Page 875«..1020..874875876877..880890..»

University of Wisconsin Researchers Use Stem Cells to Treat Parkinson’s – Gilmore Health News

Posted: October 8, 2020 at 9:55 am

Parkinsons is a progressive neurodegenerative disorder that characteristically affects the dopamine-producing neurons in the substantia nigra or the midbrain. It usually begins with stiffness, shaking, tremors, voice changes, and postural instability, all of which worsen with time, resulting in difficulty walking and talking.

Man With Parkinsons

Parkinsons is a widely common neurodegenerative disease affecting approximately 10 million people worldwide, as of 2019. And the rate of incidence increases with age, for example, it affects 1 percent of individuals over the age of 60 years in comparison to 5 percent of individuals over the age of 85 years.

Read Also: Parkinsons Disease: A Promising Treatment Thanks to Stem Cells

Parkinsons is a nervous system disorder that predominantly affects the motor function of the patient, therefore reducing the quality of life significantly. Unfortunately, Parkinson does not have a cure but there are many supportive therapeutic options available for the patients in the form of physical therapy, and medication along with a treatment option including deep brain stimulation (DBS).

DBS has shown great results but it is an invasive procedure that only produces temporary results. Hence, more research and studies need to be performed in the field of nervous system disorders to discover better therapeutic approaches.

Parkinsons and other nervous system disorders like stroke, Huntingtons, and so on are difficult to cure or treat due to the extensive damage to the neurons seen in these diseases. This is a problem because neurons are infamous for their inability to regenerate. Although stem cells that can be adapted into neurons may be recommended as a therapeutic option, they come with a problem of their own.

The new neurons do not connect with the native neurons as they do not recognize or identify them. This results in no improvement in neuronal circuitry and in the patients condition.

A recent study published in Cell Stem Cell Journal by Su-Chun Zhang, Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, and her team claim to have derived neurons from human stem cells that can be used to repair circuitry and improve neural functions.

Read Also: Antibiotics May Increase Your Risk of Having Parkinsons Disease

Zhang and her team derived dopamine-producing neurons from human embryonic stem cells and then transplanted these into the substantia nigra of the brain in animal models with Parkinsons disease.

These transplanted cells also contained on and off switches that could be stimulated externally using certain drugs or foods.

Zhang and her team found that these transplanted cells formed connections with native neurons and grew long-distance to form connections with the motor control regions in the brain to improve the motor functions usually affected by Parkinsons. The results were visible after a few months of transplantation, the time needed for the transplanted neurons to integrate into the brain.

To confirm that the improvement seen in the mice was due to the transplanted cells, the on and off switches were stimulated by the research team.

Read Also: Implants from Own Stem Cells May Offer Solution to Back Pain, Researchers Say

When the cells were turned off, the symptoms of Parkinsons reappeared indicating the proper functioning of these cells in the treatment of the neurodegenerative disorder. Furthermore, the scientists on closer look found that these cells were identified by native neurons and had been integrated into the midbrain. Moreover, the researchers believe that these switches can be used to fine-tune the treatment option for the patients.

The research team is currently applying these results to the primates model and aims to use the results from Parkison disease models for other nervous system disorders as well.

Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function

Medical University of Vienna: Vitamin B1 May Help Prevent Alcohol-Related Dementia

Old Human Cells Successfully Rejuvenated Via Stem Cell Technology

Is NAD+ The Anti Aging Substance Mankind Has Been Searching For?

Anti-Aging: A New Way to Repair Age Related DNA Damage Discovered

Anti-Aging: HGH Can Reduce Biological Age by One Year and a Half Study Shows

Genf20 Plus Review: Why Are People Rushing to Buy This HGH Supplement?

University of Utah: Could Slowing the Rate of DNA Mutations Be the Key to the Elusive Fountain of Youth

Excerpt from:
University of Wisconsin Researchers Use Stem Cells to Treat Parkinson's - Gilmore Health News

Posted in Stem Cell Research | Comments Off on University of Wisconsin Researchers Use Stem Cells to Treat Parkinson’s – Gilmore Health News

Forsyth researchers demonstrate how changing the stem cell response to inflammation may reverse periodontal disease – Science Codex

Posted: October 8, 2020 at 9:55 am

Periodontal disease, also known as gum disease, is a serious infection that affects nearly 50 percent of Americans aged 30 years and older. If left unchecked, periodontal disease can destroy the jawbone and lead to tooth loss. The disease is also associated with higher risk of diabetes and cardiovascular disease.

The current treatment for periodontal disease involves opening the infected gum flaps and adding bone grafts to strengthen the teeth. But in new research published recently in the journal Frontiers in Immunology, Forsyth Institute scientists have discovered that a specific type of molecule may stimulate stem cells to regenerate, reversing the inflammation caused by periodontal disease. This finding could lead to the development of new therapeutics to treat a variety of systemic diseases that are characterized by inflammation in the body.

For the study, Dr. Alpdogan Kantarci, his PhD student Dr. Emmanuel Albuquerque, and their team removed stem cells from previously extracted wisdom teeth and placed the stem cells onto petri dishes. The researchers then created a simulated inflammatory periodontal disease environment in the petri dishes. Next, they added two specific types of synthetic molecules called Maresin-1 and Resolvin-E1, both specialized pro-resolving lipid mediators from omega-3 fatty acids. The scientists found that Mar1 and RvE1 stimulated the stem cells to regenerate even under the inflammatory conditions.

"Both Maresin-1 and Resolvin-1 reprogrammed the cellular phenotype of the human stem cells, showing that even in response to inflammation, it is possible to boost capacity of the stem cells so they can become regenerative," said Dr. Kantarci, Associate Member of Staff at the Forsyth Institute.

This finding is important because it allows scientists to identify the specific protein pathways involved in inflammation. Those same protein pathways are consistent across many systemic diseases, including periodontal disease, diabetes, heart disease, dementia, and obesity.

"Now that we understand how these molecules stimulate the differentiation of stem cells in different tissues and reverse inflammation at a critical point in time, the mechanism we identified could one day be used for building complex organs" said Dr. Kantarci. "There is exciting potential for reprogramming stem cells to focus on building tissues."

