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A Brief Guide to Genomics – National Human Genome Research Institute

Posted: May 17, 2023 at 12:13 am

Virtually every human ailment has some basis in our genes. Until recently, doctors were able to take the study of genes, or genetics, into consideration only in cases of birth defects and a limited set of other diseases. These were conditions, such as sickle cell anemia, which have very simple, predictable inheritance patterns because each is caused by a change in a single gene.

With the vast trove of data about human DNA generated by the Human Genome Project and other genomic research, scientists and clinicians have more powerful tools to study the role that multiple genetic factors acting together and with the environment play in much more complex diseases. These diseases, such as cancer, diabetes, and cardiovascular disease constitute the majority of health problems in the United States. Genome-based research is already enabling medical researchers to develop improved diagnostics, more effective therapeutic strategies, evidence-based approaches for demonstrating clinical efficacy, and better decision-making tools for patients and providers. Ultimately, it appears inevitable that treatments will be tailored to a patient's particular genomic makeup. Thus, the role of genetics in health care is starting to change profoundly and the first examples of the era of genomic medicine are upon us.

It is important to realize, however, that it often takes considerable time, effort, and funding to move discoveries from the scientific laboratory into the medical clinic. Most new drugs based on genome-based research are estimated to be at least 10 to 15 years away, though recent genome-driven efforts in lipid-lowering therapy have considerably shortened that interval. According to biotechnology experts, it usually takes more than a decade for a company to conduct the kinds of clinical studies needed to receive approval from the Food and Drug Administration.

Screening and diagnostic tests, however, are here. Rapid progress is also being made in the emerging field of pharmacogenomics, which involves using information about a patient's genetic make-up to better tailor drug therapy to their individual needs.

Clearly, genetics remains just one of several factors that contribute to people's risk of developing most common diseases. Diet, lifestyle, and environmental exposures also come into play for many conditions, including many types of cancer. Still, a deeper understanding of genetics will shed light on more than just hereditary risks by revealing the basic components of cells and, ultimately, explaining how all the various elements work together to affect the human body in both health and disease.

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Houston Integrative Medicine

Posted: May 17, 2023 at 12:13 am

First, we strongly believe in the value of preventative care, a concept grounded in traditional Chinese medicine. Brian Carter's Pulse of Oriental Medicine states the traditional Chinese doctor's job was to keep the village from getting sick and they in return would make sure his needs were met. Once they became sick, they were unable to take care of the doctor, therefore, it only made sense for him to keep them well. Our role is to keep you well before any signs of disease surface. By keeping mind, body and spirit in balance, maintaining appropriate nutrient levels and exercising a positive lifestyle, one is proactively taking care of themselves.

Second, we believe in natural healing. The body has an innate ability to heal itself, we simply assist you on your journey towards wellness. While western medication is effective at treating many illnesses, it can also act as a double-edged sword; the chemicals in pills and other drugs can have many potentially harmful side effects. Our doctors take a comprehensive look at your medical concerns and prescribe the healthiest solution that is individualized for your needs.

Third, the Center for Primary Care and Integrative Medicine seeks to reduce the increasingly prevalent abuse of narcotics. The United States consumes 60% of the world's narcotics and 99% of global Norco, and these are increasingly prescribed unnecessarily. This has adverse effects on the patient's body. More than 96,000 Americans and 4500 Texans died of drug overdoses in 2020 per CDC data. We should reduce their use as much as possible without compromising pain control. Today, more and more people are turning to natural methods of healing. The Center for Primary Care and Integrative Medicine incorporates the best of conventional and alternative medicine to provide the highest quality of care possible.

