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CLINUVEL to Trial Innovative Drug in Stroke

Posted: October 28, 2020 at 3:54 am

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Sanofi and GSK to support COVAX with 200 million doses of adjuvanted, recombinant protein-based COVID-19 vaccine

Posted: October 28, 2020 at 3:54 am

Sanofi and GSK to support COVAX with 200 million doses of adjuvanted, recombinant protein-based COVID-19 vaccine

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Basilea announces Clinical Trial Collaboration and Supply Agreement with Eli Lilly and Company for ramucirumab in the ongoing FIDES-03 study with…

Posted: October 28, 2020 at 3:54 am

Basel, Switzerland, October 28, 2020

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Novartis announces collaboration with Molecular Partners to develop two DARPin® therapies designed for potential use against COVID-19

Posted: October 28, 2020 at 3:54 am

Basel, October 28, 2020 — Novartis and Molecular Partners AG today announced a collaboration in the form of an option and license agreement to develop, manufacture and commercialize Molecular Partners’ anti-COVID-19 DARPin® program, consisting of two therapeutic candidates, MP0420 and MP0423. The collaboration aims to leverage Molecular Partners’ proprietary DARPin® technologies and Novartis broad expertise in global drug development, regulatory affairs, manufacturing and commercialization to rapidly advance the program in keeping with the unprecedented global urgency created by the pandemic.

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Battle of the sexes – Golf – Albany Times Union

Posted: October 28, 2020 at 3:54 am

Of the many reasons you should consider joining a golf club, one is the opportunity to play in tournaments with people you know, carrying handicaps you can trust. These tournaments take many forms but at my course, one of the most loved formats, the tournament that best cements relationships between male and female members, is the Ryder Cup competition.

About 25 years ago our PGA Professional suggested a male/female tournament that pitted the women against the men. The format would be 16 of each gender playing four nine hole events with each of the first three (alternate shot, better ball of partners and two person scramble) worth one point per two person match, then 16 single matches on the fourth nine worth a point each.

There would be no prizes, no money in the Golf Shop just bragging rights.

From the get-go both genders realized the importance of the tournament. Each male strives to establish his place as the Silver Backed Alpha Male (SBAM), while the women are more team oriented. Thinking about it, there is a startling parallel in each teams attitude to the real Ryder Cup the men are the individualistic American squad while the European team attitude prevailed with the women, who start each tournament by huddling, arms over each others shoulders and giving a rah-rah cheer bone chilling if you are a guy competitor.

The first year the women thoughtfully provided snacks and shots of scotch before the competition began; the food out of the kindness of their hearts, the booze a transparent tactic to befuddle the guys. Thus began the tradition of giving tee prizes to each other every year before the first ball was airborne. What this evolved into might be considered by outsiders to be misogyny and misandry, even rampant sexism, but all involved knows it for what it is great fun.

Plans for the tee gift are made weeks in advance, as each team tries to out-humiliate the other. It started out fairly benign the second year with the guys presenting the gals with personalized certificates for each woman, proclaiming their second place finish before the games began and the eventually victorious women returning them to the men at the end of the tournament, their name scratched out and replaced with their opponents moniker. The stage was set.

The women took first place four of the first five years, rendering us SBAMs emasculated, especially the year we received two pink golf balls in a small jock strap as our tee prize. We countered with retroactive trophies the next year bowling trophies, the bowler figure on top cut off and replaced with a Ryder cup, except the cup was a glued-on measuring cup. Other prizes included aprons for the women proclaiming their second place finish and a white belt for the men, printed with pictures of all of the SBAMs and the statement 2019 BSCC Women Belt Men. Which they then proceeded to do.

Then there was the lunch box with a faux stuffed crow inside; a bottle of wine relabeled as Chateau de Feat out of the Love Canal Vineyard, sporting a picture of toxic waste; Cracker Jack boxes that had been opened from the bottom and resealed after removing the original prize and replacing it with a ball marker labeled LOSER; a six pack sampler of beer relabeled with brands such as Boars Butt Beer and 17th Hole Pond Scum Lager.

One year the SBAMs got a case of Wheaties from the local supermarket, unopened, still in the original case, strapping and all. We carefully removed the strapping, put a redone front panel over each of the original boxes, with pictures of all 16 male players and slogans such as 100% whole wheat replaced with 100% Testosterone. It looked exactly like the original front panel and as we broke the strapping and opened the case to distribute the Wheaties boxes to the women, one of them quipped, I hope it has our pictures on it. Priceless.

