New method makes stem cells in about 30 minutes …

In a feat that experts say is a significant advance for regenerative medicine, scientists have discovered a surprisingly simple method for creating personalized stem cells that doesnt involve human embryos or tinkering with DNA.

Two studies published Wednesday in the journal Nature describe a novel procedure for reprogramming the blood cells of newborn mice by soaking the cells in a mildly acidic solution for 30 minutes. This near-fatal shock caused the cells to become pluripotent, or capable of growing into any type of cell in the body.

When the reprogrammed cells were tagged and injected into a developing mouse, they multiplied and grew into heart, bone, brain and other organs, the scientists found.

It was really surprising to see that such a remarkable transformation could be triggered simply by stimuli from outside of the cell, said lead study author Haruko Obokata, a biochemistry researcher at the RIKEN research institute in Japan. Very surprising.

The simplicity of the technique, which Obokata and her colleagues dubbed stimulus triggered acquisition of pluripotency, or STAP, caught many experts off-guard.

So you mistreat cells under the right conditions and they assume a different state of differentiation? Its remarkable, said Rudolf Jaenisch, a pioneering stem cell researcher at MIT who was not involved in the study. Lets see whether it works in human cells, and theres no reason why it shouldnt.

Obokata said that researchers had already begun experiments on human cells, but offered no details.

VIDEO: A beating heart, grown from STAP stem cells

Due to their Zelig-like ability to form any number of specialized cells, pluripotent stem cells are considered the basic building blocks of biology. Scientists are working on ways to use them to repair severed spinal cords, replace diseased organs, and treat conditions as varied as diabetes, blindness and muscular dystrophy.

By using stem cells spawned from the patients own cells, replacement tissues would stand less of a chance of being attacked by the patients own immune system, researchers say. That would spare patients the need to undergo a lifetime regimen of dangerous, immune-suppressing drugs.

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New method makes stem cells in about 30 minutes ...