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Dr. Haqqani: Eliminating disparity in health care – Midland Daily News

Posted: July 9, 2020 at 3:54 pm

Omar P. Haqqani, for the Daily News

Dr. Haqqani: Eliminating disparity in health care

The medical community should make every effort to eliminate the impact of racism in health care. Although the disparities are being brought to light by the current pandemic, the problem has been acknowledged in the past. Now is the time for health care professionals to aggressively seek to reverse the impact of negative attitudes and practices that have long been in place.

Causes and effects of racism in health care

There is an alarmingly high national rate of COVID-19 hospitalizations and deaths within the minority community, according to The Centers for Disease Control and Prevention. It is 4.5% higher for African Americans than that of the non-minority population. It also rises for Hispanic or Latino individuals and Native Americans.

Aside from the increases brought to light by the coronavirus, the disparity in general good health can be seen across the board in every medical arena. The higher rates of diabetes, obesity, hypertension and other conditions among minorities have contributed not only to higher coronavirus consequences, but to cardiovascular issues, kidney failure and other dangerous circumstances.

In a report published in the archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine in 2019, unequal access to medical care for minorities is a major factor in fostering health inequities. Other factors in maintaining or widening the gap include a lack of childhood development, a higher rate of poverty, and income inequality between minority workers and non-minority workers. Housing and other social and economic factors are also important in the health care disparity discussion. While they may not all seem related specifically to medical care, they result in inadequate circumstances for minorities.

Lack of preventative care

The economic disadvantages more frequently faced by minorities in childhood and adulthood lead to less consistent medical care. Infrequent checkups and less education about signs of disease increase the odds of major health difficulties. According to the NIH/NLM report, only 3% of all health care money in the United States is spent on preventative care. Many dangerous medical conditions, including cardiovascular issues, are preventable, or at least more controllable when warning signs are detected.

The economic factors of racism decrease the probability of prevention. Because wages are lower, doctor visits are infrequent. Many low paying jobs do not include health benefits. Workers may also resist relinquishing a day's pay to go to a doctor's office for a checkup, as well.

Availability and procedural disparities

The there is also a fracture quality of health care for minorities once a diagnosis is made and treatment is prescribed. The impact of this is obvious in all age groups. Infant mortality rates are higher and life expectancy is shorter in minority communities. In one example of specific treatment recommendations, the Journal of the American Society of Nephrology cites a study that revealed that 35% fewer minority patients who were eligible for kidney transplants received them, versus the non-minority eligible patients.

Steps the medical community must take

Addressing social risk factors among minorities, diversifying the health care work force, improving the availability of health care and providing more avenues to primary care are among the strategies that can help.

There are programs in place that provide outreach into minority and underprivileged communities to provide better health care. Medical institutions should encourage their doctors and nurses to participate in programs that deal with childhood intervention, senior care and assistance to the disabled.

The American Medical Association has acknowledged that bias exists within health systems and peripheral institutions that contribute to the disparities. Health professionals and institutions are being urged to examine and correct it.

Ask Dr. Haqqani

If you have questions about your cardiovascular health, including heart, blood pressure, stroke lifestyle and other issues, we want to answer them. Please submit your questions to Dr. Haqqani by e-mail at questions@vascularhealthclinics.org.

Dr. Omar P. Haqqani is the chief of Vascular and Endovascular Surgery at Vascular Health Clinics in Midland: http://www.vascularhealthclinics.org

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Cannabis and Coronavirus – Tucson Weekly

Posted: July 9, 2020 at 3:54 pm

You might not be able to run to the local MMJ outlet to buy a cure-all for COVID-19, but cannabis is still on the menu, with at least two clinical studies underway evaluating CBDs for prevention and treatment of the novel coronavirus.

Even if it is not the panacea the world is looking for, use of MMJ is probably a lot safer than injecting disinfectant into your veins.

While studies for coronavirus therapies are in the infancy stages, some have shown promise blocking the virus, and as an anti-inflammatory agent for those afflicted with the disease. Two such studies, originating in Canada and Israel, have recently caught the attention of medicinal cannabis advocates hoping to further legitimize the herb as mainstream medicine.

The studies are not for an anti-virus vaccine, but as therapies that could enhance primary treatment and "prevention strategies" to deny the virus entry into the body or as an anti-inflammatory treatment that may help prevent acute respiratory distress for those afflicted with the disease.

The Canadian study is a collaboration between the University of Lethbridge, Pathway Rx, a Canadian pharmaceutical research company that develops cannabis therapies and Swysh, Inc., a cannabinoid-based oral health company.

In April, the group released a preclinical study for peer review titled, "In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues."

The study looked at hundreds of strains of cannabis and their effect on artificial lung, oral/nasal and intestinal tissue and their ability to modulate angiotensin-converting enzyme 2 (ACE2). According to researchers involved in the study, ACE2 is a receptor required for COVID to enter the cells.

"ACE2 may be the way COVID enters the cell," Heather Moroso, NMD said. "If you make more of it, it's basically like opening more doors for the virus to enter. If you make less or block ACE2, then potentially that's fewer doors for the virus to enter."

If the research proves successful, the resulting medications could be administered in the form of mouthwash, gargle, inhalants or gel caps, according to those involved with the study. Smoking cannabis, on the other hand, might exacerbate lung problems brought on by the virus.

"There is some evidence that smoking in general may make one more vulnerable to COVID," Moroso said.

Researchers say a fraction of the strains that have been tested have shown success in reducing virus receptors by as much as 73 percent.

Studies may have hit roadblocks though, as a lack of clinical trials and insufficient funding has kept the work in its infancy phase.

The Israeli study, a collaboration between InnoCan Pharma of Israel and Tel Aviv University, focuses on products using CBD-loaded exosomes to treat lung inflammation.

The exosomes could be safely administered without adverse reactions, creating a potentially safe delivery system via inhalation for a variety of lung infections in COVID patients. The study focused on CBDs in order to reduce patient impairment that may be caused by higher levels of THC in other forms of the drug.

While the studies represent something of a boon for cannabis advocates, locally, response to the reports is that it's "not ready for prime time."

To begin with, the Canadian study utilized artificial tissue models, so it is not clear if the results would be the same if conducted on living humans.

"The [Lethbridge] paper utilizes tissue models which are very far removed from human, or animal, organs in-situ and hence any conclusions must be taken with great caution," said a retired Tucson neuroscientist who declined to be identified for this report. "In my opinion, the results are extremely preliminary and may not have any relevance to the question at hand: adjunct therapies to combat COVID-19 infection."

There is also a problem of "confirmation bias," which means there may be a subconscious desire for a cannabis "miracle cure" that may lead to a loss of objectivity in processing the results of studies on the drug.

"Everybody wants cannabis to be a cure-all miracle drug," Moroso said, adding that while the state of Arizona does not recognize sleep issues as qualifying conditions, sleep can be an important aspect to stress reduction.