Next years Ryder Cup will be held the week after that other one in Europe. Thirty-two women and men will meet on a Fall Saturday morning in the gazebo and determine the pairings amid atrocious trash talking before going out to battle. I cant wait.

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New virtual clinic aims to provide accessible, inclusive health care to LGBTQIA+ North Carolinians – Yes! Weekly

Posted: October 28, 2020 at 3:54 am

With the recent confirmation of Amy Coney Barrett to the United States Supreme Court on Monday night, many Americans will most likely lose their access to affordable health care in the near future. And this is particularly disturbing to North Carolinians because, for almost a decade, Republican leadership in the states legislature has refused to expand Medicaid, despite support from voters on both parties. The Center for American Progress, an independent, nonpartisan policy institute, and NORC at the University of Chicago conducted a survey with 1,528 LGBTQIA+ identifying individuals in June.

In states that have not expanded Medicaid, the rate of LGBTQIA+ adults who are uninsured is 20 percent, the results state, adding that LGBTQIA+ adults making less than $45,000 a year are the ones most prominently affected. According to this survey, transgender folks and people with disabilities bear the brunt of the high cost of health care, as 51% of transgender individuals and 40% of people with disabilities who needed medical care postponed it due to cost, and 40% of transgender individuals and 30% of people with disabilities postponed preventative screenings due to cost.

A Greensboro-based virtual clinic with a focus on LGBTQ health hopes to support those living in the margins of society by providing virtual health care services to anyone living in North Carolina. Founded by Chief Operating Officer Jamie Clarke and Chief Medical Officer Dr. Subrata John Guha, the LGBTQ Clinic was conceptualized specifically with the health care needs of LGBTQIA+ people in mind.

If you have a phone, iPad, or computer, you can come see us, Guha said. You dont have to go anywhere just be seen where you are comfortable, and take a proactive approach for your health.

According to Clark and Guhas research, there are approximately 420,000 people that identify as LGBTQIA+ in North Carolina, and of those, 30,000 identify specifically as transgender. Clarke is one of those 30,000. Unfortunately, Clarke knows all too well the barriers that other trans people face when seeking health care.

I had a lot of problems getting comfortable, comprehensive medical care, she said. Not just about [Hormone Replacement Therapy] or sexual health, but about Jamie as a whole person, which encompasses all of those things and my day-to-day medical needs.

She said that the LGBTQIA+ community, as a whole, are not very trusting of doctors. As a transgender woman, she has experienced first-hand what that is like to be treated differently because of her gender identity. At age 35, Clarke decided that she wanted to begin transitioning by starting HRT, so like any other patient, she asked her doctor for more information.

I was dealing with a local doctor and asked to have my hormone levels checked, as I was getting bloodwork done anyway, she said. And they were like, well, why would you want to do that? And I was like, so I can start HRT, and she said, Oh, I am not comfortable doing that.

This experience led Clarke to switch to Dr. Guha. During her interview with him, she felt comfortable enough to ask about starting HRT because he was honest, straightforward, and extremely easy to talk to.

Clarke said when she told him that she was interested in starting HRT, he told her that he wasnt too familiar with it, so he had to do some more research to make sure he was doing it properly.

As we got to know each other, I was explaining to him that sometimes, I was at the point where I wanted to go online and figure out how to do it myself. But he was like thats probably not safe, Clarke said. And there are a whole lot of people that are in that exact boat. So, we are trying to take the stigma out of LGBTQIA+ health.

With The LGBTQ Clinic, Clarke and Guha said they are trying to create a movement toward community-based, equalized health care by building relationships with clients in a convenient and accessible format.

In the telemedicine space, typically what you get is a five-minute visit, sometimes not even by video but as a phone call, Clarke said. Our visits are 15 minutes long, and we strongly encourage getting to know your doctor, and vice versa, because you always get the same care provider.

Clarke described the LGBTQ Clinic as everything one would expect at a visit to their regular health care provider, only virtually.

One of our marketing specialists was like, think about it as going to the doctors office, not getting deadnamed, and you dont have to sit on the crunchy paper in a germ pool, Clarke said.

Guha explained that the LGBTQ Clinic could basically replace ones primary care doctor because it is all-encompassing and that everyone, not just LGBTQIA+ people, could receive health care services.

