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Integrative Medicine: What Is It, Types & Benefits | Fullscript

Posted: October 16, 2023 at 8:07 pm

Welcome to Fullscripts integrative medicine education series. Discover how integrative medicine improves patient outcomes and why its being adopted by forward-thinking practitioners across North America.

One of the key tenets of integrative medicine is that good medicine is based on good science, which is inquiry-driven and open to new paradigms. (22) Integrative medicine is good medicine and so much more.

In this article, youll learn what integrative medicine is, the benefits of it, and more.

Integrative medicine can be described and defined in different ways. But for the most comprehensive description, it helps to refer to the Father of Integrative Medicine, Dr. Andrew Weil.

The Andrew Weil Center for Integrative Medicine describes integrative medicine as healing-oriented medicine that considers the whole person within the context of a collaborative therapeutic relationship between practitioner and patient. It is informed by scientific evidence, uses all appropriate integrative therapies, and is guided by the defining principles outlined in the graphic below.

In addition to treating the physical body, integrative medicine treats patients via emotional, environmental, mental, and spiritual means by integrating mind and body with a holistic approach. (5)

Other keywords often used to define integrative medicine include empowering, evidence-based, individualized, interprofessional, and patient-centered. (17) According to a 2009 paper on the topic of integrative medicine and patient-centered care, the authors explain that patient-centered care is a core component of integrative medicine and has a movement all its own, which is rooted in customized treatments and decision-making based on the patients beliefs and preferences. (8)

Download our free clinical guide for evidence-based education on supplement basics, drug-nutrient depletions, protocol development, and more medically-reviewed by real practitioners.

Many people wonder how integrative medicine relates to conventional or Western medicine. Integrative medicine is an approach to health and wellness that combines:

Many licensed healthcare practitioners provide integrative care to their patients. Examples of practitioners and doctors who may practice integrative care include:

Individuals of all ages and those with varying health conditions may benefit from integrative medicine. Integrative medicine can help promote overall health and well-being and aid in chronic disease management and prevention. (11)

Dietary supplements are the most commonly used integrative modality; however, other popular approaches include therapeutic breathing techniques, diet therapy, and yoga. (10) Integrative medicine further incorporates a variety of integrative therapies including acupuncture, Ayurveda, chiropractic, homeopathic, naturopathic, and traditional Chinese medicine alongside conventional medicine. (20)

Examples of complementary therapies include:

How does integrative medicine differ from alternative, complementary, and conventional medicine?

When a provider or medical facility utilizes both complementary and conventional medical care, it is considered integrative medicine. (12)

There are significant events that have taken place over the past 50 years that have helped form integrative medicine as we know it is today. Here is a timeline illustrating some of those key events. (1)(9)(13)(17)(19)

Today its estimated that more than one third of Americans use some form of complementary or integrative health approach. (10) Within cancer care that percentage skyrockets, with some estimates as high as 95% and most surveys at around 50%. (7) Among people with chronic illness, surveys indicate that 70 to 90% use an integrative approach. (3)

Based on a 2020 systematic review, the number one reason people use integrative medicine worldwide is because of the expected benefits, and the second reason is that they are dissatisfied with conventional medicine. (21)

Obviously, for something to be sustainably popular, the user needs to get some benefit. Based on a 2018 review, the scientifically validated benefits of integrative medicine are many and varied, including:

Integrative medicine also excels when it comes to addressing gastrointestinal disorders, (6) musculoskeletal conditions, (4) cardiovascular disease, (25) and stroke. (15)

Perhaps the most well-known randomized controlled clinical trials showing that an integrative approach using diet and lifestyle could reverse cardiovascular disease was conducted by Dean Ornish et al in 1998. (14) Acupuncture, another key integrative treatment modality, has been backed by a significant amount of scientific research. According to a 2019 review, clinical evidence suggests that acupuncture may help treat 96 different health problems including cancer-related symptoms, a variety of different types of pain, and mental health issues such as anxiety and depression. (2)

As with all types of medicine, there are some risks to consider when receiving integrative medicine therapies. Its important to note that some therapies may have side effects or cause adverse effects or injuries, and not all natural therapies are inherently safe. (24) When considering or seeking integrative health care, its important to:

My hope for the future is that integrative medicine will be taught to all health professionals and payment incentives will be revised to support its practice, said Victoria Maizes, MD, the Executive Director of the Andrew Weil Center for Integrative Medicine.

integrative medicine is here to stay and nations who ignore its precious resources would do so at their own economic and health costs, concluded the authors of a 2021 paper on the future of medicine. The authors conclude that integrative medicine must be integrated into medical research, education, and policy. (18) While its true that integrative medicine is here to stay, some would argue that its always been here and we just needed to rediscover it.