Originally posted here:
Forsyth researchers demonstrate how changing the stem cell response to inflammation may reverse periodontal disease - Science Codex

Posted in Stem Cell Research | Comments Off on Forsyth researchers demonstrate how changing the stem cell response to inflammation may reverse periodontal disease – Science Codex

Stem Cell Manufacturing Market Business Growth, Size and Comprehensive Research Study Forecast to 2026| Thermo Fisher, Merck Group, Becton Dickinson -…

Posted: October 8, 2020 at 9:55 am

Stem Cell Manufacturing Market Report Delivering Growth Analysis with Key Trends of Top Companies (2020-2026)

A comprehensive research study on the Stem Cell Manufacturing Marketwas recently published by Market Report Expert. This is an up-to-date report, covering the current COVID-19 impact on the market. The Coronavirus (COVID-19) has affected every aspect of life globally and thus altering the global market scenario. The changes in the market conditions are drastic. The swiftly changing market scenario and initial and future assessment of the impact on Stem Cell Manufacturing market is covered in the report.The Stem Cell Manufacturing Market report is a precise and deep-dive study on the current state that aims at the major drivers, market strategies, and imposing growth of the key players. Worldwide Stem Cell Manufacturing Industry also offers a granular study of the dynamics, segmentation, revenue, share forecasts, and allows you to make superior business decisions. The report serves imperative statistics on the market stature of the prominent manufacturers and is an important source of guidance and advice for companies and individuals involved in the Stem Cell Manufacturing industry.

The Global Stem Cell Manufacturing Market poised to grow from US$ XX million in 2020 to US$ XX million by 2026 at a compound annual growth rate (CAGR) of XX% during the projection period of 2020-2026.

An Outline of the Major Key Players covered in this Report:

Thermo Fisher, Merck Group, Becton Dickinson, Bio-Rad, Miltenyi Biotec, Takara Bio, STEMCELL, Pharmicell, Osiris, Anterogen, Cellular Dynamics, MEDIPOST, Lonza, Holostem, Pluristem

Get Free LatestPDF Template of this Report(Including Covid-19 impact analysis on overall industry Forecast, Size, Share, CAGR and more.)@ https://www.marketreportexpert.com/report/Stem_Cell_Manufacturing/14213/sample

Note: We can also provide market report in German/French Language.

The report puts together a succinct analysis of the growth drivers influencing the current business scenario across various regions and countries. Substantial information pertaining to the industry analysis size, share, application, and statistics are summed in the report in order to present a collaborative prediction. Additionally, this report encompasses a precise competitive analysis of major market players, innovative companies, and their strategies during the projection timeline.

The latest report on the Stem Cell Manufacturing Market consists of an analysis of this industry and its type, application, and other segments. As per the report, the market is estimated to gain significant returns and register substantial y-o-y growth during the forecast period of 2020-2026.

Majortype, primarily split into

HSCsMSCsiPSCsESCsInstrumentsMediaConsumables

Major applications/end users, including

ResearchTarget IdentificationTherapyCell Banks

According to the report, the study offers details regarding the valuable estimations of the market such as market size, sales capacity, and profit projections. The report documents factors such as drivers, restraints, and opportunities that impacts the remuneration of this market.

Feel Free! Ask Our Industry Expert For Discount on this Report(Note: Our reports include the analysis of the impact of COVID-19 on this industry. Our updated sample pages shows impact of Covid-19 on Industry trends. Also we are offering 20% discount.): https://www.marketreportexpert.com/report/Stem_Cell_Manufacturing/14213/inquiry

The research offers an analysis of the geographical landscape of the Stem Cell Manufacturing Market, which is divided into regions such as North America, Europe, Asia Pacific, South America, and the Middle East & Africa. The segment includes data about several parameters related to the regional contribution such as market share, application share, type share, key companies in respective regions, market share of key companies in regional market, growth rate and revenue of the regional market, sales, production, and consumption of the respective Stem Cell Manufacturing market.

Major Highlights of TOC Covers:

Stem Cell Manufacturing Market 2020, Stem Cell Manufacturing Market size, Stem Cell Manufacturing Market share, Stem Cell Manufacturing Market analysis, Stem Cell Manufacturing Market forecast, Stem Cell Manufacturing Market trends, Stem Cell Manufacturing Market Research report, Stem Cell Manufacturing application, Stem Cell Manufacturing Trends, Stem Cell Manufacturing Market growing CAGR, Stem Cell Manufacturing Market Competitive Landscape, Stem Cell Manufacturing Market Growth

Information related to the growth rate, revenue, sales, production, consumption, during the forecast period is included in the report. The Stem Cell Manufacturing Market report claims that the industry is projected to generate significant revenue and sales during the forecast period. The report consists of information related to the market dynamics such as challenges involved in this vertical, growth opportunities, and driving factors affecting the market.

About Us

Market Report Expert is a futuristic market intelligence company, helping customers flourish their business strategies and make better decisions using actionable intelligence. With transparent information pool, we meet clients objectives, commitments on high standard and targeting possible prospects for SWOT analysis and market research reports.

Contact USJames ThompsonMarket Report ExpertPhone: +1-816-301-6258Email inquiry@marketreportexpert.comWeb:-https://www.marketreportexpert.com

Read this article:
Stem Cell Manufacturing Market Business Growth, Size and Comprehensive Research Study Forecast to 2026| Thermo Fisher, Merck Group, Becton Dickinson -...

Posted in Stem Cell Research | Comments Off on Stem Cell Manufacturing Market Business Growth, Size and Comprehensive Research Study Forecast to 2026| Thermo Fisher, Merck Group, Becton Dickinson -…

Cytovia Therapeutics partners with Inserm to develop selective CD38 NK therapeutics and offer new treatment options for Multiple Myeloma patients |…

Posted: October 8, 2020 at 9:55 am

DetailsCategory: DNA RNA and CellsPublished on Thursday, 08 October 2020 15:15Hits: 58

NEW YORK, NY, USA and PARIS, France I October 08, 2020 I Cytovia Therapeutics ("Cytovia"), an emerging biopharmaceutical company, announces today that it has entered a research and licensing agreement with Inserm to develop NK engager bi-specific antibodies and iPSC CAR NK cell therapy targeting CD38, a key marker of multiple myeloma. The licensing agreement has been negotiated and signed by Inserm Transfert, the private subsidiary of Inserm, on behalf of Inserm (the French National Institute of Health and Medical Research) and its academic partners. Cytovia is licensing Inserm's CD38 antibody and Chimeric Antigen Receptor (CAR) patent and applying its proprietary NK engager bispecific antibody and iPSC CAR NK technology platforms. The research agreement will include evaluation of the therapeutic candidates at Hpital Saint-Louis Research Institute (Inserm Unit 976) under the leadership of Professors Armand Bensussan and Jean-Christophe Bories.

