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Stem Cell Transplant Reduces Relapses and Disability in RRMS… – Multiple Sclerosis News Today

Posted: December 16, 2020 at 10:58 am

Autologous hematopoietic stem cell transplant (AHSCT) induces a reduction in relapse rate and physical disability in patients with relapsing-remitting multiple sclerosis (RRMS) who respond inadequately to other treatments, a small study suggests.

The study, Selective cognitive dysfunction and physical disability improvement after autologous hematopoietic stem cell transplantation in highly active multiple sclerosis, was published in the journal Nature Scientific Reports.

AHSCT is an experimental approach to treat multiple sclerosis (MS) that is meant to rebuild a patients immune system in order to stop attacks on the brain and spinal cord.

The procedure begins with collecting a patients own (meaning autologous) healthy hematopoietic stem cells immature cells that can develop into all types of blood cells from the bone marrow. These cells are put back into the patient after a fairly non-aggressive combination of chemotherapy is given to kill the patients immune cells.

A team of researchers at the Vilnius University, in Lithuania, evaluated the effectiveness and safety of the AHSCT procedure in 24 patients (18 female, mean age 37.8 years) with highly active RRMS (mean disease duration of 8.6 years) who failed to respond to conventional therapies.

The aim of the study was to assess cognitive dysfunction and physical disability after AHSCT, to explore the potential factors influencing disability regression after the transplant, and to estimate the safety of low-dose immunosuppressive therapy in highly active relapsing MS patients.

Researchers assessed participants disability and cognition through changes in several functional measures, including the expanded disability status scale (EDSS) and the Brief International Cognitive Assessment for MS, which includes three cognitive domains measured by the symbol digit modalities test, brief visuospatial memory test revised, and California verbal learning test second edition.

Of the 24 patients, 13 (54.2%) completed a 24-month follow-up and were included in the efficacy analysis of AHSCT. From those, two (15.4%) had one relapse during the first year after AHSCT and three patients (23.1%) had one relapse during the second year after AHSCT.

The annualized relapse rate (ARR) was 2.7 one year before AHSCT and 1.9 at two years before AHSCT. After the AHSCT procedure, ARR dropped to 0.2 in the first year and to 0.3 in the second year. This represented an 89% reduction in ARR, when comparing the values at two years after AHSCT with those at two years before AHSCT.

The researchers also noted a reduction in disability progression (as measured by EDSS scores), with 84.6% of patients improving their disability score after AHSCT at month six and 76.9% at one year. Additionally, 76.9% of patients showed stable disability scores two years after the transplant.

The findings of EDSS improvement in almost 85% of the patients suggest that disability may be often at least temporarily reversible in patients with highly active [relapsing] MS if they receive suitable and well-timed treatment, the researchers wrote.

Using appropriate statistical models, researchers found that the clinical variable that explained the disability regression at months 6 and 12 after AHSCT was the disability progression over 6 months before AHSCT.

Improvements in cognition after AHSCT also were observed. Specifically, the scores of information processing speed and verbal learning, measured by the symbol digit modalities test, were significantly higher at month 12 after AHSCT (56.8) when compared to month three (48.3).

The score of brief visuospatial memory test revised that assesses visuospatial memory was slightly lower at month three (25.6) than before AHSCT (27.8), however, the difference was not significant.

The score of the California verbal learning test, which assesses verbal learning, was significantly higher at month 12 (63.6) than before AHSCT (55.2).

No new or active lesions were found on MRI after AHSCT, suggesting that all patients remained without radiological disease activity.

Furthermore, regarding safety, the incidence and severity of adverse events (side effects) after AHSCT were in the expected range and all were resolved. There were no transplant-related deaths reported.

Researchers noted several limitations to the studys findings, including the low sample size and the fact that the patientss assessment and follow-ups were provided at the same center without a comparative group.

Nonetheless, the outcomes are highly promising, as compared to conventional MS treatment, the researchers wrote. Further research is needed to replicate these findings and to assess long-term outcomes and safety of AHSCT.

Diana holds a PhD in Biomedical Sciences, with specialization in genetics, from Universidade Nova de Lisboa, Portugal. Her work has been focused on enzyme function, human genetics and drug metabolism.

Total Posts: 1,053

Patrcia holds her PhD in Medical Microbiology and Infectious Diseases from the Leiden University Medical Center in Leiden, The Netherlands. She has studied Applied Biology at Universidade do Minho and was a postdoctoral research fellow at Instituto de Medicina Molecular in Lisbon, Portugal. Her work has been focused on molecular genetic traits of infectious agents such as viruses and parasites.

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Creative Medical Technology Holdings Announces Successful Application of ImmCelz Immunotherapy for Treatment of Stroke – PRNewswire

Posted: December 16, 2020 at 10:57 am

PHOENIX, Dec. 16, 2020 /PRNewswire/ --Creative Medical Technology Holdings Inc., (OTC CELZ) announced today positive preclinical data supporting the utilization of its ImmCelz cell based immunotherapy for treatment of stroke. In an animal model of ischemia stroke, the middle cerebral artery ligation model, administration of ImmCelz resulted in 34% reduction in infarct volume, whereas control bone marrow mesenchymal stem cells reduced infarct volume by 21%. Additionally, improvements in functional recovery where observed using the Rotarod test. At 28 days after induction of stroke the animals receiving ImmCelz had superior running time (92% of non-stroke controls) compared to animals which received bone marrow mesenchymal stem cells (73% of non-stroke control). Animals that received saline had a running time that was 50% of non-stroke controls.