In the coming years, there will likely continue to be an increase in usage and an increase in the number of integrative medicine programs offered throughout North America. This is good news for both integrative medicine practitioners and their patients.

If you are interested in exploring integrative medicine, consider consulting with an integrative healthcare practitioner.

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Integrative Medicine – UF Health

Posted: October 16, 2023 at 8:07 pm

"Supporting people on their journey to realizing wholeness

At the UF Health Integrative Medicine Program we treat the whole person mind, body and spirit. We are dedicated to helping you achieve optimal health and well-being in all aspects of life.

Integrative medicine brings together practices once thought of as alternative medicine. Combining those with the latest research and medical technology, fosters the connection between the mind, body and spirit that is often missing in conventional medicine. Integrative medicine bridges the gap between conventional medicine and complementary therapies.

Integrative medicine is an approach to care that puts the patient at the center. It addresses the full range of physical, emotional, mental, social, spiritual and environmental influences that affect a persons health.

The defining principles of integrative medicine are:

At the UF Health Integrative Medicine Program, we are redefining personalized care by addressing all aspects of a patients well-being. Establishing a partnership between patient and practitioner is essential. It helps provide a treatment plan that achieves optimal health.

Integrative medicine is not a replacement for a primary care doctor. Instead, think of an integrative medicine doctor as someone who works with all your health care providers. This helps offer a more comprehensive care plan that utilizes treatments that combine conventional medicine with other therapies. These therapies may include, but are not limited to:

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1st draft of a human ‘pangenome’ published, adding millions of …

Posted: May 17, 2023 at 12:13 am

Scientists have published the first human "pangenome" a full genetic sequence that incorporates genomes from not just one individual, but 47.

These 47 individuals hail from around the globe and thus vastly increase the diversity of the genomes represented in the sequence, compared to the previous full human genome sequence that scientists use as their reference for study. The first human genome sequence was released with some gaps in 2003 and only made "gapless" in 2022. If that first human genome is a simple linear string of genetic code, the new pangenome is a series of branching paths.

The ultimate goal of the Human Pangenome Reference Consortium, which published the first draft of the pangenome on Wednesday (May 10) in the journal Nature (opens in new tab), is to sequence at least 350 individuals from different populations around the world. Although 99.9% of the genome is the same from person to person, there is a lot of diversity found in that final 0.1%.

"Rather than using a single genome sequence as our coordinate system, we should instead have a representation that is based on the genomes of many different people so we can better capture genetic diversity in humans," Melissa Gymrek (opens in new tab), a genetics researcher at the University of California, San Diego, who was not involved in the project, told Live Science.

Related: More than 150 'made-from-scratch' genes are in the human genome. 2 are totally unique to us.

The first full human genome sequence was completed in 2003 by the Human Genome Project and was based on one person's DNA. Later, bits and pieces from about 20 other individuals were added, but 70% of the sequence scientists use to benchmark genetic variation still comes from a single person.

Geneticists use the reference genome as a guide when sequencing pieces of people's genetic codes, Arya Massarat (opens in new tab), a doctoral student in Gymrek's lab who co-authored an editorial about the new research with her in the journal Nature, told Live Science. They match the newly decoded DNA snippets to the reference to figure out how they fit within the genome as a whole. They also use the reference genome as a standard to pinpoint genetic variations different versions of genes that diverge from the reference that might be linked with health conditions.

But with a single reference mostly from one person, scientists have only a limited window of genetic diversity to study.

The first pangenome draft now doubles the number of large genome variants, known as structural variants, that scientists can detect, bringing them up to 18,000. These are places in the genome where large chunks have been deleted, inserted or rearranged. The new draft also adds 119 million new base pairs, meaning the paired "letters" that make up the DNA sequence, and 1,115 new gene duplication mutations to the previous version of the human genome.

