Page 903«..1020..902903904905..910920..»

Dr. Andreas Sauerbrey: The right orthopaedic diagnosis is essential to proper care – Sky Hi News

Posted: September 12, 2020 at 9:53 pm

Dr. Andreas Sauerbrey believes the most important factor in getting efficient and correct orthopaedic treatment is having the right diagnosis.

You need to come to a specialist who can give you the options for that diagnosis, he said.

Dr. Sauerbrey, who specializes in shoulder and upper-extremity surgery, sports medicine, and joint restoration at Steamboat Orthopaedic and Spine Institute (SOSI), is proud of the access the institute provides to so many fellowship-trained surgeons. This extra level of training and experience provides the community with orthopaedic care that is truly world class.

When you come to see us, youll get the right diagnosis, but it doesnt mean you have to have surgery, he said.

Shoulder, elbow and hand

Dr. Sauerbrey is fellowship trained in shoulder and elbow surgery from the University of Pennsylvania and in hand surgery from Thomas Jefferson University in Philadelphia. He also holds a Sports Medicine Specialty Certificate.

Dr. Sauerbrey is particularly skilled in shoulder arthroscopy and reconstruction, and biologic treatments such as platelet-rich plasma (PRP) and growth factors.

For the past 20 years, Dr. Sauerbrey has performed 300 to 400 shoulder surgeries annually. He does just about every orthopaedic procedure, including knee and hip replacements, but about 60% of his work focuses on shoulders.

People have options within our practice, he said. If they dont come see me, they should see one of my partners. Theres really no reason to go out of town.

A progressive approach

Dr. Sauerbrey has been performing PRP injections since 2008. Hes particularly enthusiastic about how biomedicine has evolved in orthopaedic medicine during that time.

The biggest changes in orthopaedic medicine have been in biologics its just blown up in the last 10 years, he said.

Dr. Sauerbrey works with some of the most advanced orthopaedic companies to deliver the latest methods and treatments, which include PRP and stem cells.

The companies we use are very progressive, surgeon-driven, constantly innovating, he says. Its remarkable how much is out there, and SOSI offers it all.

PRP, the most popular injection, releases growth factors that trick the body into creating a healing response. Dr. Sauerbrey says he frequently does PRP injections in knees, shoulders and elbows. While its not going to fix mechanical injuries (such as an ACL tear), PRP, when used in the right context, can relieve pain and improve mobility.

My intention is to bring state-of-the-art medicine to Steamboat in an efficient and affordable way, he said. Together, we ensure the latest, most innovative technology available for both operative and non-operative procedures. We believe patients and their families should have the best care possible at all times.

Destined for orthopaedics

Dr. Sauerbreys brain was always mechanically oriented, so its no surprise he chose a medical field that would allow him to practice that skill on the human body.

Being good with your hands you either have it or you dont, he said. For me, it probably goes back to the days of wrenching on cars with my dad.

One of the first major decisions that medical students make about their future careers is whether they will become surgeons. For Sauerbrey, that happened by his second year of medical school. Having a mother who worked as an orthopaedic nurse for 20 years and getting the mechanical practice he did while working with his father, Sauerbrey was practically destined to become an orthopaedic surgeon.

I knew I had to do procedures, he said. Once you decide that, it eliminates half the field of potential specialties.

Community driven

With a belief that good health care should never be hard to find, Dr. Sauerbrey has committed himself to building an orthopaedic practice that puts the community first. Most of the SOSI physicians have been practicing in Yampa Valley for many years, and thats a testament to their high quality of care.

You cannot survive in a community like this if youre not doing a good job its not going to happen, he says. Youre operating on your friends and neighbors, and you have to be comfortable with that.

With an extremely active and motivated population that demands to be fixed back up so that they can return to their beloved outdoor activities, theres a real motivation to help patients get through their injuries and come out stronger on the other side.

We fix people so they can go back to what they love, Dr. Sauerbrey said. Were accountable socially here in Steamboat.

Read the original post:
Dr. Andreas Sauerbrey: The right orthopaedic diagnosis is essential to proper care - Sky Hi News

Posted in Pennsylvania Stem Cells | Comments Off on Dr. Andreas Sauerbrey: The right orthopaedic diagnosis is essential to proper care – Sky Hi News

Brighton researchers lead study on genetics and asthma – The Argus

Posted: September 12, 2020 at 12:58 am

A STUDY has shown for the first time that genetics may play a part in how well children respond to treatment for asthma.

Researchers at Brighton and Sussex Medical School (BSMS) say their findings indicate that childrens asthma symptoms could be better controlled with personalised treatments.

Dr Tom Ruffles, honorary consultant in paediatric respiratory medicine, worked with a study team led by Professor Somnath Mukhopadhyay, chairman in paediatrics at the Royal Alexandra Childrens Hospital and BSMS.

Dr Ruffles and Professor Mukhopadhyay presented the results from their trial at the virtual European Respiratory Society International Congress.

According to Dr Ruffles, asthma affects one in 11 children in the UK and a child is admitted to hospital because of their asthma every 18 minutes.

He told the conference: Asthma is a common condition in children that causes coughing, wheezing and difficulty breathing.

We have a number of medicines that are generally effective in treating children with asthma, but they dont work equally well for all children.

We think that genetic differences could have an effect on whether these medicines work and thats what we wanted to examine in this study.

Previous research suggests the majority of children with asthma will benefit from standard treatment with a medicine called salmeterol and their regular steroid inhaler.

However about one in seven children have a small genetic difference which means using this medication could actually result in them having more asthma symptoms.

The BSMS study involved 241 young people aged between 12 and 18 who were all being treated for asthma.

Participants were randomly assigned either to receive treatment according to existing guidelines, or treatment according to particular genetic differences their genotype an approach known as personalised medicine.

Children in the personalised medicine group were treated with an alternative asthma medicine called montelukast.

Researchers followed the children for a year to monitor their quality of life, with a score between one and seven according to how their symptoms were and whether their normal activities were limited by their asthma.

They found that for children with a particular gene who were given personalised treatment, they experienced an improvement in their quality of life score.

Professor Mukhopadhyay said: These results are very promising because they show for the first time, that it could be beneficial to test for certain genetic differences in children with asthma and select medication according to those differences. In this study we saw only a modest effect, but this may be partly because the childrens asthma was generally very well controlled and only a few children experienced any serious symptoms during the 12-month period.