"The regenerative potential of immune cells that have been programmed by stem cells is a fascinating and novel area of research." Said Dr. Amit Patel, coinventor of ImmCelz, and board member of the Company. "Conceptual advantages of using reprogrammed T cells include higher migratory ability due to smaller size, as well as ability to replicate and potentially form "regenerative memory cells."

"This data, which is covered by our previous filed patents, such as no. 15/987739, Generation of autologous immune modulatory cells for treatment of neurological conditions, demonstrate that immune modulation via this stem cell based method may be a novel and superior way of addressing the $30 billion dollar market for stroke therapeutics1." Said Dr. Thomas Ichim, coinventor of the patent and Chief Scientific Officer of the Company. "The fact that this technology, which has priority back to 2017, is demonstrating such stunning results, motivates us to consider filing an Investigational New Drug Application for use in stroke."

Creative Medical Technology Holdings possesses numerous issued patents in the area of cellular therapy including patent no. 10,842,815 covering use of T regulatory cells for spinal disc regeneration, patent no. 9,598,673 covering stem cell therapy for disc regeneration, patent no. 10,792,310 covering regeneration of ovaries using endothelial progenitor cells and mesenchymal stem cells, patent no. 8,372,797 covering use of stem cells for erectile dysfunction, and patent no. 7,569,385 licensed from the University of California covering a novel stem cell type.

"While stroke historically has been a major area of unmet medical need, the rise in stroke cases , as well as the fact that younger people are increasingly falling victim to stroke, strongly motivates us to accelerate our developmental programs and to continue to explore participation of Big Pharma in this space." Said Timothy Warbington, President and CEO of the Company. "We are eager to replicate the existing experiments start compiling the dossier needed to take ImmCelz into humans using the Investigational New Drug Application (IND) route through the FDA."

About Creative Medical Technology Holdings

Creative Medical Technology Holdings, Inc. is a commercial stage biotechnology company specializing in stem cell technology in the fields of urology, neurology and orthopedics and trades on the OTC under the ticker symbol CELZ. For further information about the company, please visitwww.creativemedicaltechnology.com.

Forward Looking Statements

OTC Markets has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This news release may contain forward-looking statements including but not limited to comments regarding the timing and content of upcoming clinical trials and laboratory results, marketing efforts, funding, etc. Forward-looking statements address future events and conditions and, therefore, involve inherent risks and uncertainties. Actual results may differ materially from those currently anticipated in such statements. See the periodic and other reports filed by Creative Medical Technology Holdings, Inc. with the Securities and Exchange Commission and available on the Commission's website atwww.sec.gov.

Timothy Warbington, CEO[emailprotected] CreativeMedicalHealth.com

Creativemedicaltechnology.comwww.StemSpine.comwww.Caverstem.comwww.Femcelz.com

1 Stroke Management Market Size Forecasts 2026 | Statistics Report (gminsights.com)

SOURCE Creative Medical Technology Holdings, Inc.

http://creativemedicaltechnology.com

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Stem Cell Exosomes Market: Increasing advanced applications of exosomes is expected to drive the market – BioSpace

Posted: December 16, 2020 at 10:57 am

Stem Cell Exosomes Market: Overview

Exosomes possesses the potential to be a carrier for drug delivery owing to their transportation properties. The stem cell exosomes have other properties of high biocompatibility and intrinsic long-term circulation, which are ideal for proteins, nucleic acids, and chemicals. Additionally, new researches showed results of exosomes possessing properties of mediators in intercellular communication and mRNA transcripts, delivering proteins, and many others. They have properties, which make them biocompatible and useful to become agents to provide treatment for various disorders.

The rapidly increasing interest for advanced material to provide disease-based treatment in case of emergency is inducing more research and funding to explore stem cell exosomes. This is a key factor driving growth of the stem cell exosomes market from past few years and is estimated to be the same for next few years as well.

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Stem Cell Exosomes Market: Notable Development

The stem cell exosomes market is identified as highly competitive without dominant players owing to many players operating in the market. Some of the key players in the market include Anjarium Biosciences, Codiak Biosciences, Capricor Therapeutics, Creative Medical Technology Holdings, Evox Therapeutics, Everkine Corporation, Exogenus Therapeutics, ReNeuron, Kimera Labs, and Unicyte AG.

The market is witnessing lucrative investments for adoption of newer and improving technologies. Such investments are on grounds of few acquisitions and mergers, tie ups, and to cater to global population.