Dr Daniel Teper, Cytovia's Chairman and CEO commented: "We are delighted to partner with one of the top centers of excellence in the world for research and treatment in hematology. CD38 is a validated target and Natural Killer cells have significant cytotoxicity to Myeloma cells. We are looking forward to bringing promising new options to address the unmet needs of patients with Multiple Myeloma and aim for a cure."

Professor Armand Bensussan, Director of The Immuno-Oncology Research Institute at Hpital Saint-Louis added: "We have demonstrated the selectivity of our novel CD38 antibody in killing myeloma cells but not normal cells such as NK, T, and B cells. The activation of NK cells through NKp46 may enhance the efficacy of the bispecific antibody in patients not responsive to CD38 monoclonal antibody therapy. CD38 CAR NK is a promising approach forrelapsed/refractory patients and an alternative to CAR T therapies."

About Multiple MyelomaMultiple Myeloma is a currently incurable cancer, affecting a type of white blood cell known as plasma cells. It leads to an accumulation of tumor cells in the bone marrow, rapidly outnumbering healthy blood cells. Instead of producing beneficial antibodies, cancerous cells release abnormal proteins causing several complications. While symptoms are not always present, the majority of patients are diagnosed due to symptoms such as bone pain or fracture, low red blood cell counts, fatigue, high calcium levels, kidney problems, and infections. According to the World Cancer Research Fund, Multiple Myeloma is the second most common blood cancer, with nearly 160,000 new annual cases worldwide, including close to 50,000 in Europe. 32,000 in the US, and 30,000 in Eastern Asia. Over 95% of cases are diagnosed late, with a 5-year survival rate of 51%. Initial treatment comprises of a combination of different therapies, including biological and targeted therapies, corticosteroids, and chemotherapy, with the option for bone marrow transplants for eligible patients. Immunotherapy and cell therapy are the most promising new treatment option for Multiple Myeloma, with the potential for long term cancer remission.

About CAR NK cellsChimeric Antigen Receptors (CAR) are fusion proteins that combine an extracellular antigen recognition domain with an intracellular co-stimulatory signaling domain. Natural Killer (NK) cells are modified genetically to allow insertion of a CAR. CAR-NK cell therapy has demonstrated initial clinical relevance without the limitations of CAR-T, such as Cytokine Release Syndrome, neurotoxicity or Graft vs Host Disease (GVHD). Induced Pluripotent Stem Cells (iPSC) - derived CAR-NKs are naturally allogeneic, available off-the-shelf and may be able to be administered on an outpatient basis. Recent innovative developments with the iPSC, an innovative technology, allow large quantities of homogeneous genetically modified CAR NK cells to be produced from a master cell bank, and thus hold promise to expand access to cell therapy for many patients.

About CytoviaCytovia Therapeutics Inc is an emerging biotechnology company that aims to accelerate patient access to transformational immunotherapies, addressing several of the most challenging unmet medical needs in cancer and severe acute infectious diseases. Cytovia focuses on Natural Killer (NK) cell biology and is leveraging multiple advanced patented technologies, including an induced pluripotent stem cell (iPSC) platform for CAR (Chimeric Antigen Receptors) NK cell therapy, next-generation precision gene-editing to enhance targeting of NK cells, and NK engager multi-functional antibodies. Our initial product portfolio focuses on both hematological malignancies such as multiple myeloma and solid tumors including hepatocellular carcinoma and glioblastoma. The company partners with the University of California San Francisco (UCSF), the New York Stem Cell Foundation (NYSCF), the Hebrew University of Jerusalem, and CytoImmune Therapeutics. Learn more at http://www.cytoviatx.com

About InsermFounded in 1964, the French National Institute of Health and Medical Research (Inserm) is a public science and technology institute, jointly supervised by the French Ministry of National Education, Higher Education and Research, and the Ministry of Social Affairs, Health and Womens Rights. Inserm is the only French public research institute to focus entirely on human health and position itself on the pathway from the research laboratory to the patients bedside. The mission of its scientists is to study all diseases, from the most common to the rarest. With an initial 2020 budget of 927.28 million, Inserm supports nearly 350 laboratories throughout France, with a team of nearly 14,000 researchers, engineers, technicians, and post-doctoral students. http://www.inserm.fr

SOURCE: Cytovia Therapeutics

Read the original:
Cytovia Therapeutics partners with Inserm to develop selective CD38 NK therapeutics and offer new treatment options for Multiple Myeloma patients |...

Posted in Stem Cell Research | Comments Off on Cytovia Therapeutics partners with Inserm to develop selective CD38 NK therapeutics and offer new treatment options for Multiple Myeloma patients |…

What Nutritionists Need You to Know About Smoke Point and Cooking Oils – msnNOW

Posted: October 8, 2020 at 9:54 am

5 Cooking Hacks to Eat Less Sodium

Click to expand

UP NEXT

At some time in the kitchen, you've likely seen cooking oil smoke and burn. Watching that smoke billow is an unpleasant sight and smell, forcing you to turn on the exhaust fan and rush to open the windows. But how does it affect the oil's taste and quality? Is smoking oil really such a bad thing? (Beware of these cooking mistakes that can make food toxic.)

We spoke with top chefs and registered dietitian nutritionists about what the smoke point of oils means, how overheating oil can alter nutrients, and the potentially harmful impacts of burning and smoking oil.

The smoke point of an oil refers to the temperature at which it begins to smokeand also degrade in both quality and taste. Typically, the odor of an oil becomes at least somewhat foul once it begins smoking.

"Food can taste burnt if the oil it has been cooked in has started to smoke," says Lisa Andrews, RD, a registered dietitian in Cincinnati.

An oil's smoke point affects what you're able to accomplish with it. For instance, peanut oil has a smoke point of 450 F, which makes it suitable for deep-frying, according to the U.S. Department of Agriculture (USDA). Extra-virgin olive oil, on the other hand, has a smoke point of 405 F; that lower number makes this oil better suited for roasting and baking, says the Institute of Food Technologists.

Smoke points most often become an issue with higher-temperature cooking, such as sauting, pan searing, stir frying, and pan frying, says Michele Redmond, a chef and dietitian in Scottsdale, Arizona. "It's important to know the smoke point of an oil because it alters the taste of foodand not in a good way," she adds. "Knowing some basic smoke point ranges can make you a more efficient, flavor-sensitive cook." (Get the scoop on the healthiest cooking oils.)