Larger trials, with a focus on those with poorer asthma control, may help us determine the true benefit for children of prescribing in this way.

Excerpt from:
Brighton researchers lead study on genetics and asthma - The Argus

Posted in Genetics | Comments Off on Brighton researchers lead study on genetics and asthma – The Argus

Invitae Appoints Kimber Lockhart to its Board of Directors – BioSpace

Posted: September 12, 2020 at 12:58 am

SAN FRANCISCO, Sept. 11, 2020 /PRNewswire/ --Invitae Corporation (NYSE: NVTA), a leading medical genetics company, today announced the appointment of Kimber Lockhart to its Board of Directors, effective September 10, 2020.

"We are excited to welcome Kimber Lockhart to our board of directors, bringing expertise in scaling fast-growth businesses that will provide valuable insight as we continue to grow," said Sean George, co-founder and chief executive officer of Invitae. "Her expertise as a product, engineering and infrastructure leader, combined with her perspective on leveraging technology to improve healthcare for patients, will be a valuable addition to our board as we continue to pursue our mission to bring genetics to mainstream medicine to improve healthcare for billions of people around the world."

"I'm happy to join the board of directors at Invitae at this exciting time in the company's continued growth," said Lockhart. "Invitae's approach is unique and the company's capabilities combined with its dedication to its mission to make comprehensive genetic information services widely available has the potential to transform healthcare for patients worldwide."

Lockhart is an experienced technology leader, scaling technology platforms to support rapid business growth. Since 2015, Lockhart has served as chief technology officer at One Medical, a national leader in technology-enabled primary care, where she was previously vice president of engineering from 2014 to 2015. Prior to joining One Medical, Lockhart served in various engineering leadership roles at online file-sharing service Box from 2009 to 2014. Previously, Lockhart was co-founder and CEO of Increo Solutions, provider of document rendering and collaboration technologies, which was acquired by Box in 2009. She holds a B.S. in Computer Science from Stanford University.

About Invitae

Invitae Corporation (NYSE: NVTA) is a leading medical genetics company whose mission is to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Invitae's goal is to aggregate the world's genetic tests into a single service with higher quality, faster turnaround time, and lower prices. For more information, visit the company's website atinvitae.com.

Contact:Laura D'Angeloir@invitae.com(628) 213-3369

View original content to download multimedia:http://www.prnewswire.com/news-releases/invitae-appoints-kimber-lockhart-to-its-board-of-directors-301128086.html

SOURCE Invitae Corporation

View post:
Invitae Appoints Kimber Lockhart to its Board of Directors - BioSpace

Posted in Genetics | Comments Off on Invitae Appoints Kimber Lockhart to its Board of Directors – BioSpace

BRCA1 and BRCA2 Gene Mutations: I Have a Mutation, What Are My Options? – University of Michigan Health System News

Posted: September 12, 2020 at 12:58 am

If a patient learns that they do carry a mutation in their BRCA1 or BRCA2 genes, a genetic counselor can discuss potential options with them.

A common option for women is to undergo increased screening, including getting a breast exam from a health care provider every six months, and also a yearly mammogram and breast MRI.

There are also medications that people with BRCA gene mutations can take to reduce the risk of developing breast cancer, she says.

Doctors call these medications chemoprevention, but that makes it sound like chemotherapy, which its not, Milliron says. It is a medication that you do take for several years, and I think it's really important to have that discussion about the pros and cons and what to expect with a specialized health care provider. Women have to be at least age 35 and finished with family planning before they can consider taking a medication to reduce the risk of developing breast cancer because there is a risk of causing birth defects.

The medication that is usually given to premenopausal women is called tamoxifen, and studies point to more clear benefit for women with BRCA2 mutations. There are additional, related medications that are usually prescribed to postmenopausal women if tamoxifen is not a good option for those women.

MORE FROM MICHIGAN: Sign up for our weekly newsletter

Some women chose to have both breasts removed a prophylactic/risk reducing bilateral mastectomy which has been shown to reduce the risk of developing breast cancer by about 90% to 95%, Milliron notes.

This is obviously a very, very personal choice, Milliron says. If you look at the statistics of the women who choose increased screening with mammogram and breast MRI, and the women who choose risk reducing or prophylactic bilateral mastectomy, there is no difference in the chance of passing away from breast cancer between those two groups. So that is something that I think is very important for patients to know and to understand.

These decisions can be influenced by watching family or friends go through cancer treatment, as can family dynamics as well as cultural and religious considerations, she adds.

Ovarian cancer is a different story than breast cancer, however.

I've been a genetic counselor for 22 years, and that is the only thing that has not yet changed about my job is that we still do not have a screening tool for ovarian cancer that works, Milliron says. So for a woman who has a BRCA1 gene mutation, we usually talk about having the ovaries and the fallopian tubes removed between 35 and 40. And then for a woman who has a BRCA2 gene mutation, we usually talk about having them removed between 45 and 50.

While the statistics vary slightly between studies, research shows this surgery can reduce the risk of developing ovarian cancer and fallopian tube cancer by 80 to 95%.

Birth control pills are also a potential option for women with these mutations to reduce their risk of developing ovarian cancer.

That may influence their breast cancer risk, however, so that's a conversation that we have to have, Milliron adds.

Men who carry a BRCA1 or BRCA2 gene mutation, are at increased risk for prostate cancer. And these can be more aggressive and develop at younger ages. For them increased screening starting about age 40 to 45 is recommended, including prostate-specific antigen, commonly referred to as PSA, testing and a digital rectal exam yearly.

The Rogel Cancer Center is very lucky to have a prostate cancer risk assessment clinic, Milliron says. So many times men are somewhat forgotten in the BRCA1, BRCA2 picture.

You can learn more about cancer genetics on the Rogel Cancer Centers website.

See the rest here:
BRCA1 and BRCA2 Gene Mutations: I Have a Mutation, What Are My Options? - University of Michigan Health System News

Posted in Genetics | Comments Off on BRCA1 and BRCA2 Gene Mutations: I Have a Mutation, What Are My Options? – University of Michigan Health System News

Rock snot discovered in another Pennsylvania waterway – pennlive.com

Posted: September 12, 2020 at 12:56 am

Rock snot, an invasive aquatic alga, has been discovered in another Pennsylvania stream.