While preventing chronic disease has been our main focus of practice, we emphasize the importance of helping patients who already suffer from a variety of chronic diseases actively recover. In addition to regular cardiopulmonary rehab, we offer Taichi, massage, and acupuncture to help patients from a variety of chronic conditions, e.g., chronic Congestive Heart Failure, COPD, Parkinsons disease, etc., improve functional status. Studies have shown that acupuncture and Taichi can favorably affect heart rate variability and thus decrease post-myocardial infarct mortality. Acupuncture as adjunctive therapy can be used to alleviate chronic stable angina (JAMA intern Med. 2019;179 (10):1388-1397). Taichi-based cardiac rehabilitation was associated with an increase in peak oxygen consumption, a marker of functional capacity, in patients with recent MI. Acupuncture has been shown to reduce interleukin-17 (IL-17, inflammation marker) in asthmatic patients and increase 6 minute walking distance and quality of life in COPD patients. Recent studies, published in CHEST 2018; 153 (5): 116-1124, has shown that Tai Chi is equivalent to pulmonary rehab in improving functional status in COPD patients. Tai chi training has been shown to reduce balance impairments in patients with mild -to-moderate Parkinsons disease, with additional benefits of improved functional capacity and reduced falls (N Engl J Med 2012;366:511-9). Preliminary study has shown that Scalp acupuncture effectively slows down disease progress in Parkinsons disease patients and improve quality of life.

Last, but not least, we strive to reduce the cost of medicine for both individuals and the nation. Health care costs have been rising for several years and remains a focus of worldwide discussion. National health expenditures have doubled over the past decade from $1.3 trillion in 2000 to $2.6 trillion in 2010. It exceeded $ 4 trillion in 2020 according to Center for Medicare & Medicaid services (CMS). Total health care expenditures grew at an annual rate of 4.4 percent in 2008, outpacing inflation and the growth in national income. Indeed, we are a nation providing the best "sick" care. If we looked at replacing "sick" care with preventative medicine, we would be a healthier and wealthier nation. Spending on new medical technology and prescription drugs has been cited as a leading contributor to the increase in overall health. The Center for Primary Care and Integrative Medicine focuses on prevention and treatment of chronic diseases such as hypertension, diabetes, obesity, and chronic pain. Integrative medicine has been known to be highly effective in the treatment of such illnesses. In addition,the Center also gives consults to patients who want to learn taichi and yoga to improve well being.

Center for primary care and Integrative Medicine has also been actively collaborating with world renowned institutes to explore mechanisms underlying the effects of acupuncture, Ethnopharmacology, and the application of traditional Chinese Medicine in health regimen.

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What is integrative medicine (IM)? – Medical News Today

Posted: May 17, 2023 at 12:13 am

Integrative medicine (IM) is an approach that combines conventional medicine with complementary treatments. The aim of IM is to treat the whole person, not just a health problem.

Because IM is holistic, it can target the behavioral, social, and environmental aspects of a persons life as well as help treat the underlying health issue.

Many people are requesting more complementary therapies as part of their treatment plans, especially in certain health areas, such as cancer. That said, it is important to note that people should not replace their prescribed clinical treatments with complementary approaches alone, as this could lead to worse health outcomes.

Instead, people should discuss their current therapies with a doctor who can advise on the best course of treatment.

Read on to learn more about IM, including the risks, the benefits, and some of the conditions it may be useful for.

IM is a whole-person treatment plan that aims to treat the body, mind, and spirit. It specifically includes and coordinates the use of complementary therapies alongside conventional medicine.

Usually, a complementary therapy practitioner will suggest a combination of treatments to improve a persons well-being. For example, they may suggest that a person practices yoga to reduce stress but also recommend that they get in touch with an acupuncturist.

Practitioners tend to group complementary therapies into three key areas: nutritional, psychological, and physical.

Nutritional complementary therapies include products such as herbs, vitamin and mineral supplements, and probiotics. Supplements come in many forms, such as capsules, liquids, and powders. A person may also receive a specific diet plan.

A person should always speak with a doctor before taking any supplements in addition to their prescribed treatment. Doing so can cause certain interactions. For example, vitamin K can reduce the effectiveness of warfarin, which is a blood-thinning medication.

Psychological forms of complementary therapy aim to settle the mind and reduce stress. These therapies include:

There is a lot of overlap between mind and body practices. For example, although yoga and tai chi are physical practices, they also promote psychological well-being.

