Republic of China; 2Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA; 3Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing 100730, Peoples Republic of China

Correspondence: Guang-Ran Yang Email gr.yang@ccmu.edu.cn

Objective: Diabetic retinopathy (DR) was reported to have higher prevalence of coronary heart disease (CHD) and stroke compared with people without DR. However, whether DR had similar effects on CHD and stroke in US adults with diabetes was not well known. This study was to compare the association between DR, CHD and stroke in US adults with diabetes using the 2015 Behavioral Risk Factor Surveillance System (BRFSS).Methods: Respondents with diabetes aged over 18 years and undergone a fundus examination over the past 2 years were included in this study. DR, CHD and stroke were self-reported. A weighted hierarchical logistic regression was used to examine the association of DR with CHD and stroke.Results: A total of 21,049 respondents with diabetes aged over 18 years having undergone a fundus examination over the past 2 years were included in the analysis. There were 4690 people reported having CHD, accounting for the weighted prevalence 22.1%. The weighted prevalence of stroke was 9.6%. There was 28.3% of CHD people who had DR which was higher than that in people without CHD. Differences in weighted frequency distributions of gender, age category (over 45 years or not), current smoking, hypercholesterolemia, hypertension and insulin treatment were significantly different between the CHD and without CHD groups (p< 0.001). Similar results were found in people with stroke. Logistic analysis showed that DR was related to CHD and stroke (crude OR =1.876, 2.263, respectively, p all < 0.001). After adjusting other variables, these associations persisted (Adjusted OR=1.632 (95% CI=1.625 1.639), 1.846 (95% CI=1.836 1.856), respectively, p all< 0.001).Conclusion: The BRFSS 2015 data indicated that DR was not only associated with CHD but also associated with stroke in US adults with diabetes, independently of other risk factor. DR might be more strongly associated with stroke than with CHD.

Keywords: diabetes, diabetic retinopathy, coronary heart disease, stroke, risk factor

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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How 2020 Changed Diabetes and Primary Care – Medscape

Posted: December 27, 2020 at 5:56 pm

This transcript has been edited for clarity.

Hello, my name is Kamlesh Khunti, Im professor of primary care diabetes and vascular medicine at the University of Leicester.

We are nearly at the end of the year and what a year it's been. The COVID-19 pandemic has had a major impact globally, with 71 million people being infected worldwide, and 1.6 million deaths due to COVID as of mid-December 2020. Little did we know in March that we would expand our vocabulary, with new words and phrases that would be used in daily conversations. These include social distancing, furlough scheme, R reproduction number, social isolation, quarantine, lockdown, and long COVID, are some of them.

Little did we envisage that wearing masks would become mandatory, or that working from home would become the norm for many who would become experts at MS Teams and Zoom virtual meetings, and learn even to change our virtual backgrounds.

Practice Changes

During the COVID-19 pandemic attention has been diverted away from primary cares key roles in early detection of disease and management of long-term conditions. Clinical practice has changed beyond recognition, with the majority of consultations being by telephone or virtually.

Our patients have been very understanding and have embraced the new ways of working.

Some primary care practices have been innovative and seen patients in the carpark to reduce exposure by having the consultations outside.

Unfortunately, this is not ideal for people with chronic long-term conditions, particularly cardiometabolic conditions. Although telehealth reduces patients direct exposures to infection, it cannot entirely replace face-to-face contacts. Physical examinations are still needed to make certain diagnoses and to enhance the human connections between patients and clinicians.

Certain conditions, such as diabetes, cardiovascular disease, hypertension, chronic kidney disease, and chronic obstructive pulmonary disease have been shown to be associated with the increased risk of infection, hospitalisation, and mortality.

However, there have been excess deaths due to also the disruption of services because of the pandemic. Unfortunately, delays in diagnosis and suboptimal management of people with long-term conditions will cause rises in non-COVID mortality going forward as well.

Global surveys have shown that diabetes was the condition most reported impacted by the reduction in healthcare resources due to COVID-19, followed by chronic obstructive pulmonary disease, hypertension, heart disease, asthma, cancer, and depression.

Additionally, the two most common co-occuring chronic conditions for which care was impacted by COVID-19 were diabetes and hypertension.

A lack of access to routine health care is a leading cause of morbidity and mortality after disasters, and we've seen this in other disasters. So things such as stroke, acute myocardial infarctions, and diabetes complications are all shown to increase after the immediate threat has been dissipated.