According to the Pennsylvania Fish and Boat Commission, Didymospheria geminata has been confirmed in Quemahoning Creek in Somerset County.

The algae has been dubbed rock snot because of its appearance when wet. When squeezed dry, the tan to greenish beige alga feels like moist cotton or wool.

Didymo does not present a public health hazard, but it can cause ecological damage by smothering other organisms which also live on the riverbed and support the food web for the resident fish community.

In response to the discovery, the commission and the Pennsylvania Department of Environmental Protection have reminded anglers and boaters that cleaning their gear is the easiest, most effective means to prevent its spread to other waters.

We may not be able to eliminate didymo from infected waterways, but there are things we can do to slow or prevent its spread to other waters, said Heather Smiles, chief of the commissions Division of Environmental Services.

Didymo cells can easily be carried downstream and can be picked up by any items or equipment in contact with infected water including fishing tackle, waders, recreational equipment, boats and trailers.

It takes just one live didymo cell to start a new colony of the alga.

The commission urges anglers and boaters to clean their gear before leaving a water body and allow it to dry completely before entering another water. After equipment is dry to the touch, allow to dry another 48 hours.

Thick and dense material such as life jackets or felt-soled wading gear will hold moisture longer, take longer to dry and can be more difficult to clean.

Soaking equipment in hot water containing dishwashing detergent (2 cups of detergent for every 2.5 gallons of water) for 20 minutes or more also will kill didymo. If hot water is not available, a commercial hot-water car wash also makes a good location to wash boats, motors and trailers.

At the other end of the temperature range, freezing items solid for at least 24 hours is effective.

If cleaning, drying or freezing is not practical, the commission suggests that the equipments use be limited to a single waterway.

The section of Quemahoning Creek where the alga was found provides fishing opportunities for stocked trout as well as warm-water and cool-water fish. The commission annually stocks fingerling brown and rainbow trout.

Since 2007 didymo has been detected in the West Branch and main stem of the Delaware River, Dyberry Creek in Wayne County, Youghiogheny River watershed in Fayette County and Pine Creek in Lycoming County.

Question about nature or the outdoors? Contact Marcus Schneck at mschneck@pennlive.com.

See the article here:
Rock snot discovered in another Pennsylvania waterway - pennlive.com

Posted in Delaware Stem Cells | Comments Off on Rock snot discovered in another Pennsylvania waterway – pennlive.com

School of Science grows by 10 – MIT News

Posted: September 10, 2020 at 4:58 pm

Despite the upheaval caused by the coronavirus pandemic, 10 new faculty members have joined MIT in the departments of Biology; Chemistry; Earth, Atmospheric and Planetary Sciences; Mathematics; and Physics. The School of Science welcomes these new faculty, most of whom began their appointment July 1, amidst efforts to update education and research plans for the fall semester. They bring exciting and valuable new areas of strength and expertise to the Institute.

Camilla Cattania is an earthquake scientist. She uses continuum mechanics, numerical simulations, and statistics to study fault mechanics and earthquake physics at different scales, from small repeating events to fault interaction on regional and global scales. The models she has developed can help forecast earthquake sequences caused by seismic or aseismic events, such as aftershocks and swarms induced by forcing mechanisms like magma moving under the Earths surface. She has also developed theoretical models to explain why certain faults rupture in predictable patterns while others do not. Cattanias research plans include widening her focus to other tectonic settings and geometrically complex fault structures.

Cattania earned her bachelors and masters degrees from Cambridge University in experimental and theoretical physics in 2011, after which she completed a PhD in Germany at the GFZ German Research Center for Geosciences and the University of Potsdam in 2015. Subsequently, she spent a few months as a researcher at Woods Hole Oceanographic Institution and as a postdoc at Stanford University and her doctoral institution. She joins the Department of Earth, Atmospheric and Planetary Sciences as an assistant professor.

Richard Fletcher researches quantum physics using atomic vapors one-millionth the density of air and one-millionth the temperature of deep space. By manipulating the gas with intricately sculpted laser beams and magnetic fields, he can engineer custom-made quantum worlds, which provide both a powerful test bed for theory and a wonderful playground for discovering new phenomena. The goal is to understand how interesting collective behaviors emerge from the underlying microscopic complexity of many interacting particles. Fletchers interests include superfluidity in two-dimensional gases, methods to probe the correlations between individual atoms, and how the interplay of interactions and magnetic fields leads to novel physics.

Fletcher is a graduate of Cambridge University, where he completed his bachelor's in 2010. Before returning to Cambridge University to earn his PhD in 2015, he was a research fellow at Harvard University. He originally came to MIT as a postdoc in 2016 and now joins the Department of Physics as an assistant professor. Fletcher is a member of the MIT-Harvard Center for Ultracold Atoms.

William Frank investigates deformation of the Earths crust. He combines seismology and geodesy to explore the physical mechanisms that control the broad continuum of rupture modes and fault instabilities within the Earth. His research has illuminated the cascading rupture dynamics of slow fault slip and how the aftershocks that follow a large earthquake can reveal the underlying behavior of the host fault. Frank considers shallow shifts that cause earthquakes down to deep creep that is all-but-invisible at the surface. His insights work to improve estimates of seismic hazards induced by tectonic dynamics, volcanic processes, and human activity, which can then inform risk prediction and mitigation.

Frank holds a bachelors degree from the University of Michigan in earth systems science, which he received in 2009. The Institut de Physique du Globe de Paris awarded him a masters degree in geophysics in 2011 and a PhD in 2014. He first joined MIT as a postdoc in 2015 before moving to the University of Southern California as an assistant professor in 2018. He now returns as an assistant professor in the Department of Earth, Atmospheric and Planetary Sciences.

Ronald Fernando Garcia Ruizadvances research on fundamental physics and nuclear structure largely through the development of novel laser spectroscopy techniques. He investigates the properties of subatomic particles using atoms and molecules made up of short-lived radioactive nuclei. Garcia Ruizs experimental work provides unique information about the fundamental forces of nature and offers new opportunities in the search beyond the Standard Model of particle physics. His previous research at CERN focused on the study of the emergence of nuclear phenomena and the properties of nuclear matter at the limits of existence.