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Some of few developments observed in the market:

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Stem Cell Exosomes Market: Growth Factors

The factors impacting on growth of the market include increasing prevalence of cancer and advent of technological advancements in exosomes and its applications. Additionally, increasing advanced applications of exosomes coupled with increasing awareness about presence of improved medical techniques are propelling growth of the global stem cell exosomes market. The 2012 reports by World Health Organization (WHO), the number of patients is expected to increase by 70% in next two decade. Increase in patients may lead to increase in fatality due to cancer, which increase attention toward advanced medications. This factor is likely to boost demand for the exosomes in diagnosis and therapeutics.

However, number of technical difficulties are limiting its adoption globally and hindering growth of the global stem cell exosomes market. The other factors restraining market growth are stringent regulatory frameworks and commercialization of exosomes. Nonetheless, the factors such as increase in research coupled with funding for researches are estimated to open doors of opportunities for growth in coming future.

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1st Patients To Get CRISPR Gene-Editing Treatment Continue To Thrive – NPR

Posted: December 16, 2020 at 10:57 am

Victoria Gray (second from left) with children Jamarius Wash, Jadasia Wash and Jaden Wash. Now that the gene-editing treatment has eased Gray's pain, she has been able be more active in her kids' lives and looks forward to the future. "This is really a life-changer for me," she says. Victoria Gray hide caption

Victoria Gray (second from left) with children Jamarius Wash, Jadasia Wash and Jaden Wash. Now that the gene-editing treatment has eased Gray's pain, she has been able be more active in her kids' lives and looks forward to the future. "This is really a life-changer for me," she says.

The last thing a lot of people want to do these days is get on a plane. But even a pandemic would not stop Victoria Gray. She jumped at the chance to head to the airport this summer.

"It was one of those things I was waiting to get a chance to do," says Gray.

She had never flown before because she was born with sickle cell disease. She feared the altitude change might trigger one of the worst complications of the devastating genetic disease a sudden attack of excruciating pain.

But Gray is the first person in the United States to be successfully treated for a genetic disorder with the help of CRISPR, a revolutionary gene-editing technique that makes it much easier to make very precise changes in DNA.

About a year after getting the treatment, it was working so well that Gray felt comfortable flying for the first time. She went to Washington, D.C., to visit her husband, who has been away for months on deployment with the National Guard.

"It was exciting. I had a window. And I got to look out the window and see the clouds and everything," says Gray, 35, of Forest, Miss.

Gray wore a mask the whole time to protect herself against the coronavirus, kept her distance from other people at the airport, and arrived happily in Washington, D.C., even though she's afraid of heights.

"I didn't hyperventilate like I thought I would," Gray says, laughing as she recounts the adventure in an interview with NPR.

NPR has had exclusive access to follow Gray through her experience since she underwent the landmark treatment on July 2, 2019. Since the last time NPR checked in with Gray in June, she has continued to improve. Researchers have become increasingly confident that the approach is safe, working for her and will continue to work. Moreover, they are becoming far more encouraged that her case is far from a fluke.

At a recent meeting of the American Society for Hematology, researchers reported the latest results from the first 10 patients treated via the technique in a research study, including Gray, two other sickle cell patients and seven patients with a related blood disorder, beta thalassemia. The patients now have been followed for between three and 18 months.

All the patients appear to have responded well. The only side effects have been from the intense chemotherapy they've had to undergo before getting the billions of edited cells infused into their bodies.

The New England Journal of Medicine published online this month the first peer-reviewed research paper from the study, focusing on Gray and the first beta thalassemia patient who was treated.

"I'm very excited to see these results," says Jennifer Doudna of the University of California, Berkeley, who shared the Nobel Prize this year for her role in the development of CRISPR. "Patients appear to be cured of their disease, which is simply remarkable."

Another nine patients have also been treated, according to CRISPR Therapeutics in Cambridge, Mass., and Vertex Pharmaceuticals in Boston, two companies sponsoring the research. Those individuals haven't been followed long enough to report any results, officials say.

But the results from the first 10 patients "represent an important scientific and medical milestone," says Dr. David Altshuler, Vertex's chief scientific officer.

The treatment boosted levels of a protein in the study subjects' blood known as fetal hemoglobin. The scientists believe that protein is compensating for defective adult hemoglobin that their bodies produce because of a genetic defect they were born with. Hemoglobin is necessary for red blood cells to carry oxygen.

Analyses of samples of bone marrow cells from Gray six months after getting the treatment, then again six months later, showed the gene-edited cells had persisted the full year a promising indication that the approach has permanently altered her DNA and could last a lifetime.

"This gives us great confidence that this can be a one-time therapy that can be a cure for life," says Samarth Kulkarni, the CEO of CRISPR Therapeutics.

Gray and the two other sickle cell patients haven't had any complications from their disease since getting the treatment, including any pain attacks or hospitalizations. Gray has also been able to wean off the powerful pain medications she'd needed most of her life.

Prior to the treatment, Gray experienced an average of seven such episodes every year. Similarly, the beta thalassemia patients haven't needed the regular blood transfusions that had been required to keep them alive.

"It is a big deal because we we able to prove that we can edit human cells and we can infuse them safely into patients and it totally changed their life," says Dr. Haydar Frangoul at the Sarah Cannon Research Institute in Nashville. Frangoul is Gray's doctor and is helping run the study.

