Scientists grow miniature human stomachs from stem cells

A CT scan of a human abdomen with stomach cancer. Photograph: Bojan Fatur/Getty Images

Scientists have grown miniature human stomachs from stem cells as a way of studying gastric diseases such as ulcers and stomach cancer and in the future creating tissue to repair patients stomachs.

The mini-stomachs are grown in petri dishes from stem cells. Fully formed, they are the size of a pea and shaped like a rugby ball. They are hollow with an interior lining that is folded into glands and pits like a real stomach.

Crucially, the researchers found that the miniature stomachs, known as gastric organoids, respond to infection very much like ordinary human stomachs.

There hasnt been any good way to study human stomach disease before because animals just dont get the same diseases, said James Wells, director of the Pluripotent Stem Cell Facility, Cincinnati Childrens Hospital Medical Center, who led the research which is published in Nature.

Human gastric diseases are associated with chronic infection by the bacterium Helicobacter pylori. Half the worlds population is infected with the bug, which can be picked up from food. Although most people do not show symptoms, once the infection is present up to 20% of carriers will develop gastric ulcers during their lifetimes. Around 2% will develop stomach cancer.

In developing countries, where H. pylori infection is more prevalent, gastric cancers are the second leading cause of cancer-related deaths.

Having grown the mini-stomachs, the researchers then injected them with H. pylori. In animals, H. pylori has little effect and disease does not follow but in the gastric organoid, the invading bacteria behaved as if it were a real human stomach.

The bacteria began injecting their proteins into the surrounding cells, and started to multiply. This is the hallmark of infection, said Wells. We can now very effectively study the bacteria and how it generates diseases. This has never been possible before with human tissue in vitro.

This is not the first time that miniature organs have been grown from stem cells. In 2013, scientists grew miniature kidneys and successfully transplanted into a rat. Replacement windpipes, grown from stem cells on lab-made scaffolds, have also been grown and transplanted into patients.

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Scientists grow miniature human stomachs from stem cells