Investigators from Chongqing University Target Stem Cells

By a News Reporter-Staff News Editor at Stem Cell Week -- A new study on Stem Cell Research is now available. According to news reporting from Chongqing, People's Republic of China, by NewsRx journalists, research stated, "The purpose of this study was to investigate the influences of nanoscale wear particles derived from titanium/titanium alloy-based implants on integration of bone. Here we report the potential impact of titanium oxide (TiO2) nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells (MSC) from the cellular level to the molecular level in the Wistar rat."

The news correspondents obtained a quote from the research from Chongqing University, "A series of TiO2 nanoparticles (14 nm, 108 nm, and 196 nm) were synthesized and characterized by scanning electron microscopy and transmission electron microscopy, respectively. The TiO2 nanoparticles had negative effects on cell viability, proliferation, and the cell cycle of MSC in a dose-dependent and size-dependent manner. Confocal laser scanning microscopy was used to investigate the effects of particle internalization on adhesion, spreading, and morphology of MSC. The integrity of the cell membrane, cytoskeleton, and vinculin of MSC were negatively influenced by large TiO2 nanoparticles. The Transwell migration assay and a wound healing model suggested that TiO2 nanoparticles had a strong adverse impact on cell migration as particle size increased (P < 0.01)."

According to the news reporters, the research concluded: "Furthermore, alkaline phosphatase, gene expression of osteocalcin (OC) and osteopontin (OPN), and mineralization measurements indicate that the size of the TiO2 nanoparticles negatively affected osteogenic differentiation of MSC."

For more information on this research see: Effects of titanium nanoparticles on adhesion, migration, proliferation, and differentiation of mesenchymal stem cells. International Journal of Nanomedicine, 2013;8():3619-3630. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Stem Cell Research).

Our news journalists report that additional information may be obtained by contacting Y.H. Hou, Chongqing Univ, Coll Bioengn, Minist Educ, Chongqing 400044, People's Republic of China. Additional authors for this research include K.Y. Cai, J.H. Li, X.Y. Chen, M. Lai, Y. Hu, Z. Luo, X.W. Ding and D.W. Xu.

Keywords for this news article include: Asia, Titanium, Chongqing, Light Metals, Stem Cell Research, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

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Investigators from Chongqing University Target Stem Cells