Deaf gerbils hear again with human stem cells

Human stem cell-derived otic neurons repopulating the cochlea of deaf gerbils are seen in this undated handout photo courtesy of the University of Sheffield.

Credit: Reuters/Marcelo Rivolta/University of Sheffield/Handout

By Ben Hirschler

LONDON | Wed Sep 12, 2012 1:09pm EDT

LONDON (Reuters) - Scientists have restored hearing to deaf gerbils using human embryonic stem cells in an advance that could eventually help people with an intractable form of deafness caused by nerve damage.

The procedure needs further animal research to assess safety and long-term effectiveness but researchers said on Wednesday the experiment was an important proof of concept, marking a further advance in the growing field of regenerative medicine.

Marcelo Rivolta from Britain's University of Sheffield, who led the research, said the first patients could receive cell therapy for hearing loss in clinical trials in "a few years".

After treating 18 gerbils with complete deafness in one ear, his team reported in the journal Nature that stem cells produced an average 46 percent recovery in hearing function, as measured by electrical signals in the animals' brains.

"If this was a human patient, it would mean going from being so deaf as to be unable to hear a lorry or truck on the street to being able to maintain a conversation," Rivolta told reporters.

"What we have shown here is functional recovery using human stem cells, which is unique."

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Deaf gerbils hear again with human stem cells