Garcia Ruizs bachelors degree in physics was achieved in 2009 at Universidad Nacional de Colombia. After earning a masters in physics in 2011 at Universidad Nacional Autnoma de Mxico, he completed a doctoral degree in radiation and nuclear physics at KU Leuven in 2015. Prior to joining MIT, he was first a research associate at the University of Manchester from 2016-17 and then a research fellow at CERN. Garcia Ruiz has now joined the Department of Physics as an assistant professor. He began his appointment Jan. 1. He is also affiliated with the Laboratory for Nuclear Science.

Ruth Lehmann studies germ cells. The only cells in the body capable of producing an entire organism on their own, germ cells pass genomic information from one generation to the next via egg cells. By analyzing the organization of their informational material as well as the mechanics they regulate, such as the production of eggs and sperm, Lehmann hopes to expose germ cells unique ability to enable procreation. Her work in cellular and developmental biology is renowned for identifying how germ cells migrate and lead to the continuation of life. An advocate for fundamental research in science, Lehmann studies fruit flies as a model to unveil vital aspects of early embryonic development that have important implications for stem cell research, lipid biology, and DNA repair.

Lehmann earned her bachelors degree in biology from the University of Tubingen in Germany. She took an interlude from her education to carry out research at the University of Washington in the United States before returning to Germany. There, she earned a masters equivalent from the University of Freiburg and a PhD from the University of Tubingen. Lehmann was subsequently a postdoc at the Medical Research Council Laboratory of Molecular Biology in the UK, after which she joined MIT. A faculty member and Whitehead Institute for Biomedical Research member from 1988 to 1996, she now returns after 23 years at New York University. Lehmann joins as a full professor in the Department of Biology and is the new director of the Whitehead Institute forBiomedical Research.

As an astrochemist, Brett McGuire is interested in the chemical origins of life and its evolution. He combines physical chemistry experiments and analyses with molecular spectroscopy in a lab, the results of which he then compares against astrophysics observation. His work ties together questions about the formation of planets and a planets ability to host and create life. McGuire does this by investigating the generation, presence, and fate of new molecules in space, which is vast and mostly empty, providing unique physical challenges on top of chemical specifications that can impact molecular formation. He has discovered several complex molecules already, including benzonitrile, a marker of carbon-based reactions occurring in an interstellar medium.

McGuires BS degree was awarded by the University of Illinois at Urbana-Champaign in 2009. He completed a masters in physical chemistry in 2011 at Emory University and a PhD in 2015 at Caltech. He then pursued a postdoc at the National Radio Astronomy Observatory and the Harvard-Smithsonian Center for Astrophysics. He joins the Department of Chemistry as an assistant professor.

Dor Minzer works in the fields of mathematics and theoretical computer science. His interests revolve around computational complexity theory, or more explicitly probabilistically checkable proofs, Boolean function analysis, and combinatorics. With collaborators, he has proved the 2-to-2 Games Conjecture, a central problem in complexity theory closely related to the Unique-Games Conjecture. This work significantly advances our understanding of approximation problems and, in particular, our ability to draw the border between computationally feasible and infeasible approximation problems.

Minzer is not new to online education. After earning his bachelors degree in mathematics in 2014 and a PhD in 2018, both from Tel-Aviv University, he became a postdoc at the Institute for Advanced Study in Princeton, New Jersey. He joins the Department of Mathematics as an assistant professor.

Lisa Piccirillo is a mathematician specializing in the study of three- and four-dimensional spaces. Her work in four-manifold topology has surprising applications to the study of mathematical knots. Perhaps most notably, Piccirillo proved that the Conway knot is not "slice." For all other small knots, "sliceness" is readily determined, but this particular knot had remained a mystery since John Conway presented it in the mid-1900s. After hearing about the problem at a conference, Piccirillo took only a week to formulate a proof. She is broadly interested in low-dimensional topology and knot theory, and employs constructive techniques in four-manifolds.

Piccirillo earned her BS in mathematics in 2013 from Boston College. Her PhD in mathematics was earned from the University of Texas at Austin in 2019, and from 2019-20 she was a postdoc at Brandeis University. She joins the Department of Mathematics as an assistant professor.

Jonathan Weissmans research interest is protein folding and structure, an integral function of life. His purview encompasses the expression of human genes and the lineage of cells, as well as protein misfolding, which can cause diseases and other physiological issues. He has made discoveries surrounding protein folding mechanisms, the development of CRISPR gene-editing tools, and other new therapeutics and drugs, and in the process generated innovative experimental and analytical methods and technologies. One of his novel methods is the ribosome profiling approach, which allows researchers to observe in vivo molecular translation, the process by which a protein is created according to code provided by RNA, a major advancement for health care.

Weissman earned a bachelors degree in physics from Harvard University in 1998 and a PhD from MIT in 1993. After completing his doctoral degree, he left MIT to become a postdoc at Yale University for three years, and then a faculty member at the University of California at San Francisco in 1996. He returns to MIT to join the Department of Biology as a full professor and a member of the Whitehead Institute for Biomedical Research. He is also a Howard Hughes Medical Institute investigator.

Yukiko Yamashita, a stem cell biologist, delves into the origins of multicellular organisms, asking questions about how genetic information is passed from one generation to the next, essentially in perpetuity, via germ cells (eggs and sperm), and how a single cell (fertilized egg) becomes an organism containing many different types of cells. The results of her work on stem cell division and gene transmission has implications for medicine and long-term human health. Using fruit flies as a model in the lab, she has revealed new areas of knowledge. For example, Yamashita has identified the mechanisms that enable a stem cell to produce two daughter cells with distinct fates, one a stem cell and one a differentiating cell, as well as the functions of satellite DNA, which she found to be crucial, unlike the waste they were previously thought to be.

Yamashita received her bachelors degree in biology in 1994 and her PhD in biophysics in 1999, both from Kyoto University. After being a postdoc at Stanford University for five years, she was appointed a faculty member at the University of Michigan in 2007. She joined the Department of Biology as a full professor with a July 1 start. She also became a member of the Whitehead Institute of Biomedical Research and is a standing investigator at the Howard Hughes Medical Institute.