Learn more about types of meditation here.

Physical approaches to complementary health may include some form of muscle manipulation, such as massage. People may also receive treatment from a chiropractor, who can manipulate the spine to reduce pain or alleviate other health problems.

Alternatively, acupuncture is a physical treatment during which a practitioner inserts fine needles through the skin to stimulate specific pressure points.

Physical therapies that a person can try on their own or as part of a class include yoga and tai chi.

The use of integrative care is growing, especially in specialist cancer centers, where more people are requesting complementary approaches in addition to clinical treatments, such as chemotherapy.

In fact, one 2017 systemic review found that 45 National Cancer Institute treatment centers had increased the number of complementary treatments they offered on their websites over the course of 7 years, from 2009 to 2016. The most popular therapies included acupuncture, meditation, and yoga.

When a healthcare professional introduces complementary therapies as part of a persons treatment plan, the goal is usually to alleviate some side effects of conventional medicine.

For example, the authors of a 2018 meta-analysis note that acupuncture seems particularly effective at reducing fatigue in people with breast cancer who receive anticancer treatment.

However, an additional 2019 systematic review of studies that investigated the relationship between complementary therapies and cancer states that more robust study designs are necessary to fully understand the effectiveness of complementary therapies in an oncology environment.

Another area that may benefit from complementary therapy is fertility. One 2018 review suggests that females who practice Hatha yoga alongside other mind and body therapies may feel less stressed and anxious during in vitro fertilization treatment. Their psychosocial health may also improve.

Introducing IM may have some benefits. For example, a 2018 review notes that, overall, IM helps people deal with difficult illnesses and reduces their distress.

Furthermore, in some instances, IM may actually improve health outcomes. For example, a 2018 study based in South Korea found that when people received IM after experiencing a stroke, they had stronger survival rates at 3 and 12 months than those who received conventional medicine alone.

Although integrative care was more expensive, it prevented future hospital admissions, which can help hospitals save money in the long run.

People should be aware of the risks associated with some complementary approaches when including them in their treatment regimen.

The Food and Drug Administration (FDA) approves all conventional medications before manufacturers can sell them, but manufacturers of supplements do not need FDA approval to put their products on the market.

Additionally, some supplements can interact with some medications. This can increase the risk of complications if a person is also taking another medication.

It is also important that people do not view supplements and other herbal remedies as a cure or a replacement for conventional medication. If a manufacturer promotes its supplement as a cure, the product is likely unsafe.

Study design is also an important point that people should think about when researching the health benefits of some complementary therapies. Complementary health studies do not usually have robust study designs that other researchers can replicate, which means that the findings and conclusions could be inaccurate.

That said, the National Center for Complementary and Integrative Health is funding more studies to further investigate the health benefits of complementary therapies and how healthcare professionals can use them in addition to conventional medicine.

IM and alternative medicine are two terms that describe treatment that sits outside of conventional medical care.

If a person uses a nonconventional treatment option in a coordinated manner alongside conventional medicine, the practice is IM.

If a person uses a nonconventional treatment option instead of conventional medicine, the practice is alternative medicine.

Integrative medicine (IM) includes both complementary and conventional treatment approaches and specifically coordinates the use of the two as part of a holistic treatment plan.

Some benefits of IM include reducing distress and helping people process living with a difficult illness. Some healthcare professionals are expanding the use of IM, especially in the treatment of cancer.

Although researchers are taking a proactive attitude toward investigating the possible benefits of IM, studies that support complementary approaches often have design flaws, which means that their conclusions could be inaccurate.

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A Look Inside Stem Cells Helps Create Personalized Regenerative …

Posted: May 17, 2023 at 12:12 am

In two papers, researchers examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.

Nicholas Zhang, Georgia Tech Ph.D. candidate 

Organelles the bits and pieces of RNA and protein within a cell play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy. Organelle diversity in cells not only exists between cell types but also individual cells. Studying these differences helps researchers better understand cell function, leading to improved therapeutics to treat various diseases.