For the treatment, doctors remove stem cells from the patients' bone marrow and use CRISPR to edit a gene in the cells, activating the production of fetal hemoglobin. That protein is produced by fetuses in the womb but usually shuts off shortly after birth.

The patients then undergo a grueling round of chemotherapy to destroy most of their bone marrow to make room for the gene-edited cells, billions of which are then infused into their bodies.

"It is opening the door for us to show that this therapy can not only be used in sickle cell and thalassemia but potentially can be used in other disorders," Frangoul says.

Doctors have already started trying to use CRISPR to treat cancer and to restore vision to people blinded by a genetic disease. They hope to try it for many other diseases as well, including heart disease and AIDS.

The researchers stress that they will have to follow Gray and many other patients for a lot longer to be sure the treatment is safe and that it keeps working. But they are optimistic it will.

Gray hopes so too.

"It's amazing," she says. "It's better than I could have imagined. I feel like I can do what I want now."

The last year hasn't always been easy for Gray, though. Like millions of other Americans, she has been sheltering at home with three of her children, worrying about keeping them safe and helping them learn from home much of the time.

"I'm trying to do the things I need to do while watch them at the same time to make sure they're doing the things they need to do," Gray says. "It's been a tough task."

But she has been able do other things she never got to do before, such as watch her oldest son's football games and see her daughter cheerleading.

"This is really a life-changer for me," she says. "It's magnificent."

She's now looking forward to going back to school herself, learning to swim, traveling more when the pandemic finally ends, and watching her children grow up without them worrying about their mother dying.

"I want to see them graduate high school and be able to take them to move into dorms in college. And I want to be there for their weddings just everything that the normal people get to do in life. I want to be able to do those things with my kids," she says. "I can look forward now to having grandkids one day being a grandmama."

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How to Stay ‘Body Positive’ with Diabetes – Healthline

Posted: December 14, 2020 at 6:00 pm

The long-term impacts of negative body image can be devastating. And what worries experts is that it only takes one comment to send someone down a dangerous road. If diabetes is involved, the effects can be compounded.

Its the well-meaning doctor who says something like you better clean up your act or youre going to have type 2 diabetes, Nicole Patience, a nutrition and diabetes educator, and eating disorders specialist at Joslin Diabetes Center in Boston, tells DiabetesMine.

Dr. Samar Hafida, staff physician at Joslin, agrees. She is the assistant medical director of global education and care and a weight management and clinical nutrition specialist.

Its not uncommon; in fact, a majority of people have had this experience, she tells DiabetesMine. A person comes in (to their medical provider) with a non-weight-connected complaint, and the suggestion is lose weight and youll feel better.

The result of those kinds of experiences compounded by the worlds focus on thin as beautiful can be the proving ground for depression, self-loathing, and devastating eating disorders. Thats an impact that can hit anyone in society, she says.

For people with diabetes (PWDs), this can be devastating as they are also faced with blame over their disease by an uneducated general public, comments from the medical field on how weight reduction or diet change is the center of everything, and the challenge of living with a body one feels is failing them.

Could a new focus on body positivity be the solution?

Experts feel this movement can and will help PWDs not only feel better about themselves psychologically but be healthier overall.

While it may feel like a new buzz phrase to some, the body positivity movement has been around since the late 1960s when women first started pushing back on the notion that all women should be thin.

It took off in recent years for a number of reasons. First, in the late 90s, a psychotherapist named Connie Sobczak struggling with an eating disorder morphed her background and personal experience to create http://www.thebodypositive.org, a site dedicated to helping people with self-acceptance.

Then, around 2012, the Body Positive movement took root with bloggers, celebrities, medical experts, and researchers all pushing for the public to not just accept but embrace the concept of all bodies being beautiful.

In recent years, celebrities like singer Lizzo have been vocal and visible in the movement, bringing even more attention to it. The recent October 2020 Fenti fashion show from singer Rihanna featured models of all sizes, colors, and looks in a nod to body positivity.

Joslins Patience says that its all about taking care of the body you live in. Its about respecting it and recognizing how it serves you in very positive ways.

What body positivity is not, she says, is a call to ignore healthy suggestions and interventions that you may need.

Some see it as a double-edged sword, explains Hafida. Some worry that embracing oneself as you are will block people from accepting (medical help). But its not an either/or concept. Being body positive should not mean youre not receptive to taking advice and taking action.

What it does mean is this: Loving the body you are in as it is in this moment leads to better health outcomes overall.

Its a difficult thing to embrace for the overweight, Hafida says.

Society tells us we need to look a certain way, be a certain way. Thats hard to overcome.

For the PWD of any kind, the challenge of finding body positivity is exacerbated by the need to wear medical devices, the struggle with weight control some face, things like scarring on the body, and just the feeling, overall, that your body has failed you.

And there is of course the stigma and blame that the general public associates with any type of diabetes.

Even with type 1 (and often with type 2), others say, Oh, you must have caused your diabetes, says Patience.

She points out that her first step with a patient is reminding them that with type 1 or type 2 diabetes: This is not your fault.