However, there is now some good news on the horizon, with the prospect of a COVID vaccine being our main hope of coming out of this dreaded pandemic.

2021

So what should we be planning for the new year?

Well, the priority will be to vaccinate the most vulnerable, including the elderly and those with chronic conditions. Psychological stress has also increased during the pandemic and many people with chronic long-term conditions such as diabetes, and cardiovascular disease have been shielding, and have been unable to continue with routine lifestyle interventions such as exercise.

All these factors and the added burden of mental health will lead to worse risk factor control.

We therefore need to resume normal services and start arranging routine bloods and review clinics for our patients with chronic conditions.

We need to ensure we improve risk factor control for our patients with chronic cardiometabolic conditions, including blood pressure, HbA1c, and lipid control.

We will also have a number of patients who have been affected with COVID, and we will need to monitor these people very closely for consequences of long COVID.

It is too early to predict what the 'new normal' will look like. We must learn the important lessons from COVID-19 and previous pandemics to avoid the suboptimal management of long-term conditions contributing to the avoidable excess mortality in the medium-term.

Practitioners will need to consider ways of proactively identifying these patients with long-term conditions, who are most at risk of suboptimal management, to ensure that the necessary care is maintained urgently after we come out of COVID.

In summary, people with cardiometabolic conditions have been impacted significantly during the pandemic, and now we need to plan to get back to normal services and ensure we reduce the risk of major indirect consequences of COVID in our patients with long-term conditions.

On that note, I wish you a happy, safe, and peaceful festive break. Thank you.

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Lisa La on the Design of a Study Evaluating Diabetes in Patients with Multiple Myeloma – Cancer Network

Posted: December 27, 2020 at 5:56 pm

The director of clinical research in the Center for Cancer Care at White Plains Hospital explained the design of the study which evaluated diabetic versus nondiabetic patients enrolled in the CONNECT Multiple Myeloma Registry.

A descriptive analysis of the CONNECT Multiple Myeloma Registry, presented at the 2020 ASH Annual Meeting & Exposition, aimed to evaluate differences in baseline characteristics, treatment patterns, and survival outcomes in diabetic versus nondiabetic patients enrolled in the registry.

In an interview with CancerNetwork, Lisa La, director of clinical research in the Center for Cancer Care at White Plains Hospital, explained the design of the study.

Transcription:

Sure, so the Celgene, its actually a Celgene observational study. It's a large multicenter prospective observational study, primarily enrolling newly diagnosed multiple myeloma patients. So, the sample size that they've enrolled from 2009 to 2016, was about 3011 newly diagnosed myeloma patients across 250 sites. Those sites are community, academic, and government sites across the entire US. And it's pretty accurate in terms of not focusing on certain regions of the US, but across all of the entire so I would say it's pretty representative of the general population. So, patients that were eligible, just as long as you were 18 years and older and had some sort of diagnosis of myeloma, and less than 2 months before you enrolled, so they are they're just being pretty much followed up for treatment and outcomes.

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Study clarifies the impact of getting old on hematopoietic stem cells – Microbioz India

Posted: December 26, 2020 at 6:55 am

By shifting mouse elderly hematopoietic stem cells (aged HSCs) to the environment of young mice (bone marrow niche), it was shown that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. On the other hand, the function of elderly HSCs failed to recover in the young bone marrow niche. The epigenome (DNA methylation) of aged HSCs didnt change significantly even in the young bone marrow niche, and DNA methylation profiles were found to be a better index than the gene expression pattern of aged HSCs.

A research group headed by Professor Atsushi Iwama in the Division of Stem Cell and Molecular Medicine, The Institute of Medical Science, The University of Tokyo (IMSUT) declared these world-first Outcomes and was published in the Journal of Experimental Medicine (online) on November 24th.

The results will contribute to the development of treatments for age-related blood diseases.

Professor Atsushi Iwama, Lead Scientist, IMSUT

The research group investigated whether rejuvenating aged HSCs in a young bone marrow market environment would rejuvenate.

Tens of thousands of elderly hematopoietic stem/progenitor cells gathered from 20-month-old mice were transplanted into 8-week-old young mice without pretreatment like irradiation. After two months of follow-up, they collected bone marrow cells and performed flow cytometric analysis.

The research team also transplanted 10-week-old young mouse HSCs for comparison. In addition, engrafted aged HSCs were fractionated and RNA sequence analysis and DNA methylation analysis were conducted.