Additionally, during the current state of the pandemic, MMJ can have positive effects on patients experiencing anxiety over their lives and futures, as the economic and health impacts of a global pandemic make the future murky, at best.

"Cannabis can help people suffering from anxiety, depression and post-traumatic stress disorder," Moroso said. "The stress and anxiety of being in isolation; unknown job and family situations; domestic abuse and isolation? I'm not a rocket scientist, but sensible use of the drug can help reduce the anxiety."

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Purdue will require all students to be tested for COVID-19 before start of the fall semester – Purdue News Service

Posted: July 9, 2020 at 3:54 pm

WEST LAFAYETTE, Ind - As the next step to protect the health and safety of everyone on campus and the community, Purdue University announced today (July 8) that it is formulating plans to require and pay for all West Lafayette-bound students to be tested for COVID-19 before moving into residence halls and attending classes this August.

The program will be led by Dr. Esteban Ramirez, chief medical officer at the Protect Purdue Health Center (PPHC), and was developed in consultation with the Protect Purdue Medical Advisory Team. Dr. Ramirez is an experienced internist and clinical assistant professor at the Indiana University School of Medicine-West Lafayette. Under Dr. Ramirez direction, the PPHC is the Universitys virtual health center launched last week to coordinate the overall workflow of COVID-related case management on campus.

Through its Protect Purdue initiative, undergraduate, graduate and professional program students will soon be provided instructions and assistance on how and when to get tested for COVID-19, beginning in early August before traveling to campus.

Student test results will be sent to the Protect Purdue Health Center, and those testing positive should not travel to West Lafayette or come to campus for any reason until they isolate for 14 days and are medically-cleared to return by the PPHC.

Failure to complete a COVID-19 test and have those results filed with the Protect Purdue Health Center prior to arrival will affect a students ability to move into a residence hall or begin in-person classes when they resume on Aug. 24. Academic support will be available through virtual consultations with staff specializing in student success to help undergraduate students navigate their continued academic progress if they must isolate because of COVID-19.

For students already on campus or arriving for various early-start programs throughout July, the University and the Protect Purdue Health Center are developing plans to rapidly sample and test individuals through a combination of resources provided by on-campus, local and outside partners.

The University will cover costs of all student testing. Purdue is expecting a potentially record number of freshmen this fall, with a student body of more than 40,000 total.

Our comprehensive Protect Purdue Plan affords us the unique flexibility and adaptability to respond to rising COVID-19 cases across parts of the country and help protect our Purdue community in real time, Ramirez said.

We are committed to facilitating the testing of our students who span the nation and the globe before they return to the residence halls, classrooms and West Lafayette community this August by way of our Protect Purdue Health Center, Ramirez added. "Through these preventative and proactive measures, we take another important step to protect the student body, our faculty, staff, overall campus and members of the local community particularly the most vulnerable amid concerning national trends.

Undergraduate, graduate and professional program students: All students living on campus this fall will be required to be tested for COVID-19 and have a negative test result on file with the Protect Purdue Health Center prior to moving into their residence hall in August.

Those students living off campus also will be required to be tested for COVID-19 and have negative test results on file with the PPHC prior to participating in an on-campus program in August or attending their first in-person class.

Specific instructions will soon be provided on how and when to get tested for COVID-19 in August before traveling to campus, while allowing adequate time for processing and reporting test results before arrival.

For students participating in Early Start, Summer Start and other programs throughout July, as well as students already at Purdue for work, research or classes this summer, special arrangements have been made to test them on campus or in collaboration with local testing partners.

Faculty and staff: Faculty and staff are not required to be COVID-19 tested at this time provided they are not sick, experiencing any symptoms of COVID-19, and have not been exposed to someone who has tested positive for COVID-19.

All faculty and staff, particularly those working on campus this summer and fall, are encouraged to adhere to the components of the Protect Purdue Pledge, particularly monitoring and reporting any signs or symptoms of COVID-19 to the Protect Purdue Health Center by calling 765-496-INFO (4636) or toll-free at 833-571-1043. The caller will be connected to a registered nurse case manager, who will help determine the appropriate course of care, which could include self-quarantine and a COVID-19 test.

Integrated Monitoring and Surveillance Plan: The Protect Purdue Health Center, the single-point health center for all things COVID-19-related for the Purdue community, is staffed with a dedicated team of physicians, registered nurses, case managers, contact tracers and support staff. Ramirez said the PPHC is working closely with the Protect Purdue Health Monitoring and Surveillance Team as well as the Medical Advisory Team to ensure the safety, health and well-being of individuals and the community.

As the semester progresses, the Protect Purdue Health Center will provide ongoing case management, which will include monitoring and testing of both symptomatic individuals and close contacts who might have been exposed to positive individuals. The protocols for testing and contact tracing have been developed in accordance with the guidelines set by the Centers for Disease Control and Prevention and the Indiana State Department of Health.

When the comprehensive Protect Purdue Plan was announced on June 12 for reopening the campus this fall, the University began the capabilities to rapidly assess, sample and test any student, faculty or staff member reporting COVID-19 symptoms and those identified through clinically relevant contact tracing.

About Purdue University:

Purdue University is a top public research institution developing practical solutions to todays toughest challenges. Ranked the No. 6 Most Innovative University in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery. Committed to hands-on and online, real-world learning, Purdue offers a transformative education to all. Committed to affordability and accessibility, Purdue has frozen tuition and most fees at 2012-13 levels, enabling more students than ever to graduate debt-free. See how Purdue never stops in the persistent pursuit of the next giant leap atpurdue.edu.

Media contact: Tim Doty,doty2@purdue.edu

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WHO sees first results from coronavirus drug trials within two weeks – The Indian Express

Posted: July 9, 2020 at 3:54 pm

By: Reuters | Geneva, London | Published: July 4, 2020 6:39:32 am There is no proven vaccine against the disease now, while 18 potential candidates are being tested on humans.

The World Health Organization (WHO) should soon get results from clinical trials it is conducting of drugs that might be effective in treating COVID-19 patients, its Director General Tedros Adhanom Ghebreyesus said on Friday.

Nearly 5,500 patients in 39 countries have so far been recruited into the Solidarity trial, he told a news briefing, referring to clinical studies the U.N. agency is conducting.We expect interim results within the next two weeks.

The Solidarity Trial started out in five parts looking at possible treatment approaches to COVID-19: standard care; remdesivir; the anti-malaria drug touted by U.S. President Donald Trump, hydroxychloroquine; the HIV drugs lopinavir/ritonavir; and lopanivir/ritonavir combined with interferon.

Earlier this month, it stopped the arm testing hydroxychloroquine, after studies indicated it showed no benefit in those who have the disease, but more work is still needed to see whether it may be effective as a preventative medicine.