Curious about what happens to an oil once it begins to smoke? A lot. "Oil smokes when direct heat applied to it reacts with oxygen enough to burn and create smoke," says Redmond.

Know, however, that a smoke point of an oil isn't an exact science. Consider, instead, a smoke point as a range of temperatures. "A single type of oil can have multiple smoke points, depending on the seed variety, processing, fatty acid profile, exposure to air and light, and the amount of trace carbohydrates, minerals, proteins, and aromatic compounds," says Redmond.

Unfortunately, there's no easy way to tell from an oils fat content whether it has a higher smoke point. A high smoke point oil can be loaded with good-for-you mono- and polyunsaturated fats, or it can depend on saturated fats. Palm oil, with nearly 7 grams saturated fat, 5 grams monounsaturated fat, and 1 gram polyunsaturated fat per tablespoon, has a high smoke point of 450 F, per the USDA database. The same amount of refined avocado oil, on the other hand, which has a smoke point of up to 500 F, contains just under 2 grams saturated fat, 10 grams monounsaturated fat, and 2 grams polyunsaturated fat. The lower levels of saturated fat and high amounts of monounsaturated fat makes avocado a much more nutritious pick if you need something to fry with.

Then there are also high-oleic oils to consider (oleic refers to omega-9 fatty acids, a type of monounsaturated fat). One popular example is sunflower oil. "Cooking oils high in oleic acids are less sensitive to heat because they are made using plants bred to have more monounsaturated fats and fewer omega-6 polyunsaturated fats," says Redmond. "For example, traditional sunflower oil is about 20 percent oleic acid, versus 80 percent in high-oleic acid sunflower oil. This makes it more stable for cooking at high heats and gives it a longer shelf life."

Now, what can happen when oil gets too hot? Let's investigate.

Foods readily absorb oil, so anything sitting in smoking oil can absorb acrid and burnt flavors. "The No. 1 reason we choose certain foods is because of taste," says Lexi Endicott, RD, a registered dietitian in Boise, Idaho. "And foods cooked in burnt oil may taste bitter, burnt, or rancid."

Gallery: The 10 Healthiest Cooking Oils, According to Food Experts (The Healthy)

"Olive and sesame oils have low smoke points," adds Andrews. "When used in high heat, they will break down and impart an off taste to your food. Avocado and sunflower oil, on the other hand, can tolerate higher temperatures and would be better suited for deep frying or roasting vegetables on high heat."

"If you leave an oil smoking in your pan for too long, you risk it hitting its flash point of catching on fire," says Redmond. Plus, the clean-up is not fun. As oil thickens, which happens when it catches on fire, says Redmond, it gets sticky and harder to scrub away.

Just as overly grilled BBQ food poses a carcinogenic risk, the same goes for overly heated oil.

"As an oil passes its smoke point, the part of the oil's triglyceride structure is broken apart from the fatty acidsand free fatty acids, aldehydes, and polar compounds are released," says Endicott. "As the glycerol continues to heat, it is further broken down to acrolein, an irritating compound to the eyes and throat. Increased acrolein exposure may increase cancer risk, as it disrupts normal RNA [ribonucleic acid] and DNA [deoxyribonucleic acid] function." That increases the likelihood of cell mutations that can lead to tumor growth.

Another reason why cooking food in smoking oil is a no go? "The higher the temperature that an oil is cooked at, the increased likelihood of free radical production," says Endicott. "Free radicals are known to alter cellular function, which may lead to increased cancer risk."

Bottom line: It's better to not overheat cooking oils. "Healthy fat is incredibly healthy for the health of our cells and cell membranes," says Isabel Smith, MS, RD, a registered dietitian in New York City. "We want the fat we're consuming to be high quality and not burnt!"

That doesn't mean your cancer risk increases the second your pan starts smoking. "A smoking oil doesn't mean it immediately oxidizes or becomes less stable," notes Redmond. "The amount of time an oil smokesand other variables, including the type of fatty acidscan slow these processes. For example, oils high in monounsaturated fats and antioxidants can maintain stability well."

Those same factors that may impact your cancer risk may also affect your risk of heart disease. "Consumption of polar compounds, aldehydes, and oxidized fats may also increase heart disease risk," says Endicott. "Oxidized fats cause damage to the endothelial lining of blood vessel, which over time can decrease vascular function and therefore damage proper blood flow." (Find out the food rules of an anti-inflammatory diet.)

Here's a rough guide to smoke points from the cooking tools company, Anova:

To avoid problems when an oil reaches its smoke point, here's what you can do to decrease your risk.

"Choose oils that best fit the needs of your cooking application," advises Endicott. You already know that oils with higher smoke pointsavocado and peanut oilare better suited for roasting and sauteing. Unrefined coconut oil is best used for baking and stovetop cooking.

And some oils simply aren't meant to be heated at all. "Flavor-infused oils or expensive artisan oils are better reserved for finishing," says Endicott. These include unrefined walnut, pecan, or pumpkin oils. You can use them to drizzle flavor on top of just-out-of-the-oven butternut squash, or they can also be swirled onto freshly made dip.

You might need to experiment, too. "Sometimes, you won't know the smoke point of an oil until you try cooking with it," says Endicott. "If you notice an off smell or flavor, or feel a burning sensation in your eyes, your oil has likely exceeded its smoke point." An oil will often turn clear just before it begins to smoke.

Match your cooking oil to your technique to limit smoke at high heats. Oils with smoke points at or above 350 F pair well with the high temperatures needed for direct-heat techniques like sauting, pan searing, stir frying, and pan frying.

Like life, almost nothing in the kitchen is clear cut. "In some cases, you may desire an oil that begins to smoke just before cooking," says Redmond. "Cook's Illustrated tested how a fast pan sear of meat develops better flavors and texturesand cooks faster when added to a just-smoking pan. It's a bit contrarian, but this is how chefs cook."

It may seem like your supermarket shelves are filled with more cooking oil options than you've ever seen before. Vegetable, canola, and extra virgin olive oils (EVOO) are like culinary dinosaurs next to the seemingly modern avocado or flaxseed oil. With so many choices, and so many trends in the health food community, it's hard to know which is the healthiest cooking oil to put in your cart.