The rest is here:
School of Science grows by 10 - MIT News

Posted in Michigan Stem Cells | Comments Off on School of Science grows by 10 – MIT News

COVID-19 Drug Discovery and Development Why Diverse Strategies Are Critical – Technology Networks

Posted: September 10, 2020 at 4:58 pm

There is no silver bullet at the moment, and there might never be, said World Health Organization Director-General Tedros Adhanom at a virtual press conference at the beginning of August. While it was this bleak sound bite that made the headlines, Tedros also had words of praise for the progress made towards identifying treatments that aid the recovery of COVID-19 patients with the most serious forms of the disease.Research towards treatments for COVID-19 has been developing at a phenomenal speed, even though it feels as though solutions cant come soon enough; the widespread transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had significant health, economic and social impacts across the globe, and as of September 8th more than 27 million cases and 890,000 deaths have been recorded in 188 countries.

Research groups across the world have set about identifying drugs for the treatment of COVID-19, by screening both novel and existing drugs for their ability to alleviate symptoms and stem viral replication. Here, we provide an update on ongoing global efforts to develop and test drugs for the treatment of COVID-19 and explore the range of strategies being employed.

COVID-19 is a disease which can leave you with anything between a mild sniffle to an unpleasant combination of high fever, heavy fatigue, and lung inflammation and damage. The drivers of clinical symptoms can be roughly divided into two categories: the virus itself and the hyperinflammatory response to the virus that occurs in the most severely ill people. Consequently, efforts to identify appropriate treatments are often focused on one category, and sometimes, a particular patient group or stage of disease. Given the nature of COVID-19, it is highly likely that a combination of drugs (drug cocktail) will be needed to both neutralize the virus and suppress the symptoms of COVID-19. Antiviral treatments may target viral components directly, or other cellular processes involved in viral infection or replication. To date, interventional studies for COVID-19 have attempted to achieve a wide range of goals, including:

Addressing the threat of new and potentially life-threatening pathogens requires deep understanding and accurate, reproducible techniques for developing better tests, vaccines, and treatments. Agilent provides the complete breadth of systems, consumables, software, services, and knowledge you need to support your success.

Sponsored Content

Meet the scientists on the frontline with coronavirus. Video credit: Sanford Burnham Prebys Medical Discovery Institute

Of the ~12,000 compounds screened, 100 inhibited SARS-CoV-2 replication in mammalian cells, 21 of which did so in a dose-response fashion. Achieving a sufficiently high dose concentration to elicit antiviral effects in vivo was predicted to be practical and possible for 13 of these compounds based on EC50 values in various cell lines. The most potent of these were evaluated for antiviral activity in human induced pluripotent stems cell (iPSC)-derived pneumocyte-like cells (five candidates) and in an ex vivo lung culture system (one candidate). The latter candidate is called apilimod, a small molecule inhibitor of an enzyme (phosphoinositide 5-kinase or PIKfyve, an endosomal lipid kinase) important to the endocytic pathway in which SARS-CoV-2 travels along during its journey through the cell. Encouragingly, apilimod potently antagonized viral replication in these tissues, and the findings are in agreement with those of another research group. This month, Kang et al. published an article in PNAS, describing the potent inhibition of SARS-CoV-2 by apilimod, providing further evidence to suggest PIKfyve-inhibition as a potential strategy that could limit infection and disease pathogenesis. The authors also noted that apilimod has passed safety tests in previous clinical trials for nonviral indications.

Chanda highlights the incredible pace at which this work was produced. Typically, a project like this would take years, rather than months. He points out that by wanting to do something quickly, there were sacrifices (and not just weekends). For example, they ran with the assay and the cell lines that allowed them to produce results quickly. This is the reason we put the entire dataset out there not one/three/20 molecules, we put all 100 molecules out there. These are the ones we found because of our experimental system, but please keep testing the others because youll probably find other things that work, said Chanda.

To design multiple peptide sequences that can competitively bind to the SARS-CoV-2 receptor binding domain, the University of Michigan research group used a protein design system called EvoDesign.EvoDesign is the first de novo protein design protocol developed in our lab; it performs design simulation by combining the evolution-based information collected from protein databases and an accurate physics- and knowledge-based energy function, namely EvoEF2, for computing atomic interactions such as van der Waals forces, electrostatics, hydrogen bonding, and desolvation energies, said Huang.

Overall, these sophisticated computational tools represent a promising new avenue for the de novo development of drug discovery studies.

Michele Wilson is a freelance science writer for Choice Science Writing.

Read more here:
COVID-19 Drug Discovery and Development Why Diverse Strategies Are Critical - Technology Networks

Posted in Michigan Stem Cells | Comments Off on COVID-19 Drug Discovery and Development Why Diverse Strategies Are Critical – Technology Networks

Cancer Stem Cells Market is Thriving Worldwide 2020-2027 | Top Companies Merck KGaA, ONCOMED PHARMACEUTICALS INC, Bionomics, MacroGenics, Inc.,…

Posted: September 9, 2020 at 3:55 pm

Fort Collins, Colorado The Cancer Stem Cells Market research report offers insightful information on the Cancer Stem Cells market for the base year 2019 and is forecast between 2020 and 2027. Market value, market share, market size, and sales have been estimated based on product types, application prospects, and regional industry segmentation. Important industry segments were analyzed for the global and regional markets.

The effects of the COVID-19 pandemic have been observed across all sectors of all industries. The economic landscape has changed dynamically due to the crisis, and a change in requirements and trends has also been observed. The report studies the impact of COVID-19 on the market and analyzes key changes in trends and growth patterns. It also includes an estimate of the current and future impact of COVID-19 on overall industry growth.

Cancer stem cells market garnered a revenue of USD 798.6 million in the year 2019 globally and has been foreseen to yield USD 2,045.4 million by the year 2027 at a compound annual growth (CAGR) of 8.8% over the forecast period.

Get a sample of the report @ https://reportsglobe.com/download-sample/?rid=80767

The report has a complete analysis of the Cancer Stem Cells Market on a global as well as regional level. The forecast has been presented in terms of value and price for the 8 year period from 2020 to 2027. The report provides an in-depth study of market drivers and restraints on a global level, and provides an impact analysis of these market drivers and restraints on the relationship of supply and demand for the Cancer Stem Cells Market throughout the forecast period.