Mike Ryan, head of the WHOs emergencies programme, said it would be unwise to predict when a vaccine could be ready against COVID-19, the respiratory disease caused by the novel coronavirus that has killed more than half a million people.

While a vaccine candidate might show its effectiveness by years end, the question was how soon it could be mass produced, he told the U.N. journalists association ACANU in Geneva.

There is no proven vaccine against the disease now, while 18 potential candidates are being tested on humans.

WHO officials defended their response to the virus that emerged in China last year, saying they had been driven by the science as it developed. Ryan said what he regretted was that global supply chains had broken, depriving medical staff of protective equipment.

I regret that there wasnt fair, accessible access to COVID tools. I regret that some countries had more than others, and I regret that front-line workers died because of (that), he said.

He urged countries to get on with identifying new clusters of cases, tracking down infected people and isolating them to help break the transmission chain.

People who sit around coffee tables and speculate and talk (about transmission) dont achieve anything. People who go after the virus achieve things, he said.

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WHO says it was first alerted to coronavirus by its office, not China – The Japan Times

Posted: July 9, 2020 at 3:54 pm

Geneva/London The World Health Organization has updated its account of the early stages of the COVID-19 crisis to say it was alerted by its own office in China, and not by China itself, to the first pneumonia cases in Wuhan.

The U.N. health body has been accused by U.S. President Donald Trump of failing to provide the information needed to stem the pandemic and of being complacent towards Beijing, charges it denies.

On April 9, WHO published an initial timeline of its communications, partly in response to criticism of its early response to the outbreak that has now claimed more than 521,000 lives worldwide.

In that chronology, WHO had said only that the Wuhan municipal health commission in the province of Hubei had on Dec. 31 reported cases of pneumonia. The U.N. health agency did not, however, specify who had notified it.

WHO chief Tedros Adhanom Ghebreyesus told a news conference on April 20 that the first report had come from China, without specifying whether the report had been sent by Chinese authorities or another source.

But a new chronology, published this week by the Geneva-based institution, offers a more detailed version of events.

It indicates that it was the WHO office in China that on Dec. 31 notified its regional point of contact of a case of viral pneumonia after having found a declaration for the media on a Wuhan health commission website on the issue.

The same day, WHOs epidemic information service picked up another news report transmitted by the international epidemiological surveillance network ProMed based in the United States about the same group of cases of pneumonia from unknown causes in Wuhan.

After which, WHO asked the Chinese authorities on two occasions, on Jan. 1 and Jan. 2, for information about these cases, which they provided on Jan. 3.

WHO emergencies director Michael Ryan told a news conference Friday that countries have 24-48 hours to officially verify an event and provide the agency with additional information about the nature or cause of an event.

Ryan added that the Chinese authorities immediately contacted the WHO as soon as the agency asked to verify the report.

WHO chief Tedros Adhanom Ghebreyesus told a news briefing that the organization should soon get results from clinical trials it is conducting of drugs that might be effective in treating COVID-19 patients. | AFP-JIJI

Trump has announced that his country, the main financial contributor to WHO, will cut its bridges with the institution, which he accuses of being too close to China and of having poorly managed the pandemic.

The WHO denies any complacency toward China.

Also Friday, Tedros told a news briefing that the WHO should soon get results from clinical trials it is conducting of drugs that might be effective in treating COVID-19 patients.

Nearly 5,500 patients in 39 countries have so far been recruited into the Solidarity trial, he said, referring to clinical studies the U.N. agency is conducting.

We expect interim results within the next two weeks.

The Solidarity Trial started out in five parts looking at possible treatment approaches to COVID-19: standard care; remdesivir; the anti-malaria drug touted by Trump, hydroxychloroquine; the HIV drugs lopinavir/ritonavir; and lopanivir/ritonavir combined with interferon.

Earlier this month, it stopped the arm testing hydroxychloroquine, after studies indicated it showed no benefit in those who have the disease, but more work is still needed to see whether it may be effective as a preventative medicine.

Ryan, the WHOs emergencies program chief, said it would be unwise to predict when a vaccine could be ready against COVID-19, the respiratory disease caused by the novel coronavirus that has killed more than half a million people.

While a vaccine candidate might show its effectiveness by years end, the question was how soon it could be mass produced, he told the U.N. journalists association ACANU in Geneva.

There is no proven vaccine against the disease now, while 18 potential candidates are being tested on humans.

WHO officials defended their response to the virus that emerged in China last year, saying they had been driven by the science as it developed. Ryan said what he regretted was that global supply chains had broken, depriving medical staff of protective equipment.

WHO emergencies director Michael Ryan | Pool via REUTERS

I regret that there wasnt fair, accessible access to COVID tools. I regret that some countries had more than others, and I regret that front-line workers died because of (that), he said.

He urged countries to get on with identifying new clusters of cases, tracking down infected people and isolating them to help break the transmission chain.

People who sit around coffee tables and speculate and talk (about transmission) dont achieve anything. People who go after the virus achieve things, he said.

On the sidelines ACANU briefing, another top WHO official said almost 30 percent of genome sequencing data from samples of the COVID-19 virus collected by the body have shown signs of mutation, but there is no evidence this has led to more severe disease.

I think its quite widespread, said Soumya Swaminathan, WHO chief scientist.

The U.N. agency has so far collected 60,000 samples of the disease, she said.

Scientists at Scripps Research this month found that by April the mutated virus accounted for some 65 percent of cases submitted from around the world to a major database.

The genetic mutation in the new coronavirus, designated D614G, significantly increases its ability to infect cells and may explain why outbreaks in northern Italy and New York were larger than ones seen earlier in the pandemic, they found in a study.

Maria Van Kerkhove, technical lead on the COVID-19 pandemic at the WHO, said at Fridays briefing the mutated strain had been identified as early as February and had been circulating in Europe and the Americas.

So far, there is no evidence it leads to more severe disease, she said.

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Can I refuse a temperature check? What to know about the COVID-19 screening tool – MSN Canada

Posted: July 9, 2020 at 3:54 pm

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As Canada continues to reopen, some grocery stores, salons and other businesses have implemented temperature screening an approach that uses a touchless scanner to measure a persons body temperature in an attempt to prevent the spread of the novel coronavirus.

The process was made mandatory for all air travellers in Canada in mid-June. Any passenger who shows a fever on two measurements, taken 10 minutes apart, will be asked to rebook after 14 days.

However, some experts wonder whether the step is effective given a person can shed the COVID-19 virus without having a fever or any change in body temperature. The tool often used to measure temperature has also been shown to be unreliable.

READ MORE: Temperature screening not always reliable to mitigate coronavirus risk, experts say

For those reasons, temperature screening has not been recommended by Canadas chief public health officer Theresa Tam. In fact, she quickly shut down the approach when more businesses began implementing the practice in May.

The more you actually understand this virus, the more you begin to know that temperature-taking is not effective at all, Tam said in a ministerial update that month.