I can write a virtual prescription to your pharmacist, any pharmacist we are basically like walking into your doctors office but all virtual, Guha said. We cant administer shots, but if it can be self-administered, then I can prescribe it, and you can pick it up.

However, Guha said he makes sure he is thorough with each patient he sees.

When someone comes in, I dont just write a prescription for testosterone, he said. I want that lab work, and I would want to see the patient again after the lab work [results came back] to go over it and then provide the prescription.

The LGBTQ Clinic isnt Guhas first foray into providing fast and accessible health care services to people. Guha said he helped start FastMed back in the ancient ages of 2010, but sold out of it in 2014-2015 after the business was acquired by a venture capitalist. As a heterosexual, cisgender man, Guha said he believes that everyone should have the same access to health care and be treated equally, which is why he was more than happy to help start this clinic.

Guha takes pride in his informed approach to LGBTQIA+ health, as he follows the guidelines put out by the University of California at San Francisco and its Department of Internal Medicines sub-department, which is specifically tailored for the LGBTQIA+ community.

In the last five years, this premier medical center started putting out clinical protocols that established guidelines and state of the art, the scope of practice protocols, he noted.

Launching the LGBTQ Clinic hasnt been easy but has been a labor of love for both Clarke and Guha.

We are really excited about it, she said. Being in Greensboro, and with it being such a large college town, the need is absolutely there. One of the hardest things we are having problems with is trying to have conversations with influencers or people that can get the message out for us. I dont want to be a sponsored ad; I want to be a trusted resource.

Clarke said North Carolinas 2016 controversial Bathroom Bill was a big part of their discussion, and it was a driving factor as to why we would create this clinic specifically.

We dont have time for the noise, Clarke said of the recent politicizing of health care. We just want to provide quality health care to as many people that need it as we can...Its also about bringing some respectability to a state like North Carolina, where there is a lot of uncertainty about this particular issue.

Whoever is elected president in November, we will still be here, she added.

Clarke said each 15-minute virtual session costs $78 per visit, which she said is cheaper than the $150 that is usually charged by the local larger medical centers.

We are looking to do a subscription plan, but because we are so new, we are still testing the market, Guha said, adding that The LGBTQ Clinic will soon accept insurance coverage from Blue Cross Blue Shield of North Carolina, Cigna, United Care, and others.

We are actively pursuing the credentialing process, and its just a waiting game, Clarke said.

I am guessing in the next 30-60 days, and the reason why it is taking so long, as you probably already know, is because of COVID, Guha added.

Presently, there are two doctors (including Guha) and one nurse practitioner on staff at The LGBTQ Clinic. Clarke said she is looking for support from local LBGTQIA+ community leaders but makes it clear that they are not trying to buy their way into the community. Clarke and Guha said they arent in the business of just making a quick buck; they want to establish the LGBTQ Clinic as a long-term resource.

Health care should not be any different or any less quality because you are in the LGBTQ community, she said. We are trying to provide and be a voice to the movement. With a 30-veteran of the health care industry to say that your health care is no different or more valuable than anyone elses, that is the real distinction here.

For more information, visit the website and follow The LGBTQ Clinic on social media (Instagram and Facebook, @lgbtq.clinic)

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Sorkin’s Blast From The Past: The Trial Of the Chicago 7 – Forbes

Posted: October 28, 2020 at 3:54 am

The Trial of the Chicago 7 revisits a flashpoint in American history as written and directed by Aaron Sorkin and now available on Netflix.

Poster for The Trial of the Chicago 7

Sorkin is a master of the courtroom drama whose films often build to one climatic speech. Sorkins work includes the screenplays for A Few Good Men (You cant handle the truth), Malice (I am God!), The American President (I am the President), as well as The Social Network (Wheres your Facebook?) and his recent directorial debut Mollys Game (Because its my name!).Sorkin is also justly praised for The West Wing, where Walk and Talk shots became a signature Sorkin feature.

Sorkin does his best work when he finds a way to make the central issue personal when he finds a story with no obvious connection to him that nonetheless mirrors his own deepest beliefs or serves as the forum to relitigate his own private personal emotional dramas, arguments and wounds.

In 1968, The Democratic National Convention was held in Chicago. Following the murders that Spring of Martin Luther King, Jr., and Robert F. Kennedy, the Convention was seen as a referendum on the Vietnam War. Or at least protesters wanted it to become that. Three different protest groups, the Students for a Democratic Society (SDS), the Youth International Party (Yippies), and the National Mobilization Committee to End the War in Vietnam (MOBE), all called upon their supporters to come to Chicago to protest at the convention.