The report provides an in-depth analysis of the major market players along with their business overview, expansion plans, and strategies. The main actors examined in the report are:

The Cancer Stem Cells Market Report offers a deeper understanding and a comprehensive overview of the Cancer Stem Cells division. Porters Five Forces Analysis and SWOT Analysis have been addressed in the report to provide insightful data on the competitive landscape. The study also covers the market analysis and provides an in-depth analysis of the application segment based on the market size, growth rate and trends.

Request a discount on the report @ https://reportsglobe.com/ask-for-discount/?rid=80767

The research report is an investigative study that provides a conclusive overview of the Cancer Stem Cells business division through in-depth market segmentation into key applications, types, and regions. These segments are analyzed based on current, emerging and future trends. Regional segmentation provides current and demand estimates for the Cancer Stem Cells industry in key regions in North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa.

Cancer Stem Cells Market Segmentation:

Cancer Stem Cells Market, By Cancer Forms (2016-2027)

Cancer Stem Cells Market, By Mode Of Action (2016-2027)

Request customization of the report @https://reportsglobe.com/need-customization/?rid=80767

Overview of the table of contents of the report:

To learn more about the report, visit @ https://reportsglobe.com/product/cancer-stem-cells-market/

Thank you for reading our report. To learn more about report details or for customization information, please contact us. Our team will ensure that the report is customized according to your requirements.

How Reports Globe is different than other Market Research Providers

The inception of Reports Globe has been backed by providing clients with a holistic view of market conditions and future possibilities/opportunities to reap maximum profits out of their businesses and assist in decision making. Our team of in-house analysts and consultants works tirelessly to understand your needs and suggest the best possible solutions to fulfill your research requirements.

Our team at Reports Globe follows a rigorous process of data validation, which allows us to publish reports from publishers with minimum or no deviations. Reports Globe collects, segregates, and publishes more than 500 reports annually that cater to products and services across numerous domains.

Contact us:

Mr. Mark Willams

Account Manager

US: +1-970-672-0390

Email:[emailprotected]

Web:reportsglobe.com

See the rest here:
Cancer Stem Cells Market is Thriving Worldwide 2020-2027 | Top Companies Merck KGaA, ONCOMED PHARMACEUTICALS INC, Bionomics, MacroGenics, Inc.,...

Posted in Colorado Stem Cells | Comments Off on Cancer Stem Cells Market is Thriving Worldwide 2020-2027 | Top Companies Merck KGaA, ONCOMED PHARMACEUTICALS INC, Bionomics, MacroGenics, Inc.,…

27 De-Stressing Vegan Products to Help You Get Through The Rest of 2020 – VegNews

Posted: September 9, 2020 at 3:55 pm

Well, weve made it more than halfway through the yearcan you believe it? Schools are once again starting up (online and in-person), the weather is crisper (and drier), election season is in full throttle (register to vote!), and the global pandemic continues to ravage (please wear a mask!). As we begin to settle into September, its more important than ever to take care of our bodies and minds so we can show up at full capacity for ourselves in the present. Take a moment and check-in with yourself today, whether its with a calming, immune-boosting coffee mix-in or a CBD-infused bath soak. Wake me up when September (and 2020) ends!

1. African Botanics Revitalizing Therapy GelHunched over your laptop all day? Aside from investing in a laptop stand, utilize this invigorating gel from South African-made, eco-luxury skincare brand African Botanics to soothe neck and shoulder aches. This miracle-in-a-chic-tube promises to reduce swelling, promote circulation, and provide a cooling, thermal feeling so you can restore muscles for the next workday.

2. Clevr Golden SuperLatteCancel the caffeine jitters and opt for a turmeric-and-oat-milk latte. Naturally sweetened with monk fruit and chock-full of warming spices, this Clevr spin on trendy golden milk lattes hits the spot for a comforting, post-lunch pick-me-up.

3. OUAI Chill PillsIts Friday night and youre not going anywhere, so whats there to do? Light some candles, play some jazz, draw a hot bath, and drop in these adorable OUAI Chill Pills for some seriously luxurious me-time. Each jasmine-and-rose-scented vegan tablet is filled with hemp, jojoba, and safflower seed oil to leave skin ultra moisturized.

4. Apothkary Chill The F* Out Herbal SupplementAs fall seeps in and we get closer to peppermint mocha season, this stress-reducing, serotonin-boosting elixir from Apothkary tastes like a peppermint hot chocolate mix. While we reminisce of the snowy holidays ahead, two powerhouse adaptogensreishi and ashwagandhawork wonders to relieve our pent-up anxiety.

5. Shanti Rejuvenate Roll On With Hemp CBDAyurvedic essential oils and Colorado-sourced hemp blend seamlessly to bring clarity to stressed-out brains in this Shanti Wellness roll-on. The small, easy-to-use packaging provides relief for those on-the-go so you can be chill whatever the occasion (long lines for the grocery store, strangers refusing to wear a mask, disposable gloves all over the ground the usual).

6. Activist Skincare Healing Water Toning MistThe vegan skincare connoisseurs at Activist believe self-care is fuel for the activism we should all be doing every day. So while youre making calls, advocating for marginalized communities, and attending protests (safely and with a mask), remember to take a moment for yourself. Add this hydrating, hyaluronic mist to your desk essentials for a small, calming break. The matte glass, recyclable bottle adds an elegant design to your workstation and the refreshing scent of cucumbers instantly calms.

7. Tata Harper Aromatic Irritability TreatmentIs your work-from-home buddy chewing their cereal as loudly as possible before youve had your cup of coffee? Instead of blasting your headphones, try this essential oil blend from natural beauty queen Tata Harper. Dab a few drops onto palms, rub together, and inhale deeply for an instant mood-lifting hit of balancing jasmine, fresh geranium, and soothing cypress.

8. Facialworks Sonic Wave + Coast Is Clear DuoMissing your monthly facials? Orange County-based, non-toxic spa specialists Facialworks brings the expertise straight to your home. With its extraction duo, you can prepare skin for a painless mini-facial and use the ultrasonic skin spatula to cleanse, get rid of blackheads or pimples, and infuse serums for maximum absorption. Clear skin, here we come!