Tam said the likelihood of screening someone who was symptomatic was relatively inefficient in comparison to those who were asymptomatic.

If we have a significant number of asymptomatic or pre-symptomatic people, that also even reduces the effectiveness even more.

Dr. Susy Hota, the medical director of the Infection Prevention and Control and Medical Device Reprocessing department at the University Health Network in Toronto, agrees.

"There really are a lot of limitations to temperature checks, and I'm not really convinced that they're worth investing in for this purpose," Hota said.

READ MORE: Canada to screen air travellers for fever amid coronavirus pandemic: Trudeau

There are also inaccuracies with the temperature probes used for this purpose, Hota said.

She worries they can give patrons and business owners a "false sense of security."

Temperature screening is typically not an effective way to detect COVID-19 when used on its own, and that's because of the way the virus spreads.

"When we talk about the issue of pre-symptomatic shedding and transmission, we're talking about people who have no symptoms yet so no fever," Hota said.

"Once you've developed the fever, we know what we're dealing with ... but in the pre-symptomatic phase, a temperature check won't help."

Problems can also arise from the touch-less temperature probes currently being used in airports, grocery stores and by other businesses.

"It's a variable that ... isn't infallible," said Dr. Leighanne Parkes, infectious disease specialist and microbiologist at the Jewish General Hospital in Montreal.

"It depends on the instrument that we're using, the ambient temperature, (if) the instrument is calibrated correctly, is the individual coming in from a hot outside or a cold outside?"

All these things come into play when a temperature probe is used, making true measures hard to come by.

READ MORE: You might be wearing your mask, gloves wrong. How to use PPE properly

There are also other reasons a person's body temperature could be elevated that don't have to do with COVID-19.

Medication, certain pre-existing conditions, weather and what you were doing immediately prior to having your temperature checked are all factors that can affect your body temperature, Hota said.

"It is possible that your ambient temperature and what you were doing before ... might register a higher temperature than you really would have otherwise," she said.

However, Parkes believes temperature screening could be helpful when it's "bundled" with other preventative health measures.

"If you have an adequately calibrated machine, you're [testing the person's temperature] indoors using appropriate techniques and ... you're also symptom-screening for things that are not fever, and risk factors including contact, those altogether can pick up some of the most high-risk cases," Parkes said.

Temperature screening should be considered just one layer in a "pyramid of prevention," she said.

"It's not a replacement for the other means that we have in place, such as social distancing, masking in public spaces, adequate ventilation, adequate environmental cleaning ... all those things combined."

Although temperature screening may not accurately detect COVID-19, it's still within the rights of a business to deny you service on the grounds of a high temperature.

This is because employers and employees have the right to a safe working environment.

"You can't be denied entry on grounds of race or religion ... because that's discrimination, but if your temperature is above some arbitrary scale, then you can be denied entry," said Bernard Dickens, professor emeritus of health law and policy in the faculty of law, faculty of medicine and Joint Centre for Bioethics at the University of Toronto.

READ MORE:Planes, salons and grocery stores: Companies that require masks in Canada

"It's a security ground ... to protect the staff who work in the facility. They have a right to a safe working environment, and the store is responsible for the safety of its employees."

Basically, any business can make conditions for who they serve as long as they don't discriminate [and they're not] in violation of the human rights code.

For this reason, you can refuse to take a temperature test, but the store can refuse your entry upon doing so.

"You have no right to go into the store ... because the store can set reasonable conditions [for protection]," Dickens said.

Questions about COVID-19? Here are some things you need to know:

Symptoms can include fever, cough and difficulty breathing very similar to a cold or flu. Some people can develop a more severe illness. People most at risk of this include older adults and people with severe chronic medical conditions like heart, lung or kidney disease. If you develop symptoms, contact public health authorities.

To prevent the virus from spreading, experts recommend frequent handwashing and coughing into your sleeve. They also recommend minimizing contact with others, staying home as much as possible and maintaining a distance of two metres from other people if you go out.

In situations where you can't keep a safe distance from others, public health officials recommend the use of a non-medical face mask or covering to prevent spreading the respiratory droplets that can carry the virus.

For full COVID-19 coverage from Global News, click here.

With files from Global News' Emerald Bensadoun

Meghan.Collie@globalnews.ca

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In 1918, Indianapolis required masks during the fight against ‘The Great Influenza’ – WRTV Indianapolis

Posted: July 9, 2020 at 3:54 pm

INDIANAPOLIS Dr. Herman G. Morgan, the 33-year-old secretary of the Indianapolis Board of Health, presented the situation in simple terms.

In November 1918, Indianapolis and the rest of the world were in the grips of the worst influenza pandemic in history. Less than two months had passed since the city's newspapers reported the first cases among soldiers stationed at the Indiana School for the Deaf and Fort Benjamin Harrison.

Morgan's Board of Health issued sweeping orders in early October 1918, similar to those the city imposed in March and April 2020 in the fight against the COVID-19 pandemic.

Schools and churches closed. Businesses and theaters shut down. Public meetings were banned. Streets emptied.

Newspapers.com

By November, Indianapolis began reopening and its citizens gathered in celebration of victory in World War I, leading to another rise in cases, according to Bill Beck, a current member of the Marion County Historical Society's board of directors.

"Flu cases had spiked late the week before in the wake of the Armistice celebrations on Monday, Nov. 11, and the Board of Health reacted by trying to get ahead of the curve," Beck said.

Morgan determined it was time for citizens to wear masks in public or risk the city shutting down for a second time.

"The board of health has placed on the individual and, to a larger extent, his employer, the matter decided of whether business shall continue in Indianapolis," Morgan said in the Indianapolis Star on Nov. 20, two days after the mask requirement was announced. "If there is a tendency on the part of the public to disregard the health regulation, the only resort is to close up all business houses and public gathering places."

No ordinary flu

The H1N1 flu, also known as the Spanish Flu and La Grippe, was both rapid and violent.

Fueled by soldiers moving around the globe at the end of World War I, the Centers for Disease Control and Prevention estimates the flu infected one-third of the world's population and killed at least 50 million people worldwide, including 675,000 Americans.

The author John H. Barry wrote in his book "The Great Influenza" the first confirmed cases appeared on March 4, 1918, at Fort Riley, Kansas. It finally subsided in the summer of 1919 after arriving in three waves. The second wave in the fall of 1918 was the most severe.

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In his book, Barry described the swiftness with which the virus struck its victims and the horrifying symptoms many experienced.

"Symptoms were terrifying," Barry wrote. "Blood poured from the noses, ears, eye sockets; some victims lay in agony; delirium took others away while living."

The Indianapolis Star reported on Nov. 24 that 3,266 Hoosiers died statewide from the flu in October, and 3,020 children became orphans. The illness struck the youngest and strongest adults the hardest.

