Cartilage developed from stem cells for arthritis cure

London, Mar 4:

Scientists have successfully developed healthy cartilage from embryonic stem cells, a breakthrough that could help treat arthritis patients.

Researchers grew and transformed embryonic stem cells into cartilage cells also known as chondrocytes.

This work represents an important step forward in treating cartilage damage by using embryonic stem cells to form new tissue, although its still in its early experimental stages, said Professor Sue Kimber and her team in the Faculty of Life Sciences at The University of Manchester.

During the study, the team analysed the ability of embryonic stems cells to become precursor cartilage cells.

They were then implanted into cartilage defects in the knee joints of rats.

After four weeks cartilage was partially repaired and following 12 weeks a smooth surface, which appeared similar to normal cartilage, was observed.

Further study of this newly regenerated cartilage showed that cartilage cells from embryonic stem cells were still present and active within the tissue.

Developing and testing this protocol in rats is the first step in generating the information needed to run a study in people with arthritis.

Before this will be possible more data will need to be collected to check that this protocol is effective and that there are no toxic side-effects, researchers said.

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Cartilage developed from stem cells for arthritis cure