"It really is understanding and cataloging these differences between genomes that allow us to understand how cells operate and their biology and how they function, as well as understanding genetic differences and how they contribute to understanding human disease," study co-author Karen Miga (opens in new tab), a geneticist at the University of California, Santa Cruz, said at a press conference held May 9.

The pangenome could help scientists get a better grasp of complex conditions in which genes play an influential role, such as autism, schizophrenia, immune disorders and coronary heart disease, researchers involved with the study said at the press conference.

For example, the Lipoprotein A gene is known to be one of the biggest risk factors for coronary heart disease in African Americans, but the specific genetic changes involved are complex and poorly understood, study co-author Evan Eichler (opens in new tab), a genomics researcher at the University of Washington in Seattle, told reporters. With the pangenome, researchers can now more thoroughly compare the variation in people with heart disease and without, and this could help clarify individuals' risk of heart disease based on what variants of the gene they carry.

Related: As little as 1.5% of our genome is 'uniquely human'

The current pangenome draft used data from participants in the 1000 Genomes Project, which was the first attempt to sequence genomes from a large number of people from around the world. The included participants had agreed for their genetic sequences to be anonymized and included in publicly available databases.

The new study also used advanced sequencing technology called "long-read sequencing," as opposed to the short-read sequencing that came before. Short-read sequencing is what happens when you send your DNA to a company like 23andMe, Eichler said. Researchers read out small segments of DNA and then stitch them together into a whole. This kind of sequencing can capture a decent amount of genetic variation, but there can be poor overlap between each DNA fragment. Long-read sequencing, on the other hand, captures big segments of DNA all at once.

While it's possible to sequence a genome with short-read sequencing for about $500, long-read sequencing is still expensive, costing about $10,000 a genome, Eichler said. The price is coming down, however, and the pangenome team hopes to sequence their next batches of genomes at half that cost or less.

The researchers are working to recruit new participants to continue to fill in diversity gaps in the pangenome, study co-author Eimear Kenny (opens in new tab), a professor of medicine and genetics at the Institute for Genomic Health at Icahn School of Medicine at Mount Sinai in New York City, told reporters. Because genetic information is sensitive and because different rules govern data-sharing and privacy in different countries, this is delicate work. Issues include privacy, informed consent, and the possibility of discrimination based on genetic information, Kenny said.

Already, researchers are uncovering new genetic processes with the draft pangenome. In two papers published in Nature alongside the work, researchers looked at highly repetitive segments of the genome. These segments have traditionally been difficult to study, biochemist Brian McStay (opens in new tab) of the National University of Ireland Galway, told Live Science, because sequencing them via short-read technology makes it hard to understand how they fit together. The long read technology allows for long chunks of these repetitive sequences to be read at once.

The studies found that in one type of repetitive sequence (opens in new tab), known as segmental duplications, there is a larger than expected amount of variation, potentially a mechanism for the long-term evolution of new functions for genes. In another type of repetitive sequence (opens in new tab) that is responsible for building the cellular machines that create new proteins, though, the genome stays remarkably stable. The pangenome allowed researchers to discover a potential mechanism for how these key segments of DNA stay consistent over time.

"This is just the start," McStay said. "There will be a whole lot of new biology that will come out of this."

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A Brief Guide to Genomics – National Human Genome Research Institute

Posted: May 17, 2023 at 12:13 am

Virtually every human ailment has some basis in our genes. Until recently, doctors were able to take the study of genes, or genetics, into consideration only in cases of birth defects and a limited set of other diseases. These were conditions, such as sickle cell anemia, which have very simple, predictable inheritance patterns because each is caused by a change in a single gene.

With the vast trove of data about human DNA generated by the Human Genome Project and other genomic research, scientists and clinicians have more powerful tools to study the role that multiple genetic factors acting together and with the environment play in much more complex diseases. These diseases, such as cancer, diabetes, and cardiovascular disease constitute the majority of health problems in the United States. Genome-based research is already enabling medical researchers to develop improved diagnostics, more effective therapeutic strategies, evidence-based approaches for demonstrating clinical efficacy, and better decision-making tools for patients and providers. Ultimately, it appears inevitable that treatments will be tailored to a patient's particular genomic makeup. Thus, the role of genetics in health care is starting to change profoundly and the first examples of the era of genomic medicine are upon us.