The Convention became the scene of violent riots, with Chicago Police beating protesters. Hubert Humphrey received the Democratic nomination but lost the election to Richard Nixon who campaigned on a Law and Order platform. Once Nixon was in office, his Attorney General John Mitchell ordered the prosecution of the protest leaders: Rennie Davis and Tom Hayden of the SDS, Abbie Hoffman and Jerry Rubin of the Yippies, Dave Dellinger of the Mobilization Committee as well as two other protesters. Bobby Seale, chairman of the Black Panther Party was also indicted.

Judge Julius Hoffman was chosen to hear the case. William Kunstler and Leonard Weinglass were the defense attorneys for the defendants other than Bobby Seale whose lawyer could not make it to Court. Seale was unrepresented and Judge Hoffman would not allow Seale to represent himself. Eventually after Hoffman ordered Seale bound and gagged to end his outbursts, a mistrial was declared for Seale, who left the case.

Sacha Baron Cohen as Abbie Hoffman with Jeremy Strong as Jerry Rubin in Netflix's The Trial of the ... [+] Chicago 7

Sorkin sets up conflict among the characters as well as against the Judge and Nixons Justice Department. In Sorkins telling (which is based on the actual trial transcripts), Tom Hayden (Eddie Redmayne) and Rennie Davis (Alex Sharp) are political activists hoping to change the system in many ways more establishment and more respectful of the judicial system than Abbie Hoffman (Sascha Baron Cohen) and Jerry Rubin (Jeremy Strong), who are set up initially as attention hungry anarchists who care more about publicizing themselves than ending the war; and Dave Dellinger, who is the adult in the room, a pacificist believer in non-violence who wants to bring about the end of the war in Vietnam. There appears to be hostility between Hayden and Hoffman as to how best to win their case or, for that matter, how best to end the Vietnam War.

Judge Julius Hoffman (Frank Langella) comes off as biased, short-tempered, and perhaps senile. William Kunstler (Mark Rylance) appears as earnest, sincere, and mostly trying to keep the peace among his defendants and find a way to make their case in court.

Sorkins magic act is such that after setting up Hayden as the voice of reason for most of the movie, it is Hoffman who saves the day. Likewise, Sacha Baron Cohen who steals the movie in what is his best dramatic performance to date. Sorkins reveal is that Hoffman is the one who sees the clearest, who early on understands that this is a political trial, and that the case and its impact would be made both in court and outside among the protesters and the press. On the witness stand, it is Hoffman who gives the answers that best frame the movie. And true to Sorkins predilections, it is Hoffmans explanation of Haydens grammatical vagaries upon which the movie hangs (Its true, I swear!).

All in all, Sorkin makes a crackling drama out of what was a lengthy and laborious trial and does so in a way that has great resonance to today and the recent Black Lives Matter protestsand, more generally, concerning the Trump administration.

So my review, in short: Watch the Trial of the Chicago 7 youll learn lots and its worth watching for Sacha Baron Cohens performance.

Now, putting that all aside, when a narrative piece of entertainment is fashioned about real people there is always that question of how true the performances and characterizations are to the actual people. Certainly the actors can study film and tape, but most of them never had the opportunity to see these people, in person, in their prime. I did.

Over the course of time, I had the chance to hear speak many of the people portrayed in this movie including Abbie Hoffman, Jerry Rubin, Dave Dellinger, Rennie Davis, Tom Hayden and William Kunstler. And although Sorkin is faithful to the trial transcript, the personalities of the characters were different than what we see onscreen. So, for example, Ryland plays Kunstler with a certain modesty, reticence and seriousness of purpose. Kunstler was more of a firebrand, more passionate, more full of himself. Hayden was like his screen character, aggressive and somewhat professorial, but more blue collar in affect than Redmayne. Rennie Davis was more commanding when he spoke. Dave Dellinger was about right, although he had more gravitas. Jerry Rubin was a bright light, high energy and fun (Sorkin diminishes him in this telling). And as for Abbie, Sacha Baron plays him as a stand-up comic, but a very intelligent one (Closer I would say to Cohen himself than Hoffman).I would say Abbie had more testosterone. He was more combative, more provocative. With Abbie there was always a level of engagement and aggression amid his brilliance that is not evident in the screen performance.