In two papers out of the lab of Ahmet F. Coskun, a Bernie Marcus Early Career professor in the Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University, researchers examined a specific type of stem cell with an intracellular toolkit to determine which cells are most likely to create effective cell therapies.

We are studying the placement of organelles within cells and how they communicate to help better treat disease, said Coskun. Our recent work proposes the use of an intracellular toolkit to map organelle bio-geography in stem cells that could lead to more precise therapies.

Creating the Subcellular Omics Toolkit

The first study published in Scientific Reports, a Nature portfolio journal looked at mesenchymal stem cells (MSCs) that have historically offered promising treatments for repairing defective cells or modulating the immune response in patients. In a series of experiments, the researchers were able to create a data-driven, single-cell approach through rapid subcellular proteomic imaging that enabled personalized stem cell therapeutics.

The researchers then implemented a rapid multiplexed immunofluorescence technique in which they used antibodies designed to target specific organelles. By fluorescing antibodies, they tracked wavelengths and signals to compile images of many different cells, creating maps. These maps then enabled researchers to see the spatial organization of organelle contacts and geographical spread in similar cells to determine which cell types would best treat various diseases.

Usually, the stem cells are used to repair defective cells or treat immune diseases, but our micro-study of these specific cells showed just how different they can be from one another, said Coskun. This proved that patient treatment population and customized isolation of the stem cells identities and their bioenergetic organelle function should be considered when selecting the tissue source. In other words, in treating a specific disease, it might be better to harvest the same type of cell from different locations depending on the patients needs.

RNA-RNA Proximity Matters

In the next study published this week in Cell Reports Methods, the researchers took the toolkit a step further, studying the spatial organization of multiple neighboring RNA molecules in single cells, which are important to cellular function. The researchers evolved the tool by combining machine learning and spatial transcriptomics. They found that analyzing the variations of gene proximity for classification of cell types was more accurate that analyzing gene expression only.

The physical interactions between molecules create life; therefore, the physical locations and proximity of these molecules play important roles, said Coskun. We created an intracellular toolkit of subcellular gene neighborhood networks in each cell's different geographical parts to take a closer look at this.

The experiment consisted of two parts: the development of computational methods and experiments at the lab bench. The researchers examined published datasets and an algorithm to group RNA molecules based on their physical location. This nearest neighbor algorithm helped determine gene groupings. On the bench, researchers then labeled RNA molecules with fluorescents to easily locate them in single cells. They then uncovered many features from the distribution of RNA molecules, such as how genes are likely to be in similar subcellular locations.

Cell therapy requires many cells with highly similar phenotypes, and if there are subtypes of unknown cells in therapeutic cells, researchers cannot predict the behavior of these cells once injected into patients. With these tools, more cells of the same type can be identified, and distinct stem cell subsets with uncommon gene programs can be isolated.

We are expanding the toolkit for the subcellular spatial organization of molecules a Swiss Army Knife for the subcellular spatial omics field, if you will, said Coskun. The goal is to measure, quantify, and model multiple independent but also interrelated molecular events in each cell with multiple functionalities. The end purpose is to define a cells function that can achieve high energy, Lego-like modular gene neighborhood networks and diverse cellular decisions.

This research is funded by Regenerative Engineering and Medicine at Georgia Tech, as well as the NSF Engineering Research Center for Cell Manufacturing Technologies (CMaT).

CITATION: Venkatesan, M., Zhang, N., Marteau, B., Yajima, Y., Ortiz De Zarate Garcia, N., Fang, Z., Hu, T., Cai, S., Ford, A. Olszewski, H., Borst, A., and Coskun, A. F. Spatial subcellular organelle networks in single cells.Scientific Reports13, 5374 (2023). doi.org/10.1038/s41598-023-32474-y

CITATION: Fang, Z., Ford, A., Hu, T., Zhang, N., Mantalaris, A., Coskun, A.F. Subcellular spatially resolved gene neighborhood networks in single cells. Cell Reports Methods. May 12, 2023. doi.org/10.1016/j.crmeth.2023.100476