It is important to realize, however, that it often takes considerable time, effort, and funding to move discoveries from the scientific laboratory into the medical clinic. Most new drugs based on genome-based research are estimated to be at least 10 to 15 years away, though recent genome-driven efforts in lipid-lowering therapy have considerably shortened that interval. According to biotechnology experts, it usually takes more than a decade for a company to conduct the kinds of clinical studies needed to receive approval from the Food and Drug Administration.

Screening and diagnostic tests, however, are here. Rapid progress is also being made in the emerging field of pharmacogenomics, which involves using information about a patient's genetic make-up to better tailor drug therapy to their individual needs.

Clearly, genetics remains just one of several factors that contribute to people's risk of developing most common diseases. Diet, lifestyle, and environmental exposures also come into play for many conditions, including many types of cancer. Still, a deeper understanding of genetics will shed light on more than just hereditary risks by revealing the basic components of cells and, ultimately, explaining how all the various elements work together to affect the human body in both health and disease.

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Houston Integrative Medicine

Posted: May 17, 2023 at 12:13 am

First, we strongly believe in the value of preventative care, a concept grounded in traditional Chinese medicine. Brian Carter's Pulse of Oriental Medicine states the traditional Chinese doctor's job was to keep the village from getting sick and they in return would make sure his needs were met. Once they became sick, they were unable to take care of the doctor, therefore, it only made sense for him to keep them well. Our role is to keep you well before any signs of disease surface. By keeping mind, body and spirit in balance, maintaining appropriate nutrient levels and exercising a positive lifestyle, one is proactively taking care of themselves.

Second, we believe in natural healing. The body has an innate ability to heal itself, we simply assist you on your journey towards wellness. While western medication is effective at treating many illnesses, it can also act as a double-edged sword; the chemicals in pills and other drugs can have many potentially harmful side effects. Our doctors take a comprehensive look at your medical concerns and prescribe the healthiest solution that is individualized for your needs.

Third, the Center for Primary Care and Integrative Medicine seeks to reduce the increasingly prevalent abuse of narcotics. The United States consumes 60% of the world's narcotics and 99% of global Norco, and these are increasingly prescribed unnecessarily. This has adverse effects on the patient's body. More than 96,000 Americans and 4500 Texans died of drug overdoses in 2020 per CDC data. We should reduce their use as much as possible without compromising pain control. Today, more and more people are turning to natural methods of healing. The Center for Primary Care and Integrative Medicine incorporates the best of conventional and alternative medicine to provide the highest quality of care possible.

While preventing chronic disease has been our main focus of practice, we emphasize the importance of helping patients who already suffer from a variety of chronic diseases actively recover. In addition to regular cardiopulmonary rehab, we offer Taichi, massage, and acupuncture to help patients from a variety of chronic conditions, e.g., chronic Congestive Heart Failure, COPD, Parkinsons disease, etc., improve functional status. Studies have shown that acupuncture and Taichi can favorably affect heart rate variability and thus decrease post-myocardial infarct mortality. Acupuncture as adjunctive therapy can be used to alleviate chronic stable angina (JAMA intern Med. 2019;179 (10):1388-1397). Taichi-based cardiac rehabilitation was associated with an increase in peak oxygen consumption, a marker of functional capacity, in patients with recent MI. Acupuncture has been shown to reduce interleukin-17 (IL-17, inflammation marker) in asthmatic patients and increase 6 minute walking distance and quality of life in COPD patients. Recent studies, published in CHEST 2018; 153 (5): 116-1124, has shown that Tai Chi is equivalent to pulmonary rehab in improving functional status in COPD patients. Tai chi training has been shown to reduce balance impairments in patients with mild -to-moderate Parkinsons disease, with additional benefits of improved functional capacity and reduced falls (N Engl J Med 2012;366:511-9). Preliminary study has shown that Scalp acupuncture effectively slows down disease progress in Parkinsons disease patients and improve quality of life.