Some 40 years ago, youthful political organizers were put on trial by a US government set on curtailing their rights and punishing them for speaking out in what was more political spectacle than legal proceeding. If the passage of time has sought to blunt that memory, and to forget the names of Abbie Hoffman, Jerry Rubin, Tom Hayden, Rennie Davis, Dave Dellinger, Bobby Seale and Bill Kunstler, Aaron Sorkin has done them the tribute of giving them new life in his very watchable and superbly acted film, The Trial of the Chicago 7.

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Rogel team receives $11.2M to leverage the microbiome against GVHD – Newswise

Posted: October 28, 2020 at 3:51 am

For immediate release

Newswise ANN ARBOR, Michigan A team of researchers from the Rogel Cancer Center received an $11.2 million grant from the National Heart, Lung and Blood Institute to study how to use the microbiome to limit complications of stem cell transplants for blood cancers and other diseases.

Hematopoietic cell transplants using donor cells can be a lifesaving treatment. But graft-versus-host disease, is a common serious side effect that can limit its use.

Researchers who have been exploring the role the microbiome and host-metabolism interactions have on GVHD have teamed up for this program project grant, which has four components.

Our overarching goal is to make allogeneic hematopoietic cell transplantation safer and more efficacious. The proposal has a unifying central theme to understand the role of intestinal microbial metabolite interactions with host metabolism and the impact on intestinal GVHD, says principal investigator Pavan Reddy, M.D., deputy director of the Rogel Cancer Center and division chief of hematology/oncology at Michigan Medicine.

The projects will address the importance of the microbiome in mitigating the severity of graft-versus-host disease and improving outcomes after allogeneic transplants.

The proposal is supported by four core services, which are led by Gregory Dick, Ph.D., Tom Braun, Ph.D., Eric Martens, Ph.D., and Costa Lyssiotis, Ph.D. The collaboration represents multiple schools across the University of Michigan, including the Medical School, the School of Public Health and the College of Literature, Science and the Arts.

This project brings together a team of investigators from diverse fields and schools, who have worked and published together previously. These collective projects are the results of unifying our preliminary datasets over the past several years. We hope that by working collaboratively we can make a difference for patients receiving hematopoietic cell transplants, Reddy says.

Grant citation: 1P01HL149633-01

Resources:

University of Michigan Rogel Cancer Center, http://www.rogelcancercenter.org

Michigan Health Lab, http://www.MichiganHealthLab.org

Michigan Medicine Cancer AnswerLine, 800-865-1125

# # #

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Latest Update 2020: What Are the Key Players Evolving In the Growth of the 3D Cell Culture Market? – re:Jerusalem

Posted: October 28, 2020 at 3:51 am

Post COVID-19 Impact on 3D Cell Culture Market With the emergence of the COVID-19 crisis, the world is fighting a health pandemic as well as an economic emergency, almost impacting trillions of dollars of revenues. Research Dive group of skilled analysts provide a solution to help the companies to survive and sustain in this economic crisis. We support companies to make informed decisions based on our findings resulting from the comprehensive study by our qualified team of experts.

Our study helps to acquire the following: Long-term and short-term impact of Covid-19 on the market Cascading impact of Covid-19 on 3D Cell Culture Market, due to the impact on its extended ecosystem Understanding the market behavior Pre- and Post-COVID-19 pandemic Strategy suggestions to overcome the negative impact or turn the positive impact into an opportunity Well help you fight this crisis through our business intelligence solutions.

Pre COVID-19 Analysis of 3D Cell Culture Market

According to a study of Research Dive, global 3D Cell Culture market forecast shall cross $12,638.8 million by 2026, growing at a CAGR of 29.4 during forecast period.

3D Cell culture is an essential tool in clinical analysis and biological science. It has multiple applications such as in biosensors, drug screening and others. Many improvements have been made in automated high-throughput cell culture systems. Increasing demand for regenerative medicine and economic drug discovery is expected to drive the demand for the 3D cell culture market. 3D cell cultures are primarily used to observe the abnormal behavior of cells and the cell-cell interaction. Furthermore, 3D cell culture systems play a significant role in the development of precision medicine and personalized medicine. For instance, as per study of cancer researchers (University of Michigan) newly invented 3D structure could enable physicians to test medications on model tumors grown from a patients own cells. These advances are projected to boost the growth of global cell culture market. However, more complex culture system, added expenses and threats from substitutes like 2D cell cultures are projected to limit the 3D cell culture market growth.

