Prof. Brian Catchpole – Our People – About – Royal …

Brians research interests centre around canine immunology and immunogenetics in relation to susceptibility to immune-mediated diseases and response to vaccination. Brian is currentlyinvestigating canine endocrine disease, more specifically working to understand the pathogenesis of diabetes mellitus, hypothyroidism and hypoadrenocorticism in dogs.

Brianis also involved in a studycharacterising canine innate immune response genes to determine whether these are involved in susceptibility to various disease syndromes (including anal furunculosis and inflammatory bowel disease). Alongside this, Brian is also examining the genetics of vaccine responses in dogs; how immune response genes can influence the response to vaccination and how immunosenescence impacts on the immune response as dogs get older.

Addisons disease (hypoadrenocorticism) is an autoimmune condition that occurs in dogs when the immune system attacks and destroys the adrenal gland, leading to a deficiency of steroid hormones.

We are interested in the genetics and autoimmune response in canine Addisons disease and have identified autoantibodies in the blood that react to proteins in the adrenal gland. We are interested in carrying out further research into this disease, to measure these autoantibodies, to see whether they can be used as part of diagnostic testing and potentially to identify dogs that have an autoimmune reaction, before they develop clinical signs. We are keen to recruit dogs that are undergoing blood sampling as part of diagnostic testing for Addisons disease or who are being monitored for their response to steroid replacement therapy.

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1: Dutton LC, Dudhia J, Catchpole B, Hodgkiss-Geere H, Werling D, Connolly DJ.Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2acting via the EP4 receptor. Sci Rep. 2018 Sep 6;8(1):13351. doi:10.1038/s41598-018-31569-1. PubMed PMID: 30190508; PubMed Central PMCID:PMC6127326.

2: Boag AM, Christie MR, McLaughlin KA, Syme HM, Graham P, Catchpole B. Alongitudinal study of autoantibodies against cytochrome P450 side-chain cleavageenzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism(Addison's disease). Vet Immunol Immunopathol. 2018 Aug;202:41-45. doi:10.1016/j.vetimm.2018.05.013. Epub 2018 May 26. PubMed PMID: 30078597.

3: Soutter F, Martorell S, Solano-Gallego L, Catchpole B. Inconsistent MHC classII association in Beagles experimentally infected with Leishmania infantum. VetJ. 2018 May;235:9-15. doi: 10.1016/j.tvjl.2018.03.001. Epub 2018 Mar 7. PubMedPMID: 29704945.

4: Holder A, Jones G, Soutter F, Palmer DB, Aspinall R, Catchpole B.Polymorphisms in the canine IL7R 3'UTR are associated with thymic output inLabrador retriever dogs and influence post-transcriptional regulation by microRNA185. Dev Comp Immunol. 2018 Apr;81:244-251. doi: 10.1016/j.dci.2017.12.008. Epub2017 Dec 14. PubMed PMID: 29247721.

5: Holder A, Mirczuk SM, Fowkes RC, Palmer DB, Aspinall R, Catchpole B.Perturbation of the T cell receptor repertoire occurs with increasing age indogs. Dev Comp Immunol. 2018 Feb;79:150-157. doi: 10.1016/j.dci.2017.10.020. Epub2017 Oct 28. PubMed PMID: 29103899; PubMed Central PMCID: PMC5711257.

6: Dutton LC, Church SAV, Hodgkiss-Geere H, Catchpole B, Huggins A, Dudhia J,Connolly DJ. Cryopreservation of canine cardiosphere-derived cells: Implicationsfor clinical application. Cytometry A. 2018 Jan;93(1):115-124. doi:10.1002/cyto.a.23186. Epub 2017 Aug 22. PubMed PMID: 28834400.

7: O'Kell AL, Wasserfall C, Catchpole B, Davison LJ, Hess RS, Kushner JA,Atkinson MA. Comparative Pathogenesis of Autoimmune Diabetes in Humans, NOD Mice,and Canines: Has a Valuable Animal Model of Type 1 Diabetes Been Overlooked?Diabetes. 2017 Jun;66(6):1443-1452. doi: 10.2337/db16-1551. PubMed PMID:28533295; PubMed Central PMCID: PMC5440022.

8: Davison LJ, Holder A, Catchpole B, O'Callaghan CA. The Canine POMC Gene,Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus. J VetIntern Med. 2017 Mar;31(2):343-348. doi: 10.1111/jvim.14636. Epub 2017 Feb 8.Erratum in: J Vet Intern Med. 2017 Jul;31(4):1362. PubMed PMID: 28176381; PubMedCentral PMCID: PMC5354034.