"There are 'health halos' associated with some cooking oils and opposite perceptions about others, not all of which are warranted," says Kris Sollid, RD, senior director of nutrition communications of the International Food Information Council (IFIC). A health halo is the impression that a specific food is really good for you despite a lack of factual information to back up the idea.

"Where these beliefs stem from is anyone's guess, but I wouldn't rule out connotations of an oil's food source, which may, in part, be influenced by the more exotic regions of the world that some of these foods are native to," Sollid adds.

With this in mind, which healthiest cooking oil should you reach for when prepping a meal? Our food experts weigh in with multiple options for every palette. (Beware of the cooking mistakes that could make your food toxic.)

When you'd like your oil to add a little flavor to your food, olive oil is one of the most recommended options. But it's important to keep in mind that its smoke point is lower than that of canola oil, so consider how you'll be using it first and at what temperature.

"Olive oil varieties have a lower smoke point but provide bigger flavor, so they are best suited for direct consumption in things like oil and vinegar salad dressings and in lower temperature cooking techniques like sauting, pan frying, and baking," says Sollid.

He also notes that olive oil is known for its high MUFA content, but also provides a small amount of ALA, the plant form of an especially beneficial type of polyunsaturated (PUFA) omega-3 fat. (Learn more about the different types of healthy fats.)

One thing to remember, just because an oil is deemed "healthy" doesn't make it a health food. "Cooking oils are calorie denseone tablespoon contains about 120 calories and one cup contains about 1,900 calories," says Sollid. "Therefore, advice focuses on using them, even the healthiest varieties, in moderate quantities. A little goes a long way."

The post What Nutritionists Need You to Know About Smoke Point and Cooking Oils appeared first on The Healthy.

Follow this link:
What Nutritionists Need You to Know About Smoke Point and Cooking Oils - msnNOW

Posted in Idaho Stem Cells | Comments Off on What Nutritionists Need You to Know About Smoke Point and Cooking Oils – msnNOW

ABC News Debuts New Primetime Series THE CON Narrated by Whoopi Goldberg – Broadway World

Posted: October 8, 2020 at 9:52 am

Premiering October 14.

ABC News will debut the new primetime series "The Con," narrated by Emmy(R), GRAMMY(R), Tony(R) and Oscar(R) winner and "The View" moderator Whoopi Goldberg, on Wednesday, Oct. 14. The series explores the troubling tales of people taken in by claims and promises that proved too good to be true, from identity fraud and misleading romance to the high-profile college admission scandal and Fyre Festival. It will reveal how the victims were fooled and the cost of their false trust - emotional and financial. "The Con" will feature interviews with the key people caught up in the cons, including victims and eyewitnesses, and, in some cases, law enforcement and the perpetrators themselves. The series will lift the curtain on the people behind some of the most outrageous cons ever. "The Con" kicks off Wednesday, Oct. 14 (10:02-11:00 p.m. EDT), on ABC.

In the series premiere, Goldberg introduces viewers to Benita Alexander, an award-winning documentary television producer and single mother, and Paolo Macchiarini, an internationally renowned surgeon. Alexander meets Macchiarini while producing a documentary on his groundbreaking surgical techniques using stem cells in synthetic trachea transplants. Despite crossing professional lines, Alexander finds herself wooed by Macchiarini's charm, intellect and good looks, and the pair quickly falls in love. After traveling the world together, the couple gets engaged and, according to Alexander, Macchiarini tells her he wants to take over planning the wedding. It quickly becomes a grand, fairy-tale affair with an impressive guest list, including Bill Clinton, Barack Obama and Elton John. He says they'll even be married by the pope. However, weeks before their Italian wedding, Alexander realizes things aren't as perfect as they seem and uses her investigative producer skills to uncover the truth behind Macchiarini and the planned wedding.

At around the same time, the Karolinska Institute, where Macchiarini performed some of his transplant surgeries, has been digging into allegations from Macchiarini's colleagues that he fabricated parts of his medical research. Macchiarini eventually loses his position at the institute. His groundbreaking surgeries have been under investigation by Swedish prosecutors, and just last week he was indicted on charges of aggravated assault relating to three of his surgeries. A court date has yet to be set and Macchiarini has not yet entered a plea. He has denied all of the allegations against him. The premiere episode includes interviews with Alexander, her friends, family and former co-workers.

Each week, "The Con" will document a different con and its victims. Future episodes feature the stories of Johnathan Walton and con artist Marianne Smyth, who claimed to be an Irish heiress whose family was trying to swindle her out of her massive inheritance; Anthony Gignac of Michigan, who created a false identity to deceive people into thinking he was a member of the Saudi royal family; and the story of three women who paid hundreds of thousands of dollars to psychic frauds who preyed on their vulnerability and dependency.

For the series, David Sloan is senior executive producer, and Carrie Cook and Colleen Halpin serve as executive producers for ABC News. Eli Holzman and Aaron Saidman are executive producers for IPC, along with executive producer and director Star Price. The premiere episode of "The Con" is produced by ABC News. Other episodes in the series are produced by Industrial Media's The Intellectual Property Corporation (IPC) for ABC News.

More:
ABC News Debuts New Primetime Series THE CON Narrated by Whoopi Goldberg - Broadway World

Posted in Michigan Stem Cells | Comments Off on ABC News Debuts New Primetime Series THE CON Narrated by Whoopi Goldberg – Broadway World

HOME GROWN: Pumpkins best left on the vine for as long as possible – The Oakland Press

Posted: October 8, 2020 at 9:52 am

Q: When can I pick my pumpkins and how do I do it right? I have a bunch of nice ones in my garden but I dont want them to rot before Halloween.

A: The longer they can remain attached to their vines the better, even if the vines are dead. But do not allow them to get frosted or frozen.

You might want to put a small piece of board or something else under each pumpkin where it is sitting. This will keep the bottoms dry and help to prevent rotting. You also dont want those attractive slugs feeding on the softened spots.

When you do harvest the pumpkins, dont try to break the pumpkins from the stems; cut them with a knife or pruners. Cut the stem several inches above the pumpkin. This is your handle. If the stem is broken off right at the pumpkin, it can begin rotting there sooner.

Once a pumpkin is removed, be careful that it does not get bruised or have the skin broken or abraded.