"More than 53 percent of the 3,266 persons who died of influenza-pneumonia in Indiana during October were between the ages of 20 and 40 years," the Star reported.

Beck said his grandfather was a mortician in Indianapolis during the pandemic.

My dad remembered never seeing his father that whole fall because he was so busy burying people," Beck said. This thing was so lethal that people would basically come down with it one morning and be dead the next morning."

'But we gotta do it'

With cases rising, on Nov. 18, the Indianapolis Board of Health announced an order requiring face masks, along with the closure of all schools.

In that evening's edition of The Indianapolis News, Morgan said masks "should be made of cheese cloth, surgeon's gauze or other porous material." The News reported the board considered re-closing the city, but first wanted to attempt the mask order.

"The board said the order requiring the wearing of masks was adopted in the hope that thereby the necessity for a renewal of the general closing order would be avoided," the News reported. "It is up to the business men and the managers of business houses, theaters, poolrooms, barber shops and all other public places to see to it that persons without masks are barred. Places which violate this ruling will be closed."

Newspapers.com

In a Nov. 20 piece headlined, "All Dressed Up Like a Horse, With a Goshawful Nosebag--but We Gotta Do It," Indianapolis Star columnist Mary E. Bostwick described the scene in offices and streets as people acclimated themselves to wearing face masks.

"On the street, the masks were seen yesterday at intervals, although not frequently enough to keep the unmasked citizens from snickering at their brethren who were going around with their faces all under cover," Bostwick wrote. "But the mask wearers did not care. No one could tell who they were anyway."

While she found some humor and ridiculousness in the situation, in the end, Bostwick concluded the mask order was necessary.

"Whether we want to or not, we positively must not go anyplace indoors with our faces undressed," she wrote. "And if we get to chortling raucously at somebody so adorned, remember we look just as funny ourselves."

Newspapers.com

Still, same as today, there were those who fought against the mask order.

While the penalty for violating Marion County's order that is scheduled to go into effect Thursday is a fine of up to $1,000, the city treated "mask slackers" harshly in 1918. On Nov. 22, The Indianapolis Star reported three men were arrested in a hotel lobby after they refused to wear masks.

"They were released at the City Prison on their own recognizance," according to the Star.

As objections to wearing masks continued, Morgan spoke about the importance of following the order. In the Star on Nov. 24, he pleaded with citizens to wear masks in order to prevent the city from being shut down for a second time.

He emphasized the wearing of masks "is not a pet whim of any member of the health department" and that "the cooperation of the majority of people is absolutely necessary to make any preventative measure a success."

In full, Morgan said:

This was not for the purpose of causing an inconvenience to the public, as some conscientious objectors have stated, but to prevent infection from being transferred from one individual to another. The wearing of gauze masks is not a pet whim of any member of the health department. This method of preventing cross infection has been successfully used in a number of cities and has been used by surgeons for years to prevent droplet infection from reaching the field of operation. The mask has been adopted by military hospitals in both the general and infectious wards. Medical literature is full of data which proves conclusively the efficiency of this method.

When a community is confronted with a serious epidemic, the cooperation of the majority of the people is absolutely necessary to make any preventative measure a success. This is not a time for destructive criticism, petty jealousies or all-time 'knockers,' but an occasion for every individual to aid in the enforcement of the preventative measure to end that disease and death may be reduced to a minimum.

A turn for the better

At the beginning of the following week, however, Morgan was pleased with the results of the city's mask campaign. He urged caution, but with infection rates decreasing, on Nov. 25, the Board of Health rescinded the city's mask order. Schools remained closed until Dec. 2.

"This measure enabled the board to bridge over a very alarming influenza situation and to reduce the chances of cross-infection," Morgan said in The Indianapolis News on Nov. 25.

Morgan, who led the Indianapolis Board of Health for 33 years until his death in 1946, added that the wearing of masks allowed the city to continue business and retain at least a semblance of normalcy.

"It prevented a large number of persons from being deprived of employment, a situation that would have developed if a closing ban on all forms of business had been established," he said. "While the mask recommendation was met with some opposition, the spirit of cooperation in the beginning was all that could have been expected and enabled the board to cut short the present epidemic."

Newspapers.com

By the time flu pandemic passed, Indianapolis had a rate of 290 deaths per 100,000 people, one of the lowest among U.S. cities, according to the "Influenza Encyclopedia," produced by the University of Michigan Center for the History of Medicine and Michigan Publishing.

Bill Beck, of the Marion County Historical Society, said he and Dr. William McNiece, the Historical Society's president, estimate 950 people in Indianapolis died from the flu in October, November and December 1918.

I get the impression that both the state board of health and the county board of public health were very proactive," Beck said.

Being proactive will be a necessity in the days, weeks and months ahead in the current battle against COVID-19, which has killed at least 132,000 Americans, including more than 2,500 Hoosiers.

"This pandemic has not gone away," current Indianapolis Mayor Joe Hogsett said last week while announcing a face mask mandate. "And across the country, we are seeing examples of what can happen when a city lets its guard down."

If there is a singular lesson we can apply from Morgan's campaign against the influenza pandemic of 1918 to the coronavirus pandemic of 2020, it is that the path toward defeating a virus leads only through cooperation and collective will.

This virus obeys the laws of physics. It obeys the laws of chemistry. It obeys the laws of biology," Beck said. "It couldn't care less about anything else. You have to just keep your focus on the virus. You don't focus on anything else, you focus on the virus.

The Indiana Medical History Museum will host a virtual presentation featuring Bill Beck and Dr. William McNiese titled "The 1918 Pandemic: Indianapolis Confronts the 1918 Spanish Influenza" at 2 p.m. Sunday, July 12.

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Genetic Engineering – an overview | ScienceDirect Topics

Posted: July 9, 2020 at 2:52 am

2.08.1 Introduction to Genetic Engineering

With the discovery of DNA as the universal genetic material in 1944 [1] and the elucidation of its molecular structure approximately a decade later [2], the era of DNA science and technology had officially begun. However, it wasnt until the 1970s that researchers began manipulating DNA with the use of highly specific enzymes, such as restriction endonucleases and DNA ligases. The experiments in molecular biology conducted within Stanford University and the surrounding Bay Area in 1972 represent the earliest examples of recombinant DNA technology and genetic engineering [3, 4]. Specifically, a team of molecular biologists were able to artificially construct a bacterial plasmid DNA molecule by splicing and combining fragments from two naturally occurring plasmids of distinct origin. The resulting recombinant DNA was then introduced into a bacterial Escherichia coli host strain for replication and expression of the resident genes. This famous example represents the first use of recombinant DNA technology to generate a genetically modified organism.