Last, but not least, we strive to reduce the cost of medicine for both individuals and the nation. Health care costs have been rising for several years and remains a focus of worldwide discussion. National health expenditures have doubled over the past decade from $1.3 trillion in 2000 to $2.6 trillion in 2010. It exceeded $ 4 trillion in 2020 according to Center for Medicare & Medicaid services (CMS). Total health care expenditures grew at an annual rate of 4.4 percent in 2008, outpacing inflation and the growth in national income. Indeed, we are a nation providing the best "sick" care. If we looked at replacing "sick" care with preventative medicine, we would be a healthier and wealthier nation. Spending on new medical technology and prescription drugs has been cited as a leading contributor to the increase in overall health. The Center for Primary Care and Integrative Medicine focuses on prevention and treatment of chronic diseases such as hypertension, diabetes, obesity, and chronic pain. Integrative medicine has been known to be highly effective in the treatment of such illnesses. In addition,the Center also gives consults to patients who want to learn taichi and yoga to improve well being.

Center for primary care and Integrative Medicine has also been actively collaborating with world renowned institutes to explore mechanisms underlying the effects of acupuncture, Ethnopharmacology, and the application of traditional Chinese Medicine in health regimen.

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What is integrative medicine (IM)? – Medical News Today

Posted: May 17, 2023 at 12:13 am

Integrative medicine (IM) is an approach that combines conventional medicine with complementary treatments. The aim of IM is to treat the whole person, not just a health problem.

Because IM is holistic, it can target the behavioral, social, and environmental aspects of a persons life as well as help treat the underlying health issue.

Many people are requesting more complementary therapies as part of their treatment plans, especially in certain health areas, such as cancer. That said, it is important to note that people should not replace their prescribed clinical treatments with complementary approaches alone, as this could lead to worse health outcomes.

Instead, people should discuss their current therapies with a doctor who can advise on the best course of treatment.

Read on to learn more about IM, including the risks, the benefits, and some of the conditions it may be useful for.

IM is a whole-person treatment plan that aims to treat the body, mind, and spirit. It specifically includes and coordinates the use of complementary therapies alongside conventional medicine.

Usually, a complementary therapy practitioner will suggest a combination of treatments to improve a persons well-being. For example, they may suggest that a person practices yoga to reduce stress but also recommend that they get in touch with an acupuncturist.

Practitioners tend to group complementary therapies into three key areas: nutritional, psychological, and physical.

Nutritional complementary therapies include products such as herbs, vitamin and mineral supplements, and probiotics. Supplements come in many forms, such as capsules, liquids, and powders. A person may also receive a specific diet plan.

A person should always speak with a doctor before taking any supplements in addition to their prescribed treatment. Doing so can cause certain interactions. For example, vitamin K can reduce the effectiveness of warfarin, which is a blood-thinning medication.

Psychological forms of complementary therapy aim to settle the mind and reduce stress. These therapies include:

There is a lot of overlap between mind and body practices. For example, although yoga and tai chi are physical practices, they also promote psychological well-being.

Learn more about types of meditation here.

Physical approaches to complementary health may include some form of muscle manipulation, such as massage. People may also receive treatment from a chiropractor, who can manipulate the spine to reduce pain or alleviate other health problems.

Alternatively, acupuncture is a physical treatment during which a practitioner inserts fine needles through the skin to stimulate specific pressure points.

Physical therapies that a person can try on their own or as part of a class include yoga and tai chi.

The use of integrative care is growing, especially in specialist cancer centers, where more people are requesting complementary approaches in addition to clinical treatments, such as chemotherapy.

In fact, one 2017 systemic review found that 45 National Cancer Institute treatment centers had increased the number of complementary treatments they offered on their websites over the course of 7 years, from 2009 to 2016. The most popular therapies included acupuncture, meditation, and yoga.

When a healthcare professional introduces complementary therapies as part of a persons treatment plan, the goal is usually to alleviate some side effects of conventional medicine.

For example, the authors of a 2018 meta-analysis note that acupuncture seems particularly effective at reducing fatigue in people with breast cancer who receive anticancer treatment.

However, an additional 2019 systematic review of studies that investigated the relationship between complementary therapies and cancer states that more robust study designs are necessary to fully understand the effectiveness of complementary therapies in an oncology environment.

Another area that may benefit from complementary therapy is fertility. One 2018 review suggests that females who practice Hatha yoga alongside other mind and body therapies may feel less stressed and anxious during in vitro fertilization treatment. Their psychosocial health may also improve.