If the pumpkin is damp or wet, dry it off. Some people will wipe the pumpkin with a 10% bleach solution to remove bacteria. Thats one part household bleach to nine parts water. Then, dry the pumpkin. You can tip the pumpkin on its side to let the bottom dry. Store the pumpkins out of the sun but in a cool area, such as a garage or barn. Put them on newspaper or something dry. Cold concrete floors attract moisture.

If you plan to carve the pumpkins, do it right before the holiday, because carving will cause them to break down rapidly, especially if the weather is warm. Keep them from frosting, which also breaks down the cells. Small pumpkins that are not carved can be used for pumpkin pie, and the others can be composted.

Q: I just went to the sale of all sales for plants. The deals were amazing. I bought many potted perennials for a flower garden that I have yet to make. I know I wont get this area ready until next spring. But how to I keep the plants in good shape until next spring? I have gotten some advice but I dont trust how good it is. What can I do?

A: Lets start with several things that wont work.

Leaving the plants and pots sitting on top of the ground will cause big trouble. Plants go dormant when its cold enough, but the small amount of soil in the pots will freeze and thaw dozens of times over the winter. This slow-motion yo-yo behavior will kill them.

In Michigan, the goal is for plants to go dormant as the soil freezes and stay that way until spring. The soilless potting medium in the pots is porous and freezes and thaws much more rapidly than the mineral soil in the garden. Thats why its a good idea to pick away some of the soilless stuff when you plant and integrate some of your mineral soil around the plants next spring. Do it carefully and dont trash the roots on your new plant kiddies.

The soilless medium also accepts water differently. If you have heavy soil, the water remains with the porous rootball and the roots marinate in in the small swamp you created. Root rot will soon follow.

Putting plants in a dark garage is not much protection if the winter is cold, and a heated garage does not allow them to go dormant. Packing straw or leaves around the pots is one possibility, but they still can freeze and thaw just more slowly.

The best solution is to sink your pots into the ground up to their rims. Put at least 3 inches of straw or leaves over them. You can tell where they are in the spring by the protruding rims.

If you live in Critterville, you may want to put a piece of hardware screening over the tops of the straw and weigh down the corners and sides. Hardware screening has smaller holes than chicken wire and will keep dinkies like voles out.

Questions? MSU Master Gardener Hotline 888-6783464. Gretchen Voyle is an MSU extension horticulture educator, retired.

Here is the original post:
HOME GROWN: Pumpkins best left on the vine for as long as possible - The Oakland Press

Posted in Michigan Stem Cells | Comments Off on HOME GROWN: Pumpkins best left on the vine for as long as possible – The Oakland Press

Trump was one of the first 10 patients to get an experimental COVID-19 treatment under special use – Yahoo News

Posted: October 8, 2020 at 9:51 am

Donald Trump

A car with US President Trump drives past supporters in a motorcade outside of Walter Reed Medical Center in Bethesda, Maryland on October 4, 2020. - US President Donald Trump drove past supporters outside the hospital where he was being treated for Covid-19, after announcing on Twitter a "suprise visit" to his backers. ALEX EDELMAN/AFP via Getty Images

Ahead of President Donald Trump's Monday discharge from the care of Walter Reed Medical Center, where hehad been treated forthree days for symptoms of COVID-19, came atweet.

"Don't be afraid of Covid," the presidentclaimed, inpart because the country had developed "some really great drugs."

However, the president himself who once suggested injecting household disinfectants to treat the deadly disease had just become one of thefirst 10 patients granted anextraordinarily rare level of access toan experimental antibody infusion to combathis COVID-19 infection, Salon hasconfirmed.

The treatment, a cocktail of human antibodies and anti-bodies cloned from stem cells, was manufactured by Regeneron. The pharmaceutical company onlyannouncedthe results of a phase 1/2/3 trial onSept. 29, or two days before the president tested positive. The treatment, which is still pending approval from the Food and Drug Administration,proved most effective for patients with weak immune systems.

Homicidal negligence: Trump admits on tape that he hid "deadly" threat of coronavirus from public

Watchdog questions why Wells Fargo reported giving only one large PPP loan to a Black-owned business

Hours afterreceiving the treatment on Friday, Trump was flown from the White House to Walter Reed Medical Center. The White House saidat the time that the president had"mild symptoms." Trump's personal physician, Dr. Sean Conley, later acknowledged that he exhibited low oxygen levels and a fever.

Story continues

But Conley would not disclose the results of Trump's lung scans, only saying they showed "expected findings." Experts noted that Conley did not say the president's lungs appeared healthy,leaving open the possibility ofinflammation or pneumonia.

Trump returned to the executive mansion three days later. After a balcony photo-op appearance, during which time his breathing appeared labored, the president remains at 1600 Pennsylvania Ave. Conley says Trump reports no symptoms medically different from "showing signs," which are noticed and reported by an attending physician.

After his experience at Walter Reed, Trump declared that Americans should not let the coronavirus, which has killed more than 210,000 people in the U.S. over the last seven months, "dominate your life."

Outside of clinical trials, almost no American has access to the treatments which were available to the president.The Food and Drug Administration limits compassionate use ("expanded access")to patients with "animmediately life-threatening condition or serious disease or condition" when "no comparable or satisfactory" alternativesare available.

Patients often wait for approval, which can includean involved review and regulatory processbetween the patient, the physician, the pharmaceutical company and the government. Typically, companies grant compassionate use free of charge, but other monoclonal antibodies currently on the market cost thousands of dollars.

"All we can say is that they asked to be able to use it, and we were happy to oblige," RegeneronCEO Dr. Leonard Schleifer toldThe New York Times. Though Trump was not the first patientgranted expanded access to the drug, Schleifer said, "When it's the president of the United States, of course, that gets obviously gets our attention."

"Presidential medicine is and has been unique," Arthur L. Caplan, professor of medical ethics at the N.Y.U. Grossman School of Medicine, toldThe Times. "If his doctors think an intervention might be helpful, and if that judgment is confirmed by outside experts they talk to and if things look dire or serious, then the president will get access to any and all agents."

Schleiferhas been a member atTrump's Westchester, N.Y., golf club,and his companytook$450 million in federalfunding this summer from Operation Warp Speed, which is the administration's moonshot projectto fast-trackCOVID-19 vaccines andtreatments, according toCNN Business.

"Len and President Trump are acquaintances from both living in the Westchester area for many years but didn't have any regular contact until this year, when they've discussed matters around COVID on occasion," a Regeneron spokesperson told CNN Business.