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Artificial sweeteners dont aid weight loss, may increase diabetes, heart disease risk, says WHO – ThePrint

Posted: May 17, 2023 at 12:07 am

  1. Artificial sweeteners dont aid weight loss, may increase diabetes, heart disease risk, says WHO  ThePrint
  2. World Health Organization warns nonsugar sweeteners may increase risk of diabetes and heart disease  MarketWatch
  3. WHO: Artificial sweeteners linked to diabetes, death  POLITICO Europe

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How Does Gene Therapy Work? Types, Uses, Safety – Healthline

Posted: May 9, 2023 at 12:11 am

Gene therapy may have the potential to fix or replace genetic mutations, which are changes in your DNA that affect how your body works.

Doctors use gene therapy, also called gene editing to directly alter your genes.

This approach may help treat diseases caused by a single mutation, such as beta-thalassemia or spinal muscular atrophy (SMA). Gene editing may also help treat certain cancers.

Gene editing tools such as CRISPR-Cas9 are very new and are rapidly changing. Researchers continue to study their full potential along with any risks they may pose.

Heres what experts know so far about gene therapy.

Genes are small segments of DNA that instruct your cells to make certain proteins when specific conditions are met.

Mutated genes, on the other hand, may cause your cells to make too much or too little of the necessary protein. Even small changes can have a domino effect across your body just as tiny changes in computer code can affect an entire program.

Gene therapy can address this issue by:

Scientists dont have tweezers small enough to edit your DNA by hand. Instead, they recruit a surprising ally to work on their behalf: viruses.

Typically, a virus would enter your cells and alter your DNA to create more copies of itself. But scientists can switch out this programming with their own, hijacking the virus to heal instead of harm. These vectors, as theyre called, dont have the parts they need to cause disease, so they cant make you sick the way a regular virus could.

There are two types of gene therapy:

Each type has its own benefits:

Gene therapy is different from genetic engineering, which means changing otherwise healthy DNA for the purpose of enhancing specific traits. Hypothetically, genetic engineering could potentially reduce a childs risk of certain diseases or change the color of their eyes. But the practice remains highly controversial since it hovers very close to eugenics.

Gene therapy may be used to treat a variety of genetic conditions, including:

When the RPE65 gene in your retinas doesnt work, your eyeballs cant convert light to electrical signals.

The gene therapy Luxturna, approved by the Food and Drug Administration (FDA) in 2017, can deliver a functional replacement of the RPE64 gene to your retinal cells.

The FDA-approved Hemgenix can treat the bleeding disorder hemophilia B. The viral vector instructs your liver cells to create more of the factor IX protein, which helps your blood clot.

Meanwhile, the gene therapy Zynteglo, approved by the FDA in 2022, treats beta-thalassemia by giving your bone marrow stem cells correct instructions for creating hemoglobin.

This blood disorder can lower the oxygen in your body because it decreases your bodys hemoglobin production.

In infantile-onset SMA, an infants body cant make enough of the survival of motor neuron (SMN) proteins necessary to build and repair motor neurons. Without these neurons, infants gradually lose their ability to move and breathe.

The gene therapy Zolgensma, approved by the FDA in 2019, replaces faulty SMN1 genes in an infants motor cells with genes that can create enough SMN proteins.

Your ABCD1 gene produces an enzyme that breaks down fatty acids in your brain. If you have cerebral adrenoleukodystrophy, this gene is either broken or missing.

Skysona, FDA approved as of 2022, delivers a functional ABCD1 gene so that fatty acids dont build up and cause brain damage.

The FDA has approved gene therapies to treat multiple types of cancer, such as non-Hodgkins lymphoma and multiple myeloma.

Most cancer gene therapies work indirectly by inserting new genes into a powerful antibody called a T cell. Your changed T cells can then latch on to cancerous cells and eliminate them, similar to how they attack viruses.

The therapy Adstiladrin, approved by the FDA in 2022, can treat nonmuscle-invasive bladder cancer by altering the DNA in your bladder cells themselves.