9. The Good Patch Be Calm PatchPatches are the new It item for wellness brandsfrom pimple zappers to calming mood boosters like this menthol-infused stick-on from The Good Patch. Simply peel and stick on your wrist (or other veiny part of your skin) for over eight hours and feel nerves calm by the mix of hemp and other natural ingredients.

10.ORPHEUS Resurrection All-In-One SerumInspired by the regenerative powers of the haberlea rhodopensis flower found in the mountains of Bulgaria, family-run business ORPHEUS spent more than 20 years researching the properties of the rare blossom. Now, theyve packed the unique plants stem cells into this all-in-one serum to craft a richly intensive, calming experience for stressed-out skin. Thats pretty much all you could ask for in a bottle.

11. Missionary Chocolates CBD TrufflesA chocolate a day keeps the doctor away or something like that. Naturopathic physician Melissa Berrys Portland-based Missionary Chocolates crafts the meltiest hemp-derived fair-trade chocolates for the ultimate mid-day pick-me-up. Plus, with its cute packaging, you can send your loved ones a treat to get through the hard days.

12. The Nue Co Magnesium SprayStaring at the ceiling for hours when bedtime rolls around? Its cooljust spray this sleep aid spray from The Nue Co. made with high-quality magnesiuma mineral that is essential for over 325 biochemical reactions in the bodyand youll soon stop counting sheep. You can also use it as a post-workout aid for faster muscle recovery.

13. Life & Apples Wellness Journal Planners are a useful tool to track your busy schedule, but they can also be beneficial for checking in with yourself. Made of eco-friendly, vegan materials, this 90-day rose gold journal makes it simple to track habits, plan healthy meals, and set weekly goals. Plus, you can write down what youre grateful for to begin day on a bright note.

14. Four Sigmatic Lions Mane ElixirCaffeine levels through the roof? Same here. Thats why Im turning to lions mane, a favorite mushroom among researchers and herbalists touting benefits such as boosting mood, supporting cognitive function, and providing physical energy. Add to smoothies, decaf coffee, and tea to get a boost of brain-healthy nootropics.

15. Derma-E Vitamin C Bright Eyes Hydro Gel PatchesNon-stop screen-time is sure to wreak havoc on your eye health. When suffering from tired, baggy eyes, turn to Derma-Es moisture-intensive gel patches before your morning Zoom call. These sparkly yellow gels contain allantoin to increase smoothness, caffeine to reduce puffiness, and vitamins C and B3 to target fine lines, wrinkles, and dullness.

16. Rosebud Awaken CBD Bath SoakIf youre one of the rare types that like to take baths in the mornings, this uplifting, magnesium-rich soak is for you. With notes of bergamot and orange essential oils, 50mg of CBD, and calming Epsom salts, heck, Im considering waking up an hour earlier (wish me luck) to run a warm bath and start the day on a much chiller note.

17. REN Clean Skincare Atlantic Kelp and Magnesium Salt Anti-Fatigue Exfoliating Body ScrubExfoliate your hard-working body with a fresh body scrub from sustainability-focused REN Clean Skincare designed to gently polish and smooth skin with fresh sea and Epsom salts. Breathe in sage, cypress, geranium, and rosemary for an uplifting start to the day.

18. No B.S. Charcoal Detox Peel-Off MaskTheres just something so satisfying about a peel-off mask, but when it takes forever to take off while also causing wincing pain, wed rather avoid it altogether. Enter: cruelty-free and vegan skincare brand No B.S.s purifying, activated charcoal mask. In less than 20 minutes, watch the clean, pH-balanced formulation gently peel away the days impurities and reveal smooth, bright skin.

19. Buddha Teas Peppermint CBD TeaRather than using hemp oil like many other CBD teas, Buddha Teas figured out a way to use dispersible water-soluble CBD, ensuring optimal bioavailability and maximum absorption of the calming, non-psychoactive compound. With flavors such as Turmeric & Ginger, Matcha Green, and Peppermint, grab your tea setsits time for relaxation!

20. Pacifica Overnight Vegan Collagen Recovery CreamYour skin repairs itself at night, making the products used for your nighttime ritual all the more important. For those needing a little more glow, this Pacifica recovery cream infuses vegan collagen, essential lipids, antioxidants, and flower extracts to work some magic during your beauty sleep. Glowing, radiant skin, were dreaming of you!

21. Future Kind Vegan Sleep SupplementsStress hits hard at night when youre trying to get your Zzzs, which is why brothers and nutritionists Shaun & Eliot Cunningham developed Future Kinds eight-ingredient, all-natural sleep supplement that promises to have you feeling energized the next morningnot sluggishthanks to the addition of L-theanine.

22. Peak + Valley Balance My Stress BlendThrough the use of adaptogens such as reishi mushroom, eleuthero root, and ashwagandha, Black-owned wellness brand Peak + Valleys chocolaty, earthy stress blend pairs well with an afternoon tea or a warm cup of oat milk to protect the immune system and decrease fatigue.

23. HERBIVORE CALM Soaking SaltsEveryones favorite Himalayan pink salt blends with ylang-ylang and vanilla to soothe the body with this bath soak from plant-based, sustainable skincare brand HERBIVORE. Dont forget to recycle the chic glass bottle to reduce waste.

24. Heartsong Herbs Anxiety Away SupplementUsing regenerative growing practices to preserve soil and create stronger, more potent plants, small farm Heartsong Herbs takes its agriculture seriously. Crafting high-quality tinctures, the apothecarys Anxiety Away pairs herbs such as skullcap, passionflower, blue vervain, and lemon balm to ease away worries and help you feel grounded.

25. Kin Euphorics High RhodeNot in the mood for another lengthy Zoom happy hour and the inevitable hangover in the A.M.? Dont fret, you can still catch up with friends without the pressure. Grab a can of non-alcoholic High Rhodean herbaceous drink promising a state of bliss through a holistic mix of adaptogens, nootropics, and botanics. Kiss the morning-after headaches goodbye!

26. Naipo Massage GunWe cant go to a spa for an hour-long deep-tissue massage, so why not bring it home? This Naipo massager puts in the work and all you have to do is hold it over tense muscles to alleviate stiffness and relieve any pain. The portable design plus long battery life means you can keep it near you at all times for when the soreness starts to set in.