In general, genetic engineering (Figure 1) refers to all the techniques used to artificially modify an organism in order to produce a desired substance (such as an enzyme or a metabolite) that is not naturally produced by the organism, or to enhance a preexisting cellular process. As a first step, the desired DNA segment or gene is isolated from a source organism by extracting and purifying the total cellular DNA. The DNA is then manipulated using numerous laboratory techniques and inserted into a genetic carrier molecule in order to be delivered to the host strain. The means of gene delivery is dependent upon the type of organism involved and can be classified into viral and nonviral methods. Transformation (nonviral, for bacteria and lower eukaryotes), transfection (viral and nonviral, for eukaryotes), transduction (viral, for bacteria), and conjugation (cell-to-cell, for bacteria) are all commonly used methods for gene delivery and DNA transfer. Because no method of gene delivery is capable of transforming every cell within a population, the ability to distinguish recombinant cells from nonrecombinants constitutes a crucial aspect of genetic engineering. This step frequently involves the use of observable phenotypic differences between recombinant and nonrecombinant cells. In rare instances where no selection of recombinants is available, laborious screening techniques are required to locate an extremely small subpopulation of recombinant cells within a substantially larger population of wild-type cells.

Figure 1. Basic genetic engineering process scheme including replication and expression of recombinant DNA according to the central dogma of molecular biology.

Although cells are composed of various biomolecules including carbohydrates, lipids, nucleic acids, and proteins, DNA is the primary manipulation target for genetic engineering. According to the central dogma of molecular biology, DNA serves as a template for replication and gene expression, and therefore harnesses the genetic instructions required for the functioning of all living organisms. Through gene expression, coding segments of DNA are transcribed to form messenger RNAs, which are subsequently translated to form polypeptides or protein chains. Therefore, by manipulating DNA, we can potentially modify the structure, function, or activity of proteins and enzymes, which are the final products of gene expression. This concept forms the basis of many genetic engineering techniques such as recombinant protein production and protein engineering. Furthermore, virtually every cellular process is carried out and regulated by enzymes, including the reactions, pathways, and networks that constitute an organisms metabolism. Therefore, a cells metabolism can be deliberately altered modifying or even restructuring native metabolic pathways to lead to novel metabolic activities and capabilities, an application known as metabolic engineering. Such metabolic engineering approaches are often realized through DNA manipulation.

The first genetically engineered product approved by the US Food and Drug Administration (FDA) for commercial manufacturing appeared in 1982 when a strain of E. coli was engineered to produce recombinant human insulin [5]. Prior to this milestone, insulin was obtained predominantly from slaughterhouse animals, typically porcine and bovine, or by extraction from human cadavers. Insulin has a relatively simple structure composed of two small polypeptide chains joined through two intermolecular disulfide bonds. Unfortunately, wild-type E. coli is incapable of performing many posttranslational protein modifications, including the disulfide linkages required to form active insulin. In order to overcome this limitation, early forms of synthetic insulin were manufactured by first producing the recombinant polypeptide chains in different strains of bacteria and linking them through a chemical oxidation reaction [5]. However, nearly all current forms of insulin are produced using yeast rather than bacteria due to the yeasts ability to secrete a nearly perfect replica of human insulin without requiring any chemical modifications. Following the success of recombinant human insulin, recombinant forms of other biopharmaceuticals began appearing on the market, such as human growth hormone in 1985 [6] and tissue plasminogen activator in 1987 [7], all of which are produced using the same genetic engineering concepts as applied to the production of recombinant insulin.

As a result of the sheer number of applications and immense potential associated with genetic engineering, exercising bioethics becomes necessary. Concerns pertaining to the unethical and unsafe use of genetic engineering quickly arose with the advent of gene cloning and recombinant DNA technology in the 1970s, predominantly owing to a general lack of understanding and experience regarding the new technology. The ability of scientists to interfere with nature and alter the genetic makeup of living organisms was the focal point of many concerns surrounding genetic engineering. Although it is widely assumed that the potential agricultural, medical, and industrial benefits afforded by genetic engineering greatly outweigh the inherent risks surrounding such a powerful technology, most of the moral and ethical concerns raised during the inception of genetic engineering are still actively expressed today. For this reason, all genetically modified products produced worldwide are subject to government inspection and approval prior to their commercialization. Regardless of the application in question, a great deal of responsibility and care must be exercised when working with genetically engineered organisms to ensure the safe handling, treatment, and disposal of all genetically modified products and organisms.

As the field of biotechnology relies heavily upon the application of genetic engineering, this article introduces both the fundamental and applied concepts with regard to current genetic engineering methods and techniques. Particular emphasis shall be placed upon the genetic modification of bacterial systems, especially those involving the most famous workhorse E. coli on account of its well-known genetics, rapid growth, and ease of manipulation.

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Genetic Engineering: Pros & Cons – E&C

Posted: July 9, 2020 at 2:51 am

I think the ethics and morals of genetic engineering are very complicated. It intrigues me.

Roger Spottiswoode

Genetic engineering can be defined as manipulation of an organisms genes with the help of biotechnology.

The first official genetic manipulation happened in 1972 by Paul Berg when he combined the DNA from a monkey virus with the lambda virus.

Genetic engineering is a very controversial topic in our society. There are many pros and cons regarding this topic.

In the following, the advantages as wells as the downsides of genetic manipulation are examined.

In order to create a genetically modified organism, scientists first have to choose what gene they want to insert into the organism. With the help of genetic screens, potential genes can be tested with the goal of finding the best candidates.

When a suitable gene has been determined, the next step is to isolate it. The cell which contains the gene has to be opened and the DNA has to be purified.

After isolating the gene, it is ligated into a plasmid which is inserted into a bacterium. Thus, whenever the bacterium divides, the plasmid is also replicated. This leads to a vast number of copies of this gene.

Before inserting the gene into the target organism, it has to be combined with other genetic elements including a terminator and promoter region which end and initiate the transcription.

In the final step, the genetic material is inserted into a host genome. After that, the genetic engineering process is finished.

Genetic engineering is often used by scientists to improve their understanding on how genetics actually work and how they affect our talents and our decisions.

From these findings, scientists can provide insights for medical purposes and thus increase the probability for curing serious diseases in the future.

There are many important areas in the field of medicine in which genetic manipulation could contribute to a better treatment of diseases. This also includes the invention of more effective drugs with less side effects.

Moreover, model animals can be genetically modified in hope to get new insights on how these modifications would work on humans.

For this purpose, using mice in order to examine the effects of genetic manipulation on obesity, cancer, heart diseases and other serious conditions is common practice in nowadays scientific work.

Genetic engineering is also used in the field of agriculture in order to increase yields and also make plants more resistant to pests. Moreover, even genetic experiments on livestock have been performed in the past.

Apart from the use for consumption, plants have also been genetically modified for medical purposes. By changing the gene structure of plants, scientists want to examine if they could produce new drugs which can cure diseases more effectively.

Genetic manipulation is also a field of interest for industrial purposes. Since through genetic engineering processes, all kinds of properties of animals and plants can be modified, this also comes down to a potential increase in revenue for firms if they are able to optimize the gene structure for their purposes. An example for this is the use of genetically modified bacteria for making biofuels.