9: Scudder CJ, Niessen SJ, Catchpole B, Fowkes RC, Church DB, Forcada Y. Felinehypersomatotropism and acromegaly tumorigenesis: a potential role for the AIPgene. Domest Anim Endocrinol. 2017 Apr;59:134-139. doi:10.1016/j.domaniend.2016.11.005. Epub 2016 Dec 8. PubMed PMID: 28119176.

10: Peiravan A, Allenspach K, Boag AM, Soutter F, Holder A, Catchpole B, KennedyLJ, Werling D, Procoli F. Single nucleotide polymorphisms in majorhistocompatibility class II haplotypes are associated with potential resistanceto inflammatory bowel disease in German shepherd dogs. Vet Immunol Immunopathol.2016 Dec;182:101-105. doi: 10.1016/j.vetimm.2016.10.012. Epub 2016 Oct 22. PubMedPMID: 27863539.

11: Holder A, Mella S, Palmer DB, Aspinall R, Catchpole B. An Age-AssociatedDecline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoSOne. 2016 Nov 8;11(11):e0165968. doi: 10.1371/journal.pone.0165968. eCollection2016. PubMed PMID: 27824893; PubMed Central PMCID: PMC5100965.

12: Boag AM, Christie MR, McLaughlin KA, Syme HM, Graham P, Catchpole B.Autoantibodies against Cytochrome P450 Side-Chain Cleavage Enzyme in Dogs (Canislupus familiaris) Affected with Hypoadrenocorticism (Addison's Disease). PLoSOne. 2015 Nov 30;10(11):e0143458. doi: 10.1371/journal.pone.0143458. eCollection2015. PubMed PMID: 26618927; PubMed Central PMCID: PMC4664467.

13: Threlfall AJ, Boag AM, Soutter F, Glanemann B, Syme HM, Catchpole B. Analysisof DLA-DQB1 and polymorphisms in CTLA4 in Cocker spaniels affected withimmune-mediated haemolytic anaemia. Canine Genet Epidemiol. 2015 Jun 9;2:8. doi:10.1186/s40575-015-0020-y. eCollection 2015. PubMed PMID: 26401336; PubMedCentral PMCID: PMC4579385.

14: Holder AL, Kennedy LJ, Ollier WE, Catchpole B. Breed differences indevelopment of anti-insulin antibodies in diabetic dogs and investigation of therole of dog leukocyte antigen (DLA) genes. Vet Immunol Immunopathol. 2015 Oct15;167(3-4):130-8. doi: 10.1016/j.vetimm.2015.07.014. Epub 2015 Aug 2. PubMedPMID: 26272177.

15: Boag AM, Catchpole B. A review of the genetics of hypoadrenocorticism. TopCompanion Anim Med. 2014 Dec;29(4):96-101. doi: 10.1053/j.tcam.2015.01.001. Epub2015 Jan 5. Review. PubMed PMID: 25813849.

16: Killick DR, Stell AJ, Catchpole B. Immunotherapy for canine cancer--is ittime to go back to the future? J Small Anim Pract. 2015 Apr;56(4):229-41. doi:10.1111/jsap.12336. Epub 2015 Feb 23. Review. PubMed PMID: 25704119.

17: Soutter F, Kennedy LJ, Ollier WE, Solano-Gallego L, Catchpole B. Restricteddog leucocyte antigen (DLA) class II haplotypes and genotypes in Beagles. Vet J.2015 Mar;203(3):345-7. doi: 10.1016/j.tvjl.2014.12.032. Epub 2015 Jan 5. PubMedPMID: 25634081; PubMed Central PMCID: PMC4366010.

18: Adams JP, Holder AL, Catchpole B. Recombinant canine single chain insulinanalogues: insulin receptor binding capacity and ability to stimulate glucoseuptake. Vet J. 2014 Dec;202(3):436-42. doi: 10.1016/j.tvjl.2014.09.027. Epub 2014Oct 5. PubMed PMID: 25457265.

19: Short AD, Catchpole B, Boag AM, Kennedy LJ, Massey J, Rothwell S, HenthornPS, Littman MP, Husebye E, Ollier B. Putative candidate genes for caninehypoadrenocorticism (Addison's disease) in multiple dog breeds. Vet Rec. 2014 Nov1;175(17):430. doi: 10.1136/vr.102160. Epub 2014 Aug 14. PubMed PMID: 25124887.

20: Kathrani A, Lee H, White C, Catchpole B, Murphy A, German A, Werling D,Allenspach K. Association between nucleotide oligomerisation domain two (Nod2)gene polymorphisms and canine inflammatory bowel disease. Vet ImmunolImmunopathol. 2014 Sep 15;161(1-2):32-41. doi: 10.1016/j.vetimm.2014.06.003. Epub2014 Jun 26. PubMed PMID: 25017709.

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Prof. Brian Catchpole - Our People - About - Royal ...