There is no reason to blame yourself, she says. Body size is not a direct indication of whether you take care of yourself or not.

There are other specific other body image challenges that come with diabetes, she adds, pointing to these as just a few:

All this can lead to dangerous reactions in PWDs.

Marcia Meier, program manager at the Patient Services International Diabetes Center in St. Louis Park, Minnesota, has treated over 500 diabetes patients with eating disorders and other body-related struggles since 2005.

The ugly truth, she tells DiabetesMine, is that the impact of negative body image on PWDs, particularly women, can be profound.

About 36 to 40 percent of women with type 1 diabetes manipulate insulin to control their weight, she says.

There is this concept of insulin use equals fat, and right there, youve got a predisposition to some of those problems.

Meier traces the issue back to the general public, of course, but also to a place that may surprise many: the endocrinology office.

Just about every article you read, all that you can pick up right in your endocrinology office, clearly says that insulin causes weight gain, she says.

Most women want to be a body size that is smaller than they are, diabetes or not, she says.

The dangerous difference between the PWD? Access to a relatively simple yet life-risking way to drop the weight.

Most people do not have the kind of touch on the body that people with diabetes do, she says. All a person with diabetes had to do to lose weight is not do something. They dont have to exercise or starve. They just have to omit their insulin.

Of the patients shes treated, she says negative body image has been a part of (the struggle) of every single one of them.

Its not always insulin omission, though. Shes had a diabetes patient who purposely let her glucose levels run low because she only gave herself permission to eat when low.

This drive to be thin does not necessarily stem from being raised in a household judging you. In fact, Meier says, even the person raised with all the right cues can fall prey to public comment.

Thats a huge challenge I see. You can be raised (with body positivity) in your household and literally delve into an eating disorder from one thing a person says.

It could be as simple as your aunt saying you should skip the dessert so you dont get fatter and worse with your diabetes. Or a magazine spread with the plus-sized models who are actually a size 8 or 10. Or the doctor who tells you your weight is the cause of all troubles. One negative comment is all it takes, she says, to set a person down a dangerous road.

Like so many other things, this takes a village. PWDs need the world, media and yes, their own doctors, to understand and embrace this, experts say. They also need themselves.

Some ways to build body positivity include:

It starts with you. Patience says when a person meets with her for the first time, shes quick to strike down any self-negativity.

People come in and make derogatory remarks about themselves because its been normalized so much, she says. I tell them right away: its not acceptable here.

She helps those struggling learn, understand, and, most of all, embrace seeing that their body does many good things for them every day and that loving it for that helps overall health.

Meier agrees, adding that while society needs change here, I cannot change the world. What I can do is help them deal with those comments.

They need to develop a belief system so that when things are said to them (even by doctors), they can recognize that even if coming as well-intentioned those comments may not be healthy for them, or even be the truth. Its about not believing everything you hear and read.

PWDs also need to recognize the good that both their body and insulin does, Meier says, as well as the good technology they may wear does.

For example, beauty queen Sierra Sandison was a teenager when diagnosed with type 1 diabetes, and due to body image notions, she pushed off getting a pump and CGM for a period of time.

I was a senior in high school and already having a hard time with body image when I was diagnosed, she tells DiabetesMine.

I was angry at my body before that, and once I was diagnosed, I was angry at it for what I saw as failing me on the inside too.

She decided to hide her diabetes until she heard about Miss America 1999 Nicole Johnson, who has type 1 and proudly displays it.

That led Sandison to make it into the 15 finalists for Miss America as Miss Idaho 2014, where she walked the stage in the bathing suit competition proudly showing her pump. Thousands followed her lead, making the hashtag #ShowMeYourPump go viral, and more importantly helping others heal as she did herself.

Now Im like: if someone does not want to date me because I have a pump, good riddance, she says.

Finding medical support that gets it. Patience is one of more than 17,000 medical providers who have signed on as part of the Healthy At Every Size movement that provides resources and encourages healthcare professionals to take a pledge to be aware, respectful, and compassionate of all issues surrounding body size.

More and more providers are adopting this, and Patience suggests you seek them out, or ask your medical provider to check it out.

Hafita said it can be life-changing when you seek out a medical expert who understands that if you are a bit overweight, it makes no sense to focus on fault.

Weight gain is a chronic disease, she says. No matter how many mistakes you think you have made, its not your fault.

She asks people to consider this: Some of our friends can gobble down all the goodies, barely work out and be thin. Others walk daily, count carbs and still struggle with weight.

Seeing someone who can understand is key, she says.

Avoid rash diets, particularly for children. Keto eating, for example, can be too extreme, Hafita said.

That is absolutely not normal eating, she explains, in large part because it is so difficult to maintain. There are people who think you can eat that way for the rest of their life, but the reality is, much of our social structure centers around food. We celebrate with it; we gather around it. Its not the best idea to raise a child to think they are failing if they enjoy those moments.

Know when to take action. If you struggle with body image issues and have ever omitted insulin or starved yourself, you may want to seek a therapist to help you build a better image of yourself.

That can range from a therapist you connect with to a trained expert in diabetes and body image.