Introducing IM may have some benefits. For example, a 2018 review notes that, overall, IM helps people deal with difficult illnesses and reduces their distress.

Furthermore, in some instances, IM may actually improve health outcomes. For example, a 2018 study based in South Korea found that when people received IM after experiencing a stroke, they had stronger survival rates at 3 and 12 months than those who received conventional medicine alone.

Although integrative care was more expensive, it prevented future hospital admissions, which can help hospitals save money in the long run.

People should be aware of the risks associated with some complementary approaches when including them in their treatment regimen.

The Food and Drug Administration (FDA) approves all conventional medications before manufacturers can sell them, but manufacturers of supplements do not need FDA approval to put their products on the market.

Additionally, some supplements can interact with some medications. This can increase the risk of complications if a person is also taking another medication.

It is also important that people do not view supplements and other herbal remedies as a cure or a replacement for conventional medication. If a manufacturer promotes its supplement as a cure, the product is likely unsafe.

Study design is also an important point that people should think about when researching the health benefits of some complementary therapies. Complementary health studies do not usually have robust study designs that other researchers can replicate, which means that the findings and conclusions could be inaccurate.

That said, the National Center for Complementary and Integrative Health is funding more studies to further investigate the health benefits of complementary therapies and how healthcare professionals can use them in addition to conventional medicine.

IM and alternative medicine are two terms that describe treatment that sits outside of conventional medical care.

If a person uses a nonconventional treatment option in a coordinated manner alongside conventional medicine, the practice is IM.

If a person uses a nonconventional treatment option instead of conventional medicine, the practice is alternative medicine.

Integrative medicine (IM) includes both complementary and conventional treatment approaches and specifically coordinates the use of the two as part of a holistic treatment plan.

Some benefits of IM include reducing distress and helping people process living with a difficult illness. Some healthcare professionals are expanding the use of IM, especially in the treatment of cancer.

Although researchers are taking a proactive attitude toward investigating the possible benefits of IM, studies that support complementary approaches often have design flaws, which means that their conclusions could be inaccurate.

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A Look Inside Stem Cells Helps Create Personalized Regenerative …

Posted: May 17, 2023 at 12:12 am

In two papers, researchers examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.

Nicholas Zhang, Georgia Tech Ph.D. candidate 

Organelles the bits and pieces of RNA and protein within a cell play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy. Organelle diversity in cells not only exists between cell types but also individual cells. Studying these differences helps researchers better understand cell function, leading to improved therapeutics to treat various diseases.

In two papers out of the lab of Ahmet F. Coskun, a Bernie Marcus Early Career professor in the Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, researchers examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.

We are studying the placement of organelles within cells and how they communicate to help better treat disease, said Coskun. Our recent work proposes the use of an intracellular toolkit to map organelle bio-geography in stem cells that could lead to more precise therapies.

Creating the Subcellular Omics Toolkit

The first study published in Scientific Reports, a Nature portfolio journal looked at mesenchymal stem cells (MSCs) that have historically offered promising treatments for repairing defective cells or modulating the immune response in patients. In a series of experiments, the researchers were able to create a data-driven, single-cell approach through rapid subcellular proteomic imaging that enabled personalized stem cell therapeutics.

The researchers then implemented a rapid multiplexed immunofluorescence technique in which they used antibodies designed to target specific organelles. By fluorescing antibodies, they tracked wavelengths and signals to compile images of many different cells, creating maps. These maps then enabled researchers to see the spatial organization of organelle contacts and geographical spread in similar cells to determine which cell types would best treat various diseases.

Usually, the stem cells are used to repair defective cells or treat immune diseases, but our micro-study of these specific cells showed just how different they can be from one another, said Coskun. This proved that patient treatment population and customized isolation of the stem cells identities and their bioenergetic organelle function should be considered when selecting the tissue source. In other words, in treating a specific disease, it might be better to harvest the same type of cell from different locations depending on the patients needs.

RNA-RNA Proximity Matters

In the next study published this week in Cell Reports Methods, the researchers took the toolkit a step further, studying the spatial organization of multiple neighboring RNA molecules in single cells, which are important to cellular function. The researchers evolved the tool by combining machine learning and spatial transcriptomics. They found that analyzing the variations of gene proximity for classification of cell types was more accurate that analyzing gene expression only.