Some people considering gene therapy may feel uneasy about putting viruses in their body.

Keep in mind, though, that gene therapies undergo extensive testing before approval. The viruses in gene therapies are also fixed so they cant replicate similar to many vaccines.

That said, gene therapies may pose other risks:

Despite these issues, experts generally believe gene therapy offers more benefits than risks.

Most of the conditions treated with gene therapy are life threatening. The dangers of leaving them untreated often outweigh the risks of potential side effects.

Gene therapy does come with a few drawbacks that keep it from becoming a widespread treatment.

Gene therapy can only target certain mutations. This means it may not work for everyone with a specific condition.

For example, two people may have inherited vision loss. Currently, gene therapy can only treat vision loss caused by the RPE64 mutation.

Because gene therapy research is so new, experts do extensive safety testing before introducing their treatments to the public. It can take years to get FDA approval for each new therapy.

As you might imagine, gene therapies are expensive to manufacture and administer. This not only affects funding for clinical trials but also the price of the drug.

For example, the gene therapy Zolgensma is the most expensive drug in the United States at $2.1 million per dose. Even with insurance, that kind of price tag remains out of reach for the average American.

Scientists are trying to find ways to make the development process safer, cheaper, and more efficient so more people can access gene therapy.

Gene therapy works to treat several different genetic diseases by editing the mutations that cause them. As researchers further refine and expand this technology, they may find even more conditions that could be treated with it.

Experts are also continuing to explore options to make gene therapy more affordable so people who need these treatments have an easier time getting them.

Emily Swaim is a freelance health writer and editor who specializes in psychology. She has a BA in English from Kenyon College and an MFA in writing from California College of the Arts. In 2021, she received her Board of Editors in Life Sciences (BELS) certification. You can find more of her work on GoodTherapy, Verywell, Investopedia, Vox, and Insider. Find her on Twitter and LinkedIn.

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Revolution Medicines Reports First Quarter 2023 Financial Results and Update on Corporate Progress

Posted: May 9, 2023 at 12:10 am

First Wave of Investigational RAS(ON) Inhibitors – RMC-6236 (RASMULTI), RMC-6291 (KRASG12C) and RMC-9805 (KRASG12D) – progressing on plan

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Shockwave Medical Reports First Quarter 2023 Financial Results

Posted: May 9, 2023 at 12:10 am

SANTA CLARA, Calif., May 08, 2023 (GLOBE NEWSWIRE) -- Shockwave Medical, Inc. (Nasdaq: SWAV), a pioneer in the development and commercialization of Intravascular Lithotripsy (IVL) to treat complex calcified cardiovascular disease, today reported financial results for the three months ended March 31, 2023.

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Vaxcyte Reports First Quarter 2023 Financial Results and Provides Business Update

Posted: May 9, 2023 at 12:10 am

-- Positive Data from VAX-24 Phase 2 Study in Adults Aged 65 and Older Demonstrated Robust Immune Responses Across all 24 Serotypes (ST) at all Doses, Confirming Prior Phase 2 Results in Adults Aged 50-64 ---- Full Six-Month Safety Data from Both Adult Studies Demonstrated VAX-24 Safety and Tolerability Results Similar to PCV20 at All Doses Studied --

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Coherus BioSciences Reports First Quarter 2023 Financial Results and Business Highlights

Posted: May 9, 2023 at 12:10 am

– UDENYCA® autoinjector approved and ready for May 2023 launch –– CIMERLI® product-specific Q-code now facilitating electronic reimbursement following April 1 activation –– FDA inspection of toripalimab manufacturing site scheduled for May 2023 –– Toripalimab launch anticipated in Q3 2023, if approved –– YUSIMRY™ ready for planned July 2023 launch –– FDA review of UDENYCA® OBI BLA supplement progressing; launch anticipated in 2023, if approved –– Net product revenue of $32.4 million in the first quarter 2023 –– Conference call today at 5:00 p.m. Eastern Time –

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