SENS5 – Cellular Therapy for Intestinal Regeneration – Video

Posted: February 21, 2013 at 5:42 am


Video Link: https://www.youtube.com/watch?v=xblxwrigEJI



SENS5 - Cellular Therapy for Intestinal Regeneration
SENS Foundation 2011 - http://www.sens.org The Fifth SENS conference - Graca Almeida-Porada Authors E. Colletti, J. Wood, DA Ingram, ED Zanjani, M. Yoder, C. Porada, G. Almeida-Porada Wake Forest Institute for Regenerative Medicine Abnormal or inadequate vasculogenesis, local inflammation, and severe epithelial damage are common features of both inflammatory bowel disease (IBD) and radiation-induced injury resulting from pelvic or abdominal cancer treatment. Several studies have shown that adult bone marrow-derived stem cells, such as mesenchymal stem cells (MSC), upon transplantation, home to the damaged digestive tissue and facilitate mucosal repair in both IBD and radiation injury. Nevertheless, the levels of MSC intestinal engraftment are low, underscoring the need for finding ways to improve engraftment of these cells. It has also been shown that endothelial progenitor cells (EPC) exist in decreased numbers in the peripheral blood of IBD patients, which is in contrast to the presently held convention that the presence of an inflammatory state promotes the mobilization of EPC into the circulation. Furthermore, intestinal microvascular and endothelial cell dysfunction can lead to persistent tissue hypoperfusion and ischemia, further contributing to chronic inflammation. Therefore, here we investigated whether transplanted EPC can contribute to the intestinal vasculogenic process and/or the stem or mature epithelial cell pool of the intestine, and whether it is possible to ...

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SENS5 - Cellular Therapy for Intestinal Regeneration - Video

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