The physical interactions between molecules create life; therefore, the physical locations and proximity of these molecules play important roles, said Coskun. We created an intracellular toolkit of subcellular gene neighborhood networks in each cell's different geographical parts to take a closer look at this.

The experiment consisted of two parts: the development of computational methods and experiments at the lab bench. The researchers examined published datasets and an algorithm to group RNA molecules based on their physical location. This nearest neighbor algorithm helped determine gene groupings. On the bench, researchers then labeled RNA molecules with fluorescents to easily locate them in single cells. They then uncovered many features from the distribution of RNA molecules, such as how genes are likely to be in similar subcellular locations.

Cell therapy requires many cells with highly similar phenotypes, and if there are subtypes of unknown cells in therapeutic cells, researchers cannot predict the behavior of these cells once injected into patients. With these tools, more cells of the same type can be identified, and distinct stem cell subsets with uncommon gene programs can be isolated.

We are expanding the toolkit for the subcellular spatial organization of molecules a Swiss Army Knife for the subcellular spatial omics field, if you will, said Coskun. The goal is to measure, quantify, and model multiple independent but also interrelated molecular events in each cell with multiple functionalities. The end purpose is to define a cells function that can achieve high energy, Lego-like modular gene neighborhood networks and diverse cellular decisions.

This research is funded by Regenerative Engineering and Medicine at Georgia Tech, as well as the NSF Engineering Research Center for Cell Manufacturing Technologies (CMaT).

CITATION: Venkatesan, M., Zhang, N., Marteau, B., Yajima, Y., Ortiz De Zarate Garcia, N., Fang, Z., Hu, T., Cai, S., Ford, A. Olszewski, H., Borst, A., and Coskun, A. F. Spatial subcellular organelle networks in single cells.Scientific Reports13, 5374 (2023). doi.org/10.1038/s41598-023-32474-y

CITATION: Fang, Z., Ford, A., Hu, T., Zhang, N., Mantalaris, A., Coskun, A.F. Subcellular spatially resolved gene neighborhood networks in single cells. Cell Reports Methods. May 12, 2023. doi.org/10.1016/j.crmeth.2023.100476

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Artificial sweeteners dont aid weight loss, may increase diabetes, heart disease risk, says WHO – ThePrint

Posted: May 17, 2023 at 12:07 am

  1. Artificial sweeteners dont aid weight loss, may increase diabetes, heart disease risk, says WHO  ThePrint
  2. World Health Organization warns nonsugar sweeteners may increase risk of diabetes and heart disease  MarketWatch
  3. WHO: Artificial sweeteners linked to diabetes, death  POLITICO Europe

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How Does Gene Therapy Work? Types, Uses, Safety – Healthline

Posted: May 9, 2023 at 12:11 am

Gene therapy may have the potential to fix or replace genetic mutations, which are changes in your DNA that affect how your body works.

Doctors use gene therapy, also called gene editing to directly alter your genes.

This approach may help treat diseases caused by a single mutation, such as beta-thalassemia or spinal muscular atrophy (SMA). Gene editing may also help treat certain cancers.

Gene editing tools such as CRISPR-Cas9 are very new and are rapidly changing. Researchers continue to study their full potential along with any risks they may pose.

Heres what experts know so far about gene therapy.

Genes are small segments of DNA that instruct your cells to make certain proteins when specific conditions are met.

Mutated genes, on the other hand, may cause your cells to make too much or too little of the necessary protein. Even small changes can have a domino effect across your body just as tiny changes in computer code can affect an entire program.

Gene therapy can address this issue by:

Scientists dont have tweezers small enough to edit your DNA by hand. Instead, they recruit a surprising ally to work on their behalf: viruses.

Typically, a virus would enter your cells and alter your DNA to create more copies of itself. But scientists can switch out this programming with their own, hijacking the virus to heal instead of harm. These vectors, as theyre called, dont have the parts they need to cause disease, so they cant make you sick the way a regular virus could.

There are two types of gene therapy:

Each type has its own benefits:

Gene therapy is different from genetic engineering, which means changing otherwise healthy DNA for the purpose of enhancing specific traits. Hypothetically, genetic engineering could potentially reduce a childs risk of certain diseases or change the color of their eyes. But the practice remains highly controversial since it hovers very close to eugenics.