In the end, learning to embrace our bodies as they are, big or small; dark or light; tall or short; whatever you are, is key to overall health, all agree.

Its important to understand, as I now do, that healthy looks different on everyone, says Sandison.

We have to get past this skinny is healthy concept and we should strive for all to do that, she concludes.

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Could You Be Prediabetic or Diabetic and Not Know It? The Signs – The Beet

Posted: December 14, 2020 at 6:00 pm

With 88 millionAmericans or approximately 1 in every 3 adults,suffering from prediabetes in this country (and 34 million Americans, or 1 in 10, with full-blown type 2 diabetes), many people are walking around with a ticking time bomb in their bodies, and don't even know they have the condition.

Prediabetes is when your blood sugar level is higher than it should be for optimal health, butnot high enough for your doctor to diagnose the disease.It's also known asimpaired fasting glucose or glucose intolerance. The scary part is, 90 percent of those with prediabetes dont know that they have it.

We have all heard that excessive thirst or urinating more often than normal is a sign that you could have diabetes, but what are the telltale signals that you may be pre-diabetic? Why does it matter? The sooner you find out the better, for your health and to know that changing your lifestyle can alter the course of the disease and head it off at the pass.

Prediabetes, unlike diabetes, is an asymptomatic condition. The soonersomeone finds out that they are prediabetic the better, experts say, since it's possible to make lifestyle changes that can reverse your health and get you back onto a healthy path, with simple switches like eating more plant-based foods, losing a small amount of body weight, and being more active, such as walking 30 minutes a day, five days a week.

"Prevention is the best medicine!If you are given a prediabetes or diabetes diagnosisdo not despair," since you can make simple lifestyle changes (exercise, diet, and losing a small amount of weight) to reverse course on the disease, saysKellie Antinori-Lent, MSN, RN, andPresident of the Association of Diabetes Care and Education Specialists (ADCES) and diabetes clinical nurse specialist at the University of Pittsburgh Medical Center, Shadyside Hospital in Pittsburgh.

"If someone is at risk for developing prediabetes or diabetes, they should schedule an appointment with their doctor to discuss their concerns and questions. The best first place to begin is with a visit to your providerwhether in person or virtualand dont delay," says Antinori-Lent. Prevention is the best medicine!If you are given a prediabetes or diabetes diagnosisdo not despair!" There are simple things you can do to dial back the condition such as exercise 30 minutes a day, lose 7 to 10 percent of your body weight, and eat a mostly whole-food, plant-based diet, high in fiber and low in added sugars and chemicals.

How do you know if you have diabetes or prediabetes? We asked Antinori-Lent,who makes it her life's work to educate people about the changes they can make to ensure their future health, and here is what she had to tell us:

Kellie: That is a really good question, however, prediabetes does not have symptoms. There is a physical sign of insulin resistance, which is associated with prediabetes. This sign is darkened skin in areas such as the neck, under the arms, and elbows. Some people mistake it as an area of skin they didn't wash wellbut you cannot wash acanthosis nigricans (the name of the dark skin areas). Instead, there are risk factors. These include:

Keep in mind that prediabetes can develop into type 2 diabetes if left untreated. People can prevent this from happening by evaluating their lifestyle habits, including changing their diet, increasing their exercise and activity levels and seeing their doctor regularly, and working withhim or her to prevent the progression.

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Could You Be Prediabetic or Diabetic and Not Know It? The Signs - The Beet

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Weight-loss surgery most effective treatment for type 2 diabetes patients – The Irish Times

Posted: December 14, 2020 at 6:00 pm

Metabolic surgery can free two-thirds of patients with type 2 diabetes from the use of insulin, new research suggests.

An analysis of post-surgery outcomes of nearly 2,000 patients with obesity and diabetes requiring insulin, co-ordinated by the Irish Society for Clinical Nutrition and Metabolism (Irspen) and the British Obesity and Metabolic Surgery Society found that surgery is more effective and cheaper than insulin.

Some 67 per cent of patients were no longer using insulin one year after metabolic surgery and 37 per cent achieved remission of their diabetes altogether, the analysis found.

Metabolic surgery is a term used to describe weight loss treatments and procedures, such as a gastric bypass, to treat metabolic diseases such as diabetes in obese people.

The research included a broad cohort of patients across Ireland and the UK and analysed their outcomes between 2009 and 2017.

Prof Helen Heneghan from the National Metabolic Surgery Centre at St Vincents hospital, said on average patients also lost around a quarter of their bodyweight and the improvements persisted for at least four years.

Prof Heneghan said prior to this analysis, questions remained if surgery would be as effective for patients with type 2 diabetes requiring insulin, as these patients also have a higher chance of diabetes complications.

This research now confirms metabolic surgery is also the most effective medical treatment for the majority of patients with more severe type 2 diabetes who use insulin, she said.

Type 2 diabetes develops when the body becomes resistant to insulin or when the pancreas is unable to produce enough insulin. Obesity and age both increase the risk of developing type 2 diabetes.

There are more than 200,000 people living with diabetes in Ireland, according to Diabetes Ireland, most of whom have type 2 diabetes.