They discovered that engrafted elderly HSCs were less capable of producing hematopoietic cells compared to younger HSCs. They also showed that differentiation of aged HSCs into multipotent progenitor cells was persistently impaired even in the young bone marrow market, and that the direction of differentiation was biased. It was found that the transfer of aged HSCs into the young bone marrow market does not enhance their stem cell function.

A more detailed analysis may reveal mechanisms that irreversibly affect aged HSC functionAging studies focusing on HSCs have been chased in mice with a bone marrow transfer model. However, the effect of aging on HSCs remains to be clarified.

Professor Iwama says as follows. This analysis has a substantial impact because it clarified the effect of aging on HSCs. Our results are expected to contribute to further elucidation of the mechanism of aging in HSCs and comprehension of the pathogenic mechanism of age-related blood disorders.

Source:

Journal reference:

Kuribayashi, W.,et al.(2020) Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche.Journal of Experimental Medicine.doi.org/10.1084/jem.20192283.

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2020 in Scientists Own Words – The Scientist

Posted: December 26, 2020 at 6:53 am

We can slow it down by canceling all these events, which we completely should do. But its still going to spread to most places.

Maciej Boni, a biologist at Penn State University, speaking to The Scientistabout how the high number of undetected cases makes it difficult to track viral spread based on confirmed infections (March 12)

Abdul Mannan Baig, a researcher at Aga Khan University in Pakistan, speaking to The Scientistabout indications that SARS-CoV-2 can target the nervous system (March 24)

Kishana Taylor, a postdoc in microbiology and molecular genetics at the University of California, Davis, speaking to The Scientistabout pandemic-related hiring freezes in academia (March 26)

Kathleen Millen, a neuroscientist at Seattle Childrens Hospital Research Institute, in an email to The Scientistabout how pandemic-related lab shutdowns affected the scientific community (March 27)

A cryogenic electron microscope-based visualization of SARS-CoV-2 spike protein is helping researchers understand precise molecular interactions with antibodies.

VISUALIZATION BY RUBEN DIAZ, BASED ON WORK BY DAVID VEESLER, UNIVERSITY OF WASHINGTON

Anthony Fauci, director of the US National Institute of Allergy and Infectious Disease, speaking with CNNs Sanjay Guptaabout the effects of the COVID-19 pandemic on the psyches of his daughters and other Americans (April 1)

Peter Daszak, president of the nonprofit EcoHealth Alliance, talking to 60 Minutes about the ongoing politicization of science with regard to the COVID-19 pandemic (May 10)

Erica Ollmann Saphire, an immunologist at the La Jolla Institute for Immunology, speaking to The Scientistabout the promise of antibody candidates that could prevent SARS-CoV-2 from entering cells (June 2)

Jillian Carmichael, a postdoc in virologist Benhur Lees lab at Mount Sinais Icahn School of Medicine, speaking with The Scientistabout missing out on research during the pandemic due to the closure of daycares and schools (June 25)

Nelly Yatich, epidemiologist in Nairobi, Kenya, discussing with The Scientist the challenges of determining the basic reproductive number, R0, which describes the initial spread of an infection in a completely susceptible population (July 13)

Hannah Davis, an artist living in Brooklyn, speaking to The Scientist about memory loss, sporadic bursts of blurred vision, a racing heart, difficulties breathing, insomnia, and various aches and pains that she experienced for months after testing positive for COVID-19 (July 17)

Ravinder Sehgal holds one of the birds he studied at a site in southwest Cameroon.

COURTESY OF RAVINDER SEHGAL

A. David Paltiel of Yale School of Public Health speaking to UPIabout his paper that indicated that masks, social distancing, and testing college students every two days could limit the spread of SARS-CoV-2 on campuses this fall (July 31)

Ravinder Sehgal, a biologist at San Francisco State University, speaking to The Scientistabout how a pandemic-related university travel ban limited his field research in infectious diseases (August 20)

Miriam Merad, who directs the Precision Medicine Institute at Mount Sinai, speaking to The Scientist about the rapid pace of COVID-19-related research this year (September 16)

Rick Bright (center) with National Institute of Allergy and Infectious Diseases Director Anthony Fauci (left) and Marilyn Serafini, former president and co-CEO of the Alliance for Health Reform

Patricia Garca, a Solidarity Trial investigator and the former health minister of Peru, speaking with The Scientistin the wake of the Surgisphere scandal (October 1)

An amended whistleblower complaint filed by attorneys representing Rick Bright, an immunologist who resigned from his post at the National Institutes of Health on October 6

Albert Bourla, chairman and chief executive of Pfizer, speaking to CNBC after the firm announced preliminary results from a Phase 3 trial of its COVID-19 vaccine, developed in collaboration with BioNTech, that suggest it is 90 percent effective in preventing the disease (November 9)

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Global Adaptive Optics (Wavefront Sensors, Deformable Mirrors and Control System) Markets Report 2020-2026 – ResearchAndMarkets.com – Business Wire

Posted: December 26, 2020 at 6:53 am

DUBLIN--(BUSINESS WIRE)--The "Global Adaptive Optics Market Analysis and Forecast, 2020 - 2026" report has been added to ResearchAndMarkets.com's offering.