Schleifer is an active political donor, who predominantly gives to Democratic candidates. In 2016, Schleifergave more than $55,000 to committees supporting Hillary Clinton, but he has not yet donated to Democratic nominee Joe Biden, per FEC records. Hisson, Adam,lost a Democratic primary bid this summer for New York's 17th Congressional District.

"We don't share details on who has/hasn't submitted a compassionate use request, but as we've stated, only a small number of these requests have been approved forrareand exceptional circumstances, and that will continue to be the case," a Regeneron spokesperson told Salon in an email.

The spokesperson said the company was notaware of any side effectsoccurring in compassionate use cases and referred Salon to the FDA. The FDA did not reply to Salon's requests for comment.

In order to qualify for compassionate use, the FDA says, patients must meet a number of requirements: the disease or condition must be seriousor "immediately" life-threatening;there can be "no comparable or satisfactory alternative therapy to diagnose, monitoror treat the disease or condition"; clinical trials must be out of the question; potential benefitsmust justifypotential risks; and the treatment must not interfere with clinicaltrials that could supportproductdevelopment "or marketing approval for the treatment indication."

Given its extremely limited supply, Schleifer told CNBC that the international headlines put his company in a "very tough situation."

"Giving it to [Trump] or to others who might not be able or don't qualify for clinical trials is the right use of compassionate use. That's for small numbers of people, for these exceptions,"he said. "We want everybody to be potentially able to benefit. We understand we don't make that decision. This is a decision the FDA has to make."

Through no fault of Regeneron's own, however, the company may have harnessed one of the most powerful marketing platforms on the planet Trump's Twitter feed.

Fox News Geraldo Rivera criticizes Trump for not wearing a mask: "This disease kills old people!"

Kellyanne Conway curses out daughter in TikTok video: Youve lied about your own f*cking mother"

"They gave me Regeneron. It's called Regeneron," the president said in a Wednesday video published tohis feed, erroneouslynaming the drug company instead of its treatment."And other things, too. But I think this was the key. But they gave me Regeneron. And it was,like, unbelievable. I felt good immediately."

Trump claimed that he had "authorized" the treatment.However,it wasunclear what steps, if any, had been taken to expand its availabilityto more Americans.

More here:
Trump was one of the first 10 patients to get an experimental COVID-19 treatment under special use - Yahoo News

Posted in Maryland Stem Cells | Comments Off on Trump was one of the first 10 patients to get an experimental COVID-19 treatment under special use – Yahoo News

New toilet, a VR camera and science experiments are heading to t – KAKE

Posted: October 8, 2020 at 9:51 am

It successfully launched on an Antares rocket from Virginia Space's Mid-Atlantic Regional Spaceport at NASA's Wallops Flight Facility.

Toilets in space

Removing gravity from the equation means that nothing functions in space the way it does on Earth -- toilets included.

While the existing toilets are reliable, the new design is more user-friendly and easier to maintain, Morgan said.

The new compact toilet includes a funnel and hose for urine and a seat for bowel movements. In the absence of gravity, air flow pulls these away from the body.

The new design begins air flow automatically as soon as the lid is lifted on the toilet. This also helps control odor.

The new design is about 65% smaller and 40% lighter, with more efficient waste management and storage. This will come in handy as more crew members come to stay on the space station with the addition of the Commercial Crew Program, which can carry more astronauts in a single launch.

Astronaut feedback from using the existing toilets on the space station went into this new design, which is more ergonomic, requires less cleanup, is easier to maintain, has parts that are durable and is resistant to corrosion. The funnel and seat of this design can also be used simultaneously, which was incorporated

after feedback from female astronauts.

"The toilet is a great example of including all the feedback from various crewmembers," Meir said. "This better accounts for those, much easier for everyone to use up there."

The existing toilet was designed some time ago when there were few, if any, female astronauts staying on the space station. This design now better accounts for anatomical differences between men and women, Meir said.

Since water is a key factor of the life support systems on the space station, as well as those that will be used in future exploration of the moon and Mars, the astronauts' urine does not go to waste.

"We recycle about 90% of all water-based liquids on the space station, including urine and sweat," Meir said in a separate statement. "What we try to do aboard the space station is mimic elements of Earth's natural water cycle to reclaim water from the air. And when it comes to our urine on ISS, today's coffee is tomorrow's coffee!"

The toilet's urine transfer system will pretreat the urine and feed it into a regenerative system that recycles the water.

A second toilet like this will be installed in the Orion spacecraft to be used for the Artemis II flight test, which will send astronauts on a 10-day mission beyond the moon and back in 2023.

A virtual reality spacewalk

If you've ever watched astronauts conducting a spacewalk outside of the space station and wanted to know what it was like, a new camera will capture that experience in immersive 3D.

Felix & Paul Studios, helmed by creative directors Felix Lajeunesse and Paul Raphael, have partnered with the ISS National Lab in its ongoing "ISS Experience" virtual reality series. They previously sent up a camera in 2018 to document life inside the space station.

Now, the team, along with commercial partner Nanoracks, has modified a camera to withstand exposure to space and handle variable light exposure as the station passes through various sunrises and sunsets each day.

The camera will be mounted on the robotic arm Canadarm2 and film a spacewalk, from beginning to end, as well as the exterior of the space station and perspectives of the Earth.

These will be included in the final episodes of the series "Space Explorers: The ISS Experience." It will be available to watch on multiple platforms.

"This new EVA camera will enable that 3D immersive experience during a spacewalk," Meir said. "Spacewalks are the most challenging things that we do, both mentally and physically, and also the most exciting. You're out there in your own little spacecraft looking down on Earth with nothing between the void of space except for the thin visor of your helmet."

Meir participated in multiple spacewalks, including the first all-female spacewalk with fellow NASA astronaut Christina Koch in 2019.

Taking this camera outside of the space station after seeing the power of it inside the station will really make people feel like they're there, Morgan said. He also sees potential for the camera to be used as a way to train astronauts as they prepare for spacewalks.

When gravity isn't a factor

A variety of scientific experiments have taken place on the space station because the orbiting laboratory provides a unique environment that removes gravity as a factor.

One of the growing areas of research on the space station includes therapies for diseases like cancer.

Kernal Biologics is sending up an investigation that will use the microgravity environment to improve messenger RNA immunotherapy treatment for leukemia. Messenger RNA, or mRNA, is in all human cells to help create proteins, but it can differ in cancer cells compared to healthy cells.