The rules for genetic engineering vary significantly across different countries. However, there is some consensus on the level of danger genetic modification poses to humanity.

For example, the majority of scientists claim that there is no greater risk to human health from genetically modified crops compared to conventional food.

However, before making this genetically modified food available for public consumption, it has to be tested extensively in order to exclude any possibility of danger.

Moreover, some groups like Greenpeace or the World Wildlife Fund claim that genetically modified food should be tested more rigorously before releasing it for public consumption.

There are some severe diseases which we will likely never be able to fight if we do not use genetic engineering. From only small manipulations of genes, it is expected that we can fight a significant number of deadly diseases. Moreover, even for unborn babies, there could be genetic diseases detected.

The most prominent example for this kind of genetic disease is the Down syndrome. If our scientists get quite advanced, it is likely that we would be able to cure all genetic diseases, even that of unborn children.

Abortions because of the diagnosis of genetic diseases would no longer be necessary since we could ensure the babies health through genetic manipulation.

Since we can fight many diseases with genetic engineering, the overall life expectancy of people is likely to increase since the dangers of death due to these diseases decreases. Moreover, if we are able to further improve our knowledge regarding genetic modification, diseases could be treated more effectively.

Especially in poor countries where some diseases can cause the death of many people, also the development of genetically modified plants for medical use could be a great measure in order to mitigate the issue. We could also fight diseases which usually cause death for old people and thus prolong their lifes.

Moreover, we can increase their life quality since old people do not have to suffer from these diseases anymore. Thus, genetic engineering may lead to an increase in average life expectancy.

With the help of genetic manipulation, we could increase the variety of foods and drinks for our daily consumption. Moreover, we could further improve the crop yields since we could create sorts of plants that are resistant to all kinds of pests. Thus, we could supply enough food to all people worldwide and fight famine in an effective way.

Additionally, with the help of genetic engineering, it may be possible to create more nutritious food. This would be especially beneficial in countries where people suffer from vitamin deficiencies. If we are able to increase the level of this vitamins in crops or other foods, we could help people to overcome their vitamin deficiency.

If we are able to modify the genetics in a way that they naturally become resistant against pests, we will no longer have to use harmful chemical pesticides. Thus, genetic engineering may also lead to a reduction in the use of pesticides.

With the help of genetic engineering, we may also be able to create certain medical foods which may also replace some of the common injections. Medical foods may also help to prevent certain diseases. Therefore, genetic engineering could also lead to an improvement of medical standards.

Through genetic engineering, it would be possible to create plant species which need less water than the plant species currently used in agriculture.

By replacing the natural species with genetically modified ones, farmers could save plenty of water. This would be especially useful in regions where water shortage is a serious problem.

Water shortage will be a quite big issue in the future due to global warming. If the average temperature increases, water scarcity is likely to also increase.

Thus, with the help of genetic modification, water can be saved and the problem of water shortages may be mitigated to a certain extent.

We may also be able to increase the speed of growth of plants and animals. By doing so, we could produce more food in a given period of time. This may quite important since our world population is growing and therefore the demand for food is increasing.

Through genetic modification, we may also be able to strengthen specific characteristics of plants. This may include that plants are better able to adapt to the global warming problem or that they may become more resistant to changes in their natural conditions.

Many followers of religions are strictly against genetic engineering since they think playing god should not be a task performed by humans. There are also ethic concerns if genetic manipulation should become a valid instrument for changing the course of our lifes.

There is also the argument that diseases are a natural phenomenon and that they have a role in nature since they persisted over a quite long time horizon of evolution. Moreover, there are many scientists who believe that the creation of designer babies could not be in the interest of humanity.

If perfected, parents could choose the eye color, hair color or even the sex of the baby. This could lead to an optimization contest in our society which could also have vast negative effects if pushed too far.

Genetic manipulation can also cause genetic problems if we do not handle it in a proper way. Since science is still on an early stage on the understanding of genetics, manipulations of genes may even do more harm than good at our current state of genetic understanding. Errors could even lead to the development of new diseases or to miscarriages.

Genetic engineering also poses a risk to human health. For example, genetically modified food may lead to long-term health issues. There is just not enough reliable data yet on how harmful genetic engineering really is in the long term. Thus, it may pose serious health effects, some of them currently even unknown by scientists.

Genetic engineering may also lead to the development of allergies against certain food items. Since the DNA-structure is altered in the genetic modification process, food that has former been uncritical for people could now cause allergic reactions.

Genetic engineering is also used to modify plants. Specifically, some plant species have been developed which include their own pesticide which can protect them from animals and insects.

In this way, scientists hope to be able to increase crop yields. However, this altering of genetic code in plants can lead to a resistance of certain insects to the pesticide.

This may pose big problems to the agricultural system since if insects or other pests become resistant against toxins, they are harder to fight.

Thus, in the short run, altering genetic material in plants may have its advantages. However, in the long run, there may be severe issues when it comes to resistance of pest strains.

Some researchers are afraid that genetic engineering may also lead to a resistance against antibiotics for humans. This may lead to serious problems since the treatment of diseases with antibiotics will not be effective anymore.

Genetic engineering would also lead to a reduction in genetic diversity. Since the process of gene manipulation would be quite expensive, only rich people would be able to afford it.

Thus, this would likely lead to human behavior which favors being rich over all other things in order to be able to afford genetic manipulation. As a consequence, the variety of human behavior would be reduced.

Since genetically modified plants often contain own pesticides, they can be quite harmful to animals which are consuming these kinds of plants. Animals can suffer severe diseases from these pesticides and even die.

This problem is especially severe for butterflies and other insects which usually rely on certain plants in their near surroundings. If the natural versions of plants are replaced by genetically modified plants containing pesticides, these insects are likely to suffer from severe health conditions.

Researchers found that residues of genetically modified plants persist on the soil of fields for many months. Thus, the activity of microbes is adversely affected which can lead to a loss in fertility of the soil.

If genetically modified plants are more resistant against pests, chances are that they will displace local natural plant species in the long run. This also contributes to a reduction in genetic variety and can cause the issues related to this phenomenon.

Genetic engineering is an area which can be quite profitable for some firms. However, it is also quite expensive field of study. There are some big companies which have huge control over the seed market and thus also have a big influence on political decisions regarding the admission of genetically engineered plants for agricultural purposes.

Thus, even if there may be dangers from these admissions, companies may still get permission to sell the genetically modified seeds since they may have high influence on political decision makers.

Golden rice, unlike any other sort of rice, also contains provitamin A. It is estimated that a lack of this vitamin causes up to 500.000 cases of blindness across children each year.

Moreover, around one million people even die from a lack of this vitamin. Thus, the introduction of this gene manipulated golden rice could mitigate this problem.