The Global Adaptive Optics Market size is expected to reach $433.2 Million by 2026, rising at a market growth of 13.5% CAGR during the forecast period.

Adaptive Optics (AO) is quickly picking up demand as a possibility for enhancing the performance of optical systems. Optical instruments experience errors while measuring and imaging because of distortions found in light waves. Adaptive optics assists with nullifying these mistakes, in this way, improving the performance of the optical instruments. The increasing prevalence of retinal degeneration diseases is anticipated to impel the development of the market. Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) are the most well-known retinal degenerative diseases across the world.

High-resolution phenotyping with adaptive optics imaging alongside molecular genetics analyses is anticipated to improve the clinical imaging of AMD and RP in the beginning phases. The increasing use of Adaptive optics for clinical application and research is anticipated to fuel the overall market development. Adaptive optics alongside Optical Coherence Tomography (OCT) is slowly penetrating the market because of its viability in giving enhanced and high-speed imaging. Advanced deformable mirrors are being created to exactly control the incident wavefront by reshaping a reflecting membrane with the assistance of precise magnetic actuators.

The improvement of these deformable mirrors is anticipated to decrease the size, cost, and complexity of AO-OCT gadgets, accordingly, making adaptive optics broadly adopted for different clinical applications. In this manner, the development of cutting edge Adaptive optics devices alongside increasing endeavors of vision researchers, ophthalmologists, and entrepreneurs in its development and research, is anticipated to drive the market.

The increasing prevalence of various retinal infections, for example, retinal degenerations, inherited color vision deficiencies, albinism, glaucoma, and numerous other eye diseases is anticipated to drive the market. Furthermore, the increasing awareness of Adaptive Optics (AO) and its efficient utilization in research for retinal imaging is also anticipated to contribute towards market development.

The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Teledyne Technologies, Inc., Northrop Grumman Corporation, Adaptica S.r.l (He Vision Group), Thorlabs, Inc., Iris AO, Inc., Active Optical Systems Ltd., Flexible Optical B.V., Imagine Optic SA, Boston Micromachines Corporation and Phasics Corporation.

Key Topics Covered:

Chapter 1. Market Scope & Methodology

1.1 Market Definition

1.2 Objectives

1.3 Market Scope

1.4 Segmentation

1.5 Methodology for the research

Chapter 2. Market Overview

2.1 Introduction

2.1.1 Overview

2.1.2 Market Composition

2.2 Key Factors Impacting the Market

2.2.1 Market Drivers

2.2.2 Market Restraints

Chapter 3. Recent Developments in Global Adaptive Optics Market

Chapter 4. Global Adaptive Optics Market by Component

4.1 Global Wavefront Sensors Market by Region

4.2 Global Deformable Mirrors (Wavefront Correctors) Market by Region

4.3 Global Control System Market by Region

Chapter 5. Global Adaptive Optics Market by Application

5.1 Global Microscopy Market by Region

5.2 Global Ophthalmology Market by Region

5.3 Global Laser Application Market by Region

5.4 Global Other Applications Market by Region

Chapter 6. Global Adaptive Optics Market by Region

Chapter 7. Company Profiles

For more information about this report visit https://www.researchandmarkets.com/r/tbrs9o

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Valo Announces Exclusive Partnership with G3 the World’s Largest and Detailed Cardio-Metabolic Datasets – BioSpace

Posted: December 26, 2020 at 6:53 am

BOSTON, Dec. 22, 2020 /PRNewswire/ --Valo Health, LLC (Valo), has announced an exclusive drug discovery and development partnership with Global Genomics Group, (G3), giving Valo access to the largest and most-detailed cardio-metabolic dataset in the world. Since the inception of the partnership, Valo has identified subpopulations across the cardiometabolic spectrum that have not been resolved before now, and are leading to the discovery of underlying genetics, biomarkers, and new disease-modifying targets. Using its Opal Computational Platform, Valo has been able to identify six validated targets and approximately 20 early potential targets and disease subpopulations.