With new advances, 3D composite scaffolds have many versatile properties. It will be tremendously useful to develop treatments for nerve disorders and spinal cord injury (SCI) by taking help of cell transplantation methodologies and biomaterials. The most remarkable advantage of 3D cell culture is, their properties can be easily adapted by modifying the structure and composition. These key factors of 3D cell culture are projected to create enormous opportunities for the growth of 3D cell culture industry.

According to Analyst Evaluation, Microchips market shall register a revenue of $2,515.5 million by the end of 2026, growing at a CAGR of 30.1% during the forecast period; this is significantly due to new advances in 3D culture organs-on-chips. Organs-on-chips allow study of human physiology and also reveal development of novel in vitro disease models. It could provide potential replacements for animals used in toxin testing and drug development. These advancements are anticipated to grow the demand of microchips in global market, and are projected to boost the global market. Scaffold-based platforms have the largest market share and this segment will register a revenue of $3,425.1 million by the end of 2026, growing at a CAGR of 28.4%. Scaffolds can be significantly used in drug development therapeutic or specialty areas; which is anticipated to fuel the of global market growth.

Based on applications, the market is segmented into Stem Cell research, drug discovery, cancer research, and regenerative medicine. 3D cell culture market size for cancer research will generate a revenue of $4,057.1 million by 2026, growing at a CAGR of 28.5% throughout the forecast period; this is majorly due to various types of cancers such as breast cancer, lung cancer and others being dominant among the population. Cancer has a pervasive prevalence across the globe, which has led to rise in demand for cancer research, which is further attributed to boost the demand for 3D cell culture market. 3D cell culture market for regenerative medicine will register a revenue of $3,690.5 million by 2026, growing at a CAGR of 30.1%. Many developed and developing countries such as Japan is focusing more on contract manufacturing tie-ups, and continues to be a lucrative place for biotech ventures to do business. Japan is the world leader in regenerative medical products; these key strategies of the government are anticipated to spur the growth of 3D cell culture market.

3D cell culture market for biotechnology & pharmaceutical companies will register a revenue of $5,184.4 million by 2026, growing at a CAGR of 28.9% during the forecast period; this is majorly due to huge developments in the laboratory, technology and operations. Furthermore, rising pressure on sales of established treatments, rapid growth of cell therapies and focus on advanced manufacturing and technologies are the factors expected to grow the market.

Heavy investments in research & development, high healthcare expenditure, and extensively increasing number of cancer cases are considered to be one of the driving factors that are booming the growth of North American market.

3D Cell Culture market share for Asia-Pacific region is expected to rise at a CAGR of 30.7% by generating a revenue of $3,020.7 million by 2026. The market growth in the region is increasing drug discovery initiatives among pharmaceuticals and biotechnology companies in the region. Major economies such as India, Singapore, Japan and South Korea are emphasizing more on public sector openness to partnership with established companies. For instance, leading market players such as Bayer, GlaxoSmithKline and AstraZeneca are collaborating with Singapore partners across drug discovery.

The major 3D Cell Culture manufacturers includeQGel SA, Hrel Corporation, SynVivo, Greiner Bio-One International, Advanced BioMatrix, Lonza, Corning Incorporated, Thermo Fisher Scientific, TissUse GmbH, 3D Biotek. Players using updated technologies for their 3D Cell Culture will have good probability of having success in the rapidly blooming market. For example, Lonza has innovated the RAFT 3D Culture System that produces hepatocytes with increased stability and stronger cytochrome responses.

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Mr. Abhishek PaliwalResearch Dive30 Wall St. 8th Floor, New YorkNY 10005 (P)+ 91 (788) 802-9103 (India)+1 (917) 444-1262 (US) TollFree : +1 -888-961-4454Email:support@researchdive.comLinkedIn:https://www.linkedin.com/company/research-diveTwitter:https://twitter.com/ResearchDiveFacebook:https://www.facebook.com/Research-DiveBlog:https://www.researchdive.com/blogFollow us on:https://covid-19-market-insights.blogspot.com

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Prowess of Bionano Genomics’ Saphyr System in Uncovering Novel Genetic Variations That Cause Cancer and Genetic Disease in Full Display at ASHG 2020 -…

Posted: October 28, 2020 at 3:51 am

SAN DIEGO, Oct. 27, 2020 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) announced that human genetics researchers using the Saphyr system will present their results at the American Society of Human Genetics (ASHG) Annual Meeting, being held virtually at http://www.ashg.org between October 27-30. The impact of structural variation analysis using the Saphyr system will be demonstrated at ASHG with 18 oral and poster presentations which cover an expanding array of diseases like cancer predisposition, microdeletion syndromes, repeat expansion disorders, neurodegenerative diseases, disorders of sex development and a variety of other genetic diseases. Additionally, these presentations show Saphyrs abilities to elucidate the exact structure of complex genomic rearrangements such as large inversions, chromothripsis and low copy repeats.