In a second part of the study, Irspen member Prof Carel le Roux said surgery was also found to be more cost effective than medication.

The researchers costed the surgery against if the same patients had been treated with medicines alone. Although an operation costs 8,000, researchers found that this figure was less than the ongoing cost of medications, she said.

With costs of treatment side-effects and any complications of diabetes were also considered, the average patient treated with surgery was expected to save the health system 4,000 over five years, while also living with better health outcomes.

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How to Check Blood Sugar Without a Meter: Is It Possible? – Healthline

Posted: December 14, 2020 at 6:00 pm

Diabetes is a chronic condition where the body either doesnt make enough insulin or doesnt use insulin properly or both. This can lead to a higher than normal blood sugar level.

Uncontrolled blood sugar levels can lead to complications, such as:

For these reasons, its important to monitor your blood sugar if you have diabetes.

Prior to using meters, people with diabetes would monitor their blood sugar by testing their urine. This method, however, wasnt as accurate, nor did it provide real-time results.

If you self-test your blood sugar several times a day using a glucometer, or meter, it requires that you prick your finger to draw blood to test. Due to the discomfort of this method, you might look for a way to monitor your level without this tool.

If finger pricks are very bothersome for you, dont worry theres hope. Advances in blood sugar monitoring technology could mean no more finger pricks in the future.

If you have diabetes, there are several portable devices you can use to check your blood sugar level and not all of them require a finger prick.

The one device that does require a finger prick is a meter. This is the most widely available and affordable option.

To use this device, youll insert a test strip into the meter. Youll prick your finger to retrieve a sample of blood, and then place the sample on the edge of the test strip to check your blood sugar.

Glucometers are convenient because theyre small and portable, allowing you to use them anywhere. Your blood sugar results are also accurate and instant.

You can also use a continuous glucose monitor (CGM) to check your blood sugar. This is different from glucometers, which can only monitor blood sugar when you test your blood.

Continuous glucose monitoring, on the other hand, provides real-time glucose, or blood sugar, readings every few minutes. These systems involve the insertion of a tiny sensor underneath your skin (usually in the abdomen).

This sensor measures your interstitial glucose level, and then sends the information to a pager-like monitor, or an app on your phone. An alarm sounds if your blood sugar becomes too high or too low.

Even though continuous glucose monitoring systems place a sensor under the skin, most still require a finger prick at least once a day to calibrate the device.

This is less than the number of finger pricks with a glucometer, which can require four or more per day.

The Freestyle Libre system is another way to check your blood sugar. While this method has certain features in common with a CGM and a meter, it stands out for one reason: It doesnt require a finger prick.

Youll still have a tiny sensor inserted underneath your skin with the Freestyle Libre. Its different from a CGM in that you wont get continuous readings.

But, rather than prick your finger, like you would with a meter, youll use a reader to scan the sensor when you want to check your blood sugar level.

Again, urine is another way to measure sugar levels. This involves inserting a test strip into your urine. The problem, though, is that test strips can only detect sugar in your urine they cant provide an exact blood sugar reading.

Unfortunately, this method of checking blood sugar isnt convenient since youll need a container to collect the urine. Also, it only works when urine hasnt been sitting in your bladder for too long.

Fingertips have more nerve endings, so this part of the finger tends to be the most sensitive.

If you use a finger prick to check your blood sugar level, a few techniques can make the process less painful whether youre using a glucometer or a continuous glucose monitor.

Blood sugar testing is crucial to diabetes management because high or low blood sugar can cause severe complications. If too much blood sugar accumulates in your bloodstream, you can experience major complications such as:

Signs of high blood sugar include:

Signs of low blood sugar can include:

Blood sugar can fluctuate throughout the day especially after meals, after exercising, and during stressful events. So its important to carefully monitor your blood sugar and keep it within a healthy range.

A blood sugar level less than 140 milligrams per deciliter (7.8 millimoles per litre), but greater than 70 mg/dL (3.9 mmol/L) is typically considered in the target range.

You should check your blood sugar regularly, even if you arent experiencing symptoms of a high or low glucose level. Some people with high and low blood sugar dont have any symptoms.

Even though you can monitor blood sugar level with glucometers and CGMs, the future might provide additional ways to manage your diabetes.

Testing your blood sugar is crucial to diabetes management. Using a meter or continuous glucose monitoring can provide accurate results. But you might seek a pain-free method to check blood sugar.

Talk with your doctor or a certified diabetes educator. You might be a candidate for a glucose monitoring device that involves fewer finger pricks or no finger pricks.

Additionally, making a few adjustments in the way you collect your blood sample might reduce the level of pain and discomfort.

Diabetes is a life-long, chronic condition that involves careful monitoring of your blood sugar. This can prevent serious complications such as nerve damage and stroke.

Discuss options for monitoring blood sugar with your doctor to find a device that suits your comfort level.