Genes from the mouse-ear cress are studied extensively since they help scientists to understand the nature of a variety of plant characteristics concerning photosynthetic activity, droughts, growth speed and many more.

After finding the genes related to different characteristics of the mouse-ear cress, they can be used to modify the genes of cultivated species in order to improve their yields and resistance.

Even just a small modification in the genes of onions have led to significant effects. On the one hand, the modified onion doesnt make people cry anymore when they cut it. On the other hand, the concentration of healthy compounds like sulphur-containing substances has been increased.

There has been attempts to lower the concentration of saturated fatty acids in soy oil. Moreover, there are also companies trying to increase the level of omega-3 fatty acids of their oils.

In order to fight the osteoporosis problem, genetically modified carrots with a higher concentration of organically bound calcium have been produced. Studies have shown that humans were able to absorb 42% more calcium from the modified carrots than from normal carrots.

There have been several experiments of genetic modification in order to fight abiotic stress with the purpose of increasing frost resistance, drought resistance or the resistance against flooded fields.

Bananas are an important source of calories for many people. However, they are vulnerable to new kinds of diseases. Thus, a pepper gene has been inserted in bananas in order to make them more resistant.

Transferring a gene from a decorative plant into a tomato not only changed the color of the tomato from red to purple, it also enabled the tomato to produce anthocyanin, which prevented mice from getting cancer.

When cutting an apple and leaving it untouched for a while, it usually turns brown. There have been attempts from industries to create a sort of apples called Artic apple, which will no longer turn brown after cutting.

Genetic engineering is a quite controversial topic in our society. It has many advantages and fields of application, but can also have detrimental effects on humans as well as on the whole ecological system.

There are also many religious and ethic concerns against the use of gene manipulation. Thus, as humans, we have to make difficult decisions in the future on whether we want to play god in order to be able to fight deadly diseases or if we do not want to take the risk.

Sources

http://www.fao.org/3/Y5160E/y5160e10.htm#P3_1651The

http://www.fao.org/3/y4955e/y4955e06.htm

https://en.wikipedia.org/wiki/Genetic_engineering

About the author

My name is Andreas and my mission is to educate people of all ages about our environmental problems and how everyone can make a contribution to mitigate these issues.

As I went to university and got my Masters degree in Economics, I did plenty of research in the field of Development Economics.

After finishing university, I traveled around the world. From this time on, I wanted to make a contribution to ensure a livable future for the next generations in every part of our beautiful planet.

Wanna make a contribution to save our environment? Share it!

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Genetic Engineering: Pros & Cons - E&C

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Joy Adzovie: Genetically Modified Crops is the solution to global food insecurity – Myjoyonline.com

Posted: July 9, 2020 at 2:51 am

Genetically Modified Crops (GM crops) have generated a lot of controversies over the years. They have sparked debates among farmers and consumers alike with people always particularly paying attention to labeled GM and non-GM commodities on the market.

Some describe is as genetic modification. Some call it genetic engineering. Some call them genetically modified organisms (GMOs). Others describe them as biotechnology products, although biotechnology is a broader term. But all of them refer to the same thing.

A lot of ethical concerns have arisen about GM technology over the years. A very common claim made by some anti-GM activists is that you cannot play God which implies that scientists are defying the natural order of creation. Others are concerned about possible health risks associated with the consumption of GM foods although they have been proven scientifically to be safe, 20 years after their introduction.

In fact, in countries like USA, Brazil and South Africa, more than 80% of all soya beans, maize and cotton are GM crops. But there has been no single evidence of any of these crops negatively impacting the health of consumers in those countries. Before GM food is released for consumption, it is subjected to rigorous scrutiny which has zero tolerance for errors.

So, what exactly are GM crops?

In a bid to optimize yield, farmers have been breeding suitable varieties of crops through conventional selection for several centuries. This has made most wild ancestors of crops such as teosinte of maize go into extinction leaving the elite cultivars which look bigger and develop more desirable traits over the generations. This method of breeding is known as selective breeding or artificial selection which is globally accepted but currently inefficient to feed a fast-growing population anticipated to reach 9.6 billion in the next couple of decades. The exponential rise in population is inversely related to available land area hence the need for a more strategic approach to efficiently utilize the limited land resource to feed the growing global population. Also, pests and diseases, climate change, amidst other abiotic factors severely constrain crop production.

Biotechnology (which includes genetic modification) is an applied science that harnesses the natural biological capabilities of microbial, plants and animal cells for the benefit of mankind. It has changed the quality of life through improved medicine, diagnostics, agriculture and waste management, as well as offered opportunities for innovation and discoveries.

Genetic engineering is used to efficiently and precisely modify targeted plants using advanced biotechnological techniques. Advances in molecular biology have helped eliminate certain gaps in breeding such as reducing time to successfully introduce (introgress) a gene of interest into a commercial crop variety through a process called speed breeding and eradicating linkage drags associated with conventional breeding.

The principle is a simple one. To genetically improve or enhance a crop such as sweet potato which is susceptible to nematode attack, another crop such as tomato that is resistant to nematode attack is identified and the gene of interest is isolated. The gene isolated from the tomato is then introduced into the sweet potato. The host plant becomes a transgenic or genetically modified plant which expresses the desired trait (resistance to nematode) in subsequent generations.

Genetic engineering has had several uses such as in biofortification of crops to increase the concentration and availability of nutrients in crops hence solving hidden hunger problem faced by several African countries. The technology has also been used in the enhancement of plant architecture to optimize land usage and increase yield per area of land cultivated; and improved crops with heightened tolerance or resistance to both biotic and abiotic stresses including diseases and weather.

Benefits of GM crops

Some analysis shows that between 1996 and 2015,GM technology increased global production of corn by 357.7 million tons, soybean by 180.3 million tons, cotton fiber by 25.2 million, and canola by 10.6 million tons. GM crops also significantly reduced the use of agricultural land due to this higher productivity. In 2015 alone, they prevented almost 20 million hectares from being used for agricultural purposes, thus reducing the environmental impact of cultivating forests or wild lands. This is a great environmental benefit derived from higher agricultural yield.

Unfortunately, in Africa, only a few countries including South Africa and South Sudan have allowed for the growing of GM crops and are enjoying from these benefits. Ghana has not allowed for the local production of GM crops although parliament passed a law in 2011 to allow for their introduction.

Genetic engineering is a viable way to eradicate hunger and ensure food security in the coming decades hence is pivotal to achieving Sustainable Development Goal (SDG) 2 on eliminating hunger. Yield losses due to changing or fluctuating climate, pests, and diseases, drought, acidic or saline soils and, heat stress can all be remedied by growing genetically modified crops. GM technology is a blessing to mankind and promises a hunger-free future especially in such unsettling times with the COVID-19 pandemic. Lets embrace it.

The author is a Teaching Assistant at the University of Ghana, Graduate, Faculty of Agriculture.

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