27. Asop Istros Aromatique Room Spray Weve all had to keep our imaginations alive during the months-long quarantine, so spend a few minutes daydreaming a walk through a lively, smoky Greek bazaar to get the creative juices flowing during a mid-day slump. Cult-favorite plant-based skincare brand Asops room spray should help with notes of pink pepper, lavender, tobacco.

Aruka Sanchir (@arukasanchir)is the Beauty & Style Editor at VegNews and shes always trying out new calming products to find her ultimate Zen.

Please support independent vegan media and get the very best in news, recipes, travel, beauty, products, and more.Subscribe now to the worlds #1 plant-based magazine!

See original here:
27 De-Stressing Vegan Products to Help You Get Through The Rest of 2020 - VegNews

Posted in Colorado Stem Cells | Comments Off on 27 De-Stressing Vegan Products to Help You Get Through The Rest of 2020 – VegNews

THE BONDS OF FRIENDSHIP: OXFORD AND SUNWAY – The Star Online

Posted: September 9, 2020 at 3:55 pm

I AM Jeffrey Cheah Professorial Fellow and Tutor in Medicine at Brasenose College, Oxford, and Professor of Virology at the Sir William Dunn School of Pathology, University of Oxford.

It has been my privilege, as a Jeffrey Cheah Fellow, to pay several academic visits to Sunway over the last few years to contribute to academic conferences, and to meet staff and students of the university.

By visiting Sunway one can immediately see what a visionary like Sunway Group founder and chairman Tan Sri Dr Jeffrey Cheah can achieve in a few decades.

Built on the site of a disused tin mine, a city has risen with shopping malls, shopping strips, hotels, residences, a theme park, a major hospital and an educational precinct, which has Sunway University as its centrepiece.

Although universities differ vastly in age, students remain always young. And, like their contemporaries in Oxford, they are smart, inquisitive and uncynical, so it is always a pleasure to visit.

I feel that there is an enormous pool of young talent in Malaysia that needs the opportunity for learning that outward-facing universities like Sunway can offer.

Tan Sri Dr Cheah's vision to engage with the most illustrious universities in the world, and his success in doing so is truly remarkable. My appointment as Jeffrey Cheah Professorial Fellow allows for all kinds of joint work between our two institutions.

In Brasenose College, through the Jeffrey Cheah Scholar-in-Residence programme, we have a stream of Sunway academics residing in Oxford each year, making connections and fostering the development of joint projects.

As a young university, Sunway will benefit greatly from the bonds of friendship with the oldest university in the UK and, dare I say, the top university in the world.

We are always willing to associate ourselves with Sunway in carrying out collaborative projects in areas of mutual expertise, which can bring renown to our respective institutions and to Malaysia.

Although best known for our work on the biology of HIV infection of macrophages, my lab has had a continuing interest in the biology of more exotic enveloped RNA viruses including dengue, Zika, and Bunyamwera viruses that from time to time cause serious outbreaks around the world, and which in principle could re-emerge as public health problems more widely.

At the beginning of 2020, we were very focused on using the stem cell-based technology we had developed for HIV research to investigate the genetic control of chronic inflammatory processes in both HIV-associated neurocognitive disease and in common neurodegenerative disorders.

As the pandemic began to take hold, however, we realised that our steam age virology expertise was in short supply in the UK and could make a significant contribution to the urgent search for effective new therapies and vaccines for Covid-19.

Accordingly, during March my colleagues and I began the process of reconfiguring the containment level III laboratory suite at the Sir William Dunn School of Pathology, which we had built for HIV research 25 years earlier, to handle the new coronavirus.

This rapid turnaround gained certification by the HSE over Easter, and we set about establishing standardised procedures for evaluating both new candidate drugs to treat Covid-19 infection, and antibodies to provide immunity to infection.

This was in no small measure made possible by generous contributions to the universitys rapid response fund by philanthropic donors. We have been able to recruit and train about a dozen scientists, whose research projects on other viruses had been temporarily suspended during the lockdown, to constitute dedicated teams to run each of these specialised procedures.

I have taken personal responsibility for the team evaluating the neutralising potency of antibodies and related molecules, and it has been very rewarding to be able to evaluate cutting-edge candidate molecules coming, not only from academic and clinical laboratories in Oxford and the Oxford region, but also from biotech companies as far apart as Colorado and Guangzhou.

In a very short time, we have been able to identify extremely promising candidates, the results of which are now already in the public domain, and which are being actively pursued for clinical development.

We have recently developed a new, high throughput technique, which will enable us to evaluate many more samples and recently began an exciting new phase in which we use the technique to investigate the quality of antibody responses made by participants in the first phase of the Oxford Covid-19 vaccine programme.

As lockdown eases, the scientists who have been seconded to the core virus facility are beginning to think once again about returning to their main research projects.

Accordingly, we are actively investigating ways in which we can put the core virology service on a more sustainable footing.

We are very conscious that the world remains vulnerable not only to second waves of SARS-CoV-2 but also to other as yet unidentified emerging viruses, and are determined to play our part in ensuring that future generations have the ability to respond rapidly and effectively.

About Prof William James

A Jeffrey Cheah Professororial Fellow Emeritus and Fellow in Medicine at Brasenose College, Oxford, Prof James is a virologist with a background in genetics and microbiology.

As the Professor of Virology with University of Oxford, he is the principal investigator at the Stem Cell Research Institute of Oxford, running a research lab studying HIV-macrophage biology using stem cell technology.

His research interest since the mid-1980s has been largely focused on the AIDS virus, HIV-1, particularly how it replicates in macrophages and how smart nucleic acids can be developed to prevent its replication.

He focuses on how stem cells can be used to rewrite the defence cells of the brain to make them resistant to HIV. It could one day provide insights into which drugs can be used to help slow down or prevent the neuro-degenerative effects of the virus.

He was also the University of Oxfords Pro Vice-Chancellor for Planning and Resource Allocation from 2011 to 2017.

More:
THE BONDS OF FRIENDSHIP: OXFORD AND SUNWAY - The Star Online

Posted in Colorado Stem Cells | Comments Off on THE BONDS OF FRIENDSHIP: OXFORD AND SUNWAY – The Star Online

Page 903«..1020..902903904905..910920..»