The scientific importance and quality of the studies utilizing Saphyr and presented at ASHG have increased year over year, said Erik Holmlin, Ph.D., CEO of Bionano. As more scientists present and publish their important discoveries made with Saphyr, an increasing number of potential future Saphyr users become aware of its prowess in uncovering novel genetic variants that contribute to cancer and genetic disease, which could drive more adoption and utilization for basic genetic research and clinical studies alike.

Below is a summary of key presentations to be given at ASHG 2020 featuring the use of Bionanos optical genome mapping technology:

Live Presentation October 29, 2020, 11:45AM-12:00PMDeciphering Genomic InversionsChristopher M. Grochowski, Baylor College of MedicineGenomic inversions are a class of structural variation (SV) relevant in evolution, speciation, and human disease but challenging to detect and resolve using current genomic assays. While short-read WGS can detect a fraction of copy number neutral inversions, those mediated by repeats or accompanied by CNVs remain challenging. The utilization of multiple technologies and visualization of unbroken DNA through long molecule approaches facilitate detection ofin cisevents and resolution of SVs containing two or more breakpoint junctions.

The following Co-Labs, Poster Sessions and Abstracts are available for on-demand viewing during and after ASHG 2020:

Bionano Laboratory Co-Lab Session: Resolving Complex Haplotypes Implicated in Alzheimers and Other Neurodegenerative Diseases.Mark T. W. Ebbert, Neuroscience Department, Mayo ClinicAlzheimers disease is genetically complex with no meaningful therapies or pre-symptomatic disease diagnostics. Most of the genes implicated in Alzheimers disease do not have a known functional mutation, meaning there are no known molecular mechanisms to help understand disease etiology.

In this co-lab session, Mark T. W. Ebbert of the Mayo Clinic will discuss his teams work toward identifying functional structural mutations that drive disease in order to facilitate a meaningful therapy and pre-symptomatic disease diagnostic. Some of the genes and regions implicated in Alzheimers disease are genomically complex and cannot be resolved with short-read sequencing technologies. These regions include MAPT, CR1, and the histocompatibility complex (including the HLA genes).

3342 Bionano Poster Session: High Throughput Analysis of Disease Repeat Expansions and Contractions by Optical MappingErnest Lam, Sr Manager Bioinformatics, Bionano GenomicsRepeat expansions and contractions are associated with degenerative disorders such as facioscapulohumeral muscular dystrophy (FSHD). Southern Blotting is the gold standard for long repeat analysis but has many limitations. Optical genome mapping allows for efficient analysis of diseases associated with repeat expansion and contraction.

2190 Bionano Poster Session: Rapid Automated large Structural Variation Detection in Mouse Genome by Whole Genome SequencingJill Lai, Sr Applications Scientist, Bionano GenomicsIdentifying SVs for key model organisms such as mouse and rat is essential for genome interpretation and disease studies but has been historically difficult due to limitations inherent to available genome technologies. We updated the Saphyr analysis pipeline such that copy number variant (CNV) and SV analyses could now be applied to mouse and other non-human species, and constructed a control SV database for annotating variants, and identified strain-specific SVs/CNVs as well as variation shared among strains.

Additional presentations/abstracts featuring optical genome mapping:

3208 - Long-read sequencing and optical mapping decipher structural composition ofATXN10repeat in kindred with spinocerebellar ataxia and Parkinsons diseasePresented by Birgitt Schuele, Associate Professor, Department of Pathology, Stanford University School of Medicine

3270 - Uniparental isodisomy, structural and noncoding variants involved in inherited retinal degeneration (IRD) in three pedigreesPresented by Pooja Biswas, Ophthalmology Department, University of California, San Diego

Data CoLab: Whole Genome Map Assembly and Structural Variation Analysis with Hitachi Human Chromosome ExplorerPresented by Hitachi-High-Tech America, Inc.