Gene therapy may be used to treat a variety of genetic conditions, including:

When the RPE65 gene in your retinas doesnt work, your eyeballs cant convert light to electrical signals.

The gene therapy Luxturna, approved by the Food and Drug Administration (FDA) in 2017, can deliver a functional replacement of the RPE64 gene to your retinal cells.

The FDA-approved Hemgenix can treat the bleeding disorder hemophilia B. The viral vector instructs your liver cells to create more of the factor IX protein, which helps your blood clot.

Meanwhile, the gene therapy Zynteglo, approved by the FDA in 2022, treats beta-thalassemia by giving your bone marrow stem cells correct instructions for creating hemoglobin.

This blood disorder can lower the oxygen in your body because it decreases your bodys hemoglobin production.

In infantile-onset SMA, an infants body cant make enough of the survival of motor neuron (SMN) proteins necessary to build and repair motor neurons. Without these neurons, infants gradually lose their ability to move and breathe.

The gene therapy Zolgensma, approved by the FDA in 2019, replaces faulty SMN1 genes in an infants motor cells with genes that can create enough SMN proteins.

Your ABCD1 gene produces an enzyme that breaks down fatty acids in your brain. If you have cerebral adrenoleukodystrophy, this gene is either broken or missing.

Skysona, FDA approved as of 2022, delivers a functional ABCD1 gene so that fatty acids dont build up and cause brain damage.

The FDA has approved gene therapies to treat multiple types of cancer, such as non-Hodgkins lymphoma and multiple myeloma.

Most cancer gene therapies work indirectly by inserting new genes into a powerful antibody called a T cell. Your changed T cells can then latch on to cancerous cells and eliminate them, similar to how they attack viruses.

The therapy Adstiladrin, approved by the FDA in 2022, can treat nonmuscle-invasive bladder cancer by altering the DNA in your bladder cells themselves.

Some people considering gene therapy may feel uneasy about putting viruses in their body.

Keep in mind, though, that gene therapies undergo extensive testing before approval. The viruses in gene therapies are also fixed so they cant replicate similar to many vaccines.

That said, gene therapies may pose other risks:

Despite these issues, experts generally believe gene therapy offers more benefits than risks.

Most of the conditions treated with gene therapy are life threatening. The dangers of leaving them untreated often outweigh the risks of potential side effects.

Gene therapy does come with a few drawbacks that keep it from becoming a widespread treatment.

Gene therapy can only target certain mutations. This means it may not work for everyone with a specific condition.

For example, two people may have inherited vision loss. Currently, gene therapy can only treat vision loss caused by the RPE64 mutation.

Because gene therapy research is so new, experts do extensive safety testing before introducing their treatments to the public. It can take years to get FDA approval for each new therapy.

As you might imagine, gene therapies are expensive to manufacture and administer. This not only affects funding for clinical trials but also the price of the drug.

For example, the gene therapy Zolgensma is the most expensive drug in the United States at $2.1 million per dose. Even with insurance, that kind of price tag remains out of reach for the average American.

Scientists are trying to find ways to make the development process safer, cheaper, and more efficient so more people can access gene therapy.

Gene therapy works to treat several different genetic diseases by editing the mutations that cause them. As researchers further refine and expand this technology, they may find even more conditions that could be treated with it.

Experts are also continuing to explore options to make gene therapy more affordable so people who need these treatments have an easier time getting them.

Emily Swaim is a freelance health writer and editor who specializes in psychology. She has a BA in English from Kenyon College and an MFA in writing from California College of the Arts. In 2021, she received her Board of Editors in Life Sciences (BELS) certification. You can find more of her work on GoodTherapy, Verywell, Investopedia, Vox, and Insider. Find her on Twitter and LinkedIn.

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How Does Gene Therapy Work? Types, Uses, Safety - Healthline

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Revolution Medicines Reports First Quarter 2023 Financial Results and Update on Corporate Progress

Posted: May 9, 2023 at 12:10 am

First Wave of Investigational RAS(ON) Inhibitors – RMC-6236 (RASMULTI), RMC-6291 (KRASG12C) and RMC-9805 (KRASG12D) – progressing on plan

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Revolution Medicines Reports First Quarter 2023 Financial Results and Update on Corporate Progress

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