"This partnership fits perfectly into Valo's strategy to utilize deep clinical human disease data with the powerful platform we have built to redefine diseases and identify sub diseases and patient populations," said Brett Blackman, Valo's Chief Innovation Officer."At the heart of Valo is our strong belief that human-centric data, coupled with leading-edge computation, will transform and accelerate how drugs are discovered and developed."

Valo is using their machine learning algorithms and G3's high dimensional best-in-class patient data to resolve never before patient-disease subpopulations that guide their discovery of novel targets. This provides confidence in identifying the right patient population to develop a disease-modifying medicine at the start of a discovery program. Valo's Opal Computational Platform takes the novel target and rapidly creates clinical candidates to test in those populations, dramatically cutting time and cost while increasing the probability of a drug's success.

"Working with Valo we are poised to transform and de-risk drug development, based on genetic validation of drug targets and on the use of biomarkers to conduct precision clinical trials in the right patient populations," said Szilard Voros, CEO, and co-founder of Global Genomics Group (G3). "For years, everyone has been talking about genetics -and biomarker-driven clinical trials - with Valo, we are actually now doing it."

G3's proprietary data comes from the Genetic Loci and the Burden of Atherosclerotic Lesions (GLOBAL) clinical study (NCT01738828) and represents one of the largest such disease-centric data sets in the world, designed and executed by G3. The GLOBAL study generated extremely large and complex data sets including whole genome sequencing and phenotypic associations to identify and link biological target (genotype) - phenotype - biomarker(s) as well as 3 billion data points from each of the nearly 8,000 patients with cardiovascular disease and from control subjects. G3 has over 320K blood samples and 8,000 advanced CT imaging datasets for evaluation, all standardized, normalized, and curated.

About ValoValo Health, LLC (Valo)is a technology company that is using human-centric data and machine learning-anchored computation to transform and accelerate the drug discovery and development process. By integrating data across the drug development lifecycle, the discovery and development of life-changing treatments can be accelerated, with the potential to reduce cost, time, and failure rate. The company's Opal Computational Platform, a fully-integrated, componentized, end-to-end drug development platform, offers a unique approach to therapeutic development, that enables Valo to advance a robust pipeline of candidates across cardiovascular disease, oncology, and neurodegeneration. Headquartered in Boston, MA, Valo has offices in San Francisco, CA, Princeton, NJ, and Branford, CT. To learn more, visit http://www.valohealth.com

About G3 TherapeuticsG3 Therapeutics is a global leader in the application of unbiased biological big data in transforming the drug discovery and drug development process. G3 Therapeutics has assembled a revelatory platform that utilizes deep phenotyping, deep molecular profiling and deep learning for the discovery, genetic validation and development of novel drug targets. G3 Therapeutics' foundational biological big data platform has been built on the GLOBAL Clinical Study (NCT01738828), enrolling over 7,500 individuals from around the world. G3 Therapeutics' deep molecular profiling approach includes whole genome sequencing, as well as the measurement of all other relevant "omics" measurements including DNA methylation, RNA sequencing, proteomics, metabolomics, and lipidomics. G3 Therapeutics has already discovered and patented relevant biomarkers and is starting the development of several novel drugs based on its proprietary platform and discoveries.

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Ukraine develops test for simultaneous detection of COVID-19, two flu types – Ukrinform. Ukraine and world news

Posted: December 26, 2020 at 6:53 am

Researchers at the Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine have developed a combined PCR test capable of simultaneous detection of SARS-CoV-2 and influenza A and B viruses.

"New PCR tests were checked on patients samples provided by the Center for Public Health. We hope that the Ministry of Health will be interested in the combined PCR test," said Director of IMBG, Academician Mykhailo Tukalo, the Institute of Molecular Biology and Genetics posted on Facebook.

The Institute notes that the test run time is about 6 hours.

Given the similarity of flu and coronavirus symptoms, such a PCR test is especially relevant now when Ukraine is expecting a seasonal flu epidemic.

Also, according to the Institute, scientists complete the development of a test that will detect simultaneously five viruses in a human body, in particular, rhinovirus and measles.

As reported, in January 2020, the Institute of Molecular Biology and Genetics developed and certified coronavirus test systems commissioned by the National Security and Defense Council.

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Ukraine develops test for simultaneous detection of COVID-19, two flu types - Ukrinform. Ukraine and world news

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