2123 - High-throughput sequencing and mapping technologies applied to 10 human genomes with chromothripsis-like rearrangementsPresented by Uir Souto Melo, Mundlos Lab, Max Planck Institute for Molecular Genetics, Berlin, Germany

2165 -nanotatoR: A tool for enhanced annotation of genomic structural variantsPresented by Emmanuele Delot, Center for Genetic Medicine Research, Childrens National Hospital, Washington, DC

2998 - Highly variable structure and organization of the human 3q29 subtelomeric segmental duplicationsPresented by Umamaheswaran Gurusamy, Cardiovascular Research Institute, University of California San Francisco

2304 - Enlightening the dark matter of the genome: Whole genome imaging identifies a germline retrotransposon insertion inSMARCB1in two siblings with atypical teratoid rhabdoid tumorPresented by Mariangela Sabatella, Princess Mxima Center for Pediatric Oncology, Utrecht, Netherlands

2318 - FaNDOM: Fast Nested Distance-based seeding of Optical MapsPresented by Siavash Raeisi Dehkordi, Computer Science & Engineering, University of California San Diego, La Jolla

3023 - Structural hypervariability of low copy repeats on chromosome 22 is human specificPresented by Lisanne Vervoort, Department of Human Genetics, KU Leuven, Leuven, Belgium

3024 - Telomere-to-telomere assembly and complete comparative sequence analysis of the human chromosome 8 centromereReviewer's Choice Award RecipientPresented by Glennis Logsdon, Genome Sciences, University of Washington, Seattle, WA

3311 - Comprehensive structural variant identification with optical genome mapping and short-read sequencing for diagnosis of disorders/differences of sex development (DSD)Reviewer's Choice Award RecipientPresented by Hayk Barseghyan, Center for Genetic Medicine Research, Children's National Hospital, Washington, DC

3318 - De novo mutation and skewed X-inactivation in girl with BCAP31-related syndromePresented by H.J. Kao, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

3560 - Resolving genomic structures inMECP2Duplication Syndrome provides insight into genotype-phenotype correlationsReviewer's Choice Award RecipientPresented by Davut Pehlivan, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

2157 -methometR: quantification of long-range haplotype specific methylation levels from Optical Genome MapsPresented by Surajit Bhattacharya, Center for Genetic Medicine Research, Childrens Research Institute, Childrens National Hospital, Washington, DC

About Bionano GenomicsBionano is a genome analysis company providing tools and services based on its Saphyr system to scientists and clinicians conducting genetic research and patient testing, and providing diagnostic testing for those with autism spectrum disorder (ASD) and other neurodevelopmental disabilities through its Lineagen business. Bionanos Saphyr system is a platform for ultra-sensitive and ultra-specific structural variation detection that enables researchers and clinicians to accelerate the search for new diagnostics and therapeutic targets and to streamline the study of changes in chromosomes, which is known as cytogenetics. The Saphyr system is comprised of an instrument, chip consumables, reagents and a suite of data analysis tools, and genome analysis services to provide access to data generated by the Saphyr system for researchers who prefer not to adopt the Saphyr system in their labs. Lineagen has been providing genetic testing services to families and their healthcare providers for over nine years and has performed over 65,000 tests for those with neurodevelopmental concerns. For more information, visitwww.bionanogenomics.com or http://www.lineagen.com.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the timing and content of the presentations identified in this press release; the effectiveness and utility of Bionanos technology in basic genetic research and clinical settings; the contribution of Saphyr to uncovering novel genetic variants that contribute to cancer and genetic disease; the benefits of Bionanos optical mapping technology and its ability to facilitate genomic analysis in future studies; and Bionanos strategic plans. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive products; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; the loss of key members of management and our commercial team; and the risks and uncertainties associated withour business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission, including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2019 and in other filings subsequently made by us with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management's assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

CONTACTSCompany Contact:Erik Holmlin, CEOBionano Genomics, Inc.+1 (858) 888-7610eholmlin@bionanogenomics.com

Investor Relations Contact:Ashley R. RobinsonLifeSci Advisors, LLC+1 (617) 430-7577arr@lifesciadvisors.com

Media Contact:Darren Opland, PhDLifeSci Communications+1 (617) 733-7668darren@lifescicomms.com

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Prowess of Bionano Genomics' Saphyr System in Uncovering Novel Genetic Variations That Cause Cancer and Genetic Disease in Full Display at ASHG 2020 -...

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