Under the normal gravity conditions we experience on Earth, drugs tested for this are onco-selective, which means they can identify cancer cells from healthy cells and destroy the malignant cells. The microgravity environment of the space station can cause changes in mRNA. If these drugs are also effective in the microgravity environment, they could provide safer, more affordable and effective therapies for leukemia and other cancer treatments.

Other things are possible on the space station that simply can't happen on Earth, like cool diffusion flames. These flames, which burn at temperature below 752 degrees Fahrenheit, were first witnessed in an experiment on the space station in 2012. They don't exist on Earth.

"All flames have cool temperature chemistry that's going on," said Peter Sunderland, investigator of the experiment and a professor at the University of Maryland's A. James Clark School of Engineering. "Gravity is ubiquitous in combustion because hot gases rise, and a candle flame is narrow and tall. In microgravity, you get a much larger and spherical flame."

His experiment, funded by the National Science Foundation, could have implications for the efficiency of combustion engines and even help reduce emissions on Earth. During the investigation, researchers will look to observe spherical flames in microgravity to better understand the physics of cool diffusion flames.

Multiple experiments by students sponsored by the ISS National Lab also are included in the launch.

Researchers and graduate students at the University of Adelaide in Australia have an experiment that will help determine how microgravity and radiation impact the stability of pharmaceutical tablets. This will take place inside the space station, and a second experiment will occur in Alpha Space's MISSE (Materials International Space Station Experiment) Flight Facility on the exterior of the space station.

The University of Georgia is sending up its Spectral Ocean Color Satellite, a CubeSat, or miniaturized satellite, that can capture images used to monitor water quality and determine the health of ecosystems like coastal wetlands. Once it has arrived, this loaf-size satellite will launch from the space station on a Nanoracks deployer.

"The ISS National Lab takes great pride in working with our education and implementation partners to enable student researchers to take their science, engineering and technology questions to space far beyond their normal lab settings on Earth," said Michael Roberts, interim chief scientist at the Center for the Advancement of Science in Space and manager of the ISS National Lab.

"By collaboration with educators to support education projects on the space station, we hope to instill in students a lifelong interest in science and inspire them to pursue exciting career opportunities available in STEM fields."

See the article here:
New toilet, a VR camera and science experiments are heading to t - KAKE

Posted in Maryland Stem Cells | Comments Off on New toilet, a VR camera and science experiments are heading to t – KAKE

Oct. 7 – The radio show in my mind | Columnists | fwbusiness.com – FW Business

Posted: October 7, 2020 at 5:55 am

The president of the United States the leader of the free world, arguably the most powerful person on the planet has contracted a dangerous virus, and Im not sure how I should act.

Oh, I know very well what Im supposed to do. I must choose a side and root for my team from the sidelines. But how boisterous or subdued should I be, how enthusiastic or fretful?

The problem, I realize, is that Im missing the prompting Ive gotten used to. I need a cheerleader to give me the proper cues.

Like the ones I got when I briefly revisited the world of televised professional sports, after symbolically boycotting them for the intrusion of politics then actually missing them a little when they were adjourned sine die by the Trump-thumping virus.

Instead of making me endure the empty stadiums and eerie silence, the game enablers provided me with cardboard cutouts of fans in the stands and played recorded crowd noises. It helped me pretend I was watching something important that other people cared about rather than wasting my precious time on a frivolous, meaningless expenditure of testosterone.

And then there is the canned laughter that has been so instrumental in my enjoyment of situation comedies. I have never had to risk being wrong when I decided something was funny enough to be amusing. The chuckle machine showed me the way.

I notice the same laugh track has made an appearance at the return of Wheel of Fortune and Jeopardy! from their COVID-19 hiatus. I do not think an audience is there, since there are no longer panned shots of people applauding. But it sure sounds present and accounted for, snickering or guffawing at the hosts witticisms.

The people who are not there. Like the sounds that really arent there in the movies I watch on Netflix that I once would have left the house for. The click of high heels on linoleum. The whoosh of wind in the trees. The crackle of flames in the fireplace.

Theyre called Foley effects, invented for radio dramas to tickle the imagination. Sound-effects specialists would make bone-injury noises with frozen romaine lettuce, horse-hoof sounds with coconut shells, thunder with thin metal sheets, creaking doors with, well, creaking doors. When sound movies came along, so did the Foley artists to add depth and immediacy to the audio quality.

Reality enhanced. Reality augmented. Reality intensified. We could use that right now.

Donald Trump is, after all, the former reality show star, the first game show host ever elected to the highest office in the land. If were all just trapped inside the ultimate reality show, shouldnt we demand the ultimate thrill ride until the next commercial break?

Trumps opponents shouldnt have to settle for merely listening to the talking heads at CNN and MSNBC excoriating the president as a fool and a knave and a heartless, incompetent dictator who should just die as soon as possible, drooling and babbling in a virus-induced fever. There should be angry mob noises at the mere sound of his name, shouts and jeers and taunts and the Foley-created sounds of torches being lit and chains being rattled.

And his supporters shouldnt be content with just watching Fox News or listening to Rush Limbaugh to hear that Trump is the best president ever, achieving historic, world-shaking successes despite the obstructionist tactics of his evil, unpatriotic opponents who are little better than treasonous scum. There should be the sounds of champagne corks popping and the majestic strains of Hail to the Chief as the adoring multitudes prayerfully chant his name.

In the radio show of my mind, I can hear the teeth gnashing, see the hair pulling, feel the cynicism building to a boiling point. Just pick a side, my fans are shouting; tell us who you think is right and wrong. Youre not fooling anyone, my critics are sneering; we know which side youre really on when youre not pretending otherwise.

But, gentle readers, during such a grave moment, a potential turning point in our history, shouldnt we be able to bridge the partisan divide and unite to work together as one great American people on a common purpose with courage and understanding?

Cue wild applause, whistles, stomping of feet, heartfelt laughter and tears of joy, shouts of Way to go, champ! and Atta boy, Leo as America the Beautiful begins to play. Fade to commercial.

Leo Morris, columnist for The Indiana Policy Review, can be contacted at leoedits@yahoo.com.

Read the rest here:
Oct. 7 - The radio show in my mind | Columnists | fwbusiness.com - FW Business

Posted in Testosterone Shots | Comments Off on Oct. 7 – The radio show in my mind | Columnists | fwbusiness.com – FW Business

Page 875«..1020..874875876877..880890..»