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Diabetes: Handful of these nuts can help you manage blood sugar levels – TheHealthSite

Posted: December 14, 2020 at 6:00 pm

Diabetes is one of the major health concerns, affecting millions of people across the world. It is a lifestyle disease, meaning what you eat and how much you move plays a pivotal role in keeping your blood sugar levels in control. One food that can help you manage diabetes is nuts. These minuscule delights can easily be added to your diet and provide a multitude of health benefits. Also Read - Coronavirus: Diabetes in patients post Covid-19 recovery

Nuts are a powerhouse of nutrients that can help you improve your health in more ways than one. They are loaded with antioxidants, fibre, protein, unsaturated fats, phytochemicals, vitamins and minerals. Although nuts are high in fat, they are high inhealthy fats (monounsaturated and polyunsaturated) and low in unhealthy fats (saturated fats). Also Read - Diabetes: Can fenugreek help manage blood sugar levels? Let's find out

Nuts are touted as one of the best foods for metabolic syndrome and type-2 diabetes. According to a study published in the Journal of the American College of Nutrition, regular consumption of nuts can decrease the prevalence of diseases such as cardiovascular diseases, metabolic syndrome and type 2 diabetes. Also Read - Diabetes: Not just sugar, stay away from these foods to keep diabetes at bay

Nuts are low in carbs, which makes them a great alternative for high-carb foods that cause a blood sugar spike. Some nuts like almonds, peanuts and pistachios help alleviate bad cholesterol levels, too much of which can cause the arteries to narrow down. They also have a low glycemic index, which is great for people with diabetes.

But not all nuts are created all. Some nuts are more beneficial to diabetics than others. Here is a list of nuts you can add to your diet.

Almonds generally offer many nutritional benefits, but they are extremely beneficial for people with diabetes. Studies, over the years, have shown that almonds may alleviate the risk of blood sugar and reduce insulin levelsafter meals. They are also high in magnesium, which can help alleviate the risk of developing type 2 diabetes.

A study published in the Journal of Nutrition found that a cashew-enriched diet can help reduce blood pressure and control cholesterol levels. Including cashews in the diet also had a positive effect on blood glucose levels.

Walnuts are a great source of dietary fibre. Fibres take more time to digest, thereby slowing down the release of sugar in the bloodstream. This helps build resistance for insulin, control blood levels and even mitigate the risk of developing type-2 diabetes. The GI of walnuts is also low.

Pistachios contain healthy fats, antioxidants, fibre and protein all of which is healthy for diabetics. Like other nuts on the list, it also has a low GI. It also contains components that help relieve stress, induce sleep and improve overall health.

Rich in dietary protein, vitamin E, amino acids, polyphenolic antioxidants and dietary fibre, peanuts are an excellent option for diabetics. They are packed with essential B-vitamins and many other essential nutrients. With a GI index of 14, this wonder nut can help manage blood sugar. Magnesium in peanuts is also a plus.

Nuts like almonds, cashews, pistachios, peanuts and walnuts are good for diabetics. The best way to manage blood sugar levels is to eat a handful of nuts regularly. However, you must avoid the ones with added salt or other flavours. Also, it is essential to consult your doctor before making any changes in your diet.

Published : December 14, 2020 1:06 pm | Updated:December 14, 2020 1:08 pm

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Diabetes: Handful of these nuts can help you manage blood sugar levels - TheHealthSite

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Dogs and owners may share resemblance in diabetes risk – The Guardian

Posted: December 14, 2020 at 6:00 pm

Its said that dogs resemble their owners, but the similarities may also extend to their risk of diabetes, research suggests. The same cannot be said of cat owners and their companions, however.

Previous studies had hinted that overweight owners tend to have porkier pets, possibly because of shared health behaviours such as overeating or not taking regular exercise. To investigate whether this extended to a shared risk of type 2 diabetes, Beatrice Kennedy, of Uppsala University in Sweden, and colleagues turned to insurance data from Swedens largest pet insurance company, using owners 10-digit national identification numbers to pull their anonymised health records.

Comparing data from 208,980 owner/dog and 123,566 owner/cat pairs, they discovered that owning a dog with diabetes was associated with a 38% increased risk of having type 2 diabetes compared with owning a healthy hound. Personal and socioeconomic circumstances of the dog owners could not explain this link. No shared risk of diabetes was found between cat owners and their pets, however. The research was published in the British Medical Journal.

As in humans, diet and obesity can influence the risk of type 2 diabetes in both types of animals. Also like humans, the prevalence of diabetes in dogs and cats appears to be on the increase.

Given the previous research on the shared risk of [being overweight] between dog owners and their animals, we believe that shared dietary habits and also physical activity levels might be involved, said Kennedy.

The absence of a shared risk between cats and their owners may also point towards physical activity being an important factor. Cats usually prefer more independence from their owners when it comes to their movements, Kennedy said.

Shared environmental exposures to things such as pollutants or chemicals between dogs and their owners could be another avenue worth exploring, she added. Because this was an observational study, the researchers could not confirm the underlying cause of the association.

However, given that it exists, a diagnosis of diabetes in any household member including canine companions could signal a need to reassess the health behaviours of the whole family unit. The diabetes of the dog could be a marker of something important going on, Kennedy said. We know that there are quite strong emotional bonds between dog owners and their dogs. Perhaps that bond extends to other health behaviours and risks.

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